Glucose Patents (Class 436/95)
-
Publication number: 20090208989Abstract: The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement.Type: ApplicationFiled: February 9, 2009Publication date: August 20, 2009Applicant: ROCHE DIAGNOSTICS OPERATIONS INC.Inventors: Wolfgang Petrich, Claudia Gaessler-Dietsche, Carina Horn, Kai Hebestreit, Jean-Michel Asfour, Klemens Bardelang, Gerrit Kocherscheidt
-
Publication number: 20090191642Abstract: A polymeric sensing fluid for detecting the presence of glucose and systems and methods of its use are generally disclosed. The polymeric sensing fluid includes a polymer in a solvent (e.g., an aqueous solvent). The polymer has a plurality of boronic acid moieties extending from its polymeric backbone. As such, the polymeric sensing fluid is configured to increase in viscosity upon addition of glucose due to crosslinking between the boronic acid moieties of the polymer and glucose.Type: ApplicationFiled: January 29, 2009Publication date: July 30, 2009Applicant: UNIVERSITY OF SOUTH CAROLINAInventors: Qian Wang, Siqi Li
-
Patent number: 7565249Abstract: A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (5), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The method comprises providing a plurality of detection measurements, in which light is irradiated as primary light into the biological matrix and measuring an intensity value of secondary light emerging at a plurality detection sites, located in different measuring distances from the irradiation site. In an evaluation step, the light transport parameter is derived, by means of an evaluation algorithm, from the measured intensity values.Type: GrantFiled: February 23, 2002Date of Patent: July 21, 2009Assignee: Roche Diagnostics Operations, Inc.Inventors: Uwe Kraemer, Heinz-Michael Hein, Dietmar Volz
-
Patent number: 7556934Abstract: A sensor and method for measuring the concentration of one or more chemical substances within a solution. The sensor including a body of saturated hydrogel held within a sensor body. A window to allow flow through of the chemical substance to be measured. The hydrogel is held under a predetermined compressive force within the sensor body such that the hydrogel exerts a base pressure. A pressure sensor such as a strain gauge senses the pressure exerted by the hydrogel within the sensor body. The sensed pressure is stored or displayed. The hydrogel is reactive to the one or more chemical substances so that contact causes the hydrogel to either increase the pressure above the base pressure under which the hydrogel is held or to decrease the pressure relative to the base pressure of the hydrogel.Type: GrantFiled: October 4, 2002Date of Patent: July 7, 2009Inventor: Clive Lindsay Ragless
-
Patent number: 7521244Abstract: Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated hemoglobin as well as other analytes of interest in animal tissue samples. The reference solutions of the disclosure utilize a synthetic cruor in combination with an Hb peptide chain.Type: GrantFiled: October 26, 2006Date of Patent: April 21, 2009Assignee: Bionostics, Inc.Inventors: Minna A. Rannikko, Donna Connors, Donna Rafferty
-
Publication number: 20090087913Abstract: A method, system, kit and uses for quantifying and normalizing at least one product of ethanol metabolism are provided. A method is provided for quantifying and normalizing at least one product of ethanol metabolism in a sample comprising creatinine. The method comprises adding a predetermined amount of at least one internal standard to the sample; adding deuterated creatinine to the sample; detecting and measuring at least one product of ethanol metabolism, the predetermined amount of at least one internal standard in the sample, the deuterated creatinine, and the creatinine. The method also comprises quantifying the amount of at least one product of ethanol metabolism in the sample using the measurement of the at least one internal standard; quantifying the amount of creatinine in the sample using the measurement of the deuterated creatinine; and normalizing the quantity of the at least one product of metabolism using the measurement of the creatinine.Type: ApplicationFiled: September 29, 2008Publication date: April 2, 2009Applicants: MDS Analytical Technologies, a business unit of MDS Inc.,doing business through its Sciex Division, Applied Biosystems Inc.Inventor: Takeo Sakuma
-
Publication number: 20090081803Abstract: The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.Type: ApplicationFiled: July 11, 2008Publication date: March 26, 2009Applicant: Glumetrics Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
-
Publication number: 20090075389Abstract: A reagent strip for measuring the concentration of glucose in whole blood has a polymer on at least one side thereof to increase the opacity thereof, thereby reducing the effect of hematocrit on the glucose determination.Type: ApplicationFiled: October 6, 2008Publication date: March 19, 2009Inventor: Karen L. Marfurt
-
Publication number: 20090061418Abstract: The present invention generally relates to the determination of an analyte concentration (quantitative determination) or whether an analyte threshold level has been passed (qualitative determination) in a biological sample through employment of a disposable analytical microprocessor device. The device can include a batch-specific, self-executable algorithm for the calculation of the analyte concentration.Type: ApplicationFiled: August 29, 2008Publication date: March 5, 2009Applicant: LIFEASSAYS ABInventors: Dario KRIZ, Kristin Kriz
-
Publication number: 20090061528Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: ApplicationFiled: August 6, 2008Publication date: March 5, 2009Applicant: GLUMETRICS INC.Inventor: JEFF T. SURI
-
Publication number: 20090053815Abstract: A method of measuring the amount of an analyte in a sample, comprises (a) passing the sample through a flow channel in or on a holographic sensor, wherein the analyte interacts with and is retained by the sensor and wherein the interaction of the analyte changes an optical property of the sensor, and (b) monitoring analyte interaction, wherein the distance along the flow channel at which analyte interaction occurs or the area of the channel over which analyte interaction occurs, indicates the amount of analyte in the sample. Further, a method of detecting an analyte in a sample, comprises (a) passing the sample through a flow channel in or on a holographic sensor, wherein the analyte interacts with the sensor, thereby changing an optical property of the sensor, and wherein the flow channel defines a symbol; and (b) detecting the analyte by observing the appearance, disappearance or change in appearance of the symbol.Type: ApplicationFiled: September 29, 2006Publication date: February 26, 2009Inventors: Alexander James Marshall, Simon Kew
-
Patent number: 7494816Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.Type: GrantFiled: October 17, 2003Date of Patent: February 24, 2009Assignees: Roche Diagnostic Operations, Inc., Roche Operations Ltd.Inventors: David W. Burke, Lance S. Kuhn, Terry A. Beaty, Vladimir Svetnik
-
Patent number: 7494818Abstract: A multilayer test strip that measures concentrations of multiple analytes from a single whole blood sample. The test strip includes a test matrix of several layers held together in constant contact by a test strip holder. The invention is characterized in that it has no moving parts, which is made possible by the novel use of an elongate disbursement layer that spreads blood throughout its entire length, despite having layers with known wicking properties adjacent to and in contact with it. Since the invention relies primarily on a vertical flow format, the test strip is advantageously quite compact. With a single 30-50 microliter sample of blood applied thereto, the novel test strip can provide readings of total cholesterol, HDL cholesterol and triglycerides. From these, LDL can be calculated, thereby providing a full “lipid panel.” Other analytes such as glucose and ketones may be included in the test strip in addition to or in lieu of one or more of the other analytes.Type: GrantFiled: December 30, 2002Date of Patent: February 24, 2009Assignee: Polymer Technology Systems, Inc.Inventors: Sunil G. Anaokar, Michele Jeanne Crispino, Emanuel Paul Crabtree
-
Patent number: 7488601Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.Type: GrantFiled: October 17, 2003Date of Patent: February 10, 2009Assignees: Roche Diagnostic Operations, Inc., Roche Operations Ltd.Inventors: David W. Burke, Lance S. Kuhn, James Maxwell
-
Publication number: 20090036764Abstract: Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.Type: ApplicationFiled: May 19, 2008Publication date: February 5, 2009Applicant: OptiScan Biomedical CorporationInventors: Gil Rivas, Michael Butler, Jeffrey T. Chiou, Eugene Lim
-
Patent number: 7485854Abstract: A sampling device, for example a sampling valve, is disclosed for introduction of samples into an analysis system. The sampling device comprises a turning element provided with a sampling area. The sampling area is configured to retain samples to be analysed. The turning element is arranged for movement between a first position where the sampling area is exposed to material to be sampled for collection of samples and a second position where samples are released for use by the analysis system.Type: GrantFiled: May 23, 2006Date of Patent: February 3, 2009Assignees: University of Helsinki, Department of Chemistry, Laboratory of Analytical Chemistry, University of Helsinki, Department of Physical Science, division of Atmospheric Sciences, Finnish Meteorological InstututeInventors: Kari Hartonen, Kari Kuuspalo, Heikki Lihavainen, Pasi Aalto, Markku Rasilainen, Marja-Liisa Riekkola, Markku Kulmala, Yrjo Viisanën
-
Publication number: 20090023222Abstract: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.Type: ApplicationFiled: August 7, 2008Publication date: January 22, 2009Applicant: BAYER HEALTHCARE LLCInventors: Huan-Ping WU, Christine D. Nelson
-
Publication number: 20080311670Abstract: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first monomer has hydrophilic characteristics. The second monomer has hydrophobic characteristics. The ratio of the first monomer to the second monomer is from about 0.1:99.9 to about 99.9:0.1.Type: ApplicationFiled: October 27, 2005Publication date: December 18, 2008Inventor: Boru Zhu
-
Publication number: 20080305506Abstract: A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.Type: ApplicationFiled: August 22, 2008Publication date: December 11, 2008Applicant: GluMetrics Inc.Inventor: Jeff T. Suri
-
Publication number: 20080261255Abstract: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors.Type: ApplicationFiled: March 1, 2004Publication date: October 23, 2008Inventors: Leah Tolosa, Govind Rao, Xudong Ge
-
Patent number: 7439033Abstract: A reagent strip for measuring the concentration of glucose in whole blood has a polymer on at least one side thereof to increase the opacity thereof, thereby reducing the effect of hematocrit on the glucose determination.Type: GrantFiled: January 29, 2004Date of Patent: October 21, 2008Assignee: Bayer HealthCare LLCInventor: Karen L. Marfurt
-
Publication number: 20080248493Abstract: The present invention relates to methods and kits for detecting an analyte in a test sample using acridinium-9-carboxylate aryl esters.Type: ApplicationFiled: April 9, 2007Publication date: October 9, 2008Inventors: Phillip G. Mattingly, Maciej Adamczyk, Roy Jeffrey Brashear
-
Patent number: 7431885Abstract: A measuring device for the amperometric measurement of test strips 12, each having a test field moistenable by a liquid to be investigated and having measuring electrodes associated with the test field. The device includes at least one test strip receiver 20 for the insertion of a test strip 12, first contact elements arranged in the region of the strip receiver 20 for contacting the measuring electrodes of a test strip 12 located in the strip receiver 20, and an evaluation and control circuit. The strip receiver 20 is formed with a separate unitary housing which on its external side has second external contact elements 50 electrically connected with the first internal contact elements. The external contact elements 50 are designed for contacting opposite contact elements 16 connected with the evaluation and control circuit.Type: GrantFiled: May 23, 2007Date of Patent: October 7, 2008Assignee: LRE Medical GmbHInventors: Norbert Pöllmann, Wolfgang Heider, Genrich Siris
-
Patent number: 7432096Abstract: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.Type: GrantFiled: April 27, 2004Date of Patent: October 7, 2008Assignee: Bayer Technology Services GmbHInventors: Ruth Meissner, Walter Weichel, Rainhard Koch, Irina Bachmatova, Liucija Marcinkeviciene, Rita Meskiene, Rasa Semenaite, Vida Casaite, Rolandas Meskys
-
Publication number: 20080241966Abstract: A method and apparatus for detecting an analyte includes a sensor chamber for detecting an analyte, an analyte feed chamber, a distributor, and a controller for controlling the transport medium flow. The distributor includes an annular channel with four connections with a switchable isolating device between two connections. The controller controls the distributor for flushing the transport medium fed from the distributor to the sensor chamber without passing through the analyte feed chamber and for measuring the transport medium fed from the distributor to the sensor chamber while passing through the analyte feed chamber.Type: ApplicationFiled: June 21, 2007Publication date: October 2, 2008Applicant: TRACE ANALYTICS GMBHInventors: Wolfgang Kunnecke, Michael Hartlep, Jens Giesenberg
-
Patent number: 7417164Abstract: A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.Type: GrantFiled: July 24, 2007Date of Patent: August 26, 2008Assignee: Glumetrics Inc.Inventor: Jeff T. Suri
-
Patent number: 7407811Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.Type: GrantFiled: October 17, 2003Date of Patent: August 5, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: David W. Burke, Lance S. Kuhn, Terry A. Beaty, Vladimir Svetnik
-
Patent number: 7407626Abstract: A medical test kit includes a glucose testing composition, a protein testing composition, a bilirubin testing composition, a bilinogen testing composition, an amylase testing composition, a blood testing composition, a calcium testing composition, a nitrite testing composition, a ketone testing composition and a pH testing composition. The medical test kit also includes a plurality of corresponding indicative spectra to each of its units such that a health condition of a user can easily be interpreted. Furthermore, an interactive reference chart is provided for guiding a user for the use of the kit. The kit is suitable for use for the public and is capable of encouraging self health care of society.Type: GrantFiled: April 20, 2004Date of Patent: August 5, 2008Inventor: Qing-Hua Zhao
-
Publication number: 20080160625Abstract: A process is described for the preparation of modified electrodes useful for the measurement of analytes in biological fluids, comprising the deposition of Prussian blue on screen printed electrodes, and the modified electrodes prepared via said process; the enzymatic electrodes and the biosensors comprising said modified electrodes and the method for the determination of analytes in biological fluids which uses said modified electrodes are also described.Type: ApplicationFiled: December 13, 2007Publication date: July 3, 2008Inventors: Giuseppe Palleschi, Francesco Ricci, Danila Moscone, Alessandro Poscia
-
Patent number: 7395158Abstract: A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.Type: GrantFiled: August 13, 2002Date of Patent: July 1, 2008Assignee: Sensys Medical, Inc.Inventors: Stephen L. Monfre, Linda Hockersmith, Donald Hetzel, Kevin H. Hazen, Andrew Cone
-
Patent number: 7390667Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.Type: GrantFiled: October 17, 2003Date of Patent: June 24, 2008Assignee: Roche Diagnostics Operations, Inc.Inventors: David W. Burke, Lance S. Kuhn, Terry A. Beaty, Vladimir Svetnik
-
Patent number: 7390663Abstract: The present invention is directed toward a stable calibrator and/or control, kit and process for using in a glucose monitoring instrumentation. Principally, the instant invention teaches a glycolyzed red blood cell component which has been treated with a glycolysis stabilizing effective amount of at least one non-crosslinking aldehyde compound which may be added to fresh plasma along with an amount of glucose to form a simulated whole blood glucose control product, effective for maintaining a particular and essentially stable glucose concentration over a period of time sufficient for accurate measurement and calibration of a glucose measuring instrument.Type: GrantFiled: February 23, 2006Date of Patent: June 24, 2008Assignee: Streck, Inc.Inventors: Wayne L. Ryan, Bradford A. Hunsley
-
Publication number: 20080145944Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.Type: ApplicationFiled: November 30, 2007Publication date: June 19, 2008Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Mark Alan Mortellaro, Aneta Modzelewska
-
Patent number: 7384791Abstract: A method of analyzing blood includes delivering a blood sample to a test device, applying a spatially varying electric field to the blood sample to provide a depleted cell concentration in a portion of the blood sample, and sensing a property of the portion of the blood sample.Type: GrantFiled: January 21, 2004Date of Patent: June 10, 2008Assignee: Hewlett-Packard Development Company, L.P.Inventors: David Tyvoll, Winthrop D. Childers, Kirk Norton, Bryan J. Johnson
-
Patent number: 7374721Abstract: A chip with measuring reliability and a method thereof are provided. The present invention serially connects a resistor having a resistance equal to or a little more than a maximum resistance of the chip itself to the resistor Rs of the chip so as to compensate the resistance differences among chips. A noise to signal (N/S) ratio of the chip is decreased, and a measuring reliability of the chip is improved.Type: GrantFiled: December 4, 2003Date of Patent: May 20, 2008Assignee: Transpacific IP, Ltd.Inventors: Yin-Chun Huang, Kuo-Jeng Wang
-
Patent number: 7368085Abstract: An analyte detector including a device having a surface, wherein the device is capable of detecting a charge adjacent to the surface. The surface includes a plurality of molecules bonded thereto, wherein the molecules have a structure (I): where R is a ligand bonded to the surface of the device and R1 is a spacer having 5 to 50 carbon atoms. The charge adjacent to the surface is created by the anionic complex of structure (I), and the number of anionic complex of structure (I) is dependent on the concentration of the analyte of interest. Methods for detecting an analyte are also disclosed, as well as systems using such analyte detectors.Type: GrantFiled: December 4, 2003Date of Patent: May 6, 2008Assignee: Honeywell International Inc.Inventors: Yuandong Gu, Son Thai Lu
-
Patent number: 7338639Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.Type: GrantFiled: March 16, 2006Date of Patent: March 4, 2008Assignees: Roche Diagnostics Operations, Inc., Corange International LimitedInventors: David W. Burke, Lance S. Kuhn, Terry A. Beaty, Vladimir Svetnik
-
Patent number: 7315767Abstract: One aspect of the invention provides a device that non-invasively determines the concentration of a substance in a target. The device includes a first electrode, a measuring circuit, and a data processor. In one embodiment of the device, the first electrode can be electrically insulated from the target, e.g., a cover layer of insulating material covers the first electrode.Type: GrantFiled: September 5, 2003Date of Patent: January 1, 2008Assignee: Solianis Holding AGInventors: Andreas Caduff, Etienne Hirt, Thomas W. Schrepfer
-
Patent number: 7303922Abstract: Apparatus and method for determining at least one parameter, e. g., concentration, of at least one analyte, e. g., urea, of a biological sample, e. g., urine. A biological sample particularly suitable for the apparatus and method of this invention is urine. In general, spectroscopic measurements can be used to quantify the concentrations of one or more analytes in a biological sample. In order to obtain concentration values of certain analytes, such as hemoglobin and bilirubin, visible light absorption spectroscopy can be used. In order to obtain concentration values of other analytes, such as urea, creatinine, glucose, ketones, and protein, infrared light absorption spectroscopy can be used. The apparatus and method of this invention utilize one or more mathematical techniques to improve the accuracy of measurement of parameters of analytes in a biological sample.Type: GrantFiled: April 22, 2004Date of Patent: December 4, 2007Assignee: Abbott LaboratoriesInventors: Tzyy-Wen Jeng, Larry L. McDowell, Joseph Larry Pezzaniti, Gary M. Oosta, Eric B. Shain
-
Patent number: 7264971Abstract: A readhead for a photometric diagnostic instrument includes a housing adapted for incorporation within the photometric diagnostic instrument, and an elongated sample table operatively engaged with the housing. The sample table is configured to support elongated reagent sample media of the type having a plurality of test areas disposed in spaced relation thereon, each of the test areas being configured to react with a sample and to change color according to an amount of a constituent or property in the sample. A light source is provided to illuminate the sample table. An imager having an elongated field of view is coupled to the housing, the elongated field of view including at least a portion of the sample table. A scanning mechanism is configured to move the field of view relative to the sample table.Type: GrantFiled: July 20, 2004Date of Patent: September 4, 2007Assignee: Siemens Medical Solutions DiagnosticsInventor: Nicholas T. Stock
-
Patent number: 7255835Abstract: Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a sample; providing an internal reflecting element (IRE) with a functionalized tip; contacting the sample with the IRE to form a sample-IRE interface; directing a beam of infrared (IR) radiation through the IRE under conditions such that the IR radiation interacts with the sample-IRE interface once; recording a reflectance profile over a range of preselected frequencies, whereby an infrared spectrum of the of a sample having or suspected of having an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof, disposed in an aqueous solution is acquired.Type: GrantFiled: September 4, 2002Date of Patent: August 14, 2007Assignee: North Carolina State UniversityInventors: Stefan Franzen, Simon E. Lappi
-
Patent number: 7236812Abstract: There are many inventions described and illustrated herein. In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid (for example, a fluid sample) or matrix. The analyte may be glucose or other chemical of interest. The fluid or matrix may be, for example, the fluid or matrix in the body of an animal (for example, human), or any other suitable fluid or matrix in which it is desired to know the concentration of an analyte. In one embodiment, the invention is a system and/or device that includes one or more layers having a plurality of analyte-equivalents and mobile or fixed receptor molecules with specific binding sites for the analyte-equivalents and analytes under analysis (for example, glucose). The receptor molecules, when exposed to or in the presence of analyte (that resides, for example, in a fluid in an animal), bind with the analyte (or vice versa).Type: GrantFiled: August 27, 2004Date of Patent: June 26, 2007Assignee: BioTex, Inc.Inventors: Ralph Ballerstadt, Roger McNichols, Ashok Gowda
-
Patent number: 7198955Abstract: A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method further takes the measured concentration of the blood substitute and uses it to correct for its effect, if any, on a measured analyte concentration, e.g., serum/plasma total protein. Further, the method allows for the determination of the concentration of true hemoglobin in the presence of blood substitutes. The method is carried out in respect of samples contained in a primary or secondary labelled tube, or a pipette tip used to dispense serum or plasma in a blood analyzer.Type: GrantFiled: October 16, 1997Date of Patent: April 3, 2007Assignee: NIR Diagnostics Inc.Inventors: James Samsoondar, Duncan MacIntyre
-
Patent number: 7150997Abstract: A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method, a value corresponding to a voltage is stored in a local memory associated with each electrode. The addressed electrodes are then driven at the voltages corresponding to the stored values. In another aspect of the method, a driving element associated with each addressed electrode is selectively coupled with a voltage line so as to charge the electrode with the voltage on the voltage line. The device and methods may be used in the synthesis of biopolymers such as oligonucleotides and peptides.Type: GrantFiled: March 15, 2005Date of Patent: December 19, 2006Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
-
Patent number: 7138089Abstract: A test device for testing of analyte concentration in a fluid to be applied thereto, the device comprising a plurality of test members arranged in at least one stack and electrodes for engaging with electrode tracks on a test member. A pusher pushes a single test member from the stack so that it can engage with the electrodes. An actuation member is connected to the pusher, and moves it when operated by a user. The at least one stack of test members is enclosed in a magazine which is initially sealed by a moisture impermeable seal. A cutter is provided for slitting the seal and permitting a test member to be pushed from the magazine by the pusher when the first test member from the magazine is to be used.Type: GrantFiled: July 19, 2001Date of Patent: November 21, 2006Assignee: Hypoguard LimitedInventors: James Aitken, Andrew James Woodhead, Stuart Richard May, Murdo M. Black
-
Patent number: 7118916Abstract: Methods, devices and kits for facilitating medical diagnostic assays and reducing the time required for taking of such assays. The methods comprise initiating a reaction, obtaining at least three measurements, at three different time points, of a value or level of an observable associated with the reaction, and estimating an end point value for the observable from the measurements.Type: GrantFiled: October 21, 2002Date of Patent: October 10, 2006Assignee: Lifescan, Inc.Inventor: David Matzinger
-
Patent number: 7105352Abstract: The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of responding to glucose. The molecular recognition component may be a boronic acid, such as a phenylboronic acid, glucose oxidase, a combination of phenylboronic acid and poly(ethylene)glycol or crown ether, or another component capable of detecting glucose in various fluids and solutions. The glucose sensors of the present invention may be useful in the development of noninvasive or minimally invasive in vivo glucose sensors for patients having diabetes mellitus.Type: GrantFiled: July 1, 2002Date of Patent: September 12, 2006Assignee: University of PittsburghInventors: Sanford A. Asher, Vladimir L. Alexeev, Igor K. Lednev, Anjal C. Sharma, Craig Wilcox
-
Patent number: 7101717Abstract: An addressable biologic electrode array includes an array of electrodes disposed on a support, the array of electrodes being selectively addressed and driven using a memory associated with each electrode of the array, the driven electrodes being driven at one of a plurality of stimulus levels by a source of electrical current or voltage external to the array.Type: GrantFiled: January 23, 2004Date of Patent: September 5, 2006Assignee: Nanogen, Inc.Inventor: Gregory T. A. Kovacs
-
Patent number: 7098037Abstract: A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.Type: GrantFiled: August 16, 2002Date of Patent: August 29, 2006Assignee: InLight Solutions, Inc.Inventors: Michael J. Haas, Robert K. Rowe, Edward V. Thomas
-
Patent number: 7060503Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: GrantFiled: March 1, 2004Date of Patent: June 13, 2006Assignee: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin, Jr.