By Measuring A Physical Property (e.g., Mass, Etc.) Patents (Class 506/12)
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Publication number: 20130237454Abstract: Biomarkers for the diagnosis of neuropsychiatric diseases are presented herein. In particular embodiments, biomarkers are identified that are useful for diagnosing multiple sclerosis, chronic fatigue syndrome, or Neurologic Lyme disease. Also encompassed is a method for diagnosing a patient with a neuropsychiatric disease, such as multiple sclerosis, chronic fatigue syndrome, or Neurologic Lyme disease, by analyzing biological samples isolated from the patient or the patient as a whole to assess levels of the biomarkers described herein.Type: ApplicationFiled: May 12, 2011Publication date: September 12, 2013Inventor: Steven E. Schutzer
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Patent number: 8524450Abstract: A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis. The method can include providing a plurality of encoded microvessels. The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels.Type: GrantFiled: October 29, 2010Date of Patent: September 3, 2013Assignee: Illumina, Inc.Inventors: John A. Moon, M. Shane Bowen, Ryan C. Smith, Michel Perbost, Michal Lebl, Steven H. Modiano
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Publication number: 20130217596Abstract: An imaging system for exciting and measuring fluorescence on or in samples comprising fluorescent materials (e.g. fluorescent labels, dyes or pigments). In one embodiment, a device is used to detect fluorescent labels on nucleic acid. In a preferred embodiment, the device is configured such that fluorescent labels in a plurality of different DNA templates are simultaneously detected.Type: ApplicationFiled: February 16, 2012Publication date: August 22, 2013Inventors: Steven Gordon, Steven Auger, Alan Schinazi
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Publication number: 20130210672Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.Type: ApplicationFiled: August 14, 2012Publication date: August 15, 2013Applicant: STC.UNMInventors: Larry A. Sklar, Bruce S. Edwards, Frederick W. Kuckuck
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Publication number: 20130210666Abstract: Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.Type: ApplicationFiled: August 16, 2011Publication date: August 15, 2013Applicant: Mount Sinai HospitalInventors: Keith Jarvi, Eleftherios P. Diamandis, Andrei Drabovich
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Publication number: 20130210652Abstract: The present invention relates to an apparatus to detect biological parameters in the analysis of a sample, specimen, or assay. The system includes a device for determining one or more values for one or more measurable characteristics of a sample. In an aspect, the device can be configured to operate on any of a mobile device, tablet computer, laptop computer, desktop computer, digital pen, medical testing tool or electronic device. In another aspect, the device can comprise a synchronization component that synchronizes the device to a network system.Type: ApplicationFiled: November 1, 2012Publication date: August 15, 2013Applicant: NANOAXIS, LLCInventors: Krishnan Chakravarthy, Siddhartha Kamisetti, Himanshu Subhash Amin
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Publication number: 20130203709Abstract: The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in the presence of a biological target protein, a Bcl-2 family protein, to form the acylsulfonamide.Type: ApplicationFiled: August 9, 2011Publication date: August 8, 2013Applicants: THE PENN STATE RESEARCH FOUNDATION, UNIVERSITY OF SOUTH FLORIDAInventors: Roman Manetsch, Sameer Kulkarni, Iredia D. Iyamu, Hong-Gang Wang, Kenichiro Doi, Wayne Guida, Daniel Santiago, Courtney du Boulay
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Publication number: 20130190189Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.Type: ApplicationFiled: January 3, 2013Publication date: July 25, 2013Applicant: Medical Research CouncilInventor: Medical Research Council
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Publication number: 20130189287Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs.Type: ApplicationFiled: December 21, 2012Publication date: July 25, 2013Applicants: Innate PharmaInventors: Innate Pharma, Paul Scherrer Institut
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Publication number: 20130184180Abstract: The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially.Type: ApplicationFiled: December 19, 2012Publication date: July 18, 2013Applicant: MOMENTA PHARMACEUTICALS, INC.Inventor: Momenta Pharmaceuticals, Inc.
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Publication number: 20130184173Abstract: Biomarkers that can be used for the diagnosis and prognosis of multiple sclerosis in pediatric patients presenting with clinically isolated syndrome or acquired demyelination syndrome are described.Type: ApplicationFiled: April 14, 2011Publication date: July 18, 2013Applicant: The Royal Institution for the Advancement of Learning/Mcgill UniversityInventors: Amit Bar-Or, Elizabeth Colman, Katja Geling
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Publication number: 20130184181Abstract: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination and/or quantification by mass spectrometry using compounds comprising a reporter moiety and a non-encoded detectable label. The compounds can be used in sets for the analysis of mixtures of labeled analytes.Type: ApplicationFiled: December 20, 2012Publication date: July 18, 2013Inventors: Subhasish Purkayastha, Subhakar Dey
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Publication number: 20130178395Abstract: Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.Type: ApplicationFiled: March 4, 2013Publication date: July 11, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: Life Technologies Corporation
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Publication number: 20130165346Abstract: A continuous throughput microfluidic system includes an input system configured to provide a sequential stream of sample plugs; a droplet generator arranged in fluid connection with the input system to receive the sequential stream of sample plugs and configured to provide an output stream of droplets; a droplet treatment system arranged in fluid connection with the droplet generator to receive the output stream of droplets in a sequential order and configured to provide a stream of treated droplets in the sequential order; a detection system arranged to obtain detection signals from the treated droplets in the sequential order; a control system configured to communicate with the input system, the droplet generator, and the droplet treatment system; and a data processing and storage system configured to communicate with the control system and the detection system.Type: ApplicationFiled: December 7, 2012Publication date: June 27, 2013Applicant: The Johns Hopkins UniversityInventor: The Johns Hopkins University
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Publication number: 20130158021Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.Type: ApplicationFiled: October 26, 2012Publication date: June 20, 2013Applicant: Massachusetts Institute of TechnologyInventor: Massachusetts Institute of Technology
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Publication number: 20130157891Abstract: The present application provides novel compositions, methods, and assays for use in identification of appropriate diagnostic markers in blood. These compositions, methods, and assays are capable of distinguishing normal levels of detectable markers from changes in marker levels that are indicative of changes in health status.Type: ApplicationFiled: June 24, 2011Publication date: June 20, 2013Inventors: Xiao-Jun Li, Paul Edward Kearney
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Publication number: 20130157896Abstract: A nanoscale calcinated silicate film fabricated on a gold substrate for highly effective, matrix-free laser desorption ionization mass spectrometry (LDI-MS) analysis of biomolecules. The calcinated film is prepared by a layer-by-layer (LbL) deposition/calcination process wherein the thickness of the silicate layer and its surface properties are precisely controlled. The film exhibits outstanding efficiency in LDI-MS with extremely low background noise in the low-mass region, allowing for effective analysis of low mass weight samples and detection of large biomolecules including amino acids, peptides and proteins. Additional advantages for the calcinated film include ease of preparation and modification, high reproducibility, low cost and excellent reusability.Type: ApplicationFiled: May 18, 2011Publication date: June 20, 2013Applicant: The Regents of the University of CaliforniaInventors: Quan Cheng, Jicheng Duan, Matthew James Linman
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Publication number: 20130150261Abstract: The present invention provides a unique profile of volatile organic compounds as breath biomarkers for lung cancer. The present invention further provides the diagnosis, prognosis and monitoring of lung cancer or predicting the response to an anti-cancer treatment through the detection of the unique profile of volatile organic compounds indicative of lung cancer at its various stages.Type: ApplicationFiled: November 15, 2012Publication date: June 13, 2013Applicants: Tel Hashomer Medical Research, Infrastructure and Services Ltd., Technion Research and Development Foundation Ltd.Inventors: Technion Research and Development Foundation Ltd., Tel Hashomer Medical Research, Infrastructure and Services Ltd.
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Publication number: 20130143768Abstract: A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage.Type: ApplicationFiled: July 6, 2012Publication date: June 6, 2013Applicant: Northwestern UniversityInventors: CHRISTOPHER E. WILMER, Michael Leaf, Randall Q. Snurr, Omar K. Farha, Joseph T. Hupp
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Publication number: 20130143755Abstract: Aspects of the present invention include methods for determining a transplant category of a subject having a transplant. Common mechanisms of rejection injury are uncovered across different tissue transplants, and provide a means to understand rational drug design. Various sources of tissues are examined form the patient for understanding AR mechanism (graft biopsy), as well as monitoring by minimal invasive means (blood) or non-invasive means (urine for the kidney allograft). For biomarker discovery different categories of markers are examined such as genes, proteins, peptides and antibodies. These biomarkers can help determine the subject's transplant category (e.g., acute allograft rejection (AR), stable allograft (STA), BK viremia, BK nephritis, drug toxicity or chronic allograft injury (CAI), and the like). Also provided are compositions, systems, kits and computer program products that find use in practicing the subject methods. The methods and compositions find use in a variety of applications.Type: ApplicationFiled: March 25, 2011Publication date: June 6, 2013Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Minnie M. Sarwal, Tara Sigdel, Amit Kaushal, Li Li, Wenzhong Xiao, Atul J. Butte, Purvesh Khatri
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Publication number: 20130130936Abstract: The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties.Type: ApplicationFiled: January 10, 2013Publication date: May 23, 2013Applicant: ADVANCED LIQUID LOGIC, INC.Inventor: ADVANCED LIQUID LOGIC, INC.
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Publication number: 20130123144Abstract: Polymer compositions having the chemical structure: as well as monomer compositions for producing said polymers are described. Methods for preparing these polymers and combinatorial libraries of these polymers are also described.Type: ApplicationFiled: May 6, 2011Publication date: May 16, 2013Applicant: CORNELL UNIVERSITYInventors: David Putnam, Lihong Huang
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Publication number: 20130116148Abstract: Disclosed is a method for promptly identifying a liver disease. A normal person or a liver disease such as drug-induced liver injury, asymptomatic hepatitis B carrier, chronic hepatitis B, hepatitis C with persistently normal ALT, chronic hepatitis C, cirrhosis type C, hepatocellular carcinoma, simple steatosis, or non-alcoholic steatohepatitis is identified by measuring the concentration of a ?-Glu-X (wherein X represents an amino acid or an amine) peptide or the level of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.Type: ApplicationFiled: May 17, 2011Publication date: May 9, 2013Applicant: KEIO UNIVERSITYInventors: Tomoyoshi Soga, Masahiro Sugimoto, Makoto Suematsu, Takafumi Saito, Sumio Kawata
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Publication number: 20130116137Abstract: A disclosed chemical detection system for detecting a target material, such as an explosive material, can include a cantilevered probe, a probe heater coupled to the cantilevered probe, and a piezoelectric element disposed on the cantilevered probe. The piezoelectric element can be configured as a detector and/or an actuator. Detection can include, for example, detecting a movement of the cantilevered probe or a property of the cantilevered probe. The movement or a change in the property of the cantilevered probe can occur, for example, by adsorption of the target material, desorption of the target material, reaction of the target material and/or phase change of the target material. Examples of detectable movements and properties include temperature shifts, impedance shifts, and resonant frequency shifts of the cantilevered probe. The overall chemical detection system can be incorporated, for example, into a handheld explosive material detection system.Type: ApplicationFiled: July 2, 2012Publication date: May 9, 2013Applicant: Board of Regents of the Nevada System of Higher Education, on behalf of the University of NevadaInventors: Jesse D. Adams, Todd A. Sulchek, Stuart C. Feigin
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Publication number: 20130109592Abstract: Methods to determine the absence or presence of one or more cancer types in an animal are disclosed herein. In some embodiments, amounts of lipids in a sample (e.g., a bodily fluid or treatment thereof) from the animal are used with a predictive model to make the determination. The lipid amounts can be measured, in some instances, using a mass spectrometry system.Type: ApplicationFiled: June 22, 2011Publication date: May 2, 2013Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: Teresa Whei-Mei Fan, Andrew Nicholas Lane, Richard M. Higashi, Michael Bousamra
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Publication number: 20130096030Abstract: The present invention relates to a multisensor array for detection of analytes in the gas phase or in the liquid phase, comprising at least two different chemo-selective compounds represented by the general formula (I) wherein the hetero atoms X1-X4 and the substituents R1-R4 are defined in the specification and the dashed bonds represent independently of each other either a single bond or a double bond. Said chemo-selective compounds are capable of individually changing physicochemical properties when exposed to analytes or analyte mixtures and these changes can be detected by a transducer or an array of transducers. The present invention does also relate to the use of at least two different chemo-selective compounds in a sensor array, a method for preparation of such sensor arrays and the use of said sensor arrays. Furthermore the present invention relates to methods for detecting and identifying analytes or mixtures thereof in the gas phase or in the liquid phase.Type: ApplicationFiled: March 31, 2011Publication date: April 18, 2013Applicants: SYDDANSK UNIVERSITET, DANMARKS TEKNISKE UNIVERSITETInventors: Jan Oskar Jeppesen, Natalie Kostesha, Carsten Johnsen, Kent Albin Nielsen, Anja Boisen, Mogens Havsteen Jakobsen
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Publication number: 20130079247Abstract: A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.Type: ApplicationFiled: November 21, 2012Publication date: March 28, 2013Applicant: SEQUENOM, INC.Inventor: SEQUENOM, INC.
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Publication number: 20130065769Abstract: Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included.Type: ApplicationFiled: September 7, 2012Publication date: March 14, 2013Applicant: The Regents of the University of CaliforniaInventor: David T. WONG
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Publication number: 20130064799Abstract: The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency. Key kinases are identified and key regulation networks involving such kinases are also identified that may be advantageously targeted to significantly increase reprogramming efficiency as well as direct differentiation of induced pluripotent stem (iPS) cells.Type: ApplicationFiled: May 31, 2012Publication date: March 14, 2013Inventor: Tariq M. Rana
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Publication number: 20130059743Abstract: A microarray with optically recorded information and a sample capable of producing a signal as a response to external influence, or a precursor which, when activated or combined with a reagent, produces a sample capable of generating a signal. The microarray is compatible with a dual functionality optical drive. A method for acquiring information about a sample comprises directing a probe to a sample at a microarray to produce a signal from the sample, wherein the microarray is compatible with a dual functionality optical drive, and detecting the signal. The information optically recorded on the microarray can be in the CD, DVD or HD DVD or Blue Ray format.Type: ApplicationFiled: February 29, 2012Publication date: March 7, 2013Inventor: Alexey V. ELISEEV
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Publication number: 20130059750Abstract: The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder.Type: ApplicationFiled: January 28, 2011Publication date: March 7, 2013Applicant: PSYNOVA NEUROTECH LTD.Inventors: Sabine Bahn, Marlis Huebner
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Publication number: 20130059758Abstract: The present invention provides a method for detecting and grading benign and malignant tumors using at least one sensor of conductive nanoparticles capped with an organic coating in conjunction with a learning and pattern recognition algorithm. The method utilizes a plurality of response induced parameters to obtain improved sensitivity and selectivity for diagnosis, prognosis, monitoring and staging various types of cancers, or for identifying or grading benign or malignant tumors.Type: ApplicationFiled: May 22, 2011Publication date: March 7, 2013Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.Inventors: Hossam Haick, Gregory Shuster
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Publication number: 20130053263Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: December 30, 2010Publication date: February 28, 2013Applicant: FEBIT HOLDING GMBHInventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
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Publication number: 20130052172Abstract: The present disclosure defines a method for identifying and/or treating risk and/or occurrence of cardiac defect. As is shown herein, microbiomes are reproducibly and detectably associated with cardiac defect risk factors and changes to the microbiome can directly alter cardiac defect risk. The present disclosure demonstrates that microbial signatures can be used to characterize components of microbiomes that associate with altered risk or occurrence of cardiac defects and to identify treatments to reduce risk or severity of cardiac defects.Type: ApplicationFiled: April 7, 2012Publication date: February 28, 2013Inventor: John Edward Baker
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Publication number: 20130045873Abstract: The present invention relates generally to methods for identifying organ-specific secreted proteins and for identifying organ-specific molecular blood fingerprints therefrom. As such, the present invention provides compositions comprising such proteins, detection reagents for detecting such proteins, and panels, and arrays for determining organ-specific molecular blood fingerprints.Type: ApplicationFiled: August 8, 2012Publication date: February 21, 2013Applicant: Institute For Systems BiologyInventors: Leroy HOOD, Biaoyang LIN
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Publication number: 20130040848Abstract: The invention relates to a method of detecting a structural change in a molecule, said molecule being attached to a surface, said surface being electrically conductive, wherein the phase of the electrochemical impedance at said surface is monitored, and wherein a change in the phase in the electrochemical impedance at said surface indicates a change in the structure of said molecule. The invention further relates to methods for making arrays having molecules such as, polypeptides attached to electrically conductive surfaces such as electrodes, and to arrays.Type: ApplicationFiled: September 28, 2012Publication date: February 14, 2013Applicants: MEDICAL RESEARCH COUNCIL, UNIVERSITY OF LEEDSInventors: University of Leeds, Medical Research Council
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Publication number: 20130040857Abstract: Methods for interpretation of mass spectrometric tests for clinical biomarkers in which the amounts of internal standards are set to equal clinical evaluation thresholds, and preparations for adding stable isotope labeled peptide species to sample digests while minimizing losses and alterations in peptide stoichiometry.Type: ApplicationFiled: March 15, 2011Publication date: February 14, 2013Applicant: ANDERSON FORSCHUNG GROUP, INC.Inventor: Norman Leigh Anderson
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Publication number: 20130039887Abstract: Disclosed herein are methods for identifying compounds for the treatment of viral infection, including RNA viral infection and uses of the compounds as pharmaceutical compositions. The identified compounds modulate the RIG-I pathway in vertebrate cells.Type: ApplicationFiled: April 20, 2011Publication date: February 14, 2013Applicant: KINETA, INC.Inventors: Shawn P. Iadonato, Kristin Bedard, Michael Gale
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Publication number: 20130035251Abstract: MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.Type: ApplicationFiled: December 30, 2010Publication date: February 7, 2013Applicant: febit holding GmbHInventors: Andreas Keller, Eckart Meese, Anne Borries, Markus Beier
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Publication number: 20130029857Abstract: A method of identifying alleles of polymorphic sites in a plurality of nucleic acid samples including the steps of determining a source tag sharing number “d” for each of the alleles; performing a first reaction in a plurality of pools of the alleles to be identified to produce reaction products including a source tag identifying said each pool; pooling the pools to provide pooled pools; for each of the alleles to be identified, performing a second reaction using said reaction products to produce allele-specific second reaction products comprising a marker tag and a derived source tag; identifying said allele-specific second reaction products to identify the alleles. If “d” is equal to or larger than a maximum pool size, the first reaction may not be performed. Alleles may be binned together. A microparticle comprising one or more capture probes each comprising an oligonucleotide complementary to a subsequence of a target polynucleotide.Type: ApplicationFiled: July 25, 2011Publication date: January 31, 2013Applicant: Bioinventors & Entrepreneurs Network, LLCInventor: Michael Seul
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Publication number: 20130023444Abstract: Provided herein are novel reagents and their use in color-producing detection systems for performing diagnostic tests and analytical assays.Type: ApplicationFiled: May 23, 2012Publication date: January 24, 2013Applicant: Diagnostic Innovations, LLCInventor: Victor Kovalenko
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Publication number: 20130017970Abstract: The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder.Type: ApplicationFiled: December 20, 2010Publication date: January 17, 2013Applicant: Psynova Neurotech Ltd.Inventors: Sabine Bahn, Yishai Levin, Emanuel Schwarz
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Publication number: 20130012414Abstract: The invention describes methods that use nanostructures and quantum confinement to detect and manipulate chemical and biochemical molecules. To increase selectivity and sensitivity nanostructures are built to have the density of states similar to that in analyte that will be detected and operated. Using device that incorporates such nanostructures, measuring electrical and optical properties of nanostructures and analyte or charge and energy transfer between the nanostructures and analyte a rapid and sensitive continuous detection in fluids can be achieved. Detection can be further enhanced by controlling external environmental parameters and applying external fields. In addition to be detected analyte can be positioned, moved, separated, extracted, and controlled.Type: ApplicationFiled: September 10, 2012Publication date: January 10, 2013Inventors: Branislav Vlahovic, Vanja Vlahovic Malloy
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Publication number: 20120329676Abstract: A high throughput screening system and method of an acid-producing microorganism using a mixture of at least two pH indicators are provided. The method may be useful in determining a production amount of an acid, which is a final metabolite secreted by the microorganism, more accurately, rapidly and easily.Type: ApplicationFiled: February 22, 2012Publication date: December 27, 2012Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Hwa Young CHO, Byung Jo YU, Jae Chan PARK, Sung Min PARK, Hyun Min KOO, Ju Young LEE
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Patent number: 8334238Abstract: The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.Type: GrantFiled: April 16, 1999Date of Patent: December 18, 2012Assignee: Rigel, Inc.Inventors: Joseph Fisher, James Lorens, Donald Payan, Alexander Rossi
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Publication number: 20120308650Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.Type: ApplicationFiled: June 4, 2012Publication date: December 6, 2012Inventors: Arturo J. Vegas, Minglin Ma, Kaitlin M. Bratlie, Daniel G. Anderson, Robert S. Langer
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Patent number: 8318896Abstract: A method for multi-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a first liquid chromatography stationary phase or a field flow fractionation device and subsequently flowing the solution through a second liquid chromatography stationary phase, the second liquid chromatography stationary phase comprising graphitic carbon, the polyolefin polymer emerging from the liquid chromatography stationary phase with a retention factor greater than zero.Type: GrantFiled: December 21, 2009Date of Patent: November 27, 2012Assignee: Dow Global Technologies LLCInventors: William L. Winniford, Rongjuan Cong, Theodore M. Stokich, Jr., Randy J. Pell, Matthew D. Miller, Abhishek Roy, Freddy Van Damme, Alexander W. Degroot, John W. Lyons, David M. Meunier
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Publication number: 20120283137Abstract: A reactive mass label for labelling a biological molecule for detection by mass spectrometry, which label comprises a reactive functionality for labelling thiol groups or carbonyl groups. Also provided is a reactive mass label for labelling a biological molecule for detection by mass spectrometry, wherein the mass label comprises the following structure: X-L-M-S-Re wherein X is a mass marker moiety, L is a cleavable linker, M is a mass normalization moiety, S is a mass series modifying group comprising the following group: wherein J is C?O, K is NH, and n is 2 or J and K are both CH2 and n is 1, and wherein m is at least 1; and Re is a reactive functionality for attaching the mass label to a biological molecule.Type: ApplicationFiled: September 8, 2010Publication date: November 8, 2012Applicant: ELECTROPHORETICS LIMITEDInventors: Christian Baumann, Stefan Kienle, Karsten Kuhn, Harald Legner
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Publication number: 20120277119Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.Type: ApplicationFiled: June 13, 2012Publication date: November 1, 2012Applicant: SEQUENOM, INC.Inventors: Mathias EHRICH, Anders Olof Herman Nygren
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Publication number: 20120238472Abstract: The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems.Type: ApplicationFiled: June 1, 2012Publication date: September 20, 2012Applicant: LUMENCOR, INC.Inventors: Claudia B. Jaffe, Steven M. Jaffe, Michieal L. Jones