The Hetero Ring Has Exactly 15 Ring Carbons Patents (Class 514/30)
  • Patent number: 10765657
    Abstract: The invention describes a method for treating a parasitic infection or infestation, particularly sea lice, in a fish by administering an effective amount of selamectin.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: September 8, 2020
    Assignee: Zoetis Services LLC
    Inventors: John Adam Wendt, David Jose Asper, Stacy Ross
  • Patent number: 10694742
    Abstract: A composition having a pesticide and a hydroxyalkyl polyoxylene glycol ether of the general formula (I) where R1 is a saturated or unsaturated, linear or branched alkyl having 6 to 18 carbon atoms; R2 is ethylene, propylene, butylene or a mixture thereof; R3 is a saturated or unsaturated, linear or branched alkyl having 6 to 18 carbon atoms; and n has a value of from 1 to 100. The composition may be used as an adjuvant in in pesticide-comprising spray mixtures. In a method for controlling phytopathogenic fungi and/or undesirable plant growth and/or undesirable insect or mite infestation and/or for regulating the growth of plants, the composition is allowed to act on the respective pests, the habitat thereof or the plants to be protected from the respective pest, on the soil and/or on undesirable plants and/or the crop plants and/or the habitat thereof. Seed may also include the composition.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: June 30, 2020
    Assignee: BASF SE
    Inventors: Martin Semar, Ingo Fleute-Schlachter, Hans-Christian Raths, Markus Kalt, Rainer Berghaus
  • Patent number: 10548911
    Abstract: Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a recombinant gene that expresses a detectable expression product in a dose-dependent response to TGF?, as well as methods of identifying a compound that inhibits TGF?-mediated expression of the detectable expression product.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: February 4, 2020
    Assignee: University of Rochester
    Inventors: Richard P. Phipps, Collynn Woeller
  • Patent number: 10376492
    Abstract: A compound is described that is selected from among macrocyclic lactones for treating and/or preventing a complication from a human papillomavirus infection. The complication to be treated and/or prevented can be selected from among malignant melanomas, skin carcinomas, in situ or invasive carcinomas, epidermoid carcinomas, Bowen's disease, head and neck cancers, upper aerodigestive tract cancers, laryngeal cancers, esophageal cancers, stomach cancers, oral papillomas, pharyngeal papillomas, laryngeal papillomas, esophageal papillomas, lung cancers, intravulval neoplasias, intravaginal neoplasias, intracervical neoplasias, cervical dysplasias, cervical carcinomas, penile cancer, intrapenile neoplasias, and in situ or invasive anal carcinomas.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 13, 2019
    Assignee: GALDERMA S.A.
    Inventor: Jean Jacovella
  • Patent number: 10350196
    Abstract: The invention describes a long-acting injectable veterinary composition comprising a spirocyclic isoxazoline, at least one biopolymer, and optionally, at least one veterinary acceptable-carrier, -solvent, -excipient, or any mixture thereof. The invention also includes a method of treating an animal with a parasitic infestation by administering the biopolymeric composition to the animal in need thereof, and a process for preparing the biopolymeric composition.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: July 16, 2019
    Assignee: Zoetis Services LLC
    Inventors: Todd P. Foster, Laibin Luo
  • Patent number: 10307405
    Abstract: The present invention is directed to stabilized compositions comprising at least one macrocyclic lactone, or derivative thereof, in combination with levamisole, and an amino sugar stabilizing agent, optionally an additional antiparasitic agent, and a method for treating or controlling a parasitic infection or infestation in an animal by administering said composition.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: June 4, 2019
    Assignee: Zoetis Services LLC
    Inventors: Guy Francis de Rose, Sachin Pundlik Kolhe
  • Patent number: 10252977
    Abstract: The present invention relates to halogen-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to an agrochemical formulation for this purpose, comprising the halogen-substituted phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: April 9, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Stefan Hillebrand, Mazen Es-Sayed, Joerg Greul, Ulrike Wachendorff-Neumann, Juergen Benting, Stephane Brunet
  • Patent number: 10058538
    Abstract: The present invention relates to compositions for facilitating absorption and distribution of ?2-adrenergic agonists, where said composition comprises a substituted benzofuroquinolizine and a ?2-adrenoceptor agonist selected from substituted imidazoles and substituted thiazines and the composition is administered using parenteral extravascular administration to a subject in need of sedation.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: August 28, 2018
    Assignee: VETCARE OY
    Inventors: Outi Vainio, Marja Raekallio, Juhana Honkavaara, Flavia Restitutti, Heta Turunen
  • Patent number: 10053485
    Abstract: Described herein are new anti-cancer compounds and methods of using such compounds, acting through a new mechanism of action by simultaneous inhibition of leukemia inhibitory factor (LIF) and MDM2.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 21, 2018
    Assignee: Evestra, Inc.
    Inventors: Hareesh Nair, Bindu Santhamma, Klaus Nickisch
  • Patent number: 10052340
    Abstract: The present invention relates to the new use of antiparasitic agents, such as ivermectin, abamectin/avermectin, doramectin and so on, and the design method of the derivatives for the new use. The said compounds including macrolide abamectin/avermectin, ivermectin, doramectin and the derivatives thereof, may be used in the manufacture of a medicament for use in treating metabolic related diseases in a mammal, such as hyperglycemia, insulin resistance, hypertriglyceridemia, hypercholesterolemia, diabetes, obesity, etc, and Famesoid X receptor mediated diseases, such as cholestasia, gallstone, non alcohol fatty liver disease, atherosclerosis, inflammation, cancer, etc.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: August 21, 2018
    Assignee: XIAMEN UNIVERSITY
    Inventors: Yong Li, Lihua Jin, Xuhui Feng
  • Patent number: 9974751
    Abstract: A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: May 22, 2018
    Assignee: Cima Labs Inc.
    Inventors: Walid Habib, Ehab Hamed, Derek Moe, Carrie Kraling, Lisa Hillman
  • Patent number: 9913472
    Abstract: Agrochemical formulations for treating plants, which formulations comprise, as cosolvent, polyethylene glycol (average molecular weights ranging from 200 to 400) or polypropylene glycol (average molecular weights ranging from 300 to 400) or mixtures, and, if appropriate, further additives, a process for preparing these formulations, their use for treating plants and/or their habitat and for increasing the efficacy and plant compatibility of these formulations, and for reducing volatile emission potential of these formulations.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: March 13, 2018
    Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED
    Inventors: James TImothy Bristow, Yifan Wu
  • Patent number: 9872497
    Abstract: A pesticidal mixture including (a) spinetoram; and (b) a compound of group A selected from novaluron, pyriproxyfen, tau-fluvalinate, and a combination thereof.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: January 23, 2018
    Assignee: MAKHTESHIM CHEMICAL WORKS LTD.
    Inventors: Assaf Dotan, Tamar Danon
  • Patent number: 9782425
    Abstract: Methods and compositions for safe and effective treatment of papulopustular rosacea in a subject are described. The methods involve topically applying to an affected skin area a topical composition containing ivermectin and a pharmaceutically acceptable carrier. Treatment with ivermectin represents an innovative therapy that is more robust and effective than the conventional treatments.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: October 10, 2017
    Assignee: Galderma S.A.
    Inventors: Jean Jacovella, Jean-Paul Chappuis, Alexandre Kaoukhov, Michael Graeber, Laurence Salin, Michel Poncet, Philippe Briantais
  • Patent number: 9771389
    Abstract: The present invention relates to new macrolide derivatives, in particular new tylosin derivatives of the formula (IIa), a pharmaceutical or veterinary composition comprising the derivatives; a method for preparation thereof; a method for treating and/or preventing bacterial infections in an animal, wherein the method comprises administering the derivatives or the composition; and a use of the derivatives for the manufacture of medicaments for treating and/or preventing bacterial infections in an animal.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: September 26, 2017
    Assignees: THE KITASAKO INSTITUTE, BAYER ANIMAL HEALTH GMBH
    Inventors: Gerd Kleefeld, Robrecht Froyman, Carolin Ludwig, Satoshi Omura, Toshiaki Sunazuka, Hirose Tomoyasu, Sugawara Akihiro, Shiomi Kazuro
  • Patent number: 9686991
    Abstract: The present invention relates to isothiazoline compounds of formula (I). The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to veterinary compositions comprising said compounds.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 27, 2017
    Assignee: Avista Pharma Solutions, Inc.
    Inventors: Jason D. Speake, Joe B. Perales, Weiming Fan, Solène Clarisse Rolland
  • Patent number: 9662309
    Abstract: The present invention relates to the use of macrocyclic lactones for treating demodicosis, particularly in dogs.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: May 30, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Josef Heine, Klemens Krieger
  • Patent number: 9597285
    Abstract: The present invention relates to a chewable formulation for delivering a nutritional or pharmaceutically active agent to an animal target. The chewable formulation comprises a nutritional ingredient or an effective amount of a pharmaceutically active agent, and a plasticizer. The chewable formulation is formed by extrusion and the formulation contains substantially no unbound water, nor is any water added in the manufacturing process. The present invention also relates to a method of manufacturing a shelf stable chewable formulation which comprises mixing the nutritional or pharmaceutically active agent with a fat, lipid or fat and lipid to obtain a first composition, adding one or more plasticizers to the first mixture to obtain a second composition, extruding the second composition at a temperature sufficient to melt the fat and lipid, and allowing the extruded second composition to cool to room temperature thereby providing the chewable formulation.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: March 21, 2017
    Assignee: Argenta Manufacturing Limited
    Inventors: Douglas Robert Cleverly, David Anthony Gill, Keryn Davies, Priyanka Agarwal, Su Win, Gopinath Devaraj
  • Patent number: 9598389
    Abstract: Provided are compounds of formula (I) and methods of controlling insects, acarines, nematodes or molluscs, which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: March 21, 2017
    Assignee: Syngenta Participations AG
    Inventors: Long Lu, Jerome Yves Cassayre, Torsten Luksch, Myriem El Qacemi, Guillaume Berthon, Yaming Wu
  • Patent number: 9587220
    Abstract: The present invention relates to a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing one or more WNT signaling activators, and (2) culturing a cell produced in the step (1) in a medium containing one or more WNT signaling inhibitor.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: March 7, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Norio Nakatsuji, Itsunari Minami, Motonari Uesugi, Kazuhiro Aiba
  • Patent number: 9572803
    Abstract: A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated particles may include a fat/wax and have improved controlled release and/or crush resistance. Method of making these coated particulate and dosage forms therewith are also described.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: February 21, 2017
    Assignee: Cima Labs Inc.
    Inventors: Walid A. Habib, Ehab Hamed, Manuel A. Vega Zepeda
  • Patent number: 9549918
    Abstract: The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a stabilizing agent capable of providing a pH below 7 in the composition, as measured after re-dispersion in water, and preventing or reducing the formation upon storage of major degradation products of tacrolimus, in particular the 8-epitacrolimus.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: January 24, 2017
    Assignee: VELOXIS PHARMACEUTICALS A/S
    Inventors: Nikolaj Skak, Per Holm
  • Patent number: 9439431
    Abstract: The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) wherein A1, A2, L, p, R1, R2, R3, R4 and R5 are as defined in claim 1 and component B is a fungicide. The present invention also relates to methods of using said mixtures for the control of plant pests.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: September 13, 2016
    Assignee: Syngenta Participations AG
    Inventors: Jerome Yves Cassayre, Myriem El Qacemi
  • Patent number: 9409920
    Abstract: A purification process of emamectin benzoate and compositions comprising the same. The method for purifying emamectin benzoate comprising steps (a): crystallizing emamectin benzoate in a mixture of polar solvent and non-polar solvent; isolating emamectin benzoate crystals; recovering the solvents by distillation; and recovering a crude emamectin benzoate from the solvents; (b): crystallizing emamectin benzoate crystals from step (a) in a polar aprotic solvent; isolating the crystals; recovering the solvents by distillation; and then collecting a crude emamectin benzoate from the solvents; (c): crystallizing emamectin benzoate crystals collected from step (b) in the mixture of polar solvent and non-polar solvent; isolating the crystals; recovering the solvents by distillation; and collecting a crude emamectin benzoate; wherein the purity of the crystals obtained from step (c) is 99%.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: August 9, 2016
    Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED
    Inventor: James Timothy Bristow
  • Patent number: 9402399
    Abstract: The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) wherein A1, A2, L, p, R1, R2, R3, R4 and R5 are as defined in claim 1 and component B is an insecticide. The present invention also relates to methods of using said mixtures for the control of plant pests.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: August 2, 2016
    Assignee: Syngenta Participations AG
    Inventors: Myriem El Qacemi, Jerome Yves Cassayre
  • Patent number: 9393193
    Abstract: The present invention relates to ivermectin formulations for administration to pet and domestic animals. These formulations provide long term protection against Dirofilaria parasites, without the risks for secondary adverse of conventional formulations. Preferred formulations are collars, collar strips, or medallions, attachments for collars, ear tags, bands which are affixed to limbs or parts of the body, adhesive strips and films, and peel-off films, or spot-on or pour-on forms which are administered at least twice a year up to around once a year.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: July 19, 2016
    Assignee: CEVA SANTA ANIMALE
    Inventors: Patrick Forget, Vassilios Kaltsatos, Stephan Warin
  • Patent number: 9370481
    Abstract: The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: June 21, 2016
    Assignee: Vecta, Ltd.
    Inventors: Aleksey Kostadinov, David Ayelet, Sabina Glozman, Tal Atarot
  • Patent number: 9351988
    Abstract: The present invention is directed to the use of macrocyclic lactones, in particular avermectins, in the treatment of conditions whose formation, occurrence, development or growth is associated with aberrant Wnt signalling, in particular the treatment of colorectal cancer.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: May 31, 2016
    Assignee: UNIVERSITE DE GENEVE
    Inventors: Ariel Ruiz Altaba, Christophe Mas
  • Patent number: 9339505
    Abstract: The present invention provides a combination product comprising a component A and a component B, wherein component A is a compound of formula (I) wherein A1, A2, L, p, R1, R2, R3, R4 and R5 are as defined in claim 1 and component B is a further therapeutic agent; wherein the combination product is for use in a method of therapeutic treatment.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: May 17, 2016
    Assignee: Syngenta Participations AG
    Inventors: Jerome Yves Cassayre, Myriem El Qacemi
  • Patent number: 9271947
    Abstract: A method for reducing parasites in aquatic animals is provided. The method includes reducing a plurality of parasites infecting an aquatic animal by administrating to the aquatic animal a compound comprising propyl propane thiosulfonate (PTSO) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 2. In yet a different embodiment, a method for reducing a plurality of parasites infecting an aquatic animal includes administrating to the aquatic animal a compound comprising and propyl propane thiosulfinate (PTS) having the formula R—SOa-S—R, where R represents n-propyl group (—CH2—CH2—CH3) and a is 1. In even yet another embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTS. In a different embodiment, a method for preventing a plurality of parasites in aquatic animals is provided and includes administrating to an aquatic animal a compound including PTSO.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: March 1, 2016
    Assignee: Investfood, LLC
    Inventors: Cristina Núñez Lechado, Alberto Baños Arjona, Enrique Guillamón Ayala, Adela Valero López, Ma Concepción Navarro Moll, Ana Sanz Rus
  • Patent number: 9233100
    Abstract: This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: January 12, 2016
    Assignee: MERIAL, INC.
    Inventors: Mark David Soll, Diane Larsen, Susan Mancini Cady, Peter Cheifetz, Izabela Galeska, Saijun Gong
  • Patent number: 9198430
    Abstract: This invention relates to a veterinary antiparasitic solubilized composition including a macrocyclic lactone or a pharmaceutically equivalent salt thereof, and levamisole or a pharmaceutically equivalent salt thereof, characterized in that the pH of the composition is in the range of 2.0 to 5.0 and wherein the composition includes at least one surfactant and at least one antioxidant.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: December 1, 2015
    Assignee: BAYER NEW ZEALAND LIMITED
    Inventors: Wayne Frederick Leech, Fadil Al Alawi, Karthigeyan Nanjan
  • Patent number: 9200003
    Abstract: The present invention relates to novel crystalline modifications of 1-(5?-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3?H-spiro[azetidine-3,1?-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone. The present invention also describes compositions and methods of treating a parasitic infection or infestation in an animal in need thereof. The present invention also relates to processes for making the crystalline forms.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: December 1, 2015
    Assignee: Zoetis Services LLC
    Inventors: Denis Billen, Matthew Joseph Birchmeier, Ronald J. VanderRoest
  • Patent number: 9131697
    Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (1) stereoisomers thereof, veterinary or pharmaceutical acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables W1, W2, W3, W, X, R1a, R1b, R1c, R2, R3, R4, and n are as described herein.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: September 15, 2015
    Assignee: Zoetis Services LLC
    Inventors: Sanjay Menon, Susan M. K. Sheehan, Valerie A. Vaillancourt
  • Patent number: 9125927
    Abstract: Pharmaceutical/dermatological compositions useful for the prevention/treatment of disorders of the skin, especially rosacea, contain thus effective amounts of at least one avermectin compound, e.g., ivermectin, and at least one azelaic acid compound or salt or derivative thereof, formulated into a physiologically acceptable medium therefor.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: September 8, 2015
    Assignee: GALDERMA S.A.
    Inventors: Alexandre Kaoukhov, Colette Pernin
  • Patent number: 9101137
    Abstract: [Problem to be Solved] To provide a pest control composition having an excellent controlling activity on pests. [Solution] A pest control composition comprising pyribencarb and at least one insecticide compound selected from Group (A) has an excellent controlling activity on pests: Group (A): the group consisting of cartap hydrochloride, etofenprox, silafluofen, permethrin, ethiprole, clothianidin, dinotefuran, thiamethoxam and nitenpyram.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: August 11, 2015
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Atsushi Fukuchi, Naomi Tokoro
  • Patent number: 9089586
    Abstract: The present invention relates to levocarrimycin, its pharmaceutical compositions, preparation methods and application. Levocarrimycin is a mixture of isovalerylspiramycin III, II and I as main components and contains some isobutyrylspiramycin III and II, butyrylspiramycin III and II, propionylspiramycin III and II, as well as acetylspiramycin III and II, among which, the content of isovalerylspiramycin III is no less than 30 wt %, the total content of isovalerylspiramycin III, II and I is no less than 60 wt %, and the content of acylspiramycin is 80-98 wt %. Specific optical rotation of said levocarrimycin is [?]D=?52°˜?57° in the solution of 0.02 g/ml chloroform at temperature of 25° C. The present invention also relates to the crystalline compound of isovalerylspiramycin III, II or I in levocarrimycin, and pharmaceutical compositions containing the said levocarrimycin.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: July 28, 2015
    Assignee: SHENYANG TONGLIAN GROUP CO., LTD.
    Inventors: Yang Jiang, Yuyou Hao
  • Patent number: 9056864
    Abstract: Crystalline form of abacavir that is essentially free of solvent of formula (I), in particular crystalline Form I, and its preparation process which comprises the following steps: a) crystallizing abacavir from a solution of said compound in a (C1-C4)-alcohol, dichloromethane, acetonitrile/water, or mixtures thereof; b) isolating the crystalline form of abacavir that appears in the prior step; and c) removing the solvent from the crystalline form of abacavir thus obtained. Crystalline Form I can also be obtained by dispersion of abacavir in acetonitrile. The crystalline form of abacavir that is essentially free of solvent is useful for the preparation of pharmaceutical compositions for use in the treatment and/or prophylaxis of HIV infections.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: June 16, 2015
    Assignee: ESTEVE QUIMICA, S.A.
    Inventors: Marti Bartra Sanmartí, Ramón Berenguer Maimó, Jordi Benet-Buchholz, Lluis Solà I Carandell
  • Publication number: 20150111731
    Abstract: A pesticidal composition comprises one or more of the following compounds: 3-(thiazol-2-yl)pyridine 1-oxide compound of formula I or II, or N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-3-(methylthio)propanamide compound (C3), or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Negar Garizi, Martin J. Walsh, Ann M. Buysse, Daniel Knueppel, Asako Kubota, Noormohamed M. Niyaz, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Publication number: 20150111745
    Abstract: A pesticidal composition comprises a synergistically effective amount of a chloride channel activator compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-((3,3,3 -trifluoropropyl)thio) propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-((3,3,3,3-trifluoropropyl) sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by pests comprises contacting the plant with the synergistic pesticidal composition.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak, John Herbert
  • Publication number: 20150111733
    Abstract: A pesticidal composition comprises at least one compound selected from a 1-(3-pyridyl-N-oxide)pyrazole compound of formula I, II, or III, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R12, R13, Y, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Martin J. Walsh, Daniel Knueppel, Noormohamed M. Niyaz, Ann M. Buysse, Negar Garizi, Asako Kubota, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Publication number: 20150111732
    Abstract: A pesticidal composition comprises a 3-(1H-pyrazol)pyridine compound of formula I or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R9, R10, R12, x, n, and Q are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Martin J. Walsh, Ann M. Buysse, Asako Kubota, Noormohamed M. Niyaz, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Publication number: 20150111734
    Abstract: A pesticidal composition comprises at least one compounds selected from a compound of formula, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, Q, Z, L, La, and x are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Inventors: Yu Zhang, Asako Kubota, Noormohamed M. Niyaz, Thomas Barton, Tony K. Trullinger, Christian T. Lowe, Paul R. LePlae, Ann M. Buysse, Martin J. Walsh, Negar Garizi, Ricky Hunter, Daniel Knueppel
  • Patent number: 9012361
    Abstract: The present invention provides: a composition for controlling pests comprising, as active ingredients, ethaboxam and avermectin; a method for controlling pests which comprises applying effective amounts of ethaboxam and avermectin to a pest, a plant or soil for growing plant; and so on.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: April 21, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Makoto Kurahashi
  • Publication number: 20150105340
    Abstract: An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a shampoo-condition which comprises an effective amount of avermectin, solubilizers, suspending agents, preservatives, nonionic surfactants, humectants, a silicone compound, and water. Also disclosed are methods of using the topical formulations disclosed within this specification to treat either a susceptible or treatment-resistant strain of lice, as well as uses in the manufacture of a medicament for treating or preventing a lice infestation from a susceptible or treatment-resistant strain in a human patient.
    Type: Application
    Filed: December 16, 2014
    Publication date: April 16, 2015
    Inventors: Nicholas Spring, Garry T. Gwozdz
  • Publication number: 20150099628
    Abstract: Insecticidal compositions suitable for use in preparation of insecticidal liquid fertilizers are disclosed, the compositions comprising bifenthrin, at least one other unencapsulated crop protection agent having a melting point of about 50° C. or greater, a hydrated aluminum-magnesium silicate, and at least one dispersant selected from the group consisting of a sucrose ester, a lignosulfonate, an alkylpolyglycoside, a naphthalenesulfonic acid formaldehyde condensate and a phosphate ester.
    Type: Application
    Filed: March 18, 2014
    Publication date: April 9, 2015
    Applicant: FMC Corporation
    Inventor: Timothy M. Martin
  • Publication number: 20150098928
    Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure.
    Type: Application
    Filed: January 6, 2014
    Publication date: April 9, 2015
    Applicant: E.I. du Pont de Nemours and Company
    Inventors: George Philip Lahm, Ty Wagerle, Ming Xu
  • Publication number: 20150087510
    Abstract: Fungicidal mixtures, comprising as active components 1) at least one 1-methylpyrazol-4-ylcarboxanilide of the formula I where R1?C1-C4-alkyl or C1-C4-haloalkyl, R2=hydrogen or halogen, X=hydrogen or halogen, Q=direct bond, a cyclopropylene or an anellated bicyclo[2.2.
    Type: Application
    Filed: September 29, 2014
    Publication date: March 26, 2015
    Inventors: Markus GEWEHR, Ulf GROEGER, Egon HADEN, Michael VONEND
  • Patent number: 8987218
    Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 24, 2015
    Assignee: Galderma S.A.
    Inventors: Alexandre Kaoukhov, Christophe Villard, Philippe Bouissou
  • Patent number: 8974807
    Abstract: The novel active compound combinations of extracts from seeds of the neem tree and the active compounds of groups (B) to (F) listed in the description have very good insecticidal and acaricidal properties.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 10, 2015
    Assignee: Bayer Cropscience AG
    Inventors: Gerhard Baron, Michael Kilian, Frank Rosenfeldt