Fungus (e.g., Athlete's Foot, Ringworm, Etc.) Destroying Or Inhibiting Patents (Class 514/3.3)
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Publication number: 20130230572Abstract: Composite biomaterials are described, which can be implanted in the human body in various branches of surgery or on the skin in dermocosmetic surgery, which can be formed as membranes or felts and which have properties of rate of absorption in the body and of hydrophilicity that can be modulated.Type: ApplicationFiled: November 11, 2011Publication date: September 5, 2013Inventors: Davide Cremascoli, Edgardo Cremascoli
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Publication number: 20130219532Abstract: The present invention relates to antifungal and/or antibacterial peptides, especially antifungal peptides obtained from insect species, particularly lepidopterans. The present invention also provides methods of using these antifungal peptides to treat or prevent fungal growth for a variety of purposes, such as protecting plants from fungal infections; treating fungal infections of animals, especially humans; and prevention of food spoilage.Type: ApplicationFiled: March 27, 2013Publication date: August 22, 2013Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter David East, Susan Elizabeth Brown
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Publication number: 20130202598Abstract: The present invention relates to activatable toxin complexes which include a cleavable inhibitory peptide. More specifically, the complexes comprise a cell targeting domain, a toxin catalytic domain, a specific protease cleavage site and an inhibitory peptide domain. The inhibitory peptide prevents the catalytic domain from exerting toxic effects until its release from the complex by the action of a protease, such a viral protease, at the protease cleavage site. Further provided are pharmaceutical compositions comprising the complexes and use thereof for treating infections and malignant disease.Type: ApplicationFiled: August 22, 2011Publication date: August 8, 2013Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Itai Benhar, Assaf Shapira, Meital Gal-Tanamy, Dana Greenfeld, Limor Nahary, Romy Zemel, Ran Tur-Kaspa
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Publication number: 20130203595Abstract: Embodiments include a colloidal mixture comprising a liquid component and a solid component dispersed in the liquid component. The solid component comprises a plurality of fine-solid (FS) particles, and a plurality of phage particles having binding domains, or binding portions thereof, selected to bind to the plurality of FS particles. Embodiments also include methods or making colloids, method for improving the colloidal stability of a mixture, methods for inhibiting the growth of unwanted organisms, storage and shipping systems, and bio-additives.Type: ApplicationFiled: November 24, 2010Publication date: August 8, 2013Applicant: SYNGENTA CROP PROTECTION LLCInventors: Jeffrey David Fowler, Jason Leigh Vincent
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Publication number: 20130195997Abstract: The invention relates to a method of controlling fungi and spores and to compositions suitable for this purpose and their use. The compositions according to the invention comprise trifloxystrobin, formate and optionally at least one further fungicide.Type: ApplicationFiled: February 1, 2011Publication date: August 1, 2013Applicant: LANXESS DISTRIBUTION GMBHInventors: Frank Saalfeld, Johannes Gareiss
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Patent number: 8470765Abstract: A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).Type: GrantFiled: March 5, 2010Date of Patent: June 25, 2013Assignee: AnGes MG, Inc.Inventors: Takefumi Gemba, Hideki Tomioka, Nao Tamura, Akiko Tenma
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Publication number: 20130150286Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.Type: ApplicationFiled: June 25, 2010Publication date: June 13, 2013Inventors: Jean-Claude Sirard, Jose A. Chabalgoity
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Patent number: 8445636Abstract: The invention provides lipophilic conjugates comprising a peptide coupled to a fatty acid, the peptide comprising at least two positively charged amino acid residues, said peptide after conjugation to the fatty acid possessing antibacterial, antifungal, and/or anticancer activity higher than prior to conjugation. The lipophilic conjugates are suitable for treatment of infections caused by pathogenic organisms such as bacteria and fungi. The lipophilic conjugates are also suitable for sanitation, as disinfectants, or for food preservation.Type: GrantFiled: January 11, 2010Date of Patent: May 21, 2013Assignee: Yeda Research & Development Co. Ltd.Inventors: Yechiel Shai, Dorit Avrahami
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Publication number: 20130122046Abstract: Use of an ubiquitination pathway-related factor, its agonist or antagonist in the preparation of a composition for regulating FOXP3, IL-2, and/or IFN-? activity, in which the ubiquitination pathway-related factor is selected from: Toll-like receptor, ubiquitin ligase, pro-inflammatory cytokine family receptor, and/or its coding sequence. The new type of regulatory factors can regulate regulatory T cells and immune system by regulating FOXP3, IL-2, and/or IFN-? activity. The regulatory factors and their derivatives can also be used as immunoadjuvant for treating or preventing major diseases (such as, infectious diseases and tumor, etc).Type: ApplicationFiled: July 11, 2011Publication date: May 16, 2013Applicant: INSTITUT PASTEUR OF SHANGHAI, CASInventors: Bin Li, Fang Lin, Zuojia Chen, Zhiyuan Li, Fan Pan
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Publication number: 20130108575Abstract: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.Type: ApplicationFiled: October 16, 2012Publication date: May 2, 2013Applicant: C3 JIAN, INC.Inventor: C3 Jian, Inc.
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Publication number: 20130096051Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and re-search use. In particular, the present invention provides antiviral and antimicrobial lectin compounds (BanLec) isolated from bananas. These compounds have low mitogenicity and pro-inflammatory activity whilst maintaining anti-HIV-1 activity.Type: ApplicationFiled: April 11, 2011Publication date: April 18, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
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Patent number: 8404633Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.Type: GrantFiled: June 19, 2009Date of Patent: March 26, 2013Assignees: Hospital Clinic I Provincial de Barcelona, Universitat de Barcelona, Fundacio Clinic per a la Recerca BiomedicaInventors: Francisco Lozano Soto, Jorge Vera Fernandez
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Publication number: 20130071412Abstract: The invention features a powdered composition including a pharmaceutically active compound and a protein or a hydrolyzed protein. In particular, the powdered composition forms a stable solution or dispersion suitable for oral administration in which the protein or the hydrolyzed protein is bound to the pharmaceutically active compound. The invention also provides a method of administering the composition, such as to a patient with dysphasia; liquid or semi-solid formulations of the composition; methods for preparing the composition; and kits including the composition.Type: ApplicationFiled: December 17, 2010Publication date: March 21, 2013Applicant: Exodos Life Sciences Limited PartnershipInventors: Harry J. Leighton, Crist J. Frangakis
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Publication number: 20130064809Abstract: A composition for prophylactic and/or therapeutic medicinal applications, or plant protection applications, in particular for the control of microorganisms, either planktonic or organized in biofilms. The composition includes at least one ion selected from hypohalite, at least one compound selected from lactoferrin, lactoferrin peptide, lysozyme, immunoglobulins or a combination thereof, optionally hypothiocyanite, and optionally at least one growth factor.Type: ApplicationFiled: August 6, 2012Publication date: March 14, 2013Inventor: Jean-Paul PERRAUDIN
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Publication number: 20130029902Abstract: A peptide having the following amino acid sequence: Z1-LVRYTKKVPQVSTPTL-Z2(ALB-408) and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, phosphorylated and/or glycosylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of ALB408-423; wherein Z represents number of from 0 to 10 amino acid residues.Type: ApplicationFiled: July 3, 2008Publication date: January 31, 2013Inventors: Wolf-Georg Forssmann, Frank Kirchhoff, Jan Münch, Ludger Ständker
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Publication number: 20130023461Abstract: The present invention relates to novel agents, pharmaceutical compositions containing them, and their use in therapy, particularly anti-microbial and anti-cancer therapy. In particular, the present invention relates to novel peptide-based compounds based on SEQ ID NO:40 which have surprisingly been shown to have inhibitory effects on the growth and/or viability of cells, particularly bacterial and cancer cells. Also provided are therapeutic and non-therapeutic methods which comprise the use of peptides of the invention.Type: ApplicationFiled: February 1, 2011Publication date: January 24, 2013Inventor: Lars Prestegarden
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Publication number: 20130011398Abstract: This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an Fc polypeptide or an amino acid sequence that is derived from an Fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a WAP domain containing polypeptide or a sequence derived from a WAP containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules.Type: ApplicationFiled: June 28, 2012Publication date: January 10, 2013Applicant: InhibRx LLCInventors: Brendan Eckelman, John Timmer, Peter L. Nguy, Grant B. Guenther, Quinn Deveraux
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Publication number: 20130004564Abstract: The present invention relates to novel peptides having antimicrobial activity, and compositions containing the same.Type: ApplicationFiled: December 13, 2010Publication date: January 3, 2013Applicants: UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Aurélle Tasiemski, Michel Salzet, Françoise Gaill
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Patent number: 8343913Abstract: A method of reducing antifungal drug resistance in which Hsp inhibitors, such as Hsp90 inhibitors, are used.Type: GrantFiled: July 5, 2005Date of Patent: January 1, 2013Assignee: Whitehead Institute for Biomedical ResearchInventors: Leah Cowen, Susan L. Lindquist
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Publication number: 20120328568Abstract: The disclosure relates to uses of a purified or isolated lectin to kill bacteria, viruses, and other pathogens. In certain embodiments, the disclosure relates to method of treating or preventing an infection comprising administering a purified or isolated galectin to a subject in need thereof. In certain embodiments, the subject is at risk of, exhibiting symptoms of, or diagnosed with a pathogenic infection.Type: ApplicationFiled: February 11, 2011Publication date: December 27, 2012Applicant: EMORY UNIVERSITYInventors: Richard D Cummings, Sean R. Stowell, Connie Arthur
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Patent number: 8329191Abstract: The present invention relates to three-branched PEG-G-CSF conjugate of general formula (1) in which the bonding ratio of three-branched polyethylene glycol (PEG) and G-CSF is 1:1 (mol/mol), wherein PEG has an average molecular weight of from 200 to 45,000 daltons; a pharmaceutical composition comprising the same, and a preparing method thereof.Type: GrantFiled: November 22, 2006Date of Patent: December 11, 2012Assignee: Dong-A-Pharm. Co., Ltd.Inventors: Yeong-Woo Jo, Won-Young Yoo, Hyun-Kyu Jeon, Yun-Kyu Choi, Hye-In Jang, Byong-Moon Kim, Sung-Hee Lee, Soo-Hyung Kang, Moo-Hi Yoo
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SYNERGISTIC COMBINATIONS OF POLYENE FUNGICIDES AND NON-RIBOSOMAL PEPTIDES AND RELATED METHODS OF USE
Publication number: 20120302494Abstract: The present invention includes compositions comprising a synergistic fungicidal combination of a polyene fungicide and at least one lipopeptide and methods for using such compositions in controlling fungal pathogens.Type: ApplicationFiled: May 23, 2012Publication date: November 29, 2012Inventors: Magalie GUILHABERT-GOYA, Jonathan S. MARGOLIS -
Publication number: 20120295837Abstract: A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking therebetween, such as an omega-amino-fatty acid residue, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.Type: ApplicationFiled: December 8, 2011Publication date: November 22, 2012Applicant: Technion Research & Development Foundation Ltd.Inventors: Amram MOR, Inna RADZISHEVSKY
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Publication number: 20120295840Abstract: A method for treating a human infected with Aspergillus by using thymosin alpha 1 as an immuno-stimulator in activating dendritic cells. The method is particularly useful in preventing an infection by Aspergillus in an immuno-compromised host being treated with a bone marrow transplantation.Type: ApplicationFiled: May 29, 2012Publication date: November 22, 2012Applicant: SCICLONE PHARMACEUTICALS, INC.Inventors: Guido RASI, Enrico GARACI, Francesco BISTONI, Luigina ROMANI, Paolo Di Francesco
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Publication number: 20120269772Abstract: The present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.Type: ApplicationFiled: June 29, 2012Publication date: October 25, 2012Applicant: Camurus ABInventors: Krister THURESSON, Fredrik TIBERG, Markus JOHANSSON, Ian HARWIGSSON, Fredrik JOABSSON, Markus JOHNSSON
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Publication number: 20120258907Abstract: The present invention relates to the use of a polypeptides, comprising repeats of a peptide derived from a Heparan Sulphate Proteoglycan (HSPG) receptor binding region of an apolipoprotein, for treating or preventing a fungal and/or protist infection. The invention further relates to the use of such peptides for treating or preventing the contamination of surfaces or objects with such peptides.Type: ApplicationFiled: December 22, 2011Publication date: October 11, 2012Applicant: AI2 LIMITEDInventor: Curtis Dobson
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Publication number: 20120251444Abstract: The present invention relates to the use of receptor-associate protein (RAP) and fragments and variants thereof to improve delivery of therapeutic compounds to the liver and provides methods to treat liver disorders and conditions, such as hepatic carcinoma, by administering RAP or RAP variants conjugated to active agents.Type: ApplicationFiled: September 18, 2007Publication date: October 4, 2012Inventors: Christopher M. Starr, Todd C. Zankel
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Patent number: 8257478Abstract: Compounds originally isolated from marine fungi are useful as antifouling (antibacterial and/or anti-larval settlement) agents. The compounds are 3-chloro-2,5-dihydroxy benzyl alcohol, cyclo-(Pro-Phe),3-methyl-N-(2-phenylethyl) butanamide, and succinic acid. The compounds are non-toxic or low-toxic. They can be used alone or in combination, as active ingredients for making environment-friendly antifouling formulations/coatings.Type: GrantFiled: December 16, 2005Date of Patent: September 4, 2012Assignee: The Hong Kong University of Science and TechnologyInventors: Pei-Yuan Qian, Xiancui Li, Fuk Ning Kwong, Lai Hung Yang, Sergey Vladimirovich Dobretsov
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Publication number: 20120202736Abstract: The present invention relates to a spray-dried composition comprising as an active ingredient at least one member protein of the collectin family or its functional equivalent for treating and preventing microbial infectious diseases. The present invention also relates to a method for producing the same composition. The composition produced by the method of the present invention is effective in suppressing infections caused by viruses, bacteria, fungi, and parasites. Since the composition is developed in a form suitable for inhalation, it can directly provide the active ingredient to the sites of infection from these microbes, and thus treat and prevent respiratory infections and external wounds.Type: ApplicationFiled: April 18, 2012Publication date: August 9, 2012Applicant: DOBEEL CORPORATIONInventors: Hong Mo MOON, Jung Sun YUM, Byung Cheol AHN, Joo Youn LEE
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Publication number: 20120189682Abstract: The present invention relates to a product comprising at least two antibiofilm agents wherein at least one of the antibiofilm agents is an antimicrobial peptide. The second antibiofilm agent is generally a dispersant or an anti-adhesive agent. There is also provided the use of the product in the treatment of a microbial infection.Type: ApplicationFiled: March 31, 2010Publication date: July 26, 2012Applicant: Novabiotics LimitedInventors: Deborah O'Neil, Derry Mercer, Cedric Charrier
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Patent number: 8227406Abstract: The invention relates to an antimicrobial peptide comprising a first set of amino acid residues having a length of from about 2 to about 36 amino acid residues or analogues thereof linked to the amino or carboxyterminal end a second set comprising from 3 to 8 hydrophobic amino acid residue or analogue thereof, wherein said peptide has an antimicrobial activity.Type: GrantFiled: May 15, 2007Date of Patent: July 24, 2012Assignee: Dermagen ABInventors: Artur Schmidtchen, Martin Malmsten
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Publication number: 20120172287Abstract: A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a burns, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.Type: ApplicationFiled: May 25, 2010Publication date: July 5, 2012Applicant: ANGES MG, Inc.Inventors: Takefumi Gemba, Hideki Tomioka, Nao Tamura, Ryoko Sata, Akito Maeda, Akiko Tenma, Toshihide Kanamori, Yoshimi Saito, Shintaro Komaba, Ryuichi Morishita
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Publication number: 20120165247Abstract: A method of using a beef extract or a protein hydrolisate or a mixture of beef extract and protein hydrolisate, as active substance, for treatment and/or prophylaxis of plants against the action of pathogens is described. A composition including a beef extract or a protein hydrolisate or a mixture of beef extract and protein hydrolisate, as active substance, for treatment and/or prophylaxis of plants against the action of pathogens is also described.Type: ApplicationFiled: August 5, 2010Publication date: June 28, 2012Inventors: Ilaria Pertot, Yigal Elad
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Publication number: 20120114742Abstract: Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.Type: ApplicationFiled: January 13, 2012Publication date: May 10, 2012Applicant: Mountain View Pharmaceuticals, Inc.Inventors: Alexa L. MARTINEZ, Merry R. Sherman, Mark G.P. Saifer, L. David Williams
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Publication number: 20120101026Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation.Type: ApplicationFiled: December 30, 2011Publication date: April 26, 2012Applicant: ONYX THERAPEUTICS, INC.Inventors: Mark S. Smyth, Guy J. Laidig, Ronald T. Borchardt, Barry A. Bunin, Craig M. Crews, John H. Musser, Kevin D. Shenk, Peggy A. Radel
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Publication number: 20120093836Abstract: The present invention relates to the use of an antifungal agent or of a compound capable of binding to a mannoprotein and blocking the binding of said mannoprotein to an endothelial cell receptor, in the preparation of a pharmaceutical composition for treating a disease associated to an unwanted cell adhesion. Likewise, the present invention also contemplates methods aimed at identifying a compound potentially useful for preventing and/or treating a disease associated to an unwanted cell adhesion, for predicting the probability of a patient suffering from cancer to suffer from metastasis and for designing a personalized therapy for a patient suffering from cancer.Type: ApplicationFiled: March 30, 2010Publication date: April 19, 2012Applicant: UNIVERSIDAD DEL PAIS VASCOInventors: Fernando Hernando Echevarría, Andoni Ramírez García, Fernando Vidal-Vanaclocha, Lorea Mendoza Arteche, Natalia Gallot Escobal
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Publication number: 20120088717Abstract: The present invention is directed to a method of treating a fungal infection with a fusion peptide that includes a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia. The fungal targeting agent can be a pheromone, such as an alpha-mating pheromone. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.Type: ApplicationFiled: March 15, 2011Publication date: April 12, 2012Applicant: PHEROMONICIN BIOTECH, LTD.Inventor: Xiao-Qing Qiu
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Publication number: 20120066793Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:13-24 or the nucleotide sequence set forth in SEQ ID NO:1-12 and 25-44, as well as variants and fragments thereof.Type: ApplicationFiled: November 21, 2011Publication date: March 15, 2012Applicant: Athenix CorpInventors: Kimberly S. Sampson, Daniel John Tomso
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Publication number: 20120065126Abstract: The invention relates to a pharmaceutical composition containing, in a pharmaceutical carrier, a peptide comprising at least one sequence motif of the following general formula (I) Hel1-HB-Hel2. The invention also relates to the use and production of said pharmaceutical compositions.Type: ApplicationFiled: May 12, 2010Publication date: March 15, 2012Applicant: BASF SEInventors: Heike Brüser, Daniel Hümmerich, Claus Bollschweiler, Carsten Schwalb
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Publication number: 20120058935Abstract: The invention features antimicrobial compositions comprising ?-amyloid peptides, oligomers, and analogs thereof, and methods of using them for the prevention or treatment of an infection.Type: ApplicationFiled: March 12, 2010Publication date: March 8, 2012Applicant: The General Hospital CorporationInventors: Robert Moir, Rudolph E. Tanzi
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Publication number: 20120054910Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for family members of a novel family of antipathogenic polypeptides. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polnucleotide or polypeptide of the invention are also disclosed.Type: ApplicationFiled: August 9, 2011Publication date: March 1, 2012Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Daniel J. Altier, Jacob T. Gilliam, Eric J. Schepers, Nasser Yalpani
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Publication number: 20120052104Abstract: A novel polypeptide, and an antibacterial agent, antifungal agent and/or antiseptic containing as an effective ingredient the polypeptide are disclosed. The polypeptide of this invention has an amino acid sequence shown in SEQ ID NOs:1 to 12 and 13 to 31. This antibacterial agent, antifungal agent and/or antiseptic is useful for the prevention, amelioration or treatment of diseases such as burn, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliterans, cellulitis, acute lymphangitis, lymphadenitis, erysipelas, skin abscess, necrotizing subcutaneous infection, staphylococcal scalded skin syndrome (SSSS), folliculitis, facial furuncle, suppurative hidradenitis, carbuncle, infectious paronychia, erythrasma and severe infection (sepsis).Type: ApplicationFiled: March 5, 2010Publication date: March 1, 2012Applicant: ANGES MG, Inc.Inventors: Takefumi Gemba, Hideki Tomioka, Nao Tamura, Akiko Tenma
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Publication number: 20120054911Abstract: Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include amino acid sequences, and variants and fragments thereof, for novel variants of antipathogenic polypeptides generated through DNA shuffling that exhibit improved antipathogenic activity. Polynucleotides that encode the antipathogenic polypeptides are also provided. A method for inducing pathogen resistance in a plant using the polynucleotides disclosed herein is further provided. Compositions comprising an antipathogenic polypeptide or a microorganism comprising an antipathogenic polynucleotide of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Plants, plant cells, seeds, and microorganisms comprising an antipathogenic polynucleotide or polypeptide of the invention are also disclosed.Type: ApplicationFiled: August 19, 2011Publication date: March 1, 2012Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: James J. English, Susan L. Grant, Jeffrey S. Pollack, Julia L. Ritland, Gary A. Sandahl
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Publication number: 20120040033Abstract: The current invention discloses drug formulations of anti-infective mangrove extracts and their ability to block the reproductive capabilities of viruses, funguses, bacteria and tumors. Mangrove extracts can be ingested internally to prevent the proliferation of viruses, funguses, bacteria and tumors in humans and other animals; or the mangrove extracts can be applied directly to the skin, in the form of a disinfectant hand gel, to fight microbial infection.Type: ApplicationFiled: August 10, 2011Publication date: February 16, 2012Inventor: Ernest Timothy Armstrong
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Publication number: 20120028886Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compostions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: September 15, 2011Publication date: February 2, 2012Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Publication number: 20120028885Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compositions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: September 15, 2011Publication date: February 2, 2012Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Publication number: 20120028884Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compostions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: September 14, 2011Publication date: February 2, 2012Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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GROWTH ENHANCEMENT AND CONTROL OF BACTERIAL AND FUNGAL PLANT DISEASES WITH STREPTOMYCES SCOPULIRIDIS
Publication number: 20120028799Abstract: Methods of controlling plant diseases mediated by bacterial or fungal plant pathogens. The method comprises providing Streptomyces scopuliridis strain RB72 or an isolated protein or polypeptide comprising the amino acid of SEQ ID NO:1 and applying the Streptomyces scopuliridis strain RB72 or the isolated protein or polypeptide comprising the amino acid of SEQ ID NO:1 to plants or plant seeds under conditions effective to treat plant diseases mediated by bacterial or fungal plant pathogens. Also disclosed is a plant or plant seed treated by this method, a planting composition, and a method of enhancing growth.Type: ApplicationFiled: July 29, 2011Publication date: February 2, 2012Applicant: BIOWORKS, INC.Inventors: William R. MARTIN, JR., Nicole J. SCOTT -
Publication number: 20120021975Abstract: The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus.Type: ApplicationFiled: January 29, 2010Publication date: January 26, 2012Inventors: Ralf Hoffmann, Daniel Knappe, Anna Klara Brigitte Hansen
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Publication number: 20120015872Abstract: Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.Type: ApplicationFiled: June 16, 2011Publication date: January 19, 2012Applicants: The Regents of the University of Colorado, MUSC Foundation for Research DevelopmentInventors: Stephen TOMLINSON, V. Michael Holers