Fungus (e.g., Athlete's Foot, Ringworm, Etc.) Destroying Or Inhibiting Patents (Class 514/3.3)
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Publication number: 20120015871Abstract: Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.Type: ApplicationFiled: June 16, 2011Publication date: January 19, 2012Applicants: The Regents of the University of of Colorado, MUSC Foundation for Research DevelopmentInventors: Stephen TOMLINSON, V. Michael Holers
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Publication number: 20120014952Abstract: Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.Type: ApplicationFiled: June 16, 2011Publication date: January 19, 2012Applicants: The Regents of the University of Colorado, MUSC Foundation for Research DevelopmentInventors: Stephen Tomlinson, V. Michael Holers
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Publication number: 20120010129Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compostions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: July 20, 2011Publication date: January 12, 2012Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Publication number: 20120010128Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compostions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: July 20, 2011Publication date: January 12, 2012Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Publication number: 20120005790Abstract: The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.Type: ApplicationFiled: March 18, 2010Publication date: January 5, 2012Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENTInventors: Ali Ladram, Denis Sereno, Feten Abassi, Bruno Oury, Mohamed Amiche, Pierre Nicolas
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Publication number: 20110319320Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compostions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: June 30, 2011Publication date: December 29, 2011Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Publication number: 20110312877Abstract: Biomedical nanoparticles are disclosed based on new engineered modular carrier macromolecules, on engineered macromolecules or associated entities providing an internal nanoparticle structure, and compositions for minimizing non-specific binding of the nanoparticles while enabling efficient and convenient targeting to cells and tissues. These nanoparticles may be used to deliver atomic or molecular or associated entities which are useful for diagnostics, primarily in vivo imaging, for therapeutics, for vaccines, or for experimental research. Nanoparticles comprising combinations of active entities such as gene inhibitors with gene expression cassettes or imaging agents with therapeutic agents, and polyamide compounds useful for treatment of microbial infections are also disclosed.Type: ApplicationFiled: February 26, 2009Publication date: December 22, 2011Applicant: APARNA BIOSCEIENCESInventors: Mark Berninger, Puthupparampil Scaria, Martin Woodle
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Patent number: 8080256Abstract: The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.Type: GrantFiled: November 6, 2008Date of Patent: December 20, 2011Assignee: Regents of the University of CaliforniaInventors: Gary A. Strobel, Yuhao Ren, David B. Teplow
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Patent number: 8071540Abstract: Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the Lytic Base Unit (LBU) peptides, derived from the LLP1 analogs and also having antimicrobial activity. Also described herein are using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. Methods of killing fungi, such as Candida and Cryptococcus species, and bacteria, such as B. anthracis, are provided herein. Methods of neutralizing enveloped viruses, such as poxvirus, herpesvirus, rhabdovirus, hepadnavirus, baculovirus, orthomyxovirus, paramyxovirus, retrovirus, togavirus, bunyavirus and flavivirus, including influenza virus and HIV-1 also are provided herein. Solid phase substrates and peptide-cargo complexes comprising the peptides also are provided.Type: GrantFiled: July 11, 2008Date of Patent: December 6, 2011Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Ronald C. Montelaro, Timothy A. Mietzner
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Publication number: 20110294724Abstract: Disclosed is an antimicrobial peptide having an amino acid sequence of formula presented as (P1)M(nA1X1X2)N(P2)X, wherein P1 is selected from the group consisting of basic amino acids including Arg and Lys; A1 is selected from the group consisting of aromatic amino acids including Trp, Phe and Ala; X1 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; X2 is selected from the group consisting of basic amino acids or nonpolar amino acids, including Arg, Lys, Val, Leu, Ala and Ile; P2 is selected from the group consisting of basic amino acids including Arg and Lys; and the numbers of M and X are respectively 0˜2; when N>2, A1 is Ala and the Ala residues are less than N?2.Type: ApplicationFiled: March 29, 2011Publication date: December 1, 2011Inventors: Jya-Wei CHENG, Kuo-Chun HUANG, His-Tsu CHENG, Hui-Yuan YU
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Publication number: 20110288007Abstract: The present invention relates to a biocidal fusion peptide comprising: a) a peptide LL-37 or an active fragment or active derivative thereof; b) and a further heterologous bioactive peptide or an active fragment thereof, wherein part or all of the amino acid sequence of the fusion peptide is predicted to form an alpha-helix structure for disruption of a pathogen membrane, compositions such as pharmaceutical compositions comprising the same, methods of preparing the peptide and use of the peptides in treatment, in particular for the treatment of bacterial infection and/or fungal infection and/or viral infection.Type: ApplicationFiled: November 30, 2009Publication date: November 24, 2011Applicant: THE SECREATARY OF STATE FOR DEFENCEInventors: Marc Alan Fox, Joanne Elizabeth Thwaite, Timothy Philip Atkins, David Okhono Ulaeto
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Publication number: 20110280920Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY (SEQ ID NO: 1), YDYNLY (SEQ ID NO: 2), FDYNFY (SEQ ID NO: FDYNLY (SEQ ID NO: 4), FDYNWY (SEQ ID NO: 5), YDWNLY (SEQ ID NO: 6), YDWHLY (SEQ ID NO: 7) and WDYNLY (SEQ ID NO: 8), extracted from organisms such as aquatic organisms and mossor any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.Type: ApplicationFiled: September 23, 2009Publication date: November 17, 2011Inventors: Amir Zlotkin, Hen Kestenboim
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Publication number: 20110269673Abstract: The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n ??(I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.Type: ApplicationFiled: June 28, 2011Publication date: November 3, 2011Applicant: NOVABIOTICS LIMITEDInventor: Deborah O'Neil
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Publication number: 20110269672Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compositions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: June 30, 2011Publication date: November 3, 2011Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Patent number: 8048852Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilizing microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.Type: GrantFiled: April 20, 2007Date of Patent: November 1, 2011Assignee: Lytix Biopharma ASInventors: John Sigurd Svendsen, Bengt Erik Haug, Istvan Marko, Øystein Rekdal, Merete Linchausen Skar, Wenche Stensen, Morten Bøhmer Strøm
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Patent number: 8048853Abstract: The present invention relates to novel intermediates of formula VII, or an acid addition salt or a solvate thereof, wherein R1 is —(CO)NH2, —CH2NH2 or —CN; R2=R3=H or R2 and R3 together form a cyclic boronate or borate ester; X is a helping group selected from the group consisting of i) a five or six membered heterocyclic aromatic ring and derivatives thereof comprising at least one N-atom being a part of an imine-group, wherein said N-atom forms the point of connection to the cyclohexapeptide ring, and ii) tetrazolyl and derivatives thereof for which a nitrogen atom forms the point of connection to the cyclohexapeptide ring, and a process for the preparation of caspofungin utilizing said intermediates.Type: GrantFiled: June 13, 2008Date of Patent: November 1, 2011Assignee: Xellia Pharmaceuticals APSInventors: Audun Heggelund, Ole Heine Kvernenes, Vidar Bjørnstad
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Publication number: 20110256213Abstract: The invention generally relates to compositions and methods for the reduction or neutralization of toxins associated with a bacterial, mycobacterial, fungal, viral, or protozoal agent. More particularly, the invention is directed to sterically stabilized phospholipid micellar and liposomal compositions, which interact with the toxins to decrease or neutralize their toxicity. Additionally, the invention includes the use of sterically stabilized phospholipid micellar compositions comprising one or more water-insoluble antibiotic, antifungal, antiviral, antiprotozoal, or anti-inflammatory agent(s), wherein the micellar or liposomal composition inhibits the formation of aggregates. The invention further includes the use of sterically stabilized micelle and liposomal compositions to deliver compounds to the site of action, and in some cases targets the compound to the site of action, for the treatment of inflammation and infection.Type: ApplicationFiled: October 15, 2009Publication date: October 20, 2011Applicant: The Board of Trustees of the University of IllinoisInventors: Hayat Onyuksel, Israel Rubinstein
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Patent number: 8026207Abstract: It is intended to provide a novel peptide which can exert higher antifungal effect also on a patient whose organ function is impaired with no side effect problems. The peptide comprises the following amino acid sequence: (1) SEQ ID NO:1: Lys -Arg-Leu-Phe-Arg-Arg-Trp-Gln-Trp-Arg-Tyr, (2) SEQ ID NO:2: Arg-Arg-Trp-Gln -Trp-Arg-Met-Lys-Lys-Tyr, (3) SEQ ID NO:3: Lys-Arg-Trp-Gln-TTp-Arg-Leu-Tyr, or (4) SEQ ID NO:4: Lys-Arg-Leu-Phe-Lys-Tyr, an antifungal agent comprising the peptide, a composition having a fungicidal and/or growth inhibitory action against fungus containing an effective amount of the peptide as an active ingredient, a medical apparatus/device which contains the peptide, whereby a fungicidal action is conferred, and a fungicidal and/or growth inhibiting method against fungus comprising administering the peptide and the like.Type: GrantFiled: September 6, 2006Date of Patent: September 27, 2011Assignees: Japan Science and Technology Agency, Hiroshima University, Two Cells Co., Ltd.Inventors: Hiroki Nikawa, Masahiro Nishimura, Koichiro Tsuiji, Ryoko Kawabata, Nobue Hiromoto
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Publication number: 20110230396Abstract: A medicament to prevent or cure fungal infections of the skin or body openings in an immunologically compromised person or animal can comprise Cystatin S, Cystatin SA, Cystatin SN, or similar agents.Type: ApplicationFiled: August 20, 2009Publication date: September 22, 2011Applicant: ITH Immune Therapy Holdings ABInventor: Ola Winqvist
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Publication number: 20110223202Abstract: The invention discloses an amphiphilic antimicrobial substance comprising a hydrophobic portion coupled to a cationic oligopeptide portion. The cationic oligopeptide portion may comprise a protein transduction domain coupled to a cationic oligopeptide group.Type: ApplicationFiled: December 18, 2008Publication date: September 15, 2011Inventors: Yi-Yan Yang, Lihong Liu
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Publication number: 20110224131Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compostions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: ApplicationFiled: April 19, 2011Publication date: September 15, 2011Applicant: REACTIVE SURFACES, LTD. LLPInventor: C. Steven McDaniel
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Patent number: 8017572Abstract: Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.Type: GrantFiled: October 6, 2008Date of Patent: September 13, 2011Assignee: PoscoInventors: Sung-Ho Ryu, Pann-Ghill Suh, Yoe-Sik Bae, Ji-Young Song
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Publication number: 20110217375Abstract: Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.Type: ApplicationFiled: March 4, 2011Publication date: September 8, 2011Inventors: Neville Robert Kallenbach, Anne W. Young, Zhigang Liu, Chunhui Zhou
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Publication number: 20110195894Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.Type: ApplicationFiled: June 19, 2009Publication date: August 11, 2011Applicants: HOSPITAL CLINIC I PROVINCIAL DE BARCELONA, FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA, UNIVERSITAT DE BARCELONAInventors: Francisco Lozano Soto, Jorge Vera Fernandez
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Publication number: 20110183891Abstract: The present invention describes a previously unknown interaction between secreted aspartic proteases (SAPs), including SAPs 4-6 of Candida albicans, and integrins on host cells. The SAPs secure entry into the host cell through RGD-like binding motifs and subsequently induce apoptosis, thereby clearing the way for systemic infection. The invention thus provide a new target for therapeutic intervention and describes peptides and antibodies that inhibit the action of SAPs in this context, including their interaction with integrins.Type: ApplicationFiled: December 14, 2010Publication date: July 28, 2011Inventors: Jordan Tang, Hao Wu
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Publication number: 20110172145Abstract: The present invention relates to a compound of formula (I) AA-AA-AA-X—Y—Z wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms; X is a N atom, which may be substituted by a branched or unbranched C1-C10 alkyl or aryl group which group may incorporate up to 2 heteroatoms selected from N, O and S; Y represents a group selected from —Ra—Rb—, —Ra—Rb—Rb— and —Rb—Rb—Ra— wherein Ra is C, O, S or N, and Rb is C; each of Ra and Rb may be substituted by C1-C4 alkyl groups or unsubstituted; and Z is a group comprising 1 to 3 cyclic groups each of 5 or 6 non-hydrogen atoms, 2 or more of the cyclic groups may be fused and one or more of the cyclic groups may be substituted; the Z moiety incorporates a maximum of 15 non-hydrogen atoms; and wherein the bond between Y and Z is a covalent bond between Ra or Rb of Y and a non-hydrogen atom of one of the cyclic groups of Z.Type: ApplicationFiled: December 22, 2008Publication date: July 14, 2011Applicant: Lytix Biopharma ASInventors: Wenche Stensen, Erick Bengt Haug, Oystein Rekdal, John Sigurd Svendsen
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Publication number: 20110152175Abstract: The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiety, wherein at least one hydrogen atom of at least one amino group is optionally replaced by a protective group, and a hyperbranched core compound of the formula 3, wherein T and R2 are as defined above. The invention provides also a process for the preparation of a dendrimeric compound and a hyperbranched core, wherein the process employs addition reactions of alkyl acrylate and a basic amino acid, and use of a hyperbranched core for the preparation of a dendrimeric compound comprising amino acids. The invention provides also use of dendrimeric compounds for the preparation of the medicament for inhibiting growth of bacterial cells, fungi and tumor cells.Type: ApplicationFiled: September 18, 2009Publication date: June 23, 2011Applicant: Instytut Chemii Organicznej Polska Akademia NaukInventors: Zofia Lipkowska, Piotr Polcyn, Andrzej Wojciech Lipkowski
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Publication number: 20110144004Abstract: The present invention provides a protein having an A chain of a ricin-like toxin, a B chain of a ricin-like toxin and a heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a disease specific protease such as a cancer, fungal, viral or parasitic protease. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying mammalian cancer cells, cells infected with a virus, a fungus, or parasite, or parasites utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human cancer, viral infection, fungal infection, or parasitic infection.Type: ApplicationFiled: April 29, 2008Publication date: June 16, 2011Applicant: TWINSTRAND THERAPEUTICS INC.Inventor: THOR BORGFORD
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Publication number: 20110135788Abstract: Polydimethylsiloxane and/or siloxane (silicone)-derived chemical compounds are used to coating harvested forages to protect against rain and/or other weather damage and to suppress mold and spoilage in harvested forages. The PDMS compound and derivatives thereof are also found to suppress the damage resulting from oxidation within the feedstuff mass. When applied, PDMS coats the feedstuff and is included in the moisture portion of the feed or forage mass. This helps preserve the feed quality and slows the damaging effects of spoilage organisms and oxidation.Type: ApplicationFiled: May 28, 2010Publication date: June 9, 2011Inventor: MARK L. FOLKMAN
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Publication number: 20110105383Abstract: Embodiments of the invention are directed to methods of treating, inhibiting or attenuating a microbial infection in an individual who has or is at risk for developing such an infection, comprising the step of administering an effective amount of a StIR polypeptide or peptide or fragment or derivative or analog thereof to the individual.Type: ApplicationFiled: September 10, 2009Publication date: May 5, 2011Inventors: Magnus Hook, Dekai Zhang, Christi Gendron, Burton Dickey, Michael Tuvim, Scott Evans
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Publication number: 20110088128Abstract: This invention is related to a protein from the seeds, cotyledons or plantlets of Lupinus genus, as well as to the way of producing the protein in recombinant form and of expressing the protein in genetically modified plants. The invention relates to methods of its use, or of any modification of the protein that maintains its biological properties, as a supplement in human or animal nutrition and as a fungicide, insecticide, growth promoter, fertilizer or in the preparation of genetically modified organisms.Type: ApplicationFiled: September 29, 2010Publication date: April 14, 2011Applicant: INSTITUTO SUPERIOR DE AGRONOMIAInventors: RICARDO MANUEL DE SEIXAS BOAVIDA FERREIRA, SARA ALEXANDRA VALADAS DA SILVA MONTEIRO, ARTUR RICARDO NASCIMENTO TEIXEIRA, VIRGILIO BORGES LOUREIRO
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Publication number: 20110086035Abstract: A peptide of less than 10 000 molecular weight comprising the amino acid sequence FHTYTI DWTKDAVTW or a portion thereof, or a variant thereof wherein the side chains of one or two of the amino acid residues are altered, wherein the portion or variant is capable of binding HLA-DRB1*04. The peptide, certain polypeptide fusion molecules and certain polynucleotides encoding the same may be useful in combating Aspergillus infection or allergies. In particular, they may be used in processes for preparing Aspergillus-specific T cells for adoptive immunotherapy.Type: ApplicationFiled: March 11, 2009Publication date: April 14, 2011Applicant: CELL MEDICA LIMITEDInventor: Max Stanley Topp
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Publication number: 20110077193Abstract: The present invention discloses certain derivatives of artemisinin and the active principles contained in Artemisia annua extracts with amino acids, peptides, and amino sugars, and isomers and salts thereof (formula I).Type: ApplicationFiled: December 1, 2010Publication date: March 31, 2011Applicant: BIODERM RESEARCHInventor: Shyam K. Gupta
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Publication number: 20110071072Abstract: Antifungal bone cement compositions and methods of using the same are disclosed. In one aspect, a bone cement composition comprises an echinocandin lipopeptide antifungal agent and a cementing agent. Optionally, the echinocandin lipopeptide antifungal agent is selected from the group consisting of micafungin, caspofungin and anidulafungin. The echinocandin lipopeptide antifungal agent is optionally micafungin. Methods of preventing a fungal infection following an arthroplasty procedure are also provided.Type: ApplicationFiled: August 26, 2010Publication date: March 24, 2011Applicant: Georgetown University, A Congressionally Chartered Institution of Higher EducationInventors: Richard A. Calderone, Michael O'Reilly
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Publication number: 20110039763Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: January 6, 2010Publication date: February 17, 2011Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20110039761Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: January 6, 2010Publication date: February 17, 2011Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20110039762Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: January 6, 2010Publication date: February 17, 2011Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20110028386Abstract: Disclosed are antimicrobial peptides with useful or superior properties such as antimicrobial activity, desirable levels of hemolysis, and advantageous therapeutic index against various microorganisms, especially Pseudomonas aeruginosa, Acinetobacter baumannii and Staphylococcus aureus. Also provided are methods of to control microbial growth and pharmaceutical compositions to treat or prevent microbial infections. Certain peptides are disclosed utilizing a structure-based rational modification of antimicrobial peptide D1, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face, or peptides with one or more amino acids in the D configuration, and peptides with all amino acids in the D configuration. Modified peptide analogs herein can demonstrate one or more properties such as improved antimicrobial activity, specificity, and resistance to degradation.Type: ApplicationFiled: June 3, 2010Publication date: February 3, 2011Inventors: ROBERT S. HODGES, ZIQING JIANG
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Publication number: 20110028385Abstract: A compound comprising combination of an immunomodulator and to at least one anti-pathogenic agent for treating of facultative or strict infections caused by intracellular microorganisms, the components of the combination or association of substances of the invention, the immunomodulator (proteic aggregate of ammonium and magnesium phospholinoleate-palmitoleate anhydride) and at least one substance with antimicrobial properties can be administered either jointly, simultaneously, consecutively or sequentially, in an appropriate form, according to their chemical properties, and in a dose effective against microorganisms in human and animals.Type: ApplicationFiled: January 27, 2009Publication date: February 3, 2011Inventor: Iseu da Silva Nunes
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Publication number: 20110021415Abstract: The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n??(I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.Type: ApplicationFiled: September 29, 2010Publication date: January 27, 2011Applicant: NOVABIOTICS LIMITEDInventor: DEBORAH O'NEIL
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Publication number: 20110020216Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active recruitment, sequestration, and removal or elimination of undesirable cells from their host.Type: ApplicationFiled: June 11, 2008Publication date: January 27, 2011Inventors: David James Mooney, Omar abdel-Rahman Ali
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Publication number: 20110015120Abstract: Pharmaceutical and cosmetic compositions for topical use comprising Lactoferrin, Ciclopirox and/or salts thereof, Etidronic Acid and/or salts thereof and use of said compositions in the treatment of dermatological disorders and conditions such as seborrheic dermatitis and dandruff.Type: ApplicationFiled: June 17, 2010Publication date: January 20, 2011Applicant: VALETUDO S . r . l .Inventor: Vittorino Bortolin
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Publication number: 20110002983Abstract: The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (II), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R2 is a hydroxyl, a hydrocarbyl, a lipid moiety, a lipid acyl moiety; or an amino hydrocarbyl group optionally substituted with a hydrocarbyl, a lipid moiety or a lipid acyl moiety; R3 and R8 are each independently selected from acetyl, a hydrocarbyl, a lipid moiety and a lipid acyl moiety; X is a peptide chain; The above normuramylglycopeptide compounds can be located in liposomes and micelles and can function as immunomodulators, along with a desired antigen (or DNA encloding the antigen), in (e.g. DNA) vaccines.Type: ApplicationFiled: March 17, 2009Publication date: January 6, 2011Inventors: Karsten Hipler, Andrew Miller, Jaroslav Turanek, Miroslav Ledvina
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Publication number: 20110002994Abstract: It is disclosed a method of immunomodulating an immune response in a subject comprising administering to a subject a malleable protein matrix (MPM), from fermented whey, in an amount effective to modulate the biological activity of Th17 cells, and its associated metabolic pathway, for a preventative or a therapeutic purpose of a variety of health applications in the field of immunity or obesity related diseases.Type: ApplicationFiled: October 2, 2008Publication date: January 6, 2011Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Josee Beaulieu, Jean-Francois Lapointe, Claude Dupont, Pierre Lemieux, Eric Simard, Eric Trottier
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Publication number: 20100298207Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:50-96, or the nucleotide sequence set forth in SEQ ID NO:1-47, as well as variants and fragments thereof.Type: ApplicationFiled: February 26, 2010Publication date: November 25, 2010Applicant: ATHENIX CORPORATIONInventors: Kimberly S. Sampson, Daniel John Tomso, Razvan Valeriu Dumitru
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Publication number: 20100298206Abstract: The present invention relates to compositions and methods for producing therapeutic oligomeric compounds. In one aspect the invention relates to methods for administering the oligomeric compounds for the treatment and prevention of disease, for example, a fungal infection, bacterial infection, or cancer, in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, pharmacologically active agent or a combination thereof.Type: ApplicationFiled: February 18, 2010Publication date: November 25, 2010Applicants: Centre National de la Recherche Scientifique (CNRS), I.B.M.C., ImmuPharma France SA, TechnopoleInventors: Aude Violette, Jean-Paul Briand, Robert H. Zimmer, Gilles Guichard
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Publication number: 20100278807Abstract: A novel class of antimicrobial polymeric agents which are designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.Type: ApplicationFiled: September 16, 2008Publication date: November 4, 2010Applicant: Technion Research & Development Foundation Ltd.Inventors: Amram Mor, Inna Radzishevsky
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Publication number: 20100267623Abstract: The invention relates to peptides of general formula (I), wherein X is absent or X is present and is X14 or X14-X15, wherein X14 and X15, independently from one another, represent an amino acid; their functional variants and fragments, and their pharmaceutically acceptable salts, having the capacity to bind to scurfin and inhibit its biological activity, therefore they regulate or block the activity of regulatory T (Treg) lymphocytes. They are applicable in the treatment of infectious and neoplastic diseases.Type: ApplicationFiled: November 14, 2008Publication date: October 21, 2010Applicant: PROYECTO DE BIOMEDICINA CIMA, S.L.Inventors: Inés Noelia Casares Lagar, Francisco Borras Cuesta, Pablo Sarobe Ugarriza, Jesús Prieto Valtueña, Juan José Lasarte Sagastibelza
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Publication number: 20100267621Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.Type: ApplicationFiled: April 20, 2007Publication date: October 21, 2010Applicant: LYTIX BIOPHARMA ASInventors: John Sigurd Svendsen, Bengt Erik Haug, Istvan Marko, Oystein Rekdal, Merete Linchausen Skar, Wenche Stensen, Morten Bohmer Strom
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Publication number: 20100256048Abstract: [Problems] To provide an antibacterial agent, particularly a novel polypeptide compound having an antifungal action. [Means for Solution] As a result of an extensive study on a novel antifungal agent, the inventors have found that an excellent anti-deep-fungal activity is exhibited by introducing a cyclohexylmethylamino group or a piperidylmethylamino group as a partial structure of a natural polypeptide compound, and completed the present invention. The compound of the present invention has an excellent antibacterial activity and is therefore useful as an agent for preventing or treating various fungal infections.Type: ApplicationFiled: October 28, 2008Publication date: October 7, 2010Applicant: Astellas Pharma Inc.Inventors: Masaki Tomishima, Hiroshi Morikawa, Takuya Makino, Masashi Imanishi, Natsuko Kayakiri, Toru Asano, Takanobu Araki, Toshiya Nakagawa