Fungus (e.g., Athlete's Foot, Ringworm, Etc.) Destroying Or Inhibiting Patents (Class 514/3.3)
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Patent number: 8906848Abstract: In general, the invention relates to methods of synthesizing AbA derivatives that are useful for treating infection and amenable to further chemical elaboration. These novel methods are scalable for industrial production and employ safer, simpler, and more efficient process conditions. Furthermore, the invention also provides novel compounds and intermediates useful for implementing the methods described herein and/or for the treatment of infection.Type: GrantFiled: March 23, 2012Date of Patent: December 9, 2014Assignee: AureoGen Biosciences, inc.Inventors: Peter Wuts, Ake P. Elhammer
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Patent number: 8889680Abstract: Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise identifying a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of an inhibitor or a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof. Inhibition of the fungal PDK-1 or homolog thereof results in the treatment or prevention of a fungal infection in the subject. Also provided are compositions comprising an inhibitor of a fungal phosphoinositide-dependent kinase 1 (PDK-1) or a homolog thereof, and a pharmaceutically acceptable carrier.Type: GrantFiled: November 17, 2011Date of Patent: November 18, 2014Assignee: University of RochesterInventors: Damian Krysan, Louis DiDone, Bonnie K. Baxter
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Patent number: 8883717Abstract: Multilayer films comprised of polypeptide epitopes and a toll-like receptor ligand are described. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a virus, bacteria, fungus or parasite.Type: GrantFiled: March 14, 2013Date of Patent: November 11, 2014Assignee: Artificial Cell Technologies, Inc.Inventors: Thomas J. Powell, James Gorham Boyd
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Publication number: 20140325703Abstract: Described are genes and chimeric genes encoding anti-microbial peptides. These genes can be used to generate transgenic plants with an improved resistance to, for example, plant pathogenic fungi. Alternatively, the peptides encoded by these genes can be applied as agrochemical formulations to plants suffering from microbial diseases such as fungal diseases.Type: ApplicationFiled: May 9, 2012Publication date: October 30, 2014Applicant: VIB VZWInventors: Frank Van Breusegem, Annelies Inze, Janick Mathys, Bruno Cammue
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Publication number: 20140309161Abstract: The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.Type: ApplicationFiled: June 20, 2012Publication date: October 16, 2014Applicant: Universitat LeipzigInventors: Ralf Hoffmann, Nicole Berthold, Friederike Nollmann
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Publication number: 20140309162Abstract: The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the antibacterial and fungicidal peptide of the present invention, in which lysine and tryptophan dipeptide is repeated four times, shows excellent antibacterial activities with respect to gram-positive bacteria, gram-negative bacteria and antibiotic-resistant strains by affecting the inner membrane of harmful microorganisms, has remarkable fungicidal activities with respect to pathogenic fungi and antibiotic-resistant fungi, and shows little cytotoxicity, and thus can be useful for a pharmaceutical composition, a cosmetic composition, agricultural chemicals, a food preservative, a cosmetic preservative, and a pharmaceutical preservative.Type: ApplicationFiled: June 27, 2014Publication date: October 16, 2014Applicant: Industry-Academic Cooperation Foundation, Chosun UniversityInventor: Yoon Kyung Park
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Publication number: 20140296135Abstract: The combination of pentraxin PTX3 with antifungals is described for the treatment of fungal infections and particularly for infections caused by Aspergillus fumigatus.Type: ApplicationFiled: June 4, 2014Publication date: October 2, 2014Inventors: Giovanni Salvatori, Paolo Carminati, Luigina Romani
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Publication number: 20140294851Abstract: Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.Type: ApplicationFiled: April 1, 2013Publication date: October 2, 2014Inventor: MARK QUANG NGUYEN
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Publication number: 20140274880Abstract: Provided is a bacterial strain which produces a family of mosquitocidal toxins, Xenorhabdus MT, on deposit with the American Type Culture Collection, PTA-6826, insecticidal compositions comprising the mosquitocidal toxin(s) produced by Xenorhabdus MT, a mosquitocidal toxin preparation prepared from spent culture medium, whole culture or cells or a mixture thereof, of Xenorhabdus MT and method of insect control, especially mosquito control. Also provided are microbial compounds (same as mosquitocidal toxins) compositions comprising them and use in formulating therapeutic and other antimicrobial compositions, and methods of use for inhibiting microbial growth and for treating infection.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: WISCONSIN ALUMI RESEARCH FOUNDATIONInventors: Jerald Coleman ENSIGN, Que LAN, David DYER
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Publication number: 20140255476Abstract: Compositions, devices, and methods for treating infections.Type: ApplicationFiled: August 20, 2012Publication date: September 11, 2014Applicant: University of Washington through its Center for CommercializationInventors: Rodney J.Y. Ho, Brenda Newman
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Publication number: 20140255299Abstract: In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.Type: ApplicationFiled: August 24, 2012Publication date: September 11, 2014Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.Inventors: Annette Khaled, Rebecca Boohaker, Michael Lee, Jesus Perez Figueroa
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Publication number: 20140235531Abstract: The present invention is directed to the peptides WKWLKKWIK, WRKFWKYLK, and RRWRVIVKW and use of said peptides as therapeutic agents for the prophylaxis and/or treatment of infections, in particular bacterial and/or fungal infections and diseases caused by bacterial and/or fungal infections.Type: ApplicationFiled: October 10, 2012Publication date: August 21, 2014Inventor: Dorian Bevec
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Patent number: 8809498Abstract: The invention relates to a compound having a structure according to the general formula P3-P2-P1-P1?-P2? (I), wherein residues P3, P2, P1, P1? and P2? are specifically defined and may be, e.g., certain amino acid residues. The invention further relates to the use of said compound and to a method for synthesizing a peptide.Type: GrantFiled: April 30, 2009Date of Patent: August 19, 2014Assignee: Freie Universitaet BerlinInventors: Claudia Borelli, Hans Christian Korting, Elisabeth Ruge, Hans Dieter Hoeltje, Robert Huber, Beate Koksch, Cosimo Damiano Cadicamo
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Publication number: 20140228279Abstract: The disclosure provides cationic peptidopolysaccharides of Formula I: which has a bacterial peptidoglycan-mimetic structure, and shows outstanding broad spectrum activities against clinically significant bacteria and fungi. The structural affinity of these compounds with microbial cell wall constituents promotes its passage to the cytoplasmic membrane resulting in excellent antimicrobial activity and record high selectivity.Type: ApplicationFiled: October 3, 2012Publication date: August 14, 2014Applicant: Nanyang Technological UniversityInventors: Bee Eng Mary Chan, Peng Li
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Publication number: 20140206601Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.Type: ApplicationFiled: February 20, 2014Publication date: July 24, 2014Applicants: Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Jean-Claude Sirard, Jose A. Chabalgoity
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Publication number: 20140208461Abstract: The present invention provides nucleic acid molecules derived from Nicotiana alata, which encode defensin-like molecules. The present invention contemplates the use of such nucleic acid molecules in the generation of transgenic plants having resistance or at least reduced sensitivity to plant pests including insects, microorganisms, fungi and/or viruses and the of the encoded defensin-like molecules in compositions for topical application to a plant or a plant part so as to reduce prevent or reduce infestation of the plant or plant part by plant pests. The transgenic plants provided by the present invention include monocotyledonous and dicotyledonous plants, and particularly include crop plants and ornamental flowering plants.Type: ApplicationFiled: March 24, 2014Publication date: July 24, 2014Applicant: HEXIMA LIMITEDInventors: Marilyn Anne ANDERSON, Fung Tso LAY, Robyn Louise HEATH
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Publication number: 20140194345Abstract: The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.Type: ApplicationFiled: December 3, 2013Publication date: July 10, 2014Inventors: Aaron J. Peoples, Dallas Hughes, Losee Lucy Ling, William Millett, Anthony Nitti, Amy Spoering, Victoria Alexandra Steadman, Jean-Yves Christophe Chiva, Linos Lazarides, Michael Kenyon Jones, Karine Gaelle Poullenec, Kim Lewis
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Patent number: 8765147Abstract: The present disclosure relates to endophytic fungi from higher plants such as a Pteromischum sp. plant, and to extracts and compounds from such fungi that have desirable biological activities, such as antifungal and immunosuppressive activities. The present disclosure further relates to compositions comprising such extracts and compounds, as well as methods of making and using the compositions.Type: GrantFiled: November 14, 2011Date of Patent: July 1, 2014Assignee: The Regents of the University of CaliforniaInventors: Gary A. Strobel, Yuhao Ren, David B. Teplow
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Patent number: 8758822Abstract: The present invention relates to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, and more particularly, to a method for manufacturing uniform size polymeric nanoparticles containing poorly soluble drugs, including a first step of dissolving a biodegradable polymer in a non-volatile polar organic solvent, a second step of adding poorly soluble drugs to water and the biodegradable polymer solution to produce a dispersion, and a third step of adding the dispersion to emulsifier solutions in a batch under the condition of low mechanical energy level stirring.Type: GrantFiled: April 30, 2009Date of Patent: June 24, 2014Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Bong Hyun Chung, Yong Taik Lim, Jung Hyun Han
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Patent number: 8754042Abstract: The present invention relates to novel agents, pharmaceutical compositions containing them, and their use in therapy, particularly anti-microbial and anti-cancer therapy. In particular, the present invention relates to novel peptide-based compounds based on SEQ ID NO:40 which have surprisingly been shown to have inhibitory effects on the growth and/or viability of cells, particularly bacterial and cancer cells. Also provided are therapeutic and non-therapeutic methods which comprise the use of peptides of the invention.Type: GrantFiled: February 1, 2011Date of Patent: June 17, 2014Assignee: Cytovation ASInventor: Lars Prestegarden
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Publication number: 20140162938Abstract: Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.Type: ApplicationFiled: December 3, 2013Publication date: June 12, 2014Applicant: The Board of Regents of the University of OklahomaInventor: Heloise Anne Pereira
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Publication number: 20140155321Abstract: The present invention relates to a polypeptide or a product comprising said polypeptide for use in the treatment and/or prevention of a fungal infection caused by Malassezia spp. and/or a Malassezia spp associated condition wherein the polypeptide comprises a sequence of about 25 to 200 amino acids wherein substantially all of the amino acids in said sequence are lysine; pharmaceutical compositions comprising said polypeptide or product and uses thereof.Type: ApplicationFiled: March 14, 2013Publication date: June 5, 2014Applicant: Novabiotics LimitedInventors: Deborah O'NEIL, Derry MERCER, Colin STEWART
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Publication number: 20140155318Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.Type: ApplicationFiled: September 3, 2013Publication date: June 5, 2014Applicant: Tel Hashomer Medical Research, Infrastructure and Services Ltd.Inventor: Amir ZLOTKIN
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Publication number: 20140147416Abstract: Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.Type: ApplicationFiled: November 26, 2013Publication date: May 29, 2014Inventors: JAMES LEIF SMITH, AKSHAYA RAVICHANDRAN, SHIEN LU, GANYU GU
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Publication number: 20140141096Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.Type: ApplicationFiled: March 15, 2013Publication date: May 22, 2014Applicant: MiMedx Group, Inc.Inventor: MiMedx Group, Inc.
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Publication number: 20140128313Abstract: Materials and methods for making and using cationic anti-microbial peptides (CAMPs), and compositions containing such peptides.Type: ApplicationFiled: April 20, 2012Publication date: May 8, 2014Inventors: Barney Bishop, Monique van Hoek
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Publication number: 20140128256Abstract: Disclosed herein is a Bacillus strain, Bacillus sp. isolate F727, that produces metabolites with pesticidal activities. Also provided are bioactive compositions and metabolites derived from cultures of Bacillus sp. isolate F727 capable of controlling pests; as well as methods of use of the strain and its metabolites for controlling pests.Type: ApplicationFiled: March 15, 2013Publication date: May 8, 2014Applicant: MARRONE BIO INNOVATIONS, INCInventors: Ratnakar Asolkar, Ana-Lucia Cordova-Kreylos, Christopher D McCort, Debora Wilk, Carly Todd, Hai Su, Pamela Marrone
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Publication number: 20140128315Abstract: Disclosed are a high purity of caspofungin or salts thereof, and a preparation method thereof, and use thereof. Disclosed are a caspofungin or salts thereof with low solvent residue and hyposaline, and a preparation process comprising: dissolving a crude product of caspofungin or slats thereof into a system of water and acetic acid, them mixing with a first organic solvent ethyl alcohol, subsequently mixing with a second organic solvent ethyl acetate, then being subject to filtration and drying together with water, to obtain caspofungin or salts thereof with high stability, low solvent residue and hyposaline.Type: ApplicationFiled: April 20, 2012Publication date: May 8, 2014Applicant: SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD.Inventors: Bingming He, Ming Li, Zhijun Tang, Xiaoming Ji
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Patent number: 8697640Abstract: The present invention is directed to a method of treating a fungal infection with a fusion peptide that includes a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia. The fungal targeting agent can be a pheromone, such as an alpha-mating pheromone. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms. The fusion peptides can be prepared from the nucleic acids, such as when a vector having the nucleic acid is included in a host cell.Type: GrantFiled: March 15, 2011Date of Patent: April 15, 2014Assignee: Pheromonicin Biotech, Ltd.Inventor: Xiao-Qing Qiu
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Patent number: 8685476Abstract: Polydimethylsiloxane and/or siloxane (silicone)-derived chemical compounds are used to coating harvested forages to protect against rain and/or other weather damage and to suppress mold and spoilage in harvested forages. The PDMS compound and derivatives thereof are also found to suppress the damage resulting from oxidation within the feedstuff mass. When applied, PDMS coats the feedstuff and is included in the moisture portion of the feed or forage mass. This helps preserve the feed quality and slows the damaging effects of spoilage organisms and oxidation.Type: GrantFiled: May 28, 2010Date of Patent: April 1, 2014Inventor: Mark L. Folkman
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Patent number: 8686113Abstract: The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus.Type: GrantFiled: January 29, 2010Date of Patent: April 1, 2014Assignee: AMP-Therapeutics GmbHInventors: Ralf Hoffmann, Daniel Knappe, Anna Klara Brigitte Hansen
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Publication number: 20140082769Abstract: The present application belongs to the field of functional peptides and more particularly to the field of controlled protein aggregation. The invention discloses molecules of a peptide structure as defined in the claims and methods of using such molecules for therapeutic applications and for diagnostic uses, as well as in other applications such as in the agbio field and in industrial biotechnology. The molecules can be used for curing and/or stabilizing infections such as bacterial, fungal and viral diseases, but are also useful in non-infectious human and veterinary diseases. The molecules can also be used for the detection of protein biomarkers and for the prognosis and diagnosis of a variety of diseases.Type: ApplicationFiled: March 12, 2012Publication date: March 20, 2014Inventors: Joost Schymkowitz, Frederic Rousseau
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Publication number: 20140056906Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.Type: ApplicationFiled: October 8, 2013Publication date: February 27, 2014Applicant: INCYTE CORPORATIONInventors: Henry Yue, Monique G. Yao, Ameena R. Gandhi, Mariah R. Baughn, Anita Swarnakar, Narinder Walia, Madhusudan M. Sanjanwala, Michael Thorton, Vicki S. Elliott, Yan Lu, Kimberly J. Gietzen, Neil Burford, Li Ding, April J. A. Hafalia, Y. Tom Tang, Olga Bandman, Bridget A. Warren, Cynthia D. Honchell, Dyung Aina M. Lu, Kavitha Thangaveln, Sally Lee, Yuming Xu, Junming Yang, Preeti G. Lal, Bao Tran, Craig H. Ison, Brendan M. Duggan, Stephanie Sapperstein
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Patent number: 8652514Abstract: Novel peptides having antimicrobial activity, and compositions containing the same.Type: GrantFiled: December 13, 2010Date of Patent: February 18, 2014Assignees: Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de LilleInventors: Aurélle Tasiemski, Michel Salzet, Françoise Gaill
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Synergistic combinations of polyene fungicides and non-ribosomal peptides and related methods of use
Patent number: 8623813Abstract: The present invention includes compositions comprising a synergistic fungicidal combination of a polyene fungicide and at least one lipopeptide and methods for using such compositions in controlling fungal pathogens.Type: GrantFiled: May 23, 2012Date of Patent: January 7, 2014Assignee: Bayer CropScience LPInventors: Magalie Guilhabert-Goya, Jonathan S. Margolis -
Publication number: 20140007303Abstract: This invention is related to a protein from the seeds, cotyledons or plantlets of Lupinus genus, as well as to the way of producing the protein in recombinant form and of expressing the protein in genetically modified plants. The invention relates to methods of its use, or of any modification of the protein that maintains its biological properties, as a supplement in human or animal nutrition and as a fungicide, insecticide, growth promoter, fertilizer or in the preparation of genetically modified organisms.Type: ApplicationFiled: August 13, 2013Publication date: January 2, 2014Applicant: INSTITUTO SUPERIOR DE AGRONOMIAInventors: Ricardo Manuel DE SEIXAS BOAVIDA FERREIRA, Sara Alexandra VALADAS DA SILVA MONTEIRO, Artur Ricardo NASCIMENTO TEIXEIRA, Virgilio BORGES LOUREIRO
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Publication number: 20130345119Abstract: The present invention provides an antimicrobial peptide polymer comprising at least one monomer which is digested by pepsin, a multimeric antimicrobial peptide complex comprising the polymer and a cell surface anchoring motif linked to the polymer, an antimicrobial microorganism displaying the multimeric antimicrobial peptide complex, an antimicrobial composition comprising the same, a method of treating an infectious disease caused by bacteria, yeast or fungi by administering the antimicrobial composition, and a method for producing the antimicrobial microorganism. According to the invention, living microorganisms displaying an antimicrobial peptide on the cell surface thereof may be administered in vivo without having to lyse the microbial cell and isolate and purify the antimicrobial peptide, so that the antimicrobial peptide exhibits antimicrobial activity. Thus, the antimicrobial peptide may be produced at significantly reduced costs so that it may have widespread use.Type: ApplicationFiled: December 28, 2010Publication date: December 26, 2013Applicants: INTELLIGENT SYNTHETIC BIOLOGY CENTER, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sun-Chang Kim, Ju Ri Shin, Ki Jung Lim, Da Jung Kim, Young Woong Lee, Su A Jang, Bong Hyun Sung
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Synergistic Combinations of Polyene Fungicides and Non-Ribosomal Peptides and Related Methods of Use
Publication number: 20130331311Abstract: The present invention includes compositions comprising a synergistic fungicidal combination of a polyene fungicide and at least one lipopeptide and methods for using such compositions in controlling fungal pathogens.Type: ApplicationFiled: August 7, 2013Publication date: December 12, 2013Applicant: Bayer CropScience LPInventors: Magalie GUILHABERT-GOYA, Jonathan S. MARGOLIS -
Patent number: 8598114Abstract: The present invention relates to a compound of formula (I) AA-AA-AA-X—Y—Z wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms; X is a N atom, which may be substituted by a branched or unbranched C1-C10 alkyl or aryl group which group may incorporate up to 2 heteroatoms selected from N, O and S; Y represents a group selected from —Ra—Rb—, —Ra—Rb—Rb— and —Rb—Rb—Ra— wherein Ra is C, O, S or N, and Rb is C; each of Ra and Rb may be substituted by C1-C4 alkyl groups or unsubstituted; and Z is a group comprising 1 to 3 cyclic groups each of 5 or 6 non-hydrogen atoms, 2 or more of the cyclic groups may be fused and one or more of the cyclic groups may be substituted; the Z moiety incorporates a maximum of 15 non-hydrogen atoms; and wherein the bond between Y and Z is a covalent bond between Ra or Rb of Y and a non-hydrogen atom of one of the cyclic groups of Z.Type: GrantFiled: December 22, 2008Date of Patent: December 3, 2013Assignee: Lytix Biopharma ASInventors: Wenche Stensen, Bengt Erick Haug, Oystein Rekdal, John Sigurd Svendsen
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Publication number: 20130315920Abstract: A complex comprising a Class II HLA-DRB1*03 or Class II HLA-DRB1*13 molecule bound to a peptide, wherein the peptide comprises the amino acid sequence HTYTIDWTKDAVTWS or a portion thereof, or a variant of the given amino acid sequence or portion wherein the side chains of one or two or three or four or five or six or seven of the amino acid residues are altered, wherein the peptide comprising the portion, or variant, is capable of binding HLA-DRB1*03 and/or HLA-DRB1*13. The complex may be used to select Aspergillus and Candida antigen-specific T cells.Type: ApplicationFiled: November 16, 2011Publication date: November 28, 2013Applicant: Cell Medica LimitedInventors: Max S. Topp, Claudia Stuehler, Nina Khanna
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Patent number: 8592367Abstract: The present invention relates to the use of at least one peptide originated from Medicago truncatula nodules, including the SEQ IDs NO: 1-463 or at least one peptide having a sequence derived from the SEQ IDs NO: 1-463 by deletion of about 9 to about 44 contiguous amino acids, from the N-terminal part of the peptide, in particular peptides having the SEQ IDS NO: 464 to 925, for the preparation of a drug intended for the treatment of human, animal or plant diseases induced by microorganisms, wherein the peptides have a broad-spectrum and fast antibiotic activity, in particular killing of the bacteria within 1 to 3 hours.Type: GrantFiled: June 15, 2010Date of Patent: November 26, 2013Assignee: Centre National de la Recherche ScientifiqueInventors: Eva Kondorosi-Kuzsel, Peter Mergaert, Willem Van de Velde, Gergely Maroti, Attila Farkas, Attila Kereszt
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Publication number: 20130310307Abstract: The invention provides a method of killing an infectious microbe by administering an effective amount of transferrin to an individual having a microbial infection, wherein the transferrin has microbicidal activity, thereby reducing survival of the infectious microbe in the individual. The invention also provides a method of prophylactically treating an individual to decrease the likelihood of contracting a microbial infection, comprising administering an effective amount of transferrin to an individual, wherein the transferrin has microbicidal activity, thereby decreasing the likelihood that the individual will contract a microbial infection. The invention still further provides a method of treating septicemia by administering an effective amount of transferrin to an individual in need thereof, thereby treating the individual.Type: ApplicationFiled: March 13, 2013Publication date: November 21, 2013Applicant: LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTERInventors: Brad J. SPELLBERG, Lin LIN
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Publication number: 20130288953Abstract: The inventors provide the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to prevent or inhibit spoilage of a foodstuff by a microorganism. Also provided is a method of preventing or inhibiting spoilage of a foodstuff by a microorganism comprising administering to a foodstuff in need thereof an effective amount of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof.Type: ApplicationFiled: October 12, 2011Publication date: October 31, 2013Applicant: CONSUMO EM VERDE-BIOTENOLOGIA DAS PLANTAS S.A. (PT/PT)Inventors: Alexandra Manuela Lourenço Carreira, Sara Alexandra Valadas Da Silva Monteiro, Ricardo Manuel De Seixas Boavida Ferreira
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Publication number: 20130288954Abstract: The inventors provide the use of a chelating agent and an antimicrobial agent that is effective against a plant pathogenic microorganism to inhibit the growth of and/or kill a plant pathogenic microorganism on a plant; the use of a chelating agent to increase the activity of an antimicrobial that is effective against a plant pathogenic microorganism; a method of inhibiting the growth of and/or killing a plant pathogenic microorganism comprising administering to a plant in need thereof a chelating agent and an antimicrobial agent that is effective against a plant pathogenic microorganism; and a method of increasing the activity of an antimicrobial that is effective against a plant pathogenic microorganism comprising using said antimicrobial with a chelating agent.Type: ApplicationFiled: October 12, 2011Publication date: October 31, 2013Applicant: CONSUMO EM VERE-BIOTECNOLOGIA DAS PLANTAS S.A. (PT/PT)Inventors: Alexandra Manuela Lourenço Carreira, Ricardo Manuel De Seixas Boavida Ferreira, Sara Alexandra Valadas Da Silva Monteiro
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Publication number: 20130280297Abstract: The invention provides immunomodulatory proteins, e.g., useful to prevent, inhibit or treat microbial infection.Type: ApplicationFiled: March 14, 2013Publication date: October 24, 2013Inventors: Lori Neal, Laura Knoll, Erik Settles, Lindsey Anne Moser
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Publication number: 20130267459Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: ApplicationFiled: March 15, 2013Publication date: October 10, 2013Inventors: Robyn Louis Heath, Marilyn Anne Anderson, Nicole Louise van der Weerden, James Anthony McKenna, Simon Poon
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Publication number: 20130269059Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: ApplicationFiled: March 15, 2013Publication date: October 10, 2013Applicant: Hexima LimitedInventors: Robyn Louise HEATH, Marilyn Anne Anderson, Nicole Louise van der Weerden, James Anthony McKenna, Simon Poon
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Publication number: 20130263326Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: ApplicationFiled: March 15, 2013Publication date: October 3, 2013Inventors: Robyn Louise HEATH, Marilyn Anne Anderson, Nicole Louise van der Weerden, James Anthony McKenna, Simon Poon
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Publication number: 20130252880Abstract: Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.Type: ApplicationFiled: February 19, 2013Publication date: September 26, 2013Applicant: NEW YORK UNIVERSITY SCHOOL OF MEDICINEInventor: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
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Publication number: 20130244928Abstract: The peptides and derivative metapeptides based upon natural antimicrobial peptides have potent and broad spectrum activity against pathogens exhibiting multiple antibiotic resistance. Specific peptides can also potentiate the antimicrobial functions of leukocytes, such as neutrophils. In addition, they exhibit lower inherent mammalian cell toxicities than conventional antimicrobial peptides, and overcome problems of toxicity, immunogenicity, and shortness of duration of effectiveness due to biodegradation, retaining activity in plasma and serum. The peptides and derivative metapeptides exhibit rapid microbicidal activities in vitro, can be used to potentiate conventional antimicrobial agents, to potentiate other antimicrobial peptides and are active against many organisms that exhibit resistance to multiple antibiotics currently in existence.Type: ApplicationFiled: February 19, 2013Publication date: September 19, 2013Applicant: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterInventors: Michael R. YEAMAN, Alexander J. Shen