The Hetero Ring Has Exactly 15 Ring Carbons Patents (Class 514/30)
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Publication number: 20120289470Abstract: The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam, carprofen, enrofloxacin, clemastine, diphenhydramine, digoxin, levothyroxine, cyclosporine, ondansetron, lysine, zolpidem, propofol, nitenpyram, ivermectin, milbemycin, and pharmaceutically acceptable salts, solvates and esters thereof. In another embodiment, the invention includes methods of treating or preventing a condition in an animal comprising transmucosally administering a composition comprising a therapeutically or prophylactically effective amount of an active agent and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 15, 2011Publication date: November 15, 2012Inventors: Mark C. HEIT, Antonio M. BENITZ, Dennis F. STEADMAN, David M. PETRICK
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Publication number: 20120277175Abstract: This invention relates to antihelminthic pharmaceutical combinations comprising iodinated aromatic compounds, such as disophenol or nitroxynil, with other pharmaceutical active ingredients targeting the treatment of animals. More specifically, this invention concerns pharmaceutical compositions comprising disophenol or nitroxynil with at least one other pharmaceutical antihelminthic active ingredient, selected from among benzimidazoles, thiabendazole, levamisole or tetramisole salts, avermectins or milbemycins and, even more preferably, levamisole salts selected from between levamisole chloride or phosphate. This invention also relates to medications and a method for treating animals comprising such antihelminthic medications.Type: ApplicationFiled: November 5, 2010Publication date: November 1, 2012Applicant: Ouro Finp Partcipaccoes e Empreedimentos SAInventors: Dolivar Coracci Neto, Nelson Henriques Fernandes Filho, Ricardo da Silva Sercheli
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Patent number: 8299036Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, cyclic ketoenols or other acaricidally active compounds and, secondly, further insecticidally active compounds from the group of the anthranilamides, which combinations are highly suitable for controlling animal pests, such as insects and unwanted acarids.Type: GrantFiled: October 10, 2004Date of Patent: October 30, 2012Assignee: Bayer CropScience AGInventors: Christian Funke, Thomas Bretschneider, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Anton Kraus
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Publication number: 20120264602Abstract: The present invention provides: a composition for controlling pests comprising, as active ingredients, ethaboxam and avermectin; a method for controlling pests which comprises applying effective amounts of ethaboxam and avermectin to a pest, a plant or soil for growing plant; and so on.Type: ApplicationFiled: December 22, 2010Publication date: October 18, 2012Inventor: Makoto Kurahashi
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Patent number: 8288426Abstract: A composition comprising fenamidone (a) and an insecticide compound (b) in a (a)/(b) weight ratio of from 1/1000 to 1000/1. A composition further comprising an additional fungicidal compound. A method for preventively or curatively combating the pests and diseases of crops by using this composition.Type: GrantFiled: December 21, 2007Date of Patent: October 16, 2012Assignee: Bayer CropScience AGInventors: Heike Hungenberg, Wolfgang Thielert, Koen Van Den Eynde
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Publication number: 20120258062Abstract: Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.Type: ApplicationFiled: June 21, 2012Publication date: October 11, 2012Applicant: Galderma S.A.Inventors: Vincent MANETTA, Gary R. Watkins
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Publication number: 20120255502Abstract: A method of treatment and a package that is designed to accomplish this. The package provides the pet owner with a pack containing individual doses of topically applied medications pre-packaged with an oral taste treat. The topically applied medication contains at least one pharmaceutically active ingredient selected from the group of chemical families comprising phenylpyrazoles, macrocyclic lactones, neonicotinoids, synthetic pyrethroids, insect growth regulators, amidines, semicarbazones, spinosyns, octadepsipeptides, and pyrazinoisoquinolines, or any combination thereof. The treat can be administered either before the topically applied treatment is given so as to relax and distract the pet, or after the treatment is given so as to reward the pet and help it forget the stress of treatment. The treat can also be shaped to signify the type of animal to be treated.Type: ApplicationFiled: March 29, 2012Publication date: October 11, 2012Applicant: ALLEVA ANIMAL HEALTH LIMITEDInventor: Robert HOLMES
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Publication number: 20120245114Abstract: The present invention provides a method for the prevention/treatment of bark beetle and/or wood borer infestation of trees comprising treatment of the tree with a composition comprising a macroyclic lactone.Type: ApplicationFiled: June 5, 2012Publication date: September 27, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Donald M. Grosman, David Cox
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Publication number: 20120238516Abstract: The present invention relates to anthelmintic compositions comprising two or more anthelmintic active agents selected from one or more of the following groups; imidazothiazoles such as levamisole, benzimidazoles such as oxfendazole, or fenbendazole, macrocylic lactones such as ivermectin or avermectin, salicylanilides, and praziquantel. The composition being in the form of stable granules that are readily dispersible in water so as to provide a homogenous mixture of the anthelmintic agents suitable for administration. Methods of preparing the composition are also described.Type: ApplicationFiled: March 7, 2012Publication date: September 20, 2012Inventors: Douglas Robert Cleverly, Debashis Mukhopadhyay
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Publication number: 20120238517Abstract: The present invention relates to compounds of formula (I): Wherein A1, A2, A3, A4, G1, L, Y1, Y2, Y3, Y4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermediates for preparing compounds of formula (I), to compositions comprising them and to methods of using them to combat and control insect, acarine, nematode and mollusc pests.Type: ApplicationFiled: December 1, 2010Publication date: September 20, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Jerome Yves Cassayre, Peter Renold, Myriem El Qacemi, Thomas Pitterna, Julie Clementine Toueg
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Publication number: 20120232026Abstract: The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W1, W2, W3, W, Y, X, R1a, R1b, R1c, R2, R3, R4, n, and “” are as described herein.Type: ApplicationFiled: March 8, 2012Publication date: September 13, 2012Applicant: PFIZER INC.Inventors: Michael Curtis, Sanjay Menon, Valerie A. Vaillancourt, Nathan Anthony Logan Chubb, Denis Billen, Sean David William Greenwood, Timothy Lee Stuk
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Patent number: 8263566Abstract: What is described are a compound of the formula wherein n is 0 or 1; A-B is —CH?CH— or —CH2—CH2—; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example C1-C12-alkyl, C2-C12-alkenyl or C2-C12-alkinyl; which are optionally substituted with one to five substituents selected from the group consisting of OH, halogen, CN, —N3, —NO2, C3-C8-Cycloalkyl, norbornylenyl-, C3-C8-Cycloalkenyl; C3-C8-halocycloalkyl, C1-C12-alkoxy, C1-C6-alkoxy-C1-C6-alkoxy, C3-C8-cycloalkoxy, C1-C12-haloalkoxy, C1-C12-alkylthio, C3-C8-cycloalkylthio, C1-C12-haloalkylthio, C1-C12-alkylsulfinyl, C3-C8-cycloalkylsulfinyl, C1-C12-haloalkylsulfinyl, C3-C8-halocycloalkylsulfinyl, C1-C12-alkylsulfonyl, C3-C8-cycloalkylsulfonyl, C1-C12-haloalkylsulfonyl, C3-C8-halocycloalkylsulfonyl, —NR4R6, —X—C(?Y)—R4, —X—C(?Y)—Z—R4, —P(?O)(OC1-C6-alkyl)2, aryl, heterocyclyl, aryloxy, arylthio and heterocyclyloxy; R3 is for example H, C1-C12-alkyl or C1-C12-alkyl which is optionally substituted and, where applicable, to E/Z isomers, mixtuType: GrantFiled: May 27, 2011Date of Patent: September 11, 2012Assignee: Merial LimitedInventors: Peter Maienfisch, Fiona Murphy Kessabi, Jerome Cassayre, Laura Quaranta, Thomas Pitterna, Ottmar Franz Hueter, Pierre Jung
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Publication number: 20120225123Abstract: The disclosure relates to a method of treating a hematological malignancy comprising administering to a subject in need thereof a synergistic combination of a first compound comprising an effective amount of one or more Avermectins and a second compound comprising a chemotherapeutic, preferably daunorubicin, cyarabine, doxorubicin, idarubicin mitoxantrone, amsacrine, and mixtures thereof.Type: ApplicationFiled: November 9, 2010Publication date: September 6, 2012Applicant: UNIVERSITY HEALTH NETWORKInventors: Aaron David Schimmer, Sumaiya Sharmeen, Marko Skrtic
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Publication number: 20120225779Abstract: A pesticidal composition comprising a pesticide, an ammonium salt, and a nonionic surfactant, is provided.Type: ApplicationFiled: May 18, 2012Publication date: September 6, 2012Applicant: Dow AgroSciences LLCInventors: Jonathan M. Babcock, Steven P. Nolting
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Publication number: 20120220456Abstract: Microencapsulated formulations of macrolide lactones (abamectin, milbemectin, milbemycins emamectin, avermectins, ivermectins) wherein the active ingredient is protected from UV-degradation, with exceptional release characteristics resembling those of an emulsion concentrate or, if desired, of long-lasting effect; further with appropriate rheological properties, and with reduced toxicity. The invention provides a unique microencapsulation process for the chemical stability and biological activity of mectins, e.g. abamectin, and provides microcapsules of mectins to be used in formulations CS, WG/CS, ZC, EC/CS and any formulation type containing microcapsules and combination with other biologically active ingredients.Type: ApplicationFiled: August 7, 2009Publication date: August 30, 2012Inventors: Victor Casaña Giner, Miguel Gimeno Sierra, Barbara Gimeno Sierra
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Publication number: 20120208779Abstract: Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: ApplicationFiled: February 22, 2012Publication date: August 16, 2012Applicant: Intervet International B.V.Inventors: Fritz Blatter, Timo Rager, Ralf Warras
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Patent number: 8241669Abstract: A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.Type: GrantFiled: January 22, 2010Date of Patent: August 14, 2012Assignee: Wyeth LLCInventors: Shobhan S. Sabnis, Jon Hayes, Jack A. Zupan
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Publication number: 20120196821Abstract: An aqueous micellar formulation for localised topical application to an animal for the concurrent control of internal and external parasites in and on the animal, the formulation comprising a water-miscible co-solvent, a fatty alcohol alkoxylate, a macrocyclic lactone and water. Also described is a method for the concurrent control of internal and external parasites in and on an animal, the method comprising administering to the animal by localised topical application an aqueous micellar formulation comprising a macrocyclic lactone.Type: ApplicationFiled: October 18, 2010Publication date: August 2, 2012Inventors: Roger Mervyn Sargent, Peter Andrew O'Neill
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Patent number: 8227429Abstract: This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: GrantFiled: July 26, 2007Date of Patent: July 24, 2012Assignee: Intervet International B.V.Inventors: Ralf Warrass, Fritz Blatter, Meinrad Brenner, Guixan Hu, Tamo Rager
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Publication number: 20120171183Abstract: This invention provides a composition comprising a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure, and an effective amount of at least one fungicide.Type: ApplicationFiled: March 6, 2012Publication date: July 5, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Publication number: 20120156262Abstract: Disclosed is an insecticidal suspension concentrate composition comprising by weight based on the total weight of the composition: (a) from about 0.3 to about 30% of 3-bromo-1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-1H-pyrazole-5-carboxamide; (b) from about 5 to about 70% of a nonionic ethylene oxide-propylene oxide block copolymer component having a water solubility of at least about 5% by weight at 20° C., a hydrophilic-lipophilic balance value ranging from about 5 to about 18 and an average molecular weight ranging from about 900 to about 20000 daltons; and (c) from about 20 to about 95% of water. Also disclosed is a method for controlling an insect pest comprising diluting said suspension concentrate composition with water to form a diluted composition, and contacting the insect pest or its environment with an insecticidally effective amount of said diluted composition.Type: ApplicationFiled: September 3, 2010Publication date: June 21, 2012Inventors: Oiver Walter Gutsche, John Henry Green
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Publication number: 20120141574Abstract: A palatable, edible soft chewable medication vehicle for delivery of a pharmaceutically acceptable active ingredient, such as a drug, to an animal or human subject. The edible soft chews contain only food grade or better inactive ingredients, and preferably do not contain ingredients of animal origin. Processes for manufacturing the edible soft chews do not require the use of heat or the addition of water during mixing of active and inactive ingredients, provide stable concentrations of the active ingredient, and produce chews of consistent weight and texture.Type: ApplicationFiled: February 14, 2012Publication date: June 7, 2012Inventors: Neil E. Paulsen, Roland Johnson, Michael Coffee
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Publication number: 20120122808Abstract: Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, among other uses, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Applicant: INTERVET INTERNATIONAL B.V.Inventors: Ralf Warrass, Fritz Blatter, Meinrad Brenner, Guixan Hu, Timo Rager
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Publication number: 20120121668Abstract: A process for the preparation of a composition intended for the oral administration of active principles with unacceptable taste, which comprises from about 15% to about 30% of organoleptically unpleasant active ingredient (principle) that is mixed with from about 60% to about 80% of an ester of glycerol or of a fatty acid, to which a wax is optionally added and to which a surfactant is added, and in that it is prepared by a spray-cooling process which can produce a particle size of less than 350 ?m.Type: ApplicationFiled: January 27, 2012Publication date: May 17, 2012Applicant: AVENTIS PHARMA S.A.Inventors: Isabelle CHACORNAC, Patricia PROBECK
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Publication number: 20120122680Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein X is O or S; Y is O or S; Z is a direct bond, O, S(O)n, NR6, C(R7)2O, OC(R7)2, C(?X1), C(?X1)E, EC(?X1), C(?NOR8) or C(?NN(R6)2); a is 0, 1, 2 or 3; and R1, R2, R3, R4, R5a, R5b, R6, R7, R8, X1 and E are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.Type: ApplicationFiled: August 3, 2010Publication date: May 17, 2012Applicant: E.I. Du Pont de Nemours and CompanyInventors: Caleb William Holyoke, JR., Wenming Zhang, kanu Maganbhai Patel, George Philip Lahm, My-Hanh Thi Tong
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Publication number: 20120122679Abstract: Disclosed are compounds of Formula 1, N-oxides and salts thereof, wherein X is O or S; Y is O or S; Z is a direct bond, O, S(O)n, NR6, C(R7)2O, OC(R7)2, EC(?X1); a is 1, 2 or 3; and R1, R2, R3, R4, R5a, R5b, R6, R7, X1 and E are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention.Type: ApplicationFiled: August 3, 2010Publication date: May 17, 2012Applicant: E. I. Du Pont De Nemours and CompanyInventors: Wenming Zhang, Caleb William Holyoke, JR., Kenneth Andrew Hughes, George Philip Lahm, Thomas Francis Pahutski, JR., My-Hanh Thi Tong, Stephen Frederick McCann
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Publication number: 20120115803Abstract: The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of Acinetobacter, said method comprising using said antibiotic together with an alginate oligomer. The Acinetobacter may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with Acinetobacter. In another aspect the method can be used to combat Acinetobacter contamination of a site e.g., for disinfection and cleaning purposes.Type: ApplicationFiled: June 3, 2010Publication date: May 10, 2012Applicant: ALGIPHARMA ASInventors: Edvar Onsoyen, Rolf Myrvold, Arne Dessen, David Thomas, Timothy Rutland Walsh
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Publication number: 20120114624Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; and R1, R2, R3, Q and n are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.Type: ApplicationFiled: May 4, 2010Publication date: May 10, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: George Philip Lahm, Renee M. Lett, Brenton Todd Smith, Benjamin Kenneth Smith, C. Anne Daly
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Publication number: 20120115722Abstract: Disclosed are compositions comprising (a) at least one compound selected from compounds of Formula 1, N-oxides, and salt thereof, wherein R1 is phenyl optionally substituted with up to 5 substituents independently selected from R3, or pyridinyl optionally substituted with up to 4 substituents independently selected from R3; R2 is C1-C4 haloalkyl; or thiazolyl, pyridinyl or pyrimidinyl, each optionally substituted with up to 2 substituents independently selected from the group consisting of halogen and C1-C4 alkyl; each R3 is independently halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C(R4)?NOR4 or Q; each R4 is independently C1-C4 alkyl; Z is CH?CH or S; and each Q is independently phenyl or pyridinyl, each optionally substituted with up to 3 substituents independently selected from the group consisting of halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy and C1-C4 haloalkoxy; and (b) at least one invertebrate pest control agent.Type: ApplicationFiled: August 3, 2010Publication date: May 10, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Caleb William Holyoke, JR., Wenming Zhang, My-Hanh Thi Tong
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Patent number: 8168597Abstract: The present invention is directed to a method for treating cystic fibrosis. The method comprises the steps of: identifying a patient suffering from cystic fibrosis, and administering to the patient an effective amount of denufosol or a pharmaceutically acceptable salt thereof and an effective amount of a macrolide. In one method, denufosol and the macrolide are administered by inhalation, preferably in a single formulation. In another method, denufosol is administered by inhalation and the macrolide is administered orally. The present invention is also directed to a pharmaceutical formulation comprising denufosol or a pharmaceutically acceptable salt thereof, a macrolide, and a pharmaceutically acceptable carrier. Preferred denufosol is denufosol tetrasodium and preferred macrolide is azithromycin. The pharmaceutical formulation preferably is in a form of an inhalable dry powder or in a liquid form.Type: GrantFiled: October 21, 2009Date of Patent: May 1, 2012Assignee: Inspire Pharmaceuticals, Inc.Inventors: Donald J. Kellerman, Ramesh Krishnamoorthy, José L. Boyer, Amy E. Schaberg
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Publication number: 20120087876Abstract: Pharmaceutical/dermatological compositions containing at least one avermectin compound, e.g., ivermectin and metronidazole or salt, ester or derivative thereof, are useful for treating afflictions of the skin, especially rosacea.Type: ApplicationFiled: August 4, 2011Publication date: April 12, 2012Applicant: Galderma, S.A.Inventors: ALEXANDRE KAOUKHOV, COLETTE PERNIN
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Patent number: 8153601Abstract: The invention provides an azithromycin-containing aqueous pharmaceutical composition, which comprises at least one member selected from the group consisting of azithromycin, and pharmaceutically acceptable salts thereof, and at least one member selected from the group consisting of monoethanolamine, diethanolamine, triethanolamine, and pharmaceutically acceptable salts thereof, and which does not comprise boric acid or pharmaceutically acceptable salts thereof, and a method for the preparation of the composition, wherein an azithromycin-containing liquid is maintained at pH of 4.0 or higher throughout the method for the preparation. The composition has good heat and storage stability.Type: GrantFiled: December 20, 2006Date of Patent: April 10, 2012Assignee: Wakamoto Pharmaceutical Co., Ltd.Inventors: Hidekazu Suzuki, Kuniko Koichi, Kouhei Yoda
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Publication number: 20120083463Abstract: The present invention relates to active compound combinations consisting, firstly, of a known halogen-substituted derivative (component A) and, secondly, of further known pesticidally active compounds (component B), which active compound combinations are suitable for controlling animal and microbial pests.Type: ApplicationFiled: July 8, 2011Publication date: April 5, 2012Applicant: Bayer CropScience AGInventors: Michael MAUE, Friedrich August MÜHLTHAU, Isabelle ADELT, Markus HEIL, Peter JESCHKE, Tobias KAPFERER, Alexander SUDAU, Heike HUNGENBERG
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Publication number: 20120077764Abstract: Novel formulations containing a fluorinated chloramphenicol or thiamphenicol derivative antibiotic such as florfenicol, and methods for using such formulations in the treatment and prevention of infectious diseases of bovines and swine, including bovine respiratory disease.Type: ApplicationFiled: September 2, 2011Publication date: March 29, 2012Inventors: Keith A. FREEHAUF, Allan Weingarten, Robert D. Simmons, Kanwal Jit Varma
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Publication number: 20120077765Abstract: This invention recites naphthyl isoxazoline oxime derivatives of Formula (1) geometric isomers, stereoisomers thereof, pharmaceutically or veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in animals. The variables, R1a, R1b, R1c, R2, R3, and are as described herein.Type: ApplicationFiled: September 15, 2011Publication date: March 29, 2012Applicant: PFIZER INC.Inventors: Michael Curtis, Edmund L. Ellsworth
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Publication number: 20120077766Abstract: Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.Type: ApplicationFiled: December 2, 2011Publication date: March 29, 2012Applicant: Galderma S.A.Inventors: Vincent MANETTA, Gary R. WATKINS
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Publication number: 20120070482Abstract: A composition comprising a pesticide (A) selected from avermectin and a photo-protecting agent, wherein the mean diameter of the pesticide (A) particles is from 0.1 to 100 ?m and where the amount of photo-protecting agent in the composition does not exceed 20% of the total weight of the pesticide (A) particles plus the agent, and its use in agriculture. The avermectin particles are preferably coated with the photo-protecting agent.Type: ApplicationFiled: March 12, 2010Publication date: March 22, 2012Applicant: SYNGENTA CROP PROTECTION, LLCInventors: Alexander Mark Heming, Andrew James Pierce, Johanna Martina Williams
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Publication number: 20120058964Abstract: Disclosed are novel formulations for the treatment of otic infections in an animal comprising a triazole anti-fungal compound, a quinolone antibiotic and a corticosteroid such as mometasone furoate monohydrate.Type: ApplicationFiled: November 10, 2011Publication date: March 8, 2012Inventors: Abu S. HUQ, Allan J. Weingarten, Robert D. Simmons
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Publication number: 20120052108Abstract: Disclosed is a drug delivery system from which a macrocyclic lactone can be released with a desirable zero order release profile. The system is based on the use of thermoplastic polymers, and particularly of polyethylene vinyl acetate copolymers (EVA). The drug delivery system of the invention comprises a solid non-porous reservoir in which the macrocyclic lactone is contained, preferably in a concentration well above the saturation concentration, and a non-porous skin covering the reservoir not initially loaded with the drug. The system is preferably in the form of a rod, wherein the core and the skin are concentric, and the end surfaces of the rod are not skin-covered.Type: ApplicationFiled: March 16, 2010Publication date: March 1, 2012Inventors: Wouter De Graaff, Raymond Zeeman, Niels Honcoop
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Publication number: 20120053140Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.Type: ApplicationFiled: June 14, 2011Publication date: March 1, 2012Applicant: Galderma S.A.Inventors: Alexandre KAOUKHOV, Christophe VILLARD, Philippe BOUISSOU
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Publication number: 20120035123Abstract: A combination of compounds for treating skin diseases and particularly rosacea and ocular rosacea is described. The combination of a compound of the avermectin family or of the mylbemycin family with a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists is also described. In addition, a product in the form of a kit including: (a) a first composition containing a compound of the avermectin family or of the mylbemycin family, and (b) a second composition different from the first one and containing a compound of the family of the alpha-1 or alpha-2 adrenergic receptor agonists, as a combination product to be used as a drug for treating and/or preventing skin diseases and particularly rosacea and ocular rosacea, wherein said first and second compositions can be applied simultaneously, separately or with a time delay is described.Type: ApplicationFiled: February 16, 2010Publication date: February 9, 2012Applicant: Galderma Research & DevelopmentInventors: André Jomard, Laurent Fredon, Olivier Roye
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Publication number: 20120035122Abstract: This invention recites isoxazoline substituted azetidine derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in mammals and birds. R1a, R1b, R1c, R2, R3, R4, R6, and n are as described herein.Type: ApplicationFiled: August 4, 2011Publication date: February 9, 2012Inventors: Valerie A. Vaillancourt, Nathan Anthony Logan Chubb, Michael Curtis, William Howson, Graham M. Kyne, Sanjay Menon, Susan M. K. Sheehan, Donald J. Skalitzky, John A. Wendt
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Publication number: 20120027741Abstract: The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against fungal diseases or insect damages, and the corresponding methods of protection by application of the said composition. More precisely, the subject of the present invention is a pesticide composition based on a tetrazolyloxime derivative and a fungicide or an insecticide active substance or compound.Type: ApplicationFiled: February 18, 2010Publication date: February 2, 2012Inventors: Pierre-Yves Coqueron, Daniela Portz, Ulrike Wachendorff-Neumann
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Publication number: 20120021905Abstract: The present invention relates to synergistic mixtures comprising, as active components, insecticidal or nematicidal compound I selected from the group consisting of macrolide compounds, a carboxamide and a further insecticidal compound III selected from the group consisting of nicotinic receptor agonists/antagonists compounds or from fipronil or ethiprole in synergistic effective amounts.Type: ApplicationFiled: February 9, 2010Publication date: January 26, 2012Applicant: BASF SEInventors: Dirk Voeste, Ronald Wilhelm
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Publication number: 20120015896Abstract: A novel compound that has antimicrobial activity against penicillin-resistant Streptococcus pneumoniae, and an anti-penicillin resistant pneumococci agent that includes the compound as an active ingredient are provided. Thus, an anti-penicillin resistant pneumococci agent is provided that includes as an active ingredient a compound represented by the following formula (I) or a pharmacologically acceptable salt thereof, or hydrates thereof: wherein, in the formula (I), R represents any one of a halogen atom, an azido group, Ra-Wa-, Rb-Wb-, Rc-Wc-, and RdRd?N—.Type: ApplicationFiled: September 23, 2011Publication date: January 19, 2012Inventors: Toshiaki Miyake, Yoshiaki Takahashi
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Publication number: 20120015895Abstract: A method of promoting or improving the feed efficiency and the muscle-to-fat ratio in animals by administering to the animals a therapeutically effective amount of a mixture of RR-ractopamine and SR-ractopamine is disclosed. Manufacturing methods for making RR/SR-ractopamine are presented.Type: ApplicationFiled: September 8, 2011Publication date: January 19, 2012Applicant: BRIDGE PHARMA, INC.Inventor: A.K.Gunnar Aberg
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Patent number: 8097266Abstract: This invention relates to pharmaceutical and veterinary formulations providing enhanced solvency and stability for pharmaceutical and veterinary agents for administration to animals, especially ruminants. In addition, the invention relates to pour-on formulations for combating parasites in animals, such as cattle and sheep. In some embodiments, this invention provides glycol-ether-based pour-on formulations comprising a composition comprising a flukicide, such as, for example, clorsulon (4-amino-6-trichloroethenyl-1,3-benzene disulfonamide) and/or a macrolide anthelmintic or antiparasitic agent. In other embodiments, the invention provides pour-on formulations comprising at least one active agent, a glycol ether, and a stability enhancer. This invention also provides for methods for eradicating, controlling, and/or preventing parasite infestation in animals, such as cattle and sheep.Type: GrantFiled: November 26, 2008Date of Patent: January 17, 2012Assignee: Merial LimitedInventors: Ronald Peter Gogolewski, Douglas Cleverly, Paul Thwaites, Mark David Soll
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Publication number: 20120010161Abstract: The present invention relates to compounds of azapeptide or azapeptidomimetic type of formula (I): in which R1, R2, R3, X1, X2, X3, X4 and Y are as defined in claim 1, to pharmaceutical compositions containing them and to such compounds as adjuvant for an anticancer or anti-infectious medicament.Type: ApplicationFiled: January 25, 2010Publication date: January 12, 2012Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON IInventor: Joelle Paris
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Publication number: 20120009262Abstract: A medical device that includes at least one antibiotic in a macromolecular substance that swells upon contact with a solvent. Also, a method for preparing an antibiotic-containing medical device that involves contacting a medical device having at least a portion of the surface formed from a swellable macromolecular substance, with a solvent that swells the macromolecular substance, contacting the swollen macromolecular substance with at least one antibiotic, and removing the solvent from the swollen macromolecular substance.Type: ApplicationFiled: September 21, 2011Publication date: January 12, 2012Applicant: TYCO HEALTHCARE GROUP LPInventors: Kenichi Amano, Yoshimi Akaike
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Patent number: 8093219Abstract: Dermatological conditions/afflictions such as rosacea, common acne, seborrheic dermatitis, perioral dermatitis, acneform rashes, transient acantholytic dermatosis, and acne necrotica miliaris, most notably rosacea, are treated by topically applying onto the affected skin area of an individual in need of such treatment, a topical pharmaceutical composition which comprises a thus effective amount of ivermectin.Type: GrantFiled: June 12, 2009Date of Patent: January 10, 2012Assignee: Galderma S.A.Inventors: Vincent Manetta, Gary R. Watkins