Ascorbic Acid Or Derivative (e.g., Vitamin C, Etc.) Patents (Class 514/474)
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Patent number: 7335384Abstract: The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease states and conditions associated with neurogenic inflammation. Such disease states and conditions include, but are not limited to, migraine headache, arthritis and fibromyalgia. The composition comprises nutrient compounds in a novel combination and formulation to treat and/or prevent neurogenic inflammation and disease states and conditions associated therewith. By reducing neurogenic inflammation, the compositions of the present disclosure reduce the symptoms associated with neurogenic inflammation, such as pain and systemic inflammation in general.Type: GrantFiled: March 17, 2006Date of Patent: February 26, 2008Assignee: 4K Nutripharma InternationalInventor: F. Mahnaz Khaled
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Publication number: 20080031869Abstract: The pain relief composition is a combination of dietary and nutritional supplements that has been found effective for the relief of pain arising from a wide variety of diseases and injuries, regardless of severity or chronicity. The composition is formulated for oral administration, such as a tablet, soft gel capsule, liquid, or the like. The pain relief composition includes: at least one omega fatty acid; at least one antioxidant; and at least one amino acid.Type: ApplicationFiled: August 2, 2007Publication date: February 7, 2008Inventor: Juliette S. Fontaine
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Publication number: 20080026078Abstract: A nasal spray solution for use as a nasal spray and methods of using the solution are disclosed. The nasal spray solution moisturizes nasal passages and alleviates nasal dryness. The solution includes a hypotonic saline solution, wherein the saline solution is hypotonic with respect to cells of the nasal mucosa of the nasal passages, a buffering agent, a lubricating agent, and an anti-microbial agent.Type: ApplicationFiled: July 25, 2007Publication date: January 31, 2008Inventors: James ZINREICH, Eva ZINREICH, Helen Zinreich SHAFER
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Patent number: 7323452Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.Type: GrantFiled: December 20, 2004Date of Patent: January 29, 2008Assignee: Wardan, L.L.C.Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
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Publication number: 20080019957Abstract: A method of treating skin changes and conditions in human skin including applying a topical preparation that includes an active agent including probucol, a derivative of probucol or a combination of probucol and a derivative of probucol.Type: ApplicationFiled: July 20, 2007Publication date: January 24, 2008Inventors: Birgit Neudecker, Falko Diedrich, Eberhard Wieland
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Patent number: 7320803Abstract: Crystalline ascorbate, in particular choline ascorbate in the form of crystals free from water of crystallization, processes for its preparation, and its used are described.Type: GrantFiled: February 19, 2002Date of Patent: January 22, 2008Assignee: BASF AktiengesellschaftInventors: Ludwig Völkel, Alfred Oftring, Oliver Hasselwander, Ulrike Sindel, Klaus Krämer
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Publication number: 20080008734Abstract: A method and/or composition for monitoring electrical signals from a patient through a biomedical electrode or delivering an effective amount of electrical stimulation to said patient without causing erythema which comprises providing an antioxidant to the skin of said patient via solution, lotion, or gel prior to adhering said biomedical electrode thereto or incorporating in the hydrogel conductive adhesive of the electrode for antioxidant activity during electrical contact. Chemical precursors of some antioxidants are utilized for the manufacture and stable incorporation into hydrogel conductive adhesives to avoid interference with the preparation of the conductive adhesive by free radical polymerization.Type: ApplicationFiled: July 5, 2006Publication date: January 10, 2008Inventors: James J. Perrault, Solomon Shenkute, Svitlana Kroll
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Publication number: 20080008666Abstract: Measured of airway in samples a mammal, such as a human being, having oral malodor are analyzed for the presence of markers for the oral malodor. The mammal may subsequently be treated for this condition, and measured samples of airway breath again taken to determine the effectiveness of the treatment.Type: ApplicationFiled: March 14, 2005Publication date: January 10, 2008Inventor: Michael Phillips
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Publication number: 20070281882Abstract: Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican and keratocan. Insulin plus ascorbate, however, stimulates the synthesis of collagen and increased the accumulation of these proteoglycans. The accumulation of PGDS, a KSPG that does not interact with collagen, is not affected by ascorbate. Only the collagen made in the presence of ascorbate was pepsin resistant. EDB overrode the effects of ascorbate on pepsin resistance and proteoglycan accumulation.Type: ApplicationFiled: June 5, 2007Publication date: December 6, 2007Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: Kurt Musselmann, John R. Hassell, Brad Kane, Bridgette Alexandrou
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Patent number: 7304038Abstract: Disclosed is a therapeutic nutritional compound for treating and supporting the immune response in a mammal, particularly a human baby or child, and the treatment method. Additionally, the therapeutic nutritional compound can be used in conjunction with a vaccine or immunization regimen to reduce the potential undesirable effects caused by other components of the vaccine. The therapeutic nutritional compound can include glutathione, selenium, zinc and antioxidants.Type: GrantFiled: September 9, 2005Date of Patent: December 4, 2007Inventor: Julie A. Buckley
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Patent number: 7303771Abstract: The present disclosure relates to the novel nutritional methods and compositions containing essential alfalfa sprouts powder which reduces certain risk factors of cardiovascular disease specifically an individual's C-reactive protein, LDL-cholesterol, homocysteines and triglycerides while increasing an individual's HDL-cholesterol level.Type: GrantFiled: March 15, 2004Date of Patent: December 4, 2007Inventor: Stephen Truesdale Carney
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Publication number: 20070248651Abstract: A vitamin, mineral, herbal, and micronutrient treatment for acne via support of the physiologic processes in the body which cause acne is disclosed. It is a targeted formula, designed specifically to address the causes of acne. This specific, unique formulation preferably in a gummy substrate for ease of administration, to induce a willingness on the part of the target population to take it, and to increase the bioavailability of the active ingredients. Other types of confection or edible vehicle can be used.Type: ApplicationFiled: July 7, 2006Publication date: October 25, 2007Inventors: Ellie Sawits, Peter C. Dea, Laura Tringale
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Patent number: 7285284Abstract: A cosmetic composition for use as scrubbing agent or a mask uses vitamin C particles or crystals in an oil base, whereby the particles are insoluble in the oil so that they remain as suspended scrubbing particles.Type: GrantFiled: March 22, 2002Date of Patent: October 23, 2007Inventor: Stephen C. Kuhnau
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Publication number: 20070231312Abstract: Preeclampsia and intrauterine growth restriction in a pregnant female mammal are prevented or decreased in severity by administering thereto a combination of a vitamin compound containing B1, Folic Acid (or active form 5-Methyl-Tetrahydrofolate i.e.; Metafolin®), B 6 (Pyridoxine or active form Pyridoxine 5-Phosphate P5P), B 12, Ascorbic Acid, Selenium, Zinc, Co-enzyme Q 10 and N-Acytyl Cysteine, Lycopene, optionally in further combination with Melatonin and/or Vitamin E or/and ASA 81 mg both of later, are cyclooxygenase inhibitors, a PGI.sub.2-mimetic, a thromboxane (TXA.sub.2) inhibitor, a compound possessing TXA.sub.2-agonistic and TXA.sub.2-inhibiting properties, a compound possessing TXA.sub.2-antagonistic and PGI.sub.2-mimetic activities, and a TXA.sub.2 antagonist.Type: ApplicationFiled: October 23, 2006Publication date: October 4, 2007Inventors: Michael V. Muench, Lori L. Muench, Steven M. Feld
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Publication number: 20070225360Abstract: An anti-aging composition containing: (a) at least one first active ingredient chosen from phloretin and its derivatives; (b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives; and (c) at least one non-aqueous organic solvent, with the proviso that if the composition contains ascorbic acid, water is present as a co-solvent.Type: ApplicationFiled: March 20, 2007Publication date: September 27, 2007Applicant: L'OREALInventors: Sheldon R. Pinnell, Jan Zielinski, Isabelle Hansenne
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Patent number: 7268139Abstract: The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.Type: GrantFiled: August 29, 2003Date of Patent: September 11, 2007Assignee: Scios, Inc.Inventors: Andrew A. Protter, David Y. Liu, Patrick O'Connor
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Patent number: 7267830Abstract: The present invention provides improved dietary supplements and methods for inhibiting the progression of macular degeneration and promoting healthy vision. The dietary supplements of the invention contain cobeadlets comprising vitamin E and carotenoids in the form of Vitamin A, lutein and/or zeaxanthing. The dietary supplements of the invention further contain Vitamin C, copper and zinc and may also contain such ingredients as rosemary, DHA, other vitamins and minerals.Type: GrantFiled: December 14, 2004Date of Patent: September 11, 2007Assignee: Alcon, Inc.Inventor: John C. Lang
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Publication number: 20070202091Abstract: A nutraceutical composition and method for promoting the rejuvenation of cells in warm-blooded animals including humans employing mitochondrial energy production-inducing agent for inducing the mitochondrial energy production to proceed from a lower energy production state to a higher energy production state and a nutraceutical composition for supporting the metabolic requirements of the increased mitochondrial energy production induced by the mitochondrial energy production-inducing agent.Type: ApplicationFiled: February 27, 2007Publication date: August 30, 2007Inventor: Stephen L. DeFelice
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Patent number: 7262224Abstract: A cosmetic composition is shown for rejuvenating the appearance of skin with reduced or minimal potential for skin irritation, in the form of a lotion or cream which includes as a major component aloe vera as well as vitamins A, B, C, D and E.Type: GrantFiled: February 6, 2003Date of Patent: August 28, 2007Assignee: Hanna Isul Skin Therapy, Inc.Inventor: Myong Hun Chong
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Patent number: 7255882Abstract: Benzodiazepine withdrawal induced anxiety is treated by administration of an enkephalinase inhibitor, and a gamma-aminobutyric acid (“GABA”) precursor, or an endorphin or enkephalin releaser. These components promote restoration of normal neurotransmitter function and are non-addictive. Use of the enkephalinase inhibitor D-phenylalanine, the GABA precursor glutamine, the serotonin precursor 5-HTP, glycine, and taurine, in combination with coenzymatic functionality of folic acid is preferred for activation of ligand-gated Cl? channel in the central nervous system. Food supplement embodiments provide the human body nutritional supplements to intake certain neurotransmitter precursor substrates, thereby enabling patients of all ages to self-regulate their ability to quell perturbations to equilibrium and simultaneously to adverse effects upon normal physiological and psychological functioning attributable to induced anxiety and panic associated with benzodiazepine withdrawal.Type: GrantFiled: October 29, 2004Date of Patent: August 14, 2007Inventors: Albert Howard Bieser, Terry Leo Neher
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Patent number: 7253212Abstract: The present invention relates to a novel retinol derivative and a cosmetic composition comprising the same, in particular, to a novel retinol derivative represented by the formula (I) exhibiting the effects from both L-ascorbic acid and retinol as well as being free from the disadvantages of two compounds such as skin irritation and instability in cosmetic formulation, and a cosmetic composition comprising the retinol derivative.Type: GrantFiled: December 18, 2002Date of Patent: August 7, 2007Assignee: Coreana Cosmetics Co., Ltd.Inventors: Kun-Su Lee, Jee-Hean Jeong, Seung-Ji Lee, Jung-No Lee, Byong-Kee Jo
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Publication number: 20070178058Abstract: Excellent percutaneous absorption of vitamin C is achieved by pre-treating skin with a cationic constituent such as cationic salt or solution thereof prior to application of a vitamin C composition.Type: ApplicationFiled: December 22, 2006Publication date: August 2, 2007Inventors: Jose E. Ramirez, Joseph Faryniarz
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Patent number: 7250445Abstract: A method for treating anorectal disorders, comprising a step of providing a suppository containing between 1000 and 500,000 IU of an antioxidant selected from the group of Vitamin A, Vitamin C, Vitamin E; and a step of placing the suppository within the rectal cavity for a period of time required for dissolution of the suppository.Type: GrantFiled: January 14, 2005Date of Patent: July 31, 2007Inventor: Eli D. Ehrenpreis
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Patent number: 7244749Abstract: The present invention provides compositions and methods for lowering plasma Lp(a) levels in humans. The present invention provides compositions and methods for lowering the risk factors for cardiovascular diseases. Moreover, this invention provides therapeutic alternatives to current pharmaceutical interventions for the lowering of cholesterol, LDL-cholesterol, triglycerides and other metabolic risk factors.Type: GrantFiled: January 26, 2004Date of Patent: July 17, 2007Inventor: Matthias Rath
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Patent number: 7223775Abstract: An ascorbic acid derivative, which is a compound represented by the following general formula (1) or a salt thereof: [Chemical Formula 11] (1)(wherein X and Y each represents H or a protective group for OH, R1 and R2 each represents an alkyl group having from 1 to 19 carbon atoms, which may be linear or branched, and the total number of carbon atoms in R1 R2 is an integer of 5 to 22).Type: GrantFiled: April 11, 2003Date of Patent: May 29, 2007Assignee: Showa Denko K.K.Inventors: Norihito Nishimura, Hiroshi Ishii, Makoto Saito
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Patent number: 7214709Abstract: A mixture obtained by mixing ascorbic acid powder with arginine powder in a weight ratio (ascorbic acid/arginine) of 1/5 to 20, especially 1/5 to 1/4; and a supplement such as a nutrient preparation and a health-care food containing the mixture. Mixing of arginine powder and ascorbic acid powder in the weight ratios eliminates stringent taste specific to arginine and alleviates stringent feeling in the stomach (heartburn, nausea or vomiting) after oral intake thereof. The mixture prevents also peroxidative injuries of cells caused by an administration of a great amount of arginine alone. Further, mixing of arginine powder with ascorbic acid powder prevents browning of the mixture after long-term storage.Type: GrantFiled: November 15, 2002Date of Patent: May 8, 2007Inventors: Eiji Kimoto, Fukumi Morishige
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Patent number: 7208467Abstract: SR-BI is present at relatively high levels on the membranes of hepatocytes and steroidogenic tissues, including the adrenal gland, testes, and ovaries, where it mediates the uptake and transport of cholesteryl ester from high density lipoproteins. It has been demonstrated that transgenic animals which do not produce SR-BI are healthy, with the exception that the females are infertile. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes and are infertile. Surgical, genetic and pharmacologic methods were used to show that the fertility of SR-BI KO females (or their transplanted oocytes) can be restored in the absence of ovarian and/or extraovarian SR-BI expression by manipulations that modify the structure, composition and/or abundance of their abnormal plasma lipoproteins. These manipulations included inactivation of the apolipoprotein A-I gene and administration of the cholesterol-lowering drug PROBUCOL™.Type: GrantFiled: June 7, 2002Date of Patent: April 24, 2007Inventors: Monty Krieger, Helena E. Miettinen
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Patent number: 7205007Abstract: The invention provides a nutritional supplement system and program for patients undergoing or who have undergone a surgical or other invasive or stressful procedure, or who have suffered an injury. This nutritional supplement for the peri-operative period is designed to prevent deficiencies of nutrients needed for optimal health and healing during this period or for general application and to enable the person receiving the nutritional supplementation to achieve maximum healing and rapid recovery from a procedure or injury.Type: GrantFiled: October 4, 2005Date of Patent: April 17, 2007Assignee: Fairfield Clinical Trials, LLCInventor: Edward M. Lane
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Patent number: 7202276Abstract: This invention relates to the regulation of vascular endothelium biocompatibility and to the inhibition of vessel wall cell and other types of cell hyperplasia following vessel wall dysfunction and/or injury. More particularly, the invention relates to the dietetic and pharmaceutical preparations of 13-hydroxyoctadeca-9Z, 11E-dienoic acid (13-HODE) and its use in reducing or inhibiting vessel wall hyperlasia and restoring vessel wall biocompatibility.Type: GrantFiled: April 9, 2001Date of Patent: April 10, 2007Assignee: 1411198 Ontario LimitedInventors: Michael Buchanan, David Horrobin
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Patent number: 7199153Abstract: A formulation is described comprising paracetamol, niflumic acid or a pharmaceutically acceptable salt or ester thereof and a pharmaceutically acceptable excipient.Type: GrantFiled: March 20, 2001Date of Patent: April 3, 2007Assignee: SmithKline Beechman, p.l.c.Inventors: Geoffrey Douglas Clarke, Melanie Jayne Sammons, Mark Wyles
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Patent number: 7189759Abstract: The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.Type: GrantFiled: May 23, 2001Date of Patent: March 13, 2007Assignee: Medicis Pharmaceutical CorporationInventors: Mitchell S. Wortzman, Philip J. Gordon, Eugene H. Gans, Bhiku G. Patel
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Patent number: 7179791Abstract: Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase.Type: GrantFiled: January 11, 2001Date of Patent: February 20, 2007Assignee: Duke UniversityInventors: Jonathan S. Stamler, Limin Liu, Alfred Hausladen, Raphael Nudelman
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Patent number: 7179841Abstract: The present invention relates to ascorbic acid single-phase solution compositions that provide enhanced stability, enhanced solubility and an enhanced photoprotective effect as compared to prior compositions. The compositions comprise L-ascorbic acid; a cinnamic acid derivative such as p-coumaric acid, ferulic acid, caffeic acid, sinapinic acid, a derivative thereof, and a combination thereof; a solvent comprising a glycol ether and an alkanediol; and water; the composition having a pH of no more than about 3.5. The compositions may also comprise a form of Vitamin E and are useful for treatment of radical-induced damage to a subject, particularly the skin of a subject.Type: GrantFiled: January 11, 2005Date of Patent: February 20, 2007Assignee: L'Oreal USA Creative, Inc.Inventors: Jan E. Zielinski, Sheldon R. Pinnell
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Patent number: 7169382Abstract: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7 and/or 5.5 compound into the culture medium of such reconstructed epidermis/skin equivalent and/or topically applying onto the face surface of such reconstructed epidermis/skin equivalent a composition which comprises lipid lamellar vesicles incorporating at least one ceramide 7 and/or 5.5 compound.Type: GrantFiled: January 29, 2004Date of Patent: January 30, 2007Assignee: L'OrealInventors: Mélanie Chopart, Isabelle Castiel, Jean-Thierry Simonnet
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Patent number: 7166309Abstract: The present invention provides for a method of using a nutritional composition in inhibiting smooth muscle cell contraction, and hence lowering hypertension.Type: GrantFiled: May 26, 2004Date of Patent: January 23, 2007Inventors: Vadim Ivanov, Svetlana Ivanova, Wahid M. Roomi, Aleksandra Niedzwiecki, Matthias Rath
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Patent number: 7138146Abstract: The subject of the present invention is acrochordon removal and prevention utilizing safe dependable effective biocompatable treatments with no scarring, bleeding, twisting, yanking, choking, burning, freezing, shocking, screaming and hypo pigmentation or hyper pigmentation. In one aspect of the invention, methods are provided for acrochordon removal comprising application of high concentrations of hydrogen peroxide.Type: GrantFiled: February 8, 2002Date of Patent: November 21, 2006Inventors: Mickey Miller, Margaret Ancira
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Patent number: 7128930Abstract: Methods for treating sexual dysfunction are disclosed. The methods generally comprise the administration of an NO donor and an antioxidant; the active ingredients can be administered topically to the genitals of the patient. The methods allow for localized NO delivery through topical application of the present compounds, while minimizing, if not preventing, damage associated with peroxynitrite formation. Compositions comprising L-arginine, or a derivative thereof and an antioxidant in a pharmaceutical carrier suitable for application to the genitals is also disclosed.Type: GrantFiled: September 1, 2000Date of Patent: October 31, 2006Inventors: Meir S. Sacks, Knox Van Dyke
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Patent number: 7115563Abstract: A composition having a variety of therapeutic and cosmetic uses comprises: (i) a vitamin; (ii) a metal salt that provides metal ions in vivo; and (iii) insulin or a growth hormone. Such a composition is useful for treating, for example, genetic disorders, skin diseases, cancer and viral infections.Type: GrantFiled: May 29, 2003Date of Patent: October 3, 2006Assignees: Insignion Holding Limited, Veritron LimitedInventors: Rafeda M. A. Younis, Karam M. H. Al Sari, Saad M. H. Al Sari, Ahmad M. H. Al Sari
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Patent number: 7109237Abstract: A water-in-oil emulsion containing ascorbic acid and, as an emulsifier, a dimethiconecopolyol or an alkyldimethiconecopolyol, where the aqueous phase having a pH ranging from 5.5 to 7.5. This emulsion allows ascorbic acid to be stabilized and can be used, in particular, in the cosmetics and/or dermatological fields. The invention also relates to a cosmetic process for treating the skin using the emulsion.Type: GrantFiled: August 15, 2002Date of Patent: September 19, 2006Assignee: L'OrealInventors: Isabelle Afriat, Florence Chanvin
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Patent number: 7101578Abstract: The present invention is a salt sorbet facial and body scrub which has enhanced properties to deep clean skin, exfoliate dead skin cells in an efficient manner, and at the same time not damage sensitive skin, especially on a woman's face. It is an object of the present invention to provide an improved facial and body scrub which will provide deep cleaning action to cleanse skin pores in an efficient manner and also to exfoliate skin in an efficient manner. It is a further object of the present invention to provide an improved exfoliating facial and body scrub which although effective for cleaning and exfoliating skin, is not so abrasive as to create any damage to sensitive skin areas, especially on a woman's face. It is a further object of the present invention to provide a cost efficient combination of elements and process for creating an improved facial and body scrub.Type: GrantFiled: March 1, 2004Date of Patent: September 5, 2006Assignee: SPA de Soleil, Inc.Inventor: Jacob Revivo
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Patent number: 7091241Abstract: A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, intravenously, or intraperitoneally. Oral administration may be in the form of capsules containing a predetermined ratio of Vitamin C to Vitamin K3. The supplemental treatment is effective to inhibit metastases of cancer cells and inhibit tumor growth. The ratio of Vitamin C to Vitamin K3 is in the range of about 50 to 1 to about 250 to 1. A method for evaluating the effectiveness of the supplemental treatment includes monitoring the patient's serum DNase activity throughout the course of treatment.Type: GrantFiled: June 3, 2002Date of Patent: August 15, 2006Assignee: Summa Health SystemInventors: Jacques Gilloteaux, Henryk S. Taper, James M Jamison, Jack L. Summers
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Patent number: 7074826Abstract: The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition comprising a compound mentioned above, or a pharmaceutically acceptable salt thereof where salt formation occurs, is administered to the mammal in an amount sufficient to elicit a chemopreventative effect or a chemoprotective effect or a therapeutic effect or a prophylactic effect.Type: GrantFiled: October 3, 2003Date of Patent: July 11, 2006Assignee: Encore Pharmaceuticals, Inc.Inventors: William J. Wechter, Elaine Benaksas Schwartz
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Patent number: 7063865Abstract: A composition that will substantially reduce the deleterious effects of alcohol on the body and substantially reduce the side effects associated with hangovers (i.e. headaches, dizziness, nausea, dry mouth, etc) when taken as recommended. The composition includes an effective amount of (I)-glycine, (I)-glutathione, thiamine, magnesium, selenium, molybdenum. Other vitamins, mineral compounds, flavoring, coloring, and solubility agents may also be added.Type: GrantFiled: May 10, 2002Date of Patent: June 20, 2006Inventors: Jeremy Park Jones, Peter Kevin Dobler
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Patent number: 7048951Abstract: A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline™) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc.).Type: GrantFiled: May 24, 2000Date of Patent: May 23, 2006Assignee: Nioxx, LLCInventors: William A. Seitz, Robert E. Garfield, Alexandru T. Balaban, Randall J. Stewart
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Patent number: 7045546Abstract: Novel derivatives of ascorbic acid and compositions comprising them are provided. The novel derivatives are of the following general formula (I): where R1 is a C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl ; R2 is a group of the following formula (II) wherein R5 or R6 are the same or different and represent hydrogen, a C1–C4 alkyl, or R5 is C1–C4 alkyl group and R6 is a metal cation or ammonium cation; R3 or R4 are the same or different and represent hydrogen, C2–C22 saturated or unsaturated fatty acid residues, amino acid residues, or a C1–C17 alkyl.Type: GrantFiled: July 26, 2001Date of Patent: May 16, 2006Assignee: Tagra Biotechnologies Ltd.Inventors: Vladimir Babtsov, Yury Shapiro, Emma Kvitnitsky, Valery Belakhov
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Patent number: 7045152Abstract: Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N2O3, HNO, and H2S. Optionally, N-acetylcysteine, ascorbate, H2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.Type: GrantFiled: February 14, 2001Date of Patent: May 16, 2006Assignee: Duke UniversityInventor: Jonathan S. Stamler
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Patent number: 7045151Abstract: In a new pharmaceutical combination, the herb, Vitex agnus-castus (chasteberry), enhances hormone balance by increasing progesterone release and, therefore, ovulation frequency. The antioxidants, green tea, vitamin E, and selenium, improve overall reproductive health. L-arginine, an amino acid, stimulates the reproductive organs by improving circulation. Folic acid, vitamins B6 and B12, iron, zinc and magnesium help promote womens' fertility. Sperms are highly susceptible to free radical or oxidative damage from environmental toxicants and natural aging. Vitamins C and E, coenzyme Q10 and selenium are all potent antioxidants that help improve sperm counts and quality. Ferulic acid, an antioxidant found in Dong quai, also improves sperm quality. Zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for hormone metabolism, sperm formation and motility. The amino acid, L-carnitine, promotes formation of healthy sperm.Type: GrantFiled: September 24, 2002Date of Patent: May 16, 2006Assignee: The Daily Wellness CompanyInventor: Aileen Sontag Trant
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Patent number: 7041652Abstract: The present invention relates to novel compositions containing ascorbic acid with an increased bioavailability of this vitamin. These compositions are useful as food supplements possessing preventive properties against damages of human organs, including skin, tissues and cells due to oxidative stress or damages.Type: GrantFiled: August 23, 1999Date of Patent: May 9, 2006Assignee: Merck Patent GmbHInventors: Herwig Buchholz, Jerzy Meduski
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Patent number: 7041699Abstract: A nutrient pharmaceutical formulation composition useful for treating cancer comprising ascorbic acid, L-lysine, L-proline and at least one polyphenol compound selected from the group consisting of epigallocatechin gallate, epicatechin gallate, epigallocatechin, epicatechin, catechin and the use of the composition in treating cancer and other tumors are provided.Type: GrantFiled: January 13, 2003Date of Patent: May 9, 2006Assignee: Matthias RathInventors: Shrirang Netke, Aleksandra Niedzwiecki, Matthias Rath, Waheed M. Roomi
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Patent number: 7037934Abstract: A blood lipid ameliorating composition containing atorvastatin in combination with an agent selected from the group consisting of a riboflavin derivative, a tocopherol compound, an ascorbic acid derivative, pantethine and taurine.Type: GrantFiled: June 11, 2003Date of Patent: May 2, 2006Assignee: Sankyo Company, LimitedInventors: Tsuneki Ohsawa, Ikuo Takagi, Ippei Shimizu, Tatsuhito Kondo, Masato Nakayama, Yasuhiro Torizumi