Ascorbic Acid Or Derivative (e.g., Vitamin C, Etc.) Patents (Class 514/474)
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Publication number: 20100255109Abstract: The present invention provides stabilized antioxidant particles, each of which includes a core consisting of an antioxidant and a first coating layer formed on the surface of the core, wherein the first coating layer is formed by polymerizing at least one ?-lipoic acid or its derivative, a composition including the same, and a method for preparing the same.Type: ApplicationFiled: August 4, 2008Publication date: October 7, 2010Applicant: BIOGENICS, INC.Inventors: Chul Hwan Kim, Chan Jae Shin, So Yeon Seo, Jung Ae Kwon
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Publication number: 20100255117Abstract: The instant invention provides methods and compositions for the treatment of cancer.Type: ApplicationFiled: April 6, 2008Publication date: October 7, 2010Applicant: The Johns Hopkins UniversityInventors: Shyam Biswal, Anju Singh, Deepti Malhotra
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Publication number: 20100255079Abstract: Systems and methods for skin rejuvenation are disclosed herein. In an embodiment, a skin rejuvenation system includes a unit dose of a booster product that includes active ingredients of ferulic acid and phloretin; a unit dose of at least one exfoliating product that includes active ingredients of ferulic acid and phloretin in combination with fruit acids or alpha hydroxyacids; and a unit dose of a nano-additive product for enhancing penetration of the active ingredients. A method for skin rejuvenation includes applying topically, to a skin surface to be treated, a booster product including active ingredients of ferulic acid and phloretin; applying topically, to the skin surface, at least one exfoliating product including active ingredients of ferulic acid and phloretin in combination with one of fruit acids or alpha hydroxyacids; and applying topically, to the skin surface, a nano-additive product for enhancing penetration of the active ingredients.Type: ApplicationFiled: April 2, 2010Publication date: October 7, 2010Inventors: Gabriel Serrano Sanmiguel, Juan Manuel Serrano Nuñez, Joaquin Melendez Zamora
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Publication number: 20100247694Abstract: A composition for topical application to the human external ear canal and nasal membranes for relief from symptoms of inflamation and infections and prophylaxis of sexually transmitted diseases the incoporates L-Ascorbic acid in a concentration of about 2% to about 25% wt/vol., within an acidic range or pH level of about 4.0 to 2.0 pH respectively, in an aqueous solution with a pharmaceutically acceptable liquid carrier. The liquid carrier in alternative exemplary embodiments is pure distilled water or normal 0.9% physiologic saline, pH adjusted in a pre determined composition for the desired therapeutic effect. The liquid carrier in alternative exemplary embodiments is pure distilled water or normal 0.9% physiologic saline, depending upon the preferred degree of absorption and bioavailability to the host tissues of the active ingredients in the novel invention.Type: ApplicationFiled: June 11, 2010Publication date: September 30, 2010Inventor: Joseph Di Bartolomeo
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Publication number: 20100241059Abstract: A device for treating a skin condition is provided. The device comprises a delivery system for administering a composition to the skin disorder. The delivery system includes an electrode for delivering a composition to the skin of a person and a counter electrode. The device also includes a drainage system which includes a channel for removing material from a person's skin and a pump in communication with the channel The device further includes a control system for powering and controlling the electrode system.Type: ApplicationFiled: October 23, 2008Publication date: September 23, 2010Applicant: SKINTREET, LLCInventors: Marina Prushinskaya, Leonid Kaplan
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Publication number: 20100239663Abstract: This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. This invention relates also to food additives and food compositions and packages comprising the composition.Type: ApplicationFiled: May 22, 2007Publication date: September 23, 2010Applicant: BIOHIT OYJInventors: Osmo Suovaniemi, Ville Salaspuro, Martti Marvola, Mikko Salaspuro
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Publication number: 20100234402Abstract: This invention provides methods of treating and abrogating spinal muscular atrophy by administering an antioxidant. Additionally, the invention provides a method of protecting the SMN protein by administering an antioxidant.Type: ApplicationFiled: June 2, 2008Publication date: September 16, 2010Inventors: Gideon Dreyfuss, Lili Wan
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Publication number: 20100234328Abstract: A liquid antimicrobial composition comprising an organic acid and one or more anionic surfactants is disclosed. In one embodiment, the organic acid is lactic acid and the anionic surfactant is sodium octane sulfonate. In a preferred embodiment, the antimicrobial solution is formulated as a teat dip for lactating animals, particularly cows. In other embodiments, the antimicrobial compositions may be used in personal care, hard surface care including hard surface disinfection in households, food processing, hospitals, restaurants, hotels, showers, or topically as hand soaps, surgical scrubs, and hoof disease mitigators.Type: ApplicationFiled: September 10, 2007Publication date: September 16, 2010Applicant: DELAVAL HOLDINGS ABInventors: Fahim U. Ahmed, Alex Skender, Thomas C. Hemling, Camelia N. Traistaru
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Publication number: 20100226982Abstract: The invention relates to a stabilized active ingredient composition comprising at least one carrier material and at least one active ingredient present in stabilized form, and at least one agent for forming the active ingredient from the stabilized form upon addition of an aqueous phase to the composition, wherein the composition is obtained by freeze drying, a process for producing the composition as well as the use of the composition.Type: ApplicationFiled: August 16, 2007Publication date: September 9, 2010Applicant: DR. SUWELACK SKIN & HEALTH CARE AGInventor: Ralf Malessa
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Publication number: 20100226995Abstract: The presently claimed and disclosed inventive concept(s) contemplates a novel polymeric oral dosage form (transmucosal delivery vehicle) for delivery of pharmaceutical and nutriceutical bioactive agents to the mucosa and bloodstream of the intestine. The oral dosage form of the presently claimed and disclosed inventive concept(s) comprises a polymeric coating which encapsulates the bioactive agent and inhibits degradation and dissolution of the bioactive agent within the stomach and within the lumen of the intestine until after passing through the mucosal wall of the small and/or large intestine. The enzymatic degradation of the polymeric delivery vehicle containing the bioactive agent is substantially inhibited until after absorption of the polymeric delivery vehicle into blood vessels of the intestinal mucosa.Type: ApplicationFiled: March 5, 2010Publication date: September 9, 2010Inventor: Daniel R. DeBrouse
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Publication number: 20100227827Abstract: Novel methods of increasing the biosynthesis of aromatic amino acids and compositions containing the precursors of said aromatic amino acids or nicotinamide and methods of use thereof. In addition, methods of monitoring the therapeutic effects of an anti-oxidant therapy by measuring serum protein thiols as a surrogate or predictor of such therapy are disclosed.Type: ApplicationFiled: July 11, 2007Publication date: September 9, 2010Inventor: Ronald W. Pero
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Publication number: 20100215783Abstract: Compositions including synergistic combinations of ascorbic acid, Indian gooseberry, and additional components for increasing the antioxidant capability of certain target components, such as superfruits, fruits, and other low and/or high antioxidant containing substances. Particular combinations of ascorbic acid, Indian gooseberry extract, one or more citrus bioflavanoids, and one or more fatty acids added to various target components synergistically increases the antioxidant capability of the overall composition over expected values.Type: ApplicationFiled: February 23, 2010Publication date: August 26, 2010Applicant: NUTRAGENESIS, LLCInventor: Peter S. McNeary
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Publication number: 20100215754Abstract: A delivery system for various functional compounds is disclosed. The delivery system incorporates a composition containing alumina. Various functional materials containing particular moieties may be adsorbed onto the alumina and used as desired. The functional compounds can be, for instance, pharmaceuticals, xenobiotics, anti-microbial agents, anti-viral agents, UV absorbers, odor control agents, fragrances, and the like. In one particular embodiment, for instance, certain dyes can be adsorbed onto the alumina surfaces. Once the dye is adsorbed onto the alumina surface, the resulting particles can be combined with a liquid vehicle for use in any suitable printing process.Type: ApplicationFiled: February 23, 2010Publication date: August 26, 2010Applicant: KIMBERLY-CLARK WORLDWIDE, INC.Inventors: Jason Lye, John Gavin MacDonald
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Publication number: 20100215713Abstract: The present invention provides for a device comprising a scaffold composition, a bioactive composition and a bio-in-hibiting composition, wherein said bioactive and bio-inhibiting compositions are incorporated into or coated onto said scaffold composition, wherein said scaffold composition temporally supports survival and growth of resident follicles, migration and multiplication of stroma cells and spreading and organization of endothelial cells and new vessels wherein said bioactive composition regulates development of a resident follicle, formation of new blood vessels and chemoattraction and proliferation of stroma cells and wherein the bio-inhibiting composition regulates inhibition of the development of a second resident follicle. The presence of the bio-inhibiting composition within the scaffold is involved in the quiescence of the follicles in the primordial stage, which is important to restore fertility.Type: ApplicationFiled: September 30, 2008Publication date: August 26, 2010Inventors: Marie-Madeleine Dolmans-Van Der Vorst, Christiani Andrade Amorim, Anne Van Langendonckt, Jacques Donnez
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Publication number: 20100210569Abstract: The instant invention constitutes an unique subject matter as a whole which has four individual aspects: (1) a class of chiral, non-racemic, synthetic carnitinoid analog carrier molecules which constitute biocompatible transport compounds not found in nature; (2) a subsequently formed, mitochondria-targeting, coupled antioxidant-carrier complex comprising an antioxidant reversibly attached to and releasable from the synthetic carrier molecule; (3) a method for introducing a biologically active antioxidant into the interior of mitochondria of a living cell for subsequent reaction with such reactive oxygen species may then be present; and (4) a system for delivering a biologically active antioxidant to the interior of mitochondria within a living cell.Type: ApplicationFiled: February 12, 2010Publication date: August 19, 2010Inventor: Kosta Steliou
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Publication number: 20100210718Abstract: A method for ameliorating, reducing, and/or preventing lipotoxicity-induced metabolic dysfunction in at least one cell is disclosed, said method comprising a step of contacting said at least one cell with a therapeutically effective amount of a synergistic anti-lipotoxicity cocktail, said cocktail comprising N-acetylcysteine, ascorbic acid, and resveratrol. Also disclosed is a method for treating at least one lipotoxicity-related metabolic disorder chosen from the group comprising (a) metabolic syndrome; (b) non-alcoholic steatohepatitis; (c) obesity; and (d) coronary heart disease, said method comprising the step of administering to a patient a therapeutically effective amount of an anti-lipotoxicity cocktail, said cocktail comprising N-acetylcysteine, ascorbic acid, and resveratrol. Finally, a composition for treating the effects of lipotoxicity, containing a synergistic combination of N-acetylcysteine, ascorbic acid, and resveratrol is disclosed.Type: ApplicationFiled: December 9, 2009Publication date: August 19, 2010Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.Inventors: Oren TIROSH, Zecharia Madar, Anna Aronis, Erez Ilan
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Publication number: 20100203126Abstract: The present invention relates to a multi-layered vitamin/mineral complex tablet having enhanced stability of ubidecarenone. The present invention is characterized in that ubidecarenone is contained in a first layer, and ingredients decreasing the stability of ubidecarenone are contained in an additional layer separated from the first layer. The method is a convenient process, and the formulation prepared by the method can maintain a high content of ubidecarenone during long-term storage, thereby providing a simultaneous intake of ubidecarenone and nutritional ingredients such as various vitamins.Type: ApplicationFiled: July 11, 2008Publication date: August 12, 2010Inventors: Jong-Woo Park, Jin-Woo Han, Yae-Young Choi
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Publication number: 20100202989Abstract: A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.Type: ApplicationFiled: April 19, 2010Publication date: August 12, 2010Inventors: Bing Wang, Sekhar Bodupalli, Xiangfeng Li, Khalid Mahmood, Wei Zhang, Guy Miller
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Publication number: 20100204204Abstract: Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.Type: ApplicationFiled: June 6, 2008Publication date: August 12, 2010Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: Michael Zaworotko, Heather Clarke, Arora Kapildev, Padmini Kavuru, Roland Douglas Shytle, Twarita Pujari, Lissette Marshall, Tien Teng Ong
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Patent number: 7771752Abstract: An animal feed supplement includes fish meal as a source of omega 3 long chain fatty acids for inclusion in the diet of an animal. The animal feed supplement also includes at least one naturally-occurring antioxidant; at least one synthetic antioxidant; an antibacterial agent; an anti-mold/anti-fungal agent; and an anti-chemical activity agent. The omega 3 long chain fatty acids are provided at a level which maximizes the nutritional value of food produce from the animal, but without taint of the food produce. The feed supplement is greater than 5% of the total dietary intake of the animal.Type: GrantFiled: April 8, 2005Date of Patent: August 10, 2010Assignee: Bartlett Grain Pty. Ltd.Inventors: Brian Bartlett, John Wingate
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Publication number: 20100196454Abstract: Provided herein is a scar dressing formulation comprising a blend of a high molecular weight silicone elastomer crosspolymer and a silicone oil, wherein said silicone elastomer crosspolymer is in a volatile fluid. The formulation has a soft, silky feel without being greasy and dries quickly to form a durable, flexible scar dressing.Type: ApplicationFiled: September 8, 2009Publication date: August 5, 2010Inventor: Brian KELLER
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Publication number: 20100196513Abstract: A composition comprising, per litre of aqueous solution, from 30 to 350 g polyethylene glycol, from 3 to 20 g of an ascorbic acid component selected form the group consisting of ascorbic acid, a salt of ascorbic acid, or a mixture thereof, an alkali metal or alkaline earth metal sulphate, preferably from 1 to 15 g thereof, and optionally one or more electrolytes selected from sodium chloride, potassium chloride, and sodium hydrogen carbonate, and preferably also comprising flavourings, is effective in cleansing the gut in preparation for a endoscopy, especially colonoscopy. It is safer than conventional sodium phosphate-based gut cleansing compositions, and hence can be used for patients who would be at risk with sodium phosphate-based compositions, and is better tolerated than conventional PEG-based compositions, leading to better patient compliance and enabling effective out-patient use.Type: ApplicationFiled: April 5, 2010Publication date: August 5, 2010Applicant: NORGINE BVInventors: Norman Barras, Ian David Cox, Alex Ungar, Marc Halphen
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SPINAL CORD INJURY, INFLAMMATION, AND IMMUNE-DISEASE: LOCAL CONTROLLED RELEASE OF THERAPEUTIC AGENTS
Publication number: 20100196481Abstract: A drug delivery system is provided for treatment of oxidative stress. The drug delivery system can include a therapeutic agent and a matrix. The therapeutic agent can include an antioxidant or steroid. The matrix can include a hydrogel, particle, microparticle, or nanoparticle. A method of treating injury, including peripheral nerve injury or spinal cord injury, is also provided. The method includes injecting the drug delivery system at the site of injury.Type: ApplicationFiled: September 25, 2009Publication date: August 5, 2010Applicant: INVIVO THERAPEUTICS CORPORATIONInventors: Christopher D. Pritchard, Robert S. Langer, Francis M. Reynolds, Eric J. Woodard -
Patent number: 7767215Abstract: A pharmaceutical composition for treatment of skin aging including a pharmaceutically effective amount of estriol; a pharmaceutically effective amount of estradiol; a pharmaceutically effective amount of hyaluronic acid; a pharmaceutically effective amount of green tea extract; and a pharmaceutically acceptable carrier is provided. In some embodiments, the composition further includes ascorbic acid, date palm extract, or a combination thereof. Also disclosed is a method for treating symptoms of skin aging and photoaging by administering a pharmaceutical composition having estriol, estradiol, hyaluronic acid, green tea extract, a pharmaceutically acceptable carrier and optionally, ascorbic acid and date palm extract. A method of promoting urogenital function is likewise provided wherein a pharmaceutical composition having estriol, estradiol, hyaluronic acid, and green tea extract is applied intravaginally.Type: GrantFiled: June 28, 2005Date of Patent: August 3, 2010Assignee: MCKA LLCInventors: Stephanie N. McClellan, Ashton A. Kaidi
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Publication number: 20100190847Abstract: A composition which is adapted for oral consumption and which comprises: (i) a PPAR ligand; such as EPA or DHA (ii) an oestrogen receptor binding agent; such as soy isoflavones (iii) an agent that is involved in the post-translational modification of collagen; such as ascorbic acid and (iv) a carotenoid, wherein the composition is substantially free from added zinc and/or selenium, can provide an anti-ageing effect on skin and may be used to increase collagen synthesis in skin.Type: ApplicationFiled: April 1, 2010Publication date: July 29, 2010Applicant: CONOPCO INC., D/B/A UNILEVERInventors: John CASEY, Gail JENKINS, Julia Sarah ROGERS
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Publication number: 20100189818Abstract: Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder (e.g., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc.) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent (e.g., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc.) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.Type: ApplicationFiled: January 19, 2010Publication date: July 29, 2010Applicant: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterInventor: GUOCHUAN EMIL TSAI
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Publication number: 20100183688Abstract: A microparticle delivery system for an active compound which includes an active compound loaded onto polymeric microparticles, wherein the loaded microparticles are encased by a matrix material comprising about 68% to about 99%, by weight, of the microparticle delivery system. Compositions containing the microparticle delivery system, and methods of manufacturing the microparticle delivery system, also are disclosed.Type: ApplicationFiled: July 23, 2007Publication date: July 22, 2010Applicant: Amcol International CorporationInventors: Limin Liu, Ralph Spindler, Stephen J. Urbanec, Gholam-Reza Vakili-Tahami, Ashoke K. Sengupta, Kevin Cureton
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Patent number: 7758899Abstract: A pharmaceutical composition is provided comprised of a physiologically acceptable source of assimilable copper, a source of salicylic acid or a physiologically acceptable derivative thereof, and vitamin C.Type: GrantFiled: December 3, 2004Date of Patent: July 20, 2010Inventor: John Carter
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Patent number: 7758888Abstract: A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.Type: GrantFiled: October 23, 2001Date of Patent: July 20, 2010Assignee: Sol-Gel Technologies Ltd.Inventors: Noa Lapidot, Shlomo Magdassi, David Avnir, Claudio Rottman, Orit Gans, Alon Seri-Levy
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Patent number: 7754256Abstract: A dietary supplement for dogs is disclosed. The composition is a blend of methyl sulfonyl methane, glucosamine sulfate, chondroitin sulfate, ascorbic acid, phylloquinone, yucca powder and stabilized rice bran. The composition may be added to a variety of meat products for dogs, preferably beef and/or beef by-products.Type: GrantFiled: March 6, 2008Date of Patent: July 13, 2010Inventor: Stan Dennison
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Publication number: 20100172916Abstract: The present invention relates to new substituted hydroxyphenylamine based modulators of hormone and/or pigment levels, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: November 9, 2009Publication date: July 8, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Craig Hodulik, Soon Woo
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Publication number: 20100172875Abstract: The present invention concerns the use of an oil-in-water emulsion where the interior of oil droplets exhibit interfaces, between lipophilic domains and hydrophilic or amphiphilic domains, due to the presence of a lipophilic additive solubilized inside the oil droplets and which is used for delayed release of active elements such that the release of at least one active element, which has a octanol/water partitioning coefficient logP higher than ?1, corresponds to a higher Tmax than the Tmax obtained for the simple reference oil-in-water emulsion where no lipophilic additive is used.Type: ApplicationFiled: May 30, 2008Publication date: July 8, 2010Applicant: NESTEC S.A.Inventors: Van Anh Phan, Nicolas Godinot, Laurent Sagalowicz, Martin Leser, Fabien Robert
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Patent number: 7750052Abstract: The present invention relates to the field of food industry, where it may be used for producing alcoholic products, to pharmacology for producing infusions tinctures and extracts or preparations containing aqueous-alcoholic solutions as pharmaceutically acceptable media and also to cosmetology for producing cosmetic products containing aqueous-alcoholic solutions as cosmetically acceptable media. In the proposed process for preparing an aqueous-alcoholic solution, separation of harmful admixtures takes place due to the preliminary protonation separately of water and alcohol prior to the formation of the aqueous-alcoholic solution, this leading to improvements in the physicochemical and organoleptic characteristics of the final product. The process not only provides the possibility of preparing alcoholic beverages of improved quality, but also to shorten the production cycle in the case of preparing some of them (by as much as two times and more) and, as a consequence, to cut down the product costs.Type: GrantFiled: December 23, 2002Date of Patent: July 6, 2010Assignee: OOO “Naucho-Proizvodstvennoe Obiedinenie” “Opytnaya Vodno-Analitcheskaya Laboratoria”Inventor: Valery Nikolaevich Sorokin
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Patent number: 7749547Abstract: A dietary supplement with Creatine, Taurine and a source of Phosphate. The dietary supplement may further include one or more of Double Fermented Triticum aestivum, Dextrose, Isomalt, Trehalose, D-Mannose, Mulberry extract, Enicostemma littorale Blume, Scoparia dulcis, Tarragon extract, Andrographis paniculata, Chromium, Glutamine and Alpha Lipoic Acid. Administered in the morning or following exercise, the dietary supplement increases Creatine uptake and retention in skeletal muscle, muscle mass and strength, exercise capacity and aids in recovery following exercise as well as supporting the immune system during periods of intense training.Type: GrantFiled: September 14, 2006Date of Patent: July 6, 2010Assignee: New Cell Formulations Ltd.Inventors: Marvin A. Heuer, Kenneth Clement, Shan Chaudhuri, James D. Ramsbottom, Megan K. Thomas
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Publication number: 20100167936Abstract: The invention relates to the use of at least one ascorbic acid derivative for the functionalisation of matrices, and to specific ascorbic acid derivatives and processes for the preparation thereof.Type: ApplicationFiled: June 27, 2007Publication date: July 1, 2010Inventors: Thomas Rudolph, Philipp Buehle, Herwig Buchholz
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Patent number: 7745486Abstract: This invention relates to a composition containing quercetin, vitamin B3, and vitamin C. Also disclosed is a method of using the composition for enhancing physical or mental performance or treating various diseases or disorders.Type: GrantFiled: July 16, 2007Date of Patent: June 29, 2010Assignee: Quercegen Pharma LLCInventor: Thomas Christian Lines
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Patent number: 7745487Abstract: This invention relates to a composition containing quercetin, vitamin B3, vitamin C, and folic acid. Also disclosed is a method of using the composition for enhancing physical or mental performance or treating various diseases or disorders.Type: GrantFiled: July 16, 2007Date of Patent: June 29, 2010Assignee: Quercegen Pharma LLCInventor: Thomas Christian Lines
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Patent number: 7741366Abstract: There is provided a new technology that will allow the formulation of pharmaceutically active organic acid products at relatively high pH during storage. This affords the advantages of avoiding formulation with the acid form of the product, yet when the product is used, the pH will be reduced via a chemical reaction, thus forming the organic acid which is the active form of the product. A by-product of the reaction is a significant increase in temperature, thus adding to the efficacy of the organic acid.Type: GrantFiled: January 24, 2007Date of Patent: June 22, 2010Inventors: Leonard Mackles, William Bess
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Publication number: 20100143289Abstract: Compositions including topical formulations comprising secreted products obtained from the culture medium of human umbilical cord stem cells and particular combinations of components therefrom are provided for treatment of various dermatological conditions, such as adverse consequences of aging, wrinkling, altered pigmentation, altered viscoelasticity, and altered thickness, among others. Methods for using the compositions and topical formulations for treating adverse or undesirable dermatological conditions are also provided, as well as preventing the appearance of undesirable dermatological conditions.Type: ApplicationFiled: December 19, 2007Publication date: June 10, 2010Inventors: Michael Cohen, Jacob Cohen
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Publication number: 20100129477Abstract: A preparation for treating psoriasis vulgaris containing ascorbic acids and salts thereof, tartaric acid and vinegar, water and a carrier. A more potent preparation contains in addition vitamin B2 and several plant extracts.Type: ApplicationFiled: February 6, 2006Publication date: May 27, 2010Inventor: Zvi Ben Moshe
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Publication number: 20100124539Abstract: According to an aspect of the invention, a cosmetic preparation comprises about 1% to about 80% by weight of the finished preparation a first silicone fluid having a kinematic viscosity in the range of about 10,000 centistokes (cs) to about 15,000 cs, about 1% to about 80% by weight of the finished preparation a second silicone fluid having a kinematic viscosity in the range of about 25 cs to about 75 cs, about 1% to about 80% by weight of the finished preparation a third silicone fluid having a kinematic viscosity in the range of about 1 cs to about 10 cs, about 0.25% to about 80% by weight of the finished preparation an ascorbic acid ester, about 0.1% to about 1.0% by weight of the finished preparation hexylresorcinol, optionally about 1% to about 80% by weight of the finished preparation vinyl silicone crosspolymer, optionally about 0.25% to about 10% by weight of the finished preparation a fragrance-providing composition, and optionally about 0.1% to about 1.Type: ApplicationFiled: January 21, 2010Publication date: May 20, 2010Applicant: HANSON MEDICAL, INC.Inventor: Gerald L. Hanson
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Patent number: 7718694Abstract: Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones, ascorbate and/or derivatives thereof capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involve the administration (e.g., orally or via inhalation) of such compositions to a patient afflicted with cystic fibrosis, asthma, and/or another condition responsive to stimulation of chloride transport.Type: GrantFiled: January 30, 2004Date of Patent: May 18, 2010Assignee: Children's Hospital & Research Center at OaklandInventors: Horst Fischer, Beate Illek
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Patent number: 7718643Abstract: The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.Type: GrantFiled: May 26, 2009Date of Patent: May 18, 2010Assignee: Schering CorporationInventor: Wing-Kee Philip Cho
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Patent number: 7714011Abstract: A gelled composition formulated to maintain an active ingredient in association with the nasal membrane for an extended period of time is provided. The gelled composition may be formulated as a decongestant or a sinus discomfort relieving agent. The invention further includes a system and method for applying the gelled composition to the nasal membrane.Type: GrantFiled: September 15, 2003Date of Patent: May 11, 2010Assignee: Zicam, LLCInventors: Tim Clarot, Charles Hensley
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Publication number: 20100113590Abstract: Disclosed is an ADAM inhibitor which enables to prevent or improve conditions caused by increase in ADAM activity. Specifically disclosed is an ascorbic acid derivative represented by the general formula (1) below or a salt thereof. [chemical formula 1] (1), wherein R represents a linear or branched alkyl group having 1 to 22 carbon atoms.Type: ApplicationFiled: December 27, 2007Publication date: May 6, 2010Applicant: Shiseido Company, Ltd.Inventors: Takuya Hiruma, Hirotada Fukunishi, Masaru Suetsugu, Yukiko Matsunaga, Satoshi Amano, Michio Shibata
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Publication number: 20100113578Abstract: The present invention relates to an agent containing L-arginine, 0.2 to 20 parts by weight of L-ascorbic acid per 1 part by weight of L-arginine, and, if desired, at least one selected from the group consisting of ribonucleic acids, ribonucleotides and ribonucleosides. The agent can treat mitochondrial disease which shows a variety of symptoms caused by dysfunction of mitochondria in cells. L-arginine contained in the agent for treating mitochondrial disease of the present invention increases an NO radical level to thereby dilate the arteries. L-ascorbic acid serves to mitigate a harsh taste and acrid feeling accompanied with the intake of L-arginine and eliminate excessive NO radicals.Type: ApplicationFiled: January 11, 2010Publication date: May 6, 2010Applicant: FUMIE MORISHIGEInventor: Fukumi Morishige
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Publication number: 20100111920Abstract: A therapeutic composition for vaginal administration based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generated by the action of an oxidase enzyme on a suitable substrate. Therapeutic compositions according to the present invention are useful for the treatment of vaginal diseases and conditions, including bacterial and fungal infections.Type: ApplicationFiled: September 28, 2007Publication date: May 6, 2010Inventors: Michael Pellico, Rajvinder Kaur Atwal
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Publication number: 20100113587Abstract: The present invention relates generally to the fields of molecular biology and pharmacology. More particularly, it concerns the use of abscissic acid to treat various diseases, including neurodegenerative diseases and neuromuscular diseases.Type: ApplicationFiled: March 6, 2006Publication date: May 6, 2010Inventors: Robert H. Broyles, Robert A. Floyd, Visar Belegu, Austin C. Roth
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Publication number: 20100104635Abstract: The present invention relates to a process for preparing granules of a hydrophilic vitamin with polyvinylpyrrolidone as binder in a fluidized bed granulator, to the granules of a hydrophilic vitamin obtained by said process, to tablets made with said granules of a hydrophilic vitamin, to mixture of L-ascorbic acid for direct tabletting and tablets made with said mixtures.Type: ApplicationFiled: September 14, 2007Publication date: April 29, 2010Inventors: Duane Hoagland, Anisul Quadir, Charles Onyiuke, Frank Tranor, Yoshitomi Kakiguchi, Tomoyoshi Kajiura, Kai Zhuang
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Publication number: 20100099639Abstract: The present invention provides a W/O/W multiple emulsion composition composed of an internal aqueous phase, an oil phase, and an external aqueous phase, the internal aqueous phase containing an ionic physiologically active substance and a physiologically acceptable compound having a molecular weight of 1,000 or less and generating a polyvalent counterion with two or more valencies for the ionic physiologically active substance. The W/O/W emulsion composition of the present invention not only can stably encapsulate a useful substance in its internal aqueous phase at a high encapsulation ratio, but also has high safety.Type: ApplicationFiled: October 26, 2007Publication date: April 22, 2010Applicant: CONTROLLED LIPO TECHS, INC.Inventors: Toshimitsu Terao, Takashi Imagawa, Hironobu Yanagie, Masazumi Eriguchi