Carboxylic Acid, Percarboxylic Acid, Or Salt Thereof (e.g., Peracetic Acid, Etc.) Patents (Class 514/557)
Higher fatty acid or salt thereof (Class 514/558)
Nitrogen other than as nitro or nitroso nonionically bonded (Class 514/561)
Benzene ring nonionically bonded (Class 514/568)
Cyclic carboxylic acid containing three to five carbons or cyclic percarboxylic acid containing three to five carbons or salt thereof (Class 514/572)
Polycarboxylic acid or salt thereof (Class 514/574)
  • MEDICAL USE OF SPLA2 HYDROLYSABLE LIPOSOMES
    Publication number: 20120177726
    Abstract: The present invention relates to medical use of liposomes, more particular the first medical use of sPLA2 hydrolysable liposomes. Such liposomes may be used for targeted delivery of therapeutic agents to cancerous tissue and in such embodiments; the therapeutic agents are typically small molecule antitumor agents. Other aspects of the inventions relates to methods of reducing the side effects of therapeutic agents, e.g. reducing nephrotoxicity, neurotoxicity and gastrointestinal toxicity of a therapeutic agent. Yet another aspect of the present invention relate to methods of prolonging the therapeutic effect of a therapeutic agent.
    Type: Application
    Filed: September 16, 2010
    Publication date: July 12, 2012
    Applicant: Bio-Bedst ApS
    Inventors: Morten Just Petersen, Fredrik Melander, Andres Falk Vikbjerg, Sune Allan Petersonm, Mognes Winkel Madsen
  • Extended release formulation of an antiepileptic agent
    Publication number: 20120178810
    Abstract: The present invention relates to an extended release formulation of an antiepileptic agent. More particularly, the present invention relates to an extended release formulation of divalproex sodium. The present invention also relates to a process for the preparation of extended release formulation of divalproex sodium.
    Type: Application
    Filed: September 10, 2007
    Publication date: July 12, 2012
    Inventors: Tailor Prakash Boya, Haranatha Babu Balanagu, Shailesh Suresh Bhamare, Kishor Dattatray Deo, Sivakumaran Meenakshisunderam
  • METHOD OF USING BETA-HYDROXY-BETA-METHYLBUTYRATE TO REDUCE THE RISK OF INFECTION IN AN ELDERLY INDIVIDUAL
    Publication number: 20120178811
    Abstract: Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of ?-hydroxy-?-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 12, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Debra L. Thomas, Pradip Mukerji
  • HMB uses thereof
    Patent number: 8217077
    Abstract: The present invention relates to methods for the prevention and treatment of chronic inflammatory diseases, cancer, and involuntary weight loss. In the practice of the present invention patients are enterally administered HMB alone or alternatively in combination with eicosapentaenoic (20:5 ?-3), FOS, carnitine and mixtures thereof. HMB may be added to food products comprising a source of amino-nitrogen enriched with large neutral amino acids such as leucine, isoleucine, valine, tyrosine, threonine and phenylalanine and substantially lacking in free amino acids.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: July 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Jeffrey H. Baxter, Pradip Mukerji, Anne C. Voss, Michael J. Tisdale
  • IN SITU GENERATION OF PEROXYCARBOXYLIC ACIDS AT ALKALINE pH, AND METHODS OF USE THEREOF
    Publication number: 20120172440
    Abstract: The present disclosure is related to percarboxylic acid compositions formed in situ in non-equilibrium reactions. The peroxycarboxylic acid compositions are formed using ester based starting materials. Methods for using the percarboxylic acid compositions are also disclosed.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 5, 2012
    Applicant: ECOLAB USA INC.
    Inventors: Junzhong Li, David D. McSherry, Richard Staub
  • Magnesium Compositions and Uses Thereof for Neurological Disorders
    Publication number: 20120171307
    Abstract: A composition for administration to a subject, such as oral administration to a subject, for example, has been provided. Such a composition may comprise at least one magnesium-counter ion compound. A magnesium-counter ion composition described herein may be useful for any of a variety of applications provided herein, such as maintaining, enhancing, and/or improving health, nutrition, and/or another condition of a subject, and/or cognitive, learning, and/or memory function. A magnesium-counter ion composition provided herein may be useful for administration to a subject presenting magnesium deficiency, mild cognitive impairment, Alzheimer's disease, attention deficit hyperactivity disorder, ALS, Parkinson's disease, diabetes, migraine, anxiety disorder, mood disorder, and/or hypertension. A kit, method, and other associated technology are also provided.
    Type: Application
    Filed: February 22, 2012
    Publication date: July 5, 2012
    Applicant: Magceutics, Inc.
    Inventors: Guosong Liu, Fei Mao
  • CONTINUOUS ON-LINE ADJUSTABLE DISINFECTANT/SANITIZER/BLEACH GENERATOR
    Publication number: 20120172437
    Abstract: Methods and systems for on-site, continuous generation of peracid chemistry, namely peroxycarboxylic acids and peroxycarboxylic acid forming compositions, are disclosed. In particular, an adjustable biocide formulator or generator system is designed for on-site generation of peroxycarboxylic acids and peroxycarboxylic acid forming compositions from sugar esters. Methods of using the in situ generated peroxycarboxylic acids and peroxycarboxylic acid forming compositions are also disclosed.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 5, 2012
    Applicant: ECOLAB USA INC.
    Inventors: Paul R. Kraus, Thomas C. Rustad
  • DISPENSER COMPRISING A POLYESTER MEMBRANE FOR CONTROL OF MITES IN BEE HIVES
    Publication number: 20120171268
    Abstract: The present invention is related to a dispenser, which is filled with a gel comprising a C1 to C10 carboxylic acid and a thickener, comprising a polyester membrane. The invention further relates to said gel. It also relates to s method for preparing said dispenser, comprising a) mixing C1 to C10 carboxylic acid and the thickener, and b) filling the mixture of step a) into the dispenser. The invention further relates to a method for the control of mites in bee hives comprising putting said dispenser inside or near a bee hive. It also relates to a use of the dispenser or the gel for the control of mites or of nosema in agricultural, industrial or domestic environment.
    Type: Application
    Filed: September 1, 2010
    Publication date: July 5, 2012
    Applicants: NOD APIARY PRODUCTS LTD., BASF SE
    Inventors: David VanderDussen, Renate Wapenhensch, Markus Gewehr, Marco Candolfi, Roland Becker, Sandrine Leblond, Jean-Marc Petat, Nicole Hanewald, Tobias Huth
  • GENERATION OF PEROXYCARBOXYLIC ACIDS AT ALKALINE pH, AND THEIR USE AS TEXTILE BLEACHING AND ANTIMICROBIAL AGENTS
    Publication number: 20120172439
    Abstract: The present disclosure provides methods for generating percarboxylic acid compositions and/or peroxycarboxylic acid compositions formed external to a point of use in non-equilibrium reactions for use in certain bleaching and antimicrobial applications, in particular laundry applications. The compositions are generated external to a point of use, at alkaline pH levels, viz. greater than about pH 12, and optionally suitable for use with detergents and/or surfactants for synergistic bleaching efficacy. Methods of bleaching and/or disinfecting are further provided.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 5, 2012
    Applicant: Ecolab USA Inc.
    Inventors: Jonathan P. Fast, Robert D.P. Hei, Richard Staub, Thomas J. Dürrschmidt, Peter J. Forth, Junzhong Li, David D. McSherry, Thomas Merz, Johannes G. Winter
  • METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF STATIN-INDUCED MYOPATHY
    Publication number: 20120171286
    Abstract: Disclosed are methods for treating or preventing a statin-mediated myopathy in a subject via administration of a therapeutically effective amount of a geranylgeranylation activator. Further disclosed are kits containing a geranylgeranylation activator useful for the treatment of a statin-mediated myopathy.
    Type: Application
    Filed: April 27, 2010
    Publication date: July 5, 2012
    Applicant: Beth Isreal Deaconess Medical Center
    Inventors: Vikas P. Sukhatme, Stewart H. Lecker, Jun-ichi Hanai
  • GLYCYRRHETINIC ACID ESTER DERIVATIVE SYNTHESIS METHOD AND DEOXOGLYCYRRHETINIC ACID ESTER COMPOUND
    Publication number: 20120172438
    Abstract: A compound represented by formula II, a preparation method, and uses thereof in treating liver damage and inflammation and so on are disclosed. A method for preparing glycyrrhetinic acid derivatives are also disclosed. In the compound represented by formula II, R1 is H, linear or branched C1-C18 alkylformyl, linear or branched C1-C18 alkenylformyl or arylacyl; R2 is linear or branched C1-C18 alkoxy or aryloxy.
    Type: Application
    Filed: May 28, 2010
    Publication date: July 5, 2012
    Inventors: Aiming Zhang, Xiquan Zhang, Chunguang Xia, Hongjiang Xu, Hengqi Wang
  • IN SITU GENERATION OF PEROXYCARBOXYLIC ACIDS AT ALKALINE pH, AND METHODS OF USE THEREOF
    Publication number: 20120172441
    Abstract: The present disclosure is related to percarboxylic acid compositions formed in situ in non-equilibrium reactions. The peroxycarboxylic acid compositions are formed using ester based starting materials. Methods for using the percarboxylic acid compositions are also disclosed.
    Type: Application
    Filed: December 20, 2011
    Publication date: July 5, 2012
    Applicant: ECOLAB USA INC.
    Inventors: Junzhong Li, David D. McSherry, Richard Staub
  • Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells
    Patent number: 8211943
    Abstract: The present invention provides novel methods for treating a pulmonary disease state in mammals by up or down regulating indigenous in vivo levels of an inflammatory agent in mammalian cells comprising contacting the mammalian cells with a therapeutically effective amount of an inflammatory regulator, wherein the inflammatory agent is selected from the group consisting of cytokines, transforming growth factor-?, elastase, and white blood cells, and wherein the inflammatory regulator is selected from the group consisting of pyruvates and pyruvate precursors.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: July 3, 2012
    Inventor: Alain Martin
  • NOVEL PHARMACEUTICAL FORMULATIONS TO PREVENT THE MISUSE OF MEDICINAL DRUGS
    Publication number: 20120164228
    Abstract: Granules having a solid core on which an active ingredient is supported, the core being chosen preferably from among insoluble supports, the granules also having, supported on said the core, the following compounds: one or more colouring agents, one or more metallic pigments, one or more gas-releasing compounds, and optionally one or more embittering agents.
    Type: Application
    Filed: August 11, 2010
    Publication date: June 28, 2012
    Applicant: DEBREGEAS ET ASSOCIES PHARMA
    Inventors: Pascal Suplie, Christophe Lebon
  • STRATEGY FOR ON-SITE IN SITU GENERATION OF OXIDIZING COMPOUNDS AND APPLICATION OF THE OXIDIZING COMPOUND FOR MICROBIAL CONTROL
    Publication number: 20120165407
    Abstract: The invention provides a method of controlling biological fouling of water containing items. The method involves combining at least two reactants, a peroxygen source and an acyl group donor to form peracetic acid. Because the peracetic acid can be made in situ, the entire sum of its short lifespan can be used controlling biocidal fouling and storage and transport is simplified. The invention further facilitates the ease of controlling biocidal fouling by allowing the injection of the biocidal agent in liquid form, in a non-acidic environment, and without the need for any halogen. This allows the inventive biocide to be used with chemistries for which prior art biocides are inapplicable.
    Type: Application
    Filed: December 28, 2010
    Publication date: June 28, 2012
    Inventors: Amit Gupta, Charles J. Reedy, Barbara E. Moriarty, Jeffery M. Atkins
  • COMPOSITION AND METHOD FOR TREATING WOOD-BASED MATERIAL AND WOOD-BASED MATERIAL TREATED WITH COMPOSITION
    Publication number: 20120164239
    Abstract: A composition for treating wood-based material including at least one C1-C7 monocarboxylic acid salt or C1-C7 monocarboxylic acid or a mixture thereof as active agent against deteriation of wood. The composition also includes alkyd emulsion of high unsaturated fatty acid content and/or aluminum ion containing compound in the form of polyaluminum formate in a same aqueous liquid carrier as the C1-C7 monocarboxylic acid salt or C1-C7 monocarboxylic acid or a mixture thereof.
    Type: Application
    Filed: November 25, 2009
    Publication date: June 28, 2012
    Inventors: Juha Estakari, Toivo Mertaniemi, Jari Jussila, Juha Kuusisto, Reijo Saunamäki, Norberto Mancuso
  • Anaplerotic Therapy of Huntington Disease and Other Polyglutamine Diseases
    Publication number: 20120165405
    Abstract: The present invention relates to a method for treating and/or preventing Huntington disease and other polyglutamine diseases, comprising the step of administering an effective amount of a precursor of propionyl-CoA to an individual in need thereof.
    Type: Application
    Filed: December 30, 2011
    Publication date: June 28, 2012
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Alexandra Dürr, Fanny Mochel
  • Perhydrolase providing improved peracid stability
    Patent number: 8206963
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in the ratio of peracetic acid formation to peracetic acid hydrolysis specific activities (PAAF/PAAH ratio). The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: June 26, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Dicosimo, John Edward Gavagan, Mark S. Payne
  • Perhydrolase providing improved specific activity
    Patent number: 8206964
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: June 26, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, John Edward Gavagan, Mark Scott Payne
  • Rejuvenation of reverse osmosis membrane
    Patent number: 8206752
    Abstract: A method for rejuvenating a reverse osmosis (RO) membrane which is subject to biofilm and other contaminants in an aqueous system through the use of a free molecular iodine solution at a pH of about 2.2 to 4.0.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: June 26, 2012
    Assignee: Biomedical Development Corporation
    Inventors: Gregg Siegel, Phyllis Siegel
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156159
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156157
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156155
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156158
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • PERHYDROLASE VARIANT PROVIDING IMPROVED SPECIFIC ACTIVITY
    Publication number: 20120156156
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • Epilepsy treatment employing ketogenic compounds which arrest apoptosis
    Publication number: 20120157392
    Abstract: Method of treating a patient suffering from apoptosis of tissue by administering to the patient a therapeutically effective amount of one or more ketogenic compounds such that a physiological ketosis is produced which arrests the apoptosis.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 21, 2012
    Applicant: BTG INTERNATIONAL LIMITED
    Inventors: KEITH FRANK MARTIN, DAVID JOHN HEAL, ELIZABETH JAGGER
  • COSMETIC USE OF A JASMONIC ACID DERIVATIVE FOR TREATING THE HAIR AND THE SCALP
    Publication number: 20120157527
    Abstract: The present invention relates to the cosmetic use of jasmonic acid derivatives of formula (I) in which: R1 represents a radical COOR3, R3 denoting a hydrogen atom or a C1-C4 alkyl radical, optionally substituted with one or more hydroxyl groups; R2 represents a linear saturated or unsaturated hydrocarbon-based radical containing from 1 to 18 carbon atoms, or a branched or cyclic saturated or unsaturated hydrocarbon-based radical containing from 3 to 18 carbon atoms; and also an optical isomer thereof and/or a corresponding salt thereof, in a composition for caring for and/or making up keratin fibres, in particular human keratin fibres, for the purpose of inducing and/or stimulating the growth of the keratin fibres and/or of halting their loss and/or increasing their density.
    Type: Application
    Filed: July 1, 2010
    Publication date: June 21, 2012
    Applicant: L'OREAL
    Inventors: Christophe Boulle, Maria Dalko
  • FILM COMPRISING ACTIVE DRUGS
    Publication number: 20120148689
    Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of active drugs through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.
    Type: Application
    Filed: February 17, 2012
    Publication date: June 14, 2012
    Inventor: Todd Maibach
  • Antimicrobial Composition and Use as Food Treatment
    Publication number: 20120148716
    Abstract: Antimicrobial compositions are provided comprising a pharmaceutically acceptable organic acid and a pharmaceutically acceptable surfactant. This synergistic combination allows compositions to be formulated at low concentrations that have efficacy in reducing bacterial counts by greater than 3 log within 5 minutes of contact while preserving the organoleptic properties of treated foods, including fresh produce. Also provided are methods for the use of the compositions to reduce the microbial load on the surfaces of foodstuffs, processed food products, and the hard surfaces of food preparation machinery, tools, benches, and the like.
    Type: Application
    Filed: February 1, 2012
    Publication date: June 14, 2012
    Applicant: University of Georgia Research Foundation
    Inventors: Michael P. Doyle, Tong Zhao
  • NEUROPROTECTION FROM BRAIN ANOXIA AND REPERFUSION INJURY DURING STROKE AND COMPOSITIONS OF PKG PATHWAY ACTIVATORS AND METHOD OF USE THEREOF
    Publication number: 20120148560
    Abstract: A pharmaceutical composition for treating or preventing one or both of neural anoxia and reperfusion injury, which includes a pharmacological activator of the PKG pathway, and methods of treating or preventing medical conditions using a pharmacological activator of the PKG pathway.
    Type: Application
    Filed: December 15, 2011
    Publication date: June 14, 2012
    Applicant: Florida Atlantic University
    Inventors: Kenneth DAWSON-SCULLY, Sara Louise Milton
  • Compositions and methods for nutrition supplementation
    Patent number: 8197855
    Abstract: The present invention relates to compositions that may be swallowable, chewable or dissolvable, comprising various vitamins and minerals, and in a specific embodiment comprising vitamin A, beta carotene, B-complex vitamins, vitamin C, vitamin D3, vitamin E, iron, magnesium and zinc, and methods for using these compositions for nutritional supplementation in subjects undergoing physiologically stressful events, such as, for example and without limitation, pregnancy, lactation or any disease state.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: June 12, 2012
    Assignee: Everett Laboratories, Inc.
    Inventors: John A. Giordano, Charles J. Balzer
  • Phenolic antiseptic compositions and methods of use
    Patent number: 8198326
    Abstract: Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including an antiseptic such as halogenated phenols, bisphenols, diphenyl ethers, anilides and derivatives thereof, and combinations thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: June 12, 2012
    Assignee: 3M Innovative Properties Company
    Inventor: Matthew T. Scholz
  • Treatment of Dermatologic Skin Disorders
    Publication number: 20120141576
    Abstract: Retinal and its derivatives are incorporated with liposomes in therapeutic compositions for topical application to prevent or alleviate the conditions and symptoms of cosmetic and dermatologic disorders are described as follows. In particular, retinal and its derivatives are combined with liposomes to increase the penetration of the retinal into the skin, to provide hydration of the skin during treatment, to reduce irritation of the skin during the application of the retinal, for use as a chemical skin peel and other embodiments and uses. The present invention includes utilizing retinol products, and particularly retinal in combination with liposomes each of these embodiments and uses separately as well as in combinations with one another.
    Type: Application
    Filed: March 15, 2007
    Publication date: June 7, 2012
    Inventor: Benjamin Johnson
  • METHODS RELATED TO THE TREATMENT OF NEURODEGENERATIVE AND INFLAMMATORY CONDITIONS
    Publication number: 20120142615
    Abstract: The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 7, 2012
    Applicants: Human Service
    Inventors: Jau-Shyong Hong, Liya Qin, Guorong Li, Michelle Block, Wei Zhang, Po-See Chen, Giia-Shuen Peng
  • Methods and Compounds Regulating the Erythroid Response to Iron Deficiency
    Publication number: 20120142590
    Abstract: The present invention discloses the signaling pathway involved in erythroid repression by iron deficiency. Further disclosed is a non-toxic small-molecule compound which potently reverses the erythroid repression caused by iron deficiency. The present invention further encompasses novel compounds for inhibition of red cell production, useful, for example, in the treatment of polycythemia vera, a malignancy causing uncontrolled red cell production. These inhibitory compounds also promote megakaryocytic lineage commitment and may therefore be useful for augmentation of platelet production. The present invention further discloses isocitrate reversal of iron deprivation.
    Type: Application
    Filed: October 14, 2011
    Publication date: June 7, 2012
    Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Adam N. Goldfarb, Loretta L. Delehanty
  • COMPOUNDS AND METHODS FOR SKIN REPAIR
    Publication number: 20120142684
    Abstract: The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.
    Type: Application
    Filed: November 29, 2011
    Publication date: June 7, 2012
    Applicant: ALLERGAN, INC.
    Inventors: Robert M. Burk, Wha Bin Im, Scott M. Whitcup
  • BROAD SPECTRUM DECONTAMINATE AND DISPERSEMENT SYSTEM
    Publication number: 20120141598
    Abstract: The invention relates to a composition for decontaminating a toxin present in a polar or non-polar matrix. The composition includes (a) at least one activator that generates reactive oxygen species when reacted with an oxygen radical donator, and (b) at least one oxygen radical donator to react with the activator to create reactive oxygen species. The composition may also include one or more oxidizing agents that include reactive oxygen species.
    Type: Application
    Filed: May 22, 2009
    Publication date: June 7, 2012
    Inventor: Jessie Kater
  • OREGANO AND MINT ANTI-INFLAMMATORY COMPOSITIONS AND METHODS
    Publication number: 20120135094
    Abstract: The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and/or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC/MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants.
    Type: Application
    Filed: May 14, 2010
    Publication date: May 31, 2012
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: James E. Simon, Diandian Shen, Hector Rodolfo Juliani, Qingli Wu
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF SICKLE CELL DISEASE
    Publication number: 20120134979
    Abstract: Presented are mechanism based compositions and methods for treatment of SCD and SCD associated symptoms and disorders, particularly increased RBC sickling, HbS polymerization, hemolysis, tissue congestion and disruption and organ damage or failure in a mammal. The disclosed methods feature the identification of the heretofore unknown role of adenosine levels and signaling in the development of SCD and SCD associated symptoms and disorders. This discovery has lead to the identification of compositions for use as therapies for SCD and SCD associated disorders and symptoms in a mammal.
    Type: Application
    Filed: November 22, 2011
    Publication date: May 31, 2012
    Inventors: Yang Xia, Rodney E. Kellems, Yujin Zhang, Harinder S. Juneja
  • NUTRITION WITH LIPIDS AND NON-DIGESTIBLE SACCHARIDES
    Publication number: 20120129935
    Abstract: The invention relates to a liquid nutrition comprising short chain fatty acyl chains and a non-digestible, fermentable saccharide. The composition is particular suitable for use as an infant nutrition. The composition is also suitable for treatment and/or prevention of gut barrier related disorders.
    Type: Application
    Filed: January 30, 2012
    Publication date: May 24, 2012
    Inventors: Gelske SPEELMANS, Martine Sandra ALLES, Jan KNOL
  • WATER AND FEED PRESERVATIVE
    Publication number: 20120128843
    Abstract: Antimicrobial compositions containing buffered propionic or acetic acid mixed with pelargonic acid.
    Type: Application
    Filed: August 3, 2010
    Publication date: May 24, 2012
    Inventors: Kurt Richardson, Julio Pimentel, James D. Wilson
  • SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND WOUNDS, WITH FATTY ACID METABOLISM INHIBITORS AND/OR GLYCOLYTIC INHIBITORS
    Publication number: 20120128724
    Abstract: Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.
    Type: Application
    Filed: November 22, 2011
    Publication date: May 24, 2012
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: M. Karen Newell, Evan Newell, Elizabeth Villalobos-Menuey
  • METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL
    Publication number: 20120121693
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Application
    Filed: December 15, 2011
    Publication date: May 17, 2012
    Inventors: George COTSARELIS, Mayumi Ito
  • 4-HYDROXYBUTYRIC ACID ANALOGS
    Publication number: 20120122952
    Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
    Type: Application
    Filed: April 22, 2010
    Publication date: May 17, 2012
    Inventor: Roger D. Tung
  • METHODS FOR TREATING POLYCYSTIC KIDNEY DISEASE (PKD) OR OTHER CYST FORMING DISEASES
    Publication number: 20120122787
    Abstract: The present invention is directed to, inter alia, methods of treating or ameliorating an effect of a polycystic disease. This method include administering to a patient in need thereof an amount of a modulator of a histone deacetylase (HDAC) path-way, which is sufficient to treat or ameliorate an effect of a polycystic disease, particularly a polycystic kidney disease.
    Type: Application
    Filed: July 9, 2010
    Publication date: May 17, 2012
    Inventor: Rong Li
  • METHOD FOR MAKING A PEROXYCARBOXYLIC ACID
    Publication number: 20120122980
    Abstract: The present invention relates to apparatus and methods for making a peroxycarboxylic acid. The apparatus includes a reaction catalyst and a guard column for pretreating one or more reagents, which can increase the life, activity, and/or safety of the reaction catalyst. The peroxycarboxylic acid compositions made by the method and apparatus can include one or more peroxycarboxylic acids.
    Type: Application
    Filed: November 8, 2011
    Publication date: May 17, 2012
    Applicant: ECOLAB USA INC.
    Inventors: David D. McSherry, Richard K. Staub, Dan N. Tallman, Junzhong Li, Keith E. Lokkesmeo
  • POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF DISEASES RELATED TO CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASE AREAS
    Publication number: 20120122940
    Abstract: The present disclosure relates to lipid compounds of the general formula (I): R1-O—C(R2)(R3)-X??(I) wherein R1 is a C10-C22 alkyl group, a C10-C22 alkenyl group having 1-6 double bonds, or a C10-C22 alkynyl group having 1-6 triple bonds; R2 and R3 are the same or different and may be chosen from different substituents; and X is a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride, a phospholipid, triglyceride, or a carboxamide; or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising at least one compound according to the present disclosure, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic, and inflammatory disease area.
    Type: Application
    Filed: May 7, 2010
    Publication date: May 17, 2012
    Inventors: Ragnar Hovland, Anne Kristin Holmeide, Tore Skjæret, Morten Brændvang
  • VIRICIDAL AND MICROBICIDAL COMPOSITIONS AND USES THEREOF
    Publication number: 20120121679
    Abstract: The present disclosure encompasses compositions comprising a surfactant, and an acid such as, but not limited to, levulinic acid, that together have a synergistic effect in reducing the viability of a virus population compared to the efficacy of the individual compounds. This synergy allows the formulation of compositions where the active agents (including an acid and a surfactant) are present at concentrations effective to inactivate viruses on surfaces, including human skin. The viricidal compositions disclosed herein are efficacious without damaging the surface to which they may be applied, or even altering the organoleptic properties of a treated food substance. The viricidal compositions and wipes containing such compositions are suitable for sanitizing any surface suspected of having a viral load thereon, or where it is desirable to ensure that a viral load is as low as possible.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 17, 2012
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Jennifer L. Cannon, Michael Patrick Doyle, Tong Zhao
  • CONTROL OF ENZYMATIC PERACID GENERATION
    Publication number: 20120122979
    Abstract: A process is provided for producing target concentrations of peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity under conditions where control of reaction pH by selection of buffer concentration and concentration of perhydrolase and reactants produces a targeted concentration of peroxycarboxylic acids. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family 7 (CE-7) based on the conserved structural features. Further, disinfectant formulations comprising the peracids produced by the processes described herein are provided, as are corresponding methods of use.
    Type: Application
    Filed: January 20, 2012
    Publication date: May 17, 2012
    Inventors: Robert DiCosimo, Mark Scott Payne, Eugenia Costa Hann
  • Cosmetic composition and methods of use
    Patent number: 8178113
    Abstract: A cosmetic composition is provided including about 25 wt % to about 55 wt % Aloe vera gel, about 9 wt % to about 33 wt % exfoliant, about 5 wt % to about 20 wt % vitamin C, and about 0.25 wt % to about 1.0 wt % retinyl propionate (vitamin A), wherein said composition has a pH of about 2.0 to about 3.7. Methods of using said composition are also included.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: May 15, 2012
    Inventor: Sheikh Ahmed Abdullah