Carbon To Carbon Unsaturation In R Patents (Class 514/627)
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Publication number: 20120027693Abstract: The methods and compositions of the present invention are directed to the treatment or amelioration of muscle cramps using a composition that includes one or more TRPV1 channel activators, and/or one or more TRPA1 channel activators, and/or one or more ASIC channel activators.Type: ApplicationFiled: July 27, 2011Publication date: February 2, 2012Inventors: Bruce P. Bean, Donald MacKinnon, Roderick MacKinnon
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Publication number: 20120028906Abstract: A method for affecting the timing of cervical ripening and the resultant onset of parturition in a pregnant female mammal, the method comprises administering to a pregnant female one or more than one dose of an agent that chemically mimics innervation of the cervix by the vagus nerve, thereby advancing the onset of parturition, or administering to a pregnant female one or more than one dose of an agent that chemically blocks innervation of the cervix by the vagus nerve, thereby delaying the onset of parturition.Type: ApplicationFiled: March 10, 2010Publication date: February 2, 2012Applicant: LOMA LINDA UNIVERSITYInventor: Steven M. Yellon
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Publication number: 20120022165Abstract: The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-30 fatty alcohol, monoglyceride or the reaction products thereof.Type: ApplicationFiled: September 30, 2011Publication date: January 26, 2012Applicant: MICRODERMIS CORPORATIONInventors: Griscom Bettle, III, William S. Coury
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Publication number: 20120022105Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.Type: ApplicationFiled: October 6, 2011Publication date: January 26, 2012Applicants: Tomlin Scientific, Inc., PiGNX, Inc.Inventors: Richard Numata, Ryan Willey
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Publication number: 20120016032Abstract: Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.Type: ApplicationFiled: March 16, 2010Publication date: January 19, 2012Applicant: Cognis IP Management GmbHInventors: Philippe Moussou, Olga Freis, Louis Danoux, Philippe Grisoni, Laurent Bailly
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Publication number: 20120009240Abstract: The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one therapeutic agent. Methods of forming the multilayer films are also disclosed.Type: ApplicationFiled: June 30, 2011Publication date: January 12, 2012Inventors: Joshua Stopek, Daniel Broom, Amin Elachchabi, Garrett Ebersole
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Publication number: 20110313047Abstract: The present invention is directed to a delivery system capable of solubilizing high concentrations of ceramide, the system containing: (a) at least one C1-C4 monoalcohol; (b) at least one C6-C22 fatty acid and/or alcohol; and (c) from about 5 to about 14% by weight, based on the weight of the composition, of at least one ceramide.Type: ApplicationFiled: May 20, 2011Publication date: December 22, 2011Applicant: L'OREAL S.A.Inventor: Marc CORNELL
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PREVENTION OF BACTERIAL GROWTH AND BIOFILM FORMATION BY LIGANDS THAT ACT ON CANNABINOIDERGIC SYSTEMS
Publication number: 20110301078Abstract: A group of antimicrobial compounds shows effectiveness for preventing bacterial growth and bio film formation. In particular, the compounds are effective for preventing the growth of gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (“MRSA”) bacteria. The compounds include naturally-occurring compounds such as linoleyl ethanolamide, noladin ether, and anandamide, and man-made compounds such as CP55,640 [(?)-cis-3-[2-Hydroxy-4-(l,l-dimethylheptyl)phenyl]-tran s-4-(3-hydroxypropyl)cyclohexanol] and O-2050 [(6aR,10aR)-3-(l-Methanesulfonylamino-4-hexyn-6-yl)-6a, 7,10,1 Oa-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran]. Because these antibacterial compounds have unique modes of action and/or unique chemical scaffolds compared to traditional antibiotics, they are extremely useful against bacteria having resistances to antibiotics.Type: ApplicationFiled: June 25, 2009Publication date: December 8, 2011Inventors: John A. Schetz, Sally A. Hoger -
Publication number: 20110256510Abstract: Disclosed are compositions and methods of using such compositions for inhibiting matrix metalloproteinase activity in dental tissue. The compositions, methods and uses may prevent degradation of the bonding between restorative materials and dental tissues, thereby increasing durability and longevity of the restorative material-dental tissue bonds. For example, the compositions, methods, and uses of the present invention may be used for treating carious dental tissue such as by the creation of dental fillings, crowns, bridges, among other techniques, as well as the creation of esthetic laminate restorations.Type: ApplicationFiled: January 11, 2010Publication date: October 20, 2011Inventors: David Henry Pashley, Franklin Chin-Meng Tay, Milena Cadenaro
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Patent number: 8039670Abstract: There are disclosed compound of formula I, in which R1 represents a hydrophobic moiety adapted to occupy the C? channel of human CDId, R2 represents a hydrophobic moiety adapted to occupy the A? channel of human CDId, such that R1 fills at least at least 30% of the occupied volume of the C? channel compared to the volume occupied by the terminal nC14H29 of the sphingosine chain of ?-galactosylceramide when bound to human CDId and R2 fills at least 30% of the occupied volume of the A? channel compared to the volume occupied by the terminal nC25H51 of the acyl chain of ?-galactosylceramide when bound to human CDId R3 represents hydrogen or OH, Ra and Rb each represent hydrogen and in addition, when R3 represents hydrogen, Ra and Rb together may form a single bond, X represents or —CHA(CHOH)nY or —P(=0)(0?)0CH2(CH0H)mY, in which Y represents CHB1B2, n represents an integer from 1 to 4, m represents 0 or 1, A årepresents hydrogen, one of B1 and B2 represents H, OH or phenyl, and the other represents hydrogen or oType: GrantFiled: October 25, 2006Date of Patent: October 18, 2011Assignees: Ludwig Institute for Cancer Research, Chancellor Master and Scholars of the University of Oxford, The University of BirminghamInventors: Vincenzo Cerundolo, Richard Schmidt, Gopal Reddy, Rengarajan Balamurugan, Gerd Ritter, Gurdyal Besra, Mariolina Salio, Jonathan Silk
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Publication number: 20110251241Abstract: Grease-like compositions are provided for repelling rodents. The compositions utilize nontoxic mineral, synthetic, or vegetable oil based gels containing silica, clay, urea, polytetrafluoroethylene, or metallic soap thickeners and capsaicin.Type: ApplicationFiled: April 7, 2011Publication date: October 13, 2011Applicants: Tomlin Scientific Inc., PiGNX, Inc.Inventors: Richard Numata, Ryan Willey
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Publication number: 20110236460Abstract: Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact with a mesh. The first therapeutic agent may be released at a first rate and the second therapeutic agent may be released at a second rate.Type: ApplicationFiled: March 18, 2011Publication date: September 29, 2011Inventors: Joshua Stopek, Amin Elachchabi, Daniel Broom, Garrett Ebersole
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Publication number: 20110236459Abstract: Surgical implants of the present disclosed include a film comprising a first therapeutic agent and a mesh comprising a second therapeutic agent. The surgical implant includes a film in direct contact with a mesh. The first therapeutic agent may be released at a first rate and the second therapeutic agent may be released at a second rate.Type: ApplicationFiled: March 18, 2011Publication date: September 29, 2011Inventors: Joshua Stopek, Amin Elachchabi, Daniel Broom, Garrett Ebersole
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Publication number: 20110196043Abstract: Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.Type: ApplicationFiled: April 8, 2011Publication date: August 11, 2011Applicant: NeurogesX, Inc.Inventors: Naweed Muhammad, Gene C. Jamieson, Keith R. Bley, Sanjay Chanda
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Publication number: 20110196042Abstract: The invention provides (1) genes differentially expressed in animals administered fatty acid amides that affect one or more of food intake, satiety, lipid metabolism, and fat utilization and (2) compositions and methods relating to the use of the genes to identify new compounds that affect one or more of food intake, satiety, lipid metabolism, and fat utilization.Type: ApplicationFiled: August 10, 2009Publication date: August 11, 2011Inventors: Delphine Tissot-Favre, Frederic Destaillats, Clementine Thabuis, Jean-Charles Martin
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Publication number: 20110189270Abstract: A medical device includes a substrate having at least one surface. The surface has a central portion and a peripheral portion. At least one bioactive agent is disposed over at least a portion of the surface. The medical device having a concentration gradient of the at least one bioactive between the central and peripheral portions.Type: ApplicationFiled: January 10, 2011Publication date: August 4, 2011Applicant: Tyco Healthcare Group LPInventors: Daniel Broom, Joshua Stopek, Amin Elachchabi
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Publication number: 20110182972Abstract: Described here are patches and methods for treating neuropathic pain. In some variations, the neuropathic pain-relieving patch comprises capsaicin or a capsaicin analog, wherein the concentration of the capsaicin or capsaicin analog is less than 1% by weight, and a penetration enhancer, wherein the patch is capable of relieving neuropathic pain over a sustained period of time. The penetration enhancer may be any suitable penetration enhancer. The patches may also include oils, viscosity increasing agents, and the like. In some variations, the pain-relieving patches comprise capsaicin, or an, wherein the concentration of the capsaicin or analog is less than 1%, and a penetration enhancer, whereby delivery of capsaicin from the patch continues for at least an hour, and whereby a single use of the patch provides a therapeutic benefit for at least one month, two months, or three months. Methods for treating neuropathic pain are also described.Type: ApplicationFiled: April 8, 2011Publication date: July 28, 2011Applicant: NeurogesX, Inc.Inventor: Keith R. Bley
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Publication number: 20110184069Abstract: Compositions are provided that contain a TRPV1 agonist, such as capsaicin, and a solvent system. Topical application of the composition results in rapid delivery of agonist to the dermis and epidermis. Method of using the compositions for reducing nociceptive nerve fiber function in subjects, and for treatment of capsaicin-responsive conditions are also provided.Type: ApplicationFiled: April 8, 2011Publication date: July 28, 2011Applicant: NeurogesX, Inc.Inventors: Naweed MUHAMMAD, Gene C. Jamieson, Keith R. Bley, Sanjay Chanda
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Publication number: 20110178151Abstract: The present invention relates to novel fatty acid derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as agents for the treatment of obesity and related disorders, and for improving cognition.Type: ApplicationFiled: March 4, 2009Publication date: July 21, 2011Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWInventors: Jehoshua Katzhendler, Elliot Berry, Yosefa Avraham, Yousef Najajreh, Meir Saidian, Raphael Mevorach
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Publication number: 20110172305Abstract: The present invention relates to a method for promoting infant feeding, growth or development comprising administering to an infant a formula or a pharmaceutical composition comprising an endocannabinoid in an amount sufficient to promote feeding, growth or development. The present invention also relates to an infant formula comprising an enhanced amount of an endocannabinoid. The infant formula of the invention may be in a powder form or in a liquid form. The infant formula or the pharmaceutical composition may further comprise an endocannabinoid-promoting compound.Type: ApplicationFiled: October 2, 2008Publication date: July 14, 2011Inventors: Ester Fride, Ayala Polak-moshe, David Branski, Shimon Ben-Shabat
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Patent number: 7976880Abstract: Pregnane glycoside or a Caralluma extract including the pregnane glycoside of the present invention can be used for medical purposes and as food additives, such as a treatment of obesity, a reduction of blood glucose, a reduction of blood pressure, a reduction in hip, waist and arm circumferences, a reduction of fat, increase of BMR, a decrease of BMI, an increase of lean body mass, an appetite-suppression and a reduction/elimination of joint pain, anti-aging, a treatment for falling sex drive, the treatment for impotency and an erectile dysfunction, and an enhancement of energy levels.Type: GrantFiled: April 26, 2005Date of Patent: July 12, 2011Inventors: Ramaswamy Rajendran, Kamala Rajendran
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Publication number: 20110165198Abstract: The invention provides methods for using fatty acid alkanolamides for reducing lipid absorption from the intestine of an animal. Reducing lipid absorption results in fewer lipids available for an animal to convert to body fat. Converting fewer lipids to body fat means that the animal reduces body fat, body weight, and/or body weight gain when consuming an equivalent amount of lipids without the fatty acid alkanolamides.Type: ApplicationFiled: May 15, 2009Publication date: July 7, 2011Inventors: Delphine Tissot-Favre, Frederic Destaillats, Yuanlong Pan, Fabiola Dionisi, Cristina Cruz-Hernandez, Clementine Thabuis, Jean-Charles Martin
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Publication number: 20110166196Abstract: Provided are methods for treatment and prophylaxis of convulsive disorders and seizures, such as epilepsy and febrile seizures, by modulating TRPV1 channel activation.Type: ApplicationFiled: September 10, 2010Publication date: July 7, 2011Inventors: Julie A. Kauer, Barry W. Connors, Jennifer A. Kim, Helen E. Gibson
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Publication number: 20110135627Abstract: A composition for the relief of pain includes comprising a transducer, a fibrinolytic, at least one of a pain relief agent or an anti-inflammatory agent. The pain relief agent can be capsaicin and the fibrinolytic can be bromelain. The composition can also include at least one of a cooling component, a circulation increasing component, a joint or muscle soothing component and a muscle membrane stabilizer. the cooling agent fcan be menthol. A cream composition can include at least one cetyl esterified fatty acid. A cream can be made by combining the oil with a cream base. Suitable compositions include creams, gels, salves, sprays, powder, balms, liniment, ointments, and transdermal patches A system for pain relief that includes the oil and the cream, or a kit containing a container of the oil and a container of the cream.Type: ApplicationFiled: October 7, 2010Publication date: June 9, 2011Applicant: The Inflasoothe Group, Inc.Inventors: Richard LaMotta, Robert Ornstein, Douglas Redfield, Vijay Vad
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Publication number: 20110118347Abstract: A compound of the formula CH3(CH2)n—RA—(CH2)m-(CH?CH)q—(CH2)p—X wherein RA=(a); q=0 or 1; m and p are independently selected integers of at least 1; n=0 or an integer of at least 1; X is a polar group selected from —CO2RS, where Rs?H, Na, K, —NHRI, —NRIRII or RIII; —CH3OH; —CH3NH2; —CH3NHRI; or —CH3NRIRII; wherein RI, RII and RIII are independently selected from C1-C6 alkyl or an aryl group, preferably a hydrophilically substituted C1-C6 alkyl or aryl group, or RIII is an esterified glycol; and wherein 20>m+n+p+2q?2; is useful for the treatment of ringworm infection caused by Trichophyton tonsurans.Type: ApplicationFiled: May 29, 2009Publication date: May 19, 2011Applicant: Vernolix LimitedInventor: Michael William Fowler
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Publication number: 20110086818Abstract: The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while minimizing effects on non-pain-sensing neurons or other types of cells.Type: ApplicationFiled: March 11, 2009Publication date: April 14, 2011Applicants: Presidents and Fellows of Harvard College, The General Hospital CorporationInventors: Bruce P. Bean, Clifford J. Woolf
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Publication number: 20110077239Abstract: A medicament for the treatment of the phantom phenomena of acute tinnitus and/or phantom pain, a method for the production of such a medicament, and a method for the treatment of such phantom phenomenaType: ApplicationFiled: June 18, 2010Publication date: March 31, 2011Inventors: Marlies Knipper, Lukas Ruettiger, Bernhard Schick, Julia Dlugaiczyk
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Publication number: 20110065627Abstract: This invention describes a topical delivery mechanism that contains a mixture of cetylated fatty esters that act as transdermal carriers of desired therapeutic molecules. The proposed cetyl fatty ester penetrant-complex (Base CFEP-complex) contains specific cetyl fatty esters, polar solvents, a carrier base (gel, cream, lotion, patch or stick gel), antioxidants and the desired pharmaceutical, cosmetic or antigenic response eliciting molecules that are efficaciously delivered by selectively varying component ratios in the complex.Type: ApplicationFiled: October 29, 2009Publication date: March 17, 2011Applicant: CYMBIOTICS INC.Inventors: Raj R. Barathur, Jack Bain Bookout
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Publication number: 20110065801Abstract: The invention relates to the enzymatic synthesis of sphingolipids and compositions comprising sphingolipids from lysosphingolipids and carboxylic esters, and to cosmetic, dermatological or pharmaceutical formulations which comprise these sphingolipids or compositions.Type: ApplicationFiled: May 22, 2009Publication date: March 17, 2011Applicant: EVONIK GOLDSCHMIDT GMBHInventors: Frank Hollmann, Oliver Thum, Pawel Grzebyk, Christoph Toelle
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Publication number: 20110059177Abstract: The invention relates to improved cardioplegia solutions. The invention provides cardioplegia solutions and compositions that produce a readily reversible, rapid electrochemical arrest with minimal tissue ischaemia. The cardioplegia solutions and compositions are used for arresting, protecting and/or preserving organs, in particular the heart during open-heart surgery, transplanting, cardiovascular diagnosis or therapeutic intervention.Type: ApplicationFiled: February 10, 2009Publication date: March 10, 2011Inventor: Hemant Thatte
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Publication number: 20110045073Abstract: The present invention relates to controlled release composition for preventing and/or treating microbial infections in the oral cavity of a subject, said composition comprising a controlled delivery matrix which matrix has releasably associated therewith an amount of between 0.000009 and 5 wt % of a sphingolipid, wherein the composition provides a sphingolipid-release-profile in the oral cavity of a subject, wherein said release-profile is maintained for between 15 seconds and 24 hours and wherein said release-profile provides for a concentration of said sphingolipid in the saliva of said subject of between 20 ?mole/L and 250 ?mole/L.Type: ApplicationFiled: February 19, 2009Publication date: February 24, 2011Applicant: INNOPACT B.V.Inventor: Peter Frank Ekhart
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Patent number: 7888393Abstract: The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-C30 fatty alcohol, monoglyceride or the reaction products thereof.Type: GrantFiled: April 13, 2010Date of Patent: February 15, 2011Assignee: Microdermis CorporationInventor: Griscom Bettle, III
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Publication number: 20110033503Abstract: Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.Type: ApplicationFiled: April 23, 2008Publication date: February 10, 2011Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Patrick J. Sinko, Stanley Stein, Anupa R. Menjoge, Simi Gunaseelan, Siva Naga Sree priay Anumolu, Raghavandra Navath
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Publication number: 20110033525Abstract: Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside rubusoside increased solubility in all tested compounds. The diterpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries. Aqueous solutions by using rubusoside to increase the solubility of otherwise insoluble drugs will have several new routes of administration. In addition, aqueous solutions of therapeutic compounds with rubusoside were shown to retain the known pharmacological activity of the compounds.Type: ApplicationFiled: April 13, 2009Publication date: February 10, 2011Inventor: Zhijun Liu
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Publication number: 20110027326Abstract: An external composition for skin is provided, which gives good warmth without inducing irritation or pain and whose sustainability of warmth is good. The external composition for skin contains (A) an agent for giving warmth and (B) at least one member selected from the group consisting of fatty acid esters of aliphatic polyhydric alcohols and aromatic carboxylic acid esters of lower alcohols or aliphatic polyhydric alcohols.Type: ApplicationFiled: March 26, 2009Publication date: February 3, 2011Applicant: ROHTO PHARMACEUTICAL CO., LTD.Inventor: Yoshiyuki Hirayama
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Publication number: 20110028382Abstract: The invention provides compounds for use in a method of treating oral pharyngeal dysphagia in an individual and related products. One embodiment of the invention comprises administering to an individual an effective amount of a vanilloid receptor 1 (VR-1) agonist or high-affinity partial agonist to promote a swallow reflex.Type: ApplicationFiled: October 7, 2008Publication date: February 3, 2011Inventor: Kevin Burke Miller
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Publication number: 20110014269Abstract: A dermal method of treating chronic post-operative pain with a TRPV-1 receptor modulator. More specifically, a method for treating localized post-incisional neuropathic pain by administering a civamide-containing patch.Type: ApplicationFiled: July 9, 2010Publication date: January 20, 2011Applicant: WINSTON LABORATORIES, INC.Inventor: Joel E. Bernstein
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Publication number: 20100330187Abstract: The invention relates to a food additive that includes, relative to the total weight thereof: about 3.5 wt % of capsicum oleoresin containing 6 wt % of a capsaicine and dihydrocapsaicine mixture; about 5.5 wt % of cinnamaldehyde; about 9.5 wt % of eugenol; the balance up to 100% consisting of hydrogenated vegetable oils. The invention also relates to the uses of said additive for improving the daily distribution of food ingestion by animals, for increasing the amount of water drunk by animals, or for preparing a food product intended for the preventive or therapeutic treatment of animal digestive disorders, such as acidosis or bloating. This food additive is particularly adapted for ruminants such as bovine cattle.Type: ApplicationFiled: January 16, 2009Publication date: December 30, 2010Applicant: PANCOSMA SOCIETE ANONYME POUR L'INDUSTRIE DES PRODUITS BIOCHIMIQUESInventors: David Bravo, Sergio Calsamiglia
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Publication number: 20100322961Abstract: The present invention provides an intranasal drug delivery system containing capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin in the form of oleoresin capsicum used as a carrier to quickly and effectively deliver a drug.Type: ApplicationFiled: August 3, 2010Publication date: December 23, 2010Inventor: Wayne Jeffrey Perry
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Publication number: 20100316742Abstract: A solution and method for treating symptoms commonly associated with fibromyalgia. The solution includes a solvent and a composition including active ingredients of menthol, camphor, and capsaicin, as well as additional components including aloe vera extract, carbomer, decyl polyglucose, deionized water, grapefruit seed extract, green tea extract, orange peel extract, queen of the prairie extract, rose water, silica, sodium, hydroxymethyl glycinate, vegetable glycerin, witch hazel, and yucca extract. The method includes soaking an affected area in the solution for a predetermined period of time.Type: ApplicationFiled: June 15, 2009Publication date: December 16, 2010Inventor: Joe D. Kingsley
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Publication number: 20100316678Abstract: The present invention relates generally to the field of pain management, and in particular, the management of neuropathic pain. The present invention further provides methods and compositions that treat, alleviate, prevent, diminish or otherwise ameliorate the symptoms of neuropathic pain without inducing overt sedation. The present invention also contemplates combination therapy using one or more NK antagonists in combination with one or more compounds which decrease or inhibit neuronal excitation in the treatment of pain in association with the treatment of a particular disease condition or pathology.Type: ApplicationFiled: June 26, 2008Publication date: December 16, 2010Applicant: CNSBio Pty Ltd.Inventor: Colin Stanley Goodchild
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Publication number: 20100303932Abstract: The present invention is a method for attenuating the effects of botulinum toxin poisoning using capsaicin and/or a capsaicin analog.Type: ApplicationFiled: May 27, 2010Publication date: December 2, 2010Inventors: Baskaran Thyagarajan, Joseph J. McArdle
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Publication number: 20100290998Abstract: Methods of inhibiting ischemia-related and ischemia-reperfusion-related injury are provided. Remote administration of a C-fiber activator or TRPV1 agonist or remote electrical stimulation and activation of TRPV1 reduces ischemia-related tissue damage in subjects at risk for ischemia-related tissue damage. In aspects of the invention, remote application of a TRPV1 agonist inhibits ischemia-related cardiac tissue damage. Methods of inhibiting cardiac tissue damage by topically administering the TRPV1 agonist, capsaicin are provided.Type: ApplicationFiled: May 7, 2010Publication date: November 18, 2010Inventors: W. Keith Jones, Xiaoping Ren, Neal Lee Weintraub
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Publication number: 20100291005Abstract: The invention concerns the use of 2E,4E-decadienoic acid-N-isobutylamide (trans-pellitorin) as flavorant, in particular as salivation inducing flavor substance, preferably in a foodstuff or nutrient, an oral hygienic preparation or a gourmet or snack preparation. Further, the invention concerns preparations, semi-finished preparations as well as fragrance, aroma and taste compositions, containing trans-pelletorin as well as a processes for the production of trans-pelletorin.Type: ApplicationFiled: July 6, 2010Publication date: November 18, 2010Applicant: Symrise GmbH & Co. KGInventors: Ian Lucas Gatfield, Jakob Peter Ley, Gerhard Krammer, Heinz-Juergen Bertram, Ilse Loenneker, Arnold Machinek
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Publication number: 20100273887Abstract: The present invention relates to products and mixtures comprising (a) pellitorin and (b) selected cooling agents. The present invention further relates to products and medicaments for soothing irritated oral and/or nasal tissues. The present invention also relates to the use of such mixtures for soothing irritated oral and/or nasal tissues and the use of such mixtures for reducing bitterness, in particular the bitterness of oral care products, confectionery products and medicaments, more specifically reducing the bitterness of menthol and menthol containing products and medicaments.Type: ApplicationFiled: August 16, 2007Publication date: October 28, 2010Applicant: SYMRISE GMBH & CO. KGInventors: Arnold Machinek, Ingo Wöhrle, Jakob Peter Ley, Günter Kindel
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Publication number: 20100267670Abstract: The present invention is directed to novel heterocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.Type: ApplicationFiled: July 6, 2010Publication date: October 21, 2010Inventors: Xuqing Zhang, Xiaojie Li, Zhihua Sui
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Publication number: 20100234379Abstract: The endocannabinoid transporter and FAAH are sites of modulation that allow pharmacological enhancement of protective endocannabinergic signals. Selective inhibitors of the transporter and inhibitors of FAAH caused additive augmentation of endogenous signaling events mediated by the cannabinoid CB1 receptor. Disruption of such signals has been shown to prevent neuronal maintenance processes and increase vulnerability to brain damage. Here, blocking endocannabinoid inactivation enhanced cannabinergic activity and ameliorated cellular disturbances associated with excitotoxicity. Modulating the endocannabinoid system in this way also prevented excitotoxic behavioral abnormalities including memory impairment. Collectively, these results indicate that increasing endocannabinoid responses by inhibiting the endocannabinoid transported and/or the inhibiting FAAH leads to molecular, cellular, and functional protection against excitotoxic insults like stroke and traumatic brain injury.Type: ApplicationFiled: July 28, 2006Publication date: September 16, 2010Inventors: Ben A. Bahr, Alexandros Makriyannis, David A. Karanian
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Publication number: 20100234454Abstract: The present invention relates to the use of vanilloid receptor (VR) antagonists, and more particularly vanilloid receptor 1 (VR1) antagonist, as analgesics in the treatment and/or prohylaxis of cnidaria envenomations.Type: ApplicationFiled: June 11, 2007Publication date: September 16, 2010Applicants: Katholieke Universiteit Leuven K.U. Leuven R&D, University of HawaiiInventors: Eva Cuypers, Evert Karlsson, Jan Tytgat, Angel Yanagihara
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Publication number: 20100234470Abstract: This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.Type: ApplicationFiled: September 14, 2009Publication date: September 16, 2010Applicant: ANESIVA, INC.Inventors: Lakshmi Sangameswaran, Susan Kramer
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Publication number: 20100204313Abstract: The present invention is directed to the treatment of chronic pain that occurs in chronic disease such as chronic pancreatitis by the application, of the drug, resiniferatoxin, to a visceral organ, such as the stomach, which then reduces the pain present in a second visceral organ, such as the pancreas. The reduction of said pain associated with the chronic disease occurs through the drug-induced desensitization of primary pain-sensing neurons that are shared between the two visceral organs. Additionally, application of the drug resiniferatoxin into the first organ, reduces the inflammation that occurs in the second diseased organ. This modulation of shared nerve activity by application of resiniferatoxin, may also be directed to modulate the pain and inflammation in any two visceral organs that share a common spinal or vagal nerve. Finally, application of the drug resiniferatoxin to either the stomach or the jejunum may be used to treat disease and disorders that involve gastroparesis.Type: ApplicationFiled: April 16, 2010Publication date: August 12, 2010Inventor: Pankaj J. Pasricha