Benzene Ring Containing Patents (Class 514/643)
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Patent number: 5244913Abstract: Compositions and methods for dissolving calculi deposits in humans are disclosed. The compositions include solutions of quaternary ammonium salts and are particularly effective for the contact dissolution of pigment portions of biliary tract calculi such as gallstones. The solutions preferably further include mineral chelating agent and disulfide bond cleaving agent to aid in deaggregating mineral components and glycoprotein components of calculi.Type: GrantFiled: November 19, 1991Date of Patent: September 14, 1993Assignee: Baxter International Inc.Inventors: Stephen L. Coulter, Kenneth G. Mayhan, Christy L. H. Oviatt, Steven R. Morehead
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Patent number: 5234817Abstract: A wash solution having a pH of from about 7 to about 12 comprises at least about 0.1 weight percent of one or more cationic surfactants. This wash solution is useful in assays for chlamydial or gonococcal organisms, such as Chlamydia trachomatis or Neisseria gonorrhoeae. In particular, it can be used to remove uncomplexed materials from the insolubilized complexes formed between antigen and antibodies.Type: GrantFiled: June 3, 1991Date of Patent: August 10, 1993Assignee: Eastman Kodak CompanyInventors: Allan D. Pronovost, James H. Gilbert
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Patent number: 5169561Abstract: A defoamer composition including a primary antifoam agent which includes a particulate-type material having a high surface area such as silica, a secondary antifoam agent for acting synergistically with the primary antifoam agent such as polydimethylsiloxane, a water carrier, and a quaternary ammonium salt silane compound which functions as an antimicrobial agent, fixed and adhered to the surface of the particulate material, in order that the defoamer composition be resistant to biological degradation due to the presence in the system of microorganisms. Methods of defoaming cationic, anionic, and nonionic surfactant produced foams are disclosed, as is a method of rendering silica hydrophobic.Type: GrantFiled: April 8, 1991Date of Patent: December 8, 1992Assignee: Dow Corning CorporationInventors: Thomas M. Gentle, William C. White
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Patent number: 5165918Abstract: The invention relates to the use of dodecyl-dimethyl-(2 phenoxyethyl)-ammonium bromide as an antimicrobial agent to be a preservative for ophthalmic drug solutions, in disinfecting solutions, as well as in preservatives for aqueous ocular solutions for contact lenses.Type: GrantFiled: January 5, 1990Date of Patent: November 24, 1992Assignee: Ciba-Geigy CorporationInventors: Barbara L. Heyl, Lynn C. Winterton, Fu-Pao Tsao
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Patent number: 5154920Abstract: Liquid disinfectant compositions are disclosed which can be used to surface-coat substrates with polymeric films which are adherent, water-resistant and which can impart prolonged germicidal properties to the treated surfaces.Type: GrantFiled: October 21, 1987Date of Patent: October 13, 1992Assignee: Ecolab Inc.Inventors: Daniel J. Flesher, Robert T. Hall, Richard C. Chromecek, Michael C. Braun
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Patent number: 5137716Abstract: Described is a method of decreasing the weight in mammals to a desired amount comprising the steps of ingesting an effective weight reducing amount of a cholestyramine for a desired period of time to achieve a desired weight reduction. Compositions useful for reducing weight in patients contain cholestyramine, bran and optionally, artificial sweeteners and flavors.Type: GrantFiled: November 15, 1990Date of Patent: August 11, 1992Inventor: Michael S. Weisenfeld
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Patent number: 5124359Abstract: A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having form one to eight carbon atoms.This sterilant is stable for weeks, is especially useful between pH 4 to 9, and may additionally comprise a chelating agent.Type: GrantFiled: August 27, 1991Date of Patent: June 23, 1992Assignee: Cetylite Industries, Inc.Inventors: Stanley L. Wachman, Sidney Karlan
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Patent number: 5109019Abstract: Antimicrobial mixtures containing quaternary ammonium compounds and iodopropynyloxy ethanol carbamate compounds in a ratio by weight of 0.3:1 to 9:1.Type: GrantFiled: July 6, 1989Date of Patent: April 28, 1992Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Rudolf Lehmann, Hans T. Leinen, Reinhard Orth, Hans-Juergen Mueller
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Patent number: 5102874Abstract: Antimicrobial mixtures contain quaternary ammonium compounds and quaternary phosphonium compounds in a ratio by weight of from 1:9 to 9:1.Type: GrantFiled: August 20, 1990Date of Patent: April 7, 1992Assignee: Ecolab Inc.Inventors: Karl Lintner, Reinhard Orth, Rudolf Lehmann, Hans-Juergen Mueller
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Patent number: 5100920Abstract: A quaternary ammonium salt of the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 represent each ##STR2## or an alkyl group having one to four carbon atoms provided that at least of them is ##STR3## wherein R.sub.5 represents an alkyl or alkenyl group having four to 22 carbon atoms, and R.sub.6 represents an alkyl or alkenyl group having two to 20 carbon atoms; R.sub.3 and R.sub.4 represent each an alkyl group having one to four carbon atoms or --CH.sub.2 CH.sub.2 OH; and X.sup..crclbar. represents a counter anion:is an effective miticide and causes no chemical damage to fruit trees and vegetables.Type: GrantFiled: August 1, 1986Date of Patent: March 31, 1992Assignee: Kao CorporationInventors: Tetsuji Iwasaki, Kazuhiko Kurita
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Patent number: 5093370Abstract: A quaternary ammonium having a muscle relaxation activity compound represented by the formula (I): ##STR1## wherein R.sub.1 represents a methylene, a lower alkylenoxy, a lower alkenylene, a lower alkynylene, --CO--, --COO--, a lower alkylene carbonyloxy, --CH(OR.sub.5)--, a lower alkylenecarbonyl, a hydroxy lower alkylene, --O--, --S--, --SO--, or --SO.sub.2 --; R.sub.2 represents a hydrogen atom, a hydroxy lower alkyl, an aldehyde, a lower alkyl carbonyl, --NO.sub.2, or --NHR.sub.6 ; R.sub.3 represents a hydrogen atom of a group --R.sub.1 --(CH.sub.2).sub.a --[CH(CH.sub.2 A)--CH.sub.2 ].sub.b --A; R.sub.4 represents an anion; R.sub.5 and R.sub.6 represent a hydrogen atom or a acetyl; A represents a quaternary ammonium group; a represents an integer of 1 to 8; b represents 0 or 1; m represents an integer of 1 to 4; and (Z) represents a trivalent benzene ring, a trivalent naphthalene ring, a trivalent diphenyl or a trivalent ethane radical.Type: GrantFiled: April 9, 1990Date of Patent: March 3, 1992Assignee: Tobishi Yakuhin Kogyo Kabushiki KaishaInventors: Masayasu Kimura, Kenji Naito, Osamu Sakuma, Tadashi Morita
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Patent number: 5049383Abstract: Use of fine-particled biocidal aqueous cationic dispersions of polymers as biocidal treatment agents for substrates at risk from microbes, preferably for fungicidal, bactericidal and/or algicidal treatments. The dispersions of polymers used are biocidal cationic dispersions of polymers which can be obtained from suitable monomers by emulsion polymerization and which contain biocidal cationically surfactant quaternary organic ammonium compounds, preferably tetra-substituted ammonium compounds of the formula (I) and/or alkyl- or alkenylpyridinium compounds of the formula (II), in particular in an amount of 0.1 to 20% by weight, based on the disperse polymer. The average particle diameter of the polymer particles in the biocidal cationic dispersions of polymers is preferably 0.02 to 0.5 .mu.m at a cationic activity of 1.5 to 600 .mu.mol per g of solid, measured at pH 7, and the solids content of the dispersions is preferably 3 to 40% by weight.Type: GrantFiled: December 29, 1989Date of Patent: September 17, 1991Assignee: Hoechst AGInventors: Hans-Ullrich Huth, Helmut Braun, Franz Konig
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Patent number: 5039688Abstract: Quaternary ammonium salts such as the benzalkonium chlorides and cetylpyridinium chloride can prevent the transmission of AIDS-causing virus through blood transfusions and through the use of blood products prepared using the blood of an AIDS infected individual.Type: GrantFiled: April 14, 1989Date of Patent: August 13, 1991Assignee: Merrell Dow Pharmaceuticals, Inc.Inventor: Peter J. Lewis
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Patent number: 5036106Abstract: Methods are described to utilize synergistic interactions by various combinations of (1) bethanidine and various tricyclic compounds, (2) bethanidine and bretylium tosylate, (3) bretylium tosylate and various tricyclic compounds, and (4) debrisoquin sulfate and various tricyclic compounds, preferably in a single injectable or oral dosage form, to prevent, treat, and reduce the vulnerability of the heart to ventricular fibrillation and other ventricular arrhythmias in animals, both human and otherwise. Also, the use of bethanidine and bretylium tosylate in combination, and the use of debrisoquin sulfate for the resuscitation of pulseless beings, the use of debrisoquin sulfate for the suppression of ventricular fibrillation and ventricular tachycardia, and the use of bethanidine as an antidote to tricyclic antidepressant toxicity are disclosed.Type: GrantFiled: September 5, 1989Date of Patent: July 30, 1991Inventor: Marvin B. Bacaner
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Patent number: 5030659Abstract: Liquid, aqueous disinfectant preparations containing a combination of(a) at least one microbicidal quaternary ammonium compound(b) at least one microbicidal biguanide compound and(c) at least one microbicidal phenolic compound,components (a) and (b) being present in a ratio by weight a:b of (16 - 2); 1 while components (a) and (c) are present in a ratio by weight a:c of (16 - 2):1.Type: GrantFiled: February 8, 1990Date of Patent: July 9, 1991Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Klaus Bansemir, Karlheinz Disch, Klaus Hachmann
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Patent number: 5026561Abstract: The invention relates to a method for inhibiting or destroying unicellular living organisms of a human or animal. The method comprises contacting the unicellular living organisms with the composition which comprises at least one quaternary ammonium salt and which may further comprises a metal fluoride for example, lithium fluoride. A preservative, such as Kathon (Registered Trademark) may also be present in the composition. The method is useful in inhibiting or destroying unicellular living organisms such as viruses or retroviruses, fungi, bacteria, or organisms which cause sexually transmittable diseases. The method may also be used to inhibit or destroy spermatozoa, or inhibit pathogenic microorganisms.Type: GrantFiled: September 20, 1988Date of Patent: June 25, 1991Assignee: Atlantic Pharmaceutical Products LimitedInventors: Pierre Bourbon, Pierre Lagny, Pierre Billot
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Patent number: 5019567Abstract: A pharmaceutical or cosmetic composition for topical application comprises, in a physiologically acceptable support, the combination of benzoyl peroxide and at least one quaternary ammonium lipophilic salicylate having general formula (I): ##STR1## where: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be identical or different, representing a substituted or interrupted alkyl or cycloalkyl radical;(ii) R.sub.3 and/or R.sub.4 represent(s) the group:R.sub.8 --OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pwhere O.ltoreq.n.ltoreq.4 and p is 0 or 1; R.sub.8 represents H or an alkyl, alkenyl, alkylcycloalkyl or alkylanyl radical;(iii) R.sub.4 represents an alkylenephenyl radical;(iv), (v): R.sub.1 and R.sub.2 may form an aromatic or nonaromatic saturated or unsaturated heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 together with nitrogen, may form polycyclic derivatives; and R.sub.5 represents a group having the formula: ##STR2## where n may vary from 0 to 10.Type: GrantFiled: November 23, 1988Date of Patent: May 28, 1991Assignee: L'OrealInventors: Michel Philippe, Michel Hocquaux, Henri Sebag, Irina Beck, Jean P. Laugier
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Patent number: 5017617Abstract: A disinfectant composition for medical use is provided that has satisfactory bactericidal effects, and that rarely causes skin damage even when used frequently. The composition comprises ethanol used for disinfection, a bactericidal agent, and an emollient, wherein said bactericidal agent is at least one selected from the group consisting of chlorhexidine digluconate, alkylpyridinium salts, and quaternary ammonium salts, and said emollient is at least one selected from the group consisting of diesters of dibasic acid, triesters of citric acid, triesters of phosphoric acid, polyoxyethylene glyceride of higher fatty acid, and polyglycerol.Type: GrantFiled: March 13, 1989Date of Patent: May 21, 1991Assignee: Saraya Kabushiki KaishaInventors: Koji Kihara, Taro Furuta
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Patent number: 5017612Abstract: A composition capable of preserving moisture-containing agriculture products succeptible to mold spoilage from mold spoilage for an extended period of time comprising a mold-inhibiting agent, a quaternary ammonium compound, and a polyglycol and the method of preserving agricultural products utilizing the composition.Type: GrantFiled: March 23, 1987Date of Patent: May 21, 1991Inventor: James E. Nayfa
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Patent number: 4994199Abstract: Novel nonionic antimicrobial amine glycidol compounds which may be used in cleaning compositions with anionics, nonionics or cationic surfactants as cleaning agents or a preservative in water-based functional fluids or surface coating compositions are represented by the formula: ##STR1## wherein R is an alkyl group having from about 8 to about 18 carbon atoms, and mixtures thereof, R.sub.1 is selected from the group consisting of benzyl or an alkyl group having from 1 to about 12 carbon atoms, X is Cl, Br, or I, and n and m are from 1 to about 6.Type: GrantFiled: April 16, 1990Date of Patent: February 19, 1991Assignee: Olin CorporationInventors: Michael Scardera, Frank R. Grosser
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Patent number: 4983635Abstract: A fortified quaternary ammonium compound with dual synergistic phenols is provided for disinfection and sanitization. This formula consists of dual chain quaternary ammonium (N-alkyldimethylethylbenzyl ammonium chloride N-alkyldimethylbenzyl ammonium chloride), ortho phenyl phenol, paratertiary amyl phenol, isopropyl alcohol, citric acid, and water in the following gram proportions 47.70, 0.80, 0.80, 10.00, 0.40, 40.30, to give 100.00 grams total. This formula is the concentrated formulation and can be diluted for use in the health professions, consumers area, and agricultural area. The variant is decreased in the quaternary ammonium concentration from the concentrate of 25% to a low of 0.5%, all other compounds remain the same.Type: GrantFiled: September 12, 1988Date of Patent: January 8, 1991Inventor: Howard Martin
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Patent number: 4978685Abstract: Water soluble liquid quaternary ammonium polyhalides and quatenrary ammonium polyhalides in water soluble admixture with surfactants, and their use in the control of biofouling in aqueous systems.Type: GrantFiled: May 18, 1989Date of Patent: December 18, 1990Assignee: Great Lakes Chemical CorporationInventors: James E. Gannon, Scott Thornburgh
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Patent number: 4952398Abstract: The present invention is directed to an improved chemical composition for the treatment of water which is particularly adapted to provide increased biocide activity. By biocide is meant in particular an algacide, a bacetericide and a fungicide. The composition is also suitable for the disinfection of animal breeding places an the cleansing of soil.Type: GrantFiled: March 17, 1988Date of Patent: August 28, 1990Inventor: Jean Tapin
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Patent number: 4950685Abstract: A synergistic wood preservative composition is provided comprising a quaternary ammonium compound and 3-iodo-2-propynyl butyl carbamate having the properties of providing stain resistance to wood. The quaternary ammonium compound is preferably selected from the group consisting of didecyldimethyl ammonium chloride, tri-methyl-coco-ammonium chloride and dimethyl-di-coco-ammonium chloride.Type: GrantFiled: August 23, 1989Date of Patent: August 21, 1990Assignee: Kop-Coat, Inc.Inventor: Hans A. Ward
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Patent number: 4929644Abstract: A thickened organic composition containing a first organophilic clay which will increase the viscosity of the composition and a second organophilic clay which is different from the first and which will impart biocidal activity to the composition. The second organophilic clay is the reaction product of a smectite-type clay and an organic cation having a benzyl group and a long chain alkyl group. The first and second organophilic clays can be mixed into the organic composition as an additive and may be prepared by using a mixture of cations.Type: GrantFiled: October 24, 1986Date of Patent: May 29, 1990Assignee: Rheox, Inc.Inventor: Ronald D. Guilbeaux
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Patent number: 4923899Abstract: A novel, biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium salt, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having from one to eight atoms.Optionally, a chelating agent and an inorganic nitrite salt may be employed. This sterilant kills bacteria, spores, fungi, and viruses over a pH range from about pH 4 to about pH 9.Type: GrantFiled: June 23, 1988Date of Patent: May 8, 1990Assignee: Cetylite Industries, Inc.Inventors: Stanley L. Wachman, Sidney Karlan
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Patent number: 4918108Abstract: An antibacterial substance which does not have optimum absorbability and is administered parentally into tissue, is administered to a host in conjunction with a benzylamine derivative of the formula ##STR1## wherein R.sub.1 is hydroxyl in the 2- or 4-position or amino in the 2-position;R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; andR.sub.3 is cyclohexyl optionally substituted by hydroxyl;or a non-toxic, pharmacologically acceptable acid addition salt thereof, to improve the absorption of the parenterally administered antibacterial substance.Type: GrantFiled: June 29, 1987Date of Patent: April 17, 1990Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Otto Kern, Franz Wilhelm, Ernst Salamon
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Patent number: 4914132Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of 2-(decylthio)ethanamine hydrochloride and n-alkyl dimethyl benzyl ammonium chloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: May 25, 1989Date of Patent: April 3, 1990Assignee: Betz Laboratories, Inc.Inventors: Deborah K. Donofrio, Wilson K. Whitekettle
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Patent number: 4904698Abstract: A non-irritating liquid cleansing composition is described for cleansing eyelids. The composition includes an aqueous solution of Miranol MS-2 present in a concentration of 7-10%; PEG-15 tallow polyamine present in a concentration of 0.1-0.5%; sodium chloride present in a concentration of 0.6-0.9%; at least one microbiological preservative selected from the group consisting of Quaternium-15 and benzyl alcohol present in a concentration of 0.1-0.5%; and as an optional ingredient disodium EDTA present in a concentration of up to 0.1%. The composition is non-irritating to the eyes, has a pH of between 8.0 and 8.5, and a viscosity very similar to water.Type: GrantFiled: February 11, 1988Date of Patent: February 27, 1990Assignee: OcuSoft Inc.Inventors: Nat G. Adkins, Jr., Douglas S. Rooney
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Patent number: 4902720Abstract: A method for preventing or treating infection or disease in a mammal caused by a virus, such as herpes simplex virus type 1 and 2. A quaternary ammonium compound, such as tetraethylammonium ion or hexamethonium ion, is administered to the mammal in an effective dosage.Type: GrantFiled: July 5, 1988Date of Patent: February 20, 1990Inventor: Joseph A. Baldone
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Patent number: 4898888Abstract: A method for preventing or treating infection or disease in a mammal caused by a virus, such as herpes simplex virus type 1 and 2. A ganglionic blocking agent, such as tetraethylammonium ion or hexamethonium ion, is administered to the mammal in an effective dosage.Type: GrantFiled: October 5, 1988Date of Patent: February 6, 1990Inventor: Joseph A. Baldone
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Patent number: 4871550Abstract: A unique, chemically-defined nutrient composition is disclosed which can enable stressed, catabolic, marathon athletes to achieve superior performance. The diet provides substantially all of the essential nutrients along with flavoring aids in simple, readily available form and comprises free amino acids, vitamins, minerals and trace elements, electrolytes, simple and complex carbohydrates, and flavoring aids. This diet benefits athletes because it provides for substantially all of the nutritional requirements, allows for reproducibility and user familiarity through precise chemical definition, supplies optimal nutritional requirements during training and competition through unique tailoring to the nutritional requirements of an individual athlete, requires minimal digestive energy, and encourages maximal absorption of nutrients. A specific mixture of amino acids, carbohydrates, and flavoring aids is used to achieve superior taste.Type: GrantFiled: September 5, 1986Date of Patent: October 3, 1989Inventor: Phillip L. Millman
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Patent number: 4857209Abstract: A method of controlling the fouling potential of macroinvertebrates, such as mollusks, in aqueous systems which comprises adding to the system an effective controlling amount of a water-soluble quaternary ammonium salt having the following structure: ##STR1## wherein R.sub.1 is an alkyl group having about 6 to 24 carbons; R.sub.2 is an alkyl, aryl or arylalkyl group having about 6 to 24 carbons; R.sub.3 and R.sub.4 are alkyl groups having about 1 to 4 carbons; and X is chloride, bromide, sulfate, bisulfate, nitrate or acetate. Preferably, the quaternary ammonium salt is water-soluble alkyl dimethyl benzyl ammonium chloride having an alkyl chain length from C.sub.6 to C.sub.24 and, most preferably, it has an alkyl distribution of about 40% C.sub.12, 50% C.sub.14 and 10% C.sub.16.Type: GrantFiled: January 13, 1988Date of Patent: August 15, 1989Assignee: Betz Laboratories, Inc.Inventors: Larry A. Lyons, Dwight P. Davis, Paul Swered
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Patent number: 4835143Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of n-alkyl dimethyl benzyl ammonium chloride and tetraalkyl phosphonium halide. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: September 12, 1988Date of Patent: May 30, 1989Assignee: Betz Laboratories, Inc.Inventors: Deborah K. Donofrio, Wilson K. Whitekettle
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Patent number: 4824484Abstract: The present invention relates to a wood preservative comprising either(1) at least one of (a) ammonium monofluorophosphate and/or diammonium monofluorophosphate of the general formula (R.sub.1 R.sub.2 R.sub.3 R.sub.4 N)R.sub.5 PO.sub.3 F in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are identical or different and each denotes a straight-chain, branched or cyclic, saturated or unsaturated alkyl, aralkyl, alkyaryl or aryl radical, either unsubstituted or substituted by an alkyl, alkoxy or a hydroxyl group, up to three of the four R.sub.1 -R.sub.4 can be hydrogen or can together form an alkylene bridge, R.sub.5 is a hydrogen atom or a R.sub.6 R.sub.7 R.sub.8 R.sub.9 N group in which R.sub.6, R.sub.7, R.sub.8 and R.sub.9, respectively, have the same meanings as R.sub.1, R.sub.2, R.sub.3 and R.sub.4, respectively, and (b) a mixture of a salt of monofluorophosphoric acid and at least one ammonium salts of the general formula R.sub.1 R.sub.2 R.sub.3 R.sub.Type: GrantFiled: April 28, 1988Date of Patent: April 25, 1989Assignee: Desowag Materialschutz GmbHInventors: Wolfgang Metzner, Detlef Seepe
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Patent number: 4824867Abstract: Quaternary ammonium compounds have the formula R.sup.1 R.sup.2 R.sup.3 N.sup.+ (CH.sub.2).sub.m Y X.sup.- wherein R.sup.1 is an alkyl containing 8-20 carbon atoms, R.sup.2 is an alkyl containing 8-20 carbon atoms or methyl or ethyl, R.sup.3 is methyl or ethyl, m is an integer from 1-6, X is an anion and Y is a group having the structure --Z, --OH, --OR.sup.4, --OC(O)R.sup.5, --CN, --O--S(O) (O)--OQ, --C(O)OR.sup.6, --C.dbd.CH, --SR.sup.7, --S(O)(O)R.sup.8, --S(O)R.sup.9, --NR.sup.10 R.sup.11 and --CH.dbd.CH.sub.2 wherein R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11 are alkyls containing 1-12 carbon atoms or are phenyl and Z is halogen and Q is hydrogen or a cation having been found to be very effective bactericides.Type: GrantFiled: September 22, 1986Date of Patent: April 25, 1989Inventors: Kim R. Smith, James E. Borland, Joe D. Sauer
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Patent number: 4820737Abstract: Ophthalmic compositions useful as tear stimulants when topically applied to the eye for effective treatment of dry eye syndrome.Type: GrantFiled: March 16, 1988Date of Patent: April 11, 1989Assignee: University of Iowa Research FoundationInventors: Ronald D. Schoenwald, Charles F. Barfknecht
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Patent number: 4818524Abstract: The invention provides an odor neutralizing composition comprising:(a) a complexing agent selected from a polymer of the formula (1) ##STR1## in which R is a substituted or unsubstituted alkylene group having up to 12 carbon atoms in the unsubstituted chain.(b) a carrier capable of assisting wetting of odor forming compositions; and(c) a cationic moiety; said moiety being part of a chemically independent compound, or chemically associated with a complexing agent or the carrier.Type: GrantFiled: July 8, 1987Date of Patent: April 4, 1989Assignee: Walex Products CompanyInventor: Anthony Gibbs
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Patent number: 4804492Abstract: Liquid sanitizing and cleaning compositions with diminished skin irritancy comprise a nonionic surfactant and a di-(lower-alkyl)-long-chain-alkylbenzylammonium benzoate or a di-(lower-alkyl)-di-(long-chain-alkyl)-ammonium benzoate, the latter being produced either by ion exchange of the corresponding quaternary ammonium halide with benzoate or by mixing the quaternary ammonium halide with at least about one molar equivalent of an alkali metal benzoate, in water.Type: GrantFiled: December 16, 1987Date of Patent: February 14, 1989Assignee: Sterling Drug Inc.Inventor: Ernest Bernarducci
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Patent number: 4800235Abstract: The invention is a synergistic biocide comprising a blend of 1,5-pentanedial and a mixture of N-alkyl dimethyl benzyl ammonium chloride and N-dialkyl methyl benzyl ammonium chloride.Type: GrantFiled: June 13, 1986Date of Patent: January 24, 1989Assignee: Nalco Chemical CompanyInventors: Thomas M. La Marre, Cynthia H. Martin
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Patent number: 4797420Abstract: A formulation effective against microorganisms including herpes simplex types 1 and 2 viruses, comprising an alkyl (58% C.sub.14, 28% C.sub.16, 14% C.sub.12) dimethyl benzyl ammonium chloride.Type: GrantFiled: March 13, 1987Date of Patent: January 10, 1989Assignee: Jabco Manufacturing, Inc.Inventor: James A. Bryant
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Patent number: 4778813Abstract: Novel capped polymeric quaternary ammonium compositions formed by reacting ionene type polymers with tertiary amines are useful as microbicides, corrosion inhibitors, debonding agents, flocculants, softeners, and demulsifiers.Type: GrantFiled: January 30, 1985Date of Patent: October 18, 1988Assignee: Buckman Laboratories International, Inc.Inventors: Joseph G. Fenyes, John D. Pera
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Patent number: 4752318Abstract: Special quaternary ammonium compounds are suitable for controlling bacteria, algae and other micro-organisms in cooling water circulation systems, swimming pools and industrial water tanks.Type: GrantFiled: May 22, 1986Date of Patent: June 21, 1988Assignee: Ciba-Geigy CorporationInventors: Joachim Lorenz, Reinhardt Grade
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Patent number: 4745132Abstract: Bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of n-alkyl dimethyl benzyl ammonium chloride and n-dodecylguanidine or water soluble salt thereof. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: July 31, 1986Date of Patent: May 17, 1988Assignee: Betz Laboratories, Inc.Inventors: Paul Swered, Deborah K. Donofrio
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Patent number: 4735969Abstract: A novel bisulfite adduct of menadione, the menadione choline bisulfite adduct, a process for its preparation, and its use as an antihemorrhagic agent.Type: GrantFiled: November 18, 1985Date of Patent: April 5, 1988Assignee: BASF AktiengesellschaftInventors: Joachim U. Schneider, Hans Kiefer
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Patent number: 4725432Abstract: Solid stick compositions comprising a long-chain fatty alcohol having from about 8 to about 18 carbon atoms in the chain, volatile silicone and C.sub.20 or longer chain alcohols at levels of from about 1% to about 3% of the total long-chain fatty alcohol present in the compositions. These solid sticks have improved strength and hardness without undue brittleness.Type: GrantFiled: April 23, 1984Date of Patent: February 16, 1988Assignee: The Procter & Gamble CompanyInventor: William G. May
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Patent number: 4725613Abstract: A synergistic microbiocide comprising a member selected from the group consisting of (1) an N-alkyl (C.sub.8 -C.sub.30) dimethylbenzylammonium halide and (2) a polycondensation product of acrolein/formaldehyde in a molar ratio of 1:10-10:1 in combination with (3) a bicyclic polyoxymethylene-oxaazolidine having the formula: ##STR1## in which each R represents hydrogen, an alkyl of 1-6 carbons, phenyl, halophenyl or --(CH.sub.2 O).sub.m CH.sub.2 OH in which m is 0-2 and n is 0-4, the ratio of (1) or (2) to (3) being 1:10-10:1 by weight.Type: GrantFiled: June 17, 1987Date of Patent: February 16, 1988Assignee: Drew Chemical CorporationInventors: Frederick R. Mahn, Lora J. Bogdany, Joseph J. Baron, Edward G. Knapick, Edward M. Antonucci
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Patent number: 4725624Abstract: Bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose, of n-alkyl dimethyl benzyl ammonium chloride and 2-bromo-2-nitropropane-1,3-diol. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.Type: GrantFiled: March 13, 1987Date of Patent: February 16, 1988Assignee: Betz Laboratories, Inc.Inventors: Wilson K. Whitekettle, Deborah K. Donofrio
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Patent number: 4724142Abstract: A synergistic microbiocidal composition for inhibiting bacterial growth comprising as Component (1) a polycondensation product of acrolein/formaldehyde in a molar ratio of 1:1-10:1 and as Component (2) an N-alkyl(C.sub.8 -C.sub.30) dimethylbenzyl ammonium halide, Component (1) and Component (2) being in a weight ratio of about 1:10-10:1.Type: GrantFiled: July 20, 1987Date of Patent: February 9, 1988Assignee: Drew Chemical CorporationInventors: Frederick R. Mahn, Lora J. Bogdany, Joseph J. Baron, Edward G. Knapick, Edward M. Antonucci
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Patent number: 4708966Abstract: The present invention relates to novel specifically-substituted phenyl compounds, especially substituted di-tert-butyl phenol derivatives, which are effective as anti-inflammatory, analgesic and/or antipyretic agents. These phenyl compounds are substituted with a low molecular weight alkyl chain which terminates in a specific unsaturated functional group. These unsaturated functionalities are --C.tbd.CH, C.dbd.CH.sub.2, C.dbd.C.dbd.CH.sub.2, and aldehydes in the form of their acetals.The present invention further relates to pharmaceutical compositions which contain an anti-inflammatory agent of the present invention and a pharmaceutically-acceptable carrier.Finally, the present invention relates to methods for treating diseases characterized by inflammation, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals.Type: GrantFiled: June 27, 1986Date of Patent: November 24, 1987Assignee: The Procter & Gamble CompanyInventors: Maurice E. Loomans, Randall S. Matthews, Joseph A. Miller