Ether Doai Patents (Class 514/715)
  • Publication number: 20110105507
    Abstract: Provided are new functionalized surfactants and methods of their preparation and use. The surfactants are compounds of formula I: wherein R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 5, 2011
    Inventors: Matthias S. Ober, Edward D. Daugs, Wanglin Yu, Cynthia L. Rand
  • Patent number: 7923473
    Abstract: Pharmaceutical compositions comprising at least one compound of the formulas (Ia) or (Ib) and a pharmaceutically acceptable carrier wherein the symbols have the following meaning —X— is e.g. and Y being e.g. or the pharmaceutically acceptable salts can be applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: April 12, 2011
    Assignee: Revotar Biopharmaceuticals AG
    Inventors: Ewald M. Aydt, Remo Kranich, Anke S. Busemann
  • Patent number: 7919532
    Abstract: Pharmaceutical compositions comprising at least one compound of the formula (I) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents have the following meaning —X— is e.g. and Y being e.g. or the pharmaceutically acceptable salts, esters or amides and prodrugs can be applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: April 5, 2011
    Assignee: Revotar Biopharmaceuticals AG
    Inventors: Ewald M. Aydt, Remo Kranich
  • Publication number: 20110071225
    Abstract: A method for obtaining a sequoyitol-containing extract from a plant of genus Nephrolepis, comprising extracting with a solvent, recovering the solvent to give an extractum, subjecting the extractum to two-phase extraction and column chromatography, collecting the fractions containing sequoyitol, concentrating, filtration and drying. The main active ingredient of the extract obtained is sequoyitol, which can be used for treating diabetes and its complications.
    Type: Application
    Filed: May 19, 2008
    Publication date: March 24, 2011
    Applicant: GUANGZHOU WELMAN NEW DRUG R&D CO., LTD.
    Inventors: Tianyu Sun, Yanli Wang, Yinyin Wang, You Lu, Ting Wang
  • Patent number: 7906128
    Abstract: The present invention provides an effective method and composition for the prevention, amelioration or control of external parasites on a human or animal via the administration of a prophylactically, therapeutically or pharmaceutically effective amount of a neuronal sodium channel antagonist to a human or animal in need thereof.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: March 15, 2011
    Assignee: Wyeth LLC
    Inventors: Kathleen Heaney, Susan J. Dunney, Douglas Rugg
  • Patent number: 7906557
    Abstract: The present invention provides an oral preventive or therapeutic agent for skin damage, containing diacylglyceryl ether as an active ingredient represented by the formula (I): wherein R1 denotes C12-24 aliphatic hydrocarbon group having a degree of unsaturation of between 0 and 2; R2 denotes C12-24 acyl group having a degree of unsaturation of between 0 and 6; and R3 denotes C12-24 acyl group having a degree of unsaturation of between 0 and 6.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: March 15, 2011
    Assignee: Maruha Nichiro Seafoods, Inc.
    Inventors: Masazumi Nishikawa, Itsuki Murota, Tadakazu Tamai, Kazuyoshi Yoshikai
  • Patent number: 7897647
    Abstract: Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: March 1, 2011
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Richard B. Greenwald, Annapurna Pendri
  • Patent number: 7858611
    Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes compositions and methods based on modulation angiotensin activity to stimulate or activate the formation of new nerve cells.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: December 28, 2010
    Assignee: BrainCells Inc.
    Inventors: Carrolee Barlow, Todd A. Carter, Kai Treuner, Kym I. Lorrain
  • Patent number: 7816409
    Abstract: The present invention has as objective the stabilization of a fluoroether compound against degradation by acid substances. The stabilizers proposed are selected among propylene glycol, polyethylene glycol, hexylene glycol, 1,3-butylene glycol and a saturated cyclic alcohol preferably menthol and are used for preparing stable pharmaceutical compositions of a fluoroether compound. Method for stabilizing a fluoroether compound and use of stabilizers agents for precluding the degradation of a fluoroether are also described.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: October 19, 2010
    Assignee: Cristalia Productos Quimicos Farmaceuticos LTDA
    Inventors: Ogari Pacheco, Elisa Russo, Valter Russo, José Antônio Martins, Maria Alice Bockelmann, Simone Rosatto
  • Publication number: 20100216876
    Abstract: An antidiarrhetic composition is provided which is efficacious against diarrhea, in particular, the predominant secretory diarrhea; an antidiarrhetic medicinal composition containing the same is also provided; a food containing the antidiarrhetic composition is also provided; and a method of preventing diarrhea using the same is also disclosed. The composition for relieving diarrhea is a cool composition capable of acting on the digestive tract in the recipient's body and inhibiting the secretion of the intestinal Cl?. In other words, a composition containing one or more kinds of cool act compounds. It may be provided by adding to medicines, foods or drinks.
    Type: Application
    Filed: October 2, 2008
    Publication date: August 26, 2010
    Inventors: Yuichi Suzuki, Kenya Ishida
  • Publication number: 20100210733
    Abstract: The present invention provides a composition for inhibiting osteoclastogenesis and a pharmaceutical composition for preventing or treating a bone metabolism disorder, which comprise D-pinitol as an active ingredient. The present compositions have an inhibitory activity on the differentiation of osteoclast and are useful in the prevention or treatment of a bone metabolism disorder resulting from overactivity or hyper-proliferation of osteoclasts.
    Type: Application
    Filed: September 3, 2008
    Publication date: August 19, 2010
    Applicant: Solgent Co.
    Inventors: Jaerang Rho, Hyeon-Koon Myeong
  • Publication number: 20100184866
    Abstract: Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.
    Type: Application
    Filed: January 4, 2010
    Publication date: July 22, 2010
    Applicant: Mission Pharmacal Company
    Inventors: Mary Ann Walter, Jian Gao, Neill Bailey Walsdorf
  • Publication number: 20100160243
    Abstract: Compounds and methods for enhancing erythropoiesis. The compound contains a chemical structure of the formula (I) indicated below, in which R is a glucosyl group. In addition to having an erythropoiesis effect, the compound of the formula (1) is effective in enhancing erythropoietin formation, and increasing kidney function and expression of hepatocyte growth factor. The method includes the step of administering an effective amount of the compound of the formula (I) to a subject in need thereof and thereby results in an enhancement of erythropoiesis.
    Type: Application
    Filed: December 24, 2008
    Publication date: June 24, 2010
    Applicant: National Yang-Ming University
    Inventor: Rong-Tsun WU
  • Publication number: 20100144890
    Abstract: Use of a mixture comprising at least one non-aromatic surfactant having a plurality of ether and/or ester groups and at least one carrier agent for the preparation of a formulation for the treatment of adipose tissue disease and/or condition with improved bioavailability and lipolysis behaviour.
    Type: Application
    Filed: January 14, 2008
    Publication date: June 10, 2010
    Inventors: Peter Boderke, Bernhard Hauptmeier, Edgar Mentrup, Holger Kohler, Rainer Pooth
  • Publication number: 20100105631
    Abstract: Inositol derivatives are described that are represented by the structural formula I wherein X is a radical of scyllo-inositol wherein one or more of R1, R2, R3, R4, R5, and R6 are independently alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, sulfoxide, sulfate, sulfonyl, sulfenyl, sulfonate, sulfinyl, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, seleno, silyl, silyloxy, silylthio, carboxyl, carbonyl, carbamoyl, or carboxamide and the other of R1, R2, R3, R4, R5, or R6 are hydroxyl, or pharmaceutically acceptable salts thereof. The compounds, compositions comprising same and methods using same are described for use in the prevention and/or treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, desposition, accumulation or persistence.
    Type: Application
    Filed: November 11, 2009
    Publication date: April 29, 2010
    Inventors: Antonio Curz, Linda Kurdydyk
  • Patent number: 7704519
    Abstract: A composition for application to exterior surfaces, such as trees, so as to prevent animal damage to the exterior surface, has asphalt and denatonium benzoate mixed together. The denatonium benzoate is 1% to 50% by weight of the total composition. The asphalt is between 50% and 60% of the total composition. Naphtha and dimethyl ether are further components of the total composition. The composition is sprayable onto the exterior surface.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: April 27, 2010
    Inventor: John Baldwin
  • Publication number: 20100093871
    Abstract: Disclosed is an agent for prevention or treatment of iron overload disorders, comprising 22?-methoxyolean-12-ene-3?,24(4?)-diol or a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: March 19, 2008
    Publication date: April 15, 2010
    Applicant: MEIJI SEIKA KAISHA, LTD.
    Inventors: Hideaki Kagehara, Shoji Nishiyama
  • Patent number: 7695730
    Abstract: This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyols and preferably an insulating agent. The invention also relates to methods of using such compositions for lubrication, administration of active ingredients and for preventing or treating dysmenorrhea.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: April 13, 2010
    Assignee: McNeil-PPC, Inc.
    Inventors: Nawaz Ahmad, Christopher Scott Lamb, Emilia Casilio Lonardo, Michael E. Joyce, Kalpana J. Patel, Pavan Kumar Heda
  • Publication number: 20100076080
    Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.
    Type: Application
    Filed: August 14, 2009
    Publication date: March 25, 2010
    Inventors: Kenneth Edward Yelm, Gregory Mark Bunke, John Christian Haught
  • Patent number: 7670615
    Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: March 2, 2010
    Assignee: Stockhausen GmbH
    Inventors: Marcel Veeger, Markus Himming
  • Patent number: 7658941
    Abstract: This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent as well as gel and jelly compositions related thereto. The invention also relates to methods of using such compositions for lubrication, administration of active ingredients and for preventing or treating dysmenorrhea.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: February 9, 2010
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Nawaz Ahmad, Christopher Scott Lamb, Emilia Casilio Lonardo, Michael E. Joyce, Kalpana J. Patel, Pavan Kumar Heda
  • Publication number: 20090306196
    Abstract: The present invention relates to a delivery system based on a film of an imine forming liquid crystalline phase, mixed with at least with one biologically active substance, to which a constant or variable electric field can be applied. The delivery system can be used as a delivery system for biologically active substances such as flavors, fragrances, bactericides, fungicides, insecticides, insect attractants or repellents, agrochemicals or pharmaceuticals.
    Type: Application
    Filed: March 19, 2007
    Publication date: December 10, 2009
    Applicants: FIRMENICH SA, UNIVERSITE LOUIS PASTEUR, Centre National De La Recherche Scientifique
    Inventors: Jean-Marie Lehn, Nicolas Giuseppone, Andreas Herrmann
  • Publication number: 20090298936
    Abstract: The present invention relates to a method for energizing a human being and to administering an energizing (personal care) composition to human beings wherein said composition contains one or more fragrance materials of group (a) of the present invention.
    Type: Application
    Filed: May 29, 2008
    Publication date: December 3, 2009
    Applicant: SYMRISE GmbH & Co. KG
    Inventors: James G. Clothier, JR., Keith McDermott, Patrice Bellon
  • Publication number: 20090227685
    Abstract: The present invention is directed to novel compounds of the general formula wherein R is hydrogen, a straight, branched or cyclic hydrocarbon moiety consisting of less than 10, most preferably less than 4 carbon atoms and containing single and/or double bonds, an acetyl group and substituted acetyl groups including cyclic groups, such as cyclopropyl acyl group, alkoxy ether groups and alkyl substituted alkoxy ether moieties such as, but not limited to, CH2—O—CH2—R5 wherein R5 is a C1-C4 alkyl group as well as double bond containing alkyl groups; R1 is selected from the group consisting of hydrogen or a C1-C4 alkyl group and R2 and R3 is independently equal to methyl; and wherein one of the dashed lines between the 5 and 10 position, the 4 and 5 position and the 5 and 6 position represents a second C—C bond in a C?C double bond.
    Type: Application
    Filed: April 11, 2008
    Publication date: September 10, 2009
    Inventors: Anubhav P.S. Narula, Edward Mark Arruda, Paul J. Pieschl
  • Publication number: 20090196939
    Abstract: A method for antimicrobial treatment (e.g. antimicrobial treatment of food packaging and equipment) comprising applying to microbes a composition containing a diluting solvent (e.g., water), an antimicrobially-active solvent having a density different from the density of the diluting solvent, and an optional cosolvent, surfactant, or additional antimicrobial agent, wherein the amount of antimicrobially-active solvent or additional antimicrobial agent is sufficiently high and the amount of cosolvent or surfactant is sufficiently low so that the composition will provide greater than a 1-log order reduction in the population of bacteria or spores of Bacillus cereus within 10 seconds at 60° C. Preferred methods of the invention employ compositions containing an additional antimicrobial agent such as peroxyacetic acid. Compositions for use in the method can be prepared as concentrates, and used full strength or in diluted form.
    Type: Application
    Filed: February 9, 2009
    Publication date: August 6, 2009
    Applicant: ECOLAB INC.
    Inventors: Robert D.P. Hei, Guang-jong J. Wei, David A. Halsrud, Kim R. Smith, Teresa C. Podtburg
  • Publication number: 20090105260
    Abstract: An IR spectroscopic technique provides methods for measuring the irritation potential of a formulation and to assess the ability of molecules to enhance the permeability of substances into and through skin using samples comprising stratum corneum. Molecules are screened for their performance as chemical penetration enhancers using a unique in silico procedure that may be applied iteratively in an attempt to generate molecules showing successively higher performance. Both the irritation potential and the ability of the molecule to enhance penetration are considered in the in silico approach. The invention provides specific molecules that may be used in topical or transdermal formulations to improve the delivery of actives. The structures of compounds of the invention include: Formulas (I), (II), (III), (IV), (V), (IV) and analogs thereof.
    Type: Application
    Filed: January 17, 2006
    Publication date: April 23, 2009
    Inventors: Samir Mitragotri, Pankaj Karande, Amit K. Jain
  • Patent number: 7504091
    Abstract: antiperspirant compositions comprise an antiperspirant active and a carrier oil in which the carrier oil comprises an aromatic ester oil obeying the general formula: R1—CO2—X—Y—R2 in which R1 and R2 each represent a phenyl group, X represents an alkylene group containing from 2 to 4 carbons including at least one pendant alkyl group and Y represents a bond, or an ether or ester linkage.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: March 17, 2009
    Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.
    Inventor: Kevin Ronald Franklin
  • Patent number: 7485666
    Abstract: The invention provides compositions and methods for increasing cell growth, stimulating cell turnover and promoting the secretion of mucus within the reproductive tract of a female mammal.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: February 3, 2009
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Julie M. Villanueva, Sohail Malik
  • Patent number: 7473711
    Abstract: The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
  • Publication number: 20080280972
    Abstract: A proliferation of cells can be reduced by contacting the cells with a compound having formula (I) where R and R? are each alkyl groups, R? is hydrogen or an alkyl group and X3, X4 and X5 are each independently selected from the group consisting of hydrogen, benzyl, t-butyldimethylsiloxy radical and triphenylmethyl. Accordingly, compounds of formula (I) can be used for treatment of tumors including melanoma. Also a secretion of a matrix metalloproteinase (MMP) enzyme by cells can be reduced by contacting the cells with the compound having formula (I). Accordingly, compounds of formula (I) can be used for treatment physiological conditions associated with an elevated MMP level, such as tumors.
    Type: Application
    Filed: April 18, 2008
    Publication date: November 13, 2008
    Inventors: Raymond Dwek, Wanda Buzgariu, Anca Hirtopeanu, Robert Moriarty, Gabriela Negroiu, Norica Nichita, Livia Zdrentu, Nicole Zitzmann
  • Publication number: 20080206365
    Abstract: Provided are a certain compounds and compositions useful for inhibiting or activating the production of various types of cytokines. Also provided are certain compounds and compositions for preventing or treating various diseases attributable to abnormal cytokine production or compromised immunity.
    Type: Application
    Filed: February 28, 2007
    Publication date: August 28, 2008
    Inventors: Yoshihisa Tachibana, Shoichiro Kurata, Yoshiteru Oshima, Kazunori Ueda, Haruhisa Kikuchil
  • Patent number: 7413738
    Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: August 19, 2008
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Susan Adler, legal representative, Richard B. Greenwald
  • Patent number: 7414079
    Abstract: Acyclic compounds containing an ether functionality external to the ring can be used as rhinologically active substances. In the regions of the mouth, the throat and the airways they produce a refreshing and clearing feeling.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: August 19, 2008
    Assignee: Symrise GmbH & Co. KG
    Inventors: Horst Surburg, Arnold Machinek, Hubert Loges
  • Publication number: 20080171794
    Abstract: The present invention relates to a humectant composition containing, as component (A), at least one member selected from a menthol derivative represented by the following formula (1) and p-menthane-3,8-diol: in which R is an alkylene group having 2 to 5 carbon atoms which may be substituted with at least one member selected from the group consisting of a methyl group and a hydroxyl group, and n is an integer of 1 to 3. The humectant composition of the present invention provides an excellent moisture-retention effect.
    Type: Application
    Filed: January 16, 2008
    Publication date: July 17, 2008
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Tetsuya Yamamoto, Kenya Ishida
  • Patent number: 7365097
    Abstract: Disclosed herein is the cosmetic use, as a desquamating agent, of at least one (dihydro)jasmonic acid derivative of a given formula. Further disclosed herein is a cosmetic method for smoothing the visible and/or tactile irregularities of the skin surface, for example, for smoothing wrinkles and fine lines and/or skin spots and/or smoothing the skin, comprising topically applying, to the skin, a composition comprising, in a physiologically acceptable medium, at least one (dihydro)jasmonic acid derivative and glycerine. Other embodiments disclosed herein are novel (dihydro)jasmonic acid derivatives.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: April 29, 2008
    Assignee: L'Oreal, S.A.
    Inventors: Michel Neuwels, Maria Dalko
  • Publication number: 20080031961
    Abstract: The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example, personal care, cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.
    Type: Application
    Filed: August 1, 2007
    Publication date: February 7, 2008
    Inventors: Philip Andrew Cunningham, Jiten Odhavji Dihora, Ziayou Liu, Peggy Dorothy Sands, Sandra Jacqueline Guinebretiere
  • Patent number: 7282523
    Abstract: The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: October 16, 2007
    Inventor: Darrick S. H. L. Kim
  • Patent number: 7135600
    Abstract: The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: November 14, 2006
    Assignee: Glaxo Group Limited
    Inventors: Keith Biggadike, Diane Mary Coe, Stephen Barry Guntrip, Brian Edgar Looker, Panayiotis Alexandrou Procopiou
  • Patent number: 7122189
    Abstract: Activated polymeric bicine derivatives such as as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: October 17, 2006
    Assignee: Enzon, Inc.
    Inventors: Hong Zhao, Richard B. Greenwald, Annapurna Pendri
  • Patent number: 7109245
    Abstract: Methods and compounds for reversing pathological vasodilation of blood vessels, for example vasodilation caused by activation of CB1-like receptors, by administering to a subject a therapeutically effective amount of a compound sufficient to induce vasoconstriction, the compound comprising: wherein dashed lines independently represent either a single or a double bond, R1 is a lower alkyl, R2 is a lower alkyl, R3 is a lower alkyl or halogen, R4 is a lower alkyl or hydrogen, R5 is a lower alkyl or hydrogen, R6 is a hydrogen, lower alkyl or halogen, and R7 is a hydrogen, lower alkyl or halogen. The vasoconstrictor can be used for a variety of purposes, including hemostasis or the treatment of shock, for example vasodilatory shock syndromes such as septic shock.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: September 19, 2006
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Organix Inc.
    Inventors: George Kunos, Raj K. Razdan
  • Patent number: 7109246
    Abstract: A formulation, for example an oil-in-water emulsion, comprising an amphoteric surfactant, alkoxylated cetyl alcohol and a polar drug. The drug may be sodium cromoglycate or nedocromil sodium. The formulation may be useful in the treatment of skin disease such as atopic dermatitis.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: September 19, 2006
    Assignee: Hewlett Healthcare Ltd
    Inventor: Brian Hawtin
  • Patent number: 7087229
    Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: August 8, 2006
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Richard B. Greenwald
  • Patent number: 7056862
    Abstract: The invention provides an agricultural chemical enhancer and an agricultural chemical composition which are safely used for crops without any phytotoxicity, have a potency enhancing action on various agricultural chemicals and promote the growth of a plant body to be intended to be grown. The invention relates to an agricultural chemical enhancer comprising at least one type selected from a specific alcohol compound, an ether compound and an ester compound.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: June 6, 2006
    Assignee: Kao Corporation
    Inventors: Toshio Hayashi, Tadayuki Suzuki, Kazuhiko Kurita
  • Patent number: 6903114
    Abstract: Compounds of formula (I?), wherein A, R1 to R3 and t are as defined in the disclosure, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: June 7, 2005
    Assignee: Orion Corporation
    Inventors: Reijo Bäckström, Jarmo Pystynen, Timo Lotta, Martti Ovaska, Jyrki Taskinen
  • Patent number: 6849276
    Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.
    Type: Grant
    Filed: August 24, 1999
    Date of Patent: February 1, 2005
    Assignee: Action Pin
    Inventors: Ghislain Dufau, Michel Barsacq, Gérard Molla
  • Patent number: 6831105
    Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: December 14, 2004
    Assignee: Esperion Therapeutics, Inc.
    Inventor: Jean-Louis Henri Dasseux
  • Patent number: 6773727
    Abstract: Low concentrations of gossypol and related phyllophage toxins from cotton improve the effectiveness of insecticidal agents against social insects, including cockroaches, and particularly termites and ants. Levels of gossypol and other cotton phyllophage toxins which are sufficiently low as to be non-biocidal to social insects alone, will significantly increase the control efficacy of other insecticidal agents. Consequently, use of these low levels of these cotton phyllophage toxins allows the levels of insecticidal agents necessary for effectively controlling the insects to be significantly reduced relative to applications without cotton phyllophage toxins. Furthermore, insecticidal agents which are normally ineffective for control of social insects when used alone, may be effective when used in conjunction with the cotton phyllophage toxins.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: August 10, 2004
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Maria G. Rojas, Juan A. Morales-Ramos, Peter J. Wan
  • Patent number: 6770636
    Abstract: Compounds of formula 1, wherein: R1 is hydrogen, hydroxy, CF3, NO2, CN, halogen, C1-C8-alkyl, or C1-C8-alkoxy; R2, R3, and R4 independently of one another are hydrogen, C1-C8-alkyl, hydroxy, NO2, CN, C1-C8-alkoxyl, CF3, or halogen; R5 and R6 independently of one another are hydrogen or a group consisting of C1-C8-alkyl, C2-C8-alkenyl, C3-C8-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C6-alkylene, C5-C8-cycloalkenyl, C5-C8-cycloalkenyl-C1-C6-alkylene, C6-C10-aryl, and C6-C10-aryl-C1-C6-alkylene, each optionally substituted by a group consisting of C1-C6-alkyl, C2-C6-alkenyl, halogen, C1-C6-alkyloxy, —NH2, —NH(C1-C4-alkyl), —N(C1-C4-alkyl)2, hydroxy, ═O, —COOH, —CO—OC1-C4-alkyl, —CONH2, —CONH(C1-C4-alkyl), —CON(C1-C4-alkyl)2, and CF3, or R5 and R6 together with the nitrogen atom are a saturated or unsaturated 5-, 6-, 7-, or 8-membered heterocyclic group optionally containing one or two further heteroatoms consisting of sulfur, o
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: August 3, 2004
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Klaus Fuchs, Werner Stransky, Matthias Grauert, Adrian Carter, Wolfram Gaida, Thomas Weiser, Helmut Ensinger
  • Publication number: 20040077728
    Abstract: Disclosed are retiferol derivatives of formula (I): wherein X is >C═CH2 or —CH2—; Y and Z are independently of each other hydrogen, fluorine or hydroxy; A is —O(CH2)3—, —(CH2)2-(1,2-C6H4)—, —CH═CH—(1,2-C6H4)—, —C═C—(1,2C6H4)—, —(CH2)2—CO—, —CH2—O—CO—, —CH2NHCO—, or —CH2NHCOCH2—; R1 is C1-C5-alkyl; R2 and R3 are independently of each other alkyl or perfluoroalkyl; and R4 is hydrogen, hydroxy, C1-C5-alkyl or C1-C5-alkyl or C1-C5-alkoxy; the use of such compounds to treat or present hyperproliferative skin diseases such as psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; neoplastic diseases; disorders of the sebaceous glands such as acne and seborrhoic dermatitis; the use of these compounds in reversing the conditions associated with photodamage, particularly for the oral or topical treatment of the skin damaged through sun exposur
    Type: Application
    Filed: December 4, 2003
    Publication date: April 22, 2004
    Inventors: Pierre Barbier, Franz W Bauer, Peter Mohr, Marc Muller, Wolfgang Pirson
  • Patent number: 6716876
    Abstract: The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: April 6, 2004
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk