Abstract: The present invention provides for an oral drug delivery system based on a two phase liquid coacervate system prepared from water and one or more surfactants selected from anionic, cationic, amphoteric, and non-toxic surfactants, polysaccharides, synthetic polymers and polysorbates and their derivatives, and in which a pharmaceutical component is incorporated. The delivery system may be prepared in the form of a microemulsion as well as other forms including encapuslated microparticles. The claimed oral composition is useful to delivery oral dosage forms of drugs, their salts and derivatives thereof; biologicals, enzymes, and other pharmocologically active compositions. A method to prepare the oral drug delivery system is also disclosed.
Abstract: Described are animal control compositions and methods; which compositions comprise lemon oil and .alpha.-terpinyl methyl ether taken alone or taken further together with quinine or salts thereof. The compositions can be used "as is" or in the form of a "controlled release" composition whereby the lemon oil and .alpha.-terpinyl methyl ether taken alone or further together with quinine or a salt thereof are intimately admixed (alone or with adjuvants including but not limited to other volatile, odorous ingredients) with a polymeric substance such as polyethylene in the form of pellets or functional articles, e.g., garbage bags.
Abstract: This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R.sub.1, R.sub.2, R.sub.3, R.sub.4, n and m are defined within.
Type:
Grant
Filed:
November 29, 1984
Date of Patent:
September 30, 1986
Assignee:
USV Pharmaceutical Corp.
Inventors:
Bernard Loev, Howard Jones, Wan-kit Chan
Abstract: A method of safely forcing the egress of human beings from a zone by supplying the zone with an irritating amount of 1-methoxy-1,3,5-cycloheptatriene.
Abstract: A composition capable of promoting the skin permation or percutaneous absorption of a medicament, which comprises at least one adjuvant selected from the group consisting of a saturated hydrocarbon containing 5 to 20 carbon atoms which may be substituted by halogen, an alcohol ester of aliphatic carboxylic acid containing 12 to 18 carbon atoms, an ether, a dimethylpolysiloxane having a viscosity at 25.degree. C. of not more than 6 centistokes and a cyclic polydimethylsiloxane having a viscosity at 25.degree. C. of not more than 6 centistokes, and an imidazolidinone derivative represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each are a lower alkyl group; and pharmaceutical composition for external medication.
Abstract: Cyclopropylmethyl(ene) ethers have an outstanding action in microbicidal agents for preserving industrial materials from damage or destruction by microorganisms.
Type:
Grant
Filed:
February 16, 1984
Date of Patent:
March 11, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Bernd-Wieland Kruger, Uwe Priesnitz, Gerhard Jager, Wilfried Paulus, Hermann Genth
Abstract: Substituted cyclopropylmethyl(ene) ethers of the formula ##STR1## in which X.sup.1 and X.sup.2 are identical or different and represent halogen,R.sup.1 represents hydrogen or alkyl,R.sup.2 and R.sup.3 are identical or different and represent hydrogen, alkyl, optionally substituted aryl, halogenoalkyl, hetero-alkyl, alkoxyalkyl, alkylthioalkyl, optionally substituted alkenoxyalkyl, optionally substituted alkinoxyalkyl or (di)alkylaminoalkyl,R.sup.4 represents hydrogen or alkyl,R.sup.5 and R.sup.6 are identical or different and represent hydrogen or optionally substituted radicals from the series comprising alkyl, aryl and aralkyl andR represents a trihalogenoalkenyl, alkinyl or iodoalkinyl radical,exhibit some arthropodicidal activity and synergize other known arthropodicides.
Type:
Grant
Filed:
February 1, 1984
Date of Patent:
March 11, 1986
Assignee:
Bayer Aktiengesellschaft
Inventors:
Bernd-Wieland Kruger, Uwe Priesnitz, Gerhard Jager, Wolfgang Behrenz
Abstract: Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit lipoxygenase, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
Type:
Grant
Filed:
April 25, 1983
Date of Patent:
July 2, 1985
Assignee:
Merck & Co., Inc.
Inventors:
Philippe L. Durette, Timothy F. Gallagher
Abstract: Compounds of Formula I ##STR1## wherein X is oxygen or CH.sub.2 ;A is CH.sub.2 --CH.sub.2, trans-CH.dbd.CH or C.tbd.C;W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## and the OH groups may be in the .alpha.- or the .beta.-position; D is straight chain or branched, saturated or unsaturated hydrocarbon aliphatic of from 1 to 10 carbon atoms, which may be substituted by fluorine;E is C.tbd.C or CR.sub.3 .dbd.CR.sub.4, R.sub.3 and R.sub.4 being different and being hydrogen or alkyl of 1 to 5 carbon atoms;R.sub.1 is free or functionally modified hydroxy; andR.sub.2 is alkyl, cycloalkyl, optionally substituted aryl or heterocyclic,have valuable pharmacological properties, e.g., hypotensive and bronchodilatory characteristics. They can furthermore be used for prophylaxis and therapy of coronary infarct and as a treatment for stroke. They are produced by means of reduction of the corresponding 1-carbonic acid derivatives.
Type:
Grant
Filed:
May 24, 1982
Date of Patent:
February 5, 1985
Assignee:
Schering Aktiengesellschaft
Inventors:
Werner Skuballa, Bernd Raduechel, Helmut Vorbrueggen, Jorge Casals-Stenzel, Ekkehard Schillinger, Gerda Mannesmann, Bob Nieuweboer