Benzene Ring Containing Patents (Class 514/717)
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Publication number: 20110159304Abstract: Disclosed are a composition for inhibiting a proliferation of sulphate reducing bacteria comprising at least one of 1,2-benzisothiazol-3(2H)-one, irgasan, benzyl-2-bromoacetate, 2,2-dibromo-2-cyanoacetamide, and 2-bromo-2-nitropropan-1,3-diol as effective ingredients; a method for inhibiting the proliferation of sulphate reducing bacteria comprising the step of including a sufficient amount for inhibiting the proliferation of sulphate reducing bacteria of at least one of 1,2-benzisothiazol-3(2H)-one, irgasan, benzyl-2-bromoacetate, 2,2-dibromo-2-cyanoacetamide, and 2-bromo-2-nitropropan-1,3-diol in a corrosion sensitive material or degradation sensitive material; a sheet comprising the composition; and a steel plate to which the composition is applied.Type: ApplicationFiled: June 2, 2010Publication date: June 30, 2011Applicant: KOREA GAS CORPORATIONInventors: Hong Seok Song, Young Geun Kim, Keun Chang Ryu, Young Min Baek, Young Hyo Chang
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Patent number: 7964202Abstract: Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, said dermatological/cosmetic composition having physical stability without loss of viscosity over time at a temperature ranging from 4° C. to 40° C., said dermatological/cosmetic composition having a stable flow threshold over time as measured by viscosity measurements for rheograms which measure a shear stress ? for a given rate gradient ? and which measure a rate gradient ? for a given shear stress ?, the yield value (?0) being extrapolated visually or by calculation.Type: GrantFiled: March 24, 2008Date of Patent: June 21, 2011Assignee: Galderma Research & Development, S.N.C.Inventors: Sandrine Orsoni, Nathalie Willcox
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Publication number: 20110135703Abstract: A method of treating a surgical incision uses a material coated in an antimicrobial material. The material may be a synthetic mesh, an allograft, or a xenograft. The antimicrobial material is either tryclosan or lysostaphin. The coating of the material is performed either by adsorption or by covalent bonding.Type: ApplicationFiled: December 8, 2009Publication date: June 9, 2011Inventor: John I. Shipp
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Patent number: 7943669Abstract: The present invention describes phenoxy-acetic acids and pharmaceutical compositions containing the same and methods of using the same. The phenoxy-acetic acids are activators of PPAR-? and should be useful for treating conditions mediated by the same.Type: GrantFiled: June 29, 2006Date of Patent: May 17, 2011Assignee: High Point Pharmaceuticals, LLCInventor: Soren Ebdrup
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Patent number: 7923573Abstract: A superior LXR modulator is provided. A compound represented by the general formula (I): [wherein R1: —COR9 (wherein R9: alkyl, optionally substituted alkoxy or optionally substituted amino); R2: H, OH, alkoxy, optionally substituted amino, etc.; R3: H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogeno, etc.; R4 and R5: H, optionally substituted alkyl, halogeno, etc.; R6 and R7: H, alkyl; R8: —X2R10 [wherein R10: —COR11 (wherein R11: OH, optionally substituted alkoxy, optionally substituted amino, etc.), —SO2R12 (wherein R12: optionally substituted alkyl, optionally substituted amino, etc.), tetrazol-5-yl, etc.; X2: single bond, optionally substituted alkylene, etc.]; X1: —NH—, —O—, —S—, etc.; Y1: optionally substituted phenyl, optionally substituted 5- to 6-membered aromatic heterocyclyl; Y2: optionally substituted aryl, optionally substituted heterocyclyl, etc.] and the like is provided.Type: GrantFiled: October 26, 2005Date of Patent: April 12, 2011Assignee: Daiichi Sankyo Company, LimitedInventors: Kazuhiko Tamaki, Takahiro Yamaguchi, Kozo Oda, Naoki Terasaka, Daisuke Nakai, Masakazu Nakadai
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Publication number: 20110076244Abstract: The present invention relates to skin coating compositions and methods and, in particular, to coatings containing an active agent. In some embodiments, the coating may be applied to a skin surface and may be essentially colorless and transparent. In some aspects, the coating comprises a polymer and an active agent, and the polymer may be configured for sustained release of the active agent. In some aspects, the coating forms a barrier essentially impermeable to microorganisms yet permeable to water vapor. The coating may also be flexible and conformable to the surface. The coating may be applied to the skin using any suitable method. In some embodiments, the polymer and/or active agent are dissolved and/or suspended in an alcohol solvent. In some embodiments, the alcohol may function as an antiseptic on skin.Type: ApplicationFiled: September 24, 2010Publication date: March 31, 2011Applicant: Pharmasol CorporationInventor: James Donald Hammer
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Patent number: 7910090Abstract: The present invention provides a base composition that allows for the formulation of non-irritating cosmetic and/or dermatological compositions. The base composition includes one or more of electrolyte, buffer, mild preservative, lubricant, or any combinations thereof. It is preferred that one or more of the above components are eye-safe and/or eye-compatible. The present invention also provides photoprotective cosmetic and/or dermatological compositions that include the base composition and one or more sunscreen active components and are non-irritating to mammalian eyes.Type: GrantFiled: January 18, 2006Date of Patent: March 22, 2011Assignee: Playtex Products, Inc.Inventors: Olga V. Dueva-Koganov, James P. SaNogueira
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Publication number: 20110054037Abstract: Treatment of cancer includes administering a compound of formula (I) to a subject. In particular, treatment of colorectal cancer is described.Type: ApplicationFiled: April 6, 2009Publication date: March 3, 2011Applicant: THE UAB RESEARCH FOUNDATIONInventor: Ahmad Safavy
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Publication number: 20110033402Abstract: The invention relates to a novel solubilized small molecule topical formulation for the transdermal delivery of small molecule agents comprising: a small molecule agent, one or more micelle forming compounds, one or more skin penetration enhancers, a surfactant, and one or more solvents, wherein the small molecule agent is solubilized in the solvent. The invention further relates to the use of the topical formulation as well as the process for making the topical formulation.Type: ApplicationFiled: June 29, 2010Publication date: February 10, 2011Inventor: Pankaj Modi
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Patent number: 7884089Abstract: An antimicrobial coating composition consisting essentially of 70 to 80 wt. percent water; 5 to 10 wt. percent methyl alcohol; 3 to 8 wt. percent octadecyl dimethyl trimethoxy silylpropyl-ammonium chloride; 1 to 5 wt. percent chloropropyl trimethoxysilane; 0.5 to 1.5 wt. percent aminopropyltrialkoxysilane; 0.5 to 1.5 wt. percent of a surfactant; 1 to 1.5 wt. percent of an anti-microbial agent; and 0.5 to 2.5 wt. percent sulfuric acid.Type: GrantFiled: February 6, 2009Date of Patent: February 8, 2011Assignee: Xurex, Inc.Inventor: Bo H. Gimvang
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Publication number: 20110028545Abstract: The present invention relates to a process for producing concentrates of antimicrobial active ingredients, the concentrates themselves and their use for producing solid, liquid or pasty body cleaning compositions, such as in particular soaps.Type: ApplicationFiled: January 12, 2009Publication date: February 3, 2011Applicant: LANXESS DEUTSCHLAND GMBHInventors: Gerd-Friedrich Renner, Otto Exner, Rolf Matysiak, Josef Wellmann, Udo Hennen
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Patent number: 7820186Abstract: Dermatological/cosmetic gel compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise (i) at least one retinoid, (ii) dispersed benzoyl peroxide and (iii) at least one pH-independent gelling agent, formulated into (iv) a physiologically acceptable medium therefor.Type: GrantFiled: December 23, 2002Date of Patent: October 26, 2010Assignee: Galderma Research & DevelopmentInventors: Sandrine Orsoni, Nathalie Willcox
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Publication number: 20100249246Abstract: A (?)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic.Type: ApplicationFiled: May 8, 2008Publication date: September 30, 2010Applicant: PharmacoFore, Inc.Inventor: Thomas E. Jenkins
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Publication number: 20100222406Abstract: The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channel inhibitor, a prodrug thereof, or a pharmaceutically acceptable salt of said inhibitor or prodrug, wherein the T type calcium channel inhibitor has a structure represented by Formula (I): Formula (I), wherein R1 is selected from the group consisting of C1-C4 alkyl, hydroxy and C1-C4 alkoxy; X is selected from the group consisting of N and CH; Z is selected from the group consisting of NH, O, S and CH2; R2 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy; and R3 is selected from the group consisting of H, halo, NH2, C1-C4 alkyl, hydroxy and C1-C4 alkoxy.Type: ApplicationFiled: January 14, 2010Publication date: September 2, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Lloyd S. Gray, Doris M. Haverstick
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Publication number: 20100215775Abstract: The invention relates to the use of C10-C14-alkane-1,2-diols, in particular 1,2-decanediol, 1,2-dodecanediol and/or 1,2-tetradecanediol, in the preparation of a composition for the prophylaxis and/or treatment of Malassezia-induced dandruff formation, as well as to cosmetic and/or dermatological preparations comprising C10-C14-alkane-1,2-diols.Type: ApplicationFiled: October 12, 2007Publication date: August 26, 2010Applicant: SYMRISE GmbH & Co. KGInventors: Gerhard Schmaus, Sabine Lange
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Publication number: 20100216889Abstract: The present invention relates to cleanser compositions, and their uses, wherein the cleanser compositions comprise one or more cationic antiseptic agents, a film-forming cationic emulsifying agent, a dispersing auxiliary solvent, a solvent system, and optionally an alkanediol.Type: ApplicationFiled: June 6, 2008Publication date: August 26, 2010Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OFInventors: Shanta M. Modak, Ingrid Geraldo, Lauserpina Caraos, Nayana Baiju
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Publication number: 20100190832Abstract: Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. Derivative of biphenyl ethers (BPE), which are shown to interact with a high affinity to its T4 binding site thereby preventing its aggregation and fibrillogenesis. They prevent fibrillogenesis by stabilizing the tetrameric ground state of transthyretin. Two compounds (2-(5-mercapto-[1,3,4]oxadiazol-2-yl)-phenol and 2,3,6-trichloro-N-(4H-[1,2,4]triazol-3-yl) exhibit the ability to arrest TTR amyloidosis. The dissociation constants for the binding of BPEs and compound 11 and 12 to TTR correlate with their efficacies of inhibiting amyloidosis. They also have the ability to inhibit the elongation of intermediate fibrils as well as show nearly complete (>90%) disruption of the preformed fibrils. Biphenyl ethers and compounds 11 and 12 as very potent inhibitors of TTR fibrillization and inducible cytotoxicity.Type: ApplicationFiled: October 15, 2009Publication date: July 29, 2010Inventor: Avadhesha Surolia
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Publication number: 20100187263Abstract: This invention relates to compositions containing lower (C1-C4) alcohol and a polymeric fluorosurfactant formulated for being dispensed as a foam product. More particularly, the invention relates to improved compositions formulated with polymeric fluorosurfactants with pendant perfluoroalkyl side chains of a fully fluorinated chain length of C1-C7. The compositions also relate to use for personal care, such as skin sanitizing and cleansing.Type: ApplicationFiled: April 2, 2010Publication date: July 29, 2010Applicant: The Clorox CompanyInventors: David Lestage, David R. Scheuing, Scott L. Cumberland, Grant Templin
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Publication number: 20100172848Abstract: The present invention relates to a skin or surface disinfectant composition with broad spectrum antimicrobial activity comprising one or more essential oil (and/or one or more component thereof) and one or more fruit acid. The compositions of the invention may be used as non-toxic alternatives to conventional disinfectants or may be added to other antimicrobial agents to enhance their activity. The invention provides effective alternatives to harsher products which may be particularly useful in personal care and household products and where children and/or pet exposure may be a concern.Type: ApplicationFiled: January 26, 2010Publication date: July 8, 2010Applicant: The Trustees Of Columbia University In the City of New YorkInventors: Shanta Modak, Nayana Baiju, Lauserpina Caraos
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Publication number: 20100173904Abstract: A tropical composition is provided. The topical composition can be prepared by diluting a topical composition precursor with water and adding additional components, if desired. The topical composition precursor can be prepared by melt processing a hydrophobic polymer composition that includes repeating pyrrolidone/alkylene groups wherein the alkylene groups contain at least 10 carbon atoms, and a hydrophilic polymer composition including repeating carboxylic groups and/or repeating hydroxyl groups. A topical composition precursor and methods for manufacturing and using a topical composition are provided by the invention.Type: ApplicationFiled: March 8, 2010Publication date: July 8, 2010Applicant: Skinvisible Pharmaceuticals, Inc.Inventors: James A. Roszell, Bruce Jezior
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Patent number: 7709523Abstract: ?-Aminoamide derivatives useful as antimigraine agents, particularly for the treatment of head pain conditions such as migraine, cluster headache or other severe headache, are disclosed. The antimigraine agents of the invention are able to reduce or even stop the pain deriving from such conditions without, virtually, any side effects.Type: GrantFiled: November 18, 2003Date of Patent: May 4, 2010Assignee: Newron Pharmaceuticals SpAInventors: Patricia Salvati, Marcello Calabresi, Luciano Dho, Orietta Veneroni, Piero Melloni
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Publication number: 20100099642Abstract: The invention relates to the use of TGF-beta stimulating agents, and in particular members of the triphenylethylene class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of symptoms of cardiovascular disease, autoimmune diseases or neurodegeneration. In particular, improved compositions consisting of triphenylethylene agents combined with one or more additional active pharmaceutical agents in order to mitigate against side-effects of the triphenylethylene are described and claimed.Type: ApplicationFiled: February 7, 2008Publication date: April 22, 2010Applicant: TCP Innovations LimitedInventor: David J. Grainger
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Patent number: 7674817Abstract: The antimicrobial acid-catalyzed coating composition of the invention is an acid-catalyzed coating composition formulated with at least one antimicrobial agent to provide antimicrobial activity to the coating composition and an article coated therewith.Type: GrantFiled: May 12, 2005Date of Patent: March 9, 2010Assignee: Akzo Nobel Coatings International B.V.Inventor: James H. Bray, III
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Patent number: 7632805Abstract: Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.Type: GrantFiled: September 14, 2005Date of Patent: December 15, 2009Assignees: University of South Florida, Yale UniversityInventors: Said Sebti, Andrew D. Hamilton
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Patent number: 7629004Abstract: This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal perborate, at least one inhibiting compound selected from the group consisting of alkali metal silicates, triazoles and mixtures thereof in any ratio, at least one corrosion inhibitor, and effective amounts of surfactant.Type: GrantFiled: January 31, 2007Date of Patent: December 8, 2009Assignee: The United States of America as represented by the Secretary of the NavyInventors: El Sayed S. Arafat, Craig A. Matzdorf, Stephen J. Spadafora, David L. Gauntt, Paul R. Roser, James A. Whitfield
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Patent number: 7625950Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and n are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.Type: GrantFiled: April 29, 2004Date of Patent: December 1, 2009Assignee: Novartis AGInventors: Klaus Hinterding, Carsten Spanka, Frédéric Zecri
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Publication number: 20090258951Abstract: A use of Vanillyl alcohol for treatment of Parkinson's disease is disclosed in accordance with the present invention. The Vanillyl alcohol's formula is 4-hydroxy-3-methoxy-benzyl alcohol and similitude with the human neurotransmitter dopamine. The Vanillyl alcohol has dopamine receptor stimulant and which is applied for pharmaceutical preparation of treating Parkinson's disease.Type: ApplicationFiled: July 3, 2008Publication date: October 15, 2009Applicant: Red Pharma & Biotech Research CorporationInventors: Lun-Chung Hsu, Zhi-Hong Wen, Kuan-Yu Lee
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Patent number: 7582803Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.Type: GrantFiled: September 8, 2006Date of Patent: September 1, 2009Assignee: Amgen Inc.Inventors: Michelle Akerman, Sean Brown, Jonathan B. Houze, Jinqian Liu, Jiwen Liu, Zhihua Ma, Julio C. Medina, Wei Qiu, Michael J. Schmitt, Yingcai Wang, Liusheng Zhu, Rajiv Sharma
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Publication number: 20090170886Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: ApplicationFiled: July 7, 2006Publication date: July 2, 2009Inventors: Mark Laurence Boys, Michelle Marie Bruendl, Victoria Leigh Downs, Stephen Alan Fakhoury, William Glen Harter, Lain-Yen Hu, Sandra Marie Jennings, Bruce Allen Lefker, Lorna Helen Mitchell, Raj Kumar Raheja, Yvonne Dorothy Smith
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Publication number: 20090156687Abstract: Discovery and characterization of an apicomplexan Fab I gene and encoded enzyme and discovery of the triclosan as a lead compound, provide means to rationally design novel inhibitory compositions useful for prevention and treatment of apicomplexan related diseases.Type: ApplicationFiled: November 5, 2007Publication date: June 18, 2009Inventors: Rima McLeod, Michael Kirisits, Dennis Kyle, Douglas G. Mack, Wilbur Milhous, Stephen Muench, Ernest J. Mui, Sean Prigge, John Rafferty, David Rice, Craig W. Roberts, Benjamin Samuel
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Publication number: 20090149445Abstract: The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula I, including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula I.Type: ApplicationFiled: July 15, 2008Publication date: June 11, 2009Inventors: Michael Joseph Coghlan, Jonathan Edward Green, Timothy Alan Grese, Prabhakar Kondaji Jadhav, Donald Paul Matthews, Mitchell Irvin Steinberg, Kevin Robert Fales, Michael Gregory Bell
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Patent number: 7524516Abstract: The corrosion inhibiting mildew remover kit includes a premeasured amount of sodium perborate, a premeasured amount of a liquid inhibitor and a premeasured amount of a liquid blend. The premeasured amount of sodium perborate, the premeasured amount of liquid inhibitor, the premeasured amount of liquid blend and water combine to form an aqueous solution that can be applied to a mildew infected area. The aqueous solution removes mildew from a mildew infected area and does not cause corrosion.Type: GrantFiled: January 26, 2006Date of Patent: April 28, 2009Assignee: The United States of America as represented by the Secretary of the NavyInventors: El Sayed S. Arafat, Raymond D. Rose, Paul R. Roser
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Publication number: 20090104133Abstract: Methods of using absorption enhancer as a component of skin care compositions for moisturizing and protecting the skin. Antimicrobial skin care compositions for cleansing and moisturizing the skin, comprising an absorption enhancer, an antimicrobial function enhancer and bound lipid removals, humectants, emollients and extracts of botanical herbs. Methods for preparing skin care compositions comprising an absorption enhancer.Type: ApplicationFiled: November 21, 2008Publication date: April 23, 2009Inventor: Zahra Mansouri
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Patent number: 7494670Abstract: This invention comprises a composition and the process of using the composition for removing and preventing mold, mildew, and fungal growth. The composition comprises at least one alkali metal perborate, at least one inhibiting compound selected from the group consisting of alkali metal silicates, triazoles and mixtures thereof in any ratio, at least one corrosion inhibitor, and effective amounts of surfactant.Type: GrantFiled: June 10, 2005Date of Patent: February 24, 2009Assignee: United States of America as represented by the Secretary of the NavyInventors: El Sayed S. Arafat, Craig A. Matzdorf, Stephen J. Spadafora, David L. Gauntt, Paul R. Roser, James A. Whitfield
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Patent number: 7473711Abstract: The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: GrantFiled: April 15, 2005Date of Patent: January 6, 2009Assignee: Pfizer Inc.Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker
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Publication number: 20080312186Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.Type: ApplicationFiled: August 19, 2008Publication date: December 18, 2008Applicant: The University Court of the University of AberdeenInventors: Stuart H. RALSTON, Iain R. GREIG, Aymen I. I. MOHAMED, Robert J. VAN 'T HOF
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Publication number: 20080293806Abstract: An odor-reducing composition for counteracting malodour in which the composition includes an odor reducing material of the type phenyl ethyl methyl ether, Cyprisate, Camonal and paracresyl methyl ether and a method for counteracting malodour employing such a composition.Type: ApplicationFiled: May 11, 2005Publication date: November 27, 2008Inventors: Keith Douglas Perring, Anne Richardson, Christine Margaret Goulding, Jean Pascal Osmont
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Publication number: 20080293824Abstract: The invention relates to the use of phenylether derivatives of formula (I), to compositions thereof for the control of pests, including arthropods and helminths.Type: ApplicationFiled: April 3, 2008Publication date: November 27, 2008Inventors: Stefan Schnatterer, Michael Maier, Friederike Lochhaas, Werner Knauf, Karl Seeger
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Publication number: 20080249136Abstract: An antimicrobial composition containing a cationic polymer having limited antimicrobial activity (such as a hydrophobically-modified quaternary ammonium cellulose ether) and an antimicrobial compound (such as one or more compounds selected from the group consisting of diiodomethyl-para-tolylsulfone, ortho-phenylphenol, sodium pyrithione, zinc pyrithione, 3-iodo-2-propynylbutylcarbamate, 2-methyl-4-isothiazolin-3-one, 1,2-benzisothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one, 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride, 2-(4-thiazolyl)-benzimidazole, ?-bromo-?-nitrostyrene, 2,4,4?-trichloro-2-hydroxyphenyl ether, chloroxylenol, chlorocresol, para-tert-amylphenol, N-(4-chlorophenyl)-N?-(3,4 dichlorophenyl)-urea, and para-hydroxybenzoic acid esters). The growth of microorganisms (such as Pseudomonas aeruginosa) can be inhibited by exposing the microorganism to such a composition.Type: ApplicationFiled: October 25, 2006Publication date: October 9, 2008Inventors: Ioana Annis, Charles D. Gartner
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Patent number: 7432306Abstract: The present invention has an object to develop novel compounds which are effective for the therapy of syndrome X, cancer, myxedema, vascular chronic inflammation and the like, and furthermore prevent/treat the restenosis caused in an artery expansion by a balloon or a stent and have the activity facilitating regenerative medicine by inhibiting rejection of own cells or tissues to be transplanted and the method for preparing the same. Novel acetal derivatives obtained by acylating the hydroxyl group at the 2-position of the orcylaldehyde which ascochlorin and its analogs have and thereafter bonding an alcohol to the aldehyde group in the presence of a basic catalyst are found to achieve the object.Type: GrantFiled: September 7, 2005Date of Patent: October 7, 2008Assignee: NRL Pharma, Inc.Inventors: Takeshi Kitahara, Hidenori Watanabe, Kunio Ando
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Publication number: 20080220038Abstract: There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene component.Type: ApplicationFiled: January 24, 2005Publication date: September 11, 2008Inventors: Lanny Franklin, Elizabeth Cloud, Lanna Knapp, Gary Ostroff
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Patent number: 7420003Abstract: The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a catalyst and in the presence of a phosphine ligand. The compounds synthesized may be used in pharmaceutical preparations for the treatment of a variety of diseases and conditions.Type: GrantFiled: May 28, 2004Date of Patent: September 2, 2008Assignee: Astrazeneca ABInventors: Keith Fagnou, Mark Lautens
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Publication number: 20080206294Abstract: Several derivatives of naphthalene, including 1?-acetonaphthone, 2?-acetonaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of termites, and resulted in significant reduction in termite feeding activity. For example, 2?-acetonaphthone was found to be an effective repellent and feeding deterrent of termites. Termites exposed to concentrations as low as 8 mg/kg sand exhibited a significant reduction in tunneling and feeding activity. Moreover, some of the dead termites had symptoms indicative of a failure to molt. At concentrations ?20 ?g/cm2, 2?-acetonaphthone was a strong repellent. Interestingly, at 160-fold lower concentration (0.125 ?g/cm2), 2?-acetonaphthone stimulated termite feeding activity. As a sand barrier, 2?-acetonaphthone significantly inhibited tunneling and feeding activity in concentrations from 8.33 to 35.0 mg/kg. Molting problems were also identified in termites exposed to 2?-acetonaphthone.Type: ApplicationFiled: February 1, 2008Publication date: August 28, 2008Inventors: Gregg Henderson, Sanaa A. Ibrahim, Rosemary Patton, Roger A. Laine, Betty C.R. Zhu, Feng Chen
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Publication number: 20080175811Abstract: Composition for application to skin comprising a biocide or combination of biocides (such as chlorhexidine, halogenated phenols, quaternary ammonium compounds; povidone-iodine; zinc pyridinethione; alcohols etc) and at least one transcutaneous vehicle (for example alkyl methyl sulfoxides, alkyl pyrrolidones, glycols, glycol ethers and glycol esters) effective to convey the biocide to a sub epidermal “resident” micro-organism. Also a method for preparing a patient for surgery comprising the step of treating an area of the patient's skin at, and in the surrounding the vicinity of, the site of an intended surgical incision with a composition effective to kill more than 93% of both “transient” and “resident” micro-organisms.Type: ApplicationFiled: April 28, 2006Publication date: July 24, 2008Applicant: Novapharm Research (Australia) Pty Ltd.Inventor: Steven Kritzler
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Publication number: 20080171788Abstract: The invention relates to a medicament for IBS, which comprises a dual antagonist for 5-HT2B and 5-HT7 receptors having selective binding affinities for 5-HT2B and 5-HT7 receptors. The pharmaceutical composition of the invention is useful as a drug which is excellent in the therapeutic effect on IBS and shows lessened side effects occurring in the existing remedies for IBS, because it showed good pharmacological actions in comparison with the case of independently using a 5-HT2B receptor antagonist having selective binding affinity for 5-HT2B receptor or a 5-HT7 receptor antagonist having selective binding affinity for 5-HT7 receptor.Type: ApplicationFiled: February 7, 2006Publication date: July 17, 2008Inventors: Shinobu Akuzawa, Hiroyuki Ito, Toshihiro Watanabe, Hiroyoshi Yamada
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Publication number: 20080161247Abstract: The present disclosure provides a composition for enhancing effect of an inhibitor in inhibiting NAD+/NADP+ or NADH/NADPH dependent enzymes. The inhibition of the NAD+/NADP+ or NADH/NADPH dependent enzymes such as Enoyl-ACP reductase (ENR) by the composition of the present disclosure serves as a target for treating malaria and other infectious diseases. The present disclosure provides composition comprising inhibitor and polyphenol, wherein the polyphenol was found to enhance the inhibitory activity of the inhibitor. The present disclosure provides method for treating an infectious disease comprising administering an effective amount of the composition of the present disclosure to patients in need thereof.Type: ApplicationFiled: December 19, 2007Publication date: July 3, 2008Inventors: Avadhesha Surolia, Shailendra K. Sharma, Namita Surolia, Prasanna Parasuraman, Gyanendra Kumar
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Publication number: 20080124300Abstract: This invention relates to a stabilized honey bee pheromone and methods of stabilizing the honey bee brood pheromone, thereby enabling the production and sustained use of commercial products based on that pheromone. The stabilized pheromone can be used to manipulate the behavior and improve the performance of worker honey bees, resulting in overall increased vigor of the hive. The pheromone composition comprises two or more of ethyl linoleate, ethyl linolenate, ethyl oleate, ethyl palmitate, ethyl stearate, methyl linoleate, methyl linolenate, methyl oleate, methyl palmitate and methyl stearate and an antioxidant.Type: ApplicationFiled: September 7, 2006Publication date: May 29, 2008Applicant: PHERO TECH INC.Inventors: Tanya Pankiw, Jean Pierre Lafontaine, Norman Avelino
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Patent number: 7351744Abstract: Several derivatives of naphthalene, including 1?-acetonaphthone, 2?-acetpnaphthone, 1-methoxynaphthalene, and 2-methoxynaphthalene, were discovered to be effective toxicants and repellents of termites, and resulted in significant reduction in termite feeding activity. For example, 2?-acetonaphthone was found to be an effective repellent and feeding deterrent of termites. Termites exposed to concentrations as low as 8 mg/kg sand exhibited a significant reduction in tunneling and feeding activity. Moreover, some of the dead termites had symptoms indicative of a failure to molt. At concentrations ?20 ?g/cm2, 2?-acetonaphthone was a strong repellent. Interestingly, at 160-fold lower concentration (0.125 ?g/cm2), 2?-acetonaphthone stimulated termite feeding activity. As a sand barrier, 2?-acetonaphthone significantly inhibited tunneling and feeding activity in concentrations from 8.33 to 35.0 mg/kg. Molting problems were also identified in termites exposed to 2?-acetonaphthone.Type: GrantFiled: August 14, 2003Date of Patent: April 1, 2008Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: Gregg Henderson, Sanaa A. Ibrahim, Rosemary Patton, Roger A. Laine, Betty C. R. Zhu, Feng Chen
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Publication number: 20080014261Abstract: The present invention relates to compositions that comprise immediate release and extended release guaifenesin, extended release phenylephrine and immediate and extended release dextromethorphan. The present invention also includes methods for using these compositions for treatment of patients suffering from, for example and without limitation, coughing, sneezing, rhinorrhea, and/or nasal obstruction.Type: ApplicationFiled: July 12, 2006Publication date: January 17, 2008Inventors: John A. Giordano, Kevin M. Brown
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Publication number: 20080008772Abstract: The present invention relates to compositions that comprise immediate release and extended release guaifenesin, and extended release hydrocodone bitartrate. The present invention also includes methods for using these compositions for treatment of patients suffering from, for example and without limitation, coughing, sneezing, rhinorrhea, and/or nasal obstruction.Type: ApplicationFiled: July 5, 2006Publication date: January 10, 2008Inventors: John A. Giordano, Kevin M. Brown