Abstract: A method is provided for reducing the frequency of mis-directed output of hydroalcoholic gel from a dispenser. A method of reducing the formation of coagulated gel deposits, and dispensable hydroalcoholic gel compositions are also provided.
Type:
Application
Filed:
June 14, 2010
Publication date:
December 16, 2010
Inventors:
David R. Macinga, Sarah L. Edmonds, Kristin E. Hartzell, Kelly A. Dobos, Carol A. Quezada
Abstract: A pupicidal and larvicidal composition which comprises, predominantly and in proportions which can vary from approximately 0% to approximately 100%, cetyl alcohol, and wherein the rest of the composition, where necessary, is also constituted by at least one excipient.
Abstract: The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
Type:
Grant
Filed:
June 29, 2005
Date of Patent:
December 7, 2010
Assignees:
Postech Foundation, Postech Academy-Industry Foundation
Abstract: The progression of hepatic fibrosis and hepatic cirrhosis caused by various hepatic disorders and damages such as chronic hepatitis can be restrained by hepatic fibrosis inhibitor containing a compound represented by the following chemical formula: wherein, R1 represents an alkyl group with a carbon number of 4 to 8, and R2 represents a hydrogen atom, alkylcarbonyl group with a carbon number of 2 to 6, or alkoxycarbonyl group with a carbon number of 2 to 6.
Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.
Abstract: This invention relates to methods of inhibiting a Cav3 calcium channel in a cell using a C2-C10 alkyl alcohol, or mixtures thereof. This invention further relates to methods of treating a thalamocortical dysrhythmia disorder in a mammal and for treating a neurological disorder in a mammal associated with the thalamocortical dysrhythmia using a C2-C10 alkyl alcohol, a lipophilic molecule with a partition coefficient substantially similar to that of a C2-C10 alkyl alcohol, or mixtures thereof, or a pharmaceutical composition comprising the same.
Type:
Application
Filed:
July 26, 2010
Publication date:
November 18, 2010
Applicant:
New York University
Inventors:
Rodolfo R. Llinas, Mutsuyuki Sugimori, Francisco Urbano
Abstract: Polysaccharide nanoparticles that are particularly useful in for example drug and agent delivery, tissue-specific targeting, for medical imaging and diagnosis, as well as modifiers of physico-chemical properties. The nanoparticles can be highly-branched glucose homopolymers and can be characterized by a uniform spherical shape. They are monodisperse, hydrophilic and produce low solution viscosities. The nanoparticles are non-toxic, biocompatible and biodegradable. Also, the process of isolation of said polysaccharide nanoparticles from various organisms including, but not limited to, microorganisms such as bacteria and yeasts. Also provided are methods for chemical conjugation of the polysaccharide nanoparticles with various agents. Also provided are examples of use of the polysaccharide nanoparticles and their derivatives as drug delivery systems and fluorescent di-agnostics.
Abstract: Herbal compositions and their use in the prevention and/or treatment of hepatitis are provided The herbal compositions comprise an extract of flowers, leaves, and roots from the plant genera Cordia, Annona, and Curcuma, respectively, wherein the specific species are Cordia lutea, Annona muricata and Curcuma longa.
Abstract: Multi-dose active agent packages and methods for using the same for treating a subject for a condition are provided. Aspects of the invention include a multi-dose active agent package containing a plurality of unit dosage forms of an active agent configured to modulate at least a portion of a subject's autonomic nervous system during at least one season of the year. The active agent is present in an amount sufficient to alter the parasympathetic activity/sympathetic activity ratio of the subject in a manner effective to treat the subject for the condition. The subject active agent packages and methods find use in the treatment of a variety of different conditions, including disease conditions that increase in severity and/or occurrence during one or more seasons of the year. Also provided are kits for use in practicing the subject methods.
Type:
Application
Filed:
April 15, 2010
Publication date:
October 14, 2010
Inventors:
Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee
Abstract: A rodenticidal mixture comprising a) 0.0015 to 99.89% by weight of at least one rodenticide, b) 10?8 to 95% by weight of at least one painkiller and c) 0.01 to 99.9984% by weight of at least one biocide, where the percentages by weight are based on the total of components (a), (b) and (c), is suitable for the preparation of rodenticidal bait formulations which are employed for controlling rodent pests.
Type:
Application
Filed:
September 30, 2008
Publication date:
October 14, 2010
Applicant:
BASF SE
Inventors:
Gerhard Schnabel, Michael Ishaque, Dieter Zeller, Lars Weichel, Andrej Brejc
Abstract: The present invention aims to provide ligand agents for peroxisome proliferator-activated receptors (PPARs), etc. The ligand agents of the present invention are characterized by comprising, as an active ingredient, an extract of one or more plants selected from the following: Serenoa repens, Acanthopanax senticosus, Euterpe oleracea, Elettaria cardamomum, Angelica archangelica, Psidium guajava, Prumus spinosa, Eleagnus multiflora, Ligusticum chuaxiong, Cannabis sativa, Sambucus nigra, Adinandra nitida, Passiflora incarnata, Peucedanum japonicum, Pimpinella anisum, Vitex agnus-castus, Withania somnifera, Calluna vulgaris, Crataegus monogyna, Linum usitatissimum, Pleurotus ferulae, Robinia pseudoacacia, and Acanthopanax sessiliflorus.
Abstract: The treatment and prevention of neurodegenerative diseases by repression of the transcriptional complex that silences the promoter of the UCHL1 gene.
Type:
Application
Filed:
February 24, 2010
Publication date:
September 30, 2010
Applicant:
ORYZON GENOMICS, S.A.
Inventors:
Tamara Maes, Marta Barrachina Castillo, Isidro Ferrer Abizanda
Abstract: A liquid composition for spraying upon the bristles of a toothbrush so as to deposit the composition as a spray of droplets upon the bristles of the toothbrush includes a bactericidal component which is orally safe for a user of the toothbrush to ingest, and may advantageously include purified water, tea tree oil, and alcohol.
Abstract: Antimicrobial compositions and methods of using such antimicrobial compositions to provide a reduction in populations of viable microorganisms.
Abstract: A non-toxic environmentally friendly aqueous disinfectant is disclosed for specific use as prevention against contamination by potentially pathogenic bacteria and virus. The aqueous disinfectant is formulated by electrolytically generating silver ions in water in combination with a citric acid. The aqueous disinfectant may include a suitable alcohol and/or a detergent. The aqueous disinfectant has been shown to be very effective at eliminating standard indicator organisms such as staphylococcus aureus, salmonella cholerasuis and pseudomonas aeruginosa.
Abstract: A biodelivery system has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or disintegration of the liposome proceeds. Thereafter the biocidal core is released to react directly with the biofilm encased microorganisms.
Type:
Application
Filed:
March 20, 2009
Publication date:
September 23, 2010
Inventors:
Wilson Kurt WHITEKETTLE, Kimberly Murphy, Qing Zhao
Abstract: Aqueous hard surface treatment compositions necessarily comprise an alcohol constituent selected from the group consisting of methanol, ethanol, n-propanol, isopropanol, n-butanol, benzyl alcohol, and mixtures thereof which alcohol constituent comprises from about 40 and 70 weight percent (“% wt”) of the total weight of the composition of which it forms a part. Preferably however the alcohol constituent is present in an amount of from about 50% wt to about 70% wt, more preferably is present in amounts of from about 60% wt to about 70% wt.
Type:
Application
Filed:
May 20, 2010
Publication date:
September 16, 2010
Applicant:
Reckitt Benckiser Inc.
Inventors:
Mark Timothy BENNETT, Andrew Francis Colurciello, Caryn Oryniak, Janette Kumyoung Suh, Laura Jean Vaccaro
Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.
Abstract: A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.
Type:
Grant
Filed:
November 20, 2003
Date of Patent:
September 14, 2010
Assignee:
Cephalon, Inc.
Inventors:
Dave Dickason, Bradley T. McIntyre, Piyush R. Patel
Abstract: The present invention relates to methods for treating and preventing acne or P. acnes infection in a subject comprising topically administering to the subject in need thereof an anti-acne nanoemulsion composition.
Type:
Application
Filed:
January 28, 2010
Publication date:
September 9, 2010
Inventors:
Joyce A. Sutcliffe, Susan M. Ciotti, James R. Baker, JR.
Abstract: The disclosure provides compounds useful as insect repellents and compositions comprising such repellents. The disclosure further provides insect traps.
Type:
Application
Filed:
March 4, 2009
Publication date:
September 9, 2010
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Topically applicable pharmaceutical compositions contain at least one pharmaceutically active agent and an effective antimicrobial amount of a preservative excipient mixture and devoid of such amount of known preservative(s) as would otherwise itself impart an effective antimicrobial action thereto.
Abstract: A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
Type:
Grant
Filed:
July 29, 2005
Date of Patent:
August 31, 2010
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Stephanie M. Martin, Lei Huang, Shu-Ping Yang, Yanbin Huang, Julie Villanueva, Sharon Linda Greene, Kelly Arehart, Curtis Sayre, Robert B. Johnson
Abstract: Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.
Abstract: The present invention provides nanoparticulate policosanol, formulations including these particles, as a well as methods of using the particles and formulations for treatment and prophylaxis of various diseases and conditions.
Abstract: Antimicrobial compositions comprising organic acid esters and methods for reducing virus and/or bacteria populations using such compositions are provided. In one embodiment, an antimicrobial composition comprises a virucidally effective amount of an organic acid ester, the organic acid ester having a pKa1 value in the range of from about 3 to about 4.5. The composition further comprises a disinfecting alcohol present in an amount of 0 wt. % to about 75 wt. % and a carrier. The antimicrobial composition has a pH of no greater than about 5 at 25° C.
Type:
Application
Filed:
April 21, 2010
Publication date:
August 12, 2010
Applicant:
The Dial Corporation
Inventors:
Richard F. Theiler, Earl P. Seitz, JR., Janice L. Fuls
Abstract: This invention relates to compositions containing lower (C1-C4) alcohol and a polymeric fluorosurfactant formulated for being dispensed as a foam product. More particularly, the invention relates to improved compositions formulated with polymeric fluorosurfactants with pendant perfluoroalkyl side chains of a fully fluorinated chain length of C1-C7. The compositions also relate to use for personal care, such as skin sanitizing and cleansing.
Type:
Application
Filed:
April 2, 2010
Publication date:
July 29, 2010
Applicant:
The Clorox Company
Inventors:
David Lestage, David R. Scheuing, Scott L. Cumberland, Grant Templin
Abstract: This invention relates to compositions containing lower (C1-C4) alcohol and a polymeric fluorosurfactant formulated for being dispensed as a foam product. More particularly, the invention relates to improved compositions formulated with polymeric fluorosurfactants with pendant perfluoroalkyl side chains of a fully fluorinated chain length of C1-C7. The compositions also relate to use for personal care, such as skin sanitizing and cleansing.
Type:
Application
Filed:
April 2, 2010
Publication date:
July 29, 2010
Applicant:
The Clorox Company
Inventors:
David Lestage, David R. Scheuing, Scott L. Cumberland, Grant Templin
Abstract: A cosmetic process for caring for human skin, which is intended for preventing and/or combating at least one sign of ageing of the skin or the ‘orange peel’ appearance of the skin, includes the topical application to the skin of a composition containing at least one active agent for stimulating the expression of FN3K and/or FN3K RP. The use of this active agent for preventing and/or combating at least one sign of ageing of the skin or the ‘orange peel’ appearance of the skin associated with cellulite is also disclosed.
Type:
Application
Filed:
May 13, 2008
Publication date:
July 22, 2010
Applicant:
CHANEL PARFUMS BEAUTE
Inventors:
Christelle Lasserre, Elena Fedorova, Yannick Maestro
Abstract: Compositions containing 1,3-propanediol and an extraction product are provided, and the 1,3-propanediol in the composition is biologically derived. Also provided are processes for extracting an extract from a source. These processes include providing an ester of 1,3-propanediol and mixing the 1,3-propanediol ester with the source. This serves to extract the extract from the source into the ester. The processes also include separating the source from the ester and extract. Also provided are compositions containing an ester of 1,3-propanediol and an extraction product. In these compositions, the ester can have at least 3% biobased carbon.
Type:
Grant
Filed:
February 12, 2007
Date of Patent:
July 20, 2010
Assignee:
DuPont Tate & Lyle Bio Products Company, LLC
Inventors:
Melissa Joerger, Gyorgyi Fenyvesi, Raja Hari Prasad R. Poladi, Robert Miller
Abstract: The purpose of the present invention is to provide antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same, which enhance the antibacterial activity that 1,2-alkanediol originally have against a broad range of strains by compounding 1,2-alkanediol with 5-10 carbons and a certain fragrance component. The present invention relates to an antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same, which include 1,2-alkanediol with 5-10 carbons, and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and ?-pinene.
Type:
Grant
Filed:
September 25, 2003
Date of Patent:
July 13, 2010
Assignee:
Mandom Corporation
Inventors:
Aki Kobayashi, Hiroya Okamoto, Fumihiro Okada
Abstract: A composition and method are described for sanitizing or otherwise treating a material such as a non-living surface, living tissue, soil or atmosphere which may be contaminated by a toxin, chemical warfare agent, insect, prion, microorganism or other infectious agent. Also described are methods of making the composition.
Abstract: The present invention relates to the field of food industry, where it may be used for producing alcoholic products, to pharmacology for producing infusions tinctures and extracts or preparations containing aqueous-alcoholic solutions as pharmaceutically acceptable media and also to cosmetology for producing cosmetic products containing aqueous-alcoholic solutions as cosmetically acceptable media. In the proposed process for preparing an aqueous-alcoholic solution, separation of harmful admixtures takes place due to the preliminary protonation separately of water and alcohol prior to the formation of the aqueous-alcoholic solution, this leading to improvements in the physicochemical and organoleptic characteristics of the final product. The process not only provides the possibility of preparing alcoholic beverages of improved quality, but also to shorten the production cycle in the case of preparing some of them (by as much as two times and more) and, as a consequence, to cut down the product costs.
Abstract: This invention relates to a “high lower alcohol content” (>40% v/v of a C1-4 alcohol) liquid composition able to be either dispensed as a stable foam with the use of non-propellant foam dispensing devices from non-pressurized containers or as an alcohol gel composition which does not use thickener and gelling agents that leave undesirable deposits or a sticky after-feel and that has a final viscosity less than 4,000 cps. The liquid compositions comprise an alcohol, C1-4 (>40% v/v), a fluorosurfactant of at least 0.001% by weight to prepare a foamable composition or from 0-2.0% to prepare a gel-like composition of a final viscosity less than 4,000 cps, 0-10% w/w of additional minor components added to obtain the desired performance (a foamable composition or a gel-like composition with a viscosity less than 4,000 cps), and the balance being purified water.
Type:
Application
Filed:
February 24, 2010
Publication date:
June 24, 2010
Applicant:
DEB WORLDWIDE HEALTHCARE INC.
Inventors:
Bruce Michael Koivisto, Maria Teresa Fernandez de Castro
Abstract: An antimicrobial composition of 3-iodo-2-propynylbutyl carbamate (IPBC) and 1,3-butylene glycol (BG) as solvent, in a defined weight ratio, preferably 9-11% IPBC and 89-91% BG, and personal care formulations including the composition in an amount of about 0.1-0.2% therein, at a pH of 4-9, is described.
Type:
Grant
Filed:
May 23, 2006
Date of Patent:
June 22, 2010
Assignee:
ISP Investments Inc.
Inventors:
John J. Merianos, Paul Garelick, Susan M. Lindstrom
Abstract: The present invention relates to Periplaneta Americana or its ethanol extract for the treatment of inflammation. Specifically, said inflammation includes cervical erosion, ulcerative colitis, skin ulcer, mucosal ulcer and postoperative condyloma acuminatum. Treating said disorders by Periplaneta Americana or its ethanol extract has the advantages of effectively reducing bleeding, shortering healing time, significant curative effect, no adverse reactions and low cost. Periplaneta Americana or its ethanol extract provides a new selection for the clinical treatment of cervical erosion, ulcerative colitis and postoperative condyloma acuminatum.
Abstract: Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its preparation by solvent removal, lyophilization and precipitation with use of an anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin calcium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain mupirocin calcium anhydrate.
Abstract: The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I wherein Y, Q, Z, R, R1 and R2 are as defined in the specification. The present invention further comprises pharmaceutical compositions, e.g. ophthalmic compositions, including said compound of formula I.
Abstract: A composition and method for producing a beneficial effect on a subject's nerve associated with at least one of a cosmetic condition, a dermatological indication and a dental indication and another condition. The composition comprises a hydroxy-oligocarboxylic ester and is formulated for topical administration of the product to a subject to produce the beneficial effect. The method includes topically applying to the subject in a region where the beneficial effect is desired a hydroxy-oligocarboxylic ester in an amount effective to produce the beneficial effect.
Abstract: The present invention relates to a mixture, having a skin-tightening effect, which is made up of: 10 to 80% by weight of a polysaccharide, preferably of an alginate, having a molecular weight of less than 600,000 Daltons, preferably less than 400,000 Daltons and more preferably less than 200,000 Daltons, 15 to 75% by weight of a polyhydroxylated agent selected from sugars and their derivatives, particularly sugar esters and sugar ethers, preferably sorbitol, 3 to 15% by weight of poly(vinyl alcohol) or polyvinylpyrrolidone, and 0 to 25% by weight of cellulose or of a derivative of cellulose, such as carboxymethylcellulose or hydroxymethylcellulose. The present invention also relates to cosmetic compositions which contain this mixture. These cosmetic compositions enable a mechanical smoothing of the surface of the skin to be obtained progressively with great comfort of use and enables a good fixing of make-up products.
Type:
Grant
Filed:
August 27, 2002
Date of Patent:
April 20, 2010
Assignee:
LVMH Recherche
Inventors:
Hervé Delage-Grouiller, Brigitte Noe, Christian Mahe
Abstract: A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.
Abstract: An alcoholic foam composition, which can be dispensed as a foam via a pump-foam system contains a) at least 52 to ?99 wt % of an alcohol or mixture of alcohols, b) a surfactant or a surfactant mixture, c) at least one polyalkylene glycol, d) optionally, at least one foam stabilizer, e) optionally, at least one member selected from the group consisting of cosmetic auxiliaries, adjuvants, active ingredients, and mixtures thereof, and f) optionally water. The surface tension of component b) lies in the range of ±15 dyn/cm of the surface tension of component a) or corresponds to the surface tension of component a), and the sum of components a) to f) is 100 wt % relative to the total quantity of the foam composition.
Abstract: Compositions suitable for the control of pest amphibian species are described. More particularly, compositions for killing amphibians are described that comprise: (i) a xylenol compound or derivative according to formula (I) wherein R1, R2, R3, R4 and R5 are each independently selected from hydrogen, hydroxyl, halogen, —NH3 and C1-6 alkyl, and —R6—NH2, —R6—ONH2, —R6—NO2, and —R6—PO4, wherein R6 is C1-6 alkyl, and X is selected from hydrogen, halogen and C1-6 alkyl, or a salt thereof, and (ii) ethanol and optionally, (iii) methanol and/or at least one C3-6 alcohol. Methods for killing amphibians include contacting the amphibian with said compositions. Kits are described wherein said xylenol compounds and ethanol and optionally methanol and/or at least one C3-6 alcohol may be administered simultaneously or sequentially.
Abstract: 4-aminocyclohexanol compounds, processes for their preparation, pharmaceutical formulations comprising these compounds and the use of substituted 4-aminocyclohexanol compounds for the preparation of pharmaceutical formulations and for the treatment of diverse indications, including, without limitation, pain.
Type:
Grant
Filed:
January 16, 2004
Date of Patent:
March 16, 2010
Assignee:
Gruenenthal GmbH
Inventors:
Bernd Sundermann, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Stephan Wnendt
Abstract: This invention relates to a novel topical pharmaceutical composition. In particular, this invention is an overnight topical composition for treating cold sores.
Type:
Application
Filed:
December 3, 2007
Publication date:
March 11, 2010
Inventors:
Ranjan Ray Chaudhuri, Satish Ramchandra Dipali, Phillip E. West
Abstract: The antimicrobial acid-catalyzed coating composition of the invention is an acid-catalyzed coating composition formulated with at least one antimicrobial agent to provide antimicrobial activity to the coating composition and an article coated therewith.