Heterocyclic Monomer Patents (Class 514/772.5)
  • Patent number: 10793727
    Abstract: A low-specular-reflectance coating composition includes a binder, a solvent, and a plurality of substantially spherical particles having a multimodal particle size distribution. The multimodal particle size distribution has two or more modes, each mode having a peak defining an associated mode particle size, wherein the distribution function includes a first mode having a first peak corresponding to a first particle size, and a second mode having a second peak corresponding to a second particle size. A ratio of the second particle size to the first particle size is between 1.7-4.0. A smallest of the mode particle sizes is greater than or equal to 1.0 microns, and a largest of the mode particle sizes is greater than or equal to 3.0 microns.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: October 6, 2020
    Assignee: Eastman Kodak Company
    Inventor: Kevin D. Lofftus
  • Patent number: 10653802
    Abstract: Shown and described is a composition and a method to prepare a dopant-free photoluminescent hydrogel with synthetic polymers are disclosed. The hydrogel can be synthesized in one embodiment by incorporating an amino acid to a citric acid based polyester oligomer followed by multiple crosslinking group functionalization through a transesterification reaction using an enzyme such as Candida antarctica Lipase B (CALB) as a catalyst. The hydrogels are injectable, degradable, and their mechanical and photoluminescent properties are tunable. An in vivo study shows that the hydrogel emits strong fluorescence under visible light excitation and can completely degrade over time.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: May 19, 2020
    Assignee: New Jersey Institute of Technology
    Inventors: Xiaoyang Xu, Yunghao Tsou
  • Patent number: 10640732
    Abstract: Provided is a lens solution which has excellent lipid detergency, exhibits high hydrophilization performance, and exhibits an excellent lipid adhesion preventive effect and an excellent lubricity-imparting effect when the solution is used to coat a lens. Disclosed is a lens solution containing a polymer having 2.5% to 95% by mass of the following repeating unit (A) and 2.5% to 95% by mass of the following repeating unit (B): (A) a hydrophilic repeating unit; and (B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: May 5, 2020
    Assignees: JSR CORPORATION, JSR Life Sciences Corporation
    Inventors: Kazuhiro Iso, Satoshi Hyugaji
  • Patent number: 9255163
    Abstract: The present invention concerns a method for the dispersed phase polymerization of halogenated vinyl compounds, having the formula RbRcC?CX1X2, where: X1?F or CI, X2?H, F or CI, each of Rb and Rc, separately represents: —H, CI, F; or—an alkyl group, preferably chlorinated and/or fluorinated, and more advantageously perchlorinated or perfluorinated, comprising a step (E1) wherein said monomers are introduced into an aqueous phase together with—at least one source of free radicals; and—at least one reactive stabilizer comprising a polymer chain and a thiocarbonylthio-S group (C?S)—, said polymer chain comprising non-(N vinyl lactam)monomer units.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: February 9, 2016
    Assignee: Rhodia Operations
    Inventors: Mathias Destarac, James Wilson
  • Patent number: 9095496
    Abstract: The present invention relates to methods for producing particles of indomethacin using dry milling processes as well as compositions comprising indomethacin, medicaments produced using indomethacin in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of indomethacin administered by way of said medicaments.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: August 4, 2015
    Assignee: iCeutica Pty Ltd.
    Inventors: Aaron Dodd, Felix Meiser, Marck Norret, Adrian Russell, H. William Bosch
  • Publication number: 20150148431
    Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.
    Type: Application
    Filed: November 21, 2014
    Publication date: May 28, 2015
    Inventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
  • Patent number: 9023931
    Abstract: Oxidation-sensitive, low-peroxide polymer contained in a sealed, protective-gas-filled packaging form, comprising, per kilogram of polymer solid, at least one inorganic phosphorus compound in amounts such that the total phosphorus content is 2*10?5 to 0.02 mol, and methods for stabilizing oxidation-sensitive polymer against peroxide formation, wherein, during or after the polymerization, at least one inorganic phosphorus compound is added in one or more portions in amounts such that the total phosphorus content per kilogram of polymer solid content of the finished polymer is 2*10?5 to 0.02 mol, and the polymer treated in such a way is placed into a protective-gas filled, sealed packaging form, and also use of these polymers.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: May 5, 2015
    Assignee: BASF SE
    Inventor: Bernhard Fussnegger
  • Publication number: 20150104484
    Abstract: The present disclosure is directed to articles comprising a polyelectrolyte complex which stores mechanical strain and methods of forming articles comprising a polyelectrolyte complex which stores mechanical strain.
    Type: Application
    Filed: September 22, 2014
    Publication date: April 16, 2015
    Inventors: Joseph B. Schlenoff, Qifeng Wang
  • Patent number: 8980957
    Abstract: The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: March 17, 2015
    Assignee: CIS Pharma AG
    Inventors: Rolf Schäfer, Hans Hitz
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Patent number: 8962036
    Abstract: Disintegrable preparations of lanthanum carbonate prepared by co-precipitation, facilitating the manufacture of oral pharmaceutical dosage forms such as tablets, capsules, powders, granules, and sprinkles, and the use of such dosage forms to treat subjects with hyperphosphatemia are disclosed.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: February 24, 2015
    Assignee: Mylan Pharmaceuticals Inc.
    Inventors: Andrea Blum Works, John Twist, Okey Noe
  • Publication number: 20150045452
    Abstract: The present application provides an orally-disintegrating tablet having excellent tablet hardness and disintegrability. The present application further provides a method of producing a disintegrative particulate composition including three components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using granules obtained in the first wet granulation step and the remaining one component of the three components not used in the first wet granulation step. The production method may further includes a crystalline cellulose as a fourth component or a third step of mixing a crystalline cellulose into granules obtained in the second wet granulation step. Disintegrative particulate compositions obtained by these methods are also disclosed.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 12, 2015
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimko Ikeda, Haruka Wakayama
  • Publication number: 20150011657
    Abstract: The present invention concerns a method for preparing a polymer comprising a step (EI) for dispersed phase polymerization in the presence of a reactive stabiliser, wherein the following are brought into contact in an aqueous phase:—at least one ethylenically unsaturated monomer;—at least one source of free radicals; and—a reactive stabiliser comprising a polymer chain including monomer units (N-vinyl lactam) and a thiocarbonylthio-S group (C?S)—.
    Type: Application
    Filed: January 30, 2013
    Publication date: January 8, 2015
    Inventors: Mathias Destarac, James Wilson
  • Publication number: 20140370071
    Abstract: Disclosed are drug delivery systems comprising drugs admixed with polymers having drug solubility gradients and methods of making the polymers. Also disclosed are medical devices having coatings thereon comprising the drug solubility gradient-containing polymers and at least one drug.
    Type: Application
    Filed: August 29, 2014
    Publication date: December 18, 2014
    Inventors: Mingfei Chen, Peiwen Chen, Kishore Udipi
  • Patent number: 8912247
    Abstract: Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 16, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shanfeng Wang, Lichun Lu, Michael J. Yaszemski
  • Patent number: 8900610
    Abstract: Disclosed are compositions comprising a hydrophilic polymer, a hydrophobic polymer, a silver ion, and a chlorite anion, wherein the silver ion associates with at least one hydrophilic or hydrophobic polymer, and wherein the chlorite ion associates with the hydrophilic polymer. Also disclosed are methods of making a photo-stable silver ion and chlorite ion containing wound dressing and methods of reducing or preventing infection of a wound by using the compositions and wound dressings of the present invention.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: December 2, 2014
    Assignee: Southwest Research Institute
    Inventor: Stephen T. Wellinghoff
  • Publication number: 20140341957
    Abstract: A stable, aqueous composition containing a crosslinked, nonionic, amphiphilic polymer capable of forming a yield stress fluid in the presence of a surfactant is disclosed. The crosslinked, nonionic amphiphilic polymer is prepared by dispersion polymerization in the presence of a stabilizing polymer. The yield stress fluid is capable of suspending insoluble materials in the form of particulates and/or droplets requiring suspension or stabilization.
    Type: Application
    Filed: September 13, 2012
    Publication date: November 20, 2014
    Applicant: LUBRIZOL ADVANCED MATERIALS, INC.
    Inventors: Wei-Yeih Yang, Krishnan Chari, Shui-Jen Raymond Hsu, Prachur Bhargava
  • Patent number: 8883221
    Abstract: Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: November 11, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Guenter Bellmann, Gudrun Claus-Herz
  • Publication number: 20140322143
    Abstract: An adhesive composition is provided that is water-insoluble yet water-absorbent, i.e., capable of absorbing up to 15 wt. % water or more. The composition in composed of a film-forming hydrophilic polymer with at least one linear segment having a plurality of recurring polar groups along the polymer backbone, a complementary multifunctional polymer with a plurality of recurring functional groups that noncovalently bind to the polar groups on the film-forming polymer, and plasticizer. A method for manufacturing the adhesive composition is provided as well.
    Type: Application
    Filed: December 23, 2013
    Publication date: October 30, 2014
    Applicants: CORIUM INTERNATIONAL, INC., A.V. TOPCHIEV INSTITUTE OF PETROCHEMICAL SYNTHESIS, RUSSIAN ACADEMY OF SCIENCES
    Inventors: Mikhail M. Feldstein, Danir F. Bayramov, Mikhail Borisovich Novikov, Valery G. Kulichikhin, Nicolai A. Platè, Gary W. Cleary, Parminder Singh
  • Patent number: 8852640
    Abstract: Embodiments include a vehicle for delivery of nitric oxide comprising: a collection of micelles having an internal micelle core that comprises a polymer with N-diazeniumdiolate comprising NO complexed with secondary amines of the polymer. Embodiments include a method of making a nitric oxide vehicle comprising dissolving a polymer that comprises secondary amines in an aqueous solution and combining the polymer with nitric oxide in the solution to form a N-diazeniumdiolate comprising the nitric oxide complexed with the secondary amines, with the formation of the N-diazeniumdiolate causing the polymer to be at least partially insoluble in the solution and to form a collection of micelles that have an internal core that comprises N-diazeniumdiolate.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: October 7, 2014
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, Yun Suk Jo, André van der Vlies
  • Publication number: 20140294958
    Abstract: The present invention relates to lubricious coatings comprising an ionomer and a hydrophilic polymer wherein the ionomer is cross-linked using a suitable cross-linking agent, and optionally also conventional excipients, such as a surfactant, a plasticizer and/or a filler. The invention also relates to pharmaceutical products covered by such lubricious coatings, compositions for preparing these lubricious coatings and a method for providing pharmaceutical products with these lubricious coatings.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 2, 2014
    Inventors: Johannes Wilhelmus Belt, Yogesh Nathalal Gandhi
  • Publication number: 20140271521
    Abstract: A process for forming a personal care article, the process including (a) producing an extrudate from a twin screw extruder, and (b) forming the extrudate into the personal care article. The personal care article includes (i) from about 10% to about 60% of one or more anionic surfactants, wherein the one or more anionic surfactants have a Krafft point of less than 30° C.; (ii) from about 10% to about 50% of one or more water soluble polymers; (iii) from about 1% to about 30% of one or more plasticizers; and (iv) from about 10% to about 50% water.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Robert Wayne GLENN, JR., Todd Ryan THOMPSON, Ungyeong JUNG, Changwei ZHU, Alireza TABATABAEI-NAEINI
  • Patent number: 8835376
    Abstract: A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: September 16, 2014
    Assignee: Nanomaterials Technology Pte Ltd
    Inventors: Zhigang Shen, Jimmy Sung Lai Yun, Jun Hu, Nital Arvind Jugade, Jiyao Zhang, Wenhao Chen, Zhe Wang, Lingyan Gao, William Glover, Jian Feng Chen
  • Publication number: 20140256617
    Abstract: A hydrogel (I), comprising a polymer backbone wherein an aqueous solution of the hydrogel comprises a first lower critical solution temperature, and wherein the hydrogel is configured to be converted in vivo into a modified hydrogel, and wherein an aqueous solution of the modified hydrogel comprises a second lower critical solution temperature, and wherein the second lower critical solution temperature is greater than the first lower critical solution temperature.
    Type: Application
    Filed: October 12, 2012
    Publication date: September 11, 2014
    Inventors: Derek Overstreet, Brent Vernon, Ryan McLemore, Alex McLaren
  • Publication number: 20140242024
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
  • Publication number: 20140235727
    Abstract: The present invention relates generally to antimicrobial hydrogel polymers, and dressings comprising one or more hydrogel-forming hydrophilic polymers, where the hydrogels and dressings further comprise one or more antimicrobial agents that are released from the hydrogel in a controlled manner. The hydrogels and dressings may be used for medical, veterinary, and/or cosmetic applications. The dressings may be applied, for example, as wound dressings, surgical dressings, and percutaneous site dressings. In certain aspects of the invention, the dressings may be beneficially used in methods of accelerating wound healing, preventing and/or reducing the incidence of wound infection, and reducing scarring associated with wounds.
    Type: Application
    Filed: February 20, 2013
    Publication date: August 21, 2014
    Applicants: First Water Limited, CAREFUSION 2200, INC.
    Inventors: Scott A. TUFTS, Michael J. BALTEZOR, Moises ORTIZ, Jesus FLORES, Jennifer Raeder DEVENS, Hugh Semple MUNRO, Nicholas BOOTE
  • Publication number: 20140228451
    Abstract: A cationic pharmaceutically active ingredient containing composition is provided. The composition includes a cationic pharmaceutically active ingredient, a hydrophobic polymer/hydrophilic polymer adduct comprising a poly(vinylpyrrolidone/alkylene) polymer and a polymer comprising carboxylic acid groups, hydroxyl groups, or a mixture of carboxylic acid groups and hydroxyl groups, a compatibilizing amount of a long chain organic acid having a carbon chain of at least 8 carbon atoms, and at least about 50 wt. % water.
    Type: Application
    Filed: April 16, 2014
    Publication date: August 14, 2014
    Applicant: Skinvisible Pharmaceuticals, Inc.
    Inventors: James A. Roszell, Jie Zhang
  • Publication number: 20140213662
    Abstract: Polymeric porous particles have a continuous solid phase and at least two sets of discrete pores that are isolated from each other within the continuous phase and that have different average sizes. One set of discrete pores has a larger average size than another set of discrete pores by at least 50%. At least one set of discrete pores is free of detectably different marker materials. There porous particles can be prepared using evaporative limited coalescence techniques with especially chosen discrete pore stabilizing hydrocolloids to protect the pores during formation and to provide the different average sizes.
    Type: Application
    Filed: January 25, 2013
    Publication date: July 31, 2014
    Inventors: David Charles Boris, Teresa Joy Hosmer, Mridula Nair
  • Publication number: 20140206708
    Abstract: Disclosed herein are embodiments of a composition useful for treating and/or preventing dry eye disorders. The disclosed composition comprises components that maintain the composition's chemical and/or physical properties thereby providing a composition suitable for use.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 24, 2014
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Hong Ren, Thomas Sun
  • Publication number: 20140199232
    Abstract: Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
    Type: Application
    Filed: July 16, 2013
    Publication date: July 17, 2014
    Applicant: NANODERM SCIENCES, INC.
    Inventors: Richard A. Winchurch, Roy R. Yeoman
  • Publication number: 20140199250
    Abstract: Described are personal care compositions, comprising water, nonionic cellulose ethers having hydroxyethyl groups and being further substituted with one or more hydrophobic substituents, and at least one hair fixative polymer, moisturizer, conditioner, humectant, cationic conditioning polymer, antioxidant, anti-aging active, or sun care active.
    Type: Application
    Filed: September 14, 2012
    Publication date: July 17, 2014
    Applicants: UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC, ROHM AND HAAS COMPANY
    Inventors: Miao Wang, Emmett M. Partain
  • Publication number: 20140200278
    Abstract: A pharmaceutical dosage form comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric binder composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer, wherein at least 95% by weight of the vinylpyrrolidone homopolymer has a molecular weight distribution within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000. The dosage form is preferably prepared by a melt extrusion process. The polymeric carrier composition exhibits a high drug dissolution power and allows a reduction of the viscosity of the melt without deteriorating the mechanical properties and storage stability of the dosage form.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 17, 2014
    Applicant: Abbvie Deutschland GmbH & Co. KG
    Inventors: Bernd Liepold, Jörg Breitenbach, Markus Mägerlein, Claudia Henzel, Thomas K. Kessler
  • Publication number: 20140194535
    Abstract: The present invention generally relates to anhydrous emulsions containing an oil-soluble polar modified polymer and polylysine.
    Type: Application
    Filed: October 1, 2012
    Publication date: July 10, 2014
    Applicant: L'OREAL
    Inventors: Mikhail Motornov, Hy Si Bui, Jean-Thierry Simonnet, Christopher Pang
  • Publication number: 20140186427
    Abstract: The present invention pertains to oral applicable therapeutic dosage forms, in particular to orodispersible films. The present invention especially is directed to orodispersible films comprising a base layer substantially free of therapeutically active agents and a top layer comprising the desired therapeutically active agents. The present invention also concerns suitable base layers for such orodispersible films as well as therapeutical uses thereof and methods for manufacturing them.
    Type: Application
    Filed: August 13, 2012
    Publication date: July 3, 2014
    Applicant: TESA LABTEC GMBH
    Inventors: Armin Breitenbach, Sebastian Braun, Ralf Schliephacke
  • Publication number: 20140161797
    Abstract: The present invention relates generally to compositions and methods for administering a biologically active agent, and more specifically to injectable non-aqueous suspensions.
    Type: Application
    Filed: October 1, 2013
    Publication date: June 12, 2014
    Applicant: Durect Corporation
    Inventors: Guohua Chen, Paul R. Houston, Andrew Sheung-King Luk
  • Patent number: 8747896
    Abstract: A mucosal bioadhesive slow release carrier comprising an active principle and devoid of starch, lactose, which can release the active principal for a duration of longer than 20 hours. This bioadhesive carrier contains a diluent, an alkali metal alkylsulfate, a binding agent, at least one bioadhesive polymer and at least one sustained release polymer, as well as a method for its preparation.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: June 10, 2014
    Assignee: BioAlliance Pharma
    Inventors: Dominique Costantini, Caroline Lemarchand
  • Publication number: 20140155495
    Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.
    Type: Application
    Filed: November 21, 2013
    Publication date: June 5, 2014
    Applicant: PHOSPHAGENICS LIMITED
    Inventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
  • Publication number: 20140141978
    Abstract: A water miscible emulsion composition which is essentially free of long-chain alkylpyrrolidone and aromatic oil comprising: (i) a long chain substituted amide; (ii) a water insoluble film forming polymer; (iii) a water soluble anionic surfactant; and (iv) optionally, a bioactive, is particularly useful in providing water repellency and delaying the onset of fungi growth on crops and leaves.
    Type: Application
    Filed: July 10, 2012
    Publication date: May 22, 2014
    Applicant: ISP Investmentts Inc.
    Inventor: Kolazi S. Narayanan
  • Patent number: 8715632
    Abstract: Compositions for treating hair are disclosed. Methods of making and using compositions for treating hair are also disclosed.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: May 6, 2014
    Inventor: S. Katharine Presty
  • Publication number: 20140121280
    Abstract: A dental composition comprising: a) about 1 to about 80% by weight of particulate material including: (i) calcium silicate, calcium aluminate, tetracalcium aluminoferrite, calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, or mixtures thereof; and b) about 1 to about 50% by weight liquid carrier including: (i) water-soluble polymer, (ii) surfactant, the surfactant is selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and sarcosinates, and mixtures thereof; and (iii) water; wherein the particulate and liquid carrier being mixed together to form a hydrate gel material that can harden.
    Type: Application
    Filed: January 7, 2014
    Publication date: May 1, 2014
    Applicant: DENTSPLY International Inc.
    Inventors: Carolyn M. Primus, James L. Gutmann, Miklos M. Breuer, Steven R. Jefferies
  • Publication number: 20140107226
    Abstract: Disclosed herein are methods of enhancing the stability of a sustained pharmaceutical composition comprising an active agent and a polymer and methods of preparing such pharmaceutical compositions with enhanced stability.
    Type: Application
    Filed: December 18, 2013
    Publication date: April 17, 2014
    Applicant: A.P. PHARMA, INC.
    Inventors: Devang T. Shah, John Barr
  • Publication number: 20140105975
    Abstract: The present invention relates to novel coating compositions for application to solid dosage forms such as tablets or caplets, solid dosage forms coated with the composition, and methods of preparing said coating compositions.
    Type: Application
    Filed: September 13, 2013
    Publication date: April 17, 2014
    Applicant: Capsugel Belgium NV
    Inventors: Robert Anthony Scott, Dominique Cade, Frederic Hoehn, Ewart Thomas Cole
  • Publication number: 20140086854
    Abstract: The invention relates to water-soluble or water-swellable polymers that contain a) 20.0 to 98.97 mole-% of one or more repeating structural units originating from special monomers with sulfonic acid groups or the salts thereof such as e.g. 2-acrylamido-2-methyl-propanesulfonic acid or the salts thereof, b) 1.0 to 60.0 mole-% of one or more repeating structural units containing an amide group and d) 0.01 to 8.0 mole-% of one or more repeating structural units originating from special crosslinking agents with at least three polymerizable double bonds. The polymers for example have an advantageous sensory property profile and are highly suitable as thickening agents even in salt-containing compositions. They are furthermore advantageously suitable for producing cosmetic, dermatological or pharmaceutical compositions.
    Type: Application
    Filed: March 3, 2012
    Publication date: March 27, 2014
    Applicant: CLARIANT FINANCE (BVI) LIMITED
    Inventors: Peter Klug, Dirk Fischer, Thomas Lindner, Wiebke Mueckenheim, Bianca Brasch, Michael Hornung
  • Patent number: 8658703
    Abstract: Addition of polyvinylpyrrolidone and a water-soluble anionic macromolecular compound to an aqueous suspension of a hardly soluble drug allows to provide an aqueous suspension in which aggregation of drug particles, formation of macro crystals from suspended particles and formation of secondary particles from deposited particles are prevented, and adhesion and adsorption to containers made of plastics, e.g., polypropylene or polyethylene, are avoided. As it has a good redispersibility, the aqueous suspension is useful as eye drops, nasal drops, ear drops, injections, oral preparations, liniments and lotions.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: February 25, 2014
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventor: Shirou Sawa
  • Publication number: 20140038996
    Abstract: The present invention relates to a freeze-dried (also called lyophilized) drug nanosuspension. The present freeze-dried drug nanosuspension composition has an acceptable stability of the particle size distribution during storage, including long term storage.
    Type: Application
    Filed: April 13, 2012
    Publication date: February 6, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Sabine Karine Katrien Inghelbrecht, Jakob Andreas Beirowski, Henning Gieseler
  • Publication number: 20140005135
    Abstract: Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 ?l to 3 ml.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 2, 2014
    Applicant: XERIS PHARMACEUTICALS, INC.
    Inventors: Steven J. Prestrelski, Nancy Scott
  • Publication number: 20130338121
    Abstract: The present document describes a monolithic tablet dosage form for delivery of an active ingredient at two different release rates comprising a carboxyl polymer complexed with a multivalent cation and a disintegrating agent for a first initial fast release of the active ingredient, and a modulating agent for a second sustained release of the active ingredient. Also described are processes for preparing the carboxyl polymer complexed with a multivalent cation, and carboxyl polymer made from the process.
    Type: Application
    Filed: February 28, 2012
    Publication date: December 19, 2013
    Inventors: Le Tien Canh, Mircea-Alexandru Mateescu
  • Publication number: 20130315846
    Abstract: Disclosed are compositions and methods for their use that can be used indivisually or in combination in a regimen format. The compositions have the ability to treat a wide range of skin conditions.
    Type: Application
    Filed: May 22, 2013
    Publication date: November 28, 2013
    Applicant: MARY KAY INC.
    Inventors: Julia Collier, Milagros Sanchez, Amit Patel, Wanli Zhao, Patricia Jacoby, Tiffany Florence, Michelle Hines, David Gan
  • Publication number: 20130303630
    Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
    Type: Application
    Filed: July 15, 2013
    Publication date: November 14, 2013
    Inventors: Chris Brough, James W. McGinity, Dave A. Miller, James C. DiNunzio, Robert O. Williams, III
  • Publication number: 20130281546
    Abstract: An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 ?m, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
    Type: Application
    Filed: January 17, 2013
    Publication date: October 24, 2013
    Applicant: Kyowa Hakko Kirin Co., Ltd.
    Inventor: Kyowa Hakko Kirin Co., Ltd.