Polymer From Ethylenic Monomers Only Patents (Class 514/772.4)
  • Patent number: 10245348
    Abstract: Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) providing said first component and said second component in a combined form in a final container, c1) either by filling said first component and said second component into said final container so as to obtain a dry mixture in said final container, c2) or by providing said first component or said second component in said final container and adding said second component or said first component so as to obtain a combination of said first component with said second component in said final container, d) finishing the final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: April 2, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Andreas Goessl, Atsushi Edward Osawa, Cary J. Reich
  • Patent number: 10227548
    Abstract: Provided is a composition, notably a fabric conditioning composition, comprising (a) a quaternary ammonium compound; (b) a cationic polysaccharide; (c) a first non-ionic polysaccharide; and (d) a second non-ionic polysaccharide, wherein the second non-ionic polysaccharide is different from the first non-ionic polysaccharide and the second non-ionic polysaccharide has a Molar Substitution (MS) in the range of 0.2 to 1.8.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 12, 2019
    Inventors: Hai Zhou Zhang, Lin He, Da Wei Jin, Nikolay Christov, Galder Cristobal
  • Patent number: 10207028
    Abstract: Compositions having a drug-loaded microparticle and bone cement and methods of making such compositions are disclosed. Also disclosed are methods of employing such compositions for the treatment of injected joint spaces and bone disease.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: February 19, 2019
    Assignee: Loma Linda University
    Inventors: Victoria Maskiewicz, Gary Botimer, Serkan Inceoglu
  • Patent number: 10160854
    Abstract: A dual reactivity crosslinking agent of formula I having at least two different reactive sites, and hydrogel materials prepared from at least two monomers with different rates of free-radical polymerization reactivity. The crosslinking agent includes at least one free-radical reactive site for vinyl-containing monomer and at least one free-radical reactive site for meth(acrylic)-containing monomer. The hydrogel materials are useful in the manufacture of biocompatible medical devices, for example, hydrogel materials having desirable physical properties useful as contact lens materials.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: December 25, 2018
    Assignee: GL Chemtec Vision Inc.
    Inventors: Gamil Alhakimi, Lisa H. Studnicki, Jay F. Kunzler
  • Patent number: 10155897
    Abstract: Hydrophobically and hydrophilically modified polysaccharides and methods of using the same for treatment of a subterranean formation. A method of treating a subterranean formation. The method includes obtaining or providing a composition including a hydrophobically and hydrophilically modified polysaccharide (HHMP). The method includes placing the composition in a subterranean formation.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: December 18, 2018
    Assignee: Hilliburton Energy Services, Inc.
    Inventor: Ali Alwattari
  • Patent number: 10092580
    Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: October 9, 2018
    Assignees: OTONOMY, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jay Lichter, Benedikt Vollrath, Sergio G. Duron, Carl Lebel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Andrew M. Trammel, Michael Christopher Scaife, Jeffrey P. Harris
  • Patent number: 10035143
    Abstract: A cross-linked anionic polyelectrolyte resulting from the polymerization, for 100 mol %: (i) of a proportion no smaller than 30 mol % and smaller than 99.5 mol % monomer units from a monomer having a partially or totally salified strong acid function; (ii) of a proportion no smaller than 0.5 mol % and no greater than 5 mol % monomer units from at least one monomer having Formula (I): CH2?CH(CH3)—C(=0)—OR1 (I), wherein Ri is an alkyl radical including 6 to 18 carbon atoms; (iii) of a proportion greater than 0 mol % and no greater than 5 mol % monomer units from at least one diethylene or polyethylene cross-linking monomer; and (iv) optionally, of a proportion smaller than 69.5 mol % monomer units from a neutral monomer. Also, a method for preparing the polyelectrolyte and to the use thereof as a thickener in topical compositions.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: July 31, 2018
    Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMQUES SEPPIC
    Inventors: Olivier Braun, Paul Mallo
  • Patent number: 9775908
    Abstract: The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: October 3, 2017
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Endre Mikulásik, Patrik Fazekas
  • Patent number: 9757313
    Abstract: A cosmetic or dermatological compositions of oil-in-water emulsion type, including, in a physiologically acceptable medium, at least gemini surfactant of formula (I): in which R1 and R3 denote, independently of one another, an alkyl radical containing from 1 to 25 carbon atoms; R2 denotes a spacer consisting of a linear or branched alkylene chain containing from 1 to 12 carbon atoms; X and Y denote, independently of one another, a group —(C2H4O)a—(C3H6O)bZ; n ranges from 1 to 10, in combination with an effective amount of at least one semi-crystalline polymer which is solid at ambient temperature and which has a melting point below 70° C., said polymer having a number-average molecular mass greater than or equal to 2000, said emulsion having a proportion of fatty phase of greater than 10% by weight relative to the total weight of the composition and including more than 40% by weight of non-volatile oil(s) relative to the weight of the fatty phase.
    Type: Grant
    Filed: September 17, 2008
    Date of Patent: September 12, 2017
    Assignee: L'OREAL
    Inventor: Raluca Lorant
  • Patent number: 9592196
    Abstract: Methods and materials useful for applying pharmacologic agents to the ear are described. The methods involve delivering a composition that contains at least one viscogenic agent and at least one pharmacologic agent to the epidermal surface of the tympanic membrane via the ear canal. The composition is delivered to the tympanic membrane in a flowable form and, after delivery to the tympanic membrane, becomes sufficiently viscous such that the pharmacologic agent is localized against the tympanic membrane. Such compositions can be used to prophylactically and/or therapeutically treat middle and inner ear conditions, including otitis media.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: March 14, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: Ronald J. Sawchuk, Belinda W. Y. Cheung
  • Patent number: 9513406
    Abstract: Disclosed embodiments concern a soluble functionalized nanoparticle suitable for use with polymerizable components, such as monomers (or polymers thereof), used to make gradient optical polymer nanocomposites. In particular disclosed embodiments, the nanoparticle is functionalized with one or more surface ligands that promote the solubility and dispersion of the nanoparticle in the disclosed monomer. Also disclosed herein are embodiments of a method for making the functionalized nanoparticle as well as embodiments of a composition comprising the functionalized nanoparticles.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: December 6, 2016
    Assignee: University of Oregon
    Inventors: Richard Chartoff, Casey Check
  • Patent number: 9447089
    Abstract: Provided are solid dispersions, solid molecular complexes, salts and crystalline polymorphs involving propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: September 20, 2016
    Assignees: Plexxikon Inc., Hoffman-La Roche Inc.
    Inventors: Dipen Desai, Ralph Diodone, Zenaida Go, Prabha N. Ibrahim, Raman Iyer, Hans-Juergen Mair, Harpreet K. Sandhu, Navnit H. Shah, Gary Visor, Nicole Wyttenbach, Stephan Lauper, Johannes Pudewell, Frank Wierschem
  • Patent number: 9320273
    Abstract: The invention relates to an extract of Euodia suaveolens Scheff. The invention is characterized in that the extract is obtained from the airborne portions of the plant by means of at least one extraction step using an organic or hydro-alcoholic solvent, and in that it comprises evodone at a concentration of between 0.1 and 35% by weight of the total weight of the extract, and in that it has an insect repellent activity. The invention also relates to a repellent composition, characterized in that it comprises, in a cosmetically acceptable medium, evodone at a concentration of between 0.1 and 25% by weight of the total weight of the composition, and to the use of evodone as an active agent for repelling insects, in particular mosquitoes and more particularly the European/Mediterranean mosquitoes of the Aedes aegypti species.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: April 26, 2016
    Assignee: CHARABOT
    Inventors: Marina Humbert, Sophie Lavoine-Hanneguelle
  • Patent number: 9259405
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound famciclovir and a therapeutically-effective amount of the COX-2 inhibitor diclofenac. The invention is further related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of famciclovir and diclofenac.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: February 16, 2016
    Assignee: INNOVATIVE MED CONCEPTS, LLC
    Inventor: William L. Pridgen
  • Patent number: 9259350
    Abstract: Contact lenses comprising phosphorylcholine groups release beneficial polyionic or guanidinium-containing agents.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 16, 2016
    Assignee: CooperVision International Holding Company, LP
    Inventors: Victoria Rogers, Andrew Luk, Arthur Back, Samuel Zalipsky
  • Patent number: 9243080
    Abstract: The present invention aims to provide a method of producing a PTFE aqueous dispersion which contains PTFE particles having a small particle size and which is excellent in dispersion stability by multistage polymerization without using a long-chain fluorosurfactant. The method includes the steps of: (1) polymerizing a fluoromonomer in an aqueous medium in the presence of a fluorosurfactant and a polymerization initiator to provide an aqueous dispersion containing particles of at least one fluoropolymer selected from the group consisting of PTFE and melt-processible fluororesins excluding polytetrafluoroethylene; and (2) polymerizing TFE alone or TFE and a modifying monomer in an aqueous medium in the presence of the fluoropolymer particles and a polymerization initiator to provide an aqueous dispersion containing PTFE particles. The fluoropolymer particles have an equivalent weight (EW) of 6,000 or more and a volume average particle size of not smaller than 0.1 nm but smaller than 20 nm.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: January 26, 2016
    Assignee: DAIKIN INDUSTRIES, LTD.
    Inventor: Yoshinori Nanba
  • Patent number: 9050369
    Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: June 9, 2015
    Assignee: ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Atsuko Nakata, Eri Matsumoto
  • Publication number: 20150141517
    Abstract: Provided is a rapid release tablet excellent in binding capability and disintegrability and also excellent in storage stability and the like. More specifically, provided are a granulated composite comprising low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight and D-mannitol, wherein the D-mannitol contains 0.9% by weight or less of D-sorbitol; a rapid release tablet comprising the granulated composite and a drug; and a method for producing a granulated composite comprising the steps of: mixing low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight, first D-mannitol, and water to obtain an aqueous dispersion, and granulating while adding the aqueous dispersion to second D-mannitol, wherein the first D-mannitol and the second D-mannitol contain 0.9% by weight or less of D-sorbitol in total.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 21, 2015
    Inventors: Yasuyuki Hirama, Naosuke Maruyama
  • Publication number: 20150132346
    Abstract: A macroparticle pigment powder and methods of making the same. The macroparticle pigment powder comprises a plurality of macroparticle particles. The macroparticles are comprised of a matrix material that include pigment particles. In some embodiments the matrix material is polymeric in nature and selected from the group consisting of a natural latex, acrylics, polyacrylate, polymethacrylate, polyurethane, polyvinyl acetate, styrene-butadiene rubber, acrylonitrile butadiene styrene copolymer, and combinations thereof.
    Type: Application
    Filed: May 19, 2014
    Publication date: May 14, 2015
    Inventors: Yun Shao, Pascal Delrieu, David Schlossman, Frank Mazzella
  • Publication number: 20150104513
    Abstract: A coating film comprising ethyl cellulose as a component A and an (ethyl acrylate)-(methyl methacrylate) copolymer or a plasticized vinyl acetate polymer as a component B, and having a tensile elongation of 150% or more and a tensile strength of 9 N or more.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 16, 2015
    Applicant: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Naoya YOSHIDA, Kazuhiro OBAE
  • Publication number: 20150099635
    Abstract: An agricultural oil-based suspension formulation comprising an active ingredient suspended in finely divided form in an oil and at least one unsaturated rubber-type copolymer or a mixture thereof, wherein the rubber-type copolymer comprises at least styrene as a residue.
    Type: Application
    Filed: June 8, 2012
    Publication date: April 9, 2015
    Inventors: Andrew David Holliday, Dilek Saylik, Rowan Brown, Karen Vab Der Sande, Andrew F. Kirby, Robert E. Bohun
  • Publication number: 20150098915
    Abstract: Disclosed is a self-reversible reverse latex including: a) 25-80% by mass of a cross-linked anionic polyelectrolyte (P), resulting from the polymerisation, for 100 mole percent: i)—of a molar proportion 30% and 95% of monomeric units from at least one monomer including a free, partially- or totally-salified strong acid function; and ii)—of a molar proportion >0% and <5% of at least one monomer with diethylenic or polyethylenic crosslinking; b) 0.5-10% by mass of a terpolymer of stearyl methacrylate, pentacosaethoxylated behenyl methacrylate and N,N-dimethylacrylamide, resulting from the polymerisation, for 100 mole percent: of 80-95 mole percent of stearyl methacrylate, of 2.5-10 mole percent of N,N-dimethylacrylamide, and of 2.5-10 mole percent of pentacosaethoxylated behenyl methacrylate, c) 5-40% by mass of at least one oil, and d) 0.1-40% by mass of water; method of preparing same and use thereof as a thickener.
    Type: Application
    Filed: May 29, 2013
    Publication date: April 9, 2015
    Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Paul Mallo, Olivier Braun
  • Patent number: 8999358
    Abstract: The present invention relates to aqueous insecticidal preparations in the form of an aqueous dispersion of finely divided polymer particles which comprise at least one insecticidal organic active ingredient with a solubility in water of not more than 5 g/l at 25° C. at 1013 mbar and which have a mean particle size, determined by dynamic light scattering, of not more than 300 nm, where the polymer particles which comprise the at least one insecticidal active ingredient of a cationic surface charge and where the aqueous dispersion of the active-ingredient-comprising polymer particles is obtainable by subjecting a monomer composition of ethylenically unsaturated monomers M, in which the ethylenically unsaturated monomers M comprise the at least one insecticidal active ingredient in dissolved form, to radical aqueous emulsion polymerization.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: April 7, 2015
    Assignee: BASF Aktiengesellschaft
    Inventors: Patrick Amrhein, Gunnar Kleist, Dirk Haentzschel, Joerg Habicht, Holger Schöpke
  • Patent number: 8999305
    Abstract: The invention relates to a composition comprising (1) at least one polar modified polymer, (2) at least one compound selected from a hyperbranched polyol having at least two hydroxyl groups, a sugar silicone surfactant, and a gelling agent.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: April 7, 2015
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Mohamed Kanji, Anita Chon Tong, Chunhua Li, Susan Halpern, Bruno Thierry Bavouzet
  • Patent number: 8992988
    Abstract: A coating film comprising ethyl cellulose as a component A and an (ethyl acrylate)-(methyl methacrylate) copolymer or a plasticized vinyl acetate polymer as a component B, and having a tensile elongation of 150% or more and a tensile strength of 9 N or more.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: March 31, 2015
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Naoya Yoshida, Kazuhiro Obae
  • Patent number: 8980956
    Abstract: A method for producing polymerizable solution which comprises dissolving an ethylenically unsaturated zwitterionic monomer in a co-monomer system comprising a functionalized ethylenically unsaturated monomer in which the zwitterionic monomer is soluble, a siloxane group-containing monomer or macromer, and a crosslinking agent is disclosed. The polymerizable solution is biocompatible and can be used to produce polymers and articles such as contact lenses.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 17, 2015
    Assignee: Vertellus Specialities Inc.
    Inventors: Michael Driver, Qingpu Hou, Jin Hai Wang
  • Patent number: 8980957
    Abstract: The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: March 17, 2015
    Assignee: CIS Pharma AG
    Inventors: Rolf Schäfer, Hans Hitz
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Publication number: 20150057369
    Abstract: The invention relates to alkoxylation products, their preparation, compositions comprising the alkoxylation products of the invention, and the use thereof as or for producing adhesives and sealants.
    Type: Application
    Filed: July 16, 2014
    Publication date: February 26, 2015
    Inventors: Michael Ferenz, Matthias Lobert, Frank Schubert, Anke Lewin, Volker Zellmer, Wilfried Knott, Melanie Roessing, Stephan Roessing
  • Patent number: 8962697
    Abstract: The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: February 24, 2015
    Assignee: Interface Biologics Inc.
    Inventors: Frank Laronde, Hanje Chen
  • Publication number: 20150024052
    Abstract: The present invention generally relates to nitric oxide releasing pharmaceutical compositions and methods of using the same.
    Type: Application
    Filed: February 28, 2013
    Publication date: January 22, 2015
    Applicant: Novan, iNC.
    Inventor: Ryan Doxey
  • Patent number: 8936802
    Abstract: The present invention relates to a molded article which is shaped of a polymer composition comprising 100 parts by weight of an olefin-based polymer, and 0.01 to 100 parts by weight of a C10-90 saturated chain hydrocarbon and/or liquid paraffin and 0.01 to 200 parts by weight of a releasable active compound per 100 parts by weight of said olefin-based polymer, and which is drawn at a draw ratio of 2 or more.
    Type: Grant
    Filed: December 25, 2009
    Date of Patent: January 20, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Shizuto Yamakoshi
  • Publication number: 20150017110
    Abstract: The present invention describes, in one aspect, the use of two oppositely charged surfactants as the primary emulsifiers in two separated parts of a product. The emulsifiers are chosen such that when the two parts of the emulsion product are mixed, the emulsifiers react to form water insoluble compounds that are no longer able to function as emulsifiers, thus, the oil phase of the emulsion is precipitated onto the skin along with the emulsifier reaction product. Since none of the deposited materials are water soluble, or capable of functioning as emulsifiers, the deposited oil phase is extremely resistant to being washed off. This technology finds applications in hand and body creams and lotions, baby care products, sunscreens, skin protective products, makeup systems, and automotive and furniture polishes.
    Type: Application
    Filed: October 2, 2014
    Publication date: January 15, 2015
    Inventor: John C. Carson
  • Publication number: 20140378554
    Abstract: A water-in-oil microemulsion, including a polyacrylamide, a fatty acid, a surfactant, an oil continuous phase, and an aqueous discontinuous phase in the oil continuous phase. The fatty acid includes a tall oil fatty acid, oleic acid, or a combination of a tall oil fatty acid and oleic acid. The water-in-oil microemulsion contains 6 to 48 parts by weight of the polyacrylamide, 30 to 62 parts by weight of the fatty acid, and 20 to 44 parts by weight of the surfactant per 100 parts by weight of the polyacrylamide, the fatty acid, and the surfactant combined.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Franklin E. Sexton, Ryan T. Strash, Todd J. O'Connell
  • Patent number: 8912247
    Abstract: Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: December 16, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shanfeng Wang, Lichun Lu, Michael J. Yaszemski
  • Patent number: 8906403
    Abstract: A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inclusion complex(es) and/or cyclodextrin derivative inclusion complex(es), at least one poly(carboxylic) acid, and optionally a catalyst; b) heating at a temperature between 100° C. and 200° C. for a period of 1 to 60 minutes; c) washing with water; d) drying, wherein at least one bioactive agent is incorporated in the biomaterial by impregnation of the biomaterial after the drying step in a concentrated solution of the bioactive agent.
    Type: Grant
    Filed: November 15, 2005
    Date of Patent: December 9, 2014
    Assignees: Universite des Sciences et Technologies de Lille SAIC, Universite de Droit et Sante
    Inventors: Bernard Martel, Nicolas Blanchemain, François Boschin, Stephan Haulon, Elisabeth Delcourt Debruyne, Michel Morcellet, Hartmut Friederich Hildebrand
  • Patent number: 8901101
    Abstract: The present invention provides membrane lytic poly(amido amine) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 2, 2014
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Marina Busuek, Rubina G. Parmar, Michael Steven Poslusney, Weimin Wang, J. Michael Williams
  • Publication number: 20140348887
    Abstract: A stable, aqueous composition containing a crosslinked, nonionic, amphiphilic polymer capable of forming a yield stress fluid in the presence of a surfactant is disclosed. The yield stress fluid is capable of suspending insoluble materials in the form of particulates and/or droplets requiring suspension or stabilization.
    Type: Application
    Filed: September 13, 2012
    Publication date: November 27, 2014
    Applicant: Lubrizol Advanced Materials, Inc.
    Inventors: Shui-Jen Raymond Hsu, Krishnan Chari, Wei-Yeih Yang, Prachur Bhargava, Murat Kadir
  • Publication number: 20140350125
    Abstract: An oil-in-water emulsion includes: 5 to 55 wt % of an oil phase consisting of at least one oil and/or one wax; 0.06 to 4.5 wt % of at least one cross-linked anionic polyelectrolyte resulting from the polymerization of at least one monomer having a strong acid function, the monomer being partially or totally salified 2-methyl 2-[(1-oxo 2-propenyl)amino] 1-propanesulfonic acid, with at least one neutral monomer selected from the N,N-dialkyl acrylamides, wherein each of the alkyl groups include between one and four carbon atoms, and at least one monomer of formula (I), where R is a straight or branched alkyl radical including eight to twenty carbon atoms and 1?n?20, in the presence of at least one cross-linking agent; and 0.0025 to 1 wt % of xanthan gum; 0.0025 to 1 wt % acacia gum; 38.5 to 94.835 wt % of a cosmetically acceptable aqueous phase.
    Type: Application
    Filed: December 5, 2012
    Publication date: November 27, 2014
    Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventor: Emmanuelle Merat
  • Publication number: 20140350126
    Abstract: A linear, branched or cross-linked anionic polyelectrolyte, resulting from the polymerisation, for 100 molar percentage: a) 50% to 99% of monomeric units including a strong, free and partially or completely salified acid function ; b) 1% to 50% of a monomeric units of formula (I): CH2?CH(R1)-C(=0)-0-(CH2)n-CF3 (I), wherein R1 represents H or CH3, and n is 1, 2 or 3; c) optionally greater than 0% to 5% of monomeric units of formula (II): R2-C(=0)-0-[(CH2-CH(R4)-0]m-R3 (II), wherein m is 0 to 50, R2 represents an unsaturated aliphatic monovalent radical with 2 to 4 carbon atoms, R4 represents H, CH3 or CH3CH2 and R3 represents a linear or branched, saturated or unsaturated hydrocarbon aliphatic radical with 8 to 30 carbon atoms, and d) optionally greater than 0% to 5% of at least one monomer with diethylenic or polyethylenic cross-linking. The use thereof as a thickener in topical compositions.
    Type: Application
    Filed: January 16, 2013
    Publication date: November 27, 2014
    Applicant: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC
    Inventors: Olivier Braun, Paul Mallo
  • Publication number: 20140343169
    Abstract: The present invention is an oil-in-water emulsified skin cosmetic comprising acetylated hyaluronic acid, a specific polymethacryloyloxyethyl phosphorylcholine derivative, non-emulsifying cross-linked silicone, glycerin, polyvinyl alcohol, an acrylamide type thickener, and an oil component in an amount of 25 wt % or more relative to the total amount of the oil-in-water emulsified skin cosmetic. The object of the present invention is to provide an oil-in-water emulsified skin cosmetic manifesting superior effects in improving spreadability on the skin, absorption in the skin, absence of stickiness, emollient sensations, taut sensations, and wrinkles/sagging.
    Type: Application
    Filed: November 22, 2012
    Publication date: November 20, 2014
    Applicant: SHISEIDO COMPANY, LTD.
    Inventor: Takayuki Omura
  • Publication number: 20140343170
    Abstract: The present invention provides a corona-core microgel emulsifying agent composed of a copolymer obtained by polymerizing polyethylene oxide macromonomers, hydrophobic monomers, and cross-linking monomers under specific conditions as well as an oil-in-water emulsified composition characteristically using said emulsifying agent for emulsification. The object of the present invention is to provide a new corona-core microgel emulsifying agent to be used to prepare an oil-in-water emulsified composition that manifests superior emulsification stability, stability over time, and low skin irritation, and is free of stickiness at the time of application, manifests dewy freshness, is free of powdery sensation and/or squeakiness, and is superior in durability of fragrance, as well as an oil-in-water emulsified composition emulsified with said emulsifying agent.
    Type: Application
    Filed: October 17, 2012
    Publication date: November 20, 2014
    Applicant: SHISEIDO COMPANY, LTD.
    Inventors: Yuki Sugiyama, Tomoko Sato, Ken Shoji
  • Patent number: 8889109
    Abstract: The present invention provides novel solid pharmaceutical dosage forms for oral administration, after being constituted in water. The solid dosage forms comprise a therapeutically effective amount of valganciclovir hydrochloride and a non-hygroscopic organic acid present in an amount sufficient to stabilize the valganciclovir hydrochloride in a predetermined amount of water. The present invention also provides novel liquid pharmaceutical dosage forms for oral administration after constituting the solid pharmaceutical dosage form with water. A non-hygroscopic bulking agent may optionally be included in the above dosage form. These novel pharmaceutical dosage forms are useful in the treatment or control of viruses such as herpes simplex virus and cytomegalovirus. The present invention also provides a method for treating these diseases employing the solid and liquid pharmaceutical dosage forms and a method for preparing these pharmaceutical dosage forms.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: November 18, 2014
    Assignee: Hoffman-La Roche Inc.
    Inventors: Maria Oksana Bachynsky, Martin Howard Infeld, Navnit Hargovindas Shah
  • Patent number: 8889791
    Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers and degradation products thereof are non-toxic and typically have an LCST between room temperature and 37° C. so that they are liquid at room temperature and gelled at 37° C. which facilitates their use in humans, for example for wound treatment and as a cellular growth matrix or niche. The copolymer comprises numerous ester linkages in its backbone so that the copolymers are erodeable in situ. Degradation products of the polymer are soluble and non-toxic. The copolymer is amine-reactive so that it can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymer.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: November 18, 2014
    Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
    Inventors: Jianjun Guan, William R. Wagner, Kazuro Lee Fujimoto
  • Publication number: 20140335182
    Abstract: The present invention relates to a process for preparing an aqueous polymer dispersion by free-radical emulsion polymerization of a monomer mixture which comprises N,N-diethylaminoethyl methacrylate, to the polymer dispersion obtainable by this process, and to the use thereof.
    Type: Application
    Filed: July 28, 2014
    Publication date: November 13, 2014
    Inventors: Maximilian Angel, Karl Kolter, Hartwig Voß
  • Publication number: 20140335035
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a particulate benefit agent.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray WHITELY, Sherrie Ann JORDAN
  • Publication number: 20140335032
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a hydroxyl functional organic species and is substantially free of silica particles.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Publication number: 20140335034
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a preservative.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Publication number: 20140335033
    Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a perfume.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
  • Patent number: 8883221
    Abstract: Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: November 11, 2014
    Assignee: Bausch & Lomb Incorporated
    Inventors: Guenter Bellmann, Gudrun Claus-Herz