Abstract: Solid compositions of certain cholinergic compounds are stabilized in starch. Especially compositions of corn starch combined or mixed with the 0-substituted-1,2,5,6-tetrahydro-3-pyridine oxime ether, CI-979 HCl, a cognition activator, have been found stable in a heated environment of up to 60.degree. C. over 17 days such that no losses were detected by HPLC analysis. A solid peroral pharmaceutical formulation for the treatment of cognitive disorders is based on the bicomponent composition of active ingredient and stabilizer using appropriate amounts of other excipients or components known in the formulation art.

Abstract: The present invention provides a method for controlling fungal disease in plants with a fungicidal fertilizer composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. Illustrative of an invention composition is an aqueous solution which has a content of two alkali metal bicarbonate salts, an alkali metal fatty acid salt, and a water-soluble thickener such as xanthan gum. The combination of fatty acid salt and thickener functions as an effective spreader-sticker medium.

Abstract: The present invention provides a fungicide composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, xanthan gum, dialkylsulfosuccinate salt and alkyl sulfate salt surfactants, and magnesium silicate anti-caking ingredient. The xanthan gum and surfactants function as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications.

Abstract: This invention describes pharmaceutical compositions and methods of treating ulcerating diseases of the gastrointestinal tract in mammals with an acid-resistant fibroblast growth factor compositions. Also described is the use of acid-resistant fibroblast growth factor compositions in the treatment of various other fibroblast growth factor-responsive conditions.

Abstract: A pharmaceutical composition of a free amine benzophenanthridine alkaloid and a pharmaceutically acceptable carrier is disclosed. The composition is an antibacterial and antifungal agent.

Abstract: Sulfoalkyl ether cyclodextrin derivatives and their use as solubilizing agents for water insoluble drugs for oral, intranasal, or parenteral administration are disclosed.

Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a suspension stabilizing effective amount of xanthan gum, pregelatinized starch and polyoxyethylene sorbitan monooleate; an effective amount of taste masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.

Abstract: A gastric preparation developed in order to solve the technical problems of conventional preparations, which is prepared by the bilayer packing technique and comprises 5 to 60%, desirably 10 to 40% of a rapid release portion which can establish the therapeutic level of a drug shortly after the administration and 95 to 40%, desirably 90 to 60% of a sustained release portion which has a specific gravity or 1 or less and can maintain a satisfactory release rate.

Abstract: The invention is an improved ear plug composition wherein the improvement comprises the use of cotton fibers as an additional ingredient in a natural ear plug composition comprising: wax, a starch based acid ester of dicarboxylic acid, lanolin, grapefruit seed extract as well as other vitamins, etc. The use of cotton fibers in an earplug composition adds strength to the composition and tends to maintain the ear plug in one homogeneous mass.

Abstract: A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain:0.01-1 parts by weight of a binding agent0.03-0.4 parts by weight of a disintegrant0.01-0.2 parts by weight of a lubricant and0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.

Abstract: This invention discloses a liquid body powder which is applied as a lotion or a cream and which then evaporates to a powder. By applying it as a lotion or cream, the cracks and pores of the skin are filled. By virtue of the volatility of the cyclic silicone fluid containing delivery vehicle and its evaporation, a powder results which leaves no greasy residue on the skin. The liquid powder according to the present invention comprises a purified starch powder mixed with a volatile cyclomethicone silicone fluid, preferably in equal amounts by weight.

Abstract: The invention provides a solid pharmaceutical composition for addition to water to produce a suspension of a drug comprising (a) a drug which is substantially water-insoluble or microencapsulated; (b) a thickening or suspending agent; (c) a pharmaceutically acceptable acid; (d) a pharmaceutically acceptable carbonate or bicarbonate; characterised in that the weight ratio of c+d:b is from 1:1.5 to 1:15 and the amount of c+d is sufficient to obtain rapid hydration of the thickening or suspending agent (b) when the composition is mixed with water such that a homogeneous suspension of the drug is obtained within 30 seconds. A method for preparing the composition is also described.

Abstract: The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.

Abstract: This invention relates to methods for delipidation of skin or hair through the use of cyclodextrins and cyclodextrin derivatives such as hydroxypropyl .beta.-cyclodextrin. The invention also relates to cerumen removal methods involving introduction of cyclodextrins to the ear canal, followed by complexation of the cyclodextrin with cerumen components, and removal of the resulting cyclodextrin complexes. The cyclodextrin components are used in a substantially oil-free powdered or aqueous formulation without detergents, soaps, solvents, oils or other lipid-like agents.

Abstract: The use of a starch obtained from a plant source that is homozygous in a white recessive gene, such as white common corn starch, has superior compression and ejection forces compared to commercial disintegrantants/binders. The starch derived from common corn containing the homozygous white recessive gene was also found to have comparable whiteness to commercial bleached corn starches used in tableting.

Abstract: Chewable tablets containing unpleasant tasting medicaments such as cimetidine are provided. The palatability of the tablets is improved by including certain hygroscopic water-insoluble substances as extragranular excipients in amounts corresponding to 5% (w/w) to 15% (w/w) of the table.

Abstract: A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain:0.01-1 parts by weight of a binding agent0.03-0.4 parts by weight of a disintegrant0.01-0.2 parts by weight of a lubricant and0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.

Abstract: A dextrin derivative, in which a proportion of the hydroxyl groups in the dextrin have been replaced by strongly acidic groups, is useful in treatment of poisoning or drug overdose, particularly by compounds having basic groups. Dextrin sulphate is a preferred derivative for use in the treatment of paraquat poisoning.

Abstract: A method of producing an absorbent composition. A polymeric material characterized as having surface anionic reactive sites is mixed with a source of multivalent metal ions to render the polymeric material sorbent of aqueous liquids. A dispersant is then added to form a wet slurry which is subsequently dried to a granular consistency.

Abstract: A free flowing powder is prepared containing a water-soluble vitamin E compound and at least one fatty acid ester of glycerine. The powder is prepared by blending a low viscosity mixture of the vitamin E compound and fatty acid ester followed by spraying.

Abstract: A method for retaining ophthalmological agents in ocular tissues is provided comprising complexing an ophthalmological drug or reagent with a sulfated glucan sulfate such as cyclodextrin sulfate and contacting the complex so formed with the ocular tissue.

Abstract: Aqueous formulations comprising [1R-[1.alpha.(Z),2.beta.,3.beta.,5.alpha.]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl) cyclopentyl]-4-heptenoic acid or its hydrochloride salt and an unsubstituted or substituted .alpha.-, .beta.- or .gamma.-cyclodextrin have been found which are particularly useful in the treatment or prophylaxis of conditions mediated by thromboxane A.sub.2. Suitable aqueous formulations include injections, oral preparations such as syrups and capsules and inhalation preparations.

Abstract: A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccharides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.

Abstract: The invention is a composition especially for ear plugs comprised of a starch based ester of a dicarboxylic acid, lecithin, wax, trace amounts of vitamins A, C, and E and a biocidal amount of grapefruit seed extract. The ear plug composition is especially useful as it retains its elasticity after prolonged use and after being subjected to temperature extremes. The composition is safe, and also kills germs due to biocidal action of grapefruit seed extract among other ingredients.

Abstract: An abrasive free hydrogen peroxide tooth whitening dentifrice composition comprises a blend of corn starch, sorbitol, hydrogen peroxide, carbomer 940, flavor, sodium lauryl sulfate, sodium saccharin, potassium sorbate, and sodium benzoate in an aqueous base.

Abstract: A complex of a fumagillin derivative represented by the general formula: ##STR1## wherein R.sup.1 is hydrogen; R.sup.2 is halogen, N(O)mR.sup.5 R.sup.6, N.sup.+ R.sup.5 R.sup.6 R.sup.7.X.sup.-, S(O)nR.sup.5 or S.sup.+ R.sup.5 R.sup.6.X.sup.- (wherein R.sup.5, R.sup.6 and R.sup.7 are independently an optionally substituted hydrocarbon or heterocyclic group; X.sup.- is a counter anion; m is an integer of 0 or 1; n is an integer from 0 to 2; and R.sup.5 and R.sup.6 together with the adjacent nitrogen or sulfur atom may form a nitrogen- or sulfur-containing heterocyclic group which may be substituted and form a condensed ring); or R.sup.1 and R.sup.2 together represent a bond; R.sup.3 is 2-methyl-1-propenyl group or isobutyl group; A is O or NR.sup.8 (wherein R.sup.8 is hydrogen or an optionally substituted lower alkyl or aryl group); R.sup.

Abstract: Cosmetic or pharmaceutical composition consisting of a dispersion in a physiologically acceptable aqueous phase D of vesicles of ionic and/or nonionic amphiphilic lipid(s), the vesicles being bounded by one or more lipid lamellae, the lipid lamellae containing at least one retinoid compound and the aqueous dispersion phase a pyrimidine derivative. The said composition may be used by topical application on the hair and scalp.

Abstract: A method of preparing a freeze-dried dosage form including a water soluble active agent is disclosed. The water soluble active agent is bonded to an ion exchange resin to form a substantially water insoluble complex. This complex is then mixed with a compatible carrier and freeze-dried. The resulting freeze-dried dosage form contains an effective unit dosage amount of the active agent and exhibits enhanced compositional and physical stability, as well as permitting processing according to conventional freeze-drying techniques.

Abstract: Geese and swans are repelled by applying methyl anthranalate or dimethyl anthranalate to their habitats or to pelleted agricultural chemicals lethal to geese or swans. With regard to applying the repellent to habitats, preferably the repellent is encapsulated in a starch-based material that is water tolerant and provides time release of the repellent.

Abstract: This invention describes pharmaceutical compositions and methods of treating ulcerating diseases of the gastrointestinal tract in mammals with an acid-resistant fibroblast growth factor compositions. Also described is the use of acid-resistant fibroblast growth factor compositions in the treatment of various other fibroblast growth factor-responsive conditions.

Abstract: A process for preparing complexes of piroxicam with cyclodextrins in which the two components in the powder state are premixed and then co-ground in a high energy mill in the presence of steam.The products obtained have technological, physical and biopharmacological characteristics which are advantageous compared with those of liquid-state complexes obtained by traditional methods, and are suitable for preparing pharmaceutical compositions for oral, rectal and topical use.

Abstract: Fatty acid esters of polyglycerols, such as stearic acid penta(tetra)glyceryl ester, behenic acid hexa(tetra)glyceryl ester, lauric acid mono(deca)glyceryl ester, oleic acid di(tri)glyceryl ester, linolic acid di(hepta)glyceryl ester, palmitic acid deca(deca)glyceryl ester, etc. are employed as coating agents for coating solid preparations such as tablets, pills, granules, fine granules, etc. By coating with the coating agents, stable sustained release of active ingredients contained in the preparations is obtained, even after a long period of storage.

Abstract: A novel anti-sunburn skin-care preparation, such as creams, foundations, milky lotions and the like, is proposed which contains, as the ultraviolet-absorbing and -shielding ingredient, a salt of ellagic acid with a polyvalent metal, e.g., calcium, barium and magnesium. The skin-care preparation is free from the problem of irritation and sensitization of human skin and exhibits excellent anti-sunburn effect with durability.

Abstract: Undesired organisms, including insects, mites and fungi, may be combated by application of a composition which comprises a carbohydrate, protein or glycoprotein, or a functionalized derivative of any of these, as an active ingredient. Examples of materials which have been found to have relevant activity are sucrose, hydroxypropyl methylcellulose, starch and dextrinised starch. Examples of undesired organisms which have been found to be affected are whiteflies, thrips, red spider mites, cucumber powdery mildew and oat powdery mildew.

Abstract: A face masque composition useful for treating human skin for improvement comprising about 1-70% of a hydrolzed grain endproduct, about, 0.1-15% of a seaweed derivative and about 20-95% water.

Abstract: A drug preparation applicable to the oral mucosa is disclosed, comprising a soft adhesive film containing a systemic drug, the adhesive film comprising a homogeneous mixture comprising a vinyl acetate homopolymer, an acrylic acid polymer, and a cellulose derivative capable of being dissolved in or swollen with water and a lower alcohol. The drug preparation is less causative of an adverse feeling in the oral cavity on use, excellent in shape retention on water absorption, and adhesive to the oral mucosa for an extended period of time, thereby achieving a stable administration of a systemic drug for a long time.

Abstract: Sulfoalkyl ether cyclodextrin derivatives and their use as solubilizing agents for water insoluble drugs for oral, intranasal, or parenteral administration are disclosed.

Abstract: This invention relates to an analgesic composition and more particularly, to a directly dry compressible composition comprising at least about 70% by dry weight of the composition of acetaminophen and a metal carboxymethyl starch present in an amount sufficient for it to function both as a binder and as a disintegrating agent.

Abstract: A pharmaceutical composition comprising a drug and a dehydrated cyclodextrin having improved dissolution properties, and the process for the preparation thereof.

Abstract: A method for treating diarrhea in children. The method boils in water a natural source of complex carbohydrates and processes the resulting aqueous solution of complex carbohydrates to produce an aqueous solution of dextrorotatory polysaccharides having a desired osmolarity and electrolyte concentration.

Abstract: Shaving composition for the skin based on polyorganosiloxanes containing a hydroxyalkyl group and process for use. The present invention relates to a composition intended for shaving of the skin, containing, in a cosmetically acceptable medium containing a foaming agent, a polyorganosiloxane containing a hydroxyl group, of formula I: ##STR1## in which the radicals R, which may be identical or different, denote methyl or phenyl, at least 60 mol % of the radicals R being methyl; the radical R' is a divalent linear or branched C.sub.2 -C.sub.8 alkylene group of the hydrocarbon type; p is an integer between 1 and 30 inclusive; q is an integer between 1 and 150 inclusive; and also to a process for using it.

Abstract: A bait composition in a tablet form, which comprises as the essential components (a) at least one insect-growth controlling agent chosen from (a-1) insect juvenile hormone-like compounds and (a-2) insect chitin-synthesis inhibitors, (b) dextrin and (c) a plant oil in an amount of not more than 10% by weight to the total bait composition.

Abstract: Methods and materials are provided for coating hydrogel capsules containing botanic tissue with an inert substance that decrease capsule surface adhesiveness and facilitates singulation and flowability of the hydrogel capsules. The coating may be composed of at least one hydrophobic powder capable of forming a discontinuous film about the capsule surface.

Abstract: Compositions and methods for treating bacterial infections are disclosed. Compositions of a quinolone carboxylic acid or a pharmaceutically acceptable salt or metal ion-acid complex thereof and a polymeric additive that reduces vein irritation upon infusion are described and utilized as antibacterial agents. The compositions of the present invention are parenterally administered to a patient.

Abstract: There is described a new inclusion complex of nicardipine or its hydrochloride with beta-cyclohdextrin, which is prepared by admixing nicardipine or its hydrochloride with beta-cyclodextrin in a molar ratio of the compounds 1:0.9-1.1 under stirring at a temperature from about room temperature to the boiling temperature of the reaction mixture in an aqueous or ethanolic medium, cooling the reaction mixture to 0.degree. to 5.degree. C. and isolating the desired complex.The inclusion complex of nicardipine or its hydrochloride posesses cerebrovascular-vasodilatory and coronary-vasodilatory properties, which are equally well expressed as those of nicardipine or its hydrochloride themselves, yet owing to the better solubility of the complex at a higher pH range, such as it exists e.g. in the intestinal tract, the manufacture of sustained release pharmaceutical forms is made possible, whereby a greater extent of dissolution of the active substance is provided also in the intestinal juice.

Abstract: A pharmaceutical composition comprising a crystalline sugar alcohol derived from at least one mono- or polysaccharide having uniformly dispersed within its crystal matrix particles of at least one pharmaceutically active compound is disclosed. Also disclosed is a method of producing such a uniformly dispersed pharmaceutical composition by the controlled crystallization of the molten sugar alcohol having the pharmaceutically active material dispersed therein.

Abstract: A combined process is described in which inclusion complexes are formed from guest molecules and cyclodextrins during agglomeration of the cyclodextrins. Sufficient agitation in the presence of a small amount of water results in complex formation and bonding into strong agglomerates. The agglomerates are strong and stable and useful inter alia in foods (the guest molecules are flavors), pharmaceuticals (the guest molecules are drugs) and agriculture (the guest molecules are various agrochemicals).

Abstract: Cyclodextrins can be coupled to biorecognition molecules such as antibodies. The cyclodextrins so coupled provide a cavity or complexation zone into which active agents such as labels, drugs and the like may be incorporated. The active agent forms a noncovalently bonded inclusion complex within the cavity of the cyclodextrin. It remains associated with the cyclodextrin and the coupled biorecognition molecule and thus can be delivered to the other half of the biospecific recognition pair. A process for producing these materials is also disclosed. The process includes the steps of activating a primary hydroxyl site on a cyclodextrin; linking a biorecognition molecule to the activated primary hydroxyl site on the cyclodextrin in either a direct covalent linkage or through a covalently linked spacer; and introducing a guest molecule (active agent) into the cavity of the derivatized cyclodextrin to form an inclusion complex.

Abstract: Sprayable, starch-based formulations for autoencapsulating biological control agents, such as pathogenic bacteria and viruses, incorporate a sugary material to promote adherence of the encapsulated agent to treated foliage. The autoencapsulated pathogens are characterized by high survivability and are useful in controlling insects and other pest species.

Abstract: Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of H, (except that R.sub.1 and R.sub.2 are not both H), Cl, Br, I, NO.sub.2, NH.sub.2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO.sub.3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.