Starch Or Derivative Patents (Class 514/778)
-
Patent number: 5028633Abstract: A process for preparing a compression molding excipient comprises dispersing cellulose powder and hydroxypropyl starch powder in water or aqueous solutions of starch or hydroxypropyl starch and spray drying the dispersion. The excipients are useful for tablet moldings having optimum hardness and disintegration properties.Type: GrantFiled: February 21, 1985Date of Patent: July 2, 1991Assignee: Freund Industrial Co., Ltd.Inventors: Shigeru Ohno, Masayuki Ikeda
-
Patent number: 5026772Abstract: A lyophilized pharmaceutical composition comprised of a neocarzinostatin derivative having the formula (SMA)-(NCS)-(SMA), is made by a method including dissolving the neocarzinostatin derivative and stabilizing agent comprising at least one saccharide selected from the group consisting of monosaccharides, disaccharides and dextran in an aqueous buffer solution having a pH ranging from about 7.5 to about 9.5, the stabilizing agent being present in an amount by weight (titer) which is at least equal to that of the neocarzinostatin derivative, to provide a solution; adjusting the pH of the solution to provide a pH-adjusted solution having a pH of about 8.0.+-.0.5; sterilizing the pH-adjusted solution by filtration to provide a sterilized solution; and lyophilizing the sterilized solution.Type: GrantFiled: August 29, 1988Date of Patent: June 25, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Mitsugu Kobayashi, Go Ohtani, Jun Sekino, Toshimitsu Konno, Hiroshi Maeda
-
Patent number: 5009882Abstract: The present invention relates to compositions and methods for inhibiting plaque. In particular, this invention relates to oral compositions comprising: (a) a safe and effective amount of a plaque-inhibiting carboxy starch polymer comprising the formula ##STR1## wherein W and X are independently selected from CH.sub.2 OH, CHO and CO.sub.2 H, or the neutralized carboxylic acid salts thereof, Y and Z are independently selected from CHO and CO.sub.2 H, or the neutralized carboxylic acid salts thereof, n is in the range of from about 5 to about 2500, m is in the range of from 0 to about 2500, provided that the sum of n and m ranges from about 5 to about 2500, and the degree of carboxylation of said active agent ranges from about 1 to about 3; and (b) a pharmaceutically acceptable carrier. These compositions inhibit plaque without staining the teeth which are contacted with the composition.This invention also relates to a method of inhibiting plaque on tooth surfaces in the oral cavity.Type: GrantFiled: May 21, 1990Date of Patent: April 23, 1991Assignee: The Proctor & Gamble CompanyInventors: Charles R. Degenhardt, Barbara A. Kozikowski
-
Patent number: 5002935Abstract: Inclusion complexes of hydroxypropyl-.beta.-cyclodextrin with the reduced biooxidizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine.revreaction.pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The reodox inclusion complexes also provide a means for decreasing initial drug concentrations in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.Type: GrantFiled: December 30, 1987Date of Patent: March 26, 1991Assignee: University of FloridaInventor: Nicholas S. Bodor
-
Patent number: 4929577Abstract: A transparent gel composition is provided for dressing of skin wounds. The dressing is in the form of a sheet comprising dextrin and a water-swellable, cross-linked polymer selected from polyacrylamide or polymethacrylamide. The ratio of dextrin to polymer ranges from about 2:1 to 1:1.Type: GrantFiled: March 11, 1987Date of Patent: May 29, 1990Assignee: Medi-Tech International CorporationInventor: John Cornell
-
Patent number: 4894224Abstract: The organopolysiloxane composition of the invention is a highly viscous liquid or paste suitable as a base of pasty cosmetic and medicinal preparations such as creams, hair-dressings, ointments and the like. The composition comprises an oligomeric cyclic organopolysiloxane compound, an oleaginous material and a cellulose ether esterified with long-chain alkanoyl groups as the thickening agent. The cosmetic and medicinal preparations prepared from the inventive composition as the base have good spreadability on the human skin and are capable of giving very refreshing feeling to the user or patient without lasting stickiness.Type: GrantFiled: April 20, 1988Date of Patent: January 16, 1990Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Satoshi Kuwata, Ikuo Fukui
-
Patent number: 4892889Abstract: A process for making a directly-compressible vitamin powder utilizes a conventional spray-dryer. The resulting powder is comprised of a fat-soluble vitamin, a water-soluble carbohydrate, and a gelatin having a bloom number between 30 and 300.Type: GrantFiled: October 2, 1987Date of Patent: January 9, 1990Assignee: BASF CorporationInventors: Paula S. Kirk, Dale R. Olson
-
Patent number: 4863731Abstract: Aqueous concentrates intended for addition to nutrient material in the manufacture of feedstuffs for poultry are provided consisting essentially of water and from about 1000 to about 1,000,000 viable sporulated oocysts of at least one species of coccidia to which poultry are susceptible and at least one edible thickening agent which facilitates the mixing of the oocysts into feedstuff without destructive frictional heat.Type: GrantFiled: May 20, 1987Date of Patent: September 5, 1989Assignee: Unilever Patent Holdings B.V.Inventors: Paul J. Davis, James F. Reynolds
-
Patent number: 4857307Abstract: Liquid makeup compositions containing an oil-absorbing effective amount of distarch phosphate in an alcohol-free e.g. ethanol-free-liquid makeup formulation which may be anhydrous, an oil-in-water emulsion or a water-in-oil emulsion.Type: GrantFiled: November 17, 1987Date of Patent: August 15, 1989Assignee: Plough, Inc.Inventors: Harold Suss, Virginia F. Ner
-
Patent number: 4843098Abstract: The present invention relates to an ingestible aggregate comprising a pre-swelled substantially anhydrous hydrocolloid and a substrate. More particularly this invention relates to an aggregate having as a substrate a dietary fiber and/or drug wherein the composition can be administered in a therapeutically effective amount. Hydrocolloids useful include natural and modified gums, celluloses, modified celluloses, pectins, mucillages, modified starches, noncellulose polysaccharides, algal polysaccharides and mixtures thereof. The aggregate should be in the size range of about 4 to about 70 U.S. mesh. The unpleasant taste and mouthfeel of the fiber and/or drug is effectively masked and substantial hydration is delayed until the composition reaches the stomach. The compositions are substantially more palatable, devoid of graininess, bitterness or fibrous texture. The pleasant taste of the composition encourages patient compliance with their fiber or drug therapy.Type: GrantFiled: February 29, 1988Date of Patent: June 27, 1989Assignee: Warner-Lambert CompanyInventors: James J. Shaw, Shri C. Sharma
-
Patent number: 4812445Abstract: Virtually any material may be encapsulated in a starch matrix by combining the material with a high temperature-stabilized dispersion of starch, optionally in the presence of salt. The temperature-stabilized starch dispersion acts as a protective colloid, encasing the material to be encapsulated. Upon subsequent rapid cooling of this mixture on a chilled surface the starch polymer chains collapse upon themselves, forming a firm sheet or the like and encapsulating the core material. The sheet can then be cut, chopped or sliced in the wet state, then dried and ground to yield particles.Type: GrantFiled: April 23, 1987Date of Patent: March 14, 1989Assignee: National Starch and Chemical CorporationInventors: James Eden, Ralph Trksak, Robert Williams
-
Patent number: 4800095Abstract: L-aspartic acid sweetening agent derivatives are stabilized in comestibles containing .gtoreq.2% moisture by being formulated with cooked aqueous hydrogenated starch hydrolysate having a moisture content of 10.+-.6%. Optionally, glycerine may also be used.Type: GrantFiled: March 3, 1988Date of Patent: January 24, 1989Assignee: Nabisco Brands, Inc.Inventors: Thomas J. Carroll, Gary S. Kehoe
-
Patent number: 4755386Abstract: A buccal formulation for administering a medicament includes about 1-20% by weight of a soluble, pharmaceutically acceptable adhesive, about 1-10% by weight of a pharmaceutically acceptable disintegrant and a soluble, directly compressible tablet excipient.Type: GrantFiled: January 22, 1986Date of Patent: July 5, 1988Assignee: Schering CorporationInventors: Chiin H. Hsiao, Janice L. Cacace
-
Patent number: 4747881Abstract: The present invention relates to an ingestible aggregate comprising a pre-swelled substantially anhydrous hydrocolloid and a substrate. More particularly this invention relates to an aggregate having as a substrate a dietary fiber and/or drug wherein the composition can be administered in a therapeutically effective amount. Hydrocolloids useful include natural and modified gums, celluloses, modified celluloses, pectins, mucillages, modified starches, noncellulose polysaccharides, algal polysaccharides and mixtures thereof. The aggregate should be in the size range of about 4 to about 70 U.S. mesh. The unpleasant taste and mouthfeel of the fiber and/or drug is effectively masked and substantial hydration is delayed until the compositions reaches the stomach. The compositions are substantially more palatable, devoid of grainless, bitterness or fibrous texture. The pleasant taste of the composition encourages patient compliance with their fiber or drug therapy.Type: GrantFiled: February 5, 1985Date of Patent: May 31, 1988Assignee: Warner-Lambert CompanyInventors: James J. Shaw, Shri C. Sharma
-
Patent number: 4746510Abstract: A cosmetic composition for the treatment of the hair and skin comprising, in an aqueous medium, particles of pulverized flowers or flower tops having a granulometry lower than 125 microns and a cohesion agent present in an amount effective to maintain the homogeneity of the composition. The cohesion agent can be a thickening agent, a water-in-oil emulsion or an oil-in-water emulsion.Type: GrantFiled: February 24, 1986Date of Patent: May 24, 1988Assignee: L'OrealInventors: Jean-Francois Grollier, Josiane Allec, Chantal Fourcadier, Georges Rosenbaum, Patrick Darmenton
-
Patent number: 4681765Abstract: A gelatin capsule dosage form containing triamterene, 2,4,7-triamino-6-phenylpteridine, which results in rapid dissolution of the active ingredient. The dosage form comprises the pharmaceutical binder methylcellulose in combination with low doses of a surfactant or a carbonate salt as disintegrants.Type: GrantFiled: September 13, 1984Date of Patent: July 21, 1987Assignee: American Home Products CorporationInventor: Paul C. Guley
-
Patent number: 4675188Abstract: A granular directly compressible anhydrous dicalcium phosphate having a particle size sufficient for efficient direct compression tableting, preferably at least 90 percent greater than 44 microns, a dentin abrasion value of less than 150 and a surface area of greater than 5 meters.sup.2 /gram can be prepared by dehydrating particles of soft dicalcium phosphate dihydrate of a particle size insufficient for direct compression tableting, preferably at least 10 percent less than about 44 microns such as by heating at a temperature sufficient to form anhydrous dicalcium phosphate. The dehydrated particles are then granulated with a binder. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility and flowability while being in an anhydrous state.Type: GrantFiled: August 2, 1985Date of Patent: June 23, 1987Assignee: Stauffer Chemical CompanyInventor: Chihang R. Chu
-
Patent number: 4665100Abstract: A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.Type: GrantFiled: February 15, 1983Date of Patent: May 12, 1987Assignee: Eli Lilly and CompanyInventor: Nelson H. Ludwig
-
Patent number: 4663316Abstract: Cyclodextrin clathrates of certain unsaturated phosphorous containing antibiotics exhibit enhanced stability in pharmaceutical compositions.Type: GrantFiled: June 28, 1985Date of Patent: May 5, 1987Assignee: Warner-Lambert CompanyInventors: Fred C. Ninger, Weichi Liao
-
Patent number: 4663308Abstract: Polymers from ethylenically unsaturated monomers, cross-linked by a substituted or unsubstituted divinylazobenzene are useful as carriers or capsules for medicaments, which are degraded by the enzymes of the upper gastrointestinal tract or which must be transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine.Polymers containing monomeric units of the formulaH.sub.2 C.dbd.CH--C.sub.6 H.sub.4 --N.dbd.N--M,wherein M is the residue of an amino-containing medicament, are useful as carriers for therapeutic agents or as therapeutic agents per se.Type: GrantFiled: July 18, 1984Date of Patent: May 5, 1987Assignees: Medical College of Ohio, Bowling Green State UniversityInventors: Murray Saffran, Douglas C. Neckers
-
Patent number: 4643894Abstract: A pharmaceutical, confectionery or food tablet coated on all its exterior surfaces with maltodextrin, which masks the characteristic taste of the tablet ingredients and does not have a slimy taste, with the coating composition comprising maltodextrin, an effective amount of a plasticizer to make the maltodextrin non-brittle and non-cracking when coated onto a tablet, an effective amount of a detackifier for making the maltodextrin and plasticizer non-tacky, a secondary film former to impart gloss and strength to the maltodextrin film coating, and a colorant for imparting color. A method of making tablets coated with maltodextrin.Type: GrantFiled: July 24, 1984Date of Patent: February 17, 1987Assignee: Colorcon, Inc.Inventors: Stuart C. Porter, Edward J. Woznicki
-
Patent number: 4601895Abstract: A delayed-action acetylsalicylic acid formulation comprising by weight 60 to 90% of acetylsalicylic acid, 8 to 40% pregelatinized starch, and 0 to 30% of additives. The amount of starch controls the rate of release.Type: GrantFiled: December 6, 1984Date of Patent: July 22, 1986Assignee: Bayer AktiengesellschaftInventors: Bernhard Streuff, Johann Putter, deceased
-
Patent number: 4593048Abstract: A composition capable of promoting the skin permeation or percutaneous absorption of a drug, which comprises a lower alcohol and at least one member of the group consisting of a saturated aliphatic hydrocarbon containing 5 to 20 carbon atoms, which may optionally be halogen-substituted, a monohydric alcohol ester of an aliphatic carboxylic acid, which contains 13 to 24 carbon atoms, and an ether containing 8 to 16 carbon atoms with one ether bondage in the molecule; and an external preparation containing the above composition as a base.Type: GrantFiled: May 13, 1983Date of Patent: June 3, 1986Assignee: Nitto Electric Industrial Co., Ltd.Inventors: Susumu Sato, Umiko Takakura, Mitsuru Tamada
-
Patent number: 4581230Abstract: A cosmetic composition for the treatment of the hair and skin comprising, in an aqueous medium, particles of pulverized flowers or flower tops having a granulometry lower than 125 microns and a cohesion agent present in an amount effective to maintain the homogeneity of the composition. The cohesion agent can be a thickening agent, a water-in-oil emulsion or an oil-in-water emulsion.Type: GrantFiled: April 25, 1984Date of Patent: April 8, 1986Assignee: L'OrealInventors: Jean-Francois Grollier, Josiane Allec, Chantal Fourcadier, Georges Rosenbaum, Patrick Darmenton
-
Patent number: 4568539Abstract: Body powder compositions exhibiting excellent moisture absorbency comprising starch and a specific pregelatinized cornstarch.Type: GrantFiled: August 3, 1983Date of Patent: February 4, 1986Assignee: Johnson & Johnson Baby Products CompanyInventors: William H. Ashton, Robert S. Russell, David C. Zajac
-
Patent number: 4568541Abstract: The invention relates to insecticidal formulations which have a pronounced residual action and contain (a) 0.1 to 20% by weight of an insecticidally active compound or compounds, (b) 1 to 40% by weight of a water-soluble gel-forming or lacquer-forming polymer, (c) 40 to 98% by weight of organic, water-miscible solvent, and (d) 0.1 to 10% by weight of one or more further additives.Type: GrantFiled: January 13, 1983Date of Patent: February 4, 1986Assignee: Bayer AktiengesellschaftInventors: Hubert Dorn, Wilhelm Stendel, Herbert Voege
-
Patent number: 4529587Abstract: A cosmetically acceptable composition for topical application to human skin or hair in order to reduce greasiness comprises, at a concentration of from 0.0001M to 0.5M, a biotin antagonist which is capable of blocking the activity of the biotin dependent enzyme acetyl-SCoA-carboxylase implicated in sebum production; together with a carrier other than water as an aid to delivering the biotin antagonist to the sebaceous gland.Type: GrantFiled: February 1, 1983Date of Patent: July 16, 1985Assignee: Lever Brothers CompanyInventor: Martin R. Green
-
Patent number: 4524064Abstract: Provided is a wound covering material produced by applying an aqueous solution containing a polyvinyl alcohol with a degree of hydrolysis not less than 95 mol. % and a viscosity-average degree of polymerization not less than 1,500, a water-soluble C.sub.2-20 polyhydric alcohol having 2-8 hydroxyl groups in the molecule and a high-viscosity water-soluble macromolecular substance being different from polyvinyl alcohol with a viscosity of the 2% aqueous solution of 25.degree. C. not less than 300 cP, concentrations of said polyvinyl alcohol, said water-soluble polyhydric alcohol and said water-soluble macromolecular substance being adjusted respectively to 1.5-8% by weight, 10-85% by weight and 0.2-15% by weight, onto a flat or curved plate having 30,000-200,000 projections per m.sup.2, the total area occupied by the projections being 10-70% to a thickness from 0.5 to 5 mm, cooling the applied plate to a temperature not higher than -6.degree. C.Type: GrantFiled: May 24, 1983Date of Patent: June 18, 1985Assignee: Nippon Oil Company, LimitedInventor: Masao Nambu