Starch Or Derivative Patents (Class 514/778)
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Patent number: 5688521Abstract: Object of the invention is a single dose form of application for lactulose in the form of pastilles based on at least partially or completely water soluble natural and/or synthetic polymers selected from gums, alginates, carrageen, starch, pectin, and gelatin comprising lactulose as active substance, as well as a process to prepare the said pastilles.Type: GrantFiled: December 1, 1995Date of Patent: November 18, 1997Assignee: Bolder Arzneimittel GmbHInventors: Hermann-Josef Bolder, Faruk Imer
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Patent number: 5688522Abstract: Wound healing compositions comprise from 1 to 20% by weight of a gel forming polysaccharide such as carboxymethyl cellulose and from 15 to 50% by weight of hexylene glycol. Such compositions are strongly antimicrobial, but show low toxicity to fibroblasts.Type: GrantFiled: August 13, 1996Date of Patent: November 18, 1997Assignee: Johnson & Johnson Medical, Inc.Inventor: Craig J. Hardy
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Patent number: 5686385Abstract: The present invention provides microcapsule comprising agricultural active ingredients with improved physical properties, and an agricultural composition comprising said microcapsule. An agricultural microcapsule having a diameter of not more than 50 .mu.m comprises an agricultural active ingredient in a water-soluble coating material. As an agricultural composition comprising said microcapsules, DL dust, solidified emulsifiable concentrate can be provided.According to the present invention, the agricultural active ingredient is stabilized, agricultural dust can be mixed with even incompatible, liquid agricultural active ingredient, and agricultural microcapsule has excellent handling properties.Type: GrantFiled: June 5, 1995Date of Patent: November 11, 1997Assignee: Takeda Chemical Industries, Ltd.Inventors: Kanji Akashi, Chikara Tanabayashi, Kazutaka Kitagawa
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Patent number: 5684051Abstract: Elastically deformable medical devices, such as stents, having improved speed and degree of shape recovery are made by treating shaped hydrogels containing a polymer with a solution containing at least one elasticity agent, which may be nonionic or ionic. For example, polysaccharide-based hydrogels, such as barium alginate, are formed into tubing, shaped into pigtail stents, and exposed to an aqueous solution containing an elasticity agent such as potassium ions, sodium ions, sorbitol, glucose, citric acid, mannitol, dulcitol, or glycerol. The solution may also contain a crosslinking agent, such as calcium ions, to achieve the desired degree of elasticity.Type: GrantFiled: April 24, 1996Date of Patent: November 4, 1997Assignee: Hercules IncorporatedInventor: Samuel Anthony Thompson
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Patent number: 5672356Abstract: Bioadhesive pharmaceutical composition for the controlled release of active principles locally across the buccal cavity or systemically across a mucous membrane, wherein it is composed of an active principle, a compound (A), a compound (B) and excipients as defined in the description.Type: GrantFiled: September 21, 1994Date of Patent: September 30, 1997Assignee: Adir et CompagnieInventors: Isabelle Rault, Gerald Pichon, Alain Cuine
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Patent number: 5670158Abstract: The subject invention involves pharmaceutical compositions in dosage unit form, for peroral administration of bisacodyl to a human or lower animal having a gastrointestinal tract, with a lumen therethrough, with a small intestine and a colon with a junction therebetween, comprising:(a) a safe and effective amount of rapidly-dissolving bisacodyl means; and(b) a delivery means which prevents the release of bisacodyl from the dosage form into the lumen of the gastrointestinal tract during transport of the dosage form through the lumen until the dosage form is near the junction between the small intestine and the colon or in the colon, and which then releases the bisacodyl in the lumen near the junction between the small intestine and the colon or within the colon,The subject invention also involves methods for providing laxation for humans and lower animals in need thereof by peroral administration of such compositions.Type: GrantFiled: November 15, 1995Date of Patent: September 23, 1997Assignee: The Procter & Gamble CompanyInventors: Paula Denise Davis, Douglas Joseph Dobrozsi, Gary Robert Kelm, Kenneth Gary Mandel
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Patent number: 5667803Abstract: The present invention is related to a novel type of composition with modifiable properties and suitable for controlled release of active ingredients in industrial use. The composition contains an active ingredient and starch acetate in the form of a compact. More specifically the invention relates to active ingredients such as solid dosage forms of drugs, especially compacts and tablets. In these compacts starch acetate with distinct substitution degrees are used. The starch acetate makes the process industrially feasible with good flowability and facilitates the formation of firm tablets. Starch acetate enables the controlled release of the active ingredient. The invention also discloses method for the preparation of the composition as well as its use.Type: GrantFiled: January 19, 1995Date of Patent: September 16, 1997Assignee: Oy Polymer Corex Kuopio Ltd.Inventors: Timo Petteri Paronen, Soili Hellevi Peltonen, Arto Olavi Urtti, Leena Johanna Nakari
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Patent number: 5667801Abstract: A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.Type: GrantFiled: May 21, 1996Date of Patent: September 16, 1997Assignee: Edward Mendell Co., Inc.Inventor: Anand R. Baichwal
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Patent number: 5662933Abstract: A sustained release pharmaceutical formulation and methods of making and using the same are provided. The sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional hydrophobic material and/or hydrophobic coating, and a medicament for sustained oral administration.Type: GrantFiled: November 3, 1995Date of Patent: September 2, 1997Assignee: Edward Mendell Co., Inc.Inventors: Anand Baichwal, Troy W. McCall
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Patent number: 5662937Abstract: A long life deodorant composition lasting up to about 7 days for foot odor, and up to about 15 days underarm, includes specially treated cornstarch or oat starch as a substitute for talc. Additionally the treated starch acts as a spreading agent, giving a silky smooth effect. Citric acid, an increased proportion of zinc oxide and aloe vera concentrate are advantageously included in the deodorant.Type: GrantFiled: August 17, 1995Date of Patent: September 2, 1997Inventor: Dorothy McCuaig
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Patent number: 5658895Abstract: The invention provides an anticancer enteral feeding composition characterized by containing the described assortment of amino acids, fat and carbohydrate.This anticancer enteral feeding composition can be smoothly administered orally or via a tube to achieve alimentation of cancer patients and inhibition of growth of tumor cells in the patients. Moreover, as used in combination with an anticancer chemotherapeutic agent, it synergistically potentiates the antitumor efficacy of the latter agent.Type: GrantFiled: June 6, 1995Date of Patent: August 19, 1997Assignee: Otsuka Pharmaceutical Factory, Inc.Inventors: Shozo Aoi, Goro Ebisu
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Patent number: 5656292Abstract: The present invention is related to a composition for pH dependent or pH regulated controlled release of active ingredients especially drugs. The composition consists of a compactible mixture of the active ingredient and starch molecules substituted with acetate and dicarboxylate residues. The preferred dicarboxylate acid is succinate. The average substitution degree of the acetate residue is at least 1 and 0.2-1.2 for the dicarboxylate residue. The starch molecules can have the acetate and dicarboxylate residues attached to the same starch molecule backbone or attached to separate starch molecule backbones. The present invention also discloses methods for preparing said starch acetate dicarboxylates by transesterification or mixing of starch acetates and starch dicarboxylates respectively.Type: GrantFiled: July 5, 1995Date of Patent: August 12, 1997Assignee: Alko Group Ltd.Inventors: Arto Olavi Urtti, Soili Hellevi Peltonen, Timo Petteri Paronen, Leena Johanna Nakari, Jani-Emanuel Vuorenpaa
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Patent number: 5651983Abstract: The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising:a. a safe and effective amount of rapidly dissolving bisacodyl incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; andb. an enteric polymer coating material;wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.Type: GrantFiled: May 17, 1995Date of Patent: July 29, 1997Assignee: The Procter & Gamble CompanyInventors: Gary Robert Kelm, Gary Lee Manring, Paula Denise Davis, Douglas Joseph Dobrozsi, Kenneth Gary Mandel, David Lee McCauley-Meyers
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Patent number: 5648390Abstract: A method has been discovered for repelling ants by treating objects or areas with effective amounts of compositions that include (a) one or more C.sub.6 to C.sub.8 carboxylic acids; (b) one or more C.sub.6 to C.sub.14 alcohols; (c) one or more esters which are reaction products of (a) and (b) or an ester which is a reaction product of the repellents and other carboxylic acids or alcohols; (d) one or more C.sub.6 to C.sub.11 carboxylic acid esters; (e) one or more C.sub.6 to C.sub.14 ketones; or (f) mixtures thereof.Type: GrantFiled: August 4, 1994Date of Patent: July 15, 1997Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Robert K. Vander Meer, William A. Banks, Clifford S. Lofgren
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Patent number: 5643603Abstract: A composition of a bioadhesive carrier for a prolonged, sustained and controlled delivery of a drug having a local or systemic action contains pregelatinized or thermally modified, food accepted starches and optionally a synthetic polymer.The pregelatinized starches are preferably precooked and dried starches.Type: GrantFiled: July 13, 1994Date of Patent: July 1, 1997Assignee: Janssen Pharmaceutica N.V.Inventors: Peter Bottenberg, Jean Paul Louis August Remon, Christian Dominique Erwin De Muynck, Dick Slop
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Patent number: 5639468Abstract: Compositions and methods for minimizing or preventing post-surgical adhesion formation between tissue, e.g., organ, surfaces in body cavities, whereby an effective therapeutic amount of manoalide or analog thereof is administered to the target injury site for a period of time sufficient to permit tissue repair. Manoalide or analog thereof is preferably administered in conjunction with a delivery vehicle (e.g., microcapsules, microspheres, biodegradable polymer films, lipid-based delivery systems such as liposomes and lipid foams, crystalloid and viscous instillates and absorbable mechanical barriers) useful for maintaining local concentrations of the inhibitor at the injury site at an effective level for a sustained period of time.Type: GrantFiled: June 7, 1995Date of Patent: June 17, 1997Assignee: University of Southern CaliforniaInventors: Kathleen Elizabeth Rodgers, Gere Stodder diZerega
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Patent number: 5631013Abstract: This invention provides cosmetic stick, roll-on and cream deodorant and deodorant-antiperspirant products. The cosmetic products consisting of an organic matrix having a dispersed phase of encapsulated particles of a co-micronized crystallite blend of inorganic compounds such as sodium bicarbonate and zinc oxide. The particle surfaces are coated with a polymer such as maltodextrin starch. When this type of cosmetic product is applied to underarm surfaces, a sustained deodorant activity by the encapsulated particles is obtained.Type: GrantFiled: August 7, 1995Date of Patent: May 20, 1997Assignee: Church & Dwight Co., Inc.Inventors: Wolfgang R. Bergmann, Richard T. Murphy
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Patent number: 5629018Abstract: In a composition for delayed release of an active substance, the active substance is incorporated in a polysaccharide matrix which consists of an essentially crystalline straight-chain glucan and contains a glucan-degrading agent. The glucan is in particular an .alpha.-glucan which has essentially a helix structure. The glucan-degrading agent is preferably .alpha.-amylase. The composition can contain high-molecular materials such as proteins, allergens, vaccine substances and microorganisms, and preferably has the form of compressed tablets.Type: GrantFiled: February 15, 1995Date of Patent: May 13, 1997Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNOInventors: Arie C. Besemer, Jan P. Van Der Lugt
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Patent number: 5629350Abstract: Stable, concentrated aqueous suspensions of ortho-phenylphenol (OPP) which contribute minimal chemical oxygen demand and methods of preparing and using said suspensions in biocidal applications have been discovered. The formulations comprise from about 3 to about 70 weight percent of OPP suspended in about 30 to about 97 weight percent water in the presence of a suspending amount of a thixotrope that exhibits Ellis-Plastic behavior.Type: GrantFiled: March 20, 1996Date of Patent: May 13, 1997Assignee: The Dow Chemical CompanyInventor: Charles D. Gartner
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Patent number: 5626878Abstract: A medicament adsorbate containing corn syrup having contained therein from about 10 to about 90% by weight of the adsorbate of a medicament drug a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a structure with multiple interstitial spaces, and having adsorbed therein from about 0.5 to about 30% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antihistamine. A reduction in the electrostatic forces between adsorbates is experienced due to the particle size of the adsorbate being in the range greater than 40 to about 800 um, most of the adsorbates prepared being a particle size greater than 150 um, which allows for better processing.Type: GrantFiled: January 10, 1995Date of Patent: May 6, 1997Assignee: Warner Lambert CompanyInventors: Felipe Garay, Stanley Lech, Mark Oehling
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Patent number: 5624683Abstract: A sustained-release multi-granule tablet is obtained by compressing sustained-release granules, which contains a basis, and a formulation adjuvant. Each of the granules has been coated in advance with a layer of the formulation adjuvant and/or a layer of a mixture of the formulation adjuvant and the basis. The tablet releases an active substance at a suitable velocity into the digestion tract, resulting in that the inbalance in the absorption of the drug in each patient and among individual patients is minimized to achieve maximum bioavailability.Type: GrantFiled: February 7, 1994Date of Patent: April 29, 1997Assignee: Eisai Co., Ltd.Inventors: Hidenobu Andoh, Sumio Watanabe, Yasuo Miyake
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Patent number: 5624677Abstract: A composition providing a relatively slow release of water-soluble drugs, such as apomorphine, for delivery via the sublingual or buccal routes.Type: GrantFiled: June 13, 1995Date of Patent: April 29, 1997Assignee: Pentech Pharmaceuticals, Inc.Inventors: Ragab El-Rashidy, Bruce Ronsen, Emad E. Hassan
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Patent number: 5618850Abstract: A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.Type: GrantFiled: March 9, 1995Date of Patent: April 8, 1997Assignee: Focal, Inc.Inventors: Arthur J. Coury, Luis Z. Avila, Chandrashekhar P. Pathak, Shikha P. Barman
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Patent number: 5616324Abstract: A synergistic mixture particularly suitable for the treatment of animals whic consists of at least two of the group consisting of DL.Phenylalanine, Ruta Graveolans and Corydali Bulbosa together with a carrier to make up a required volume, the mixture having a pro-inflammatory effect which accelerates the healing process of inflammation. It is preferred that there is provided mixture of DL.Phenylalanine with one product selected from the group of Ruta Graveolans and Corydalis Bulbosa. In a specific form, the mixture also includes Nicotinic Acid.Type: GrantFiled: May 31, 1995Date of Patent: April 1, 1997Inventors: Antoinette Foster, Don Foster
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Patent number: 5614217Abstract: A gelatin capsule that is generally resistant to humidity having a non-hygroscopic plasticizer and an elasticity reducing gelatin extender in the formulation of the gelatin capsule shell. The capsule is capable of being manufactured on conventional rotary die encapsulation devices and can readily hold liquid fill materials. The capsule is breakable with manual pressure.Type: GrantFiled: June 7, 1995Date of Patent: March 25, 1997Assignee: R.P. Scherer CorporationInventors: Timothy B. Chiprich, Michael T. Hoylman, Norman S. Stroud
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Patent number: 5595762Abstract: Stabilized pulverulent active agents, compositions containing them and also process for obtaining them; such stabilized active agents enable dry and stable pharmaceutical, dietary, nutritional or cosmetic compositions to be obtained, in which the properties of the said active agents are neither modified nor impaired. Such stabilized active agents are stabilized by coating with a coating composition comprising:-- at least one film-forming agent, in proportions of between 2 and 25% by weight of the final mass, selected from polyvinylpyrrolidones (povidone), polyvinyl alcohols, vinylpyrrolidone/vinyl acetate copolymer, vinylpyrrolidone/polyvinyl alcohol copolymer, cellulose derivatives such as cellulose acetate, cellulose acetate phthalate, cellulose butyrate, ethylcellulose and methylcellulose, acrylic and methacrylic polymers and copolymers and vegetable, animal or synthetic waxes, and-- at least one pore-forming agent, in proportions of between 0 and 5%, by weight preferably of between 0.Type: GrantFiled: November 30, 1993Date of Patent: January 21, 1997Assignee: Laboratoires VirbacInventors: Guy Derrieu, Bernard Raynier
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Patent number: 5591611Abstract: Disclosed is a trehalose-releasing enzyme which specifically hydrolyzes the linkage between a trehalose moiety and the remaining glycosyl moiety in a non-reducing saccharide having a trehalose structure as an end unit and having a degree of glucose polymerization of 3 or higher. The molecular weight of the enzyme is about 57,000 to 68,000 daltons on SDS-PAGE, and the isoelectric point is about 3.3 to 4.6 on isoelectrophoresis. The enzyme is useful in an industrial-scale preparation of trehalose, and the trehalose prepared therewith can be readily incorporated into food products, as well as cosmetic- and pharmaceutical-compositions.Type: GrantFiled: June 5, 1995Date of Patent: January 7, 1997Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazuhiko Maruta, Michio Kubota, Toshiyuki Sugimoto, Toshio Miyake
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Patent number: 5565407Abstract: Improved release-extending compositions are provided for encapsulation of bioactive agents which exhibit reduced release rates of the bioactive agent from the composition matrix when compared with conventional encapsulated formulations, most preferably employed in agricultural applications for insect and weed control. The compositions of the invention from about 25-75 wt. % (non-active ingredient basis) native, undenatured starch, from about 25-75 wt. % (non-active ingredient basis) biodegradable synthetic polymer, and from about 1-40 wt. % bioactive agent.Type: GrantFiled: December 19, 1994Date of Patent: October 15, 1996Assignee: University of Kansas Center for Research, Inc.Inventor: Marylee Z. Southard
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Patent number: 5554577Abstract: The subject matter comprises shaped mixtures of valuable materials for the stimulation and cultivation of plant growth, said materials containing plant nutrients and/or plant-protective agents in admixture with a thermoplastic binder. According to the invention the mixtures of valuable materials, which mixtures have in particular been shaped as fertilizer rods, are characterized in that they contain, as the binder, a starch that has been thermomechanically digested at elevated pressures and temperatures.The invention further relates to the process for producing these multi-component mixtures and to the use of thermomechanically digested starch, optionally in admixture with inferior amounts of further biologically compatible binder components, as a biologically degradable binder for mixtures of valuable materials of the type described.Type: GrantFiled: October 13, 1994Date of Patent: September 10, 1996Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Wolfgang Kempf, Peter Schroeder, Wolfgang Ritter, Bernd Ebbe
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Patent number: 5554388Abstract: A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the pharmacologically active compound is preferably insulin or calcitonin. The composition may be a solution, dispersion, powder or microspheres. Other enhancers, such as lysophosphatidylcholine, can be included if desired.Type: GrantFiled: December 14, 1993Date of Patent: September 10, 1996Assignee: Danbiosyst UK LimitedInventor: Lisbeth Illum
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Patent number: 5540930Abstract: The invention provides novel compositions of matter containing water-insoluble steroid drugs suitable for therapeutic use. The invention provides stable aqueous suspensions of water-insoluble steroid drugs of particle sizes of .ltoreq.15 .mu.m which remain in such a state so as to allow for immediate suspension, when desired, even after extended periods of settling.Type: GrantFiled: October 25, 1993Date of Patent: July 30, 1996Assignee: Pharmos CorporationInventors: Yaacov J. Guy, Doron I. Friedman
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Patent number: 5534262Abstract: A granulated composition for direct tableting, comprising non-pressed or difficulty pressed, water-soluble, crystalline pharmaceutical substances, binder, lubricant and water, contains at least 98 wt. % of a pharmaceutically active component. The tablets manufactured from said composition have high hardness and the controllable time of dissolution. A method for preparing said composition consists in that the powder of a pharmaceutical substance is pre-granulated with water or its aqueous solution, the resultant granulate is then subjected to subsequent granulation with a binder solution, dried and powdered with lubricant.Type: GrantFiled: September 10, 1993Date of Patent: July 9, 1996Inventors: Anatoly E. Dobrotvorsky, Yaroslav A. Rozputnyak, Galina N. Khuchua, Irina A. Komissarova
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Patent number: 5518986Abstract: The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as pentachloronitrobenzene, sodium bicarbonate, sodium carbonate, potassium oleate, potassium octanoate and xanthan gum. The combination of potassium oleate, potassium octanoate and xanthan gum functions as an effective spreader-sticker medium for forming an adherent coating on plant foliage surfaces, and for saturating ground soil. The coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: April 6, 1995Date of Patent: May 21, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5518987Abstract: The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as etridiazole, potassium bicarbonate, sodium carbonate, potassium oleate, potassium caprylate and xanthan gum. The combination of potassium oleate, potassium caprylate and xanthan gum functions as an effective spreader-sticker medium for forming an adherent coating on plant foliage surfaces, and for saturating ground soil. The coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: October 3, 1995Date of Patent: May 21, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5519012Abstract: Novel inclusion complexes of racemic 1,4-dihydropyridines and enantiomers thereof of the formula ##STR1## wherein R represents a phenyl group, substituted with nitro, trifluoromethyl, difluoromethoxy group or with one or two halo atoms (especially chlorine),R.sub.1 and R.sub.2, if the same, represent methyl groups and if one of them has the meaning of a 2-aminoethoxymethyl or cyano group, the other represents a methyl group,R.sub.3 and R.sub.4, if different, stand each time for a hydrogen, linear or branched C.sub.1 -C.sub.6 -alkyl, 2-methoxyethyl, 1-(phenylmethyl)-3-piperidinylphenyl, styryl, furyl, piperidino, 4-diphenylmethyl-1-piperazinylethyl, 5-phenyl-3-pirazolyloxy, 1-phenyl-methyl-3-pyrrolidinyl group or a group of the formula ##STR2## or, if the same, stand each time C.sub.1 -C.sub.4 alkyl group, and of acid addition salts thereof with methyl-.beta.-cyclodextrin, hydroxy-ethyl-.beta.-cyclodextrin or hydroxypropyl-.beta.Type: GrantFiled: December 16, 1994Date of Patent: May 21, 1996Assignee: LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d., LjubljanaInventors: Darja Fercej-Temeljotov, Janko Zmitek, Breda Husu-Kovacevic, Sonja Kotnik, Zdenka Jerala-Strukelj
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Patent number: 5516747Abstract: Surfactant mixtures of an alkyl naphthalene sulfonate and an alkyl polyglycoside, wherein the alkyl polyglycoside is present in from 5 to 25% by weight of the surfactant mixture, and aqueous pesticide compositions containing the surfactant mixture.Type: GrantFiled: April 18, 1994Date of Patent: May 14, 1996Assignee: Henkel CorporationInventor: Frank J. Lachut
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Patent number: 5512298Abstract: The present invention relates to hard capsules of cytarabine ocfosfate which is useful as an anti-leukemia drug applicable to oral administration.By providing the cytarabine ocfosfate hard capsule comprising (1) cytarabine ocfosfate, (2) a high molecular compound functioning as a disintegrator and (3) an alkali, there can be provided pharmaceutical preparations having excellent disintegration property and stability. The cytarabine ocfosfate hard capsules are applicable to clinical use.Type: GrantFiled: March 24, 1993Date of Patent: April 30, 1996Assignee: Nippon Kayaku Kabushiki KaishaInventors: Minoru Aoki, Hiroshi Ohtaki, Nobuharu Fukui, Takashi Terada, Minoru Nakada, deceased
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Patent number: 5496861Abstract: Emulsion-containing cosmetic compositions, wherein the emulsion comprises an aqueous dispersion of 15 to 40% solids, by weight, of an enzymatically degraded starch, which starch has been debranched by treatment with an alpha-1,6-D-glucanohydrolase to yield up to 100%, by weight, short chain amylose, are provided herein. Also provided are oil-free cosmetic compositions and cosmetic stick compositions, comprising 1 to 16% enzymatically debranched starch; 2 to 35% water; 35 to 90% hydrophobic base, selected from the group consisting of oil, wax and fat, and 5 to 20% emulsifier(s), with the balance of the compositions comprising one or more adjuncts selected from dye(s), fragrance(s), flavor(s), sunscreen agent(s), opacifier(s), and filler(s). Also provided is a method for formulating a cosmetic stick composition.Type: GrantFiled: January 24, 1994Date of Patent: March 5, 1996Assignee: National Starch and Chemical Investment Holding CorporationInventors: William Rouse, 3, Maria Valles, Gary T. Martino, Chung-Wai Chiu
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Patent number: 5496563Abstract: There is provided a dry gel composition comprising 40% by weight or below of a medicine which can be orally administered, 3% by weight or above of a gelling agent and 5% by weight or below of a binder, which composition is capable of forming a gruel-like aqueous gel composition upon mixing with 2 to 15 parts by weight of water per part by weight of the composition at a temperature of 40.degree. C. or below. The gelling agent usable herein is, for example, pregelatinized starch having a concentration of 50% by weight or above. The medicine which can be orally administered is, for example, cinnarizine. Upon mixing with a predetermined quantity of water, the dry gel composition forms a homogeneous aqueous gel composition having a viscosity of about 100 to 500 cp, which is preferably thixotropic. Even aged people having a weak swallowing function can easily swallow the aqueous gel composition, without causing improper sucking into their tracheas.Type: GrantFiled: February 28, 1994Date of Patent: March 5, 1996Assignee: Showa Yakuhin Kako Co., Ltd.Inventors: Yoji Ito, Yasuo Hirai
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Patent number: 5496568Abstract: The present invention provides an effective method for controlling foliage and root fungus infection in cultivated crops. A fungicide composition in the form of an aqueous formulation which is applied to pre-harvest crops contains ingredients such as propiconazole, sodium bicarbonate, potassium bicarbonate, sodium oleate, sodium caprylate and xanthan gum. The combination of sodium oleate, sodium caprylate and xanthan gum functions as an effective spreader-sticker medium for forming an adherent coating on plant foliage surfaces, and for saturating ground soil. The coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: June 26, 1995Date of Patent: March 5, 1996Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5486508Abstract: A pharmaceutical composition comprising a slightly water-soluble drug, a cyclodextrin and a water-soluble organic solvent is disclosed. The composition improves water-solubility and stability of the slightly water-soluble drug. The pharmaceutical composition is particularly suitable for injection preparations.Type: GrantFiled: April 28, 1994Date of Patent: January 23, 1996Assignee: TAKEDA Chemical Industries Ltd.Inventors: Yoshiaki Uda, Yoko Nishida, Yasuaki Ogawa
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Patent number: 5484601Abstract: A flowable demineralized bone powder composition is provided for use in surgical bone repair.Type: GrantFiled: October 18, 1991Date of Patent: January 16, 1996Assignee: Osteotech, Inc.Inventors: Robert K. O'Leary, Patrick A. McBrayer
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Patent number: 5468716Abstract: The present invention provides a fungicide composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, xanthan gum, dialkylsulfosuccinate salt and alkyl sulfate salt surfactants, and magnesium silicate anti-caking ingredient. The xanthan gum and surfactants function as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications.Type: GrantFiled: October 3, 1994Date of Patent: November 21, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5466461Abstract: New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known are useful as medicaments, for the manufacture of pharmaceutical and cosmetic preparations, in the field of biodegradable plastic materials and, therefore, for the manufacture of medical, surgical and sanitary articles, as well as numerous other industrial sectors in the place of acidic polysaccharides now in common use.Type: GrantFiled: April 2, 1992Date of Patent: November 14, 1995Assignee: Fidia, S.p.A.Inventors: Francesco della Valle, Aurelio Romeo
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Patent number: 5464805Abstract: The present invention provides a method for controlling mildew in cultivated crops. The aqueous fungicide formulation which is applied to pre-harvest and post-harvest crops contains ingredients which are biocompatible for purposes of agricultural and horticultural applications. Illustrative of a formulation which is harmless to animals and humans is an aqueous solution having a content of potassium bicarbonate, potassium carbonate, potassium oleate and xanthan gum. The combination of potassium oleate and xanthan gum functions as an effective spreader-sticker medium for forming a solid coating on plant surfaces. The solid coating exhibits both immediate and long duration fungicidal activities.Type: GrantFiled: March 23, 1995Date of Patent: November 7, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5456923Abstract: The object of this invention is to provide a process for producing a solid dispersion, which has overcome the disadvantages of the conventional production technology for solid dispersions. The invention comprises employing a twin-screw extruder in the production of a solid dispersion. In accordance with the invention, a solid dispersion can be expediently produced without heating a drug and a polymer to or beyond their melting points and without using an organic solvent for dissolving both components and the resulting solid dispersion has excellent performance characteristics.Type: GrantFiled: November 15, 1993Date of Patent: October 10, 1995Assignee: Nippon Shinyaku Company, LimitedInventors: Kouichi Nakamichi, Shogo Izumi, Hiroyuki Yasuura
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Patent number: 5455046Abstract: A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.Type: GrantFiled: September 9, 1993Date of Patent: October 3, 1995Assignee: Edward Mendell Co., Inc.Inventor: Anand R. Baichwal
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Patent number: 5432146Abstract: The present invention provides a fungicidal fertilizer composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An invention fungicide composition in the form of a dry blend formulation remains non-caking and free-flowing under storage conditions. Illustrative of an invention fungicide composition is a formulation which has a content of sodium bicarbonate, potassium bicarbonate, potassium oleate, xanthan gum and a fertilizer-effective content of nitrogen, phosphorus and potassium elements. The combination of potassium oleate and xanthan gum functions as an effective spreader-sticker and film-forming medium when the composition is diluted with water for agricultural applications. When the aqueous medium is hard water, calcium oleate is formed which enhances the sticker properties of the aqueous fungicide composition in agricultural applications.Type: GrantFiled: December 20, 1993Date of Patent: July 11, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5432148Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.Type: GrantFiled: December 7, 1994Date of Patent: July 11, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston
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Patent number: 5425952Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.Type: GrantFiled: October 13, 1993Date of Patent: June 20, 1995Assignee: Church & Dwight Co., Inc.Inventor: Anthony E. Winston