Cellulose Or Derivative Patents (Class 514/781)
  • Patent number: 10927504
    Abstract: A method of producing a microfibrillated cellulose (MFC) film comprising reinforcement fibers. The method includes: providing a suspension comprising a first MFC in an amount of at least 50 weight %, reinforcement fibers in an amount of at least 5 weight %, all percentages calculated on the total solid content of said suspension, and a formation aid; mixing said suspension to form a mixture; forming a fibrous web from the mixture; and dewatering and/or drying said fibrous web to form a film having a basis weight of less than 40 g/m2, a specific formation number of below 0.45 g0.5/m2, and an Oxygen Transmission Rate (OTR) value of below 100 ml/m2/per 24 hours, preferably of below 50 ml/m2per 24 hours at 50% relative humidity. Also, a film and use of the film in food or liquid packaging applications.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: February 23, 2021
    Assignee: Stora Enso OYJ
    Inventors: Kaj Backfolk, Isto Heiskanen, Esa Saukkonen
  • Patent number: 10836840
    Abstract: The present invention relates to the field of hyaluronic acid-based gel compositions suitable for use as soft tissue fillers, and more specifically to a novel method for crosslinking such compositions. The present invention further relates to compositions prepared by the novel crosslinking method and their use in cosmetic and therapeutic applications.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: November 17, 2020
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Wolfgang Liebetrau, Franck Villain
  • Patent number: 10792345
    Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 6, 2020
    Assignee: ALLERGAN, INC.
    Inventors: Ahmet Tezel, Wendy M. Blanda, Patrick M. Hughes, Scott M. Whitcup, James N. Chang, Michael R. Robinson
  • Patent number: 10752863
    Abstract: The present invention is in the field of cleaning compositions. In particular it relates to liquid, gelled or pasty cleaning compositions comprising one or more detergent surfactants. The invention provides cleaning compositions comprising water, one or more detergent surfactants and defibrillated primary cell wall material comprising microfibrils. The invention also relates to a method for preparing a cleaning composition comprising water, one or more detergent surfactants and defibrillated primary cell wall material comprising microfibrils, wherein the method includes a high shear treatment step.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: August 25, 2020
    Assignee: Conopco Inc.
    Inventors: Leonardus Marcus Flendrig, Gerrit Jan Willem Goudappel, Anke Kuijk, Stephanie Lam, Sandra Joyce Veen, Orlin Dimitrov Velev, Krassimir Petkov Velikov, Jan Adrianus Verheij
  • Patent number: 10525432
    Abstract: There is described a versatile and environment-friendly one-pot process for the preparation of nanoparticles of noble metals in hydrogel, obtainable at room temperature using quaternized hydroxyethylcellulose.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 7, 2020
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Anna Luisa Costa, Magda Blosi
  • Patent number: 10500282
    Abstract: A pharmaceutical composition and method of producing supersaturated stabilized nanoparticles of poorly soluble drugs having average sizes less than 1 ?m, or less than 800 nm, or less than 500 nm, comprising at least one pharmaceutically active ingredient, a hydrophilic polymer, a water-soluble surfactant, and subsequently stabilized by ionic polymers.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: December 10, 2019
    Assignee: Kashiv BioSciences, LLC
    Inventors: Dipen Desai, Wantanee Phuapradit, Anekant Jain, Atsawin Thongsukmak, Navnit H. Shah
  • Patent number: 10500421
    Abstract: A composition and method for reducing the drying time of wet hair by about 20 to about 30 percent includes applying a silicone-free, non-aqueous composition comprising about 90 to about 96 percent by weight of a volatile hydrocarbon mixture comprising C13-C16 isoparaffin, C12-C14 isoparaffin; and C13-C15 alkane; about 2 to about 3 percent by weight of ppg-3 benzyl ether myristate; about 0.001 to about 0.01 percent by weight of a sodium laneth 40-maleate/styrene sulfonate copolymer; and about 0.01 to about 0.5 percent by weight of an emollient mixture comprising isostearic acid, sorbitan oleate, cocoyl hydrolyzed keratin and heat to wet hair, thereby removing from about 85% to about 100% of water added to the hair during washing.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: December 10, 2019
    Assignee: KENRA PROFESSIONAL, LLC
    Inventor: Thomas A Lehman
  • Patent number: 10426809
    Abstract: The present invention involves the isolation of plant based CNCs from the leaves of S. cumini. For the formation of NCs, a novel greener approach using S. cumini LE as reducing agent for in situ impregnation of AgNPs as fillers into CNCs as matrix is reported. The silver nitrate solution in three different concentrations of 1 mM, 5 mM and 10 mM was used to form NCs where AgNPs have been incorporated into CNCs matrix. The CNCs and NCs were characterized using SEM, TEM, XRD, Zeta potential, FT-IR, and UV-Vis spectroscopy. NCs developed in the form of film and ointment showed strong antimicrobial activity against both gram negative and gram positive bacteria. NCs wound dressing is capable of regulating wound exudates and providing moisture to wound responsible for faster healing of acute wounds. The observations from histopathological and biochemical assays confirmed that NCs enhance healing because of lesser inflammation, rapid angiogenesis, early collagen formation and enhanced rate of reepithelization.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: October 1, 2019
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sudesh Kumar Yadav, Rubbel Singla, Avnesh Kumari
  • Patent number: 10406107
    Abstract: Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: September 10, 2019
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Naosuke Maruyama, Yasuyuki Hirama
  • Patent number: 10206945
    Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: February 19, 2019
    Assignee: BioInteractions Ltd.
    Inventors: Simon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay Luthra
  • Patent number: 10206883
    Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 19, 2019
    Assignee: Durect Corporation
    Inventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael Zamloot
  • Patent number: 10173357
    Abstract: Extrudable hydrogel compositions for printing 3D objects, such as cell growth scaffolds, are provided. Also provided are methods for making the crosslinked hydrogel compositions and the printed objects and methods for culturing cells using the cell growth scaffolds. The hydrogel precursor solutions are aqueous solutions comprising a biocompatible polymer, functionalized polyethylene glycol as a crosslinker and, optionally, cells and/or bioactive factors.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: January 8, 2019
    Assignee: Northwestern University
    Inventors: Alexandra L. Rutz, Ramille N. Shah
  • Patent number: 10066074
    Abstract: A method of producing, in a liquid, a hollow particulate material having a cavity therein, the method including: (A) blowing gas into a resin solution containing a first dispersion medium; (B) pouring the resin solution to which the gas is blown in step (A) into a second dispersion medium to form liquid droplets encapsulating the gas and prepare a dispersion of the liquid droplets; and (C) solidifying the liquid droplets formed in step (B) and isolating the solidified liquid droplets from the second dispersion medium.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: September 4, 2018
    Assignee: KONICA MINOLTA, INC.
    Inventors: Tomoo Sakimura, Shingo Fujimoto, Kunihiro Ogura
  • Patent number: 10058617
    Abstract: Provided is a composition for forming a film, the composition not having completely dissolved hydroxypropyl methyl cellulose (HPMC), and enabling formation of the film having a uniform thickness by suppressing the viscosity increase of the composition around an immersion temperature of 50° C. More specifically provided is a composition for forming a film, the composition comprising hypromellose having methoxy group content of 28.0 to 30.0% by weight and hydroxypropoxy group content of 7.6 to 8.5% by weight, wherein a 2% by weight aqueous solution of the hypromellose provides a viscosity at 20° C. of 4.0 to 6.5 mPa·s, a 20% by weight dispersion of the hypromellose provides a viscosity at 50° C. of 2,000 to 11,000 mPa·s, and a 20% by weight aqueous solution of the hypromellose provides a gelation temperature of 54 to 57° C.; and a solvent.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: August 28, 2018
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Tatsuya Yamashita, Takuya Yokosawa, Naosuke Maruyama, Mitsuo Narita
  • Patent number: 10016508
    Abstract: Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: July 10, 2018
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Shogo Warashina, Fumie Kusaki, Kazuki Kikuchi, Sakae Obara, Naosuke Maruyama
  • Patent number: 9907741
    Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: March 6, 2018
    Assignee: Luromed LLC
    Inventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
  • Patent number: 9855541
    Abstract: A method for fabricating a three-dimensional network structure material comprises steps: mixing ammonium carboxymethyl cellulose with water or with water and a nanomaterial to form a first gel or a second gel; freeze-drying the first gel or the second gel to sublimate the first gel or the second gel and form a first product or a second product; and heating the first product or the second product at a lower temperature to cure the first product or the second product and obtain a first 3D network structure material or a second 3D network structure material. The present invention uses a simple process using water as the solvent, meeting the environment protection demand and having high economical efficiency. The first and second 3D network structure materials fabricated by the present invention absorb water but do not dissolve in water. Thus, the present invention can be applied to many fields.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: January 2, 2018
    Assignee: Taiwan Carbon Nano Technology Corporation
    Inventors: Chun-Hsien Tsai, Chun-Jung Tsai, Ting-Chuan Lee, Ching-Tung Hsu, Chia-Hung Li, Wan-Ju Chen, Jui-Yu Jao
  • Patent number: 9737538
    Abstract: Disclosed are compositions including a solid dispersion comprising a dispersion polymer, a basic low-water solubility active, and an anionic counterion, as well as methods of making and using the compositions.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: August 22, 2017
    Assignee: Bend Research, Inc.
    Inventors: Warren K. Miller, Michael M. Morgen
  • Patent number: 9666878
    Abstract: A method for fabricating a catalytic 3-dimensional network material comprises steps: mixing an aqueous solvent with a nitrogen-containing carbon material whose surface is doped with nitrogen atoms to form a first dispersion liquid, and mixing the first dispersion liquid with ammonium carboxymethyl cellulose to form a first gel; undertaking a freeze-drying process of the first gel to remove water from the first gel to form a first product; and undertaking a low-temperature heating process of the first product at a temperature of 50-380° C. to cure the first product into a 3D network material doped with nitrogen atoms. The catalytic 3D network material of the present invention has a very high specific surface area to increase the catalytic efficiency.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: May 30, 2017
    Assignee: TAIWAN CARBON NANO TECHNOLOGY CORPORATION
    Inventors: Chun-Hsien Tsai, Ting-Chuan Lee, Chun-Jung Tsai, Ching-Tung Hsu, Chia-Hung Li, Jui-Yu Jao, Wen-Hui Liu, Ya-Han Wu
  • Patent number: 9655861
    Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: May 23, 2017
    Assignee: DURECT CORPORATION
    Inventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael Zamloot
  • Patent number: 9622957
    Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 18, 2017
    Assignee: Allergan, Inc.
    Inventors: Ahmet Tezel, Wendy M. Blanda, Patrick M. Hughes, Scott M. Whitcup, James N. Chang, Michael R. Robinson
  • Patent number: 9592204
    Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 14, 2017
    Assignee: DURECT CORPORATION
    Inventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael Zamloot
  • Patent number: 9308165
    Abstract: The composition for treating ocular effects of diabetes is a composition that contains an aldose reductase inhibitor in an ophthalmic gel for topical application to the eye. The composition includes a carrier having, by weight, about 0.4% carbomer, 4.0% sorbitol, 0.01% centrimide, 0.01% ethylenediaminetetraacetic acid (EDTA) and effective amounts of sodium chloride and sodium hydroxide for adjusting the pH of the topical carrier to about 7 and to achieve a desired viscosity, with the balance being water. The aldose reductase inhibitor (ARI) is mixed with the topical carrier at about 0.1%-6% by weight of the composition to form an ophthalmic gel. Preferably, the ARI is 2R,4S-6-fluoro-2-methyl-spiro[chroman-4,4?-imidazolidine]-2?,5?-dione, referred to as 2-methyl sorbinil, having the structure: or a pharmaceutically acceptable salt thereof. In use, the ophthalmic gel is preferably applied as an eye drop at a dosage of one drop per eye administered two to three times daily.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: April 12, 2016
    Assignee: THERAPEUTIC VISION, INC.
    Inventors: Milton Wyman, Vincent Bellavia
  • Patent number: 9161970
    Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: October 20, 2015
    Assignee: Allergan, Inc.
    Inventors: Ahmet Tezel, Wendy M. Blanda, Patrick M. Hughes, Scott M. Whitcup, James N. Chang, Michael R. Robinson
  • Patent number: 9119785
    Abstract: The present invention relates to a cosmetic basic composition comprising hydroxypropylmethylcellulose (HPMC) modified with C15-C20 alkyl ether groups as thickener, Oleosomes and water, wherein the Oleosomes comprise at least one cosmetically active substance. The invention also relates to the use of the cosmetic basic composition in products of decorative cosmetics, personal care cosmetics and/or skin protection cosmetics.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: September 1, 2015
    Assignee: Coty Germany GmbH
    Inventors: Lethu Nguyen, Salvatore J. Barone, Ralph Macchio
  • Patent number: 9055757
    Abstract: Methods of making a high gel strength, water-dispersible, stabilizing colloidal microcrystalline cellulose composition are disclosed. This stabilizer composition is useful in many food and non-food applications.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: June 16, 2015
    Assignee: FMC Corporation
    Inventors: Zheng Tan, Maurice Gerard Lynch, Thomas Ruszkay, Michael Sestrick
  • Publication number: 20150148431
    Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.
    Type: Application
    Filed: November 21, 2014
    Publication date: May 28, 2015
    Inventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
  • Publication number: 20150140091
    Abstract: A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.
    Type: Application
    Filed: July 12, 2013
    Publication date: May 21, 2015
    Applicant: Dow Global Technologies LLC
    Inventors: Nicholas S. Grasman, Steven J. Guillaudeu, Mark J. Hall, Uma Shrestha, Maureen L. Rose, William W. Porter, III, Wesley J. Spaulding, Kevin P. O'donnell, True L. Rogers
  • Publication number: 20150141517
    Abstract: Provided is a rapid release tablet excellent in binding capability and disintegrability and also excellent in storage stability and the like. More specifically, provided are a granulated composite comprising low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight and D-mannitol, wherein the D-mannitol contains 0.9% by weight or less of D-sorbitol; a rapid release tablet comprising the granulated composite and a drug; and a method for producing a granulated composite comprising the steps of: mixing low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight, first D-mannitol, and water to obtain an aqueous dispersion, and granulating while adding the aqueous dispersion to second D-mannitol, wherein the first D-mannitol and the second D-mannitol contain 0.9% by weight or less of D-sorbitol in total.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 21, 2015
    Inventors: Yasuyuki Hirama, Naosuke Maruyama
  • Patent number: 9034843
    Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) one or more member(s) selected from the group consisting of chondroitin sulfate, alginic acid and salts thereof; and (C) a nonionic surfactant.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: May 19, 2015
    Assignee: Rohto Pharmaceutical Co., Ltd.
    Inventors: Yasuko Matsumura, Kazuhiro Fukushima
  • Patent number: 9017702
    Abstract: A formulation includes one or more active ingredients of poor water solubility for medical or non-medical use in the rearing of animals. The formulation is suitable for administration to the animals via their drinking water. It exhibits superior stability. The formulation comprises an active ingredient, a thickener combination and water, wherein the thickener combination comprises at least one thickener selected from the following groups A, B, C and D: (A) cellulose derivatives, such as methyl cellulose, sodium carboxy methyl cellulose, (B) non-cellulosic polysaccharide thickeners such as xanthan gums, Arabic gum, (C) cross-linked polyacrylic acid polymers, (D) hydrocolloidal hydrated silicates.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: April 28, 2015
    Assignee: KRKA, D.D., Novo Mesto
    Inventors: Denise Leskovar, Franc Vrecer, Andrejka Kramar, Ivanka Kolenc, Ivan Gobec, Helena Princ
  • Publication number: 20150099928
    Abstract: In one aspect, the invention provides injectable compositions that comprise a suitable hydrophilic polymer (e.g., a suitable polysaccharide) and water, as well as other optional components. In various embodiments, the composition may be provided in a suitable container, for example, in a pre-loaded syringe. In another aspect, methods of performing medical procedures in a tract of a body are provided. In yet another aspect, the invention provides systems for performing medical procedures in a tract of a body.
    Type: Application
    Filed: October 7, 2014
    Publication date: April 9, 2015
    Applicant: Boston Scientific Scimed, Inc.
    Inventors: Paul Smith, Felipe Torres, Samuel Raybin, Mary Jo Timm
  • Patent number: 8999305
    Abstract: The invention relates to a composition comprising (1) at least one polar modified polymer, (2) at least one compound selected from a hyperbranched polyol having at least two hydroxyl groups, a sugar silicone surfactant, and a gelling agent.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: April 7, 2015
    Assignee: L'Oreal
    Inventors: Hy Si Bui, Mohamed Kanji, Anita Chon Tong, Chunhua Li, Susan Halpern, Bruno Thierry Bavouzet
  • Patent number: 8986735
    Abstract: A solid dosage form containing a taste masked active agent is provided. The solid dosage form may be provided as a water soluble film that is disintegrable in the oral cavity to deliver and release the taste masked active agent. The disintegrable film includes at least one water soluble polymer and a taste masked ketoprofen active. Also provided are methods for preparing the solid dosage form and for using the solid dosage to administer an effective dosage of an active agent, such as ketoprofen, into the oral cavity for absorption.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 24, 2015
    Assignee: Novartis AG
    Inventors: Alexander M Schobel, Shyam S Vangala
  • Patent number: 8980321
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: March 17, 2015
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Patent number: 8980230
    Abstract: The present invention is directed towards a process for making oral compositions comprising gel networks. The gel networks are formed from a fatty amphiphile dispersion and swelling surfactant. The fatty amphiphile dispersion comprises one or more fatty amphiphiles, one or more dispersing surfactants, and one or more solvents. A gel network is formed when the fatty amphiphile dispersion is combined with the swelling surfactant. A method of preparing the fatty amphiphile dispersion and oral composition is included.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 17, 2015
    Assignee: The Procter & Gamble Company
    Inventors: Michael Jude LeBlanc, George Endel Deckner
  • Patent number: 8980248
    Abstract: This invention provides a polymer composition comprising at least one thermal gelling polymer and at least one anionic polymer for cell delivery applications. These injectable polymer compositions are shear-thinning, thixotropic and resorbable. More specifically there is described a hyaluronan (HA) and methylcellulose (MC) based thermogelling cell delivery system (HAMC) that promotes cell survival both in vitro and in vivo. Importantly, HAMC (relative to media alone) enhances survival of transplanted stem/progenitor cells in the injured CNS. HAMC provides a minimally-invasive cell delivery strategy where the microenvironment can be further defined and the differentiation and regenerative capacity further explored. This hydrogel system has applications for minimally-invasive cell delivery to other tissues/organs in the body as well.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: March 17, 2015
    Assignee: The Governing Council of the University of Toronto
    Inventors: Molly Sandra Shoichet, Tasneem Zahir, Brian Ballios, Derek Van der Kooy, Michael Cooke
  • Patent number: 8980320
    Abstract: A film coating agent for a solid formulation includes a water-soluble cellulose derivative, swelling clay, a cationic surfactant, and a fatty acid, wherein mass ratio of the swelling clay to the water-soluble cellulose derivative is 2:8 to 8:2, and content of the cationic surfactant is not less than 0.5 equivalents and not more than 3.0 equivalents relative to a cation exchange equivalent of the swelling clay.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: March 17, 2015
    Assignee: Toray Industries, Inc.
    Inventors: Ryoji Yoshii, Yuki Hayashi, Yuki Fujisaki
  • Publication number: 20150065548
    Abstract: A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.
    Type: Application
    Filed: April 8, 2013
    Publication date: March 5, 2015
    Inventors: Roland Adden, Robert L. Sammler, Meinolf Brackhagen, Nicholas S. Grasman, Oliver Petermann, Steven J. Guillaudeu
  • Publication number: 20150065547
    Abstract: An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26?0.2*MS(hydroxyalkyl)] is 0.
    Type: Application
    Filed: October 24, 2012
    Publication date: March 5, 2015
    Applicant: Dow Global Technologies LLC
    Inventors: Robert L. Schmitt, Robert L. Sammler, Meinolf Brackhagen, Oliver Petermann, Roland Adden, Nicholas S. Grasman, Steven J. Guillaudeu
  • Patent number: 8968710
    Abstract: A topical anesthetic is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the skin or mucosa. The vehicle for transporting the tetracaine includes a water soluble mucoadhesive or a combination of mucoadhesives such as a high molecular weight poly(ethylene oxide) homopolymer and a cellulose polymer. The vehicle also includes propylene glycol. The tetracaine is ground into a powder and is suspended in a plasticized hydrocarbon gel which completes the vehicle.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 3, 2015
    Inventors: Alan J. Wickenhauser, Stephen E. Peipert
  • Patent number: 8968783
    Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
  • Publication number: 20150057356
    Abstract: A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26?0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.
    Type: Application
    Filed: April 8, 2013
    Publication date: February 26, 2015
    Inventors: Nicholas S. Grasman, True L. Rogers, Oliver Petermann, Meinolf Brackhagen, Roland Adden
  • Patent number: 8962697
    Abstract: The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: February 24, 2015
    Assignee: Interface Biologics Inc.
    Inventors: Frank Laronde, Hanje Chen
  • Publication number: 20150050334
    Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.
    Type: Application
    Filed: August 27, 2014
    Publication date: February 19, 2015
    Inventors: Dominique Nicolas Cade, Xiongwei David He
  • Patent number: 8957116
    Abstract: To provide a solution for forming a double eyelid which enables extremely easy formation of a natural and ideal double eyelid without giving a displeased feeling or an uncomfortable feeling to a user, and a method for forming a double eyelid using the solution for forming a double eyelid. A solution for forming a double eyelid 1 according to the present invention is formed by dissolving, into a solvent having volatility, a fibrous material which forms a film 1a onto a skin 5a of an eyelid 5 and shrinks with vaporization of the solvent. By applying the solution 1, in a successive-curve form, over an imaginary line I forming a fold 5d of a double eyelid in the eyelid 5 onto which a user want to make a fold and vaporizing the solvent so as to shrink the film 1a, successive concaved groove-like constricted part 5c is formed on the imaginary line I and the fold 5d of a double eyelid along the constricted part 5c is formed.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: February 17, 2015
    Inventors: Naoko Iwagaki, Masayuki Kamagata, Jirou Taniyama
  • Publication number: 20150045452
    Abstract: The present application provides an orally-disintegrating tablet having excellent tablet hardness and disintegrability. The present application further provides a method of producing a disintegrative particulate composition including three components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using granules obtained in the first wet granulation step and the remaining one component of the three components not used in the first wet granulation step. The production method may further includes a crystalline cellulose as a fourth component or a third step of mixing a crystalline cellulose into granules obtained in the second wet granulation step. Disintegrative particulate compositions obtained by these methods are also disclosed.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 12, 2015
    Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimko Ikeda, Haruka Wakayama
  • Patent number: 8952057
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 10, 2015
    Assignee: JR Chem, LLC
    Inventor: José E. Ramirez
  • Patent number: 8940800
    Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: January 27, 2015
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
  • Publication number: 20150024054
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.
    Type: Application
    Filed: August 6, 2014
    Publication date: January 22, 2015
    Applicant: BEND RESEARCH, INC.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale