Cellulose Or Derivative Patents (Class 514/781)
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Patent number: 12214084Abstract: An object of the present disclosure is providing a hard capsule made of a hard capsule film having enteric properties that can be molded by a cold gel method. An enteric hard capsule comprises a film containing a first component and a second component, and further containing at least one component selected from the group consisting of a third component, a fourth component, and a fifth component, wherein the first component is a nonionic water-soluble cellulose compound having a viscosity value within a range of from 100 mPa·s to 100,000 mPa·s, the second component is an enteric methacrylic acid copolymer, the third component is an enteric cellulose compound, wherein the fourth component is a water-insoluble (meth)acrylic acid alkyl ester copolymer, and the fifth component is at least one kind selected from the group consisting of polyvinyl alcohol, a plasticizer, and a surfactant.Type: GrantFiled: July 11, 2018Date of Patent: February 4, 2025Assignee: QUALICAPS CO., LTD.Inventors: Yoshiro Osaki, Makoto Aso, Toshimitsu Usui, Mamoru Honda
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Patent number: 11786561Abstract: A composition and a kit comprising a nitrite source admixed with a gelling agent for nitric oxide production. Also disclosed is a method for generating nitric oxide, which finds applications in the treatment of various diseases.Type: GrantFiled: September 19, 2022Date of Patent: October 17, 2023Assignee: Albert Einstein College of MedicineInventor: Joel M. Friedman
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Patent number: 11702641Abstract: The purpose of the present invention is to provide a steviol glycoside hexose transferase, and a method for producing a steviol glycoside that contains glucose and/or rhamnose using said enzyme. The present invention provides a steviol glycoside hexose transferase, and a method for producing a steviol glycoside that contains glucose and/or rhamnose using said enzyme. The present invention also provides a transformant into which a steviol glycoside hexose transferase gene has been introduced, and a method for preparing said transformant.Type: GrantFiled: December 26, 2017Date of Patent: July 18, 2023Assignee: SUNTORY HOLDINGS LIMITEDInventors: Eiichiro Ono, Misa Ochiai, Kazunari Iwaki, Tadayoshi Hirai
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Patent number: 11602153Abstract: This invention relates to making and using a stabilizer that is effective in small amounts and, particularly useful for stabilizing low solids liquids, e.g., dispersions, emulsions, and suspensions, used in foods, pharmaceuticals, nutraceuticals, and similar industrial applications, which comprises, microcrystalline cellulose, (preferably, colloidal hydrolyzed MCC); a first carboxymethyl cellulose having a viscosity of 30-85 cP at 2% in deionized water; and, a degree of carboxymethyl substitutions of 0.60 to 0.85, and a second carboxymethyl cellulose having a viscosity of 400-800 cP at 2% in deionized water, and a degree of carboxymethyl substitutions of 0.80 to 0.Type: GrantFiled: August 11, 2017Date of Patent: March 14, 2023Assignee: DUPONT NUTRITION USA, INC.Inventors: Zheng Tan, Mei Yan Joyce Toh, Simon Patrick Charles Eustace, Jeremy Ondov
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Patent number: 11534526Abstract: The present application relates to a medical hydrogel comprising nanofibrillar cellulose, wherein the hydrogel has a viscosity in the range of 2500-9000 Pa·s and a water retention value in the range of 30-100 g/g. The present application also relates to a method for preparing the medical hydrogel The present application relates to the medical hydrogel for use for treating wounds.Type: GrantFiled: December 14, 2017Date of Patent: December 27, 2022Assignee: UPM-KYMMENE CORPORATIONInventors: Kari Luukko, Markus Nuopponen
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Patent number: 11421043Abstract: There is provides a method for producing sieved low-substituted hydroxypropyl cellulose (L-HPC) at improved yield, while maintaining flowability and tablet properties. More specifically, there is provided a method for producing sieved L-HPC including a first sieving step of sieving L-HPC having a hydroxypropoxy group content of 5 to 16% by mass with a sieving shaker with horizontal movement of a sieve surface to obtain first sieve-residual L-HPC and first sieve-passed L-HPC, a second sieving step of sieving the first sieve-residual L-HPC with a sieving shaker with vertical movement of a sieve surface to obtain second sieve-residual L-HPC and second sieve-passed L-HPC, and a step of combining the first sieve-passed L-HPC and the second sieve-residual L-HPC to obtain the sieved L-HPC.Type: GrantFiled: August 24, 2020Date of Patent: August 23, 2022Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Kentaro Miki, Akiko Tsuchida, Akira Kitamura, Yasuyuki Hirama
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Patent number: 11103505Abstract: Provided are solid dispersions of Compound I having the formula: wherein Compound I is substantially amorphous, methods of manufacturing said solid dispersions, and methods of using said solid dispersions.Type: GrantFiled: October 26, 2018Date of Patent: August 31, 2021Assignee: Plexxikon Inc.Inventors: Hamid Rezaei, Marika Nespi, Prabha N. Ibrahim, Gary Conard Visor
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Patent number: 11058802Abstract: A non-synthetic, hydrophilic, biodegradable, biocompatible polysaccharide based non-toxic anti-adhesion hydrogel barrier is disclosed herein. The barrier of the present invention is formed by constructing a unique interpenetrating, crosslinked network with a unique porosity. Furthermore, the barrier of the present invention is comprised of tunable biopolymers for controllable mechanical robustness and degradation. The barrier of the present invention effectively reduces unwanted adhesions using non-synthetic components.Type: GrantFiled: May 1, 2019Date of Patent: July 13, 2021Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Sarah Mayes, Christine E. Schmidt
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Patent number: 10927504Abstract: A method of producing a microfibrillated cellulose (MFC) film comprising reinforcement fibers. The method includes: providing a suspension comprising a first MFC in an amount of at least 50 weight %, reinforcement fibers in an amount of at least 5 weight %, all percentages calculated on the total solid content of said suspension, and a formation aid; mixing said suspension to form a mixture; forming a fibrous web from the mixture; and dewatering and/or drying said fibrous web to form a film having a basis weight of less than 40 g/m2, a specific formation number of below 0.45 g0.5/m2, and an Oxygen Transmission Rate (OTR) value of below 100 ml/m2/per 24 hours, preferably of below 50 ml/m2per 24 hours at 50% relative humidity. Also, a film and use of the film in food or liquid packaging applications.Type: GrantFiled: June 20, 2017Date of Patent: February 23, 2021Assignee: Stora Enso OYJInventors: Kaj Backfolk, Isto Heiskanen, Esa Saukkonen
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Patent number: 10836840Abstract: The present invention relates to the field of hyaluronic acid-based gel compositions suitable for use as soft tissue fillers, and more specifically to a novel method for crosslinking such compositions. The present invention further relates to compositions prepared by the novel crosslinking method and their use in cosmetic and therapeutic applications.Type: GrantFiled: June 29, 2016Date of Patent: November 17, 2020Assignee: Merz Pharma GmbH & Co. KGaAInventors: Wolfgang Liebetrau, Franck Villain
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Patent number: 10792345Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.Type: GrantFiled: April 17, 2017Date of Patent: October 6, 2020Assignee: ALLERGAN, INC.Inventors: Ahmet Tezel, Wendy M. Blanda, Patrick M. Hughes, Scott M. Whitcup, James N. Chang, Michael R. Robinson
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Patent number: 10752863Abstract: The present invention is in the field of cleaning compositions. In particular it relates to liquid, gelled or pasty cleaning compositions comprising one or more detergent surfactants. The invention provides cleaning compositions comprising water, one or more detergent surfactants and defibrillated primary cell wall material comprising microfibrils. The invention also relates to a method for preparing a cleaning composition comprising water, one or more detergent surfactants and defibrillated primary cell wall material comprising microfibrils, wherein the method includes a high shear treatment step.Type: GrantFiled: December 22, 2015Date of Patent: August 25, 2020Assignee: Conopco Inc.Inventors: Leonardus Marcus Flendrig, Gerrit Jan Willem Goudappel, Anke Kuijk, Stephanie Lam, Sandra Joyce Veen, Orlin Dimitrov Velev, Krassimir Petkov Velikov, Jan Adrianus Verheij
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Patent number: 10525432Abstract: There is described a versatile and environment-friendly one-pot process for the preparation of nanoparticles of noble metals in hydrogel, obtainable at room temperature using quaternized hydroxyethylcellulose.Type: GrantFiled: February 1, 2016Date of Patent: January 7, 2020Assignee: CONSIGLIO NAZIONALE DELLE RICERCHEInventors: Anna Luisa Costa, Magda Blosi
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Patent number: 10500282Abstract: A pharmaceutical composition and method of producing supersaturated stabilized nanoparticles of poorly soluble drugs having average sizes less than 1 ?m, or less than 800 nm, or less than 500 nm, comprising at least one pharmaceutically active ingredient, a hydrophilic polymer, a water-soluble surfactant, and subsequently stabilized by ionic polymers.Type: GrantFiled: December 19, 2013Date of Patent: December 10, 2019Assignee: Kashiv BioSciences, LLCInventors: Dipen Desai, Wantanee Phuapradit, Anekant Jain, Atsawin Thongsukmak, Navnit H. Shah
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Patent number: 10500421Abstract: A composition and method for reducing the drying time of wet hair by about 20 to about 30 percent includes applying a silicone-free, non-aqueous composition comprising about 90 to about 96 percent by weight of a volatile hydrocarbon mixture comprising C13-C16 isoparaffin, C12-C14 isoparaffin; and C13-C15 alkane; about 2 to about 3 percent by weight of ppg-3 benzyl ether myristate; about 0.001 to about 0.01 percent by weight of a sodium laneth 40-maleate/styrene sulfonate copolymer; and about 0.01 to about 0.5 percent by weight of an emollient mixture comprising isostearic acid, sorbitan oleate, cocoyl hydrolyzed keratin and heat to wet hair, thereby removing from about 85% to about 100% of water added to the hair during washing.Type: GrantFiled: November 1, 2013Date of Patent: December 10, 2019Assignee: KENRA PROFESSIONAL, LLCInventor: Thomas A Lehman
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Patent number: 10426809Abstract: The present invention involves the isolation of plant based CNCs from the leaves of S. cumini. For the formation of NCs, a novel greener approach using S. cumini LE as reducing agent for in situ impregnation of AgNPs as fillers into CNCs as matrix is reported. The silver nitrate solution in three different concentrations of 1 mM, 5 mM and 10 mM was used to form NCs where AgNPs have been incorporated into CNCs matrix. The CNCs and NCs were characterized using SEM, TEM, XRD, Zeta potential, FT-IR, and UV-Vis spectroscopy. NCs developed in the form of film and ointment showed strong antimicrobial activity against both gram negative and gram positive bacteria. NCs wound dressing is capable of regulating wound exudates and providing moisture to wound responsible for faster healing of acute wounds. The observations from histopathological and biochemical assays confirmed that NCs enhance healing because of lesser inflammation, rapid angiogenesis, early collagen formation and enhanced rate of reepithelization.Type: GrantFiled: January 12, 2017Date of Patent: October 1, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Sudesh Kumar Yadav, Rubbel Singla, Avnesh Kumari
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Patent number: 10406107Abstract: Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.Type: GrantFiled: June 4, 2013Date of Patent: September 10, 2019Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Naosuke Maruyama, Yasuyuki Hirama
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Patent number: 10206883Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.Type: GrantFiled: December 12, 2017Date of Patent: February 19, 2019Assignee: Durect CorporationInventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael Zamloot
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Patent number: 10206945Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.Type: GrantFiled: April 28, 2014Date of Patent: February 19, 2019Assignee: BioInteractions Ltd.Inventors: Simon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay Luthra
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Patent number: 10173357Abstract: Extrudable hydrogel compositions for printing 3D objects, such as cell growth scaffolds, are provided. Also provided are methods for making the crosslinked hydrogel compositions and the printed objects and methods for culturing cells using the cell growth scaffolds. The hydrogel precursor solutions are aqueous solutions comprising a biocompatible polymer, functionalized polyethylene glycol as a crosslinker and, optionally, cells and/or bioactive factors.Type: GrantFiled: September 25, 2014Date of Patent: January 8, 2019Assignee: Northwestern UniversityInventors: Alexandra L. Rutz, Ramille N. Shah
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Patent number: 10066074Abstract: A method of producing, in a liquid, a hollow particulate material having a cavity therein, the method including: (A) blowing gas into a resin solution containing a first dispersion medium; (B) pouring the resin solution to which the gas is blown in step (A) into a second dispersion medium to form liquid droplets encapsulating the gas and prepare a dispersion of the liquid droplets; and (C) solidifying the liquid droplets formed in step (B) and isolating the solidified liquid droplets from the second dispersion medium.Type: GrantFiled: January 12, 2016Date of Patent: September 4, 2018Assignee: KONICA MINOLTA, INC.Inventors: Tomoo Sakimura, Shingo Fujimoto, Kunihiro Ogura
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Patent number: 10058617Abstract: Provided is a composition for forming a film, the composition not having completely dissolved hydroxypropyl methyl cellulose (HPMC), and enabling formation of the film having a uniform thickness by suppressing the viscosity increase of the composition around an immersion temperature of 50° C. More specifically provided is a composition for forming a film, the composition comprising hypromellose having methoxy group content of 28.0 to 30.0% by weight and hydroxypropoxy group content of 7.6 to 8.5% by weight, wherein a 2% by weight aqueous solution of the hypromellose provides a viscosity at 20° C. of 4.0 to 6.5 mPa·s, a 20% by weight dispersion of the hypromellose provides a viscosity at 50° C. of 2,000 to 11,000 mPa·s, and a 20% by weight aqueous solution of the hypromellose provides a gelation temperature of 54 to 57° C.; and a solvent.Type: GrantFiled: December 13, 2016Date of Patent: August 28, 2018Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Tatsuya Yamashita, Takuya Yokosawa, Naosuke Maruyama, Mitsuo Narita
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Patent number: 10016508Abstract: Provided are a composition for hot-melt extrusion which can be hot-melt extruded at a temperature lower than a conventional temperature and therefore free of heat-induced deactivation of a drug; and a method for producing a hot-melt extrusion product which is simpler than a spray-drying method. More specifically, provided is a composition for hot-melt extrusion including a drug and hypromellose acetate succinate (HPMCAS) having a hydroxypropoxy molar substitution of 0.40 or more. Also provided is a method for producing a hot-melt extrusion product including a step of hot-melt extruding a composition for hot-melt extrusion including a drug and hypromellose acetate succinate having a hydroxypropoxy molar substitution of 0.40 or more at a hot-melt temperature of melting temperature of the hypromellose acetate succinate or higher, or at a hot-melt temperature equal to or higher than a temperature at which both the hypromellose acetate succinate and the drug become melted.Type: GrantFiled: June 3, 2014Date of Patent: July 10, 2018Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Shogo Warashina, Fumie Kusaki, Kazuki Kikuchi, Sakae Obara, Naosuke Maruyama
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Patent number: 9907741Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.Type: GrantFiled: February 11, 2016Date of Patent: March 6, 2018Assignee: Luromed LLCInventors: Adelya K. Leshchiner, Nancy E. Larsen, Edward G. Parent
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Patent number: 9855541Abstract: A method for fabricating a three-dimensional network structure material comprises steps: mixing ammonium carboxymethyl cellulose with water or with water and a nanomaterial to form a first gel or a second gel; freeze-drying the first gel or the second gel to sublimate the first gel or the second gel and form a first product or a second product; and heating the first product or the second product at a lower temperature to cure the first product or the second product and obtain a first 3D network structure material or a second 3D network structure material. The present invention uses a simple process using water as the solvent, meeting the environment protection demand and having high economical efficiency. The first and second 3D network structure materials fabricated by the present invention absorb water but do not dissolve in water. Thus, the present invention can be applied to many fields.Type: GrantFiled: October 17, 2014Date of Patent: January 2, 2018Assignee: Taiwan Carbon Nano Technology CorporationInventors: Chun-Hsien Tsai, Chun-Jung Tsai, Ting-Chuan Lee, Ching-Tung Hsu, Chia-Hung Li, Wan-Ju Chen, Jui-Yu Jao
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Patent number: 9737538Abstract: Disclosed are compositions including a solid dispersion comprising a dispersion polymer, a basic low-water solubility active, and an anionic counterion, as well as methods of making and using the compositions.Type: GrantFiled: February 12, 2014Date of Patent: August 22, 2017Assignee: Bend Research, Inc.Inventors: Warren K. Miller, Michael M. Morgen
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Patent number: 9666878Abstract: A method for fabricating a catalytic 3-dimensional network material comprises steps: mixing an aqueous solvent with a nitrogen-containing carbon material whose surface is doped with nitrogen atoms to form a first dispersion liquid, and mixing the first dispersion liquid with ammonium carboxymethyl cellulose to form a first gel; undertaking a freeze-drying process of the first gel to remove water from the first gel to form a first product; and undertaking a low-temperature heating process of the first product at a temperature of 50-380° C. to cure the first product into a 3D network material doped with nitrogen atoms. The catalytic 3D network material of the present invention has a very high specific surface area to increase the catalytic efficiency.Type: GrantFiled: July 16, 2015Date of Patent: May 30, 2017Assignee: TAIWAN CARBON NANO TECHNOLOGY CORPORATIONInventors: Chun-Hsien Tsai, Ting-Chuan Lee, Chun-Jung Tsai, Ching-Tung Hsu, Chia-Hung Li, Jui-Yu Jao, Wen-Hui Liu, Ya-Han Wu
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Patent number: 9655861Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.Type: GrantFiled: July 13, 2015Date of Patent: May 23, 2017Assignee: DURECT CORPORATIONInventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael Zamloot
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Patent number: 9622957Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.Type: GrantFiled: October 19, 2015Date of Patent: April 18, 2017Assignee: Allergan, Inc.Inventors: Ahmet Tezel, Wendy M. Blanda, Patrick M. Hughes, Scott M. Whitcup, James N. Chang, Michael R. Robinson
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Patent number: 9592204Abstract: Abuse-resistant oral dosage forms suitable for administration of pharmacologically active agents are provided.Type: GrantFiled: March 5, 2013Date of Patent: March 14, 2017Assignee: DURECT CORPORATIONInventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael Zamloot
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Patent number: 9308165Abstract: The composition for treating ocular effects of diabetes is a composition that contains an aldose reductase inhibitor in an ophthalmic gel for topical application to the eye. The composition includes a carrier having, by weight, about 0.4% carbomer, 4.0% sorbitol, 0.01% centrimide, 0.01% ethylenediaminetetraacetic acid (EDTA) and effective amounts of sodium chloride and sodium hydroxide for adjusting the pH of the topical carrier to about 7 and to achieve a desired viscosity, with the balance being water. The aldose reductase inhibitor (ARI) is mixed with the topical carrier at about 0.1%-6% by weight of the composition to form an ophthalmic gel. Preferably, the ARI is 2R,4S-6-fluoro-2-methyl-spiro[chroman-4,4?-imidazolidine]-2?,5?-dione, referred to as 2-methyl sorbinil, having the structure: or a pharmaceutically acceptable salt thereof. In use, the ophthalmic gel is preferably applied as an eye drop at a dosage of one drop per eye administered two to three times daily.Type: GrantFiled: August 22, 2013Date of Patent: April 12, 2016Assignee: THERAPEUTIC VISION, INC.Inventors: Milton Wyman, Vincent Bellavia
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Patent number: 9161970Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.Type: GrantFiled: December 12, 2007Date of Patent: October 20, 2015Assignee: Allergan, Inc.Inventors: Ahmet Tezel, Wendy M. Blanda, Patrick M. Hughes, Scott M. Whitcup, James N. Chang, Michael R. Robinson
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Patent number: 9119785Abstract: The present invention relates to a cosmetic basic composition comprising hydroxypropylmethylcellulose (HPMC) modified with C15-C20 alkyl ether groups as thickener, Oleosomes and water, wherein the Oleosomes comprise at least one cosmetically active substance. The invention also relates to the use of the cosmetic basic composition in products of decorative cosmetics, personal care cosmetics and/or skin protection cosmetics.Type: GrantFiled: March 9, 2010Date of Patent: September 1, 2015Assignee: Coty Germany GmbHInventors: Lethu Nguyen, Salvatore J. Barone, Ralph Macchio
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Patent number: 9055757Abstract: Methods of making a high gel strength, water-dispersible, stabilizing colloidal microcrystalline cellulose composition are disclosed. This stabilizer composition is useful in many food and non-food applications.Type: GrantFiled: October 4, 2012Date of Patent: June 16, 2015Assignee: FMC CorporationInventors: Zheng Tan, Maurice Gerard Lynch, Thomas Ruszkay, Michael Sestrick
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Publication number: 20150148431Abstract: A composition suitable for use in a transdermal delivery patch for administration of a biologically active compound, the composition comprising a phosphate compound of tocopherol and a polymer carrier.Type: ApplicationFiled: November 21, 2014Publication date: May 28, 2015Inventors: Jeremy Cottrell, Giacinto Gaetano, Mahmoud El-Tamimy, Nicholas Kennedy, Paul David Gavin
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Publication number: 20150140091Abstract: A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.Type: ApplicationFiled: July 12, 2013Publication date: May 21, 2015Applicant: Dow Global Technologies LLCInventors: Nicholas S. Grasman, Steven J. Guillaudeu, Mark J. Hall, Uma Shrestha, Maureen L. Rose, William W. Porter, III, Wesley J. Spaulding, Kevin P. O'donnell, True L. Rogers
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Publication number: 20150141517Abstract: Provided is a rapid release tablet excellent in binding capability and disintegrability and also excellent in storage stability and the like. More specifically, provided are a granulated composite comprising low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight and D-mannitol, wherein the D-mannitol contains 0.9% by weight or less of D-sorbitol; a rapid release tablet comprising the granulated composite and a drug; and a method for producing a granulated composite comprising the steps of: mixing low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight, first D-mannitol, and water to obtain an aqueous dispersion, and granulating while adding the aqueous dispersion to second D-mannitol, wherein the first D-mannitol and the second D-mannitol contain 0.9% by weight or less of D-sorbitol in total.Type: ApplicationFiled: November 6, 2014Publication date: May 21, 2015Inventors: Yasuyuki Hirama, Naosuke Maruyama
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Patent number: 9034843Abstract: The present invention provides an ophthalmic composition which stabilizes the tear film during wearing contact lens, prevents eye dryness, imparts a favorable sensation in using, is highly convenient with no risk of misuse and shows a high efficiency in the course from manufacturing to sales. More specifically, the present invention provides a wetting solution—eye drops for contact lenses comprising (A) one or more member(s) selected from the group consisting of a cellulose-based polymer, a vinyl-based polymer, polyethylene glycol and dextran; and (B) one or more member(s) selected from the group consisting of chondroitin sulfate, alginic acid and salts thereof; and (C) a nonionic surfactant.Type: GrantFiled: September 11, 2008Date of Patent: May 19, 2015Assignee: Rohto Pharmaceutical Co., Ltd.Inventors: Yasuko Matsumura, Kazuhiro Fukushima
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Patent number: 9017702Abstract: A formulation includes one or more active ingredients of poor water solubility for medical or non-medical use in the rearing of animals. The formulation is suitable for administration to the animals via their drinking water. It exhibits superior stability. The formulation comprises an active ingredient, a thickener combination and water, wherein the thickener combination comprises at least one thickener selected from the following groups A, B, C and D: (A) cellulose derivatives, such as methyl cellulose, sodium carboxy methyl cellulose, (B) non-cellulosic polysaccharide thickeners such as xanthan gums, Arabic gum, (C) cross-linked polyacrylic acid polymers, (D) hydrocolloidal hydrated silicates.Type: GrantFiled: July 6, 2011Date of Patent: April 28, 2015Assignee: KRKA, D.D., Novo MestoInventors: Denise Leskovar, Franc Vrecer, Andrejka Kramar, Ivanka Kolenc, Ivan Gobec, Helena Princ
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Publication number: 20150099928Abstract: In one aspect, the invention provides injectable compositions that comprise a suitable hydrophilic polymer (e.g., a suitable polysaccharide) and water, as well as other optional components. In various embodiments, the composition may be provided in a suitable container, for example, in a pre-loaded syringe. In another aspect, methods of performing medical procedures in a tract of a body are provided. In yet another aspect, the invention provides systems for performing medical procedures in a tract of a body.Type: ApplicationFiled: October 7, 2014Publication date: April 9, 2015Applicant: Boston Scientific Scimed, Inc.Inventors: Paul Smith, Felipe Torres, Samuel Raybin, Mary Jo Timm
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Patent number: 8999305Abstract: The invention relates to a composition comprising (1) at least one polar modified polymer, (2) at least one compound selected from a hyperbranched polyol having at least two hydroxyl groups, a sugar silicone surfactant, and a gelling agent.Type: GrantFiled: June 29, 2010Date of Patent: April 7, 2015Assignee: L'OrealInventors: Hy Si Bui, Mohamed Kanji, Anita Chon Tong, Chunhua Li, Susan Halpern, Bruno Thierry Bavouzet
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Patent number: 8986735Abstract: A solid dosage form containing a taste masked active agent is provided. The solid dosage form may be provided as a water soluble film that is disintegrable in the oral cavity to deliver and release the taste masked active agent. The disintegrable film includes at least one water soluble polymer and a taste masked ketoprofen active. Also provided are methods for preparing the solid dosage form and for using the solid dosage to administer an effective dosage of an active agent, such as ketoprofen, into the oral cavity for absorption.Type: GrantFiled: March 15, 2007Date of Patent: March 24, 2015Assignee: Novartis AGInventors: Alexander M Schobel, Shyam S Vangala
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Patent number: 8980321Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.Type: GrantFiled: July 14, 2014Date of Patent: March 17, 2015Assignee: Bend Research, Inc.Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
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Patent number: 8980320Abstract: A film coating agent for a solid formulation includes a water-soluble cellulose derivative, swelling clay, a cationic surfactant, and a fatty acid, wherein mass ratio of the swelling clay to the water-soluble cellulose derivative is 2:8 to 8:2, and content of the cationic surfactant is not less than 0.5 equivalents and not more than 3.0 equivalents relative to a cation exchange equivalent of the swelling clay.Type: GrantFiled: November 30, 2010Date of Patent: March 17, 2015Assignee: Toray Industries, Inc.Inventors: Ryoji Yoshii, Yuki Hayashi, Yuki Fujisaki
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Patent number: 8980230Abstract: The present invention is directed towards a process for making oral compositions comprising gel networks. The gel networks are formed from a fatty amphiphile dispersion and swelling surfactant. The fatty amphiphile dispersion comprises one or more fatty amphiphiles, one or more dispersing surfactants, and one or more solvents. A gel network is formed when the fatty amphiphile dispersion is combined with the swelling surfactant. A method of preparing the fatty amphiphile dispersion and oral composition is included.Type: GrantFiled: March 14, 2013Date of Patent: March 17, 2015Assignee: The Procter & Gamble CompanyInventors: Michael Jude LeBlanc, George Endel Deckner
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Patent number: 8980248Abstract: This invention provides a polymer composition comprising at least one thermal gelling polymer and at least one anionic polymer for cell delivery applications. These injectable polymer compositions are shear-thinning, thixotropic and resorbable. More specifically there is described a hyaluronan (HA) and methylcellulose (MC) based thermogelling cell delivery system (HAMC) that promotes cell survival both in vitro and in vivo. Importantly, HAMC (relative to media alone) enhances survival of transplanted stem/progenitor cells in the injured CNS. HAMC provides a minimally-invasive cell delivery strategy where the microenvironment can be further defined and the differentiation and regenerative capacity further explored. This hydrogel system has applications for minimally-invasive cell delivery to other tissues/organs in the body as well.Type: GrantFiled: December 17, 2010Date of Patent: March 17, 2015Assignee: The Governing Council of the University of TorontoInventors: Molly Sandra Shoichet, Tasneem Zahir, Brian Ballios, Derek Van der Kooy, Michael Cooke
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Publication number: 20150065548Abstract: A liquid composition comprises an organic diluent and at least one cellulose ether having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group. The liquid composition can be used for preparing a solid dispersion of an active ingredient in a cellulose ether.Type: ApplicationFiled: April 8, 2013Publication date: March 5, 2015Inventors: Roland Adden, Robert L. Sammler, Meinolf Brackhagen, Nicholas S. Grasman, Oliver Petermann, Steven J. Guillaudeu
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Publication number: 20150065547Abstract: An esterified cellulose ether comprises (i) aliphatic monovalent acyl groups or (ii) groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation or (iii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the esterified cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26?0.2*MS(hydroxyalkyl)] is 0.Type: ApplicationFiled: October 24, 2012Publication date: March 5, 2015Applicant: Dow Global Technologies LLCInventors: Robert L. Schmitt, Robert L. Sammler, Meinolf Brackhagen, Oliver Petermann, Roland Adden, Nicholas S. Grasman, Steven J. Guillaudeu
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Patent number: RE49522Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.Type: GrantFiled: February 11, 2021Date of Patent: May 9, 2023Assignee: BIOINTERACTIONS LTD.Inventors: Simon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay Luthra
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Patent number: RE49528Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.Type: GrantFiled: April 23, 2020Date of Patent: May 16, 2023Assignee: BIOINTERACTIONS LTD.Inventors: Simon Jon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay K Luthra