Cellulose Or Derivative Patents (Class 514/781)
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Patent number: 8409621Abstract: A method of forming particles, comprises accelerating a first stream comprising a first liquid, applying a charging voltage of at most 1.5 kV to the first stream, and vibrating the first stream, to form particles.Type: GrantFiled: November 13, 2007Date of Patent: April 2, 2013Assignee: The Board of Trustees of the University of IllinoisInventors: Kyekyoon Kim, Hyungsoo Choi, Young Bin Choy
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Patent number: 8409610Abstract: A wound care device for local treatment of pain in a wound, said device comprising an active pain relieving composition, the device being constructed in such a manner that the pain killing agent is released to the wound in such a way that substantially no effective systemic plasma concentration of the pain killing agent can be found and wherein a majority of said pain killing agent is in direct contact with the wound.Type: GrantFiled: September 12, 2011Date of Patent: April 2, 2013Assignee: Coloplast A/SInventors: Gitte Juel Friis, Truels Sterm Larsen
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Publication number: 20130072579Abstract: A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.Type: ApplicationFiled: February 21, 2011Publication date: March 21, 2013Applicant: SAMSUNG FINE CHEMICALS CO., LTD.Inventors: Jin Ryul Son, Hyon Ho Baek, Eun Hee Park, Sung Wan Lee, Min Gyu Song, Ja Hyun Cha, Jae Uk Cha, Won Hwa Ko
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Publication number: 20130058875Abstract: The present invention is directed to a capsule comprising a water-soluble compound suitable for the capsule, a non-water soluble excipient suitable for the capsule; and suitable for the capsule, and a mixture of colorant agents, wherein the color of the capsule may be in the range of 15<L<90; ?30<a<+75; ?37<b<+46 as measured in accordance with the Lab color space. The present invention further includes capsules containing a filling such as food, medicine, cosmetics, agrichemicals, feed or active biological ingredient.Type: ApplicationFiled: October 17, 2011Publication date: March 7, 2013Inventors: Cale E. Murray, Juan Carlos Arriola Diaz
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Publication number: 20130053374Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polyester. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polyester increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as PEG, Polysorbate, HPMC or HEC, and beta-blockers, such as Carteolol, Levobunolol, Betaxolol, Metipranolol, Timolol or Propranolol. The concentration of the hyperbranched polyester in the ophthalmic formulation should be less than or equal to 4% (w/v) in order to avoid any cytotoxic effects on human corneal cells and thus the eye irritation.Type: ApplicationFiled: May 4, 2011Publication date: February 28, 2013Inventors: Jun Inoue, Tapan Shah
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Publication number: 20130053454Abstract: The present invention relates to a process for the production of a composition wherein the process comprises pre-treating cellulosic fibers by mechanical, chemical and/or enzymatic treatment, mixing the pre-treated cellulosic fibers with pigments forming a dispersion and dispersing the dispersion of pre-treated cellulosic fibers and pigments whereby a composition comprising microfibrillated cellulose is formed. The invention further relates to a composition produced according to the process.Type: ApplicationFiled: May 11, 2011Publication date: February 28, 2013Applicant: Stora Enso OYJInventors: Isto Heiskanen, Kaj Backfolk
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Publication number: 20130045182Abstract: Polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.Type: ApplicationFiled: November 5, 2010Publication date: February 21, 2013Inventors: Glen Gong, Suresh Subraya Pai, Scott Robert Sershen
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Patent number: 8372836Abstract: Pharmaceutical compositions comprising a poorly water soluble ionizable drug, a cationic species and a dispersion polymer are disclosed, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg/ml, in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5. At least 90 wt % of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species, and the dispersion polymer constitute at least 80 wt % of the solid dispersion.Type: GrantFiled: October 8, 2007Date of Patent: February 12, 2013Assignee: Bend Research, Inc.Inventors: Rodney James Ketner, Douglas Alan Lorenz, David Keith Lyon
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Patent number: 8367116Abstract: The invention provides compositions and methods for treating a subject who has suffered from a central nervous system disorder. More particularly, the invention provides sustained polymeric drug delivery systems having a polymer particle, a therapeutic agent, and a buoyancy agent for direct delivery of therapeutic agents into the central nervous system.Type: GrantFiled: March 18, 2011Date of Patent: February 5, 2013Assignee: Seacoast Neuroscience, Inc.Inventors: Daniel Pratt, Samuel S. Macausland, Keith Baker
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Patent number: 8362088Abstract: An apparatus, system, and method are disclosed for encapsulating a homeopathic ingredient with a second ingredient. A homeopathic carrier is prepared by applying the homeopathic ingredient to at least one element. The element is selected from the second ingredient, an excipient, and a capsule assembly. The second ingredient is encapsulated in a closed capsule assembly. The closed capsule assembly comprises the homeopathic carrier.Type: GrantFiled: December 13, 2007Date of Patent: January 29, 2013Inventors: W. Matthew Warnock, Shane Hinze
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Publication number: 20130018112Abstract: A cellulose aerogel comprises a plurality of cellulose nanoparticles. The cellulose nanoparticles preferably comprise at least 50% or 80% cellulose nanocrystals by weight of cellulose nanoparticles, and the cellulose nanoparticle aerogel preferably has a density of from 0.001 to 0.2 g/cm3 or from 0.2 to 1.59 g/cm3 The cellulose nanoparticle aerogel typically has an average pore diameter of less than 100 nmm and the cellulose nanoparticles may comprise anionic and/or cationic surface groups.Type: ApplicationFiled: September 14, 2010Publication date: January 17, 2013Applicant: University of NottinghamInventors: Wim Albert Wilfried Irene Thielemans, Rebecca Davies
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Publication number: 20130017232Abstract: The disclosure provides Bone-mimetic mineral/polymer composite materials useful for formation of artificial bone grafts and for bone tissue engineering. The disclosure provides a hydrogels, cryogels and macroporous compositions modified with varying lengths of anionic pendant side chains (CH2?CHCONH(CH2)nCOOH, where n=1 to 12).Type: ApplicationFiled: July 13, 2012Publication date: January 17, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Shyni Varghese, Ameya Phadke
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Publication number: 20130012474Abstract: The invention relates to dispersible cellulose powder compositions comprising non-seed cellulose powder derived from algae, fungi or tunicates, which compositions are useful in a variety of products such as food products, pharmaceuticals, cosmetics, paints, biocompatible materials for artificial tissue engineering and implantable biomaterials and relates to methods for preparing non-seed cellulose powder compositions.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: FMC CORPORATIONInventors: Albert Mihranyan, Maria Strömme
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Publication number: 20130012535Abstract: It is intended to avoid dose dumping of a drug and improve the dissolution properties of the drug in the lower gastrointestinal tract, and thereby provide a sustained-release pellet preparation for oral administration that reliably exhibits its main pharmacological effect when orally administered once or twice a day. The present invention provides a sustained-release preparation obtained by mixing of (A) a pharmacologically active drug, (B) hydroxypropyl methylcellulose acetate succinate, (C) a plasticizer, and (D) polyethylene glycol followed by extrusion granulation.Type: ApplicationFiled: August 22, 2012Publication date: January 10, 2013Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Taro Kanamaru, Shinichiro Tajiri
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Publication number: 20130005643Abstract: The present invention relates to a method for preparing nano-particles, and more particularly, to a method for preparing nano-particles containing active materials in a simple and highly efficient manner through a grinding process.Type: ApplicationFiled: March 22, 2011Publication date: January 3, 2013Applicant: Bio-Synetics Inc.Inventors: Kab Sig Kim, Joo Won Park
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Publication number: 20130005831Abstract: The present disclosure provides rapidly dissolving oral capsules and films comprising pullulan, a plasticizer, and a dissolution enhancing agent.Type: ApplicationFiled: December 22, 2011Publication date: January 3, 2013Applicant: UNIVERSITY OF KANSASInventors: Roger A. Rajewski, Lian G. Rajewski, John L. Haslam
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Publication number: 20120328697Abstract: The present invention is directed to a solid dose form comprising a film coating composition encapsulating a core, wherein: (i) the core comprises an active ingredient comprising at least one of a pharmaceutical, veterinary, or nutraceutical active ingredient; (ii) the film coating composition comprises ethylcellulose and guar gum, wherein the guar gum has an apparent viscosity ?151.0 cps at a shear rate of 50 s?1 in a 1% aqueous guar gum solution measured rotationally at 20° C. after 1 minute equilibration using a 6 cm acrylic cone (1°) on a cone-plate viscometer wherein the shear is ramped up linearly from 1 to 50 s?1 in 25 steps over 29 seconds; (iii) the dose form provides controlled release of the active ingredient; (iv) the guar gum is present in an amount greater than 5 wt % based on the weight of the guar gum and ethylcellulose; and (v) the dose form is ethanol resistant.Type: ApplicationFiled: May 23, 2012Publication date: December 27, 2012Applicant: FMC CORPORATIONInventors: Juergen Siepmann, Yvonne Cuppok
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Publication number: 20120328679Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.Type: ApplicationFiled: September 7, 2012Publication date: December 27, 2012Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
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Publication number: 20120329884Abstract: Various ingredients and compositions are prepared from Stevia rebaudiana Bertoni plant. The compositions can be used as bulking agents, and sweeteners in foods, beverages, cosmetics and pharmaceuticals.Type: ApplicationFiled: June 22, 2012Publication date: December 27, 2012Applicant: PureCircle Sdn BhdInventor: Avetik MARKOSYAN
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Publication number: 20120316520Abstract: A transdermal therapeutic system for administering lipophilic, poorly water-soluble and/or sparingly skin-permeable pharmaceutical active substances. The active substance is present in a multi-component enhancer system consisting of 4 components and each component of the multi-component enhancer system is selected from a different one of the substance groups: a) terpenes, b) cyclic glucitol ethers, c) medium-chain triglycerides of capric and caprylic acid and/or of linoleic acid; and d) longer-chain alcohols having a chain length of 8 or more carbon atoms.Type: ApplicationFiled: August 22, 2012Publication date: December 13, 2012Applicant: LTS LOHMANN THERAPIE-SYSTEME AGInventors: Andreas Koch, Christoph Schmitz, Rolf Pracht, Mohammad Sameti
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Publication number: 20120309763Abstract: A pharmaceutical composition intended to be applied to a perforated nail is described. In particular, a composition is descirbed that includes an antifungal agent that is in the form of an acid salt, advantageously a hydrochloride; and a solvent system; and advantageously a cationic or positively charged amphoteric surfactant. The described composition can have a viscosity of less than 500 cPs.Type: ApplicationFiled: December 17, 2010Publication date: December 6, 2012Applicant: GALDERMA PHARMA S.A.Inventors: Claire Mallard, Nathalie Willcox
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Publication number: 20120301546Abstract: The present disclosure describes a delivery device for administration of nutraceuticals or pharmaceuticals, which device contains a soft gel shell comprising a gelatin-based water soluble film forming polymer, an acid insoluble polymer, and at least one reducing sugar and water, including processes, gel mixtures used for device production, and coatings containing such gel mixtures.Type: ApplicationFiled: May 26, 2011Publication date: November 29, 2012Inventor: Emadeldin M. Hassan
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Publication number: 20120301541Abstract: A compressed core for a pharmaceutical dosage form comprising a mixture of (a) at least one pharmaceutically acceptable organic acid, and (b) at least one pharmaceutically acceptable excipient is described. Such compressed core is useful for the preparation of pharmaceutical compositions containing a drug in which dissolution of the drug is favored in acidic environments. Also described are pharmaceutical compositions comprising such compressed core.Type: ApplicationFiled: May 24, 2012Publication date: November 29, 2012Inventors: Elina HARONSKY, Dafna Arieli
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Publication number: 20120295988Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.Type: ApplicationFiled: July 31, 2012Publication date: November 22, 2012Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
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Publication number: 20120294912Abstract: A cosmetic composition in the form of an O/W emulsion includes: (A) 1 to 20% by weight of a plate-like powder that has been surface-treated with an alkylalkoxysilane, (B) 0.1 to 10% by weight of an oil that is solid at a temperature of 25° C., (C) 0.3 to 50% by weight of an oil selected from the group consisting of a hydrocarbon oil, an ester oil, and an ether oil, each having a viscosity of 500,000 mPa·s or less at a temperature of 25° C., (D) 0.1 to 20% by weight of a nonionic surfactant having an HLB value of 8 or less, (E) 0.05 to 10% by weight of a water-soluble polymer having a hydrocarbon group with a carbon number of 8 to 30 and an anionic group in a molecule thereof, and (F) water.Type: ApplicationFiled: May 25, 2012Publication date: November 22, 2012Applicant: KAO CORPORATIONInventors: Takashi Fukui, Takashi Kawata
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Patent number: 8313754Abstract: Ophthalmic compositions suitable for use as artificial tears or as vehicles for ophthalmic drugs are disclosed. The compositions contain a combination of two polymers that have a synergistic effect on viscosity.Type: GrantFiled: April 11, 2011Date of Patent: November 20, 2012Assignee: Novartis AGInventors: Masood A. Chowhan, Huagang Chen
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Publication number: 20120288559Abstract: The present invention provides various pharmaceutical compositions comprising an S1P receptor modulator, e.g. an S1P receptor agonist. In one aspect, there is provided a pharmaceutical composition having a coating. In other aspects, rapid disintegrating compositions are provided. In a further aspect, a pharmaceutical composition which is free of sugar alcohols is provided. In another aspect, the invention provides a pharmaceutical composition comprising a coating comprising an S1P receptor modulator.Type: ApplicationFiled: July 19, 2012Publication date: November 15, 2012Inventors: Michael Ambühl, Jutta Beyer, Begona Carreno-Gomez, Colleen Ruegger, Stephen Valazza
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Publication number: 20120289559Abstract: Disclosed is a manufacturing method for a fine powder exhibiting improved solubility, little impurity contamination, and a high recovery rate. Material to be ground and a grinding medium are suspended and stirred in a liquefied inert gas dispersion medium such as dried ice, and the material to be ground is made into a sub-micron or nano-sized fine powder. A uniform fine powder can be obtained when the material to be ground is a mixture having two or more components. Impurity contamination can be reduced by using granular dry ice as the grinding medium.Type: ApplicationFiled: November 12, 2010Publication date: November 15, 2012Inventors: Toshiyuki Niwa, Shohei Sugimoto, Kazumi Danjo, Masaaki Nishio, Yasuo Nakanishi, Sakiko Kawamura
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Publication number: 20120288566Abstract: The present invention discloses liquid precursor compositions adapted for application on a hard surface in the oral cavity, comprising at least one therapeutic agent suitable for the treatment of oral disorders, at least one acidic-pH sensitive polymer, at least one hydrophobic polymer, and a pharmaceutically acceptable volatile carrier, wherein a weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1. The invention also discloses formulations formed of the solidification of these compositions, and methods for treating oral disorders by applying these compositions on hard surfaces in the oral cavity or to be placed in the oral cavity.Type: ApplicationFiled: October 5, 2010Publication date: November 15, 2012Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Michael Friedman, Doron Steinberg, Irith Gati
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Publication number: 20120288561Abstract: Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of an pharmaceutical composition comprising an analgesic agent.Type: ApplicationFiled: July 27, 2012Publication date: November 15, 2012Applicant: WELLESLEY PHARMACEUTICALS, LLCInventor: David A. Dill
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Publication number: 20120288562Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.Type: ApplicationFiled: September 14, 2010Publication date: November 15, 2012Inventors: Dominique Nicolas Cade, Xiongwei David He
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Patent number: 8309154Abstract: There is provided a surface-active material that comprises fibers which have been modified so as to impart surface-active properties onto said fibres and giving it a contact angle between 60° and 120°, wherein the fibres have an aspect ratio of more than 10 to 1,000. The surface-active material can be used for foam and emulsion formation and stabilization, coatings, encapsulation and drug delivery. It can for example be used in the following industries: foods, home and personal care, oilfield, agriculture, textile, construction, emulsion polymerization, leather, plastic, pulp, paper and pharma.Type: GrantFiled: November 22, 2006Date of Patent: November 13, 2012Assignee: Conopco, Inc.Inventors: Ya Cai, Jian Cao, Matthew Duncan Golding, Weichang Liu, Vesselin Nikolaev Paunov, Edward George Pelan, Simeon Dobrev Stoyanov, Weizheng Zhou
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Publication number: 20120277323Abstract: Disclosed are cellulose capsules, methods for preparing a cellulose capsule, and compositions comprising cellulose capsules, including sustained- or controlled-release dosage forms comprising cellulose capsules.Type: ApplicationFiled: November 8, 2010Publication date: November 1, 2012Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATIONInventors: Vijay Kumar, Bhavik Bhatt
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Publication number: 20120276185Abstract: The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.Type: ApplicationFiled: July 9, 2012Publication date: November 1, 2012Inventors: Syed F.A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
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Publication number: 20120277321Abstract: A method for preparing a composition including a compound based on vanillin and ethyl vanillin is described. A resulting composition and uses thereof in many fields of application, in particular in human and animal food is also described. A method for preparing a composition including a compound based on vanillin and ethylvanillin in a vanillin/ethyl vanillin molar ratio of 2 is also described wherein the method includes: a step of melting a mixture of vanillin and ethyl vanillin, which are used in a molar ratio other than 2, with an excess of vanillin representing from 2% to 20% of the weight of the mixture; a step of solidifying same, by cooling to a temperature of less than or equal to 50° C.±1° C.; and a step of recovering the resulting composition including the new compound.Type: ApplicationFiled: October 1, 2010Publication date: November 1, 2012Inventors: Jean-Claude Le-Thiesse, Kilani Lamiri
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Publication number: 20120269888Abstract: The invention is directed to a barrier composition, to a vehicle comprising said barrier composition, to a layer comprising said barrier composition, to a foodstuff comprising said vehicle or layer, to a pharmaceutical or nutraceutical composition comprising said vehicle or layer, to a method for protecting one or more active ingredients, and to the use of said barrier composition. The barrier composition of the invention comprises: a hydrophobic organic phase; and 0.1-75 vol. %, based on the total volume of the barrier composition, of biodegradable solid plate-like particles.Type: ApplicationFiled: October 20, 2010Publication date: October 25, 2012Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNOInventors: Jan Matthijs Jetten, Jacobus Eversdijk, Kjeld Jacobus Cornelis van Bommel, Johannes Wilhelmus Timmermans, Aafke Tessa ten Cate, Theodoor Maximiliaan Slaghek
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Publication number: 20120269908Abstract: The present invention relates to a carrier in oil-in-water emulsion form, containing a very small amount of a surface-active agent so that the emulsion is stable, well-tolerated, and nonirritating. The present invention also relates to a method for preparing a carrier according to the invention and to the use of such a carrier as a base for compositions to be applied onto sensitive human or animal body tissue, particularly in dermatological or dermocosmetic compositions.Type: ApplicationFiled: November 27, 2009Publication date: October 25, 2012Applicant: OCTALIA TECHNOLOGIESInventors: Christian Sarrazin, Marina Do, Michele Boix
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Publication number: 20120270955Abstract: An ophthalmic composition is disclosed having a viscosity enhancement system comprised of two different viscosity enhancing agents. The aqueous composition contains a first viscosity enhancing agent that provides enhanced viscosity upon dispensing of the composition to the eye and a second viscosity agent that increases viscosity (e.g., gels or partially gels) after dispensing of the composition to the eye to provide extended viscosity enhancement of the composition.Type: ApplicationFiled: April 19, 2012Publication date: October 25, 2012Inventors: Masood A. Chowhan, Malay Ghosh
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Publication number: 20120264833Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.Type: ApplicationFiled: June 26, 2012Publication date: October 18, 2012Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
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Publication number: 20120259022Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.Type: ApplicationFiled: June 19, 2012Publication date: October 11, 2012Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
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Publication number: 20120251622Abstract: A troche with 2.5-6% cellulose gum and at least 75% polyol molecules is disclosed. It may be an adherent troche, preferably adhered to teeth or gums or cheek with acacia gum. Consumers are instructed to use the troches to relieve the sensations of dry mouth, particularly while sleeping. The polyol molecules are preferably xylitol. The troches may be made with a bi-layer tablet press rounded on one side and flat on the other, preferably using acacia gum in the flat side layer for adhesion.Type: ApplicationFiled: May 22, 2012Publication date: October 4, 2012Inventor: Jeffrey T. Haley
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Publication number: 20120251588Abstract: Provided are a coating composition for delayed release preparation capable of releasing a drug promptly in the stomach, without causing a time-dependent change, after a time (lag time) in which a solid preparation does not release the drug; and a solid preparation obtained by coating of the coating composition. More specifically, provided are a coating composition comprising at least a nonionic water-soluble cellulose ether and a cellulose-based enteric base material, wherein a weight ratio of the nonionic water-soluble cellulose ether to the cellulose-based enteric base material is from 95:5 to 65:35; and a solid preparation comprising at least a drug-containing core and the coating composition which covers the core, wherein the preparation can permit prompt dissolution of the drug in a stomach after a lag time.Type: ApplicationFiled: March 9, 2012Publication date: October 4, 2012Inventors: Miyuki Fukasawa, Yuichi Nishiyama, Takafumi Hoshino
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Publication number: 20120245156Abstract: The present invention relates to a method for preparing an oral lyophilizate composition comprising: a) forming a liquid phase by using at least one homogenising agent having tensioactive properties, said liquid phase comprising at least an active pharmaceutical ingredient, a filler and/or a binding agent and a solvent, b) lyophilizing said liquid phase to form the oral lyophilizate composition.Type: ApplicationFiled: June 4, 2012Publication date: September 27, 2012Applicant: CEPHALON FRANCEInventor: Thanh-Tam Nguyen
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Publication number: 20120237575Abstract: A film coating agent for a solid formulation includes a water-soluble cellulose derivative, swelling clay, a cationic surfactant, and a fatty acid, wherein mass ratio of the swelling clay to the water-soluble cellulose derivative is 2:8 to 8:2, and content of the cationic surfactant is not less than 0.5 equivalents and not more than 3.0 equivalents relative to a cation exchange equivalent of the swelling clay.Type: ApplicationFiled: November 30, 2010Publication date: September 20, 2012Applicant: TORAY INDUSTRIES, INC.Inventors: Ryoji Yoshii, Yuki Hayashi, Yuki Fujisaki
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Publication number: 20120238644Abstract: Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel compositions are prepared by combining a polysaccharide component with a hydrophilic polymer and a cross-linking agent. Also provided are kits and systems for use in preparing the subject compositions.Type: ApplicationFiled: November 5, 2010Publication date: September 20, 2012Inventors: Glen Gong, Suresh Subraya Pai, Scott Robert Sershen
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Publication number: 20120231038Abstract: The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.Type: ApplicationFiled: November 14, 2011Publication date: September 13, 2012Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Morgana M. Trexler, Jenna L. Graham, Jennifer L. Breidenich, Jeffrey P. Maranchi, Julia B. Patrone, Marcia W. Patchan, Jennifer H. Elisseeff, Xiomara Calderon-Colon
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Publication number: 20120232167Abstract: Provided is a method of producing hydroxyalkylcellulose microparticles, the method including generating a pulse shock wave, and supplying a hydroxyalkylcellulose aqueous solution to the pulse shock wave generation region, thereby crushing and drying the hydroxyalkylcellulose aqueous solution. According to the production method, hydroxyalkylcellulose microparticles having a volume-average particle size of at least 0.1 ?m but less than 15 ?m are obtained. By mixing the hydroxyalkylcellulose microparticles with a principal agent and subjecting the resulting mixture to a tablet compression, a solid preparation having excellent tensile strength and disintegration properties can be obtained.Type: ApplicationFiled: November 24, 2010Publication date: September 13, 2012Applicants: Nippon Soda Co., Ltd.Inventors: Hirofumi Takeuchi, Satoru Abe, Takeshi Shimotori, Gentaro Nemoto
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Patent number: 8263124Abstract: The present invention relates to pharmaceutical compositions of antihistamine-decongestant combination. Specifically the invention relates to bilayered tablet formulation comprising antihistaminic decongestant combination. More specifically present invention relates to the novel polymorph of fexofenadine or pharmaceutically accepted salts thereof, with at least one decongestant in the form of bilayered tablet. The preferred polymorphs are polymorph A and polymorph X of fexofenadine hydrochloride.Type: GrantFiled: April 4, 2002Date of Patent: September 11, 2012Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.Inventors: Kamalakar Talasila, Debashis Dash, Srinivas Irukula, Dhanorkar Vipin Tatyasaheb, Mailatur Sivaraman Mohan
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Patent number: 8263047Abstract: A topical anesthetic for dental procedures is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the oral mucosa. The vehicle for transporting the tetracaine includes a water soluble mucoadhesive or a combination of mucoadhesives such as a high molecular weight poly(ethylene oxide) homopolymer and a cellulose polymer. The vehicle may additionally include a penetration enhancer such as propylene glycol. The tetracaine is ground into a powder and is suspended in a plasticized hydrocarbon gel which completes the vehicle.Type: GrantFiled: September 29, 2005Date of Patent: September 11, 2012Inventors: Alan J. Wickenhauser, Stephen E. Peipert
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Publication number: 20120225953Abstract: The present invention relates to self-emulsifying formulations based on an active ingredient component and a formulation base with a lipid component and with a binder component and to the use of this formulation as dosage form in the life science sector. The invention also describes a process for producing self-emulsifying formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as dosage form advantageously by use of melt extrusion. The formulations spontaneously form emulsions in water or aqueous media.Type: ApplicationFiled: April 18, 2012Publication date: September 6, 2012Applicant: ABBOTT GMBH & CO. KGInventors: Gunther Berndl, Jörg Breitenbach, Robert Heger, Michael Stadler, Peter Wilke, Jörg Rosenberg