Cellulose Or Derivative Patents (Class 514/781)
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Patent number: 8968783Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.Type: GrantFiled: May 24, 2011Date of Patent: March 3, 2015Assignee: Covidien LPInventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
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Publication number: 20150057356Abstract: A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26?0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.Type: ApplicationFiled: April 8, 2013Publication date: February 26, 2015Inventors: Nicholas S. Grasman, True L. Rogers, Oliver Petermann, Meinolf Brackhagen, Roland Adden
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Patent number: 8962697Abstract: The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.Type: GrantFiled: June 29, 2007Date of Patent: February 24, 2015Assignee: Interface Biologics Inc.Inventors: Frank Laronde, Hanje Chen
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Publication number: 20150050334Abstract: The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.Type: ApplicationFiled: August 27, 2014Publication date: February 19, 2015Inventors: Dominique Nicolas Cade, Xiongwei David He
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Patent number: 8957116Abstract: To provide a solution for forming a double eyelid which enables extremely easy formation of a natural and ideal double eyelid without giving a displeased feeling or an uncomfortable feeling to a user, and a method for forming a double eyelid using the solution for forming a double eyelid. A solution for forming a double eyelid 1 according to the present invention is formed by dissolving, into a solvent having volatility, a fibrous material which forms a film 1a onto a skin 5a of an eyelid 5 and shrinks with vaporization of the solvent. By applying the solution 1, in a successive-curve form, over an imaginary line I forming a fold 5d of a double eyelid in the eyelid 5 onto which a user want to make a fold and vaporizing the solvent so as to shrink the film 1a, successive concaved groove-like constricted part 5c is formed on the imaginary line I and the fold 5d of a double eyelid along the constricted part 5c is formed.Type: GrantFiled: January 27, 2010Date of Patent: February 17, 2015Inventors: Naoko Iwagaki, Masayuki Kamagata, Jirou Taniyama
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Publication number: 20150045452Abstract: The present application provides an orally-disintegrating tablet having excellent tablet hardness and disintegrability. The present application further provides a method of producing a disintegrative particulate composition including three components consisting of a first disintegrator component of an acid-type carboxymethylcellulose, a second disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using granules obtained in the first wet granulation step and the remaining one component of the three components not used in the first wet granulation step. The production method may further includes a crystalline cellulose as a fourth component or a third step of mixing a crystalline cellulose into granules obtained in the second wet granulation step. Disintegrative particulate compositions obtained by these methods are also disclosed.Type: ApplicationFiled: March 27, 2013Publication date: February 12, 2015Inventors: Takahiro Hiramura, Kiyoshi Ikura, Sae Itaya, Tomohito Okabayashi, Naohiro Hashikawa, Tetsuro Morita, Kimko Ikeda, Haruka Wakayama
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Patent number: 8952057Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.Type: GrantFiled: June 16, 2011Date of Patent: February 10, 2015Assignee: JR Chem, LLCInventor: José E. Ramirez
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Patent number: 8940800Abstract: Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and hydroxypropyl methyl cellulose acetate (HPMCA) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility drug and such polymers, the polymers provide enhanced aqueous concentrations and/or improved physical stability.Type: GrantFiled: June 26, 2012Date of Patent: January 27, 2015Assignee: Bend Research, Inc.Inventors: Walter C. Babcock, Dwayne T. Friesen, David Keith Lyon, Warren Kenyon Miller, Daniel Tod Smithey
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Publication number: 20150024054Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.Type: ApplicationFiled: August 6, 2014Publication date: January 22, 2015Applicant: BEND RESEARCH, INC.Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
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Patent number: 8936795Abstract: A liquid embolic material may include a mixture of a first solution comprising between about 1.2% and about 2.5% weight per volume (w/v) carboxymethyl chitosan (CCN) in a first solvent and a second solution comprising between about 1.2% and about 2.5% w/v oxidized carboxymethyl cellulose (OCMC) in a second solvent. The liquid embolic material may be used to embolize a targeted embolization location by mixing the first solution and the second solution to form a liquid embolic material (or hydrogel precursor material), introducing the hydrogel precursor material to a targeted embolization location within a body of a patient, and allowing the CCN and the OCMC to react to form the hydrogel material and embolize the targeted embolization location.Type: GrantFiled: December 19, 2012Date of Patent: January 20, 2015Assignee: Regents of the University of MinnesotaInventors: Jafar Golzarian, Lihui Weng
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Patent number: 8932563Abstract: Described herein are polymer matrix films, compositions comprising the polymer matrix films, and methods of preparing and using the same.Type: GrantFiled: May 26, 2010Date of Patent: January 13, 2015Assignee: Colgate-Palmolive CompanyInventors: Melissa Martinetti, Thomas Boyd, James R. Brown, Betty Won, Shira Pilch, James Gerard Masters, Paloma Pimenta
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Patent number: 8932612Abstract: The present invention relates to a composition for cosmetic raw material containing cellulose dyed with a natural coloring matter having improved photostability, and a visual carrier system comprising the same. In the composition for cosmetic raw material and the visual carrier system comprising the same according to the present invention, by using no iron oxide chemical coloring matter and applying a typical and natural dyeing method of cloths to the microcrystalline cellulose that is the cosmetic raw material, photostability that is a problem of the natural coloring matter in the related art is largely improved.Type: GrantFiled: October 17, 2008Date of Patent: January 13, 2015Assignee: KPT Ltd.Inventors: Byung-Ho Park, Ik-Joo Lee, Mi-Hyun Jang, Jae-Uk Lee
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Patent number: 8927609Abstract: The present invention is directed to a co-attrited stabilizer composition comprising: (i) microcrystalline cellulose and (ii) carboxymethyl cellulose, wherein the carboxymethyl cellulose has a degree of substitution of from 0.95-1.5 and a viscosity of less than 100 cps. The composition is useful as a stabilizer, particularly, in food and pharmaceutical applications.Type: GrantFiled: November 30, 2012Date of Patent: January 6, 2015Assignee: FMC CorporationInventors: Zheng Tan, Aaron Chip Venables, Michael Sestrick, Nadia Yaranossian, Jeremy Ondov
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Publication number: 20150004237Abstract: Provided are cellulose esters useful for inhibiting solution crystallization of drugs. Specific polymers include cellulose esters of formula I: wherein n of the ?-carboxyalkanoyl group, is 3, 4, 6, or 8 to provide a ?-carboxyalkanoyl group chosen from succinoyl, glutaroyl, adipoyl, sebacyl, and suberyl groups; and wherein R is chosen from: a hydrogen atom; and an alkanoyl group chosen from acetyl, propionyl, butyryl, valeroyl, hexanoyl, nonanoyl, decanoyl, lauroyl, palmitoyl, and stearoyl groups; wherein there is a total degree of substitution of the alkanoyl group and the ?-carboxyalkanoyl group of at least 2.0; and wherein the polymer comprises m repeating units where n=1 to 1,000,000, or 10 to 100,000, or 100 to 1,000, such as 1 to 6,000. Embodiments further include compositions comprising cellulose esters and poorly water-soluble drugs, which compositions exhibit greater solubility and stability in solution as compared to the drugs alone.Type: ApplicationFiled: January 9, 2013Publication date: January 1, 2015Inventors: Kevin J. Edgar, Bin Li, Lynne Taylor, Grace Ilevbare, Stephanie M. Williams, Haoyu Liu
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Publication number: 20140369997Abstract: The present application describes a method of creating a foaming ophthalmic formulation. The described formulation includes the addition of a foaming agent. The resulting solution is designed to be distributed by a non-aerosol foaming bottle/or aerosol.Type: ApplicationFiled: February 2, 2012Publication date: December 18, 2014Applicant: PASEInventor: Calvin Alexander Grant
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Publication number: 20140370180Abstract: The subject matter of this invention is a composition and method of making a water-dispersible, stabilizing colloidal microcrystalline cellulose:xarboxymethylcellulose composition. The method of making the composition does not require a salt solution as an anti-slip agent.Type: ApplicationFiled: October 4, 2012Publication date: December 18, 2014Applicant: FMC CORPORATIONInventors: Zheng Tan, Maurice Gerard Lynch, Michael Sestrick, Nadia Yaranossian
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Patent number: 8906403Abstract: A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inclusion complex(es) and/or cyclodextrin derivative inclusion complex(es), at least one poly(carboxylic) acid, and optionally a catalyst; b) heating at a temperature between 100° C. and 200° C. for a period of 1 to 60 minutes; c) washing with water; d) drying, wherein at least one bioactive agent is incorporated in the biomaterial by impregnation of the biomaterial after the drying step in a concentrated solution of the bioactive agent.Type: GrantFiled: November 15, 2005Date of Patent: December 9, 2014Assignees: Universite des Sciences et Technologies de Lille SAIC, Universite de Droit et SanteInventors: Bernard Martel, Nicolas Blanchemain, François Boschin, Stephan Haulon, Elisabeth Delcourt Debruyne, Michel Morcellet, Hartmut Friederich Hildebrand
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Publication number: 20140356427Abstract: An orally disintegrating tablet is obtained by dry tabletting a mixture of: hydroxyalkyl cellulose microparticles having a 50% particle size in the cumulative particle size distribution of more than or equal to 15 ?m and less than 40 ?m, and having a hydroxyalkyl group content of 40 to 80% by mass; a main drug as a pharmaceutical ingredient; and optionally, additives such as an excipient, a binder, a disintegrant, a lubricating agent, an agent for sustained release, a base material, a coloring agent, a pH adjusting agent, a pH buffer agent, a surfactant, a stabilizer, an acidulant, a flavoring agent, a fluidizing agent, a refreshing agent, a sweetener, a savoring component, and a sweetness intensifier.Type: ApplicationFiled: September 21, 2012Publication date: December 4, 2014Inventors: Shinichiro Tsue, Takeshi Shimotori, Takashi Kato
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Publication number: 20140350526Abstract: A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments may include one or more therapeutic substances for locally reducing pain, facilitating healing and/or otherwise treating mucosal tissue at or near a tonsil bed.Type: ApplicationFiled: June 18, 2014Publication date: November 27, 2014Inventors: Joshua Makower, John Y. Chang, Ketan P. Muni, Wenda Carlyle, Howard Levine, William M. Facteau
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Publication number: 20140335035Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a particulate benefit agent.Type: ApplicationFiled: May 8, 2014Publication date: November 13, 2014Applicant: The Procter & Gamble CompanyInventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray WHITELY, Sherrie Ann JORDAN
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Publication number: 20140335034Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a preservative.Type: ApplicationFiled: May 8, 2014Publication date: November 13, 2014Applicant: The Procter & Gamble CompanyInventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
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Publication number: 20140335033Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a perfume.Type: ApplicationFiled: May 8, 2014Publication date: November 13, 2014Applicant: The Procter & Gamble CompanyInventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
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Publication number: 20140335032Abstract: A consumer product comprises silane-modified oil comprising a hydrocarbon chain selected from the group consisting of: a saturated oil, an unsaturated oil, and mixtures thereof; and at least one hydrolysable silyl group covalently bonded to the hydrocarbon chain. The consumer product further comprises a hydroxyl functional organic species and is substantially free of silica particles.Type: ApplicationFiled: May 8, 2014Publication date: November 13, 2014Applicant: The Procter & Gamble CompanyInventors: Rajan Keshav PANANDIKER, Beth Ann SCHUBERT, John August WOS, Luke Andrew ZANNONI, Nathan Ray Whitely
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Patent number: 8883221Abstract: Micronutrient combination product, wherein the micronutrient combination product comprises zeaxanthin, lutein, zinc and copper.Type: GrantFiled: December 17, 2004Date of Patent: November 11, 2014Assignee: Bausch & Lomb IncorporatedInventors: Guenter Bellmann, Gudrun Claus-Herz
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Patent number: 8883176Abstract: The invention describes a coating composition comprising an effective amount of a water-soluble cellulose ether, a poly(N-vinyl pyrrolidone-co-vinyl acetate) copolymer, a film-forming agent based on D-glucose, and a plasticizer.Type: GrantFiled: September 24, 2009Date of Patent: November 11, 2014Assignee: ISP Investments Inc.Inventors: Lana L. Terzian, Stuart C. Porter
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Publication number: 20140322325Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.Type: ApplicationFiled: July 14, 2014Publication date: October 30, 2014Applicant: Bend Research, Inc.Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
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Publication number: 20140322282Abstract: Ultra-fine microcrystalline cellulose compositions are disclosed which comprise co-attrited microcrystalline cellulose and a hydrocolloid. The compositions have a mean particle size of less than 10 microns. The compositions are prepared by subjecting a high solids mixture of microcrystalline cellulose and a hydrocolloid to high shear forces in the presence of an anti slip agent preferably an aqueoussolution of an inorganic salt. The compositions are especially useful in food, pharmaceutical and cosmetic and industrial applications.Type: ApplicationFiled: July 10, 2014Publication date: October 30, 2014Inventors: Domingo C. Tuason, Jose Amundarain, Gregory R. Krawczyk, Edward Selinger, William R. Blakemore, James J. Modliszewski, Joseph Lee, Frank Messick
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Patent number: 8865778Abstract: A controlled release excipient composition suitable in formulation of a slow or extended release tablet, contains a synergistic mixture of substantially uncross-linked carboxymethyl starch, or sodium starch glycolate (SSG), and a hydrophilic, non-ionic cellulose ether, preferably hydroxypropylmethylcellulose. Whether or not a SSG in the mixture is sufficiently uncross-linked in the context of the invention can be determined by sedimentation: 0.25 g of the formulation in 100 ml deionized water after 24 hours at 25° C., if subjected to centrifugation at 6080 G at 25° C. for 15 minutes, should exhibit a sedimentation volume of more than 60 ml.Type: GrantFiled: December 4, 2007Date of Patent: October 21, 2014Assignee: Campina Nederland Holding B.V.Inventors: Linqiu Cao, John Richard Langridge, Alexander Wilhelmus Van Gessel
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Publication number: 20140309315Abstract: Compositions comprising carboxypolysaccharides (CPS) including carboxymethyl cellulose (CMC) and polyethylene glycols (PEGs) are provided where the PEG is a PEG-epoxide covalently linked to the CPS. In certain embodiments, the PEG attaches to only one CPS, forming a decorated CPS. In other embodiments, bi-functional PEG molecules are attached to adjacent CPSs, thereby forming a covalently cross-linked composition. Additional embodiments include PEG/CMC compositions where the PEG is a multi-branch PEG and/or a multi-arm PEG. PEG/CMC compositions can be made with desired viscoelastic properties, and such compositions can be used as space-filling materials, load-bearing materials, anti-adhesion compositions, drug delivery vehicles or lubrication of tissues and medical instruments.Type: ApplicationFiled: June 24, 2014Publication date: October 16, 2014Inventors: Samuel J. Falcone, Richard A. Berg
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Publication number: 20140308356Abstract: A granular material which has a mean particle diameter of 150 to 800 micrometers; and an unsettled bulk density of 0.1 to 0.35 g/cm3 and/or a compactibility which results in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa; and wherein the main component of the granular material is a cellulose derivative or an alkylene oxide homo- or copolymer or a blend thereof is useful for preparing dosage forms with a controlled release profile.Type: ApplicationFiled: June 27, 2014Publication date: October 16, 2014Applicants: THE DOW CHEMICAL COMPANY, DCOMCO, INC.Inventors: Tim D. Cabelka, Akshay Bellare, Ka Chun A. Chan, Tina P. Dasbach, Kacee B. Ender, Karl V. Jacob, Robert E. Scheid, JR.
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Publication number: 20140303264Abstract: The present invention is directed to a process comprising: (i) extracting ?50% by weight of all carrageenan from a carrageenan-containing seaweed material to obtain a cellulose-containing seaweed residue; and (ii) purifying the cellulose-containing seaweed residue by at least one of hydrolysis or bleaching. The present invention is also directed to the cellulose obtained from the process, as well as products containing the cellulose-containing seaweed material.Type: ApplicationFiled: August 31, 2012Publication date: October 9, 2014Applicant: FMC CORPORATIONInventors: Zheng Tan, Michael Sestrick, William Matakas, Aaron Chip Venables
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Publication number: 20140287061Abstract: A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.Type: ApplicationFiled: November 12, 2012Publication date: September 25, 2014Applicant: Suneris, Inc.Inventor: Joseph A. Landolina
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Publication number: 20140287014Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.Type: ApplicationFiled: January 20, 2014Publication date: September 25, 2014Inventors: Timothy A. Ringeisen, William Christopher Wattengel
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Publication number: 20140275287Abstract: The present invention relates to water soluble and completely absorbable and/or physiologically degradable hemostatic compositions having a wax or wax-like base effective for use in tamponade hemostasis of bone or cartilage.Type: ApplicationFiled: November 1, 2012Publication date: September 18, 2014Applicant: ABYRX, INC.Inventors: David Knaack, John Pacifico, Marci Wirtz, Richard L. Kronenthal, Frank Do, Aniq Darr
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Publication number: 20140271521Abstract: A process for forming a personal care article, the process including (a) producing an extrudate from a twin screw extruder, and (b) forming the extrudate into the personal care article. The personal care article includes (i) from about 10% to about 60% of one or more anionic surfactants, wherein the one or more anionic surfactants have a Krafft point of less than 30° C.; (ii) from about 10% to about 50% of one or more water soluble polymers; (iii) from about 1% to about 30% of one or more plasticizers; and (iv) from about 10% to about 50% water.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: The Procter & Gamble CompanyInventors: Robert Wayne GLENN, JR., Todd Ryan THOMPSON, Ungyeong JUNG, Changwei ZHU, Alireza TABATABAEI-NAEINI
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Publication number: 20140271787Abstract: Disclosed herein is a soft, flexible, continuous, single-layer structural directional active delivery device such as a film product with discrete domains useful for controlled administration of the active to a patient. The discrete domains are substantially inseparable from one another, have different rates of dissolution and advantageously offer superior adhesion to the body of the patient while administering the active directionally and effectively.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: MONOSOL RX, LLCInventor: MONOSOL RX, LLC
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Patent number: 8835376Abstract: A process for making particles for delivery of drug nanoparticles is disclosed herein. The process comprises the steps of (a) forming a suspension of drug nanoparticles by mixing a precipitant solution with an anti-solvent solution under micro-mixing environment, where the formed nanoparticles have a narrow particle size distribution; (b) providing an excipient to at least one of the precipitant solution, the anti-solvent solution and the suspension of drug nanoparticles, the excipient being selected to maintain said drug nanoparticles in a dispersed state when in liquid form; and (c) drying the suspension of drug nanoparticles containing the excipient therein to remove solvent therefrom, wherein removal of the solvent causes the excipient to solidify and thereby form micro-sized matrix particles, each micro-sized particle being comprised of drug nanoparticles dispersed in a solid matrix of the excipient.Type: GrantFiled: September 24, 2009Date of Patent: September 16, 2014Assignee: Nanomaterials Technology Pte LtdInventors: Zhigang Shen, Jimmy Sung Lai Yun, Jun Hu, Nital Arvind Jugade, Jiyao Zhang, Wenhao Chen, Zhe Wang, Lingyan Gao, William Glover, Jian Feng Chen
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Publication number: 20140256832Abstract: The disclosure relates to a fullerene-derived cellulose nanocrystals, process for preparing same and methods of using said nanocrystals.Type: ApplicationFiled: March 6, 2014Publication date: September 11, 2014Applicant: CELLUFORCE INC.Inventors: Zhaoling Yao, Janelle Huimin Tam
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Patent number: 8828438Abstract: A solid amorphous dispersion comprises a cholesteryl ester transfer protein (CETP) inhibitor, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase inhibitor), and a concentration enhancing polymer. At least a major portion of the CETP inhibitor in the dispersion is amorphous. The solid amorphous dispersion provides concentration-enhancement of the CETP inhibitor when administered to an aqueous use environment.Type: GrantFiled: May 22, 2006Date of Patent: September 9, 2014Assignee: Bend Research, Inc.Inventors: Dwayne Thomas Friesen, Bruno Caspar Hancock, Rodney James Ketner, David Keith Lyon, James Alan Shriver Nightingale, Ravi Mysore Shanker
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Publication number: 20140248223Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. Desirably, the films contain at least one active agent, which may be administered to a user topically, transmucosally, vaginally, ocularly, aurally, nasally, transdermally or orally.Type: ApplicationFiled: March 3, 2014Publication date: September 4, 2014Applicant: MONOSOL RX, LLCInventors: Garry L. Myers, Richard C. Fuisz
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Publication number: 20140249235Abstract: The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position.Type: ApplicationFiled: February 21, 2014Publication date: September 4, 2014Applicant: HERCULES INCORPORATEDInventors: Todd A. Brugel, Tuyen T. Nguyen, Sangrama Sahoo, Divya Tewari, Yuda Zong
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Patent number: 8821936Abstract: This invention provides a solid pharmaceutical formulation having high physical strength and further having excellent drug release properties and digestibility of excipients when administered, which comprises (a) an active medical ingredient and (b) a pre-gelatinized starch in an amount of 10 to 90% by weight, said pre-gelatinized starch being prepared by pre-gelatinizing a cheap and stable usual starch during the procedure for formulation. This invention also provides a method for preparing the solid pharmaceutical formulation.Type: GrantFiled: May 19, 2005Date of Patent: September 2, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventor: Tadashi Mukai
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Publication number: 20140242024Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.Type: ApplicationFiled: May 8, 2014Publication date: August 28, 2014Applicant: Covidien LPInventors: Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla, Timothy Sargeant, Joshua Stopek
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Publication number: 20140227357Abstract: The present disclosure relates to fill formulations comprising at least one polymer and at least one fill component wherein the at least one fill component in the absence of the at least one polymer will migrate into or through a capsule shell. The present disclosure also relates to capsules comprising fill formulations according to the present disclosure. The present disclosure also relates to methods of reducing migration of fill components into or through the shell resulting in increased product integrity.Type: ApplicationFiled: September 13, 2012Publication date: August 14, 2014Applicant: CAPSUGEL BELGIUM NVInventors: Jan Vertommen, David Delmarre, Marie Sophie Martina
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Patent number: 8796341Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.Type: GrantFiled: June 11, 2013Date of Patent: August 5, 2014Assignee: Bend Research, Inc.Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
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Patent number: 8790695Abstract: A medicinal carrier is provided. The medicinal carrier comprises a first component, which is a biocompatible polymer with an amino group (—NH2); a saccharide; and a second component which is a biocompatible material. The saccharide grafts to the first component via the amino group (—NH2) of the first component, and the first component bonds to the second component via an ionic bond. The medicinal carrier can protect the medicine from gastric acid and swell or decompose to release the medicine under a specific pH condition, thus, showing a good applicability.Type: GrantFiled: November 27, 2012Date of Patent: July 29, 2014Assignee: China Medical UniversityInventor: Yu-Hsin Lin
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Patent number: 8771650Abstract: This invention relates to inducible release vehicle comprised of crosslinked carbohydrates or proteins and an active ingredient. The release is induced by an external stimulus, e.g. an enzyme such as amylase. Such a vehicle can particularly be used in an applications for preventing microbial decay or combating microbial infections. Other uses are for oral applications such as providing anti-caries or flavoring compounds and for pharmaceutical and/or nutraceutical applications.Type: GrantFiled: October 7, 2011Date of Patent: July 8, 2014Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNOInventors: Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn, Johannes Wilhelmus Timmermans, Theodoor Maximiliaan Slaghek, Jacobus Johannes Frederik van Veen, Johannes Wilhelmus Leonardus Boumans
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Patent number: 8771649Abstract: This invention relates to inducible release vehicle comprised of crosslinked carbohydrates or proteins and an active ingredient. The release is induced by an external stimulus, e.g. an enzyme such as amylase. Such a vehicle can particularly be used in applications for preventing microbial decay or combating microbial infections. Other uses are for oral applications such as providing antdaries or flavoring compounds and for pharmaceutical and/or nutraceutical applications.Type: GrantFiled: May 28, 2004Date of Patent: July 8, 2014Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek TNOInventors: Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn, Johannes Wilhelmus Timmermans, Theodoor Maximiliaan Slaghek, Jacobus Johannes Frederick van Veen, Johannes Wilhelmus Leonardus Boumans
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Publication number: 20140186427Abstract: The present invention pertains to oral applicable therapeutic dosage forms, in particular to orodispersible films. The present invention especially is directed to orodispersible films comprising a base layer substantially free of therapeutically active agents and a top layer comprising the desired therapeutically active agents. The present invention also concerns suitable base layers for such orodispersible films as well as therapeutical uses thereof and methods for manufacturing them.Type: ApplicationFiled: August 13, 2012Publication date: July 3, 2014Applicant: TESA LABTEC GMBHInventors: Armin Breitenbach, Sebastian Braun, Ralf Schliephacke
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Publication number: 20140170097Abstract: The invention provides compositions and methods for reversible covalent binding of benefit agents to keratinous substrates through the reaction of a dicarbonyl functional group on the surface of a benefit agent with reactive amines on keratinous surfaces. The deposits formed are durable and resistant to transfer, but are readily removed by contacting the deposit with an amine-containing solution.Type: ApplicationFiled: December 18, 2012Publication date: June 19, 2014Applicant: AVON PRODUCTS, INC.Inventors: Sung Bin Shin, Sen Yang