Cement Or Filling Composition Patents (Class 523/116)
  • Publication number: 20140135418
    Abstract: The subject matter of the invention is a curable composition for use as bone cement, in particular for augmentation of osteoporotic bone tissue, comprising at least one organic polymer and at least one monomer for radical polymerisation, at least one particulate inorganic additive having a BET surface of at least 40 m2/g, whereby the additive comprises covalently bound hydroxyl groups, whereby the composition further comprises at least one fatty acid ester or a mixture of fatty acid esters. Another subject matter of the invention is the use of said composition for augmentation of osteoporotic bone tissue and particularly preferably for vertebroplasty, kyphoplasty, and augmentation of drill holes in osteoporotic bone tissue, as well as a kit for producing said composition.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 15, 2014
    Inventor: Sebastian VOGT
  • Patent number: 8722759
    Abstract: Fillers containing silica-zirconia nanoclusters are disclosed. The fillers may be prepared by mixing a sol of silica nanoparticles with a sol of preformed, crystalline nanozirconia particles. The fillers provide desirable optical properties, such as opalescence, and are useful in dental compositions.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: May 13, 2014
    Assignee: 3M Innovative Properties Company
    Inventor: Bradley D. Craig
  • Publication number: 20140121280
    Abstract: A dental composition comprising: a) about 1 to about 80% by weight of particulate material including: (i) calcium silicate, calcium aluminate, tetracalcium aluminoferrite, calcium phosphate, calcium sulfate, silica, alumina, calcium oxide, calcium hydroxide, or mixtures thereof; and b) about 1 to about 50% by weight liquid carrier including: (i) water-soluble polymer, (ii) surfactant, the surfactant is selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and sarcosinates, and mixtures thereof; and (iii) water; wherein the particulate and liquid carrier being mixed together to form a hydrate gel material that can harden.
    Type: Application
    Filed: January 7, 2014
    Publication date: May 1, 2014
    Applicant: DENTSPLY International Inc.
    Inventors: Carolyn M. Primus, James L. Gutmann, Miklos M. Breuer, Steven R. Jefferies
  • Patent number: 8710114
    Abstract: The present application provides dental fillers, and methods of making and using dental fillers that include a treated surface that includes phosphorus and a divalent cation. Dental compositions including such dental fillers can be useful for delivering ions to the oral environment.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: April 29, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Richard P. Rusin, Sumita B. Mitra, Kevin M. Cummings
  • Patent number: 8710115
    Abstract: The invention relates to a composition comprising an ethylenically unsaturated acidic compound, water, a functionalized silane, an initiator, optionally comprising a sensitising agent, a non-surface treated filler, optionally a solvent, optionally an ethylenically unsaturated compound, optionally additives selected from the group consisting of stabilizer(s), photobleachable colorant(s), fluoride release agent(s), pigments. The invention also relates to a process of producing such a composition by in-situ silanization of the non-surface treated filler.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: April 29, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Christoph Thalacker, Andreas A. Heumann
  • Patent number: 8703840
    Abstract: The present invention provides a dental adhesive material kit having excellent bond durability. The present invention is represented by a dental adhesive material kit containing a dental aqueous adhesive composition (A) and a multi-part type dental nonaqueous curable composition (B). The dental aqueous adhesive composition (A) contains a polymerizable monomer (a) having an acidic group, an aliphatic polymerizable monomer (b) having no acidic group, water (c), and an amine-based reducing agent (d1) containing no sulfur atom. The multi-part type dental nonaqueous curable composition (B) contains an aliphatic polymerizable monomer (b) having no acidic group, an aromatic polymerizable monomer (e) having no acidic group, a powdery water-soluble reducing compound (f) containing a sulfur atom, an organic peroxide (g), and an amine-based reducing agent (d2) containing no sulfur atom.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: April 22, 2014
    Assignee: Kuraray Noritake Dental Inc.
    Inventors: Michiya Kawana, Hidemi Nakayama, Mitsuru Takei, Kenji Suzuki, Ai Hinamoto
  • Patent number: 8697772
    Abstract: Certain novel polymerizable phosphoric acid derivatives (hereinafter referred to as monomers) comprising a polyalicyclic structure element, mixtures comprising one or a plurality of these compounds and corresponding curable blends and products as well as their respective use as a dental material or for the preparation of a dental material are described. The compounds are eminently suitable as bonding agents, in particular in dental adhesive materials. A process for preparing these compounds or mixtures and a method for preparing a product, preferably a product suitable for dentistry, are also described.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: April 15, 2014
    Assignee: VOCO GmbH
    Inventors: Tobias Blömker, Manfred Stepputtis, Manfred Thomas Plaumann
  • Publication number: 20140100297
    Abstract: A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.
    Type: Application
    Filed: December 10, 2013
    Publication date: April 10, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventors: Elliott Gruskin, Andreas Boger, Andrea Montali, Kurtis Wheeler
  • Patent number: 8691886
    Abstract: To provide a dental hydraulic temporary sealing material composition setting faster than conventional composition, excellent adhesiveness with cavity, and extremely good operativity of filling in an oral cavity, the dental hydraulic temporary sealing material composition includes calcium sulfate, a vinyl acetate resin, an inorganic filler, alcohols having a boiling point of 110° C. or more, and a nonionic surfactant, whereby water on a cavity can adhere, without being repelled, to a paste surface due to hydrophilic effect between an organic solvent having proper hydrophilicity and the nonionic surfactant, the water can permeate and diffuse rapidly and stably through the inside of the paste by the hydrophilic effect so as to set faster than conventional composition, and since the hydrophilic effect is effective for adhesiveness with cavity, filling property in an oral cavity becomes extremely good.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: April 8, 2014
    Assignee: GC Corporation
    Inventors: Yutaka Shinozaki, Shouichi Fukushima, Hiroshi Kamohara
  • Patent number: 8686064
    Abstract: The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a biocompatible polymeric matrix. The resulting composites may be used as such or be further processed to form an osteoimplant.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: April 1, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Lawrence A. Shimp, David Knaack
  • Patent number: 8686063
    Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: April 1, 2014
    Assignee: Charité—Universitätsmedizin Berlin
    Inventors: Hendrik Meyer-Lückel, Sebastian Paris, Andrej M. Kielbassa
  • Patent number: 8669302
    Abstract: The application of certain (preferably photocurable) composite materials comprising a monomer with a polyalicyclic structure element as a dental sealing material is described herein. A description is also provided of novel polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a composite material to be applied and their application in a composite material.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: March 11, 2014
    Assignee: VOCO GmbH
    Inventors: Tobias Blömker, Manfred Stepputtis, Manfred Thomas Plaumann, Reinhard Maletz
  • Patent number: 8664294
    Abstract: A self etching, dental cement composition is provided having the advantage of not requiring a separate etching and bonding step. The cement composition comprises a polymerizable (meth)acrylate trimellitic acid/anhydride, a phosphoric acid (meth)acrylate, a hydroxyalkyl(meth)acrylate, copolymerizable multi-functional (meth)acrylate monomers, a diluent, fillers, and a curing system. These cement compositions are prepared as a two-paste system that is combined prior to use.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: March 4, 2014
    Assignee: Pentron Clinical Technologies, LLC
    Inventors: Weitao Jia, Shuhua Jin
  • Publication number: 20140053758
    Abstract: The present invention relates to restorative materials, in particular to glass-ionomer cements. More particularly, the present invention relates to glass-ionomer cements having particular utility in the repair of human hard tissue, in particular as dental restorative materials and in orthopaedic surgery. We describe a composition comprising a mixture of a glass ionomer cement and zinc phosphate. Preferably, the composition comprise from 40 to 95% by weight of glass ionomer cement and from to 60% by weight of zinc phosphate. The present invention also provides a powdered composition comprising a fluorosilicate glass and deactivated zinc oxide. Such that the zinc phosphate is formed in sith by reaction between the zinc oxide and phosphoric acid.
    Type: Application
    Filed: January 24, 2012
    Publication date: February 27, 2014
    Applicant: University of Greenwich
    Inventors: John Nicholson, Samantha Booth
  • Patent number: 8658713
    Abstract: A bone cement composition which contains titanium dioxide particles having a median diameter of 0.5 to 7.0 ?m as measured by a laser diffraction/scattering particle size distribution analyzer and a BET specific surface area of 0.5 to 7.0 m2/g as measured by a nitrogen adsorption method, and a base-forming component comprising a (meth)acrylate polymer and a (meth)acrylate monomer, wherein the content of the titanium dioxide particles is 5 to 50% by mass based on the total mass of the composition. The bone cement composition has bioactivity and is capable of forming a hardened material having a high mechanical strength.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: February 25, 2014
    Assignees: Kyoto University, Ishihara Sangyo Kaisha, Ltd.
    Inventors: Takashi Nakamura, Koji Goto, Takehiro Shibuya, Yoshimichi Ueda, Tokuo Suita, Hiroaki Nishii
  • Patent number: 8658712
    Abstract: Improved compositions comprising a mixture of particulate materials with water-based liquids containing water-soluble polymers and surfactants are provided. Examples of particulate powders include mixtures of calcium silicate, calcium aluminate, calcium sulfate, and hydroxyapatite. Examples of water-soluble polymers include polyvinyl alcohols, polyvinyl pyrrolidone, partially hydrolyzed polyvinyl acetates, polyacrylic acid, and polymethacrylic acid. Surfactants such as sodium dodecyl sulfate are added to the composition to interact with the polymeric materials. The compositions are particularly suitable for sealing and obturating dental root canals and root apices. The composition provides a stable barrier to bacterial and fluid leakage in the root canal system of a tooth. In addition, the compositions help promote the growth of new bone and tissue surrounding the root-tip area or dentin tissue that covers an injured or amputated pulp.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: February 25, 2014
    Assignee: Dentsply International Inc.
    Inventors: Carolyn M. Primus, James L. Gutmann, Miklos M. Breuer, Steven R. Jefferies
  • Publication number: 20140051782
    Abstract: A process for producing a particulate dental filler in which a dental particulate inorganic material is admixed with a curable organic monomeric material containing acrylate groups to produce a suspension in a liquid. The suspension is spray dried to produce an atomized powder and the monomeric material is cured.
    Type: Application
    Filed: August 16, 2012
    Publication date: February 20, 2014
    Inventors: Joshua James Cheetham, Wilson Ta, Paul James Farrar
  • Patent number: 8647614
    Abstract: A method for reducing the occurrence of new post-operative fractures in vertebrae of a patient's spine after a vertebroplasty procedure performed to stabilize a fracture in a vertebra of a patient comprising the steps of performing a vertebroplasty procedure to stabilize a fracture in a vertebra of the patient, wherein the vertebroplasty procedure comprises the step of injecting a material into the fractured vertebra, wherein the material is formed by mixing together a first paste and a second paste, wherein the first paste comprises at least one of a polymerizable monomer and a filler, and wherein the second paste comprises at least one of a polymerizable monomer and a filler.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: February 11, 2014
    Assignee: Orthovita, Inc.
    Inventors: Theodore D. Clineff, Maarten Persenaire, Gina M. Nagvajara, Marissa M. Darmoc, Matthew B. Havener, Stephen G. Gilbert, Erik M. Erbe
  • Publication number: 20140039088
    Abstract: Dental composition comprising (i) a particulate filler; (ii) a polymerizable hydrolysis-stable compound of the following formula (1) AXn wherein A is a linker group containing at least n nitrogen atoms and optionally one or more acidic groups, X are moieties containing a polymerizable double bond and forming an amide bond with a nitrogen atom of A, which X may be the same or different and are represented by the following formula (2) wherein R1 and R2 are independent from each other and represent a hydrogen atom, a C1-6 alkyl group or a group —(CH2)m—Z, wherein Z is COOM, OPO3M2, PO3M2, SO3M, and M is independently a hydrogen atom or a metal atom, and m is an integer of from 0 to 6, L is a bond, a C1-6 alkylene group; and n is an integer of at least 1; provided that at least one X cannot be a (meth)acryl group; and (iii) an initiator system.
    Type: Application
    Filed: October 18, 2011
    Publication date: February 6, 2014
    Applicant: DENTSPLY DETREY GMBH
    Inventors: Simon Stelzig, Joachim E. Klee, Andreas Facher, Christoph Weber
  • Patent number: 8642678
    Abstract: Polymerizable dental composite comprising a solid filler and an organic polymerizable matrix, said polymerizable matrix comprising: (i) a polymerizable (meth)acrylic monomer having at least two polymerizable groups and (ii) from 1.0 to 15 weight-% of a polymerizable monomer having a carboxylic acid group based on the total weight of said polymerizable matrix.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: February 4, 2014
    Assignee: DENTSPLY International Inc.
    Inventors: Gordon B. Blackwell, Andreas Facher
  • Patent number: 8642679
    Abstract: To provide a dental glass ionomer cement for a sealer to be used for sealing a gap between a gutta-percha point filled in a root canal in a dental root canal treatment and a root canal wall, with a prolonged setting time and with sufficient setting property even in a root canal having much water content, the dental cement for a sealer includes a polymer of ?-? unsaturated carboxylic acid, oxide powder capable of reacting with the polymer of ?-? unsaturated carboxylic acid, and water, and further includes an organic acid salt of metal selected from Mg, Ca, and Sr and/or a hydroxide of metal selected from Mg, Ca, and Sr.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: February 4, 2014
    Assignee: GC Corporation
    Inventors: Koji Tanaka, Hideki Yarimizu, Hisashi Nakaseko
  • Patent number: 8642064
    Abstract: A method of producing a self-hardening, bioabsorbable composite material, the material produced and its areas of application are described. The method is based on the principal method steps (I) immobilisation of a polymerisation initiator in a microporous pore system of a first partial amount of a bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material, (II) immobilisation of a polymerisation activator in the microporous pore system of a second partial amount of the bioabsorbable calcium phosphate used in producing the self-hardening, bioabsorbable composite material and (III) homogeneous mixing of the components according to (I) and (II) with a liquid or paste-form, multi-functional monomer capable of forming a biocompatible, bioabsorbable polymer network or a corresponding monomer mixture and, optionally, with further constituents which modify the properties of the monomer or monomer mixture.
    Type: Grant
    Filed: November 25, 2004
    Date of Patent: February 4, 2014
    Assignee: Curasan AG
    Inventors: Matthias Schnabelrauch, Sebastian Vogt, Ute (Erbe) Reif
  • Publication number: 20140031451
    Abstract: A paste contains at least one monomer for radical polymerisation, at least one polymer that is soluble in said at least one monomer for radical polymerisation, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerisation. The filling agent is a particulate inorganic calcium salt comprising the following properties: at least 90% by weight of the particulate inorganic calcium salt have a particle size of less than 63 ?m, as determined by means of sieve analysis; and the solubility in water of the particulate inorganic calcium salt at 20° C. is less than 8.5 g per litre. A kit and the paste is usable for mechanical fixation of articular endoprostheses, for covering skull defects, for filling bone cavities, for femuroplasty, for vertebroplasty, for kyphoplasty, for the manufacture of spacers or for the production of carrier materials for local antibiotics therapy, as well as a form body.
    Type: Application
    Filed: July 24, 2013
    Publication date: January 30, 2014
    Applicant: Heraeus Medical GmbH
    Inventor: Sebastian Vogt
  • Publication number: 20140031452
    Abstract: A material or biomaterial comprising silicic acid condensates having a low degree of cross-linking, and methods for its production are subject-matter of the invention. A method for the production of silicic acid structures having a low degree of cross-linking is disclosed, wherein a sol is produced, wherein further condensation is prevented when specific cross-linking of the silicic acid is reached, wherein, preferably, structures having a size of 0.5-1000 nm are produced, e.g. polyhedral structures or aggregates of the same. Further condensation can be prevented by means of mixing with a polymer. In one embodiment, this comprises nano-structured, silicon dioxide (SiO2) having a low degree of cross-linking that is embedded in a polymer matrix. The material can be used in medicine for therapeutic purposes, and can enter into direct contact with biological tissue of the body in this connection.
    Type: Application
    Filed: January 31, 2012
    Publication date: January 30, 2014
    Inventor: Thomas Gerber
  • Publication number: 20140024739
    Abstract: Paste containing at least one monomer for radical polymerization, at least one polymer that is soluble in said at least one monomer for radical polymerization, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerization, wherein the filling agent is a particulate inorganic filling agent possessing a BET surface of at least 40 m2/g; kit comprising pastes A and B which, when mixed, form paste C, which pastes are useful for mechanical fixation of articular endoprostheses, for covering skull defects, for filling bone cavities, for femuroplasty, for vertebroplasty, for kyphoplasty, for the manufacture of spacers or for the production of carrier materials for local antibiotics therapy, as well as a form body produced from the pastes.
    Type: Application
    Filed: July 18, 2013
    Publication date: January 23, 2014
    Inventor: Sebastian VOGT
  • Publication number: 20140005794
    Abstract: The present invention relates to a granulated material mixture for regenerating bone, in particular by way of three-dimensional callus distraction, and to uses of said granulated material mixture. The granulated material mixture comprises rigid and deformable granulated materials.
    Type: Application
    Filed: March 10, 2012
    Publication date: January 2, 2014
    Applicant: CELGEN AG
    Inventor: Domonkos Horvath
  • Publication number: 20140005635
    Abstract: A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.
    Type: Application
    Filed: August 29, 2013
    Publication date: January 2, 2014
    Applicant: DePuy Synthes Products, LLC
    Inventors: Andreas Boger, Christoph Sattig, Stefan Deusser
  • Patent number: 8618188
    Abstract: A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: December 31, 2013
    Assignee: DePuy Synthes Products, LLC
    Inventors: Elliott Gruskin, Andreas Boger, Andrea Montali, Kurtis Wheeler
  • Patent number: 8614263
    Abstract: A non-biodegradable endodontic sealant composition comprises the reaction product of a first paste and a second paste. Either paste or both pastes include one or more of: unmodified HEMA and bioglass. The first paste includes a first polymerizing agent and the second paste includes a second polymerizing agent. A method for making the composition comprises preparing the first paste and second paste and combining the pastes under conditions to achieve a polymerization reaction initiated by a reaction between the polymerizing agents. The combining step is performed under conditions for achieving a setting time that is in a range of about 1 minute to about 1 hour. A method for treating humans having a voided region into which no re-growth will occur comprises administering the composition to the affected area, preferably to an area where tissue, tooth, or bone are not intended to re-grow.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: December 24, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Francis K. Mante, Miri Kim, Syngcuk Kim
  • Publication number: 20130338252
    Abstract: Dental cement composition comprising a polymerizable polyacidic polymer having repeating units in the polymer backbone, a polymerizable monomer having at least one polymerizable functional group; a radical polymerization initiator.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 19, 2013
    Applicant: DENTSPLY INTERNATIONAL INC.
    Inventors: Joachim E. Klee, Helmut Ritter, Sven Pohle, Oliver Elsner, Mareike Bardts
  • Patent number: 8609746
    Abstract: A bone cement composition which contains large-diameter (meth)acrylate polymer particles having an average particle diameter of 10 to 60 ?m, small-diameter (meth)acrylate polymer particles having an average particle diameter of 0.1 to 2.0 ?m, a (meth)acrylate monomer and a polymerization initiator, wherein the content of the small-diameter (meth)acrylate polymer particles is 5 to 30% by mass based on the total mass of the small-diameter (meth)acrylate polymer particles and the large-diameter (meth)acrylate polymer particles, and a part or a whole of the small-diameter (meth)acrylate polymer particles are contained in the form of aggregates having an average particle diameter of 30 to 50 ?m.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: December 17, 2013
    Assignees: Kyoto University, Ishihara Sangyo Kaisha, Ltd.
    Inventors: Takashi Nakamura, Koji Goto, Takehiro Shibuya, Yoshimichi Ueda, Tokuo Suita, Masashi Imamura, Hiroaki Nishii
  • Publication number: 20130324635
    Abstract: A dental curable composition includes: a radically polymerizable monomer; a polymerization initiator; and a hyperbranched polymer, in which the hyperbranched polymer includes a unit structure represented by the general formula (I) and unit structures represented by the general formula (IIA) and/or the general formula (IIB) (in the general formula (I), A represents a single bond for bonding C and R1, >C?O, —O—, or —COO—, R1 represents a divalent saturated aliphatic hydrocarbon group or a divalent aromatic hydrocarbon group, and R2 represents a hydrogen atom or a methyl group; and in the general formula (IIA) and the general formula (IIB), R3, R4, and R5 each represent a hydrogen atom, an alkyl group, an alkoxycarbonyl group, an aryl group, or a cyano group, and R6 represents an alkylene group).
    Type: Application
    Filed: February 10, 2012
    Publication date: December 5, 2013
    Applicant: TOKUYAMA DENTAL CORPORATION
    Inventors: Tomonao Shimizu, Tatsuya Yamazaki, Hideki Kazama, Hironobu Akizumi
  • Patent number: 8598251
    Abstract: A kit is provided based on two pastes designed to produce bone cement with high initial stability and therefore low post-cure. The kit includes a paste A and a paste B, wherein paste A contains (a1) a polymerizable monomer having a pH in water in the range of 5-9, (a2) a filling agent insoluble in (a1), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbiturates, 1,3,5-trisubstituted barbiturates, and 1,3,5-tetrasubstituted barbiturates, and paste B contains (b1) a polymerizable monomer having a pH in water in the range of 5-9, (b2) a filling agent insoluble in (b1), (b3) a peroxide soluble in (b1), (b4) a heavy metal compound insoluble in (b1) and selected from the group consisting of heavy metal salts and heavy metal complexes, and wherein at least one of the pastes A and B contains a halide salt.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: December 3, 2013
    Assignee: Heraeus Medical GmbH
    Inventors: Sebastian Vogt, Hubert Büchner
  • Publication number: 20130310481
    Abstract: A dental cement composition comprising more than 50% by weight Portland cement, and characterized in that it further comprises a polymer selected from styrene, vinyl, and acrylic polymers carrying a sulfonate function.
    Type: Application
    Filed: February 3, 2012
    Publication date: November 21, 2013
    Applicant: S.A.S. CERAVERBIOTECH
    Inventors: Bertrand De Lambert, Daniel Blanquaert
  • Patent number: 8586101
    Abstract: The invention refers to an artificial bone mineral substitute material which comprises at least one ceramic and at least one water soluble non-ionic X-ray contrast agent. The invention refers to a composition for producing the same, which further comprises an aqueous liquid, as well as the use of the composition as a X-ray contrast medium.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 19, 2013
    Assignee: Bone Support AB
    Inventor: Lars Lidgren
  • Publication number: 20130302513
    Abstract: Disclosed herein are acrylic and methacrylic acid ester-based polymeric materials containing as flexibilizing and brittleness reducing agents 1-60% of C4-C8 polyalkylene or polyalkyldiene compounds, preferably having a molecular weight of 300-2100, and the use of such materials in dentistry and medicine.
    Type: Application
    Filed: July 12, 2013
    Publication date: November 14, 2013
    Inventors: Jan A. Orlowski, David V. Butler, Alice Chin
  • Publication number: 20130303655
    Abstract: The invention relates to a dental composition having a) compound (A) with the following features: only one backbone unit (U) with 6 to 20 carbon atoms, at least 6 carbon atoms thereof forming an aromatic or an aliphatic cyclic moiety, the remaining carbon atoms either being part of substituents pending from the cyclic moiety or being part of bridging groups to spacer units, wherein one or more of the remaining carbon atoms can be replaced by an oxygen atom, the backbone unit not comprising a bisphenol structure, one or two spacer unit(s) (S) being connected to the backbone unit (U) via an ether linkage, at least one spacer unit (S) having a —CH2-CH2-CH2-CH2-O—CH2-CH(Q)-OG chain or a —CH2-CH(OG)-CH2-OM residue or a mixture of these two types of spacers within one spacer unit, with G having at least one group selected from acroyl, methacroyl, acetyl, benzoyl, and combinations thereof, M having at least one aryl group, and combinations thereof, Q having at least one group selected from hydrogen, methyl, phenyl,
    Type: Application
    Filed: January 12, 2012
    Publication date: November 14, 2013
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Adrian S. Eckert, Michael M. Cub, Bettina Hailand, Marion B. Kestel, Karsten Dede, Uwe H. Hoheisel, Gioacchino Raia, Christoph Thalacker, Reinhold Hecht, Thomas Luchterhandt
  • Patent number: 8580865
    Abstract: The invention relates to a phase and sedimentation-stable, plastically deformable preparation with intrinsic pore formation that can be used for instance for filling bone defects and for augmentation, and also relates to a method for producing same.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: November 12, 2013
    Assignee: Curasan AG
    Inventors: Fabian Peters, Christiane Hoffmann, Kathleen Hasanovic
  • Patent number: 8575274
    Abstract: The present invention relates to bone cements and, more particularly, to multi-solution bone cements and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, thereby providing for a significant increase in the polymer-to-monomer (P:M) ratio. Another embodiment of the present invention provides cross-linked PMMA beads which are surface modified with unsaturated carbon double bonds. A further embodiment of the present invention provides multi-solution bone cements made with PMMA-PMMA spherical brush polymers.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: November 5, 2013
    Assignee: Syracuse University
    Inventors: Julie M. Hasenwinkel, Imad K. Merkhan, Jeremy L. Gilbert
  • Publication number: 20130281566
    Abstract: The present invention relates to a kit comprising a paste A and a paste B, whereby (a) paste A contains (a1) at least one monomer for radical polymerisation; and (a2) at least one barbituric acid derivative as polymerisation initiator; (b) paste B contains (b1) at least one monomer for radical polymerisation; (b2) at least one heavy metal compound as polymerisation accelerator that is selected from the group consisting of heavy metal salts and heavy metal complexes; (b4) at least one alkali or alkaline earth halide; and (b5) at least one complexing agent for the alkali ions or alkaline earth ions (b4) that contains at least two ether groups; and whereby at least one of the pastes A and B contains, as component (a3) and/or (b3), at least one filling agent that is insoluble in (a1) and/or (b1), respectively.
    Type: Application
    Filed: January 29, 2013
    Publication date: October 24, 2013
    Inventor: Sebastian Vogt
  • Patent number: 8557893
    Abstract: Substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions are described. In one embodiment, the substituted saccharide amide compound comprises a hydrophobic group and at least one free-radically polymerizable group with the proviso that the hydrophobic group is not bonded to the ethylenically unsaturated carbon atom of the free-radically polymerizable group. The hydrophobic group is typically bonded to a nitrogen atom of a saccharide amine residue or a carbonyl moiety of saccharide amide residue.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: October 15, 2013
    Assignee: 3M Innovative Properties Company
    Inventors: Jie Yang, Sumita B. Mitra, Yi He, Brian A. Shukla, Naimul Karim, Afshin Falsafi, Richard B. Ross, Paul R. Klaiber, George W. Griesgraber
  • Publication number: 20130264244
    Abstract: The present invention relates to a bone cement precursor system that is presented in the form of two shelf-stable pastes which have been terminally sterilized and are held in separate containers during product transport and storage. When the product is used during surgery, these pastes inject to a site of application through a static mixing device by the action of applied injection force. When the two pastes are mixed, they start to react to each other while injecting out. The resulting composition is highly biocompatible, osteoconductive, injectable, rapid setting and bioresorbable, and is useful in connection with bone repair procedures, for example, in the craniomaxillofacial, trauma and orthopedic areas.
    Type: Application
    Filed: June 6, 2013
    Publication date: October 10, 2013
    Inventors: Donal O'Mahony, Venkat R. Garigapati, Adrian Sun Wai, Brian Hess, Matthew E. Murphy
  • Patent number: 8552088
    Abstract: A cement for dental use, containing a first agent and a second agent, wherein both of the first agent and the second agent contain a polymerizable monomer (a) and a filler (b), wherein the first agent and/or the second agent further contains a photopolymerization initiator (c), wherein further as a chemical polymerization initiator (d), either one of the first agent and the second agent contains an oxidizing agent (f) and the other contains a reducing agent (g), the oxidizing agent (f) and the reducing agent (g) constituting a redox polymerization initiator, wherein the photopolymerization initiator (c) contains an ?-diketone, and the photopolymerization initiator (c) is contained in a total amount of from 0.010 to 0.100 parts by weight, based on 100 parts by weight of the total amount of the polymerizable monomer (a), wherein the chemical polymerization initiator (d) is contained in a total amount of from 0.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: October 8, 2013
    Assignee: Kuraray Noritake Dental Inc.
    Inventors: Hiroki Shinoda, Mitsuru Takei, Hidemi Nakayama
  • Patent number: 8552087
    Abstract: Low viscosity composites, with a flexural modulus of at least 18 GPa and a flexural strength of at least 90 MPa for filling dental root canals for fixing post or as a build-up material on post, are composed of aluminum oxide with a mean particle size of 1 to 50 ?m in combination with at least one additional filler with a mean particle size of 0.5 to 5 ?m and a monomer mixture. Also disclosed is a method for the preparation of tooth restorations.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: October 8, 2013
    Assignee: Ivoclar Vivadent AG
    Inventor: Gianluca Zappini
  • Publication number: 20130261218
    Abstract: Method for adjusting or improving or optimising the usage properties of filler(s)-containing, flowable dental material, which involves relating to at least one measuring value representing the tackiness to at least one measuring value representing the texturing or plasticity or consistency. Flowable, usage-optimised, usually non-polymerised dental composites contain, as fillers, at least one glass filler and at least one filler from the group of chipped polymers or pre-polymer fillers based on ground polymer that is pre-polymerised together with inorganic particles, and, as additive(s), at least one compound represented through formula H—Y—Z (I), where: Y?—O—, —S—, —CO—, —OSi(OR1)2—, —OE Z?H, OH, SH, NH2, COOH, COOR2 E=—CnHmOp- R1?H, C1-C4-Alkyl R2?C1-C15-Alkyl, interrupted by one or more O atoms.
    Type: Application
    Filed: March 13, 2013
    Publication date: October 3, 2013
    Inventors: Andreas UTTERODT, Kurt REISCHL, Nelli SCHÖNHOF, Michael ECK, Christine HIERSEKORN, Jutta SCHNEIDER
  • Publication number: 20130261217
    Abstract: A bone cement comprising a first component and a second component, wherein contacting the first component and the second component produces a mixture which attains a high viscosity an initial period and the viscosity of the mixture remains relatively stable for a working time of at least 5 minutes after the initial setting period, and the mixture is suitable for in-vivo use.
    Type: Application
    Filed: March 11, 2013
    Publication date: October 3, 2013
    Applicant: DEPUY SPINE, INC.
    Inventors: Mordechay Beyar, Oren Globerman, Ronen Shavit, Hila Wachsler-Avrahami
  • Patent number: 8546462
    Abstract: A bone cement is provided that includes a solid component and a liquid component. The solid component and liquid component are mixed together to form the bone cement. After completion of the solid and liquid component mixing, the bone cement has an initial viscosity effective for manual application or manual injection onto or into a targeted anatomical location, e.g., bone, and the cement has stable viscosity range that over both time and temperature is effective for uniformly filling the targeted anatomical location, for example an osteoporotic bone or a fractured vertebral body, with minimal to no leakage of the cement from the targeted anatomical location. Additionally, both the initial viscosity and the stable viscosity of the bone cement are within a range that renders the bone cement effective for injection with a manually operated syringe or multiple syringes.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: October 1, 2013
    Assignee: DePuy Synthes Products, LLC
    Inventors: Andreas Boger, Christoph Sattig, Stefan Deusser
  • Patent number: 8536243
    Abstract: The invention relates to a system for preparing a polymerized bone cement, including two components reacting with each other when they are mixed to form a solid polymer material. The first component may include a biocompatible acrylic polymer and an initiator capable of initiating a polymerization reaction. The second component may include a monomer capable of dissolving an acrylic polymer, a polymerization activator and a polymerization inhibitor, system in which the second component also includes a biocompatible acrylic polymer dissolved in said monomer, identical or different from the polymer of the first component with an average molar mass greater than 1,000,000 g/mol and a residual initiator content of less than 0.1% to form a gel with determined viscosity. Another object of the invention is a composition designed to constitute the second component of as system used to prepare such cement.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: September 17, 2013
    Assignee: Teknimed SAS
    Inventors: Alain Leonard, Cyril Sender, Claudine Lavergne, Benoît Donazzon
  • Publication number: 20130236399
    Abstract: The present invention relates to an apatite composition comprising 0.001-99.999 wt. % of an apatite and 0.001-99.999 wt. % of a glass carbomer, based on the total weight of the apatite composition. The apatite is preferably a fluoroapatite according to the general formula (I): wherein: M is a cation other than Ca2+, B is an anion other than P043?, A is F?, 0?x?9, 0?y?5, and 0?z?2, and most preferably Ca10(PO4)6F2. The apatite composition is advantageously used as a dental filling material, a denting bonding cement, a bone cement, a bone replacing material, in dental care and cleansing products, glass-ceramics, bone scaffolds and bone substrates, and as a coating material for crowns and bridges.
    Type: Application
    Filed: July 8, 2011
    Publication date: September 12, 2013
    Inventors: Willem Frederik van den Bosch, Raimond Nicolaas Bruno Van Duinen
  • Publication number: 20130225716
    Abstract: Disclosed herein are acid-neutralizing polymerizable and/or non-polymerizable resins, methods of making such resins, and dental compositions having such resins.
    Type: Application
    Filed: February 22, 2013
    Publication date: August 29, 2013
    Applicant: DENTSPLY INTERNATIONAL INC.
    Inventors: Xiaoming Jin, Huaibing Liu