Composition Suitable For Use As Tooth Or Bone Replacement, Restorative, Or Implant Patents (Class 523/115)
  • Patent number: 10758457
    Abstract: Provided is a curable composition including a polymerizable monomer component (A), a spherical filler (B) having an average particle size within the range of 230-1000 nm, and a polymerization initiator (C), wherein the curable composition is characterized by having a value (V) of less than 5 and a chroma (C) of 0.05 or higher in colorimetric values according to the Munsell Color System in colored light on a black background, and a value (V) of 6 or higher and a chroma (C) of less than 2 in colorimetric values according to the Munsell Color System in colored light on a white background, each of the values (V) and chroma (C) being measured using a color difference meter in a state in which a 1-mm-thick cured article has been formed.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 1, 2020
    Assignee: TOKUYAMA DENTAL CORPORATION
    Inventors: Hironobu Akizumi, Chika Toriyabe
  • Patent number: 10709529
    Abstract: The present invention relates to a kit of parts comprising a dental mill blank comprising a porous zirconia material and a colouring solution for colouring the porous zirconia material. The porous zirconia material comprises Zr oxide calculated as ZrO2: from 80 to 97 wt.-%, Al oxide calculated as Al2O3: from 0 to 0.15 wt.-%, Y oxide calculated as Y2O3: from 1 to 10 wt.-%, Bi oxide calculated as Bi2O3: from 0.01 to 0.2 wt.-%, the porous zirconia material not comprising Fe calculated as Fe2O3 in an amount of more than 0.01 wt.-%, wt.-% with respect to the weight of the porous zirconia material. The colouring solution comprises solvent(s), colouring agent(s) comprising metal ions selected from Tb, Er, Pr, Mn or combinations thereof, the solution not comprising Fe ions in an amount of more than 0.01 wt.-%, the solution not comprising Bi ions in an amount of more than 0.01 wt.-%, wt.-% with respect to the weight of the colouring solution.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Michael Jahns, Hans R. Schnagl
  • Patent number: 10703052
    Abstract: A method and apparatus for producing a composite part are provided to enable composite parts to be assembled with precise control over the orientation and spatial distribution of reinforcing or other particles within a matrix material. The method and apparatus use magnetic fields applied during various additive manufacturing processes to achieve complex particles orientations within each layer of the part. The composite parts can achieve enhanced properties, including mechanical, thermal, electrical and optical properties.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: July 7, 2020
    Assignee: Northeastern University
    Inventors: Randall Erb, Joshua J. Martin
  • Patent number: 10703906
    Abstract: Compositions that are curable to polythioether polymers are provided, comprising: a) a dithiol monomer; b) a diene monomer; c) a radical cleaved photoinitiator; d) a peroxide; and e) an amine; where the peroxide and amine together are a peroxide-amine redox initiator. In some embodiments, the amine is a tertiary amine. In some embodiments, the amine is selected from the group consisting of dihydroxyethyl-p-toluidine, N,N-diisopropylethylamine, and N, N, N?, N?, N?-pentamethyl-diethylenetriamine. In some embodiments, the peroxide is selected from the group consisting of di-tert-butyl peroxide, methyl ethyl ketone peroxide, and benzoyl peroxide. In some embodiments, the composition may additionally comprise a polythiol monomer having three or more thiol groups.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 7, 2020
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Sheng Ye, Junting Li, Yizhong Wang, Joel D. Oxman, Susan E. DeMoss, Jonathan D. Zook
  • Patent number: 10695461
    Abstract: A dried implant composition for preparing an injectable aqueous implant formulation that is extrudable through a tapering system and a gauge 18 cannula, including a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 ?m and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve; an injectable aqueous implant formulation for use in a method of oral tissue regeneration, wherein the injectable aqueous implant formulation is obtainable by hydration and homogeneous mixing; a process for preparing the injectable aqueous implant formulation; and a kit for preparing the injectable aqueous implant formulation for use in oral tissue regeneration.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 30, 2020
    Assignee: Geistlich Pharma AG
    Inventors: Daniel Suppiger, Paul Buxton, Nino Kurz
  • Patent number: 10653586
    Abstract: To provide a cured product having high fracture energy, provided are a curable composition, including: organic-inorganic composite particles; (a polymerizable monomer; a polymerization initiator; and inorganic particles, in which a cured body formed by curing the curable composition includes: a matrix formed by curing all constituent components of the curable composition except for the organic-inorganic composite particles; and the organic-inorganic composite particles dispersed and contained in the cured body, and in which an elastic modulus M of the matrix is larger than an elastic modulus P of the organic-inorganic composite particles by 3.0 GPa or more, a curable composition for dental use, and an organic-inorganic composite particle for dental use.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: May 19, 2020
    Assignee: TOKUYAMA DENTAL COOPERATION
    Inventors: Junichiro Yamagawa, Tatsuya Yamazaki, Takuma Matsuo, Takuya Suzuki
  • Patent number: 10590311
    Abstract: Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for two part curable compositions are provided.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 17, 2020
    Assignees: Henkel IP & Holding GmbH, Henkel AG & Co. KGaA
    Inventors: David P. Birkett, Anthony F. Jacobine, Andrew D. Messana, Joel D. Schall, David Mullen, Martin Wyer, Lynnette Hurlburt
  • Patent number: 10538460
    Abstract: A ceramic slurry for forming a ceramic article includes a binder, a first plurality of ceramic particles having a first morphology, a second plurality of ceramic particles having a second morphology that is different from the first morphology; and a photoinitiator. A method for using this slurry for fabricating ceramic articles is presented as well.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: January 21, 2020
    Assignee: General Electric Company
    Inventors: Cathleen Ann Hoel, Xi Yang, Michael Joseph O'Brien
  • Patent number: 10519319
    Abstract: The present invention provides a three-dimensional printing article for making dental products and the preparation method thereof, which comprises: Ethoxylated bisphenol A dimethacrylate, Diurethane dimethacrylate, Triethylene glycol dimethacrylate, and Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide. It not only improves the present time-consuming and labor-intensive dental device making, but also can be used in mass production of dental devices.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: December 31, 2019
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Yuan-Min Lin, Hsuan Chen, Shyh-Yuan Lee, Pin-Ju Huang
  • Patent number: 10485735
    Abstract: Described herein are compositions and methods which produce hydrolytically stable resin monomers, bioactive fillers, phosphorus coupling agent and surface coating method, which can be combined to produce new generation dental composites; compositions comprising the same, as well as methods of making and using the same are also described.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: November 26, 2019
    Assignee: HOWARD UNIVERSITY
    Inventors: Tongxin Wang, Lawrence C. Chow
  • Patent number: 10485898
    Abstract: High strength biomedical materials and processes for making the same are disclosed. Included in the disclosure are nanoporous hydrophilic solids that can be extruded with a high aspect ratio to make high strength medical catheters and other devices with lubricious and biocompatible surfaces.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: November 26, 2019
    Assignee: Access Vascular, Inc.
    Inventors: James F. Biggins, Michael Bassett, Daniel Donahue
  • Patent number: 10420860
    Abstract: Coatings, materials, and devices with biohealing properties are described. A biohealing coating may include a base material and biohealing particles. The base material may include a polymer. The biohealing particles may include one or more of metal particles, alloy particles, metal oxide particles, carbon particles, carbide particles, and nitride particles. The biohealing coating may be applied to an implantable device. A biohealing material may include a base material in bulk form and biohealing particles. The biohealing material may be used to manufacture an implantable device. An implantable device may include one or both of a biohealing coating and a biohealing material.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: September 24, 2019
    Inventor: Kondapavulur T. Venkateswara-Rao
  • Patent number: 10376611
    Abstract: A synthetic bone graft is described which is adapted to be received within a bone defect and which is structurally load-bearing. The bone graft comprises an entirely synthetic graft body corresponding in shape and size to the bone defect. The graft body is composed of a plurality of superimposed multilayered structures, each of the multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween. The biomineral layer has a stiffness that is greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is less than that of the biomineral layer.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: August 13, 2019
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Francois Barthelat, Michael Tanzer, Sacha Cavelier
  • Patent number: 10357511
    Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 23, 2019
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
  • Patent number: 10265248
    Abstract: A composite material including silanated filler and mixed polymerizable monomer, having a stable pasty property which keeps well and has a consistent usability. A composite material containing a silanated filler, a polymerizable monomer, and a polymerization initiator, and may be produced by a process which includes in order of a mixed polymerizable monomer preparing step, a mixed polymerizable monomer preserving step, a composite material preparing step, a composite material preserving step, a composite material filling step, and a small quantity preserving container preserving step.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: April 23, 2019
    Assignee: SHOFU INC.
    Inventors: Yusei Kadobayashi, Masako Shigezawa
  • Patent number: 10213367
    Abstract: Radically polymerizable dental material, which contains at least one compound of Formula I: and at least one thermolabile radically polymerizable compound and/or at least one photolabile radically polymerizable compound. The materials are characterized by debonding-on-demand properties.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: February 26, 2019
    Assignee: Ivoclar Vivadent AG
    Inventors: Norbert Moszner, Kai Rist, Iris Lamparth, Peter Burtscher, Christian Gorsche, Robert Liska
  • Patent number: 10004806
    Abstract: A periodontal structure regeneration composition for treatment of periodontal disease is a mixture of particles of a bone growth material and free collagen. All particles are sized to be less than 1 mm in diameter. The periodontal regeneration composition is injected into the periodontal pocket through an 18 gauge needle. The composition may contain a thickener that increases the viscosity of the composition after the material has been injected into the periodontal pocket. The composition is available in pre-filled syringes offered in a kit that may also contain strips of surgical sponge or gauze that are sized to fit within a periodontal pocket, a time of adhesive, a dental bur, a probe, a gauze placement tool, gauze counter and a brush for cleaning the dental bur.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: June 26, 2018
    Assignee: Periovance, Inc.
    Inventor: Dennis W. Szymaitis
  • Patent number: 9814655
    Abstract: Described herein is a dental filler material having a core made of a core material and a shell made of a shell material, where the shell material coats or covers at least a portion of the core.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 14, 2017
    Assignee: Dentsply International Inc.
    Inventors: Yang Cai, Xiaoming Jin, Xin Huo
  • Patent number: 9717822
    Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: August 1, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
  • Patent number: 9603779
    Abstract: A composite material including silanated filler and mixed polymerizable monomer, having a stable pasty property which keeps well and has a consistent usability. A composite material containing a silanated filler, a polymerizable monomer, and a polymerization initiator, and may be produced by a process which includes a mixed polymerizable monomer preparing step, a silanation step, a silanated filler preserving step, a composite material preparing step, a composite material preserving step, a composite material filling step, and a small quantity preserving container preserving step.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: March 28, 2017
    Assignee: SHOFU INC.
    Inventors: Yusei Kadobayashi, Masako Shigezawa
  • Patent number: 9545377
    Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: January 17, 2017
    Assignee: BioMimetic Therapeutics, LLC
    Inventor: Samuel E. Lynch
  • Patent number: 9351908
    Abstract: Orthodontic adhesives are claimed which use polymeric filler particles with defined particle size characteristics. The particle size characteristics are controlled such that these adhesives provide comparable mechanical retention and cohesive strength of conventional orthodontic adhesives when used to bond orthodontic appliances to teeth. Because polymeric fillers are generally softer than inorganic fillers, these adhesives are easier to remove from the tooth than conventional adhesives after debonding an orthodontic appliance. Embodiments of the invention include both self-curing and two-part adhesives, packaged adhesive-coated orthodontic appliances, and methods for removing a cured adhesive from a tooth surface.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: May 31, 2016
    Assignee: 3M Innovative Properties Company
    Inventors: Rajdeep S. Kalgutkar, David T. Amos, Taun L. McKenzie
  • Patent number: 9345647
    Abstract: Polymerizable compositions are provided that contain an epoxy compound and a polymerizable, ethylenically-unsaturated resin having an acid functional group where the epoxy compound is polymerized by cationic polymerization initiated by the acid functional group and the polymerizable, ethylenically-unsaturated resin is polymerized by free-radical polymerization. To that end, a two-part polymerizable composition is provided that has a first part containing the epoxy compound; and a second part containing the polymerizable, ethylenically-unsaturated resin having an acid functional group. The first part and/or the second part further contain a radical initiator effective to initiate either self-curing or light-curing by free-radical polymerization.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: May 24, 2016
    Assignee: Pentron Clinical Technologies, LLC
    Inventors: Shuhua Jin, Weitao Jia
  • Patent number: 9273164
    Abstract: Diaminospirobisindane diols, curable compositions, curative compositions, cured articles, and methods of curing are described.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: March 1, 2016
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Werner M. A. Grootaert, Michael S. Wendland, George W. Griesgraber
  • Patent number: 9273222
    Abstract: The present invention provides: a composition including a polymer (i) which has a —SO3M group and an epoxy group, wherein M represents a hydrogen atom, an alkali metal, an alkaline earth metal or an ammonium ion, and a silane compound (ii) which has at least two hydroxy group(s), alkoxy group(s) or halogen atom(s) that are each bound to a silane atom; and a hydrophilic film obtained by curing the composition. The hydrophilic film of the present invention is excellent in its hydrophilicity, durability, abrasion resistance and weather resistance and has high antifogging, antifouling, antistatic and quick-drying (water evaporation) properties. Therefore, a variety of laminates in which the hydrophilic film of the present invention is laminated on a substrate can also be provided.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: March 1, 2016
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Koju Okazaki, Noboru Kawasaki, Kenichi Fujii
  • Patent number: 9241808
    Abstract: An implant including a first disc portion shaped and sized generally to correspond to a first intervertebral disc section having a pivot point positioned relative to a first surface opposite a second surface of the first disc portion and a lattice structure with a negative Poisson's ratio; a second disc portion being shaped and sized generally to correspond to a second intervertebral disc section having a pivot point receptacle positioned relative to a third surface opposite a forth surface of the second disc portion and a lattice structure with a negative Poisson's ratio where the first disc portion and the second disc portion are configured to exhibit an auxetic behavior when subject to compression generally perpendicular to a surface plane of the first surface and the second surface.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: January 26, 2016
    Inventor: Anthony Sabatino
  • Patent number: 9241880
    Abstract: To provide a dental glass ionomer cement composition having excellent adhesion strength to a metallic prosthesis. A dental glass ionomer cement composition includes a copolymer (A), a fluoroaluminosilicate glass powder (B) and water (C). The copolymer (A) includes a polymer or copolymer of ?-? unsaturated carboxylic acid, or includes a copolymer of ?-? unsaturated carboxylic acid and one or more kinds selected from a group of acrylamide, acrylonitrile, methacrylic acid ester, acrylates, vinyl chloride, allyl chloride and vinyl acetate. In the copolymer (A), the number of molecules of ?-? unsaturated carboxylic acid occupies 50% or more of the total number of molecules. The dental glass ionomer cement composition further includes a compound (D) which contains a sulfur atom in one molecule, includes a carboxylic group and an amino group and does not include a polymerizable group.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: January 26, 2016
    Assignee: GC CORPORATION
    Inventors: Koji Tanaka, Daisuke Ota, Hideki Yarimizu
  • Patent number: 9233188
    Abstract: The subject matter of the invention is a curable composition for use as bone cement, in particular for augmentation of osteoporotic bone tissue, comprising at least one organic polymer and at least one monomer for radical polymerization, at least one particulate inorganic additive having a BET surface of at least 40 m2/g, whereby the additive comprises covalently bound hydroxyl groups, whereby the composition further comprises at least one fatty acid ester or a mixture of fatty acid esters. Another subject matter of the invention is the use of said composition for augmentation of osteoporotic bone tissue and particularly preferably for vertebroplasty, kyphoplasty, and augmentation of drill holes in osteoporotic bone tissue, as well as a kit for producing said composition.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: January 12, 2016
    Assignee: HERAEUS MEDICAL GMBH
    Inventor: Sebastian Vogt
  • Patent number: 9211236
    Abstract: The invention provides an infiltrant for dental application that comprises crosslinking monomers. In accordance with the invention the infiltrant has a penetration coefficient PC>50 cm/s, and comprises 0.05%-20% by weight of acid-group-containing monomers.
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: December 15, 2015
    Assignee: MUHLBAUER GMBH & CO. KG
    Inventors: Stephan Neffgen, Swen Neander
  • Patent number: 9206080
    Abstract: Non-aqueous hydraulic cement compositions comprise a non-aqueous mixture of a powder composition and a non-aqueous water-miscible liquid. In one embodiment, powder composition is a Brushite or Monetite-forming calcium phosphate powder composition. In another embodiment, the powder composition comprises porous ?-tricalcium phosphate (?-TCP) granules and at least one additional calcium phosphate powder. In another embodiment, the powder composition comprises calcium silicate powder. In a further embodiment, the powder composition comprises calcium aluminate powder. In another embodiment, the powder composition is a cement composition and comprises nanopowders having a grain size of less than 1 micron. Hardened cements are formed from such hydraulic cement compositions, and methods of producing hardened cements, kits, and articles of manufacture employ such hydraulic cement compositions.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: December 8, 2015
    Assignee: OssDsign AB
    Inventors: Håkan Engqvist, Jonas Åberg
  • Patent number: 9181409
    Abstract: A method of producing an improved polyethylene, especially an ultra-high molecular weight polyethylene utilizes a sequential irradiation and annealing process to form a highly cross-linked polyethylene material. The use of sequential irradiation followed by sequential annealing after each irradiation allows each dose of irradiation in the series of doses to be relatively low while achieving a total dose which is sufficiently high to cross-link the material. The process may either be applied to a preformed material such as a rod or bar or sheet made from polyethylene resin or may be applied to a finished polyethylene part.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: November 10, 2015
    Assignee: Howmedica Osteonics Corp.
    Inventors: Aiguo Wang, John H. Dumbleton, Aaron Essner, Shi-Shen Yau
  • Patent number: 9109072
    Abstract: A curable composition includes (A) silica fine particles surface-modified with at least one silane compound including at least (A1) a polymerizable silane compound of the general formula (1), (B) a (meth)acrylate compound, and (C) a polymerization initiator, SiR1aR2bR3c(OR4)4-a-b-c??(1) wherein R1 is a C11-20 hydrocarbon group having an ethylenic unsaturated group, or a substituted C11-20 hydrocarbon group having an ethylenic unsaturated group and having an ether bond and/or an ester bond; R2 is a hydrogen atom or a C1-4 hydrocarbon group; R3 is a halogen atom; R4 is a hydrogen atom or a C1-10 hydrocarbon group; a is an integer of 1 to 3; b is an integer of 0 to 2; c is an integer of 0 to 3; the sum of a and b is 1 to 3; the sum of a, b and c is 1 to 4.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: August 18, 2015
    Assignee: SHOWA DENKO K.K.
    Inventors: Nobuyuki Takahashi, Yoshifumi Urakawa, Hideo Miyata, Shigeru Yamaki
  • Patent number: 9107980
    Abstract: The invention relates to an orthopaedic implant made of a ceramic metal composite. The composite includes one phase that is a biocompatible metal or metal alloy and a second phase of ceramic particles examples of which include carbides, nitrides and/or oxides. In some embodiments, the implant comprises a homogeneous ceramic layer as part of a multilayered composition. In some embodiments, the multilayered composition comprises a homogeneous metal layer.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: August 18, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Shilesh C. Jani, Vivek Devidas Pawar, Carolyn L. Weaver
  • Patent number: 9050392
    Abstract: The invention relates to a method for preparing a cross-linked sterile and homogeneous hydrogel for injection, characterized in that it comprises the following steps: (a) preparing an aqueous solution containing a polymer derived from cellulose and at least one water-soluble polymer, the total polymer content ranging from 0.5 and 5 wt %, preferably from 1 to 4 wt % and more preferably from 1.5 to 3 wt %; (b) optionally adding sold particles; (c) pouring the resulting liquid mixture with the optional solid particles into a vessel and closing dais vessel using a water-tight and gas-tight system; and (d) exposing said vessel containing the liquid and the optional solid particles to a radiation dose of between 5 and 50 kGy, preferably between 20 and 30 kGy, and more preferably of about 25 kGy. The invention also relates to a hydrogel obtained according to the above method and to the use thereof in medical applications.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: June 9, 2015
    Assignee: Biomatlante
    Inventors: Xavier Bourges, Serge Baroth
  • Publication number: 20150141545
    Abstract: An object of the present invention is to provide a method of producing a bearing material having excellent wear-resistance and oxidation resistance. The method of producing a bearing material 10 according to the present invention comprises molding a substrate 12 containing a radical scavenger and a polymer material; washing at least a part 16 of the substrate 12 with a washing liquid; and grafting a polymer chain having a phosphorylcholine group from at least the part 16 of the surface after washing so as to form a polymer film 30 on at least the part of the surface.
    Type: Application
    Filed: May 30, 2013
    Publication date: May 21, 2015
    Applicant: KYOCERA Medical Corporation
    Inventors: Masayuki Kyomoto, Shihori Yamane, Kenichi Saiga
  • Publication number: 20150133578
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 14, 2015
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Darmoc
  • Publication number: 20150126641
    Abstract: The present invention provides a polymerizable composition that is suitably used as a temporary cement for implant use and a mobile tooth-fixing material. The present invention is a polymerizable composition that includes an acrylic block copolymer (a) having at least one polymer block A that mainly contains a (meth)acrylic acid ester unit and that functions as a hard segment and at least one polymer block B that mainly contains an acrylic acid ester unit and that functions as a soft segment, a polymerizable monomer (b), and a polymerization initiator (c).
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Applicant: KURARAY NORITAKE DENTAL INC.
    Inventor: Kenji Suzuki
  • Publication number: 20150125823
    Abstract: The present application provides a glass composition comprising 10-50% by weight CaO, at least 15% and less than 50% by weight P2O5, less than 3% by weight Al2O3, less than 10% by weight Li2O, Na2O, and K2O combined, and 0-60% by weight of SrO, MgO, BaO, ZnO, or combinations thereof; dental compositions comprising the glass composition, and methods of making and using such dental compositions.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Inventors: Richard P. Rusin, Kevin M. Cummings, Sumita B. Mitra, Paul A. Burgio, Tsi-Zong Tzou, David S. Arney
  • Patent number: 9023916
    Abstract: A composite material and method of making and using the same is described. In particular a dental (and preferably photocurable) composite material, and the use of a composite material according to the invention as a dental material and a method for preparation of a composite material according to the invention. Also disclosed are novel radically polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a composite material according to the invention.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: May 5, 2015
    Assignee: VOCO GmbH
    Inventors: Tobias Blömker, Manfred Stepputtis, Reinhard Maletz, Manfred Thomas Plaumann
  • Publication number: 20150108694
    Abstract: Provided herein is a curable silicone composition that has high optical transparency after being cured and that is in a putty form to be hand-mixable. A curable silicone composition contains: a specific organopolysiloxane as a component (1); a specific organohydrogenpolysiloxane as a component (2); a filler as a component (3); and a catalyst as a component (4). The difference between the refractive index of one of the components (1) to (3) that has the highest refractive index and the refractive index of one of the components (1) to (3) that has the lowest refractive index is 0.1000 or less. The complex viscosity of any of constituent compositions of the curable silicon composition before the curable silicone composition is cured is 10 Pa·s to 100000 Pa·s, as measured under predetermined measurement condition.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 23, 2015
    Inventors: Shun Shimosoyama, Toshio Kitamura
  • Patent number: 9012531
    Abstract: Hardenable compositions are described comprising at least one multifunctional ethylenically unsaturated isocyanurate monomer and at least one multifunctional ethylenically unsaturated tricyclodecane monomer. In favored embodiments, the compositions further comprise filler and are suitable dental restorations.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: April 21, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Ahmed S. Abuelyaman, Adrian S. Eckert, Sumita B. Mitra, Timothy D. Dunbar, Bradley D. Craig, Chuntao Cao
  • Patent number: 9012415
    Abstract: This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions.
    Type: Grant
    Filed: March 26, 2011
    Date of Patent: April 21, 2015
    Assignee: Stemmatters, Biotecnologia e Medicina Regenerativa S.A.
    Inventors: Joana Catarina Da Silva Correia, Joaquim Miguel Antunes De Oliveira, João Manuel Teixeira De Oliveira, Rui Pedro Amandi Romero De Sousa, Rui Luis Gonçalves Dos Reis
  • Patent number: 9011150
    Abstract: The invention provides a high strength dental composition including polymerizable dental resins. The dental composition is useful as restorative material and for making various dental devices, such as artificial teeth, crowns and bridges of high strength dental polymeric material.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: April 21, 2015
    Assignee: DENTSPLY International Inc.
    Inventor: Benjamin J Sun
  • Publication number: 20150099821
    Abstract: A dental composite composition is disclosed that includes a polymerizable resin, filler particles, and at least one polymerizable stable radical. A variety of polymerizable stable radicals may be employed, including those that have a 2,2,6,6-tetramethylpiperidinyl-1-oxyl moiety. Compositions as described herein exhibit excellent mechanical strength, hardness, and flexural modulus, while also significantly decreasing shrinkage stress caused by polymerization.
    Type: Application
    Filed: October 3, 2014
    Publication date: April 9, 2015
    Inventors: Hui LU, Xiaoming JIN, Joachim E. KLEE, Bernard KOLTISKO
  • Patent number: 9000066
    Abstract: The present disclosure relates to a multi-modal shape memory polymer material comprising a blend of at least one polymer component having a first molecular weight and at least a second polymer component having a second molecular weight that is less than the first component.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: April 7, 2015
    Assignee: Smith & Nephew, Inc.
    Inventors: Malcolm Brown, Horacio Montes De Oca Balderas, Michael Hall, John Rose
  • Patent number: 8993652
    Abstract: A dual-cure curable material kit comprising: (A) a radical-polymerizable monomer component; (B) a photopolymerization initiator component comprising (b1) an ?-diketone compound, (b2) an aliphatic tertiary amine compound having a tertiary amino group in which three saturated aliphatic groups are bonded to a nitrogen atom and one of the saturated aliphatic groups has an electron-withdrawing group as a substituent, and (b3) an s-triazine compound having a trihalomethyl group as a substituent, or a diaryliodonium salt compound; and a chemical polymerization initiator component (C) comprising (c1) an organic peroxide, and (c2) an N,N-di(hydroxyalkyl)-p-toluidine compound; which is packed separately at least in two packages so that the component (b2) and the component (b3) of the photopolymerization initiator component (B) are not packed together in a single package and the component (c1) and the component (c2) of the chemical polymerization initiator component (C) are not packed together in a single package.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: March 31, 2015
    Assignee: Tokuyama Dental Corporation
    Inventors: Kyoichi Fujinami, Kazuhiko Okishio
  • Publication number: 20150079543
    Abstract: The invention relates to a hardenable dental composition comprising component (A) comprising a cationically hardenable compound, component (B) comprising an initiator being able to initiate the hardening reaction of the cationically hardenable compound, and component (C) comprising a filler, wherein the filler comprises a filler body and a filler surface, the filler surface comprising side groups with polar moieties. The invention also relates to a process of producing the dental composition, to the use of the dental composition as dental impression material and to a method of taking an impression of dental tissue.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventors: JOACHIM W. ZECH, THOMAS KLETTKE, SABASTIAN ZELLER, BERND KUPPERMANN, HENDRIK GRUPP
  • Patent number: 8969430
    Abstract: A hydroxyapatite ceramic hybrid material includes a hydroxyapatite ceramic structure having pores therein and a biodegradable polymer included in the pores in the hydroxyapatite ceramic structure. The biodegradable polymer can be a poly L-lactic acid polymer. A method for preparing a hydroxyapatite ceramic-biodegradable polymer hybrid material includes preparing a porous hydroxyapatite ceramic containing pores having an average pore diameter of 10 ?m or larger; and forming a biodegradable polymer in the pores of the porous hydroxyapatite ceramic. The porous hydroxyapatite ceramic may be prepared by: preparing a slurry comprising hydroxyapatite fibers and heat-degradable particles in a selected solvent; filtering the slurry to obtain a paste; preparing a molded body using the paste; compacting the molded body to produce a green compact; and firing the green compact at a temperature at least 1000° C. to produce a porous hydroxyapatite ceramic structure.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: March 3, 2015
    Assignee: Showa-Ika Kogyo Co. Ltd.
    Inventors: Mamoru Aizawa, Masahiro Rikukawa
  • Patent number: 8968760
    Abstract: A method for attaching an implant to tissue is disclosed. In embodiments, a method includes applying a sprayable material to tissue, the sprayable material possessing functional groups capable of binding to tissue. The sprayable material also possesses functional groups capable of binding to an implant. In embodiments, the functional groups capable of binding to an implant include nucleotides. In such a case, the implant possesses complementary nucleotides capable of binding to the nucleotides on the sprayable material, thereby permitting hydrogen binding between the two. The implant may thus be affixed to tissue, and repositioned as necessary, prior to more permanent attachment utilizing means such as sutures, tacks, etc.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 3, 2015
    Assignee: Covidien LP
    Inventors: Timothy Sargeant, Jonathan Thomas
  • Patent number: 8962708
    Abstract: The invention relates to a curable dental composition comprising a curable polyether group containing polymer as component (A), an initiator capable of initiating a curing reaction of component (A) as component (B) and a certain F-containing compound as component (C). The invention also relates to a method of production and use of the curable dental composition or a respective kit of parts for the preparation of or as impression material or for the preparation of crowns and bridges.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: February 24, 2015
    Assignee: 3M Innovative Properties Company
    Inventors: Andreas R. Maurer, Christoph Schulte, Peter U. Osswald, Joachim W. Zech, Hendrik Grupp, Peter Bissinger