Abstract: Described herein is a dental filler material having a core made of a core material and a shell made of a shell material, where the shell material coats or covers at least a portion of the core.

Abstract: The invention relates to a new biocompatible, biodegradable removable and repositionable adhesive composition, its preparation method and various uses thereof, including its use as surgical aid. The invention also discloses a matrix comprising such composition, such as e.g. a solid support covered, impregnated or saturated by said adhesive composition. Adhesive compositions according to the invention comprise at least one chitin and/or chitosan containing material. In a particular embodiment said adhesive composition further comprises at least one adhesive-enhancing agent whereby said agent is provided in a granular form, and preferably is a chitin and/or chitosan containing material as defined herein. The present adhesive composition and matrix comprising such composition can be used as gluing composition, in particular in wound-healing and/or surgical applications.

Abstract: A novel composition-of-matter, method of manufacturing thereof, and applications thereof as an adhesive, in a wide variety of different fields, and in particular, in the health care fields of medicine, dentistry, and veterinary science, for use by health care providers, such as medical, dental, and veterinary, surgeons, in procedures for reattaching or repairing body parts or components thereof, such as tissue, of (human or animal) subjects, especially under wet conditions, for example, involving adhesion of wet surfaces. The composition is comprised of a cross-linked form of a water miscible polymer, and at least one phloroglucinol type compound selected from the group consisting of: phloroglucinol, a derivative of phloroglucinol, and a polymer synthetically prepared from phloroglucinol or a derivative of phloroglucinol. An exemplary water miscible polymer is a naturally existing, or synthetically prepared, salt form of the carbohydrate alginic acid, such as sodium alginate, or alginic acid itself.

Abstract: Colorless dental compositions for restoring the enamel layer of a tooth are disclosed. The colorless enamel compositions are combined with pigmented dentin compositions to provide a true color match and natural esthetics. Methods that utilize the compositions in placement/build-up techniques in direct restorations are also disclosed.

Abstract: An orthodontic adhesive includes a curable resin monomer component; a quaternary curing initiator system; and filler. Another orthodontic adhesive having a W/C ratio (working time to curing time ratio) of at least 10, 12, 14 or 20, includes a curable resin monomer component; a curing initiator system; and filler. The adhesives are suitable as light-curing and may include a colorant. Suitable colorants include reversible, thermochromic dyes. The adhesive may also include a resin toughening component.

Abstract: The disclosure provides for self-healing hydrogels, complex structures made therefrom, and use thereof, including use of the hydrogels as self-healing coatings, self-healing sealants, tissue adhesives, and drug carriers.

Abstract: Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.

Abstract: Presently described are curable compositions comprising a mixture of at least one (e.g. free-radically) polymerizable ionic liquid and at least one other ethylenically unsaturated monomer, oligomer, or polymer. The polymerizable ionic liquid is characterized as having an air to nitrogen curing exotherm ratio of at least 0.70. Also described are articles and methods of making articles from such curable compositions. A monofunctional polymerizable ionic liquid is also described comprising a non-polymerizable substituted imidazolium cationic group and a polymerizable sulfonate anion.

Abstract: [Problems] To provide a liquid dental adhesive composition which contains a phosphoric acid-type compound having a hydrogenphosphoric diester group as an acidic group-containing polymerizable monomer and, further, contains polyvalent metal ions, effectively preventing not only the gelation but also the formation of precipitates (cloudiness) during the storage.

Abstract: The present invention relates to shape memory polymers (SMP) and especially to shape memory polymer containing a water soluble non-reactive plasticiser and to uses thereof.

Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.

Abstract: The disclosed conformable coating provides a highly durable and resilient film useful for protecting and repairing surfaces such as skin and mucous membranes. The coating comprises 0.1% to 65% wt. of a polymerized cyanoacrylate monomer and at least 35% wt. of an elastomer phase. The conformable coating composition comprises a polymerizable cyanoacrylate monomer, an elastomer, and a volatile liquid. The cyanoacrylate monomer is 0.1 to 65% wt. of the nonvolatile portion, the elastomer in an elastomer phase is at least 35% wt. of the nonvolatile portion, and the volatile liquid is at least 40% wt. of the total composition.

Abstract: [Problems] A dental adhesive composition containing an acid group-containing polymerizable monomer, that can be used as a dental adhesive material or a primer. The dental adhesive composition has excellent durability of adhesion exhibiting further improved adhering strength and durability of adhesion enabling teeth to be more strongly adhered to a composite resin or a prosthetic over extended periods of time. [Means for Solution] The dental adhesive composition contains a polymerizable monomer and ions of an element of the Group IV as basic components, at least 10 mass % of the polymerizable monomer being a polymerizable monomer having a hydrogenphosphate diester group, such as bis(2-methacryloyloxyethyl)hydrogenphosphate or 2-methacryloyloxyethylphenyl hydrogenphosphate, and the content of ions of the element of the Group IV such as titanium ions or zirconium ions in the composition being 0.1 to 1.

Abstract: This invention relates to medicine, more specifically, to surgical devices, and can be used for gluing soft body tissues. The medical glue comprises 3-methacryloxysulpholane, N-butyl-2-cyanoacrylate and at least one stabilizer.

Abstract: A primer used for pre-treating the surfaces of a prosthetic, which exhibits a large adhering force at the time of adhering a prosthetic of metal oxide ceramics to an object to be joined by using an adhesive such as a dental cement, the large adhering force being maintained for extended periods of time even in a severe environment such as in an oral cavity. A primer composition for metal oxide ceramics includes (A) a polymerizable monomer component containing 5% by mass or more, preferably, 5% by mass to 80% by mass of an acidic group-containing polymerizable monomer as represented by a 11-methacryloyloxy-1,1-undecanedicarboxylic acid and a rest of a polymerizable monomer without acidic group, such as triethylene glycol dimethacrylate; (B) polyvalent metal ions resulting from a titanium tetrabutoxide or the like; and (C) an organic solvent such as acetone or ethyl alcohol, wherein water is not substantially contained.

Abstract: The present application relates to a polymerizable dental adhesive system formulated for effective and durable bonding of zirconia based materials and restorations to dental resins and dental surfaces. According to one embodiment, a polymerizable dental adhesive system comprises a first acidic monomer comprising an ethylenically unsaturated polymerizable group or moiety of the general formula CH2?CX—C(O)— wherein X is hydrogen, methyl or a lower alkyl group, and the first polymerizable monomer further comprises a phosphoric or phosphonic acid group of general formula —OP(O)(OH)2, —OP(O)(OH), —C—P(O)(OH)2 and —C—P(O)(OH), and a second polymerizable acidic monomer comprises an ethylenically unsaturated polymerizable group or moiety of the general formula CH2?CX—C(O)— wherein X is hydrogen, methyl or a lower alkyl group, and wherein the second polymerizable acidic monomer further comprises a carboxylic acid group of the general formula —C(O)OH.

Abstract: A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.

Abstract: [Problems] To provide a chemical polymerization type curable composition which can achieve a very large strength of adhesion even without irradiated with light, and is used in the field of dental therapy. [Means for Solution] A dental curable composition comprising (A) a polymerizable monomer component containing an acidic group-containing polymerizable monomer, (B) water, and (C) a chemical polymerization initiator component comprising a radical-generating species and a reactive species that generates radicals upon reacting with the radical-generating species; wherein, the dental curable composition is stored being divided into a plurality of packages, and is polymerized and cured by mixing together the components contained in the packages; and wherein one package (I) among the packages contains the component (A) and the component (B), and, further, contains polyvalent metal ions in an amount of 0.

Abstract: An adhesive composition is provided that contains both a hydrophobic phase and a hydrophilic phase, wherein the hydrophobic phase is composed of a hydrophobic polymer composition and the hydrophilic phase is a water-absorbent blend of a hydrophilic polymer and a complementary oligomer capable of crosslinking the hydrophilic polymer through hydrogen bonding, ionic bonding, and/or covalent bonding. The composition is useful as a bioadhesive, for affixing drug delivery systems, wound dressings, bandages, cushions, or the like to a body surface such as skin or mucosal tissue.

Abstract: The invention relates generally to thin-film adhesive materials suitable for various applications. In particular, the present invention provides pliable viscoelastic thin-films configured to form strong water-resistant adhesive bonds to various surface types.

Abstract: The present disclosure provides a dental bonding agent which may comprise a composite resin containing an ingredient selected from acrylic resins, a primer comprising an amphiphile, and at least one phosphate ester, and a solvent. The dental bonding agent may be applied for resin restoration, prosthetic adhesion, enhancing adhesive strength between dentin and artificial post, and tooth coating. The present disclosure also provides a coating agent which may comprise a dental bonding agent as defined above, a pigment, and an inorganic filler.

Abstract: A radically curable polyurethane composite for dental restorations, including provisional restorations, includes polyurethane dimethacrylate prepolymers that have at least one flexible unit within a polyurethane dimethacrylate backbone, and one or more dimethacrylate monomers. Composite materials made with polyurethane dimethacrylate prepolymers of the invention exhibit superior and optimal properties of flexural strength and deflection-at-break relative to conventional dental resin composites. Composite materials of the invention also provide improved melt-resistance in response to the heat of grinding or finishing, thereby improving the fit of restorations made from the composite and preserving the finishing instruments. Methods of treating a tooth using the radically curable polyurethane composite and methods of making the polyurethane dimethacrylate prepolymers with flexible units is also provided. A kit including the radically curable polyurethane composite is also described.

Abstract: The present invention provides self-adhesive compositions that include a plurality of acidic compounds. The self-adhesive compositions are useful for applications including, for example, restoring dental structures and adhering orthodontic appliances to teeth.

Abstract: A bioadherent substrate includes a medical gel or medical gel precursor having a plurality of reactive members of a specific binding pair attached on or adapted to be attached to a surface of the medical gel, said reactive members being capable of forming covalent bonds with a plurality of complementary reactive members of the specific binding pair via a reaction selected from a Huisgen cycloaddition reaction, a Diels-Alder reaction and a thiol-ene reaction.

Abstract: The present application provides dental fillers, and methods of making and using dental fillers that include a treated surface that includes phosphorus and a divalent cation. Dental compositions including such dental fillers can be useful for delivering ions to the oral environment.

Abstract: The invention relates to a composition comprising an ethylenically unsaturated acidic compound, water, a functionalized silane, an initiator, optionally comprising a sensitising agent, a non-surface treated filler, optionally a solvent, optionally an ethylenically unsaturated compound, optionally additives selected from the group consisting of stabilizer(s), photobleachable colorant(s), fluoride release agent(s), pigments. The invention also relates to a process of producing such a composition by in-situ silanization of the non-surface treated filler.

Abstract: The present invention provides adhesive hydrogels that negatively swell at physiological temperature. By combining mussel-mimetic chemistry and the thermosensitive nature of poly(ethylene oxide)-poly(propylene oxide) copolymers, novel materials were designed that are suitable as medical sealants and adhesives.

Abstract: The present invention provides a dental adhesive material kit having excellent bond durability. The present invention is represented by a dental adhesive material kit containing a dental aqueous adhesive composition (A) and a multi-part type dental nonaqueous curable composition (B). The dental aqueous adhesive composition (A) contains a polymerizable monomer (a) having an acidic group, an aliphatic polymerizable monomer (b) having no acidic group, water (c), and an amine-based reducing agent (d1) containing no sulfur atom. The multi-part type dental nonaqueous curable composition (B) contains an aliphatic polymerizable monomer (b) having no acidic group, an aromatic polymerizable monomer (e) having no acidic group, a powdery water-soluble reducing compound (f) containing a sulfur atom, an organic peroxide (g), and an amine-based reducing agent (d2) containing no sulfur atom.

Abstract: To improve an adhesive force of an adhesive agent between an impression material and a tray, and to stabilize the adhesive force therebetween, provided is an adhesive agent for the adhesion between an alginate impression material and an impression tray for dental applications, which includes a polyamine compound having two or more amino groups in a molecule and a solvent.

Abstract: The present invention refers to a method of infiltrating enamel for the prevention and/or treatment of carious lesions comprising (a) exposing an enamel area to a conditioner comprising hydrochloric acid; (b) exposing the conditioned enamel area to an infiltrant; and (c) curing the infiltrant. The present invention further refers to a kit for carrying out the method of infiltrating enamel, which comprises a conditioner comprising hydrochloric acid and an infiltrant comprising at least one low viscous dental resin. The present invention also refers to a method for identifying an infiltrant by calculation of the penetration coefficient, and to an infiltrant identified by the method having a penetration coefficient of >50 cm/s or comprising a low viscous light curing resin having a penetration coefficient of >50 cm/s.

Abstract: The present invention provides an adhesive composition for soft tissues, an adhesive composition for wound dressing or a wound dressing composition, not only having low toxicity, low harmfulness and high adhesive strength but also being excellent in workability during application and being capable of forming films of excellent properties. The compound of the present invention is comprised a monomer (A), polymer particles (B) having a specific weight-average molecular weight and a specific volume mean particle diameter, and a polymerization initiator composition (C) containing an organoboron compound is produced.

Abstract: The application of certain (preferably photocurable) composite materials comprising a monomer with a polyalicyclic structure element as a dental sealing material is described herein. A description is also provided of novel polymerizable monomers comprising at least one polyalicyclic structure element and certain ethylenic structure elements, which are particularly suitable for use in a composite material to be applied and their application in a composite material.

Abstract: The present invention relates to a polyurea system encompassing as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which can in particular have a number average molecular weight of ?400 g/mol and an average OH functionality of 2 to 6, as component B) amino-functional compounds of general formula (I) in which X is an organic residue comprising a tertiary amino function, having no Zerewitinoff active hydrogen, R1 is a CH2—COOR3 residue, in which R3 is an organic residue having no Zerewitinoff active hydrogen, a linear or branched C1 to C4 alkyl residue, a cyclopentyl or cyclohexyl residue or H, R2 is an organic residue having no Zerewitinoff active hydrogen, n is an integer ?2 or ?3, in particular for closing, binding, bonding or covering cell tissue, and to a metering system for the polyurea system according to the invention.

Abstract: A self etching, dental cement composition is provided having the advantage of not requiring a separate etching and bonding step. The cement composition comprises a polymerizable (meth)acrylate trimellitic acid/anhydride, a phosphoric acid (meth)acrylate, a hydroxyalkyl(meth)acrylate, copolymerizable multi-functional (meth)acrylate monomers, a diluent, fillers, and a curing system. These cement compositions are prepared as a two-paste system that is combined prior to use.

Abstract: One-component heat-curable sealant composition for the protection of exposed dental surfaces, comprising (a) a polymerisable monomer and/or oligomer which has at least two polymerizable double bonds per molecule, and (b) an initiator system comprising benzoylperoxide in an amount of at least 2 wt.-% based on the total composition.

Abstract: A method of removing a dental adhesive may comprise locating the position of the dental adhesive, directing radiant energy into the dental adhesive causing the dental adhesive to weaken a bond formed with the dental adhesive, and breaking the bond by applying a suitable force to overcome the weakened bond. A dental adhesive may comprise a polymer and a dye or pigment, The dental adhesive may be formulated to cure to form a bond that is weakened in response to the dye or pigment absorbing radiant energy subsequent to curing.

Abstract: The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers.

Abstract: Polymerizable dental composite comprising a solid filler and an organic polymerizable matrix, said polymerizable matrix comprising: (i) a polymerizable (meth)acrylic monomer having at least two polymerizable groups and (ii) from 1.0 to 15 weight-% of a polymerizable monomer having a carboxylic acid group based on the total weight of said polymerizable matrix.

Abstract: An adhesive adapted for stabilizing ceramic restorations for dental use, that includes a reaction product of an admixture of: a di(organo)polysiloxane that includes at least two vinylic groups and has a viscosity of at least 100 cP at 25° C.; a silicone resin; an (organo)(hydrogen)polysiloxane; a silanated fumed silica; and a filler. Preferably, the admixture includes a di(organo)polysiloxane that includes at least two vinylic groups and has a viscosity of at least 100 cP at 25° C.; a silicone resin; an (organo)(hydrogen)polysiloxane; an organoplatinum polymerization catalyst; a silanated fumed silica; a polymerization retardant; an inorganic pigment; and a filler.

Abstract: A thermoplastic polymeric composition having a xanthene or xanthenes-based compound as a plasticizer, a method to modify the thermoplastic polymeric materials to increase their relative plasticity while maintaining good strength or “toughness” characteristics, and various articles of manufacture that can be made using the polymer composition are described.

Abstract: A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.

Abstract: One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m?3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer.

Abstract: The present invention relates to a compound of formula (I) wherein R1, R2 each independently of the other are identical or different organic radicals which do not contain Zerewitinoff-active hydrogen, and R4, R5, R6 each independently of the others are saturated, linear or branched organic radicals which do not contain Zerewitinoff-active hydrogen and which are also optionally substituted in the chain by heteroatoms, for use in a polyurea system which is provided in particular for sealing, bonding, gluing or covering cell tissue. The invention further provides a polyurea system comprising the compound according to the invention, and a metering system for the polyurea system according to the invention.

Abstract: The invention relates to a dental composition having a) compound (A) with the following features: only one backbone unit (U) with 6 to 20 carbon atoms, at least 6 carbon atoms thereof forming an aromatic or an aliphatic cyclic moiety, the remaining carbon atoms either being part of substituents pending from the cyclic moiety or being part of bridging groups to spacer units, wherein one or more of the remaining carbon atoms can be replaced by an oxygen atom, the backbone unit not comprising a bisphenol structure, one or two spacer unit(s) (S) being connected to the backbone unit (U) via an ether linkage, at least one spacer unit (S) having a —CH2-CH2-CH2-CH2-O—CH2-CH(Q)-OG chain or a —CH2-CH(OG)-CH2-OM residue or a mixture of these two types of spacers within one spacer unit, with G having at least one group selected from acroyl, methacroyl, acetyl, benzoyl, and combinations thereof, M having at least one aryl group, and combinations thereof, Q having at least one group selected from hydrogen, methyl, phenyl,

Abstract: A biocompatible tissue-bonding adhesive composition having a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N?1)% of the solution having free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.

Abstract: The present invention provides a medical adhesive composition containing poly-gamma-glutamic acid or its salt; and sugar or sugar alcohol, which is edible, water-soluble, anionic and biodegradable. The invention also provides a thickener composition containing poly-gamma-glutamic acid, which can be used as a moisture-absorbing agent, a moisturizing agent and a raw material for cosmetic products.

Abstract: Presently described are polymerizable ionic liquids comprising a cation and an aromatic carboxylate anion; wherein the cation, anion, or both comprise a free-radically polymerizable group. Also described are curable compositions comprising such polymerizable ionic liquids and at least one other free-radically polymerizable monomer, oligomer, or polymer.

Abstract: A high swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring high swell and slow degradation, for example, tissue augmentation, both cosmetic and reconstructive; void filling; tissue bulking, for example treatment of urinary incontinence and acid reflux; and embolization. The high swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.

Abstract: Dental composition comprising an aqueous mixture containing (i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10; R1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C1-6 alkyl group or an acyl group; L represents an (a+b)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group; b is an integer of from 1 to 10; R2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R1 wherein b is 1; provided that

Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.