Abstract: Etching compositions, curable compositions, packaged products and methods of use for the treatment of bone substrate, i.e., teeth, are described. The etch compositions generally include a gelling agent, an inorganic acid, an organic acid and either a solvent, a surfactant or mixtures thereof. The curable composites include reactive monomers and crosslinking agents that are effective to adhere to the surface of the treated substrate. The methods of the invention provide the ability to modify a bone or bone-like surface so that the curable composition, such as an adhesive resin, can be used in combination with a restorative material.

Abstract: A reaction-curable adhesive composition exhibiting acidity is formed form a weakly acidic to alkaline composition (I) comprising (a) a polymerizable monomer and (b) a compound represented by the following formula (1) and a strongly acidic composition (II) comprising (a) a polymerizable monomer. R1—C6H4—NR2CH2COOR3??(1) wherein R1 and R2 are each independently a hydrogen atom or an alkyl group which may have a functional group, and R3 is a hydrogen atom or a metal atom. The composition containing the polymerizable monomer can be stably stored for a long period of time.

Abstract: A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.

Abstract: A one-component self-etching self-priming dental adhesive composition is disclosed. The composition comprises glycerol phosphate di(meth)acrylate monomer, at least one mono-functional polymerizable monomer having just one ethylenically unsaturated group, at least one multi-functional polymerizable monomer having at least two ethylenically unsaturated groups, at least one aprotic solvent, at least one protic solvent, and at least one polymerization initiator.

Abstract: The invention relates to a dental composition comprising a) halogenated aryl alkyl ether component (A) comprising at least 1 aryl alkyl ether moiety, at least 1 halogen atom attached to each aryl residue of the aryl alkyl ether moieties, at least 2 unsaturated moieties, b) Si—H functional component (B), c) initiator (C), d) optionally filler (D), and e) optionally component (E) selected from modifiers, dyes, pigments, thixotropic agents, flow improvers, polymeric thickness, surfactants, odorous substances, diluting agent(s) and flavourings.

Abstract: The invention provides a divided type dental polymeric core build-up material including a first paste (A) and a second paste (B), in which each of the pastes is a paste obtained by mixing at least a (meth)acrylate monomer, a filler having a particle size distribution within a range of 0.1 through 40 ?m and an average particle diameter of 0.7 through 10 ?m, and a fine particle filler having an average particle diameter of primary particles of 0.001 through 0.050 ?m, and having a viscosity at 25° C. of 280 through 470 P, and in which one of the pastes includes an oxidant and the other includes a reductant and at least one of the pastes includes a photopolymerization catalyst. The divided type dental polymeric core build-up material of this invention has high operability in core build-up and forms a polymerically cured substance with a good mechanical property.

Abstract: To provide a dental alginate impression material composition capable of solving a problem that the permeation rate of water with respect to the whole powder of an alginate impression material is slow at the time of use so that a kneading time is long and a sufficient operational time cannot be secured, and a problem that a kneaded material drops into a throat due to aging of the material at the time of taking an impression, the dental alginate impression material composition comprises 0.001 to 1% by weight of one or more kinds selected from oils mainly consisting of a fatty acid and an ester of alcohol, waxes mainly consisting of a fatty acid and an ester of glycerin, and a fatty acid ester; 0.01 to 10% by weight of a surfactant; and 0.01 to 10% by weight of one or more kinds of specific polysaccharides.

Abstract: The invention provides a dental coating kit with high adhesiveness to teeth that contains a primer composition including an acidic group-containing polymeric monomer (a), water (b) and a water-soluble solvent (c) and a surface smoothing composition including a polyfunctional polymeric monomer (f), a volatile solvent (g) and a photopolymerization initiator (h); and a dental coating kit with high adhesiveness to teeth and minimally suffering from chipping and peeling off that contains a primer composition including an acidic group-containing polymeric monomer (a), water (b) and a water-soluble solvent (c), a coating composition including a polymeric monomer (d) and a photopolymerization initiator (e), and a surface smoothing composition including a polyfunctional polymeric monomer (f), a volatile solvent (g) and a photopolymerization initiator (h). Either dental coating kit is particularly useful as a kit for preventing stain and color return of a bleached tooth.

Abstract: The present invention is directed to curable cyanoacrylate-based formulation containing a multi-functional amine initiator. A dual function amine, particularly Quadrol, provides a highly desirable balance of maximum cure temperature and setting time of cure with the same higher viscosity, non-running cyanoacrylate formulation. The present invention is also directed to systems that utilize the inventive formulations and methods for use of such formulations.

Abstract: The present invention relates to processes of making a cured dental adhesive compositions, in contact with a wetting material surface, by contacting the wetting material surface having water present on the surface with a nonaqueous composition including at least one liquid radical polymeric monomer (a), an organic peroxide (b), and a water-soluble reducing compound (c) in the form of a solid, where the water-soluble reducing compound (c) is dispersed in the liquid radical polymeric monomer (a); and solvating the water-soluble reducing compound (c) present at an interface between the redox-curing nonaqueous curable composition and the wetting material with the water present on the wetting material surface.

Abstract: The invention relates to an adhesion-promoter composition for the adhesive joining of metallic or ceramic dental materials to radically curing dental materials, wherein the adhesion-promoter composition contains an alkoxysilane monomer (i), a phosphoric acid ester monomer (ii), a sulphur-containing monomer (iii) and an organic solvent (iv).

Abstract: To provide a dental adhesive composition which does not decrease preservation stability when reacting with acidity for acquiring dental adhesive property, even though using a filler having X-ray imaging property, and does not need the conventional mixing and kneading of two or more components, the dental adhesive composition includes (a) a (meth)acrylate compound having an acid group, and (b) aluminosilicate glass powder containing Sr and/or Ba and/or Ca, and the dental adhesive composition further includes a filler and (c) a photopolymerization catalyst, where the filler does not substantially make a neutralization reaction with the (meth)acrylate compound having an acid group as the (a) component because a filler content is 15% by weight or less in terms of oxide of Al2O3, and those coexist is one.

Abstract: The liquid, polymer-containing coating materials of this invention comprise a polymer of a polymerizable, nitrogen-containing, hydrophilic monomer, which may give thermoresponsive properties, and which is copolymerized with a hydrophobic, polymerizable siloxy-containing monomer, in a solvent system of a volatile hydrophobic (non-polar) liquid that is non-stinging to a user. The material forms a coating or bandage in the form of a film when applied to a surface or the skin of a user.

Abstract: Three part bonding compositions that include an etching solution, a preparative solution, and a curable composition, as well as packaged products and methods of use for the treatment of bone substrate, i.e., teeth, are described. The etch solutions generally include an inorganic acid, an organic acid, an ethylenically unsaturated functional monomer and, optionally a solvent, and water. The preparative solutions generally include an ethylenically unsaturated functional monomer, at least one polyethylenically unsaturated functional crosslinking monomer, a photo initiator, and at least one solvent. The curable composites include reactive monomers and crosslinking agents that are effective to adhere to the surface of the treated substrate. The methods of the invention provide the ability to modify a bone or bone-like surface so that the curable composition, such as an adhesive resin, can be used in combination with a restorative material.

Abstract: An object of the present invention is to provide a one-pack type dental adhesive composition which can exhibit excellent adhesion to any material, for example, dental ceramics, organic composites containing inorganic compounds, dental noble metals and dental non-noble metals, and also has excellent storage stability. Disclosed is a one-pack type dental adhesive composition comprising a silane coupling agent as a component (a), an acidic group-containing polymerizable monomer as a component (b), a sulfur atom-containing polymerizable monomer as a component (d), and other components.

Abstract: Hardenable and hardened dental compositions, and articles including such hardenable and hardened compositions, are provided. In some embodiments, the hardenable dental compositions include an acid-generating component and an acid-reactive component including one or more acid-reactive groups. Upon irradiating, and optionally heating, the hardened compositions are useful, for example, for reducing the bond strength of orthodontic appliances adhered to tooth structures with the hardened compositions.

Abstract: A non-biodegradable endodontic sealant composition comprises the reaction product of a first paste and a second paste. Either paste or both pastes include one or more of: unmodified HEMA and bioglass. The first paste includes a first polymerizing agent and the second paste includes a second polymerizing agent. A method for making the composition comprises preparing the first paste and second paste and combining the pastes under conditions to achieve a polymerization reaction initiated by a reaction between the polymerizing agents. The combining step is performed under conditions for achieving a setting time that is in a range of about 1 minute to about 1 hour. A method for treating humans having a voided region into which no re-growth will occur comprises administering the composition to the affected area, preferably to an area where tissue, tooth, or bone are not intended to re-grow.

Abstract: This invention describes an adhesive used for bonding dental and medical biomaterials to hard tissues via a molecular bridge formed from calcium-reactive amines and acrylic or methacrylic ester monomers to hard tissues such as enamel, dentin, and bone. This formulation consists of an acid-stable polymerizable compound with multi-functional acrylate cross-linkers. This formula provides good self-adherence without prior preparation of the hard tissue substrates. The formulation can contain chemical- and/or light-activated free-radical initiators.

Abstract: The invention relates to a dental composition comprising a monomer or mixture of monomers represented by the following structure (1) with 1,2R independently selected from H, alkyl (e.g. CH3C2H5), and Phenyl, 3,4R independently selected from H, alkyl (e.g. CH3), and halogen (Cl, Br, F), 5R independently selected from H, alkyl (e.g. CH3), m, n=1, 2 and x+y=2 to 10, with the proviso that if m=n=2, than x+y=2 and if m=n=1, than x+y=4 to 10. The invention also relates to a process for producing the monomer or mixture of monomers and the use thereof especially as dental composition.

Abstract: According to one embodiment of the present invention, there is provided a polyacrylamide or derivative thereof, such as poly-N-isopropyl acrylamide (pNIPAM) for use in the closure of wounds. Also provided is a composition comprising a polyacrylamide or derivative thereof in an amount effective for closing a wound, at least in part, and one or more pharmaceutically acceptable carriers. The a polyacrylamide or derivative thereof may be used in the composition according to the invention in various concentrations and may be combined with other therapeutic compounds. In another embodiment, a method for treating a wound with the compounds and compositions described herein is provided. The method comprises administering to a mammal a polyacrylamide or derivative thereof in an amount effective to close at least a part of a wound.

Abstract: This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N—Cl and/or N—Br bond.

Abstract: A one-component self-etching self-priming dental adhesive composition is disclosed. The composition comprises glycerol phosphate di(meth)acrylate monomer, at least one mono-functional polymerizable monomer having just one ethylenically unsaturated group, at least one multi-functional polymerizable monomer having at least two ethylenically unsaturated groups, at least one aprotic solvent, at least one protic solvent, and at least one polymerization initiator.

Abstract: The present invention discloses an adhesive for orthodontic attachments, which contains (A) a polymerizable monomer, (B) a polymerization initiator and (C) a fluorescent dye and, when cured, exhibits a fluorescence spectrum having a peak at 400 to 800 nm. As the polymerization initiator (B), there is preferably used a compound which generates a radical through the transfer of hydrogen between two components, or a compound which generates a radical species through intramolecular cleavage. As the fluorescent dye (C), a coumarin type dye is used preferably.

Abstract: In a synthetic board, includes a fibrous lignocellulose-based material, a resinous material and a micro hollow material. The lignocellulose-based material has an average fiber length ranging from 0.05 mm to 300 mm and an average fiber width ranging from 0.05 mm to 2 mm. The resinous material includes at least one of polybutylene succinate-based resin and polylactic-based resin. The micro hollow material has an average particle size ranging from 1 ?m to 3000 ?m.

Abstract: Dental adhesive composition having a pH of at least 5, which comprises an aqueous solution containing (a) a polymerizable N-substituted alkyl acrylic or acrylic acid amide monomer; (b) a water-soluble polymerizable carboxylic acid; and (c) a water-soluble organic solvent.

Abstract: Lactam polymers has been modified with sodium borohydride (NaBH4) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.

Abstract: An aqueous one-pack self-etching and self-priming dental adhesive composition having a pH of at most 2, which comprises: (i) a polymerizable N-substituted alkylacrylic or acrylic acid amide monomer which optionally contains an inorganic acidic moiety selected from a phosphonic acid moiety or a sulfonic acid moiety, and (ii) a curing system.

Abstract: A composition of matter for increasing the relative flexibility and plasticity of crystalline or semi-crystalline resins and polymers is described. In particular, the compositions include xanthene or anthene-based molecular structures that can increase the plastic properties of curable resins or thermosetting polymers when incorporated into the polymer material. Certain uses for such a polymeric composition are also provided.

Abstract: A novel environmentally responsive polymeric system is provided for biomedical applications, comprising silicon-containing reactive groups which undergo a hydrolysis-condensation reaction at a predetermined body site and thereby change rheological and mechanical properties of the polymeric system. The polymeric system is useful, for example, as a sealant, as a matrix for drug delivery, in the prevention of post-surgical adhesions, and in gene therapy.

Abstract: Polymerizable dental material which contains at least one radically-polymerizable monomer and at least one bisacylphosphine oxide of the Formula I, in which R1 is a linear or branched C2 to C14 alkyl residue, which can be interrupted by one or more O atoms, PG-Y—R2—X— or a substituted or unsubstituted, aromatic C6 to C14 radical; R2 is absent or a linear or branched C1 to C20 alkylene radical, which can be interrupted by one or more O atoms; R3 is H, a linear or branched C1 to C6 alkyl residue or PG-Y—R2—X—; R4 is a linear or branched C1-C6 alkyl or —O—C1-C6 alkyl residue; R5 is H or PG-Y—R2—X—; R6 is H or PG-Y—R213 X—; PG is a polymerizable group; X is absent, O or S; Y is absent, O, S, an ester, amide or urethane group; the bisacylphosphine oxide having at least one PG-Y—R2—X group and X and/or Y being absent if R2 is absent.

Abstract: A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.

Abstract: A composition is disclosed comprising a polymerizable (meth)acrylate of the structure: wherein A is an anhydride; a is 0 or 1; n is 0, 1, 2, or 3; R1, R2, R3, and R4 are each independently hydrogen, hydroxy, C1-C12 alkyl, C1-C12 perhaloalkyl, C1-C12 alkoxy, C1-C12 perhaloalkoxy, C2-C12 alkenyl, C2-C12 alkynyl, (C1-C6 alkyl)-O-(C1-C6 alkylene), or hydroxy(C1-C6 alkylene); x and y are each independently an integer of 1 to 10; z is an integer of 1 to 5; R5 is hydrogen or methyl; M is wherein G and J are each independently O or NR6, wherein R6 is hydrogen or C1-C6 alkyl; m is 1, 2, 3, or 4; W is an organic group having the valency of z+1; and q is 0 or 1; and further wherein when a is 1, n+m+q is 1, 2, 3, or 4, and when a is 0, n+m+q is 1, 2, 3, 4, 5, or 6. The composition finds use as a dental resin.

Abstract: The invention relates to adhesive compositions that exhibit a significant decrease in polarity upon polymerization. More specifically, it relates to curable self etching dental adhesive compositions that can be applied to the tooth hard substance in one step and exhibit this decrease in polarity upon curing. In this respect a formulation is provided combining phosphoric acid esters bearing substituents with one ethylenically unsaturated moiety on the phosphorus atom and phosphoric acid esters bearing substituents with two or more ethylenically unsaturated moieties on the phosphorus atom.

Abstract: The present invention is directed to dental compositions that can be used as adhesives for bonding a dental material to a dental structure surface and/or as a dental restorative material. The dental composition is preferably applied to a dental structure surface under conditions effective to etch the dental structure surface.

Abstract: The invention relates to compositions, polymerizable by ring-opening metathesis, which contain (a) at least one monomer and/or oligomer which is polymerizable by ring-opening metathesis polymerization, (b) at least one filler and (c) at least one initiator for the ring-opening metathesis polymerization. The compositions are characterized in that the initiator is chemically or physically bound to the filler.

Abstract: A dental polymerizable composition comprising (a) a fluorine compound comprising a chain polymer having a main chain comprising a monomer unit having a hydrophilic group, and terminal groups comprising a fluoroalkyl group at each of both ends of the main chain; (b) a polymerizable monomer; and (c) a polymerization initiator.

Abstract: A dental material primer and a dentin-regenerating pulp-capping agent which exhibit an excellent dentin-regenerating action, are disclosed. The dental material primer includes a hydrolyzed ethylene-vinyl acetate copolymer in which collagen is immobilized and the dentin-regenerating pulp-capping agent includes a hydrolyzed ethylene-vinyl acetate copolymer, in which collagen is immobilized, and a binder.

Abstract: A dental self-etching primer composition and a dental self-etching primer kit comprising a mixture of (A) a polymerizable monomer, (B) a reducing inorganic compound containing sulfur, (C) a ketone-based solvent and (D) water and having a storage stability of 2 hours or longer at 65° C.

Abstract: The present invention provides a one-component dental adhesive composition which can exhibit excellent adhesion to both materials of a dental ceramics and an organic composite containing an inorganic compound, and is excellent in can-stability. More particularly, the present invention provides a one-component dental adhesive composition comprising 1 to 60 parts by weight of (a) a silane coupling agent, 1.0 to 20.0 parts by weight based on 100 parts by weight of the (a) component of (b) an acidic group-containing polymerizable monomer, and 28 to 99 parts by weight of (c) a volatile organic solvent.

Abstract: Three part bonding compositions that include an etching solution, a preparative solution, and a curable composition, as well as packaged products and methods of use for the treatment of bone substrate, i.e., teeth, are described. The etch solutions generally include an inorganic acid, an organic acid, an ethylenically unsaturated functional monomer and, optionally a solvent, and water. The preparative solutions generally include an ethylenically unsaturated functional monomer, at least one polyethylenically unsaturated functional crosslinking monomer, a photo initiator, and at least one solvent. The curable composites include reactive monomers and crosslinking agents that are effective to adhere to the surface of the treated substrate. The methods of the invention provide the ability to modify a bone or bone-like surface so that the curable composition, such as an adhesive resin, can be used in combination with a restorative material.

Abstract: Polymerizable dental material, characterized in that it contains at least one (meth)acrylamide phosphate of the following general formula (I): in which R1 is H or CH3; R2 is H or a C1-C4 alkyl radical or forms together with the nitrogen atom to which it is bonded and one or more atoms which belong to R3 or R3? a heterocyclic ring; R3, R3? independently of each other are a linear or branched aliphatic C1-C50 radical with a valency of m+n or p+n, an aromatic C6-C18 radical with a valency of m+n or p+n, or a cycloaliphatic, araliphatic or heterocyclic C3-C18 radical with a valency of m+n or p+n, wherein the carbon chains of the radical or radicals can be interrupted by O, S, CONR4, OCONH, or form together with one or more atoms which belong to R2 and the nitrogen atom, to which the R2 is bonded a heterocyclic ring, R3? being H if p=0, and R4 being H, C1-C10 alkyl, C6-C12 aryl, C6-C10 aralkyl or a bicyclic C4-C12 radical; n is 1, 2, 3 or 4 if p=0, and is 1 or 2 if p?0; m is 1, 2, 3 or 4; p is 0, 1, 2, 3 or 4;

Abstract: The invention relates to a dental composition comprising a) carbosilane containing component (A) comprising at least 1 Si-Aryl bond, at least 1 silicon atom, at least 2 unsaturated moiety, no Si—Oxygen bond, b) Si—H functional component (B), c) initiator (C), d) optionally filler (D), and e) optionally component (E) selected from modifiers, dyes, pigments, thixotropic agents, flow improvers, polymeric thickeners, surfactants, odorous substances, diluting agent(s) and flavorings.

Abstract: Dental materials which contain a radically polymerizable organic binder, at least one radical polymerization initiator and at least one radical polymerization accelerator, both the initiator and the accelerator each having at least one radically polymerizable group.

Abstract: The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided.

Abstract: Dental composition comprising an aqueous mixture containing (i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10; R1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C1-6 alkyl group or an acyl group; L represents an (a+b)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group; b is an integer of from 1 to 10; R2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R1 wherein b is 1; provided that

Abstract: A high swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring high swell and slow degradation, for example, tissue augmentation, both cosmetic and reconstructive; void filling; tissue bulking, for example treatment of urinary incontinence and acid reflux; and embolization. The high swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.

Abstract: The present invention features ionomer compositions containing nanozirconia fillers. The compositions can be used in a variety of dental and orthodontic applications, for example, as adhesives, cements, restoratives, coatings and sealants.

Abstract: Biologically compatible polymers carry at least two different kinds of functional groups. Adhesive formulations include a biologically compatible adhesive, which can be used with a bridging molecule.

Abstract: A polymerizable adhesive composition comprises at least one ?-cyanoacrylate monomer and at least one absorbable viscosity modifying agent. The absorbable viscosity modifying agent has repeated units of the following structure: R1 is a methyl group or a hydrogen. R2 is a straight, branched or cyclic alkyl group having from 1 to 6 carbon atoms. R3 is a straight, branched or cyclic alkyl group having from 1 to 12 carbon atoms, and n is 2 or more.

Abstract: The present application provides dental compositions, and methods of making and using dental compositions that include a calcium and phosphorus releasing glass. Such dental compositions can be useful for delivering ions to the oral environment.