Ethers Patents (Class 536/120)
  • Patent number: 10413566
    Abstract: A method of treatment includes agitating a thixotropic oxidized cellulose solution; administering the agitated thixotropic oxidized cellulose solution to a target tissue site; and allowing the agitated thixotropic oxidized cellulose solution to gel at the target tissue site.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: September 17, 2019
    Assignee: Covidien LP
    Inventors: Rachit Ohri, Phillip D. Blaskovich
  • Patent number: 10307627
    Abstract: The invention relates to fire-extinguishing foams or concentrates, which include a carbohydrate containing silane surfactant.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: June 4, 2019
    Assignee: UNIVERSITÄT ZU KÖLN
    Inventors: Dirk Blunk, Ralf Helmut Hetzer, Richard Daniel Matthias Meisenheimer, Kai Oliver Wirz
  • Patent number: 10125079
    Abstract: Unique methods have been developed to convert polysaccharides into value-added products, such as levulinic acid and alkyl levulinates. The polysaccharides are heated in the presence of water, an alcohol, and an acid to cleave the polysaccharide, and the resulting monosacchrides or monosaccharide acetals or both are contacted with an acid in the presence of an alcohol at a higher temperature. Useful acids include Brønsted acid catalysts and Lewis acid catalysts including mineral acids, metal halides, immobilized heterogeneous catalysts functionalized with a Brønsted acid group or a Lewis acid group, or combinations thereof.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: November 13, 2018
    Assignee: Battelle Memorial Institute
    Inventors: Herman P. Benecke, Daniel B. Garbark
  • Patent number: 10053543
    Abstract: Organopolysiloxane gel compositions containing an organopolysiloxane gel produced by hydrosilylation of an unsaturated silicone resin and a compound containing glycoside residues and a hydrosilylatable group with at least one Si—H-functional organopolysiloxane can form creamy, storage-stable gels which are capable of containing large amounts of polar or hydrophilic substances such as water and glycerol while remaining monophasic. The compositions are especially useful in providing cosmetic compositions with a silky skinfeel.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: August 21, 2018
    Assignee: WACKER CHEMIE AG
    Inventor: Sebastian Knoer
  • Patent number: 9758619
    Abstract: Ethylene carbonate is polymerized by itself or together with another cyclic monomer such as 1,2-propylene oxide in the presence of a double metal cyanide catalyst. Most of the ethylene carbonate adds to the chain to form a terminal carbonate group, which decarboxylates to produce a hydroxyethyl group at the end of the polymer chain. The polymerization of more ethylene carbonate onto the chain end results in the formation of poly(ethyleneoxy) units. Therefore, the process provides a method for making poly(ethyleneoxy) polymers without the need to polymerize ethylene oxide. The process is useful for making polyethers that are useful as water-absorbable polymers, surfactants and as raw materials for polyurethanes. The process is also useful for increasing the primary hydroxyl content of a polyether.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: September 12, 2017
    Assignee: Dow Global Technologies LLC
    Inventors: Esther E. Quintanilla, Hanno R. Van Der Wal, Daniel C. Floyd, Myriam Linke, Francois M. Casati, Carlos M. Villa, Jean-Paul Masy, Ricco B. Borella, Paul Cookson
  • Patent number: 9611255
    Abstract: The present invention relates to the a process for total synthesis of flavonoid compounds of general formula I and isomers thereof wherein R1 and R2 is OH; R3?H or The present invention particularly relates to the process for preparation and separation of (2S,3S)-taxifolin-6-C-?-D-glucopyranoside (ulmoside A), (2R,3R)-taxifolin-6-C-?-D-glucopyranoside and taxifolin.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 4, 2017
    Assignee: Council of Scientific and Industrial Research
    Inventors: Batchu Venkateswara Rao, Macha Lingamurthy, Gurrapu Raju, Vanka Umamaheswara Sarma
  • Patent number: 9499575
    Abstract: The present invention provides carbohydrate-based surfactants and methods for producing the same. Methods for producing carbohydrate-based surfactants include using a glycosylation promoter to link a carbohydrate or its derivative to a hydrophobic compound.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: November 22, 2016
    Assignee: The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Jeanne E. Pemberton, Robin L. Polt, Raina M. Maier, Clifford S. Coss
  • Patent number: 9441051
    Abstract: The present invention discloses a matrix comprising a modified primary hydroxyl groups containing polysaccharide comprising repeating disaccharide units wherein in at least part of the disaccharide units the primary hydroxyl group is replaced by functional groups selected from halide groups or groups comprising sulfur or phosphorus atoms, like e.g. sulfate groups, sulfonate groups, phosphonate groups and phosphate groups.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: September 13, 2016
    Assignee: ALBERT LUDWIGS UNIVERSITÄFREIBURG
    Inventors: V. Prasad Shastri, Aurelien Forget, Florian Mieβmer
  • Patent number: 9434789
    Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (?5 mm) and a high molecular weight polymer (?1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: September 6, 2016
    Assignee: ACCESS MEDICAL SYSTEMS, LTD.
    Inventor: Robert F. Zuk
  • Patent number: 9102965
    Abstract: A saccharide-solution producing apparatus 11A according to the present invention is a saccharide-solution producing apparatus for producing a saccharide solution 22 derived from a carbohydrate-based material 21, and includes a saccharide-solution controlling unit 15A that controls the saccharide solution derived from the carbohydrate-based material 21, a cellulosic biomass saccharifying unit 16 that saccharifies hydrothermally treated biomass obtained by hydrothermally decomposing a cellulosic biomass material 35 that contains a lignin component and a hemicellulose component, and produces a diluted saccharide solution 37, and a diluted-saccharide-solution supply pipe L11 that mixes the diluted saccharide solution 37 produced by the cellulosic biomass saccharifying unit 16 into the saccharide-solution controlling unit 15A. With this configuration, it is possible to improve production efficiency of the saccharide solution 22 and to realize cost reduction.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: August 11, 2015
    Assignee: MITSUBISHI HEAVY INDUSTRIES MECHATRONICS SYSTEMS, LTD.
    Inventors: Minoru Genta, Seiichi Terakura, Hideo Suzuki, Gaku Kondo, Michio Nishiyama
  • Patent number: 9074232
    Abstract: A saccharide-solution producing apparatus 11A according to the present invention is a saccharide-solution producing apparatus for producing a saccharide solution 22 derived from a carbohydrate-based material 21, and includes a saccharide-solution controlling unit 15A that controls the saccharide solution derived from the carbohydrate-based material 21, a cellulosic biomass saccharifying unit 16 that saccharifies hydrothermally treated biomass obtained by hydrothermally decomposing a cellulosic biomass material 35 that contains a lignin component and a hemicellulose component, and produces a diluted saccharide solution 37, and a diluted-saccharide-solution supply pipe L11 that mixes the diluted saccharide solution 37 produced by the cellulosic biomass saccharifying unit 16 into the saccharide-solution controlling unit 15A. With this configuration, it is possible to improve production efficiency of the saccharide solution 22 and to realize cost reduction.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: July 7, 2015
    Assignee: MITSUBISHI HEAVY INDUSTRIES MECHATRONICS SYSTEMS, LTD.
    Inventors: Minoru Genta, Seiichi Terakura, Hideo Suzuki, Gaku Kondo, Michio Nishiyama
  • Patent number: 9012413
    Abstract: The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R2 is an OSO3? or hydroxyl group, R3 is an alkyl, cycloalkyl, or alkyl-cycloalkyl group, R4 is a disaccharide having Formula (II), R6 is a disaccharide having Formula (III), and R8 is a disaccharide having Formula (IV), where R5, R7, and R9 are OSO3? or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: April 21, 2015
    Assignee: Sanofi
    Inventors: Pierre Alexandre Driguez, Philippe Duchaussoy, Pierre Fons, Corentin Herbert, Gilbert Lassalle
  • Publication number: 20150080220
    Abstract: Compositions including a highly branched alpha-D-glucan or modified forms thereof and a solute compound are described herein. The compositions can provide increased water solubility and/or increased rate of dissolution for the solute compound. The compositions can also provide increased stability for the solute compound. Methods for preparing and using compositions including a solute compound and a highly branched alpha-D-glucan are also described.
    Type: Application
    Filed: April 19, 2013
    Publication date: March 19, 2015
    Inventors: Yuan Yao, Jingmin Zhang
  • Publication number: 20150065702
    Abstract: 3-O-Fucosyllactose is made by process which includes the hydrogenolysis of a new compound of the formula 1 wherein R1 and R2 are independently a group removable by hydrogenolysis, and R3 is a group removable by hydrogenolysis or H; or a hydrate or solvate thereof.
    Type: Application
    Filed: March 20, 2013
    Publication date: March 5, 2015
    Inventors: Christoph Röhrig, Gyula Dekany, Martin Matwiejuk, Sándor Demkó
  • Patent number: 8962823
    Abstract: This invention concerns the first environmentally benign heterogeneous modification of polysaccharide-based material in native solid state by thiol-ene “click chemistry”. The direct reaction of a thiol with an un-activated double or triple bond by thiol-ene and thiol-enyne click modification is thermally or photochemically catalyzed and is completely metal-free and allows for a highly modular approach to modifications of fibers and fiber-based materials.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: February 24, 2015
    Assignee: Organoclick AB
    Inventors: Armando Cordova, Jonas Hafren
  • Publication number: 20150025023
    Abstract: The invention provides a method for preparing sulphoalkyl ether-?-cyclodextrin. The method comprises first contacting cyclodextrin with a base to form activated cyclodextrin. The method then comprises separately contacting the activated cyclodextrin with an alkyl sultone to form sulphoalkyl ether-?-cyclodextrin. The activation reaction is carried in batch and the sulphoalkylation reaction is carried out under continuous flow conditions.
    Type: Application
    Filed: July 16, 2014
    Publication date: January 22, 2015
    Inventors: Tammy Savage, Stephen Wicks, John Mitchell
  • Publication number: 20150025157
    Abstract: There is provided a novel gelator containing a sugar derivative. A gelator including a compound of Formula (1) or Formula (2): wherein each of R1 and R3 is independently a linear or branched alkyl group having a carbon atom number of 1 to 20, a cyclic C3-20 alkyl group, or a linear or branched alkenyl group having a carbon atom number of 2 to 20, n is 0 or an integer of 1 to 4, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R4 and R5 are each a hydroxy group.
    Type: Application
    Filed: March 8, 2013
    Publication date: January 22, 2015
    Inventors: Fumiyasu Ono, Seiji Shinkai, Osamu Hirata
  • Patent number: 8927698
    Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: January 6, 2015
    Assignee: Glycom A/S
    Inventors: Gyula Dékany, Istvan Bajza, Julien Boutet, Ignacio Pérez Figueroa, Markus Hederos, Ferenc Horvath, Piroska Kovács-Pénzes, Lars Kröger, Johan Olsson, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas
  • Patent number: 8912168
    Abstract: A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: December 16, 2014
    Inventor: Xin Ji
  • Patent number: 8900706
    Abstract: A process for producing cellulose nanocrystals (CNCs) involves providing a cellulosic material, contacting the cellulosic material with an inorganic persulfate at an elevated temperature to produce CNCs, and recovering the CNCs. The process permits one-step production of CNCs from vegetative biomasses such as flax and hemp. Cellulose nanocrystals produced by the process with carboxylic groups are more uniform and have higher aspect ratios than CNCs produced by prior art processes.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: December 2, 2014
    Assignee: National Research Council of Canada
    Inventors: Chi Woon Leung, John H. T. Luong, Sabahudin Hrapovic, Edmond Lam, Yali Liu, Keith B. Male, Khaled Mahmoud, Denis Rho
  • Publication number: 20140343010
    Abstract: The present invention provides novel co-crystal forms of dapagliflozin, namely a dapagliflozin lactose co-crystal and a dapagliflozin asparagine co-crystal, to pharmaceutical compositions comprising same, methods for their preparation and uses thereof for treating type 2 diabetes.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 20, 2014
    Applicant: MAPI PHARMA LTD.
    Inventors: Ehud MAROM, Shai RUBNOV
  • Publication number: 20140323417
    Abstract: A crystalline dapagliflozin hydrate and a process for obtaining the same is described.
    Type: Application
    Filed: November 28, 2012
    Publication date: October 30, 2014
    Inventors: Fritz Blatter, Katharina Reichenbaecher
  • Patent number: 8846901
    Abstract: A particulate SAE-CD composition is provided. The SAE-CD composition has an advantageous combination of physical properties not found in known solid forms of SAE-CD. In particular, the SAE-CD composition possesses an advantageous physicochemical and morphological property profile such that it can be tailored to particular uses. The SAE-CD composition of the invention has improved flow and dissolution performance as compared to known compositions of SAE-CD.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 30, 2014
    Assignee: Cydex Pharmaceuticals, Inc.
    Inventors: Gerold L. Mosher, James D. Pipkin, Douglas B. Hecker
  • Publication number: 20140243517
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 28, 2014
    Applicant: AstraZeneca AB
    Inventors: Prashant P. Deshpande, Bruce A. Ellsworth, Janak Singh, Theodor W. Denzel, Chiajen Lai, Gerard Crispino, Michael E. Randazzo, Jack Z. Gougoutas
  • Publication number: 20140243283
    Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.
    Type: Application
    Filed: December 18, 2013
    Publication date: August 28, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Yeeman K. Ramtohul, Sanjoy Kumar Das, Caroline Cadilhac, Thumkunta Jagadeeswar Reddy, Louis Vaillancourt, Michel Gallant, Bingcan Liu, Evelyne Dietrich, Frederic Vallee, Julien Martel, Carl Poisson
  • Patent number: 8802637
    Abstract: Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: August 12, 2014
    Assignee: Theracos, Inc.
    Inventors: Yuanwei Chen, Huawei Cheng, Shengbin Li, Yuelin Wu, Yan Feng, Binhua Lv, Binhua Xu, Brian Seed, Michael J. Hadd, Yanli Song, Jiyan Du, Congna Wang, Jacques Y. Roberge
  • Patent number: 8791077
    Abstract: Methods are provided for treating hyperuricemia, employing an SGLT2 inhibitor alone, or in combination with a supply of carbohydrate, and/or in combination with an inhibitor of uric acid synthesis. Additionally, pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate or an inhibitor of uric acid synthesis or a supply of carbohydrate and an inhibitor of uric acid synthesis are provided in the instant invention and are provided for use in the inventive methods.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: July 29, 2014
    Assignee: AstraZeneca AB
    Inventor: Bruce Robert Leslie
  • Publication number: 20140199727
    Abstract: The present invention concerns compounds of the following formula (I) or a pharmaceutically acceptable salt thereof, a stereoisomer or a mixture of stereoisomers in any proportion, in particular a mixture of enantiomers, and particularly a racemate mixture, in which R represents H, OH or OR19, as well as processes for preparing these compounds and their use as inducer for the transcription of genes under control of the lac promoter.
    Type: Application
    Filed: August 8, 2012
    Publication date: July 17, 2014
    Applicant: TFCHEM
    Inventors: Geraldine Deliencourt-Godefroy, Hyacinthe Fillon
  • Publication number: 20140179913
    Abstract: Poly alpha-1,3-glucan ether compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing poly alpha-1,3-glucan ether compounds.
    Type: Application
    Filed: December 16, 2013
    Publication date: June 26, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: JAYME L. PAULLIN, Andrea M. Perticone, Rahul B. Kasat, T Joseph Dennes
  • Publication number: 20140161792
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 12, 2014
    Applicants: FORSCHUNGSZENTRUM BORSTEL, UNIVERSIT TSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Christian Theilacker, Zbignew Kacynski, Otto Holst
  • Publication number: 20140142292
    Abstract: A (meth)allylsilane compound chemically bonded to various alcohol derivatives including polyol derivatives such as saccharides, is raw material used to cause a substrate to express functionalities such as a defogging property and separation characteristics for column chromatography, can be easily prepared, is easily purified, and is stable and easy to handle, and a functional material in which those functionalities are expressed, while silyl group-containing groups are conveniently carried at a high density on the surface of the substrate, by using the (meth)allylsilane compound as a silane coupling agent for silane-coupling to the substrate. The (meth)allylsilane compound includes a (meth)allylsilyl group-containing alkyl group or a (meth)allylsilylalkyl group-containing aralkyl group that is bonded to an alcohol derivative.
    Type: Application
    Filed: June 28, 2012
    Publication date: May 22, 2014
    Applicants: DAICEL CORPORATION, KYOEISHA CHEMICAL CO., LTD.
    Inventor: Toyoshi Shimada
  • Publication number: 20140142296
    Abstract: The invention provides methyl-2-deoxyriboside containing at most 5 wt % of methyl-2-deoxyribopyranoside, based on the combined weight of methyl-2-deoxyriboside and methyl-2-deoxyribopyranoside.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Xing Fu, Albercht Zumbrunn
  • Patent number: 8673864
    Abstract: The present invention provides a mangiferin-berberine salt and manufacturing method thereof. Otherwise, the present invention also provides the use of mangiferin-berberine salt as AMPK activator.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: March 18, 2014
    Assignee: Hainan Deze Drug Research Co., Ltd.
    Inventors: Houlei Teng, Wei Wu
  • Publication number: 20140051648
    Abstract: Disclosed is a compound of formula I, or a pharmaceutically acceptable salt, solvate, polymorph, enantiomer or racemic mixture thereof, wherein R1 and R2 are each independently hydrogen, —OH, alkyl, —CF3, —OCHF2, —OCF3 or halogen; R3 is cycloalkyl, —OCH2CF3, —OCH2CHF2, —OCH2CH2F or —OCH2CH3; R4 is hydrogen, —OH, —O aryl, —OCH2 aryl, alkyl, cycloalkyl, —CF3, —OCHF2, —OCF3, —OCH2CF3, —OCH2CHF2, —OCH2CH2F or halogen; A is —CX1X2, wherein X1 and X2 are each independently H, F and Cl, and when both X1 and X2 are H, R3 is not —OCH2CH3. The compound has an activity of inhibitors of sodium-dependent glucose transport protein. Also disclosed is a method for preparing the compound, a pharmaceutical composition comprising the compound, use of the compound and pharmaceutical composition thereof in preparing medicaments of SGLT2 inhibitors and treating related diseases.
    Type: Application
    Filed: February 20, 2012
    Publication date: February 20, 2014
    Inventor: Michael Wang
  • Patent number: 8629266
    Abstract: Starch-based dextrin adhesive additives and methods of preparation are described. Adhesives containing the additive exhibit antimicrobial properties and increased water solubility. The additive contains at least one sugar unit, at least one polyphenol side chain, and at least one Frechet-type poly(aryl ether)dendron.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: January 14, 2014
    Assignee: Empire Technology Development LLC
    Inventor: Glen Leon Brizius
  • Patent number: 8614195
    Abstract: The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: December 24, 2013
    Assignee: Novartis AG
    Inventor: Gregory Raymond Bebernitz
  • Patent number: 8609622
    Abstract: C-aryl glucoside derivatives, preparation processes and pharmaceutical uses thereof are disclosed. In particular, C-aryl glucoside derivatives represented by formula (I), with each substituent defined in the application, pharmaceutically acceptable salts or stereoisomers thereof, their preparation methods, and pharmaceutical compositions containing the derivatives as well as their uses as therapeutic agents, particularly as sodium-dependent glucose cotransporter (SGLT)-1 inhibitors, are disclosed.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: December 17, 2013
    Assignees: Shanghai Hengrui Pharmaceutical Co., Ltd., Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Fanglong Yang, Peng Cho Tang, Qing Dong, Wangyang Tu, Jiang Fan, Dongliang Guan, Guangyuan Shen, Yang Wang, Jijun Yuan, Limin Zhang
  • Publication number: 20130324712
    Abstract: Methods for purifying and extracting compounds from a mixture are provided using a solvent-free mechanochemical method. Methods for purifying and/or extracting sugars, amino acids, and, the like, from a mixture are also provided, using a solvent-free mechanochemical method.
    Type: Application
    Filed: June 4, 2012
    Publication date: December 5, 2013
    Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventor: Mark Allan Tapsak
  • Patent number: 8592573
    Abstract: Thermoplastic heteropolysaccharide derivatives, articles employing such thermoplastic heteropolysaccharide derivatives and methods for making such thermoplastic heteropolysaccharide derivatives are provided.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: November 26, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Robert Lee Barcus, Alyssandrea Hope Hamad-Ebrahimpour, Alan Howard Ullman, Dean Van Phan, Mark Edwin Forry, John Collins Dyer, Timothy Duane Smith, Jeanette Marie Swartz, Yonas (NMN) Gizaw
  • Publication number: 20130303480
    Abstract: This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.
    Type: Application
    Filed: October 13, 2011
    Publication date: November 14, 2013
    Inventors: Kenneth N. Horne, Jayakumar Rajadas, Geoffrey C. Gurtner, Naveen Jayakumar
  • Publication number: 20130303751
    Abstract: A one or two step process for the acetylation and refining of wood pieces in which acetylation and refining to a reduced geometry take place simultaneously in the refiner. Engineered board products comprising acetylated reduced geometry materials possess high dimensional stability and durability compared to like board products comprising non-acetylated materials.
    Type: Application
    Filed: September 16, 2011
    Publication date: November 14, 2013
    Applicant: TITAN WOOD LIMITED
    Inventor: Roger M. Rowell
  • Publication number: 20130289055
    Abstract: A powder of cold-soluble polysaccharide and polyol, which is highly viscous in water and suitable for direct compression, and a method for preparing the powder and uses thereof are described, the powder being notably intended for preparing solid forms with controlled release of an active principle.
    Type: Application
    Filed: November 2, 2011
    Publication date: October 31, 2013
    Applicant: ROQUETTE FRERES
    Inventors: Baptiste Boit, Fabrice Buquet, Gregory Le Bihan, Philippe Lefevre
  • Patent number: 8569480
    Abstract: Described are a hydroxyethylstarch, a process for the preparation thereof, a pharmaceutical formulation containing such a hydroxyethylstarch, and the use of the pharmaceutical formulation for the preparation of a volume replacement, a plasma replacement or a plasma volume expander, as well as the use of the pharmaceutical formulation for maintaining normovolemia and/or for improving the macro- and microcirculation and/or for improving the nutritive oxygen supply and/or for stabilizing hemodynamics and/or for improving the volume efficiency and/or for reducing the plasma viscosity and/or for increasing anemia tolerance and/or for hemodilution, especially for therapeutic hemodilution in disturbed blood supply and arterial, especially peripheral arterial, occlusive diseases.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: October 29, 2013
    Assignee: B. Braun Melsungen AG
    Inventors: Michael Boll, Andreas Fisch, Donat R. Spahn
  • Publication number: 20130261078
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Application
    Filed: September 14, 2012
    Publication date: October 3, 2013
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Patent number: 8541571
    Abstract: The invention is directed to a simple and new method for the homogeneous synthesis of cellulose ethers. Ionic liquids are not only used as solvent, but also as reaction media for the homogeneous etherification of cellulose. The dissolved cellulose is treated with the etherification agent in the absence of organic and/or inorganic bases and in the absence and/or in the presence of moderate amounts of water. The obtained cellulose ethers show new distributions of substitution on the polymer chain, resulting in new properties and applications.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: September 24, 2013
    Assignee: SE Tylose GmbH & Co. KG
    Inventors: Eugen Moellmann, Thomas Heinze, Tim Liebert, Sarah Koehler
  • Publication number: 20130196944
    Abstract: The present invention pertains to a filler composition comprising ?-glucan moieties and optionally a cosmetically and/or pharmaceutically acceptable carrier. It further relates to a filler composition, wherein the ?-glucan moieties are cross-linked. in one embodiment of the instant invention the filler composition is a dermal filler. In one further embodiment of the present invention the filler composition is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler composition is for use in the treatment of a medical condition. The filler composition provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler composition as claimed herein.
    Type: Application
    Filed: August 17, 2011
    Publication date: August 1, 2013
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventor: Heiko Barg
  • Publication number: 20130131334
    Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates.
    Type: Application
    Filed: April 7, 2010
    Publication date: May 23, 2013
    Applicant: Glycom A/S Danmarks Tekniske Universitet
    Inventors: Gyula Dékany, Károly Ágoston, Istvan Bajza, Julien Boutet, Marie Bøjstrup, Mette Fanefjord, Ignacio Pérez Figueroa, Markus Hederos, Ference Horvath, Piroska Kovács-Pénzes, Lars Kröger, Johan Olsson, Christoph Röhrig, Andreas Schroven, Ioannis Vrasidas
  • Patent number: 8440817
    Abstract: The present invention relates to a process for efficiently producing methyl cellulose in an industrially convenient manner. The production process of the present invention includes the step of reacting cellulose with methanol in a subcritical state.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: May 14, 2013
    Assignee: Kao Corporation
    Inventor: Munehisa Okutsu
  • Patent number: 8436155
    Abstract: A 7,2?-dehydrate puerarin represented by formula (I) and salt derivatives thereof. The compounds are prepared from puerarin by intramolecular mitsunobu reaction. They are capable of shortening arrhythmia duration and prolonging coagulation time. They can be prepared into oral formulations or injections for treatment of cardiovascular and cerebrovascular diseases including arrhythmia, coronary heart disease, angina pectoris, myocardial infarction, and cerebral infarction.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: May 7, 2013
    Assignee: Shandong University
    Inventors: Hongxiang Lou, Jian Gao, Xia Xue
  • Patent number: 8410077
    Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: April 2, 2013
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventor: Vincent Antle