Polysaccharides Patents (Class 536/123.1)
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Patent number: 8586731Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.Type: GrantFiled: June 11, 2010Date of Patent: November 19, 2013Assignee: Surmodics, Inc.Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Pamela J. Reed
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Publication number: 20130303748Abstract: A method for making aldehyde-functionalized polysaccharides having pendant aldehyde groups is described. The method involves the hydroformylation of an alkene-functionalized polysaccharide. The resulting aldehyde-functionalized polysaccharides are useful for forming hydrogel tissue adhesives and sealants for medical applications.Type: ApplicationFiled: May 10, 2012Publication date: November 14, 2013Applicant: Actamax Surgical Materials, LLCInventors: Samuel D. Arthur, Steven W. Shuey, Barry M. Trost
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Publication number: 20130303480Abstract: This disclosure relates generally to soft tissue augmentation threads, methods of making such threads and uses thereof, for example, in aesthetic applications (e.g., facial contouring, soft tissue augmentation products), surgery (e.g., sutures), drug delivery, negative pressure wound therapy, moist wound dressing, and the like.Type: ApplicationFiled: October 13, 2011Publication date: November 14, 2013Inventors: Kenneth N. Horne, Jayakumar Rajadas, Geoffrey C. Gurtner, Naveen Jayakumar
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Patent number: 8580953Abstract: The present invention relates to a process for producing a water-absorbent polysaccharide including the process steps of bringing into contact an uncrosslinked polysaccharide with a polyphosphate or a polyphosphoric acid as crosslinking agent in the presence of water to form a polysaccharide gel and crosslinking the polysaccharide gel. The invention further relates to a water-absorbent polysaccharide obtainable by this process, a water-absorbent polysaccharide, a composite, a process for producing a composite, a composite produced by this process, the use of the water-absorbent polysaccharides or of the composites as well as the use of polyphosphates.Type: GrantFiled: June 20, 2005Date of Patent: November 12, 2013Assignee: Evonik Degussa GmbHInventors: Markus Frank, Frank Loeker, Dirk Paepen, Scott Smith
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Publication number: 20130295099Abstract: An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a Campylobacter organism. There is also provided an antibody or antisera against the compound, having particular use to diagnose the presence of an infection caused by a Campylobacter organism.Type: ApplicationFiled: February 11, 2011Publication date: November 7, 2013Applicant: The Governors of the University of AlbertaInventors: Christine SZYMANSKI, Harald NOTHAFT
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Publication number: 20130296543Abstract: A reactive extrusion process for the production of substituted polysaccharides, in particular, cellulose acetate, starch acetate, carboxymethyl cellulose, and carboxymethyl starch.Type: ApplicationFiled: November 8, 2011Publication date: November 7, 2013Inventors: Milford Hanna, Pratik Bhandari
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Publication number: 20130295161Abstract: The present invention is related to the field of wound healing or tissue regeneration due to disease (i.e., for example, cardiovascular diseases, osteoarthritic diseases, or diabetes). In particular, the present invention provides compositions and methods comprising molecules with linked ?-gal epitopes for induction of an inflammatory response localized within or surrounding damaged tissue. In some embodiments, the present invention provides treatments for tissue repair in normal subjects and in subjects having impaired healing capabilities, such as diabetic and aged subjects.Type: ApplicationFiled: April 2, 2013Publication date: November 7, 2013Inventor: Uri Galili
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Patent number: 8575333Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.Type: GrantFiled: September 14, 2007Date of Patent: November 5, 2013Inventor: Bahram Memarzadeh
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Patent number: 8575129Abstract: An amide of hyaluronic acid or a derivative thereof which comprises at least one repetitive unit of general formula (I): wherein R=NR6R7, or alcoholic group of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, OH, O—, alcoholic group of hyaluronic acid, amino group of deacylated hyaluronic acid; R1, R2, R3, R4=H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, —CO—(CH2)2—COOY; Y=negative charge, or H; R5=—CO—CH3, H, SO3—, acyl group derived from a carboxylic acid of the aliphatic, aromatic, arylaliphatic, cycloaliphatic, heterocyclic series, acylic group of hyaluronic acid; R6=is H or a aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; R7=is H or an aliphatic, aromatic, arylaliphatic, cycloaliphatic, or heterocyclic group, substituted or unsubstituted; wherein at least one of R or R5 forms an amide group.Type: GrantFiled: November 20, 2009Date of Patent: November 5, 2013Assignee: Fidia Farmaceutici S.p.A.Inventors: Davide Bellini, Alessandra Topai
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Publication number: 20130289267Abstract: This invention relates to thermally inhibited polysaccharides and improved processes of preparing them, wherein the improvement is dehydrating the polysaccharides under increased pressure and/or increased effective oxygen concentrations to produce compositions of improved organoleptic properties, including color, flavor and odor.Type: ApplicationFiled: May 17, 2013Publication date: October 31, 2013Applicant: CORN PRODUCTS DEVELOPMENT, INC.Inventors: Eric Weisser, Tushar Shah
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Publication number: 20130288932Abstract: According to an embodiment, a method of providing a biopolymer comprises: cryodesiccating a broth, wherein the broth comprises: (A) a biopolymer, wherein the biopolymer is an exopolysaccharide; and (B) a liquid growth medium. According to certain embodiments, the biopolymer is produced by the fermentation of at least one carbohydrate via a microbe. According to an embodiment, the microbe is a bacterium. According to another embodiment, the microbe is a fungus.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicant: HALLIBURTON ENERGY SERVICES, INC.Inventors: Andrew A.F. Mackenzie, Eric Davidson
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Publication number: 20130289255Abstract: A method to increase the molecular weight of wood mannans and xylans comprising aromatic moieties comprises the steps: a) obtaining mannan and/or xylan from wood, b) subjecting the mannan/xylan to oxidizing conditions to convert at least a fraction of the aromatic groups into radicals and reacting said radicals with each other to obtain complexes of mannan/xylan with increased molecular weight. The method is easy and cost efficient and enables to upgrade small wood mannans and xylans that are important in the pulp and paper industry into larger mannans and xylans and more defined structures which makes their isolation easier and application areas broader. Another advantage is that separation of mannans and xylans from mannans and xylans with bound aromatic groups is provided. The wood mannans and xylans with increased molecular weight can be used for the manufacture of barrier films in packages, for instance for oxygen, liquids and gas.Type: ApplicationFiled: November 23, 2011Publication date: October 31, 2013Applicant: ECOHELIX HBInventors: Gunnar Henriksson, Dimitri Areskogh, Petri Oinonen
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Patent number: 8568760Abstract: Hydrophobic ?(1?4)glucopyranose polymers useful for the preparation of implantable or injectable medical articles are described. The hydrophobic ?(1?4)glucopyranose polymer includes pendent groups having hydrocarbon groups and terminal amine or hydroxyl groups. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo. Matrices including and capable of releasing a bioactive agent in vivo are also described.Type: GrantFiled: December 30, 2010Date of Patent: October 29, 2013Assignee: Surmodics, Inc.Inventor: Emily R. Rolfes Meyering
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Publication number: 20130281549Abstract: A sterile biofilm could be engineered to isolate the glue-like substance while eliminating the adverse properties of the bacteria. The resulting sterile glue-like substance would be used to help the cells stick to the support structure. The engineered biofilm could be added to the support structure in the laboratory that produces the support structure or just prior to the addition of the cells by the user. Alternatively, the biofilm and support structure could be combined intra-corporally. This biofilm also could be used as an independent polysaccharide based adhesive with mild to moderate adhesion forces. The biofilm could serve as a surgical adhesion or grouting for cells, for tissue fixation (soft tissue to soft tissue, soft tissue to bone, etc.) and as a sealant. The biofilm could be used in conjunction with other implants and devices. The biofilm could be used to coat a stent.Type: ApplicationFiled: June 7, 2013Publication date: October 24, 2013Inventor: Peter M. Bonutti
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Publication number: 20130273097Abstract: Provided are immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacteria that contain 3-methyl-3-hydroxybutyrate- or 3-hydroxybutryate-substituted saccharides. Conjugates of 3-methyl-3-hydroxybutyrate- or 3-hydroxybutryate-substituted saccharides elicit an effective immune response against B. anthracis spores in mammalian hosts to which the conjugates are administered.Type: ApplicationFiled: June 4, 2013Publication date: October 17, 2013Inventors: Joanna Kubler-Kielb, Evguenii Vinogradov, Rachel Schneerson, Haijing Hu, Stephen H. Leppla, John B. Robbins
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Patent number: 8557968Abstract: The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or and —OSO3; R3 represents a C1-C6 alkoxy or an —OSO3, or R3 constitutes a —O—CH2— bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines.Type: GrantFiled: July 16, 2010Date of Patent: October 15, 2013Assignee: SanofiInventors: Philippe Duchaussoy, Jean Pascal Herault, Jean Marc Herbert, Maurice Petitou, Pierre Savi
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Patent number: 8557794Abstract: The present invention relates to a method for enhancing the immune system and the treatment and/or prevention of immune system related disorders in a mammal, particularly newborns, said method comprising the administration of acid oligosaccharide and neutral oligosaccharide. Food compositions suitable for use in the above method are also provided.Type: GrantFiled: October 25, 2004Date of Patent: October 15, 2013Assignee: N.V. NutriciaInventors: Bernd Stahl, Laura M'Rabet, Arjan Paul Vos, Johan Garssen, Günther Boehm
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POLYSACCHARIDE AND DERIVATIVES THEREOF, SHOWING AFFINITY TO FICOLIN-3, METHOD OF PREPARATION AND USE
Publication number: 20130266971Abstract: The invention relates to bacterial lipopolysaccharide and its components, especially native and chemically modified polysaccharides isolated from Hafnia alvei lipopolysaccharides, as well as conjugates of these polysaccharides with carriers and methods for their preparation and methods to use of these substances as ligands for human ficolin-3.Type: ApplicationFiled: June 11, 2011Publication date: October 10, 2013Applicants: INSTYTUT BIOLOGII MEDYCZNEJ POLSKIEJ AKADEMII NAUK, INSTYTUT IMMUNOLOGII I TERAPII DOSWIADCZALNEJ PANInventors: Jolanta Lukasiewicz, Anna Swierzko, Maciej Cedzynski, Czeslaw Lugowski, Anna Maciejewska, Wojciech Jachymek, Tomasz Niedziela -
Publication number: 20130259809Abstract: A process of using Isatis root polysaccharide in the manufacture of medicaments for treating and/or preventing diseases induced by influenza virus and complications thereof, wherein the molecular weight of the Isatis root polysaccharide is 3000-7000 Da, and the influenza viruses include influenza virus A, influenza virus B, avian influenza virus, such as human influenza virus H1N1, H3N2, avian influenza virus H6N2, H7N3, H9N2 and INF B. The mechanism of the Isatis root polysaccharide against influenza virus is due to the ability to inhibit the attachment of influenza virus to the host cell. The present invention also discloses a pharmaceutical composition containing the above-mentioned Isatis root polysaccharides and a method for preparing the polysaccharides.Type: ApplicationFiled: April 9, 2013Publication date: October 3, 2013Inventors: Zifeng YANG, Chuyuan LI, Yutao WANG, Suishan ZHAO, Nanshan ZHONG, Qing LIN, Zheng WANG, Sheng QIN, Wenda GUAN, Ziyao MO, Deqin WANG
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Publication number: 20130251741Abstract: The present invention provides an immunostimulatory composition comprising mannans, wherein at least 75% of the mannans are greater than about 1000 kDa and/or have at least 150 aldehyde groups. The present invention also provides for the use of this composition in vaccination and gene therapy methods, together with processes for its preparation.Type: ApplicationFiled: May 10, 2011Publication date: September 26, 2013Applicant: ASCEND BIOPHARMACEUTICALS PTY. LTD.Inventor: Geoffrey Alan Pietersz
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ALPHA 1-3 N-GALACTOSYLSTRANSFERASE WITH ALTERED DONOR SPECIFICITIES, COMPOSITIONS AND METHODS OF USE
Publication number: 20130243690Abstract: The invention generally features compositions and methods based on the structure-based design of alpha 1-3 N-Acetylgalactosaminyltransferase (alpha 3 GalNAc-T) enzymes from alpha 1-3galactosyltransferase (a3Gal-T) that can transfer 2?-modified galactose from the corresponding UDP-derivatives due to substitutions that broaden the alpha 3Gal-T donor specificity and make the enzyme a3 GalNAc-T.Type: ApplicationFiled: April 11, 2013Publication date: September 19, 2013Applicant: Government of the United Sates of America, as represented by the Secretary Department of HealthInventors: Pradman K. Qasba, Boopathy Ramakrishnan, Elizabeth Boeggeman, Marta Pasek -
Patent number: 8535688Abstract: The invention relates to a vaccine for the treatment of disease caused by Neisseria, the vaccine including one or more immunogenic components for Neisseria serogroups, as well as antibodies to the immunogenic components and methods of preventing and treating Neisseria infections. The immunogens are based on elements of the inner core lipopolysaccharide.Type: GrantFiled: December 7, 2011Date of Patent: September 17, 2013Assignee: Isis Innovation LimitedInventors: Joyce Susan Plested, Michael Paul Jennings, Margaret Ann Jaqueline Gidney, Andrew David Cox, James Clare Richards, Richard Edward Moxon
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Patent number: 8536317Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.Type: GrantFiled: December 29, 2010Date of Patent: September 17, 2013Assignee: Seikagaku CorporationInventor: Tomoya Sato
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Patent number: 8536153Abstract: The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the sulfhydryl group, a protein, a fluorescent probe, or a solid phase. The invention further relates to vaccines comprising the PIMs linked to a carrier protein or an antigen.Type: GrantFiled: November 3, 2009Date of Patent: September 17, 2013Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Peter H. Seeberger, Siwarutt Boonyarattanakalin, Bernd Lepenies
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Publication number: 20130238118Abstract: The invention disclosed herein relates to methods and means for allocating, allotting, apportioning, dispensing, distributing, preparing, portioning, meting out and/or otherwise providing, controlling and/or regulating access to quantities of foods, beverages, and/or other substances. Various embodiments of the methods and means of the invention may be performed by and/or implemented in hardware, in software, by one or more entities, and/or by some combination of hardware, software and/or one or more entities.Type: ApplicationFiled: January 30, 2013Publication date: September 12, 2013Inventor: Alfred M. Haas
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Publication number: 20130236404Abstract: The invention provides methods of preventing or treating a condition associated with DNA damage in an animal comprising the administration of a substance that interferes with the activity of the CUL4A ubiquitin ligase. The invention also provides a substance that interferes with the activity of CUL4A, as well as compositions comprising the interfering substance and a carrier. The substance of the invention preferably enhances nucleotide excision repair activity in an animal. The invention further provides methods of identifying substances that negatively or positively modulate the expression and/or activity of CUL4A.Type: ApplicationFiled: April 29, 2009Publication date: September 12, 2013Applicant: Cornell UniversityInventor: Pengbo ZHOU
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Patent number: 8530448Abstract: Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-mediated function comprise a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids, which include a portion or analogue thereof) linked to a carbohydrate or glycomimetic.Type: GrantFiled: April 2, 2010Date of Patent: September 10, 2013Assignee: Glycomimetics, Inc.Inventors: John L. Magnani, John T. Patton, Jr., Leonard M. Williams
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Patent number: 8530642Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form particulate-soluble ?-glucan. The particulate-soluble ?-glucan is capable of being dried to a powder form and subsequently re-solubilized.Type: GrantFiled: July 11, 2011Date of Patent: September 10, 2013Assignee: Biopolymer Engineering, Inc.Inventor: Donald J. Cox
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Publication number: 20130231460Abstract: The present invention relates to a method for concentrating one or more target compounds in a liquid sample, a device for carrying out this method and a kit for processing a biological sample comprising such a device.Type: ApplicationFiled: September 7, 2011Publication date: September 5, 2013Applicant: Qiagen GmbHInventors: Christoph Erbacher, Vera Holländer, Markus Müller, Martin Schlumpberger, Marion Schmidt, Markus Sprenger-Haussels
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Publication number: 20130228332Abstract: Novel derivatives of tris(2-hydroxyphenyl)methanes which have, as functional groups, polyalkoxy groups unmodified or modified with terminal hydrophilic groups, preparation of such compounds and use thereof, especially for mineral oil production.Type: ApplicationFiled: November 21, 2012Publication date: September 5, 2013Inventors: Sophie Maitro-Vogel, Roman Benedikt Raether, Markus Hansch
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Patent number: 8524886Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation.Type: GrantFiled: February 15, 2010Date of Patent: September 3, 2013Assignee: Colorado State University Research FoundationInventors: Susan P. James, Min Zhang, Guy Beauregard
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Patent number: 8524884Abstract: An outer layer material having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. Prior to intermingling with the guest, a host blend may be produced to include a physical blend of a hydrophobic polymer host and a maleated hydrophobic co-host (preferably, an anhydride functionalized hydrophobic polymer, whereby the polymer so functionalized, is the same as that selected for the host). The intermingling of the guest and host, or host-co-host blend, includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between.Type: GrantFiled: April 21, 2008Date of Patent: September 3, 2013Assignee: Colorado State University Research FoundationInventors: Susan P. James, Min Zhang, Guy Beauregard, Rachael Kurkowski Oldinski
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Publication number: 20130224305Abstract: The invention provides a screening method for identifying an insect-specific TRPA1 modulator by comparing modulation of an insect TRPA1 and a mammalian TRPA1. The invention further provides method of insect control by applying to an insect a insect-specific TRPA1 modulator identified by the screening method.Type: ApplicationFiled: March 17, 2011Publication date: August 29, 2013Applicant: BRANDEIS UNIVERSITYInventors: Paul Garrity, Kyeongjin Kang
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Publication number: 20130225403Abstract: Described is a composition for seed treatment comprising a plant seed-binding protein, preferably an antigen-binding plant seed-binding protein. In one embodiment, the seed-binding protein is binding a polysaccharide, preferably pectin. Further described is the use of a plant seed-binding protein to bind a plant-enhancing agent to a plant seed, and to a method for treating plant seeds.Type: ApplicationFiled: August 26, 2011Publication date: August 29, 2013Inventors: Peter Verheesen, Chris De Jonghe, Erik Jongedijk
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Patent number: 8518430Abstract: Solid pharmaceutical compositions for parenteral injection comprising a binder and at least one therapeutic agent. The pharmaceutical composition has the strength to be injected directly with the need of using cannulas or the like.Type: GrantFiled: October 31, 2011Date of Patent: August 27, 2013Assignee: Novo Nordisk A/SInventors: Thomas Buch-Rasmussen, James M. Flink, Jens Ulrich Poulsen, Søren Aasmul, Philip Hansen, Claus Juul Mortensen
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Publication number: 20130217068Abstract: The present invention relates to nucleic acid and amino acid sequences from Akkermansia muciniphila and from Bacteroides fragilis, coding for/representing novel alpha-1,3-fucosyltransferases. The invention also provides uses and methods for using the alpha-1,3-fucosyltransferases to generate fucosylated products, such as oligosaccharides, (glyco)proteins, or (glyco)lipids, in particular of 3-fucosyllactose.Type: ApplicationFiled: April 10, 2013Publication date: August 22, 2013Applicant: JENNEWEIN BIOTECHNOLOGIE GMBHInventor: JENNEWEIN BIOTECHNOLOGIE GMBH
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Patent number: 8513408Abstract: A low calcium sensitive (calcium stable) high acyl gellan gum is prepared for enhanced colloidal stability in beverages. The low calcium sensitive high acyl gellan gum has superior suspension performance for colloidal stability compared to other high acyl gellan gums. The low calcium sensitive high acyl gellan gum is prepared by adjusting the pH of a gellan fermentation broth (polymer solution) prior to pasteurization and reducing the pasteurization hold time compared to conventional pH levels and hold times.Type: GrantFiled: May 24, 2005Date of Patent: August 20, 2013Assignee: CP Kelco U.S., Inc.Inventors: C. Ronnie Yuan, Neil Morrison, Ross Clark
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Publication number: 20130206034Abstract: A dried distiller soluble based biopolymer, processes for forming the biopolymer, and articles of manufacture thereof. The produced dried distillers solubles derives from co-products of corn fermentation facilities and is comprised in part of water-soluble proteins. A biopolymer consists essentially of dried distillers solubles, and an article of manufacture includes a biopolymer consisting of dried distillers solubles and an optional additive. The process of forming dried distiller solubles involves separating whole stillage into a liquid fraction and a solid fraction, wherein the liquid fraction comprises water soluble proteins in an amount greater than the solid fraction, and wherein the solid fraction has a higher solid content than the liquid fraction. The liquid fraction is sprayed at an elevated temperature to remove at least a portion of moisture in the liquid fraction and form particles and granules of the liquid fraction.Type: ApplicationFiled: February 15, 2013Publication date: August 15, 2013Applicant: GS CLEANTECH CORPORATIONInventor: GS CLEANTECH CORPORATION
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Publication number: 20130210083Abstract: Thermostable enzyme technology for algal bioconversion The present invention relates to thermostable enzyme systems suitable for use in the production of biofuels and bio-products from algae, and to a method of producing energy feedstocks, stocks, specifically (i) fermentable sugars and (ii) lipid fractions from algae, for the production of biofuels such as bioethanol, biobutanol and bio-oils or biodiesel, as well as other value-added biomolecules (e.g. proteins, peptides, oils, pigments, nucleic acids).Type: ApplicationFiled: February 8, 2011Publication date: August 15, 2013Applicants: AER SUSTAINABLE ENERGY LIMITED, NATIONAL UNIVERSITY OF IRELAND, GALWAYInventors: Patrick Murray, Sara Fernandes, Maria Tuohy
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Patent number: 8507659Abstract: It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a chemically modified biopolymer or polypeptide, wherein a biopolymer or polypeptide is chemically modified in a reaction solution containing an organic fluorine compound.Type: GrantFiled: November 28, 2008Date of Patent: August 13, 2013Assignee: FUJIFILM CorporationInventors: Shouji Ooya, Tetsuo Hiratou, Kentaro Nakamura
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Patent number: 8507461Abstract: The present invention relates to compounds which are capable of exerting an inhibitory effect on the Na+ glucose cotransporter SGLT in order to hinder glucose and galactose absorption, as well as on lipase thus reducing dietary triglyceride metabolism, for use in the treatment of conditions which benefit therefrom (diabetes, Metabolic Syndrome, obesity, prevention of weight gain or aiding weight loss). These compounds comprise a non-absorbable, non-digestible polymer having a glucopyranosyl or galactopyranosyl or equivalent moiety stably and covalently linked thereto, said glucopyranosyl or galactopyranosyl moiety being able to occupy the glucose-binding pocket of a SGLT transporter.Type: GrantFiled: September 6, 2006Date of Patent: August 13, 2013Inventor: Abdalla Rifai
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Publication number: 20130203983Abstract: This invention is directed to a process for making a thermally inhibited polysaccharide by dehydrating a polysaccharide to substantially anhydrous or anhydrous conditions and thermally inhibiting the substantially anhydrous or anhydrous polysaccharide at a temperature of 100° C. or greater for a time sufficient to inhibit the polysaccharide in an oxygen enriched concentration of at least 6.5 moles/m3.Type: ApplicationFiled: August 9, 2012Publication date: August 8, 2013Applicant: CORN PRODUCTS DEVELOPMENT, INC.Inventors: Thomas J. English, Kamlesh Shah, James J. Kasica, Christopher C. Lane, Tushar Shah
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Patent number: 8501710Abstract: A method of treating an ulcer comprising applying to the ulcer a preparation comprising a water-soluble ?-(1,3) glucan with ?-(1,6) linked side-chains, where the side-chains comprise ?-(1,3) linkages or up to four consecutive ?-(1,6) linkages as active ingredients.Type: GrantFiled: May 19, 2004Date of Patent: August 6, 2013Assignee: Biotec Pharmacon ASAInventors: Rolf Engstad, Rolf Seljelid
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Publication number: 20130195802Abstract: A cellular constituent is lysed from, produced by and/or isolated from one or more bacteria from the genus Bacteroides, and the cellular constituent, a derivative thereof, and/or one or more bacteria from the genus Bacteroides, or a modified form thereof, is employed in compositions and methods for modulating an inflammatory response.Type: ApplicationFiled: June 1, 2011Publication date: August 1, 2013Applicant: MOORE RESEARCH ENTERPRISES LLCInventor: Brenda E. Moore
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Publication number: 20130190267Abstract: Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Applicant: Actamax Surgical Materials, LLCInventor: Actamax Surgical Materials, LLC
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Publication number: 20130178616Abstract: The present invention relates to the use of at least one compound of formula (III), (IV), (V) or (VI), in which p is an integer from 0 to 9; and R2 represents hydrogen, allyl, methylnaphthyl, benzyl, paramethoxybenzyl, or halogenoacetyl, for the preparation of a medicament for treating diseases such as tumors, cancer, viral disease, bacterial disease, fungal disease, disease of the immune system, auto-immune disease or disease linked to a deficiency in immunostimulation, in human beings and warm-blooded animals. The invention also relates to new products having a mannose or mannitol termination as well as a method for preparing them.Type: ApplicationFiled: November 19, 2012Publication date: July 11, 2013Applicant: ASE & BIO.Inventor: ASE & BIO.
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Publication number: 20130177641Abstract: While tumor hypoxia is recognized as a key barrier to effective chemo and radiation therapy of solid tumor malignancies, and an important biological mediator of more aggressive tumor phenotype and behavior for over 50 years, prior attempts to improve tumor oxygenation have relied on increasing the total amount of oxygen bound to each molecule of natural hemoglobin (e.g. through hyperbaric oxygen treatments), increasing the ease of release of oxygen from hemoglobin (through the introduction of exogenous allosteric small molecules), or increasing the total amount of oxygen in the body by injecting perfluorocarbon emulsions, or polymerized or pegylated compositions of natural human or bovine hemoglobin. The embodiments provide a novel approach of introducing into the vascular system agents that possess inherently higher-affinities for molecular oxygen that that of natural human hemoglobin, and coupling these agents with inert carriers that shield them from unwanted biological interactions within the body.Type: ApplicationFiled: January 9, 2012Publication date: July 11, 2013Applicant: Vindico NanoBio Technology Inc.Inventor: P. Peter Ghoroghchian
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Publication number: 20130172548Abstract: A method for purifying, separating and/or isolating an oligosaccharide or a salt thereof is presented. An embodiment of the invention is based upon the formation of anomeric O-benzyl/substituted O-benzyl derivatives in a selective anomeric alkylation reaction.Type: ApplicationFiled: July 15, 2011Publication date: July 4, 2013Applicant: Glycom A/S, Kgs.Inventors: Gyula Dekany, Istvan Bajza, Károly Ágoston, Ignacio Figueroa Pérez, Markus Hedros, Andreas Schroven, Ioannis Vrasidas, Julien Boutet, Lars Kröger, Christoph Röhrig, Imre Kovacs, Péter Trinka, Ágnes Ágoston, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa, Sándor Demkó, László Kalmár, Elise Champion
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Publication number: 20130172547Abstract: Compositions comprising C5 and C6 saccharides of varying degrees of polymerization and low levels of undesirable impurities, such as compounds containing sulfur, nitrogen, or metals, are disclosed.Type: ApplicationFiled: October 11, 2012Publication date: July 4, 2013Applicant: RENMATIX, INC.Inventor: Renmatix, Inc.
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Publication number: 20130171696Abstract: The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an ?-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.Type: ApplicationFiled: July 15, 2011Publication date: July 4, 2013Applicant: Glycom A/SInventors: Andreas Schroven, Elise Champion, Gyula Dekany, Christoph Röhrig, Ioannis Vrasidas, Ignacio Figueroa Pérez, Markus Hederos, Julien Boutet, Ágnes Ágoston, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa, Sándor Demkó, Lars Kröger