Polysaccharides Patents (Class 536/123.1)
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Patent number: 8846899Abstract: Disclosed are saccharide and phosphocholine derivatives. The derivatives include azide and alkyne derivatives which form one end of a variable length carbon chain. The opposite end of the variable length carbon chain is covalently linked to the saccharide or phosphocholine. The saccharide may be, for instance, a maltoside. The alkyne and azide derivatives of the saccharides and phosphocholine may be reacted together to form amphiphilic molecules useful in cellular membrane studies and applications. By adjusting the length of the carbon chain, the biochemical and biophysical properties of the resultant 1,4-disubstituted 1,2,3-triazole compounds may be custom tailored for the intended application. Resultant molecules may form micelles, bicelle, lipid bilayers and other like structures useful in the isolation and purification of membrane bound or membrane associated proteins and biochemical components.Type: GrantFiled: October 12, 2011Date of Patent: September 30, 2014Assignee: Anatrace Products, LLCInventors: Benjamin R. Travis, Ritesh Mittal, Lijun Huang, Liang Tang
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Publication number: 20140286996Abstract: The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.Type: ApplicationFiled: June 5, 2014Publication date: September 25, 2014Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique - CNRS, Universite de la Mediterranee - Aix-Marseille II, Universidad de NavarraInventors: Jean-Pierre Gorvel, Vilma Arce Gorvel, Maite Iriarte, Ignacio Moriyon, Raquel Conde-Alvarez
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Publication number: 20140288023Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: October 24, 2013Publication date: September 25, 2014Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20140288297Abstract: A mesoporous material is derived from a polysaccharide by thermally assisted partial carbonisation after expansion. The polysaccharide is an acid containing polysaccharide or mixture of polysaccharides.Type: ApplicationFiled: December 23, 2013Publication date: September 25, 2014Applicant: THE UNIVERSITY OF YORKInventors: Robin Jeremy White, James Hanley Clark, Vitaliy L'vovich Budarin, Duncan James MacQuarrie
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Publication number: 20140288298Abstract: The present invention provides a method for efficiently producing monosaccharides, oligosaccharides, and furfurals from biomass. A biomass is hydrolyzed under conditions under which monosaccharides, oligosaccharides, and furfurals are produced while continuously supplying an aqueous suspension of the biomass from a supply port of a continuous primary hydrolysis device and moving the suspension through the device. A hydrolysis solution is continuously discharged from a discharge port of the continuous hydrolysis device, and a hydrolysis solution containing monosaccharides, oligosaccharides, and furfurals are extracted from an intermediate extraction port provided at any position between the supply port and the discharge port of the continuous primary hydrolysis device. The extracted hydrolysis solution is then subjected to secondary hydrolysis.Type: ApplicationFiled: November 2, 2012Publication date: September 25, 2014Applicant: Oji Holdings CorporationInventors: Seiji Nakagame, Nobuhisa Dano, Takayuki Obuchi, Shinya Hagiwara, Yosuke Uchida, Koki Kisara, Tomoaki Sasaki
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Patent number: 8841279Abstract: The invention provides a pharmaceutical composition comprising a macromolecular drug and an oligoguluronate or oligogalacturonate, e.g., having a number average degree of polymerization in the range 5 to 18, a guluronate (or galacturonate) fraction (FG) of at least 0.80, a mannuronate fraction (FM) of no more than 0.20, and having at least 95% mole with a degree of polymerization less than 20. The composition may be used in a method of treatment which comprises administering the composition to a mucosal surface in a human or non-human vertebrate subject.Type: GrantFiled: April 11, 2008Date of Patent: September 23, 2014Assignee: Norwegian University of Science and TechnologyInventors: Catherine Taylor, Kurt Ingar Draget, Olav Asmund Smidsrod
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Publication number: 20140255477Abstract: While tumor hypoxia is recognized as a key barrier to effective chemo and radiation therapy of solid tumor malignancies, and an important biological mediator of more aggressive tumor phenotype and behavior for over 50 years, prior attempts to improve tumor oxygenation have relied on increasing the total amount of oxygen bound to each molecule of natural hemoglobin (e.g. through hyperbaric oxygen treatments), increasing the ease of release of oxygen from hemoglobin (through the introduction of exogenous allosteric small molecules), or increasing the total amount of oxygen in the body by injecting perfluorocarbon emulsions, or polymerized or pegylated compositions of natural human or bovine hemoglobin. The embodiments provide a novel approach of introducing into the vascular system agents that possess inherently higher-affinities for molecular oxygen that that of natural human hemoglobin, and coupling these agents with inert carriers that shield them from unwanted biological interactions within the body.Type: ApplicationFiled: April 25, 2014Publication date: September 11, 2014Applicant: VINDICO NANOBIO TECHNOLOGY INC.Inventor: P. Peter GHOROGHCHIAN
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Publication number: 20140256931Abstract: The present disclosure relates carbonaceous materials and to methods of using such carbonaceous materials for purifying oligomers produced from depolymerized biomass, such as lignocellulosic biomass.Type: ApplicationFiled: October 18, 2012Publication date: September 11, 2014Applicants: BP CORPORATION NORTH AMERICA INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Po-Wen Chung, Alexandre Charmot, Alexander Katz, Amit A. Gokhal
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Publication number: 20140256673Abstract: The embodiments herein provide a method for isolation and purification of a novel oligosaccharide molecule from the fruits of Rosa arvensis for the treatment of diabetes. The fruit is dried, powdered and subjected to deionized water. The deionized water solution is subjected to silica gel column and the filtrate is subjected to ethanol-water mixture. The filtrate is subjected to column chromatography. The purified extract is structurally and chemically analyzed to find that the molecule is oligosaccharide. The purified oligosaccharide is administered to diabetic patients for 21 days. After the administration of oligosaccharide for 21 days the pancreatic tissues are collected and the blood glucose level in fasting and non fasting states is measured to find that there is significant effect in the blood glucose levels and the pancreatic tissue/cell regeneration after administration of the isolated oligosaccharide. The toxicity tests reveal that the oligosaccharide is non-toxic in nature.Type: ApplicationFiled: January 26, 2014Publication date: September 11, 2014Inventor: Gholamreza Bahrami
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Patent number: 8828905Abstract: The present invention relates to a porous base matrix having formyl group, which base matrix has a structure represented by the formula (2) as a spacer, which structure is obtained by cleaving a group represented by the formula (1): wherein, R1 represents a group forming a five-membered ring or a six-membered ring with —CH(OH)—CH(OH)—; a method for producing the porous base matrix; and an adsorbent obtained by binding a ligand on the porous base matrix. By the present invention, a high-intensity base matrix for an adsorbent and an adsorbent are provided. The amount of a ligand leaked from the adsorbend is small.Type: GrantFiled: May 30, 2008Date of Patent: September 9, 2014Assignee: Kaneka CorporationInventors: Yoshikazu Kawai, Naomi Kawahara
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Patent number: 8828970Abstract: A method comprising administering an oligosaccharide composition to an organism having a gastrointestinal system to affect the production of GHG produced by the organism allowing for a reduction of the GHG produced by the organism while optimizing the health, feed intake, and protein synthesis of the organism so that management of the organism may realize the synergistic effects of maximizing both typical organism commodity-type concerns (e.g., size and production metrics) and atypical organism commodity-type concerns (e.g., carbon credit trading/monetization). A gas-reducing composition comprising soluble extractable material from a lignocellulosic source.Type: GrantFiled: August 26, 2010Date of Patent: September 9, 2014Assignee: Georgia-Pacific Wood Products LLCInventors: Matthew W. Lowe, Anne Chace Hopkins, Thomas A. Lehtinen
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Patent number: 8828967Abstract: New low molecular weight complexes between iron and maltobionic acid that can be administered parenterally, preferably intramuscularly or subcutaneously, in the treatment of anemic states, caused by iron deficiencies, and new pharmaceutical compositions adapted for this use. In particular, the invention provides a new complex between preferably trivalent iron and maltobionic acid that is characterized by a molecular weight Mw between 10,000 and 30,000 Da, by a polydispersity of 1.0-1.8 and by an iron content between 25% and 40% by weight.Type: GrantFiled: June 8, 2011Date of Patent: September 9, 2014Assignee: Biofer S.p.A.Inventors: Michele Autuori, Dario Bosi, Alessandro Lapini Sacchetti, Egidio Marchi
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Publication number: 20140242798Abstract: A polishing composition of the present invention is used for polishing an object containing a phase-change alloy and is characterized by containing an ionic additive. Examples of the ionic additive include a cationic surfactant, an anionic surfactant, an amphoteric surfactant, and a cationic water-soluble polymer.Type: ApplicationFiled: September 28, 2012Publication date: August 28, 2014Applicant: FUJIMI INCORPORATIONInventors: Yoshihiro Izawa, Yukinobu Yoshizaki
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Publication number: 20140242665Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: ApplicationFiled: February 24, 2014Publication date: August 28, 2014Applicant: APPLIED BIOSYSTEMS, LLCInventors: Joe Y. LAM, Steven MENCHEN, Ruiming ZOU, Scott BENSON
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Patent number: 8815239Abstract: The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.Type: GrantFiled: May 16, 2008Date of Patent: August 26, 2014Assignees: Institut Pasteur, Centre National de la Recherche Scientifique, Universite Paris DescartesInventors: Laurence Mulard, Julien Boutet, Catherine Guerreiro, Farida Nato, Philippe Sansonetti, Armelle Phalipon
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Patent number: 8815522Abstract: The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.Type: GrantFiled: January 2, 2009Date of Patent: August 26, 2014Assignee: Massachusetts Institute of TechnologyInventors: Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan
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Patent number: 8815831Abstract: The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of Acinetobacter, said method comprising using said antibiotic together with an alginate oligomer. The Acinetobacter may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with Acinetobacter. In another aspect the method can be used to combat Acinetobacter contamination of a site e.g., for disinfection and cleaning purposes.Type: GrantFiled: June 3, 2010Date of Patent: August 26, 2014Assignee: Algipharma ASInventors: Edvar Onsoyen, Rolf Myrvold, Arne Dessen, David Thomas, Timothy Rutland Walsh
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Publication number: 20140234942Abstract: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the proteins stored in the dry solid substrate are also described.Type: ApplicationFiled: April 25, 2014Publication date: August 21, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Ernest William Kovacs, Erik Leeming Kvam, Bing Li, Frank John Mondello
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Publication number: 20140235573Abstract: The present invention relates to the use of heparin derivatives for the prevention and/or treatment of cancer and/or cancer metastasis. The heparin derivatives are substantially 2-O and/or 6-O desulphated heparins which function as inhibitors of galectin-3 activity.Type: ApplicationFiled: October 1, 2012Publication date: August 21, 2014Inventors: Jeremy Ewan Turnbull, Edwin Alexander Yates, Jonathan Michael Rhodes, Lu-Gang Yu
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Publication number: 20140235850Abstract: The invention relates to a method for making precursors of HMO core structures comprising a step of reacting an N-acetyllactosamine or lacto-N-biose derivative donor with a lactose or N-acetyllactosamine derivative acceptor, wherein the donor is an oxazoline donor.Type: ApplicationFiled: October 1, 2012Publication date: August 21, 2014Inventors: Imre Kovács, István Bajza, Markus Hederos, Gyula Dekany, Sándor Demkó, Nikolay Khanzhin
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Patent number: 8809300Abstract: Disclosed is a depolymerized glycosaminoglycan from Thelenota ananas (dTHG), weight average molecular weight of which is about 8000˜20000 Da, and monosaccharide components of which are acetylgalactosamine (GalNAc), glucuronic acid (GlcUA), fucose (Fuc) or their sulfates (expressed as —OSO3?), in which molar ratio of GalNAc:GlcUA:Fuc:—OSO3? is about 1:(1±0.3):(1±0.3):(3.5±0.5). Said dTHG is a potent endogenous inhibitor of factor X, which has good anticoagulant and antithrombotic activity, and can be used for the prevention and/or treatment of thrombotic diseases. Also provided is a method for preparing said dTHG, which comprises steps of 1) extracting and obtaining fucosylated glycosaminoglycan (THG) from the body wall of Thelenota ananas; 2) depolymerizing THG to obtain dTHG by method of peroxide depolymerization or method of peroxide depolymerization catalyzed by catalyst of the fourth period transition metal ions; 3) removing impurities with lower and/or higher molecular weight in dTHG.Type: GrantFiled: October 25, 2010Date of Patent: August 19, 2014Assignee: Shenzhen Neptunus Pharmaceutical Co., Ltd.Inventors: Jinhua Zhao, Hui Kang, Mingyi Wu, Weizhen Zeng, Zi Li, Yuan Gao, Jing Cui, Zhiguo Wang, Hanlin Feng, Lin Yu
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Publication number: 20140227717Abstract: Methods, compositions and kits are disclosed directed at posaconazole fragments, immunogens, signal generating moieties, antibodies that bind posaconazole and immunoassays for detection of posaconazole.Type: ApplicationFiled: February 10, 2014Publication date: August 14, 2014Inventors: Johnny Valdez, Soon J. Oh, Byung Sook Moon
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Patent number: 8802652Abstract: Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.Type: GrantFiled: April 23, 2009Date of Patent: August 12, 2014Assignee: Medtronic, Inc.Inventors: Matthew Franco Myntti, Dana A. Oliver, Brian Vaccaro
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Publication number: 20140220090Abstract: This invention addresses a cosmetic composition intended for making up the skin (face and body) that comprises: (a) a sensorial modification system that encompasses at least babassu polysaccharide; (b) at least one treated pigment; and (c) at least one optical diffuser. This cosmetic composition covers the skin evenly with make-up, with full coverage of the skin region, good adhesion, minimizing excessive shine, and leaving the skin feeling soft, satiny and velvety, among other advantages desired in a product such as this. This invention also addresses cosmetic products that encompass the above-mentioned cosmetic composition. This invention also encompasses the cosmetic use of babassu polysaccharide as a sensorial modifier.Type: ApplicationFiled: August 31, 2011Publication date: August 7, 2014Applicant: NATURA COSMÉTICOS S.AInventors: Alcione Del Rey Castriotto, Cinthia Fernanda De Souza Ferreira, Luciana Gandini Andreo, Luciana Feria, Pâmela Araujo Rodrigues Machiutti, Simone Esteves Soares
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Publication number: 20140219917Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.Type: ApplicationFiled: February 26, 2014Publication date: August 7, 2014Applicants: Emory University, Georgia State Research Foundation, Georgia Tech Research CorporationInventors: Niren MURTHY, Eric Seth Gilbert, Xinghai Ning, Mark Goodman, Bryan Stubblefield
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Patent number: 8795746Abstract: A therapeutic formulation containing mucin glycans derived from one or a number of nutritionally appropriate sources is described.Type: GrantFiled: February 15, 2012Date of Patent: August 5, 2014Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventor: Justin L. Sonnenburg
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Publication number: 20140212457Abstract: The present invention relates to compounds which are capable of exerting an inhibitory effect on the Na+ glucose cotransporter SGLT in order to hinder glucose and galactose absorption, as well as on lipase thus reducing dietary triglyceride metabolism, for use in the treatment of conditions which benefit therefrom (diabetes. Metabolic Syndrome, obesity, prevention of weight gain or aiding weight loss). These compounds comprise a non-absorbable, non-digestible polymer having a glucopyranosyl or galactopyranosyl or equivalent moiety stably and covalently linked thereto, said glucopyranosyl or galactopyranosyl moiety being able to occupy the glucose-binding pocket of a SGLT transporter.Type: ApplicationFiled: August 12, 2013Publication date: July 31, 2014Inventor: Abdalla Rifai
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Patent number: 8790548Abstract: A carbonaceous material is derived from a polysaccharide by carbonization. The polysaccharide is preferably a starch. The carbonaceous material has mesoporosity and is useful as a solid catalytic support.Type: GrantFiled: March 15, 2007Date of Patent: July 29, 2014Assignee: University of YorkInventors: Vitaliy Budarin, James Hanley Clark, Rafael Luque, Duncan James MacQuarrie, Krzysztof Milkowski, Robin Jeremy White
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Publication number: 20140206020Abstract: Methods, compositions and kits are disclosed directed at voriconazole derivatives, immunogens, signal generating moieties, antibodies that bind voriconazole and immunoassays for detection of voriconazole.Type: ApplicationFiled: January 17, 2014Publication date: July 24, 2014Inventors: Johnny Valdez, SOON J. OH, BYUNG SOOK MOON
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Publication number: 20140206839Abstract: The present specification provides for methods for purifying fibroins, purified fibroins, methods of conjugating biological and synthetic molecules to fibroins, fibroins conjugated to such molecules, methods of making fibroin hydrogels, fibroin hydrogels and fibroin hydrogel formulations useful for a variety of medical uses, including, without limitation uses as bulking agents, tissue space fillers, templates for tissue reconstruction or regeneration, cell culture scaffolds for tissue engineering and for disease models, surface coating to improve medical device function, or drug delivery devices.Type: ApplicationFiled: March 31, 2014Publication date: July 24, 2014Applicant: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca L. Horan, Adam L. Collette, Jingsong Chen, Dennis Van Epps
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Patent number: 8785621Abstract: A malleable compound according to the invention for use as a disinfectant comprises water, 25 to 40% by weight of a solvent component comprising low-molecular, water-miscible alcohols, 1 to 10% by weight of an active bactericidal component, 3 to 6% by weight hydroxypropylated polygalactomannan with an etherification level of between 0.3 and 1.5 and 0.1 to 0.5% by weight boracic acid or an equivalent amount of boron ions.Type: GrantFiled: March 16, 2011Date of Patent: July 22, 2014Assignee: Joker AGInventors: Meinrad Flury, Rene H. Dietrich
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Patent number: 8785622Abstract: A substantially boron-free method for making a cationic guar comprises reacting particles of polysaccharide with a derivatizing agent to produce derivatized polysaccharide particles, washing the derivatized polysaccharide particles, and contacting, prior to or after the washing step, the particles with a glyoxal compound in order to crosslink the derivatized polysaccharide particles.Type: GrantFiled: January 30, 2009Date of Patent: July 22, 2014Assignee: Rhodia OperationsInventors: Caroline Mabille, Kraig Luczak
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Patent number: 8785417Abstract: Absorbent boronate-galactomannan complexes comprising a hydrophobic group are disclosed. The boronate-galactomannan complexes are solid materials capable of gel forming upon contacting with liquids. The boronate-galactomannan complexes are particularly suitable for absorbing liquids.Type: GrantFiled: February 6, 2009Date of Patent: July 22, 2014Assignee: Archer Daniels Midland Co.Inventors: Anne-Claude Couffin, Mohammed Berrada, André Laforest, Nicolas Nourry
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Patent number: 8785416Abstract: The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular disease, of a traumatic brain injury or of a traumatic spinal cord injury. The present invention also relates to the use of said sulphated disaccharides for the preparation of a neuroprotective medicament or of an antioxidant medicament. The neurodegenerative and/or neurovascular diseases are preferably: Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke.Type: GrantFiled: December 22, 2010Date of Patent: July 22, 2014Assignees: Bioiberica, S.A., Universidad Autonoma de MadridInventors: Josep Verges Milano, Antonio Garcia Garcia, Ramon Ruhi Roura, Eulalia Montell Bonaventura, Manuela Garcia Lopez, Carlos Raul Alaez Verson, Josep Escaich Ferrer, Javier Egea Maiquez, Pilar Negredo Madrigal, Silvia Lorrio Gonzalez
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Publication number: 20140200339Abstract: Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.Type: ApplicationFiled: November 8, 2013Publication date: July 17, 2014Applicant: MOMENTA PHARMACEUTICALS, INC.Inventors: Sucharita Roy, Takashi K. Kishimoto, Ganesh Kaundinya
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Patent number: 8778909Abstract: Methods for applying injectable fillers are provided. In some embodiments, the methods can extend effectiveness of the injectable filler. In some embodiments, the methods can provide for an elevated level of effectiveness of the injectable filler. In some embodiments, the methods can prolong the effectiveness of the injectable filler.Type: GrantFiled: May 31, 2013Date of Patent: July 15, 2014Assignee: Medicis Pharmaceutical CorporationInventors: Mitchell S. Wortzman, Rhoda Narins, Xiaoming Lin
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Publication number: 20140190367Abstract: This invention concerns a biopolymer consisting of a polysaccharide composed of galactose (50-90%), glucose (1-25%), mannose (1-25%) and rhamnose (0.5-20%), which may additionally contain, in trace amounts, xylose, fucose, ribose, arabinose and/or fructose. The galactose-rich polymer also contains non-saccharide components, namely, acyl groups. This invention also concerns a process for the production of the galactose-rich polymer, by microbial fermentation using glycerol or glycerol-rich substrates as carbon source, and recovery of the polymer from the culture broth. From the process for the production of the galactose-rich polymer results the co-production of intracellular biopolymers, namely, polyhydroxyalkanoates.Type: ApplicationFiled: March 5, 2014Publication date: July 10, 2014Applicant: 73100- SETENTA E TRES MIL E CEM, LDA.Inventors: Maria d'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Cristina Paula Pereira Da Cunha Rodrigues Oliveira, Maria Filomena Andrade De Freitas, Victor Manuel Delgado Alves, Joana Oliveira Pais
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Publication number: 20140193416Abstract: The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap-(1?3)-?-D-Glcp-(1?4)-[a-L-Rhap-(1?3]-a-D-Glcp-(1?2)-a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools.Type: ApplicationFiled: July 30, 2012Publication date: July 10, 2014Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Peter H. Seeberger, Christopher E. Martin, Felix Broecker, Chakkumkal Anish
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Patent number: 8765416Abstract: The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-?-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.Type: GrantFiled: September 3, 2010Date of Patent: July 1, 2014Assignee: Hayashibara Co., Ltd.Inventors: Takashi Shibuya, Seisuke Izawa, Tomoyuki Nishimoto, Shigeharu Fukuda, Toshio Miyake
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Patent number: 8764991Abstract: A process for dewatering biomass material comprising polysaccharide and water. The process comprises wetting the biomass material with a wetting composition comprising an alcohol to form a biomass slurry comprising wetted biomass material and a liquid component, mechanically separating a portion of the liquid component from the biomass slurry, and mechanically separating at least a portion of the water from the wetted biomass material. A process for extracting polysaccharide from the biomass material and a dewatered biomass material are also disclosed.Type: GrantFiled: October 31, 2012Date of Patent: July 1, 2014Assignee: CP Kelco ApSInventors: Jens Eskil Trudsoe, Helle Bech Olsen, Mogens Andersen
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Publication number: 20140178427Abstract: The present invention pertains to medicinal technical field, relates to a Radix isatidis total polysaccharide and fractions thereof and their uses as vaccine adjuvant. Specifically, it relates to a Radix isatidis total polysaccharide as well as neutral polysaccharide fraction and acidic polysaccharide fraction extracted from Chinese medicinal material Radix isatidis, and to their uses as vaccine adjuvant or uses in manufacture of vaccine composition. The present invention further relates to a vaccine adjuvant and vaccine preparation comprising the above Radix isatidis total polysaccharide or polysaccharide fraction, a method for preparing antibody, and a method for immunization or inoculation. The Radix isatidis total polysaccharide as well as neutral polysaccharide fraction and acidic polysaccharide fraction of the present invention all can be used as adjuvant for attenuated vaccines, protein vaccines, DNA vaccines or polypeptide vaccines.Type: ApplicationFiled: June 24, 2011Publication date: June 26, 2014Inventors: Junjie Shan, Yuxia Wang, Wei Jiang, Junhua Wu, Peiyuan Jia, Ting Zhu, Xiunan Zhao, Yulin Diao, Chenyu Wang
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Publication number: 20140170150Abstract: An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a Campylobacter organism. There is also provided an antibody or antisera against the compound, having particular use to diagnose the presence of an infection caused by a Campylobacter organism.Type: ApplicationFiled: February 11, 2011Publication date: June 19, 2014Applicant: The Governors of the University of AlbertaInventors: Christine SZYMANSKI, Harald NOTHAFT
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Publication number: 20140161837Abstract: The disclosure provides a vaccine adjuvant, including a polysaccharide derived from Antrodia camphorata (also named Antrodia cinnamomea or Taiwanofungus camphoratus) fruiting body, wherein the molecular weight of the polysaccharide is greater than 100 K Da. Furthermore, the polysaccharide is obtained by an extraction process, and the extraction process includes: (a) adding powder of the Antrodia camphorata fruiting body into water to form a mixture; (b) heating the mixture under reflux; (c) after step (b), removing an insoluble matter from the mixture; (d) after step (c), adding ethanol into the mixture to perform a precipitating step and obtain a precipitate; and (e) performing an isolating step to the precipitate to obtain a fraction the molecular weight of which is greater than 100 K Da of the precipitate.Type: ApplicationFiled: December 9, 2013Publication date: June 12, 2014Applicant: Industrial Technology Research InstituteInventors: I-Horng PAN, I-Haung LU, Hsin-Jan YAO, Hsin-Chieh WU, Chi-Chien LIN
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Patent number: 8748582Abstract: The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilize the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, R1 represents H or C1-3 alkyl, R2 is an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker.Type: GrantFiled: October 15, 2010Date of Patent: June 10, 2014Assignee: Monash UniversityInventors: Milton T W Hearn, Anjali Makarand Bhagwat, William Roy Jackson, Simon John Mountford
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Patent number: 8748595Abstract: Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.Type: GrantFiled: February 1, 2008Date of Patent: June 10, 2014Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Patrick N. Shaklee, Jennifer Bahr-Davidson, Srinivasa Prasad, Kirk Johnson
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Publication number: 20140154200Abstract: The present invention relates to a non-cellulosic polysaccharide derivative: i) having a mean average molecular weight (Mw) from about 100,000 g/mol, preferably from about 150,000 g/mol and more preferably from about 200,000 g/mole to about 2,000,000 g/mol, preferably to about 1,800,000 g/mol and more preferably to about 1,400,000 g/mole; and ii) containing at least one cationic group, with a cationic degree of substitution (DScat.)extraction, from about 0.20 to about 0.30.Type: ApplicationFiled: July 20, 2012Publication date: June 5, 2014Applicant: RHODIA OPERATIONSInventors: Gilda Lizarraga, Delphine Mechineau, Dominique Lemos, Caroline Mabille
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Publication number: 20140147904Abstract: The present invention relates to a filtering apparatus and method for mixing a compound of solid and fluid phases, separating the phases and/or extracting fluid from the compound. One embodiment of the invention discloses a filtering apparatus comprising a first filter section accommodating a first group of filter members, and a second filter section accommodating a second group of filter members, a piping system providing pipelined fluid communication between the filter sections and between a filter section and said filter section's corresponding group of filter members, the piping system configured such that the filter members form filtered fluid openings of the filtering apparatus, and circulation means, such as a pump, configured for passing fluid in a forward flow and/or in a reverse flow between the filter sections. In particular the invention may be used for the mashing process in a beer brewing procedure.Type: ApplicationFiled: August 13, 2012Publication date: May 29, 2014Applicant: TECHNICAL UNIVERSITY OF DENMARKInventors: Peter Stubbe, Preben Bøje Hansen
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Publication number: 20140147407Abstract: The present invention discloses a matrix comprising a modified primary hydroxyl groups containing polysaccharide comprising repeating disaccharide units wherein in at least part of the disaccharide units the primary hydroxyl group is replaced by functional groups selected from halide groups or groups comprising sulfur or phosphorus atoms, like e.g. sulfate groups, sulfonate groups, phosphonate groups and phosphate groups.Type: ApplicationFiled: November 20, 2013Publication date: May 29, 2014Inventors: V. Prasad SHASTRI, Aurelien FORGET, Florian MIESSMER
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Publication number: 20140147471Abstract: Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type II arabinogalactan compounds and utilising this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.Type: ApplicationFiled: November 12, 2013Publication date: May 29, 2014Applicant: COMVITA NEW ZEALAND LTD.Inventors: Ian Sims, Jonathan McDonald Counsell Stephens, Ralf Christian Schlothauer, Swapna Gannabathula
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Publication number: 20140148592Abstract: The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.Type: ApplicationFiled: February 3, 2014Publication date: May 29, 2014Inventors: A. Stewart CAMPBELL, Gregory LOHMAN, Obadiah J. PLANTE