Chitin Or Derivative Patents (Class 536/20)
  • Patent number: 10487190
    Abstract: The present invention discloses a versatile, macroporous, omniphilic polymeric sponges for absorption of organic liquids of varying polarity as well as water. Particularly, disclosed herein is an ice-templated macroporous omniphilic polymeric sponge as inexpensive versatile absorbents.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 26, 2019
    Assignee: Council of Scientific & Industrial Research
    Inventors: Guruswamy Kumaraswamy, Soumyajyoti Chatterjee, Sayam Sen Gupta
  • Patent number: 9962401
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: May 8, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Yoon Yeo, Gaurav Bajaj, Peisheng Xu, Karen Liu, Eun Jung Cho
  • Patent number: 9914787
    Abstract: A new generation elastomeric biopolymer produced by yeast belonging to the family Saccharomycetaceae, and an isolated yeast belonging to the genus Williopsis that produces and secretes the biopolymer.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: March 13, 2018
    Assignee: Arrowhead Center, Inc.
    Inventors: Geoffrey Battle Smith, David C. Johnson, Shuguang Deng, Nagamany Nirmalakhandan
  • Patent number: 9846163
    Abstract: The invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of N-deacetylation (DDA) of between about 15% and 40%. The compositions are typically bioabsorbed in about 90 days or less and can be made to bioabsorb at differing rates of speed. The compositions are initially soluble in aqueous solution below pH 6.5. The compositions have an acid content that can be adjusted between about 0% (w/w) and about 8% (w/w) to customize the composition for uses that require and/or tolerate differing levels of cytotoxicity, adhesion, composition cohesion, and cell infiltration into the composition.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: December 19, 2017
    Assignee: Tricol Biomedical, Inc.
    Inventors: Barbara McGrath, Simon McCarthy, Sam Kuhn, Alysha Wold, Michael Stolten, Amanda Bennett
  • Patent number: 9816363
    Abstract: A method of treating a subterranean formation. The method may include providing a well treatment including a treatment complex formed of a treatment agent encapsulated, entrapped, or embedded in a polysaccharide, introducing the treatment complex into a wellbore through a subterranean formation, and allowing the treatment complex to release the treatment agent over a release time period. The method may include allowing the treatment complex to release the treatment agent after a delay time period from the introduction of the treatment complex into the wellbore.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: November 14, 2017
    Assignee: Superior Energy Services, LLC
    Inventors: Sumitra Mukhopadhyay, Chad Williams, Bernard Franklin, Eddie G. Bowen
  • Patent number: 9801812
    Abstract: An injectable non-aqueous composition and a method of treating a vascular disease, the non-aqueous composition including: chitosan having a particle size of no greater than 50 ?m; alginate having a particle size of no greater than 50 ?m; and a non-aqueous carrier; wherein upon combination and injection into the vascular system of a subject, the composition causes a diseased portion of the vascular system to be absorbed into surrounding tissue.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: October 31, 2017
    Assignee: Covidien LP
    Inventors: Gaurav Girdhar, Xiaodong Ma, Jennifer Makridakis
  • Patent number: 9795717
    Abstract: Enzymatically degradable compositions containing biocompatible polymers reactive with glycosaminoglycan compositions having a first glycosaminoglycan compound having a first degree of acetylation and a second glycosaminoglycan compound having a second degree acetylation different than the first degree of acetylation.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: October 24, 2017
    Assignee: Sofradim Production
    Inventor: Sébastien Ladet
  • Patent number: 9655842
    Abstract: An injectable non-aqueous composition and a method of treating a vascular disease, the non-aqueous composition including: chitosan having a particle size of no greater than 50 ?m; alginate having a particle size of no greater than 50 ?m; and a non-aqueous carrier; wherein upon combination and injection into the vascular system of a subject, the chitosan and alginate form a polyelectrolyte gel in situ.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 23, 2017
    Assignee: Covidien LP
    Inventors: Gaurav Girdhar, Xiaodong Ma
  • Patent number: 9644040
    Abstract: The present disclosure relates to hyaluronic acid derivatives, and in particular, derivatives in which the N-acetyl group of hyaluronic acid has been substituted, and methods and uses thereof.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 9, 2017
    Assignee: Anacoti Ltd.
    Inventor: Tassos Anastassiades
  • Patent number: 9567406
    Abstract: A method for obtaining an elongate polysaccharide element, in particular a chitosan thread, includes extruding a hydroalcoholic extrusible solution containing a polyalcohol of said polysaccharide through an extrusion die, coagulating the extruded solution by neutralization, and at least one operation of removing the polyalcohol. The ratio of water to polyalcohol in the extrusible solution is determined such as to obtain in the elongate element a polysaccharide with the crystalline structure thereof mainly in the form of an anhydrous allomorph. Since the polysaccharide used to prepare the extrusible solution has a weight-average molar mass Mw0, the polysaccharide in the elongate element obtained preferably has a weight-average molar mass Mw1 comprised between Mw0 and 0.7 Mw0. Since the purpose is to obtain a chitosan thread, the latter has properties of mechanical strength and flexibility that allow the thread to be tied into overhand knots and to be woven without breaking.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: February 14, 2017
    Assignees: LABORATOIRE TETRA MEDICAL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON I
    Inventors: Laurent David, Alexandra Montembault, Mylène Desorme
  • Patent number: 9387206
    Abstract: The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: July 12, 2016
    Assignee: PHARNEXT
    Inventors: Daniel Cohen, Ilya Chumakov, Serguei Nabirochkin
  • Patent number: 9370451
    Abstract: A medical device for delivery of a therapeutic agent to a physiological target site includes a flexible receptacle containing said therapeutic agent, wherein at least a part of the receptacle is formed of a water-soluble or water-dispersible material. The therapeutic agent may include a haemostatic agent and the physiological target site may be a wound.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: June 21, 2016
    Assignee: MEDTRADE PRODUCTS LIMITED
    Inventors: Craig Julian Hardy, Stewart Andrew Darby, Andrew Guy Eason
  • Patent number: 9259434
    Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: February 16, 2016
    Assignee: Endomedix, Inc.
    Inventors: Weiliam Chen, John M. Abrahams
  • Patent number: 9234050
    Abstract: Described herein are methods of inhibiting the growth of or killing a bacterium in an animal subject, preventing or delaying onset of an infection with a bacterium in an animal subject, preventing or delaying onset of a pathogen mediated disease or disorder in an animal subject, or reducing bacterial load in an animal subject, comprising administering an effective amount of a derivatized chitosan to the animal. Also described herein are preparations comprising a chitosan derivative for administration to an animal.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: January 12, 2016
    Assignee: SYNEDGEN, INC.
    Inventors: Shenda M. Baker, William P. Wiesmann
  • Patent number: 9199000
    Abstract: The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes. In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 1, 2015
    Assignee: Nanyang Technological University
    Inventors: Chan Bee Eng Mary, Poon Yin Fun, Mouad Lamrani, Shinichi Hamaguchi
  • Patent number: 9169376
    Abstract: A composite includes particles of thermoplastic polymer coated with a chitin nanowhisker gel and melt-blended. The thermoplastic polymer may be polystyrene, polyethylene, acrylonitrile butadiene styrene, polycarbonate, or another thermoplastic polymer. A method of processing chitin includes forming a non-colloidal mixture substantially of chitin and hydrochloric acid to subject the chitin to hydrolysis; upon the mixture becoming substantially colloidal, controlling conditions of the mixture to slow the hydrolysis; dialyzing the substantially colloidal mixture to produce a processed colloidal mixture consisting substantially of water and crystalline chitin; and reducing amount of agglomerated crystalline chitin and water in the processed colloidal mixture thereby to yield chitin nanowhisker gel.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: October 27, 2015
    Assignee: Boco Technology Inc.
    Inventor: Qi Guan
  • Patent number: 9139663
    Abstract: The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to treat wounds. More specifically the present invention relates to hemostatic compositions that reduce the need for, and cost of, nursing care of patients with chronic wounds by reducing the frequency of wound dressing changes.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: September 22, 2015
    Assignee: MARINE POLYMER TECHNOLOGIES, INC.
    Inventors: Sergio Finkielsztein, John N. Vournakis
  • Patent number: 9126375
    Abstract: Valve-through tire puncture sealant compositions including dissolved and undissolved natural bio-materials, anti-freezing agents and other rigid particles are invented. In the preparation, an aqueous solution with 0.1-10 wt % dissolved bio-materials and 0.1%-10 wt % tackifier is mixed with anti-freezing agent, in which 0.01-5 wt % rigid particles of bio-materials and other particles are suspended. Weight percentage of water and anti-freezing agent are 20-40 wt % and 20-70 wt % respectively. Trace amounts of additives such as coloring and preservative are possibly added to the sealant. The invention includes the method for preparing the sealant composition containing bio-materials. The proposed sealant compositions have several advantages: Environmentally friendly, insignificant settling, long shelf-life, etc. The sealant is capable of sealing puncture formed by less than or equal to 6.35 mm spike for long duration, i.e. more than 30 hours.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: September 8, 2015
    Assignee: Top Alliance Technology Limited
    Inventors: Koon Fung Lam, Wai Ming Chan
  • Publication number: 20150144563
    Abstract: Articles containing soil adsorbing polymers, and more particularly, articles, for example nonwovens, such as paper towels, wovens, and/or sponges and/or article-forming components thereof that comprise a durably bonded soil adsorbing polymer, article-forming components used to make such articles, and processes for making same are provided.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 28, 2015
    Inventors: Robin Lynn McKIERNAN, Robert Joseph McCHAIN, Steven Daryl SMITH
  • Publication number: 20150135644
    Abstract: A wound dressing comprising acylated chitosan fibre. The dressing has a wet strength of 0.3 N/cm or above. The acylated chitosan fibre may have a degree of substitution of 0.10-0.50. The acylated chitosan fibre may preferably have a degree of substitution of 0.20-0.40. The dressing may have an absorbency of 5-25 g/g of a solution containing 8.298 g/l of sodium chloride and 0.368 g/l of calcium chloride dehydrate as measured by BSEN 13726-12002 Part 1 Aspects of Absorbency. The base material of the dressing may be chitosan fibre that has been chemically modified through an acylation process using anhydride and ethanol as the solvent. A method of manufacturing the wound dressing involves reacting chitosan fibre with anhydride and making acylated chitosan felt through a nonwoven process, and through cutting, packing and sterilizing processes.
    Type: Application
    Filed: January 17, 2012
    Publication date: May 21, 2015
    Inventors: Xiaohui Mo, Xiaodong Wang, Zhenjun Wu
  • Publication number: 20150139870
    Abstract: Microporous glutaraldehyde-crosslinked chitosan sorbents, methods of making and using them, and a generator for the radioisotope 99Mo containing the sorbents.
    Type: Application
    Filed: November 19, 2014
    Publication date: May 21, 2015
    Applicant: PERMA-FIX ENVIRONMENTAL SERVICES, INC.
    Inventor: Shameem HASAN
  • Publication number: 20150132433
    Abstract: Methods for producing insect product are provided that include wet-grinding at least one whole insect into an insect slurry and drying the insect slurry to form a dried insect product comprising solid insect matter particles. Methods for producing a chitin product are also provided that include wet-grinding at least one whole insect into an insect slurry and removing chitin from at least a portion of the insect slurry. Insect products are also provided that include a composition derived from at least one whole insect and has solid insect matter particles, in which the composition has a peroxide value of about 30 meq/kg of fat or less and about 90% of the solid insect matter particles, by volume, has a particle size of about 1000 ?m or less.
    Type: Application
    Filed: November 11, 2014
    Publication date: May 14, 2015
    Inventor: Aaron T. Dossey
  • Patent number: 9018372
    Abstract: The invention relates to a bonding product comprising at least the polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are constructed are partially or completely bonded to each other alpha-1,4-glycosidically and b) at least one of the polysaccharides T1 and/or T2 comprises at least one amino group and c) T1 and T2 are chemically bonded to each other covalently by at least one linker Z and d) T1 and/or T2 carries m groups -(L-A), wherein A is an active pharmaceutical ingredient and/or a fluorescence label, L is a second linker, by which T1 and/or T2 is covalently bonded to A, and m is an integer, which is 0 or at least 1.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: April 28, 2015
    Assignee: B. Braun Melsungen AG
    Inventors: Bernd Horst Meier, Iris Jankowiak-Meier, Nele Meier, Clara Meier
  • Patent number: 8986728
    Abstract: The present invention provides an implantable device having a biosoluble coating or a biosoluble body structure comprising a polyelectrolyte and a counterion and the methods of making and using the same.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: March 24, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Mikael O. Trollsas, Lothar W. Kleiner
  • Publication number: 20150080335
    Abstract: The present invention relates to a process for producing a low endotoxin alkali chitosan, and also to a process for producing low endotoxin neutral chitosan, chitosan salt and chitosan derivatives, and to the products of such processes. The process comprises contacting chitosan with an alkali solution to form a mixture and leaving the mixture for at least about 12 hours. The low endotoxin alkali chitosan may be used in the manufacture of other useful chitosan based products.
    Type: Application
    Filed: March 25, 2013
    Publication date: March 19, 2015
    Inventors: June Gladman, Craig Hardy, Andrew Hoggarth
  • Patent number: 8980238
    Abstract: Because of the formation of disulfide bridges with mucus glycoproteins, the mucoadhesive properties of polymeric compounds can be significantly improved by the covalent attachment of thiol substructures to them. By the transformation of free thiol groups on such polymers in disulfides with mercaptonicotinamides or mercaptopyridoxins these thiol groups become comparatively more reactive resulting in significantly improved mucoadhesive properties. Furthermore, polymers exhibiting disulfide partial structures with mercaptonicotinamides or mercaptopyridoxins do not need to be protected against oxidation. In addition, they show comparatively higher permeation enhancing properties.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: March 17, 2015
    Assignees: Thiomatrix Forschungs—Und Beratungs GmbH, Croma Pharma GmbH
    Inventor: Johannes Leierer
  • Patent number: 8975387
    Abstract: Compositions of matter are provided that include chitosan and a modified carbohydrate. The modified carbohydrate includes a carbohydrate component and a cross linking agent. The modified carbohydrate has increased carboxyl content as compared to an unmodified counterpart carbohydrate. A carboxyl group of the modified carbohydrate is covalently bonded with an amino group of chitosan. The compositions of matter provided herein may include cross linked starch citrate-chitosan and cross linked hemicellulose citrate-chitosan, including foams thereof. These compositions yield excellent absorbency and metal chelation properties. Methods of making cross linked modified carbohydrate-chitosan compounds are also provided.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: March 10, 2015
    Assignee: North Carolina State University
    Inventors: Richard A. Venditti, Joel J. Pawlak, Abdus Salam, Khaled Fathy El-Tahlawy
  • Patent number: 8961592
    Abstract: At least some embodiments of the invention relates to an implant having a coating that contains or is composed of a functionalized RGD peptidomimetic RGD-P1 having the formula (1) and/or a functionalized RGD peptidomimetic RGD-P2 having the formula (2), and an associated manufacturing method.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: February 24, 2015
    Assignee: Biotronik AG
    Inventors: Alexander Borck, Matthias Gratz, Horst Kessler, Michael Joner, Florian Rechenmacher, Stefanie Neubauer
  • Publication number: 20150051265
    Abstract: Provided herein is chitosan dually derivatized with arginine and gluconic acid; and methods of making and using the same, e.g., for gene delivery in vivo.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 19, 2015
    Inventors: Jun Gao, Eric Hsu, Anthony Cheung
  • Patent number: 8951565
    Abstract: Improved hemostatic agents take the form of granules or particles that can be used to stanch, seal, or stabilize a site of hemorrhage, including a noncompressible hemorrhage.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: February 10, 2015
    Assignee: HemCon Medical Technologies, Inc.
    Inventor: Simon J. McCarthy
  • Patent number: 8940881
    Abstract: The present invention provides a method for producing chitin nanofibers, which includes the steps of deproteinizing a material derived from a chitin-containing organism by an alkali treatment, deashing a deproteinized integument by an acid treatment, optionally treating the deashed integument under acidic conditions, and then subjecting to a fiber-loosening treatment. The present invention also provides chitin nanofibers obtained by the method, and a composite material and a coating composition each containing the same. The present invention provides a method for producing chitosan nanofibers, which includes, in addition to the above steps, a deacetylation step and chitosan nanofibers obtained by the method, and a composite material and a coating composition each containing the same.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: January 27, 2015
    Assignees: Tottori University, Kyoto University, Omura Toryo Co., Ltd.
    Inventors: Shinsuke Ifuku, Hiroyuki Saimoto, Hiroyuki Yano, Masaya Nogi, Yoshihiko Omura
  • Publication number: 20150018748
    Abstract: The present invention relates generally to therapeutic compositions comprising chitosan-derived compositions used in connection with methods for treating neoplasms, such as for instance, malignant lung, thyroid and kidney neoplasms, and other types of malignant neoplasms, and other medical disorders.
    Type: Application
    Filed: January 17, 2013
    Publication date: January 15, 2015
    Applicant: IMMUNOPHOTONICS, INC.
    Inventors: Tomas Hode, Robert E. Nordquist, Wei R. Chen, Raoul Carubelli, Luciano Alleruzzo, Peter Jenkins, Kristopher Waynant, Joseph Raker
  • Patent number: 8932560
    Abstract: A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
    Type: Grant
    Filed: September 4, 2008
    Date of Patent: January 13, 2015
    Assignees: University of Maryland, College Parke, University of Maryland, Baltimore
    Inventors: Matthew Dowling, John Hess, Grant Bochicchio, Srinivasa Raghavan
  • Publication number: 20150011742
    Abstract: The present disclosure provides methods for producing chitosan derivatives and the derivatives formed by these methods. The processes of the present disclosure utilize electrochemical methods to functionalize and/or modify amine and/or hydroxyl groups present on chitosan, to form new derivatives. In embodiments, a chloro-chitosan derivative may be prepared. The altered cationic affinity of these derivatives make them excellent candidates for biomedical applications, including pharmaceuticals, as well as food applications.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 8, 2015
    Inventors: Gary P. Halada, Prashant Kumar Jha
  • Publication number: 20150011684
    Abstract: A composite includes particles of thermoplastic polymer coated with a chitin nanowhisker gel and melt-blended. The thermoplastic polymer may be polystyrene, polyethylene, acrylonitrile butadiene styrene, polycarbonate, or another thermoplastic polymer. A method of processing chitin includes forming a non-colloidal mixture substantially of chitin and hydrochloric acid to subject the chitin to hydrolysis; upon the mixture becoming substantially colloidal, controlling conditions of the mixture to slow the hydrolysis; dialyzing the substantially colloidal mixture to produce a processed colloidal mixture consisting substantially of water and crystalline chitin; and reducing amount of agglomerated crystalline chitin and water in the processed colloidal mixture thereby to yield chitin nanowhisker gel.
    Type: Application
    Filed: July 5, 2013
    Publication date: January 8, 2015
    Inventor: Qi Guan
  • Publication number: 20150004257
    Abstract: A polymeric composition capable of releasing nitric oxide and modulating biological responses comprises a biocompatible polymer and S-nitrosated thiol bonded to the biocompatible polymer. The polymeric composition can have a thiol conversion of at least 40%. The polymeric composition can also have a nitric oxide recovery of at least 40% when under thermal decomposition conditions.
    Type: Application
    Filed: February 23, 2012
    Publication date: January 1, 2015
    Applicant: Colorado State University Research Foundation
    Inventors: Melissa M. Reynolds, Vinod B. Damodaran
  • Publication number: 20140378413
    Abstract: Modified chitosan hemostatic agents include reverse micelles (10) having an outer hydrophobic shell (12) of suitable biocompatible hydrophobic components such as alkanes, and hydrophilic positively charged chitosan moieties (14) enclosed within the hydrophobic shell (12). The hydrophobic shell (12) may be formed by attaching hydrophobic moieties to one end of chitosan polymer molecules while retaining sufficient reactive (positively charged) amine groups on the remainder of the chitosan polymers for effective blood clotting. The resulting reverse micelles (10) have the capability of penetrating mucous membranes such as nasal mucosa (20) or otherwise penetrating to bleed sites shielded or partially shielded by mucosa or other tissues.
    Type: Application
    Filed: September 5, 2014
    Publication date: December 25, 2014
    Inventors: Dean A. Berman, Joseph Bristow
  • Patent number: 8916693
    Abstract: Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly(ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugates are also provided. Related methods, intermediates, and compositions are also provided.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: December 23, 2014
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Antoni Kozlowski, Patrick D. Youso
  • Publication number: 20140363673
    Abstract: The present invention provides a therapeutic and/or prophylactic agent for inflammatory bowel disease and an NF-kB activation inhibitor, each of which comprises chitin nanofibers or chitosan nanofibers.
    Type: Application
    Filed: June 27, 2012
    Publication date: December 11, 2014
    Applicants: National University Corporation Tottori University, Tottori Prefectural Government
    Inventors: Saburo Minami, Kazuo Azuma, Tomohiro Osaki, Shinsuke Ifuku, Hiroyuki Saimoto
  • Publication number: 20140350091
    Abstract: The invention provides highly concentrated chitosan-nucleic acid polyplex compositions and dispersions, and methods for producing the compositions and dispersions. Methods of mixing the chitosan-nucleic acid polyplexes include an inline mixing of chitosan solution and nucleic acid solution, followed by further concentrating the dispersion of chitosan-nucleic acid polyplexes, optionally with an aggregation inhibitor. Further provides are methods for altering the diameter of chitosan-nucleic acid polyplexes.
    Type: Application
    Filed: April 30, 2014
    Publication date: November 27, 2014
    Applicant: enGene, Inc.
    Inventors: Eric HSU, Carlos FLEET, Anthony CHEUNG, Jun GAO
  • Patent number: 8877170
    Abstract: The present disclosure relates to implantable medical devices having a non-bioabsorbable substrate and an amphiphilic coating covalently bonded to the substrate for reducing the inflammatory response to the device after implantation.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: November 4, 2014
    Assignee: Sofradim Production
    Inventors: Sebastien Ladet, Philippe Gravagna
  • Patent number: 8877907
    Abstract: Disclosed is a cross-linked molecularly imprinted polymer including cross-linked chitosan having selective binding sites for phosphate ions, phosphate containing molecules, or a combination of both.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: November 4, 2014
    Assignee: The Johns Hopkins University
    Inventors: Tracy J. Terry, Andrew F. Mason, Carl A. Marrese
  • Publication number: 20140323433
    Abstract: Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Inventors: Matthew F. Myntti, Dana A. Oliver, Brian J. Vaccaro
  • Publication number: 20140316361
    Abstract: A process for producing a salt of a chitosan acid anion derivative, which comprises contacting chitosan fibre (a) with a base in an aqueous or non-aqueous medium and (b) with a solution in an aqueous or non-aqueous medium of a salt of the formula (I): M-R-T wherein M is a Group IA metal cation; R is a hydrocarbyl oxoacid anion, substituted by T; and T is a nucleophilic leaving group, all at a temperature below 50° C., preferably in the range of 30 to 40° C.
    Type: Application
    Filed: January 11, 2012
    Publication date: October 23, 2014
    Applicant: Medtrade Products Ltd.
    Inventor: Christian Stephenson
  • Patent number: 8865878
    Abstract: This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: October 21, 2014
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Saul Yedgar
  • Patent number: 8865879
    Abstract: The present invention pertains to chitosan beads consisting of chitosan cross-linked with citrate ions. The present invention furthermore pertains to a filler comprising such chitosan-citrate beads. In one embodiment of the instant invention the filler is a dermal filler. In one further embodiment of the present invention the dermal filler is for the treatment of wrinkles and/or folds. In another embodiment of the instant invention the filler is for use in the treatment of a medical condition. The filler provided in the present invention may further comprise one or more active pharmaceutical ingredients. Further, the present invention pertains to a process for preparing the filler as claimed herein.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: October 21, 2014
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Kevin Kiehm, Bernhard Hauptmeier, Peter Boderke
  • Publication number: 20140308236
    Abstract: The present invention provides a composition including an antibacterial polymer bound to a synthetic water soluble polymer, methods of using the composition for avoiding bacterial growth and processes of making plastic material which include these antibacterial compositions.
    Type: Application
    Filed: January 2, 2014
    Publication date: October 16, 2014
    Inventors: Havazelet BIANCO-PELED, Maya DAVIDOVICH-PINHAS
  • Publication number: 20140309410
    Abstract: The present invention relates to an amine grafted chitosan nanofiber having the formula (I) wherein R1 to R5 are independently selected from linear or branched C1-C20 alkandiyl C6-C24 arenediyl; k and m are independently selected from 1 to 10, wherein, in case that k and/or m are >1, each R4 and R5 group can be independently selected; and 1 and n are independently selected from 50-3000, a method for the preparation thereof and its use in heavy metal adsorption.
    Type: Application
    Filed: February 21, 2014
    Publication date: October 16, 2014
    Applicant: King Saud University
    Inventors: Sajjad HAIDER, Yousef S. AL-ZAGHAYER, Waheed AL-MASRY, Fekri Abdulraqeb Ahmed Ali, Mohammed K. HADJ-KALI
  • Patent number: 8859724
    Abstract: The invention relates to a bonding product suitable as a carrier for medicinal substances and to the compound derived therefrom that carries medicinal substances. The invention further relates to a process and device for preparing such bonding products and compounds. Further, the invention relates to a pharmaceutical composition containing such bonding products and compounds, and to the use thereof for preparing an infusible medicament for treating a disease.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: October 14, 2014
    Assignee: B. Braun Melsungen AG
    Inventors: Bernd H. Meier, Nele Meier
  • Publication number: 20140303361
    Abstract: Processes for the synthesis of lipochitooligosaccharides were developed. A fully acylated oligoglucosamine precursor is prepared and reacted with a glucosamine monomer that has an amine protecting phthaloyl group. With removal of the phthaloyl group, a fatty acid may be added on the terminal glucosamine unit, forming a lipochitooligosaccharide. The processes can be adapted for use on a commercial scale.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventor: Subramaniam Sabesan