Chitin Or Derivative Patents (Class 536/20)
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Publication number: 20100272761Abstract: The present disclosure provides polymer compounds binding with lipoamide produced by the reaction of the primary amine group of lipoamide with the carboxy group of polysaccharide compounds such as chondroitin sulfates, carboxymethyl celluloses, or hyaluronic acids; functional compounds such as peptides, proteins, growth factors; or drugs; or biocompatible polymers such as poly(ethylene oxide), poly(vinyl alcohol), or poly(vinyl pyrrolidone). The present disclosure also provides their synthesis methods, products of hydrogels and films using the same as and methods for manufacturing the products.Type: ApplicationFiled: October 29, 2009Publication date: October 28, 2010Applicant: Seoul National University of Technology Center for Industrial CollaborationInventors: Insup NOH, Seongyeun JO, Doyeon KIM, Junghoon WOO
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Publication number: 20100273994Abstract: The invention relates to novel hybrid compounds containing at least one polysaccharide entity (PS), such as guar, in which at least one hydroxyl function is substituted by at least one A polyoxyalkylene entity (PEG). The swivel Ro between the entity PS and the entity A is obtained by click chemistry and has the following formula (II.1) or (II.2), in which Z is a carbon or nitrogen atom. These hybrid compounds can be used as emulsifiers, particularly in cosmetics.Type: ApplicationFiled: November 14, 2008Publication date: October 28, 2010Applicant: Rhodia OperationsInventors: Etienne Fleury, Morgan Tizzotti, Mathias Destarac, Marie-Pierre Labeau, Thíerry Hamaide, Eric Drockenmuller
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Publication number: 20100272813Abstract: The present invention provides nanoparticles for treatment of inflammatory diseases. The nanoparticles preferably comprise chitosan and a siRNA targeting a mRNA encoding a pro-inflammatory cytokine, such as e.g. tnf-alfa. A preferred route of administration of the nanoparticles is by injection intraperitoneally.Type: ApplicationFiled: July 23, 2008Publication date: October 28, 2010Applicant: AARHUS UNIVERSITETInventors: Jørgen Kjems, Kenneth Alan Howard, Flemming Besenbacher, Bent Deleuran
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Patent number: 7820872Abstract: A chitosan biomaterial is frozen in aqueous solution to form a frozen chitosan structure from which water is removed by a prescribed freeze-drying process to form a sponge-like chitosan structure having a thickness and a density. The sponge-like chitosan structure is compressed by application of heat and pressure to reduce the thickness and increase the density of the sponge-like chitosan structure to form a densified chitosan structure. The densified chitosan structure is further preconditioned by heating the densified chitosan structure according to prescribed conditions to form a wound dressing. The wound dressing possesses an adhesion strength and resistance to dissolution in high blood flow bleeding situations.Type: GrantFiled: October 31, 2007Date of Patent: October 26, 2010Assignee: Providence Health System-OregonInventors: Kenton W Gregory, Simon McCarthy
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Publication number: 20100266784Abstract: Thermosetting polymeric compositions, such as polyurethane compositions, and related methods are provided. The invention relates to coating and polymer compositions and related methods derived from a biodegradable natural polysaccharide compound such as chitosan, pectin, heparin, and combinations thereof reacted to a cyclic oxide compound, such as an oxetane, oxolane or oxepane compound. The compositions and methods of the present invention exhibit self-repairing properties upon exposure to ultraviolet (UV) light. The compositions and methods of the present invention can be used in many coating applications, such as the transportation, packaging, fashion, and biomedical industries.Type: ApplicationFiled: March 12, 2010Publication date: October 21, 2010Inventors: Marek W. Urban, Biswajit Ghosh
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Publication number: 20100266681Abstract: The present invention relates to a lipid composition comprising at least omega-3 polyunsaturated alcohols, or pro-drugs thereof, which omega-3 polyunsaturated alcohols, or pro-drugs thereof, comprising at least (all-Z)-5,8,11,14,17-eicosapentaen-1-ol, or pro-drug thereof, and (all-Z)-4,7,10,13,16,19-docosahexaen-1-ol, or pro-drug thereof, and their use as a pharmaceutical, in particular for the treatment of elevated triglyceride levels. The invention also relates to methods for the preparation of these pro-drugs from marine oils.Type: ApplicationFiled: November 2, 2007Publication date: October 21, 2010Inventor: Anne Kristin Holmeide
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Publication number: 20100261136Abstract: The invention relates to a dental composition comprising a hardenable powder to be used in a process for retraction of dental tissue. The invention also relates to a kit of parts comprising the dental composition comprising a hardenable powder, a hardening agent, optionally a handpiece of a powder jet device, optionally a powder jet device, and optionally retraction caps. In a further aspect, the invention relates to a method for retracting dental tissue comprising the steps of applying a dental composition comprising a hardenable powder with a powder jet device into the sulcus between soft and hard dental tissue, applying a composition comprising a hardening agent either before or after the previous step, leaving the dental composition in the sulcus for a time sufficient to effect retraction of the soft dental tissue and removing the dental composition from the sulcus.Type: ApplicationFiled: December 9, 2008Publication date: October 14, 2010Inventors: Christoph Schulte, Andreas R. Maurer, Thomas Klettke, Ruediger Hampe, Ingo R. Haeberlein
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Publication number: 20100261780Abstract: The invention provides highly acidic chitosan-nucleic acid polyplex compositions. The compositions may be used to transfect cells in vitro and in vivo, and are particularly useful for transfecting cells of mucosal epithelia.Type: ApplicationFiled: March 31, 2010Publication date: October 14, 2010Applicant: enGene, Inc.Inventors: Jun GAO, Carlos Fleet, Eric Hsu, Anthony Cheung
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Patent number: 7811999Abstract: This invention provides a method of treating a subject suffering from an obstructive respiratory disease, including the step of administering to a subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from an obstructive respiratory disease.Type: GrantFiled: November 17, 2004Date of Patent: October 12, 2010Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.Inventors: Saul Yedgar, David Shoseyov
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Publication number: 20100255097Abstract: Disclosed are polysaccharides containing residues of glucosamine or galactosamine in the repetitive unit, characterised by the presence of esters on the hydroxyls or amides on the amine functions, with lipoic acid or with mixtures of lipoic acid and formic acid.Type: ApplicationFiled: December 11, 2008Publication date: October 7, 2010Applicant: SIGEA S.R.L.Inventors: Fabrizio Picotti, Marco Bosco, Luca Stucchi, Matteo Fabbian
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Publication number: 20100216972Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.Type: ApplicationFiled: April 30, 2010Publication date: August 26, 2010Inventors: Gino VAN HEEKE, Emma HICKMAN, Henry Luke DANAHAY, Pamela TAN, Anke GEICK, Hans-Peter VORNLOCHER
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Publication number: 20100216971Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.Type: ApplicationFiled: April 30, 2010Publication date: August 26, 2010Inventors: Gino VAN HEEKE, Emma HICKMAN, Henry Luke DANAHAY, Pamela TAN, Anke GEICK, Hans-Peter VORNLOCHER
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Patent number: 7776840Abstract: This invention relates to the use of a biomaterial for the treatment, repair and/or enhancement of bodily tissue insufficiencies of the vocal chords, muscles, ligaments, cartilage, post-operative regions, sexual organs and/or weight supporting areas of the feet as well as other conditions of the bones and joints. The biomaterial for use in the invention may comprise an injectable bioresorbable polysaccharide composition wherein the polysaccharide may be succinochitosan glutamate. This invention also relates to the use of a biomaterial comprising an injectable bioresorbable polysaccharide composition in which resorbable particles may be in suspension, the said particles comprising or consisting essentially of chitin and/or chitosan, which may be free of any additional formulation modifying agents, and a process for manufacturing the same. The invention also includes the use of various medicaments in the biomaterial formulations to enhance the treatment of the affected area of the body.Type: GrantFiled: February 21, 2007Date of Patent: August 17, 2010Assignee: Cutanea Life Sciences, Inc.Inventors: Robert J. Bitterman, Kimberly A. Forbes-McKean
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Publication number: 20100204177Abstract: The invention relates to a thermosensitive (poly(ethylene oxide) poly(propylene oxide))-acetal derivative, which can be used to functionalize chitosan, and to the process for the preparation thereof. The invention therefore also relates to a process for functionalizing chitosan by grafting this thermosensitive copolymer and optionally another thermosensitive polymer, poly(ethylene oxide). A subject of the invention is also a chitosan-(poly(ethylene oxide) poly(propylene oxide))-poly(ethylene oxide) derivative which has the advantage of being water-soluble at physiological pH. The invention therefore also relates to the aqueous compositions comprising this derivative and to the use of this composition for the manufacture of gel by heating.Type: ApplicationFiled: September 11, 2008Publication date: August 12, 2010Inventors: Rachel Auzely-Velty, Caroline Creuzet
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Patent number: 7772196Abstract: This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes the step of administering to a subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, oligomer, or polymer, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof, in an amount effective to treat the subject suffering from a dermatologic condition.Type: GrantFiled: November 17, 2004Date of Patent: August 10, 2010Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Saul Yedgar
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Patent number: 7772382Abstract: Provided is a chitosan derivative having a high optical resolving power. Specifically provided is a chitosan derivative represented by the following Formula (I). wherein R1 represents an aliphatic group or an aromatic group having a carbon number of 1 to 30 which may have a substituent; R2 represents a substituent originating from an isocyanic acid derivative, carboxylic acid, ester, acid halide, acid amide compound, halide compound, aldehyde, or alcohol; and n is an integer of 5 or more.Type: GrantFiled: April 28, 2006Date of Patent: August 10, 2010Assignees: National University Corporation Nagoya University, Daicel Chemical Industries, Ltd.Inventors: Yoshio Okamoto, Chiyo Yamamoto, Masami Kamigaito
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Patent number: 7767456Abstract: The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP)<10 in addition to a weight fraction of less than 20% with DP>50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.Type: GrantFiled: June 1, 2007Date of Patent: August 3, 2010Assignee: FMC Biopolymer ASInventors: Per Artursson, Bjorn Erik Christensen, Magnus Koping-Hoggard, Kjell Morten Varnum
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Publication number: 20100190969Abstract: Non-naturally occurring carbohydrate-based fibrous elements and more particularly, non-naturally occurring carbohydrate-based fibrous elements having a macrostructure and a microstructure wherein the microstructure is visible when wet and methods for making same are provided.Type: ApplicationFiled: January 21, 2010Publication date: July 29, 2010Inventor: Dean Van Phan
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Publication number: 20100168407Abstract: The invention relates to a novel kind of chitosan derivative, specifically to quaternized carboxymethyl chitosand derivatives and preparation method. Chitosan with different molecular weight reacts with chloroactic acid give rise to carboxymethyl chitosan. After reaction of Schiff based, deoxidized and quaternized, quaternized carboxymethyl chitosan is obtained. This kind of chitosan derivative have better water-solubility and better antifungal activity, which can used in the fields of medicine and agriculture.Type: ApplicationFiled: July 24, 2006Publication date: July 1, 2010Applicant: Institute of OCeanology Chinese Academy of SciencesInventors: Pengcheng Li, Zhanyong Guo, Song Liu, Ronge Xing, Huahua Yu, Pibo Wang, Xiaolin Chen, Cuiping Li
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Publication number: 20100160167Abstract: The present invention relates to synthetic compounds that are active on plants, especially as legume nodulation factors, and also as plant growth stimulators, and to methods for preparing such compounds, which are of formula (I): “Veuillez inserer la formule chimique de la version papier” (I)Type: ApplicationFiled: September 30, 2009Publication date: June 24, 2010Applicants: Bayer CropScience S.A., Institut National de la Recherche Agronomique, Centre National de la Recherche ScientifiqueInventors: Jean-Marie Beau, Jean Denarie, Alfred Greiner, Nathalie Grenouillat, Fabienne Maillet, Boris Vauzeilles
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Publication number: 20100160467Abstract: Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.Type: ApplicationFiled: December 10, 2009Publication date: June 24, 2010Applicant: KOREA INSTITUTE OF CERAMIC ENGINEERING & TECHNOLOGYInventors: Sang Cheon Lee, Jeong Ho Chang, Jin Hyung Lee, Kyung Ja Kim, Sung Eun Kim, Ho Chan Hwang, Ke-Won Kang, Seog-Jin Seo, Jin-Young Kim
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Patent number: 7740883Abstract: Methods are disclosed for preparing crosslinked core and core-shell nanoparticle polymers from chitosan. The final products of the present invention may be used as detergents and as additives for pharmaceutical composition and for drug delivery, and DNA carrier system. The nanoparticles made from biopolymers of the present invention may also be used in controlled release, superabsorbent materials and biomaterials like enzyme immobilization.Type: GrantFiled: March 28, 2005Date of Patent: June 22, 2010Assignee: University of DebrecenInventors: Janos Borbely, Magdolna Bodnar
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Publication number: 20100152430Abstract: A process for preparing compounds of chitosan saccharified with aminosugar, adopts chitosan derivatives, aminosugar derivatives and anhydride derivatives as raw materials to synthesize target products. The process comprises: covalently bonding an anhydride derivative as a bonding arm to an aminosugar derivative, so as to form a monosaccharide derivative having an end group of carboxyl; and then covalently bonding the monosaccharide derivative having an end group of carboxyl to a primary amino group of a chitosan derivative via the carboxyl, so as to form a compound of chitosan saccharified with aminosugar.Type: ApplicationFiled: July 8, 2009Publication date: June 17, 2010Inventors: Xiguang Chen, Jing Li, Xiaojie Cheng, Tao Jiang
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Publication number: 20100143571Abstract: The present disclosure relates to a process for preparing a substantially total lipid fraction from fresh krill, a process for separating phospholipids from the other lipids, and a process for producing krill meal.Type: ApplicationFiled: November 15, 2007Publication date: June 10, 2010Inventor: Harald Breivik
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Publication number: 20100137474Abstract: In various aspects provided are methods for producing a nanoparticle within a cross-linked, collapsed polymeric material. In various embodiments, the methods comprise (a) providing a polymeric solution comprising a polymeric material; (b) collapsing at least a portion of the polymeric material about one or more precursor moieties; (c) cross-linking the polymeric material; (d) modifying at least a portion of said precursor moieties to form one or more nanoparticles and thereby forming a composite nanoparticle.Type: ApplicationFiled: May 16, 2007Publication date: June 3, 2010Applicant: NORTHERN NANOTECHNOLOGIESInventors: Cynthia M. Goh, Jose Arnado Dinglasan, Jane B. Goh, Richard Loo, Darren Anderson
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Publication number: 20100129423Abstract: A method of biodissolving in an aqueous medium at least a part of a device, the part of the device being made of N-acetylchitosan with a degree of acetylation of more than 3% and less than 25%. In the method, the biodissolution of the part of the device is controlled by adjusting the pH of the aqueous medium in contact with the N-acetylchitosan part of the device to a value of equal or less than 6.0.Type: ApplicationFiled: April 19, 2007Publication date: May 27, 2010Applicant: MEDOVENT GMBHInventors: Thomas Freier, Rivelino Montenegro
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Publication number: 20100111860Abstract: A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.Type: ApplicationFiled: November 3, 2008Publication date: May 6, 2010Inventors: Tsai-Yueh LUO, I-Chung Tang, Jian-Wen Chen, Kwei-Luen Hsu, Yu-Lung Wu, Te-Sheng Liang, Chang-Mau Sheng, Jin-Jenn Lin, Ching-Jun Liou, Jyh-Daw Sheu
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Publication number: 20100105633Abstract: The invention relates to a process for the preparation of water-soluble chitosan salts, to chitosan products produced by this process and to their uses, e.g. in pharmaceutical or veterinary compositions or as a food or cosmetic additive. More specifically, the invention relates to a process for preparing a water-soluble chitosan salt which comprises: (a) contacting a solid chitosan with at least one protic acid whereby to produce a water-soluble chitosan salt; and (b) optionally recovering said salt, wherein said chitosan is converted into said salt whilst remaining substantially in the solid state. Gaseous or liquid protic acids may be used, including hydrochloric, acetic and propionic acids.Type: ApplicationFiled: December 20, 2007Publication date: April 29, 2010Applicant: Advanced Biopolymers ASInventors: Kjell Morton Varum, Kurt Ingar Draget, Olav Smidsrod
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Publication number: 20100098653Abstract: The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.Type: ApplicationFiled: February 29, 2008Publication date: April 22, 2010Applicant: CEDARS-SINAI MEDICAL CENTERInventors: John S. Yu, Bong Seop Lee
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Publication number: 20100093659Abstract: The present invention is directed to conjugates for biorecognition comprising (i) an carbohydrate backbone structure (PO) of 5 to 20 monosaccharide units, (ii) oligosaccharide biorecognition groups (Bio) of 1 to 10 monomer units, (iii) a bifunctional spacer groups of the formula -(y)p-(S)q-(z)r-, wherein S is a spacer group, p, q and r are each 0 or 1, whereby at least one of p and r is different from 0, and y and z are chemoselective ligation groups, which covalently link a said Bio group to said backbone structure, and the degree of conjugation, indicating the average number of covalently attached Bio biorecognition groups per monomer unit of the backbone, being from 0.2 to 1. The invention is also directed to processes for their preparation, intermediates for use in the process as well as use of said conjugates, especially for inhibiting pathogenic bacteria.Type: ApplicationFiled: December 13, 2007Publication date: April 15, 2010Applicant: GLYKOS FINLAND OYInventors: Jari Natunen, Jari Helin, Krista Weikkolainen
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Patent number: 7687249Abstract: The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5 E. coli, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.Type: GrantFiled: July 7, 2004Date of Patent: March 30, 2010Assignee: Inalco S.p.A.Inventors: Marco Manoni, Liana Salsini, Jacopo Chini, Giovanni Cipolletti
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Patent number: 7683039Abstract: The present invention is directed to a water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives and methods of preparing water soluble, randomly substituted partial N-, partial O-acetylated chitosans or chitosan derivatives comprising the steps of dissolving the chitosan or chitosan derivative into an aqueous acidic solution and reacting the chitosan or chitosan derivative with an acetylating agent in the presence of a phase transfer reagent. The present invention is further directed to a pharmaceutical preserving composition comprising: (a) at least one chitosan or chitosan derivative and (b) at least one buffer solution, as well as methods of preserving contact lens solutions and disinfecting contact lens using such composition.Type: GrantFiled: December 24, 2003Date of Patent: March 23, 2010Assignee: Adjuvant Pharmaceuticals, LLCInventors: William M. Hung, Katrina L. Bergbauer, Kai C. Su, Guigui Wang
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Publication number: 20100048483Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.Type: ApplicationFiled: August 21, 2009Publication date: February 25, 2010Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.Inventors: Guohan Yang, Ton T. Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
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Publication number: 20100040694Abstract: Disclosed are low-molecular weight, water-soluble chitosan nanoparticles with folic acid conjugated thereto as a target ligand and a preparation method thereof. The nanoparticles can be simply prepared since the strong reactivity of the chitosan allows folic acid to be readily introduced thereinto. Also, the folic acid-conjugated, low-molecular weight, water-soluble chitosan nanoparticles can be useful as gene carriers because they are of low or zero-toxicity, have sizes suitable for use as gene carriers, can readily form complexes with DNA, allow high gene expression rates, and are excellent in targeting tumor cells which are rich in folic acid receptors.Type: ApplicationFiled: November 14, 2007Publication date: February 18, 2010Applicant: KITTO LIFEInventors: Jae Woon Nah, Teok Rae Jung, Mi Kyeong Jang, Dong Gon Kim, Sun Heang Heo
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Publication number: 20100028399Abstract: The present invention relates to the use of a thiol-group-containing polymer for preparing an implant for tissue augmentation, wherein the basis polymer is a polysaccharide.Type: ApplicationFiled: December 21, 2007Publication date: February 4, 2010Applicant: CROMA-PHARMA GESELLSCHAFT M.B.H.Inventor: Margit Hornof
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Patent number: 7648969Abstract: The present invention relates to low molecular weight chitosan oligosaccharides and its preparation method. Chitosan oligosaccharides were obtained under microwave irradiation assisted the electrolyte. The method of preparing chitosan oligosaccharides was described as follows: acid solvent containing electrolyte was added to chitosan. The reaction was performed at 480˜800 W for 3˜12 min. After irradiation ceased, the reaction liquid was cooled to room temperature. Then the solution was adjusted to neutrality with 1˜10 M NaOH or KOH and obtained the pale yellow floc. The processes of precipitation, filtering, desiccation and crushing are settled sequentially. Finally, chitosan oligosaccharides were obtained. Method of the present invention makes chitosan degrade to water-soluble chitosan oligosaccharides and it makes some inert substance become active. The method of the present invention can cut down energy consumption, decrease pollution and save time and raw materials.Type: GrantFiled: October 8, 2003Date of Patent: January 19, 2010Assignee: Institute of Oceanology Chinese Academy of SciencesInventors: Pengcheng Li, Ronge Xing, Song Liu, Huahua Yu
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Patent number: 7637980Abstract: The present invention relates to agriculture. More particularly, the invention relates to a method of increasing photosynthesis of a plant and more particularly of crop plants. In addition, the invention relates to a method of increasing photosynthesis and/or yield in crop plants, comprising an exposure thereof to lipo-chitooligosaccharides, and compositions therefor. Further, the invention relates to an agricultural composition for enhancing a plant crop photosynthetic rate and/or growth thereof comprising a photosynthetic rate-promoting amount of at least one lipo chitooligosaccharide (LCO) together with an agriculturally suitable carrier and methods using same.Type: GrantFiled: July 18, 2007Date of Patent: December 29, 2009Assignee: McGill UniversityInventors: Donald L. Smith, Balakrishnan Prithiviraj, Xiaomin Zhou, Alfred Souleimanov
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Publication number: 20090311324Abstract: The present invention relates to a polymer matrix for specifically tethering surface epitopes or receptors of cells, said polymer matrix having been pretreated by molecular imprinting. The invention also relates to a method of producing such a polymer matrix. The polymer matrices according to the present invention are used in therapeutic and diagnostic applications as well as for isolating cells.Type: ApplicationFiled: August 31, 2007Publication date: December 17, 2009Applicant: KIST-Europe Forschungsgesellschaft mbHInventors: Ute Steinfeld, Barbara Palm, Hyeck Hee Lee
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Publication number: 20090300832Abstract: Chitosan films that have been treated with a polyhydroxyalkyl compound and washed, and laminates made from the films are provided. This treatment lessens the film shrinkage. The films and laminates can be used to make a variety of finished articles that can be used to provide protection from hazardous chemical and biological agents.Type: ApplicationFiled: June 9, 2008Publication date: December 10, 2009Applicant: E.I. duPont de Nemours and CompanyInventor: Edward George Howard, JR.
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Patent number: 7619076Abstract: The present invention relates to synthetic compounds that are active on plants, especially as legume nodulation factors, and also as plant growth stimulators, and to methods for preparing such compounds, which are of formula (I):Type: GrantFiled: December 22, 2004Date of Patent: November 17, 2009Assignees: Bayer Cropscience S.A., Institut National de la Recherche Agronomique, Centre National de la Recherche ScientifiqueInventors: Jean-Marie Beau, Jean Denarie, Alfred Greiner, Nathalie Grenouillat, Fabienne Maillet, Boris Vauzeilles
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Publication number: 20090281058Abstract: The present invention relates to compositions comprising biologically active chitinous oligomers and their endotoxin purified and partially deacetylated chitin polymer precursors, and their use in pharmaceutical compositions, biomaterial compositions, medical devices, and processes to produce the said oligomers. More specifically the present invention relates to novel compositions and processes to produce such compositions. The compositions include therapeutic hetero polymer and hetero oligomer compositions comprising specific sequences of N-acetyl glucosamine and glucosamine, developed to optimize chemical and structural features which are important for the therapeutic activity of these compositions. In addition, the present invention provides methods to use degree of deacetylation of a partially deacetylated chitin polymer in order to modulate physical and biological parameters in a calcium phosphate composite for bone implant applications.Type: ApplicationFiled: June 14, 2006Publication date: November 12, 2009Applicant: GENIS EHFInventors: Johannes Gislason, Jon M. Einarsson, Ng Chuen How, Sven Bahrke
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Patent number: 7595061Abstract: A method for controlling the growth of destructive insects and microorganisms in ground soil, includes the step of adding chitin to ground soil for inducing bacteria in the ground soil to synthesize chitinase for controlling the spread of destructive insects and microorganisms therein. The chitin may be added to the ground soil by distributing it on the upper surface of the soil or, preferably, by incorporating into the soil. In a preferred embodiment, the step of deacetylating the carbohydrate chains of the chitin for is carried out before adding to the ground soil for increasing the aqueous solubility of the chitin by producing smaller polymeric units or by increasing the availability of polar hydroxyl groups on glucosyl moieties thereof. Various bacterial cultures may also be added to the chitin prior to its distribution on, or incorporation in, the ground soil.Type: GrantFiled: December 13, 2004Date of Patent: September 29, 2009Inventor: David Abecassis
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Publication number: 20090203642Abstract: The invention relates to a novel method for production of nanofibrillar chitin, sustainable from an industrial manufacturing standpoint and suitable for producing chitin nanofibrils having improved properties and free from less crystalline components. The invention also relates to novel chitin nanofibrils obtained with said method and characterized by an increased dispersibility in aqueous media. The invention further relates to uses of nanofibrils in pastes and aqueous gels useful for topical on-skin application, to the manufacturing of materials of biomedical interest, as well as to the deposition of chitin nanofibrils on coating surfaces or the incorporation of the same inside of items like, e.g., fibers and fabrics of any Origin, natural as well as synthetic or mixed ones.Type: ApplicationFiled: November 23, 2006Publication date: August 13, 2009Applicant: MAVI SUD S.r.l.Inventors: Pierfrancesco Morganti, Corrado Muzzarelli
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Publication number: 20090197789Abstract: A process for making modified N-acetylated chitosan comprising the steps of: a) forming an aqueous solution of chitosan in aqueous acid; b) mixing the resulting solution of step a) with an acetylating agent in a chitosan:acetylating agent sub-stoichiometric amount; and c) allowing the chitosan and acetylating agent to react for a length of time sufficient for substantial completion of the acetylation reaction.Type: ApplicationFiled: January 22, 2009Publication date: August 6, 2009Inventors: Anju Deepali Massey Brooker, Alan Thomas Brooker, Katherine Helen Combs, Larry Eugene Miller, Stephen Godfrey, Philip Robert Mallender
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Patent number: 7556946Abstract: In a first aspect, the present invention relates to a method for isolating cell wall derivatives from fungal or yeast biomass. According to this method, chitin polymers or chitin-glucan copolymers can be obtained. In another aspect, the invention relates to a method for preparing chitosan from chitin. The invention further relates to chitin polymers, chitin-glucan polymers and chitosan polymers obtainable by the methods according to the invention. Moreover, the invention relates to the use of chitin polymers, chitin-glucan copolymers or chitosan polymers obtainable by the method according to the present invention in medical, pharmaceutical, agricultural, nutraceutical, food, textile, cosmetic, industrial and/or environmental applications.Type: GrantFiled: February 12, 2003Date of Patent: July 7, 2009Assignee: Kitozyme S.A.Inventors: Marie-France Versali, Fabienne Clerisse, Jean-Michel Bruyere, Sandrine Gautier
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Patent number: 7544785Abstract: Disclosed is a process for the deacetylation of chitin and a process for the treatment of chitinaceous materials to obtain chitin which processes are conducted in a non-saponifiable, non-aqueous, water insoluble liquid having a flash point greater than about 100° C., preferably a non-aromatic hydrocarbon. The process for the deacetylation of chitin comprises suspending chitin in the hydrocarbon liquid, preferably from about 0.02 g/cc to about 0.2 g/cc, mixing therewith an alkali metal hydroxide solution, and heating the suspension at a temperature at least about 70° C. for a period of time sufficient to obtain the desired degree of deacetylation. The concentration of alkali metal hydroxide in the alkali metal hydroxide solution is at least 30% by weight, preferably at least 40% by weight, and most preferably at least 50% by weight, and the quantity of alkali metal hydroxide is sufficient to provide an alkali metal hydroxide to chitin weight ratio from about (0.35)(AMHMW)/40 to about (2.Type: GrantFiled: May 24, 2004Date of Patent: June 9, 2009Assignee: Venture Chemicals, Inc.Inventors: Jack C. Cowan, Andre′ N. Blanchard, Catherine G. Benoit, Tammy L. Rodrigue
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Publication number: 20090137526Abstract: The present disclosure relates to methods for purifying chitin or chitosan, particularly for obtaining medical grade materials suitable for use in biocompatible devices,formulations, or other materials. Chitosan separation and purification methods are taught for obtaining high purity and fractionated bio-compatible medical grade materials. Chemistries and solvent systems are taught for the use in counter current chromatography, liquid/liquid or other microfluidic separation systems.Type: ApplicationFiled: November 25, 2007Publication date: May 28, 2009Inventors: Carole Jubert, John Enrique Mata, Scott Bradley Gustafson, John Stephen Dunfield
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Publication number: 20090118480Abstract: The present invention relates to novel quaternized polymers, especially of chitin/chitosan type, and to carbohydrate polymers carrying quaternized ammonium groups, especially piperazinium groups. Such polymers are characterized i.a. by improved solubility characteristics.Type: ApplicationFiled: August 31, 2006Publication date: May 7, 2009Applicant: FENNOPHARMA OYInventors: Jukka Holappa, Tomi Jarvinen, Tapio Nevalainen, Jouko Savolainen, Rustam Safin
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Publication number: 20090117078Abstract: Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) die oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound.Type: ApplicationFiled: October 2, 2008Publication date: May 7, 2009Applicant: University of Utah Research FoundationInventors: Glenn D. Prestwich, Xiao Zheng Shu, Yi Luo, Kelly R. Kirker, Yanchun Liu
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Publication number: 20090110719Abstract: A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed.Type: ApplicationFiled: June 6, 2005Publication date: April 30, 2009Inventors: Krishnendu Roy, Sudhir Pai Kasturi