Viscosity Or Degree Of Polymerization Changed (e.g., Degrading, Cross Linking, Etc.) Patents (Class 536/41)
  • Patent number: 9395164
    Abstract: Methods of preparing propellant compositions for power loads and firearms that include providing pre-shaped particle sized starting material, shaped consistent with a desired final propellant product shape, and thereafter nitrating and stabilizing the pre-shaped starting material using boiling stabilization processes. The resulting nitrated propellants of the methods reliably exhibit complete stabilization, high nitrogen substitution, high shelf life and acceptable ballistic performance.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: July 19, 2016
    Assignee: Orbital ATK, Inc.
    Inventors: William J. Worrell, Benjamin R. Vaughan, Jeffrey D. Archambault, Milca Fils-Aime
  • Patent number: 8545954
    Abstract: The present invention relates to a barrier layer and a packaging laminate comprising a barrier layer and a method to produce a barrier layer. The barrier layer is manufactured of a cellulose-based hydrolysate. The barrier layer comprises lignin and oligo- or poly-saccharides, where the lignin and oligo- or polysaccharides are at least partly covalently bonded to each other in a matrix, and at least one co-component. The co-component is bonded to the lignin and oligo- or polysaccharides by means of primary and/or secondary bonds. In addition, the invention relates to a package made of the packaging laminate.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: October 1, 2013
    Assignee: Tetra Laval Holdings & Finance SA
    Inventors: Ann-Christine Albertsson, Ulrica Edlund
  • Patent number: 6979734
    Abstract: The present invention relates to rubber latex comprising an amount of starch, which rubber latex has a reduced allergen activity as compared to the same rubber latex without starch. In addition, the invention relates to the use of modified starch as donning powder for surgical gloves, wherein the used starch is a granular, low crystalline, preferably a non-crystalline starch.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: December 27, 2005
    Assignee: Budev Medical B.V.
    Inventors: Max Gregor Paping, Johannes Jeekel
  • Patent number: 6911434
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ cyclic AGPs for selectively stimulating immune responses in animals and plants.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: June 28, 2005
    Assignee: Corixa Corporation
    Inventors: Jory R. Baldridge, David A. Johnson, Christopher W. Cluff
  • Publication number: 20040137250
    Abstract: The present invention relates to water soluble radiation activatable polymer resin formulations which are suitable to modify the absorption properties of fibrous materials and the polymer obtained by such radiation activatable polymer resins and the method of preparing such polymer. Fibrous materials made with radiation activatable resin formulations according to this invention are especially suitable for use in disposable absorbent articles.
    Type: Application
    Filed: November 19, 2003
    Publication date: July 15, 2004
    Inventors: Thomas Daniel, Rainer Dyllick-Brenzinger, Ralf Fink, Karl-Heinz Schumacher, Oliver Koch
  • Patent number: 6703444
    Abstract: The present invention relates to a process for the production of hyaluronic acid (HA) derivatives. In particular, the process relates to multiple cross-linked hyaluronic acid derivatives, to navel cross-linked derivatives so obtained, and to products containing them and their uses in cosmetic, medical and pharmaceutical applications.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: March 9, 2004
    Assignee: A-Life Limited
    Inventors: Xiaobin Zhao, Catherine Alexander, Jane Fraser
  • Patent number: 6589964
    Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: July 8, 2003
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Jian-Qiang Fan, Satoshi Ishii
  • Patent number: 6380381
    Abstract: The present invention provides low-substituted hydroxypropyl cellulose exhibiting good granulation characteristics and tablet properties. Specifically, there is provided low-substituted hydroxypropyl cellulose having a hydroxypropoxyl content in the range of 5.0 to 16.0% by weight and an apparent average degree of polymerization in the range of 350 to 700.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: April 30, 2002
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventor: Sakae Obara
  • Patent number: 6166188
    Abstract: Nucleosides and oligonucleosides functionalized to include carbamate functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the carbamate group.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: December 26, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan
  • Patent number: 6162795
    Abstract: The present invention describes isolated Fagopyritol A1, isolated Fagopyritol A2, and isolated Fagopyritol B3. Compositions which include two or more of Fagopyritol A1, Fagopyritol A2, Fagopyritol B1, Fagopyritol B2, Fagopyritol B3, and D-chiro-inositol, at least one of which is an isolated Fagopyritol A1, isolated Fagopyritol A2, or isolated Fagopyritol B3, are also disclosed. Methods for preparing substantially pure Fagopyritol A1, Fagopyritol A2, Fagopyritol B1, Fagopyritol B2, Fagopyritol B3, or mixtures thereof from buckwheat are also described. The fagopyritols can be used to prepare pharmaceutical compositions, the administration of which can be used to treat diabetes.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: December 19, 2000
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Ralph L. Obendorf, Marcin Horbowicz
  • Patent number: 6162932
    Abstract: The present invention is directed to chiral intermediates in a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A).
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: December 19, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert John Mills, Conrad John Kowalski, Li-Jeng Ping, Kerry Joseph Gombatz
  • Patent number: 6156885
    Abstract: The process for the synthesis of an alkylpolyglucoside having the formula (I):H--(G).sub.n --O--R-- (I)whereinR is linear or branched, saturated or unsaturated C.sub.8 -C.sub.20 alkyl;G is a radical resulting from removal of a molecule of water from a monosaccharide; andn is an integer from 1 to 5;the process entailing reacting an alcohol with a monosaccharide or a compound capable of generating a monosaccharide in in situ, wherein the reaction is carried out in the presence of a catalyst consisting of one or more sterically hindered polyalkylarylsulfonic acids.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: December 5, 2000
    Assignee: Condea Augusta S.p.A.
    Inventors: Maria Luisa Meroni, Tullio Pellizzon
  • Patent number: 6156543
    Abstract: Process for preparing surfactant, which comprises contacting cane trash, maize by-products, sorghum by-products, barley by-products, rice by-products, fruits, chicory pulp, tubers or cynara for at least 5 seconds with a hydrolysing agent selected from an aqueous acid solution at between 20 and 150.degree. C. and an enzymatic hydrolysing composition of a plant material at between 20 and 90.degree. C. to obtain a sugar syrup, freeing the sugar syrup from any solid residues and contacting the residue-free sugar syrup with a C.sub.4-22 -alcohol at a temperature of between 20 and 150.degree. C., preferably between 30 and 110.degree. C., until a solution of surfactant glycosides is obtained, and separating the surfactant glycosides from this solution.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: December 5, 2000
    Assignee: Agro Industrie Recherches et Developpements (A.R.D.)
    Inventors: Jean-Noel Bertho, Philippe Mathaly, Veronique Dubois, Regis de Baynast de Septfontaines
  • Patent number: 6153736
    Abstract: This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.
    Type: Grant
    Filed: September 26, 1996
    Date of Patent: November 28, 2000
    Assignee: The Liposome Company, Inc.
    Inventors: Robert Bittman, Ravi K. Erukulla, Andrew C. Peters, Eric G. Mayhew
  • Patent number: 6150539
    Abstract: Compounds useful in immunosuppressive and anti-inflammatory treatment are described. The compounds are hydrolyzable triptolide analogs with improved water solubility and generally lower toxicity than the parent compound.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: November 21, 2000
    Assignee: Pharmagenesis, Inc.
    Inventor: John H. Musser
  • Patent number: 6143748
    Abstract: The present invention is concerned with a process for the preparation of antiviral 1,3-oxathiolane nucleosides comprising an intramolecular glycosylation reaction to produce exclusively the .beta.-diastereomer, and intermediates useful in the process.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: November 7, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: Mirna C. Samano, Vicente Samano, Michael David Goodyear
  • Patent number: 6143730
    Abstract: Sulfated oligosaccharides, wherein the oligosaccharide has the general formula I:R.sub.1 --(R.sub.x).sub.n --R.sub.2 (I)wherein R.sub.1 and R.sub.2 and each R.sub.x represents a monosaccharide unit, all of which may be the same or different, adjacent monosaccharide units being linked by 1.fwdarw.2, 1.fwdarw.3, 1.fwdarw.4 and/or 1.fwdarw.6 glycosidic bonds and n is an integer of from 1 to 6, and use thereof as anti-angiogenic, anti-metastatic and/or anti-inflammatory agents.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: November 7, 2000
    Assignee: The Australian National University
    Inventors: Christopher Richard Parish, William Butler Cowden
  • Patent number: 6140480
    Abstract: The present invention provides fluorescent nucleosides carrying polycyclic aromatic hydrocarbons such as anthracene, phenanthrene, pyrene stilbene, tetracene or pentacene. The subject nucleosides may be synthesized using a C-glycosidic bond formation method employing organocadium or organozinc derivatives of the aromatic compounds and coupling with a 1-.alpha.-chlororibose or deoxyribose synthon. The .alpha.-anomers of the coupling reaction may be epimerized to the .beta.-anomers by acid-catalyzed equilibration. The fluorescent nucleosides act as DNA or RNA base analogs and can be incorporated into nucleic acids. Resultant fluorescently tagged nucleic acids are useful as probes for target nucleic acids in tissues, solutions or immobilized on membranes.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: October 31, 2000
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Eric T. Kool
  • Patent number: 6136790
    Abstract: The invention relates to carbohydrate mimetics, which inhibit the binding of selectin to carbohydrate ligands, of the formula I ##STR1## excluding the compounds sialyl-Lewis-X and -A and their derivatives which, instead of an N-acetyl group, carry the substituents N.sub.3, NH.sub.2 or OH or which, instead of fucose, carry glycerol,and pharmaceutical compositions and diagnostic agents containing these derivatives, and methods for using these pharmaceutical compositions and diagnostic agents.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: October 24, 2000
    Assignee: Glycorex AB
    Inventors: Alexander Toepfer, Gerhard Kretzschmar, Eckart Bartnik, Dirk Seiffge
  • Patent number: 6133239
    Abstract: An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: October 17, 2000
    Assignees: The Biomembrane Institute, Seikagaku Corporation
    Inventors: Kazuko Handa, Mary Ellen K. Salyan, Mark R. Stroud, Sen-itiroh Hakomori
  • Patent number: 6133240
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a fucose or mannose residue, have therapeutic utility via inhibition of selectins, and thus of cell adhesion.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: October 17, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventors: Richard John Kenneth Taylor, Paul Vincent Murphy, John Gary Montana, David Thomas Manallack
  • Patent number: 6124443
    Abstract: Epimer-free sugar alcohols can be prepared from the corresponding sugars by catalytic hydrogenation with hydrogen in aqueous solution, the hydrogenation being carried out continuously at a hydrogen pressure of 100 to 400 bar and a reaction temperature of 20 to 70.degree. C. on support-free shaped bodies which are arranged in a fixed bed and are made of pressed powders of metals or alloys of the elements of the iron subgroup of subgroup VIII of the Periodic Table of the Elements together with elements of subgroup IV and/or V. The shaped bodies have a compressive strength of 20 to 220 N and an internal surface area of 10 to 100 m.sup.2 /g.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: September 26, 2000
    Assignee: Bayer Aktiengesellschaft
    Inventor: Gerhard Darsow
  • Patent number: 6124442
    Abstract: The process includes obtaining a liquid extract from a fresh plant source material and mixing the extract with a solution saturated with at least one element having an oxidation number of one or two or combinations thereof. The resulting mixture provides for a solid precipitate material and a liquid portion containing the triterpene glycosides of which is then passed through a macroporous resin. The resin is then washed with an alcohol to obtain a solution thereof containing the triterpene glycosides. The solution is condensed to provide a purified liquid triterpene glycoside solution and then a drying step is performed to obtain a dry composition containing the triterpene glycosides.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: September 26, 2000
    Inventors: James H. Zhou, Weiping He
  • Patent number: 6121437
    Abstract: Novel phosphorus protecting groups, intermediates thereof, and synthetic processes for making the same are disclosed. Oligomeric compounds are prepared through the protection of one or more internucleosidic phosphorus functionalities, preferably followed by oxidation and cleavage of the protecting groups to provide oligonucleotides.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: September 19, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Andrei P. Guzaev, Muthiah Manoharan
  • Patent number: 6121430
    Abstract: New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active properties.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: September 19, 2000
    Assignee: University of Iowa Research Foundation
    Inventors: Robert J. Linhardt, Helene G. Bazin
  • Patent number: 6121431
    Type: Grant
    Filed: June 17, 1999
    Date of Patent: September 19, 2000
    Assignee: Medivir AB
    Inventors: Bjorn Olof Classon, Bengt Bertil Samuelsson, Ingemar Sven-Anders Kvarnstrom, Lars Goran Svansson, Stefan Carl Tore Svensson
  • Patent number: 6117845
    Abstract: Disclosed are acid-stable compounds of Formula I: ##STR1## as well as pharmaceutical compositions containing the compounds as active ingredients, and methods to treat cancers in mammal, including humans, by administering one or more of the compounds to a subject in need thereof. The compounds are resistant to acid hydrolysis.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: September 12, 2000
    Assignee: Ohio State University Research Foundation
    Inventors: Margaret Clagett-Dame, Robert W. Curley, Jr., Kevin L. Weiss, Linda A. Tephly, Vishal Sikri
  • Patent number: 6103883
    Abstract: Glycolipid mimics which include a rigid hydrophobic moiety are disclosed. Methods of using the glycolipid mimics are also disclosed.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: August 15, 2000
    Assignee: HSC Research and Development Limited Partnership
    Inventors: Clifford A. Lingwood, Murugesapillai Mylvaganam
  • Patent number: 6093805
    Abstract: Novel glycosides, especially steroidal and non-steroidal glycosides are provided. The steroidal and non-steroidal glycosides preferably are prepared from aglycons which possess valuable properties such as pharmacological properties. The glycosides are prepared from useful aglycons and possess useful properties which are the same as those of their respective unglycosylated aglycons. The glycosides are provided in acylated and deacylated form. The acylated glycosides after hydrolysis of the acyl groups possess enhanced water solubility properties, as illustrated in the case where the aglycon is acetominophen.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: July 25, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Brian K. Shull, Roeland J. Tuinman, Todd A. Houston, R. Erich Klemke, Masato Koreeda
  • Patent number: 6090932
    Abstract: A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: July 18, 2000
    Assignee: Proligo LLC
    Inventors: Danny P. McGee, Wolfgang A. Pieken, David P. Sebesta, Yansheng Zhai
  • Patent number: 6087345
    Abstract: A material inhibiting lipid peroxide-increase containing fructooligosaccharides is described which can conveniently provide at a low cost a food or drink product which exerts an excellent effect of inhibiting an increase in lipid peroxides without largely changing the daily dietary contents. The intake of the material inhibiting lipid peroxide-increase of the present invention can provide an excellent means for preventing various diseases (cancer, arterial sclerosis, etc.) caused by the formation of lipid peroxides, retarding aging, etc. Moreover, use of the material inhibiting lipid peroxide-increase of the present invention makes it possible to conveniently provide foods and drinks having excellent effects of inhibiting an increase in lipid peroxides at a low cost.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: July 11, 2000
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Atsutane Ohta, Masako Otsuki, Toshio Takizawa, Takashi Adachi
  • Patent number: 6087339
    Abstract: Disclosed are novel saccharide derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: July 11, 2000
    Assignee: Synsorb Biotech, Inc.
    Inventor: Ole Hindsgaul
  • Patent number: 6086789
    Abstract: A pyruvate compound suitable for cosmetically or dermatologically administering to the skin and for use in treating diabetic ketosis or other medical treatments. The compound includes a pyruvate selected from the group of pyruvate thioester, dihydroxyacetonepyruvate, and an ester of pyruvate and a sugar or a polyol.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: July 11, 2000
    Assignee: Case Western Reserve University
    Inventors: Henri Brunengraber, Catherine Bomont, France David, Peter T. Hallowell, Kevin D. Cooper, Takhar Kasoumov
  • Patent number: 6083512
    Abstract: Novel multicomponent clostridial vaccine formulations using readily dispersible, non-depot adjuvants, such as saponin, are disclosed. The vaccines can be administered to cattle intramusculary or subcutaneously without the severe persistent local reactions, such as granulomas, abscesses, and scarring, normally seen with other multicomponent clostridial vaccines.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: July 4, 2000
    Inventor: David S. Roberts
  • Patent number: 6080725
    Abstract: The present invention is directed to vaccines comprising (1) one or more bacterial, viral or tumor-associated antigens; and (2) one or more saponin-lipophile conjugate in which a lipophilic moiety such as a lipid, fatty acid, polyethylene glycol or terpene is covalently attached to a non-acylated or desacylated triterpene saponin via a carboxyl group present on the 3-O-glucuronic acid of the triterpene saponin. The attachment of a lipophile moiety to the 3-O-glucuronic acid of a saponin such as Quillaja desacylsaponin, lucyoside P, or saponin from Gypsophila, Saponaria and Acanthophyllum enhances their adjuvant effects on humoral and cell mediated immunity. Additionally, the attachment of a lipophile moiety to the 3-O-glucuronic acid residue of non- or des-acylsaponin yields a saponin analog that is easier to purify, less toxic, chemically more stable, and possesses equal or better adjuvant properties than the original saponin.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: June 27, 2000
    Assignee: Galenica Pharmaceuticals, Inc.
    Inventor: Dante J. Marciani
  • Patent number: 6077945
    Abstract: A novel process for making an alkylpolyglycoside comprises reacting a monosaccharide with an alcohol in the presence of a binary sulfate catalyst under heat. The particular binary sulfate catalyst is a mixture of H.sub.2 SO.sub.4 and inorganic base at a normal ratio of about 0.7:1 to 1.1:1 of H.sub.2 SO.sub.4 to inorganic base. Also the alkylpolyglycoside product from the reaction mixture can be isolated so that the alkylpolyglycoside process contains less than 5 weight percent free alcohol, and further separated into a white, free flowing powder of high DP (degree of polymerization) alkylpolyglycoside and a low DP alkylpolyglycoside paste.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: June 20, 2000
    Assignee: Eastman Chemical Company
    Inventors: Charles Michael Buchanan, Matthew Davie Wood
  • Patent number: 6077944
    Abstract: The invention relates to novel secomacrolides from the class of erythromycin A, potential intermediates for preparation of novel macrolide antibiotics general formula ##STR1## and its pharmaceuticaly acceptable addition salts with inorganic or organic acids, wherein R.sub.1 represents hydrogen, C.sub.1 -C.sub.4 alkanoyl group, arylcarbonyl group and together with R.sub.2 and carbon atoms to which they are bound, cyclic carbonyl or thiocarbonyl group, R.sub.2 represents hydrogen or together with R.sub.1 and carbon atoms to which they are bound, cyclic carbonyl or thiocarbonyl group, R.sub.3 represents hydrogen, C.sub.1 -C.sub.4 alkanoyl or arylcarbonyl group,Z is hydrogen or L-cladinosyl group represented by formula (i) ##STR2## wherein R.sub.4 represents hydrogen or C.sub.1 -C.sub.4 alkanoyl group, W is hydrogen or D-desosaminyl group represented by formula (ii) ##STR3## wherein R.sub.5 represents hydrogen or C.sub.1 -C.sub.4 alkanoyl or arylcarbonyl group,X and Y together represent a lactone, or X is CH.sub.
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: June 20, 2000
    Assignee: Pliva Farmaceutska, Kemijska, Prehrambena i Kozmeticka Industrija, Dionicko Drustvo
    Inventors: Gorjana Lazarevski, Gabrijela Kobrehel, Amalija Narandja, Zrinka Banic-Tomisic
  • Patent number: 6075135
    Abstract: 7-O-(4-Amino-2,4,6-trideoxy-2-fluoro-.alpha.-L-mannopyranosyl)-daunomycinon e or -adriamycinone is now synthesized as a daunomycinone or adriamycinone derivative having the general formula ##STR1## wherein R is a hydrogen atom or hydroxyl group. These novel compounds according to this invention exhibit excellent antitumor activities and have a high solubility in water, and hence they are useful as an antitumor agent.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: June 13, 2000
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Tomio Takeuchi, Sumio Umezawa, Tsutomu Tsuchiya, Yasushi Takagi
  • Patent number: 6063769
    Abstract: Disclosed are novel 1-thiogalactose derivatives which inhibit binding of heat labile toxin (LT) and/or chlorea toxin (CT) to cell surface receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent microorganisms (e.g., bacteria, virus, fungi, and the like) such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli to cell surface receptors.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: May 16, 2000
    Assignee: Synsorb Biotech, Inc.
    Inventor: Ole Hindsgaul
  • Patent number: 6060287
    Abstract: The present invention is directed to methods for preparing biosurfactants for use in stabilizing emulsions of high viscosity hydrocarbons such as high viscosity crude oil wherein the biosurfactant is a metabolite of Pseudomonas Aeruginosa (USB-CS1). The resulting biosurfactant can be used to produce stabilized emulsions having a viscosity of below about 500 centipoise and, more preferably, below about 100 centipoise at ambient temperatures.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: May 9, 2000
    Assignee: Universidad Simon Bolivar
    Inventors: Carlos Ali Rocha, Dosinda Gonzalez, Maria Lourdes Iturralde, Ulises Leonardo Lacoa, Fernando Antonio Morales
  • Patent number: 6057431
    Abstract: The present invention provides a compound of general formula (I): ##STR1## wherein X represents group (II) or (III): ##STR2## wherein Y represents a leaving group and Z represents an oligonucleotide. The compound can specifically transfer oligonucleotides to cells which specifically recognize a specified saccharide construction. Accordingly, the compound can be used as an antiviral agent or an antitumor agent.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: May 2, 2000
    Assignee: Drug Delivery System Institute, Ltd.
    Inventors: Hiroshi Ishihara, Takayuki Kawaguchi, Masahiro Ikeda, Kazutaka Nakamoto, Atsushi Sasaki
  • Patent number: 6051615
    Abstract: A process for reducing foam in an alkyl polyglycoside-containing cleaning composition by adding a defoaming-effective amount of an alkyl polyglycoside having the general formula I:R.sub.1 O(Z).sub.a Iwherein R.sub.1 is a monovalent organic radical having from 16 to 18 carbon atoms; Z is a glucose residue having 5 or 6 carbon atoms; a is a number having a value of from 1 to about 6, to a cleaning composition containing an alkyl polyglycoside having the general formula II:R.sub.2 O(Z).sub.a IIwherein R.sub.2 is a monovalent organic radical having from 8 to 16 carbon atoms; Z is a glucose residue having 5 or 6 carbon atoms; a is a number having a value of from 1 to about 6.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: April 18, 2000
    Assignee: Henkel Corporation
    Inventors: Stephen F. Gross, John Frederick Hessel
  • Patent number: 6048712
    Abstract: The present process for producing a high .alpha.-monoglucosyl hesperidin content product is characterized in that it comprises the steps of contacting glucoamylase and .alpha.-L-rhamnosidase simultaneously or randomly with a solution containing .alpha.-glucosyl hesperidin and hesperidin to obtain a mixture; crystallizing and separating .alpha.-monoglucosyl hesperidin in and from the mixture; and collecting the resulting .alpha.-monoglucsyl hesperidin. From solutions containing .alpha.-glucosyl hesperidin and hesperidin, the present invention facilitates the production of a high .alpha.-monoglucosyl hesperidin content product which does not substantially contain hesperidin, .beta.-monoglucosyl hesperetin, and hesperetin, and has an extremely-superior water-solubility.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: April 11, 2000
    Assignees: Kabushiki Kaisha Hayashibara, Seibutsu Kagaku Kenkyujo
    Inventors: Toshio Miyake, Takashi Yumoto
  • Patent number: 6043350
    Abstract: The bonding agent composition comprises tannin of pine bark and/or pecan nut, paraformaldehyde and an ammonium salt of a weak acid. It serves inter alia as bonding agent for particle board with high transverse tensile strength, good water resistance and low formaldehyde emission.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: March 28, 2000
    Assignee: Bakelite AG
    Inventors: Willi Roll, Antonio Pizzi, Peter Stracke
  • Patent number: 6040433
    Abstract: Hexose derivatives are described which facilitate control over the stereochemistry of the glycosyl bond formed in the course of a solid phase glycosylation reaction. Methods for their use are also described.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: March 21, 2000
    Assignee: The Trustees of Princeton University
    Inventors: Daniel E. Kahne, Lin Yan
  • Patent number: 6036817
    Abstract: The efficiency by which pulp cooking liquor components penetrate the wood and enable lignin and resins to be removed from the cellulosic materials is increased by contacting wood chips and the like with a liquid mixture comprised of white liquor containing at least one surfactant selected from the group consisting of a polymethylalkylsiloxane; a co- and terpolymer of silicone and a polyhydric alcohol; an alkoxylated aryl phosphate; an alkoxylated branched alkyl phosphate; an alkoxylated branched alcohol; an alkyl polyglycoside, an alkoxylated alkyl polyglycoside; a mixture of alkali metal salts of alkyl aromatic sulfate, a sulfosuccinate and a silicone; and combinations thereof; for a residence time effective to extract resinous components without substantial degradation of cellulose and thereafter heating at least a portion of the resulting mixture and wood chips.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: March 14, 2000
    Assignee: Henkel Corporation
    Inventors: Marie-Esther Saint Victor, David I. Devore, Barbara Balos Bowker, John J. Palmer, Vincent T. Stine
  • Patent number: 6030628
    Abstract: Cosmetic or pharmaceutical preparations, characterized by an effective content of pharmaceutically and/or cosmetically acceptable glycoglycerolipids.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: February 29, 2000
    Assignee: Beiersdorf AG
    Inventors: Gunther Schneider, Oliver Scheel, Joachim Thiem
  • Patent number: 6030815
    Abstract: The present invention provides improved methods for the preparation of sialyl galactosides. The methods use sialyl transferase cycle in which the reaction conditions are optimized to provide increased yields.
    Type: Grant
    Filed: April 10, 1996
    Date of Patent: February 29, 2000
    Assignee: Neose Technologies, Inc.
    Inventors: Shawn DeFrees, Robert J. Bayer, Murray Ratcliffe
  • Patent number: 6027732
    Abstract: Lipid-containing particles such as iscoms, iscom-matrix or vesicles such as micelles or liposomes that comprise one or more hydrophobic receptor molecules for targeting and antigenic substances, which receptor molecules have been integrated in the particle and are chosen from lipid-containing receptors or receptors that are hydrophobic, which receptor molecules bind to the antigenic substances.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: February 22, 2000
    Inventors: Bror Morein, Karin Lovgren Bengtsson, Jill Ekstrom
  • Patent number: 6025482
    Abstract: Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve reductive coupling of 3'- and 4'- substituted or 4'- and 3'-substituted nucleosidic synthons.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: February 15, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Yogesh S. Sanghvi