Flavon Sugar Compounds Patents (Class 536/8)
  • Patent number: 9265703
    Abstract: Oral care compositions and methods are described in which the composition includes a chalcone color change component, which may be phenyl-3-methoxy-4-hydroxystyryl ketone. The color change component is induced to change colors by addition of saliva and/or by a change in pH of the composition. The composition and methods provide benefits including providing visual cues to the user.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: February 23, 2016
    Assignee: COLGATE-PALMOLIVE COMPANY
    Inventors: Lyndsay Schaeffer-Korbylo, Gregory Szewczyk, Laurence Du-Thumm
  • Patent number: 9040673
    Abstract: A composition comprising an SL0101 [kaempferol 3-O-(3?,4?-di-O-acetyl-?-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: May 26, 2015
    Assignee: University of Virginia Patent Foundation
    Inventors: Sidney M. Hecht, Deborah A. Lannigan-Macara, Jeffrey Allan Smith, George A. O'Doherty, Michael Kenneth Hilinski
  • Patent number: 9034834
    Abstract: The disclosure provides an oral antiviral supplement composition comprising a lysine, an ascorbic compound, a flavonoid glycoside, a threonine, and a pyridoxine. The disclosure also provides a method of reducing viral replication in a cell comprising treating a virus-infected cell with a composition of the disclosure. The disclosure further provides a method for the treatment and prophylaxis of a viral infection in a patient comprising administering a composition of the disclosure.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: May 19, 2015
    Assignee: Vymedic, LLC
    Inventors: Kenneth E. Phillips, Cynthia A. Winning
  • Patent number: 8916526
    Abstract: Provided is a novel antimicrobial agent. More specifically, provided is a novel antimicrobial agent capable of effectively acting on various resistant bacteria such as VSSA, MRSA, VISA, VRE, and VRSA. A novel flavanone derivative having a six-membered monosaccharide derivative, specifically, a glucose derivative or a galactose derivative is capable of effectively acting on the bacteria. More specifically, a compound represented by the general formula (I) is capable of effectively acting on the bacteria. (In the formula: X represents a six-membered monosaccharide derivative; and Y is substituted by a hydroxyl group.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: December 23, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Kenji Sasaki, Tomofusa Tsuchiya, Abugafar Md. Lokman Hossion, Nao Ohtsuka, Yoshito Zamami, Yuji Kurosaki
  • Publication number: 20140364382
    Abstract: The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases. In addition, the present invention relates to a method for extracting narirutin from citrus peel, and a method for preparing citrus fermented milk using the same.
    Type: Application
    Filed: March 28, 2014
    Publication date: December 11, 2014
    Applicant: KOREA FOOD RESEARCH INSTITUTE
    Inventors: In Wook Choi, Yong Kon Park, Yoon Sook Kim, Hee Don Choi, Ho Young Park
  • Publication number: 20140348965
    Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
    Type: Application
    Filed: May 22, 2013
    Publication date: November 27, 2014
    Applicant: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
  • Publication number: 20140335211
    Abstract: The present invention discloses a use of neohesperidin or a neohesperidin-containing plant extract in the manufacture of a product for improving and/or promoting skin microcirculation, or for eliminating and/or alleviating diseases or conditions associated with poor skin microcirculation. The present invention also discloses a composition comprising an effective amount of neohesperidin or a neohesperidin-containing plant extract, and to a method for improving and/or promoting skin microcirculation, or eliminating and/or alleviating diseases or conditions associated with poor skin microcirculation, by using neohesperidin. The skin microcirculation of the present invention is preferably eye skin microcirculation.
    Type: Application
    Filed: November 25, 2011
    Publication date: November 13, 2014
    Applicant: NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD
    Inventors: Liu Hu, Hongying Lan
  • Publication number: 20140329279
    Abstract: Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function.
    Type: Application
    Filed: May 6, 2014
    Publication date: November 6, 2014
    Inventors: Min Wang, Patrick M. Hossler, Sean W. McDermott, Christopher Racicot, Kofi Chemfe, John Fann
  • Patent number: 8653040
    Abstract: The purpose of the present invention is to provide a means of enhancing the bodily absorption of sesamin-class compounds. By using sesamin-class compounds and quercetin glycosides in combination, the bodily absorption of the sesamin-class compounds can be enhanced.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: February 18, 2014
    Assignee: Suntory Holdings Limited
    Inventors: Namino Tomimori, Yoshiko Ono
  • Publication number: 20140033369
    Abstract: Provided is a polynucleotide encoding a protein having an activity to transfer a sugar to the hydroxy groups at the 4?- and 7-positions of a flavone.
    Type: Application
    Filed: January 11, 2012
    Publication date: January 30, 2014
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventors: Yoshikazu Tanaka, Naoko Okitsu, Keisuke Matsui
  • Patent number: 8598128
    Abstract: Fructosylated puerarin being converted from puerarin by a bioconversion method conducted in an aqueous phase or nonaqueous phase system, including monofructosyl-(2,6)-puerarin, bifructosyl-(2,6)-puerarin, trifructosyl-(2,6)-puerarin, tetrafructosyl-(2,6)-puerarin and pentafructosyl-(2,6)-puerarin. Tests have shown that the oligosaccharylated puerarin is effective to treat acute myocardial ischemia, and can markedly suppress in vitro the proliferation of human breast cancer cell strain MDA-MB-23 and human chronmyelogenors leukemia cell strain K562, and it has a low toxicity.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: December 3, 2013
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Patent number: 8597712
    Abstract: A method for removing isoflavones from a soy-based beverage is disclosed. The method includes processing a soy base by subjecting ground or milled soy beans to one or more of sonic vibration and ultrahigh pressure homogenization. The soy base is separated, using centrifugation, into a lipid phase substantially free from isoflavones and a serum phase containing isoflavones. One or more isoflavones are separated from the serum phase. The serum phase is mixed with the lipid phase.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: December 3, 2013
    Assignee: WhiteWave Services, Inc.
    Inventors: Kirby Hayes, Dennis Lane
  • Patent number: 8569249
    Abstract: Provided is a method for inhibiting the activation of macrophages in a subject, comprising administrating to the subject an effective amount of an active component selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable ester of the compound, and combinations thereof:
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: October 29, 2013
    Assignee: China Medical University
    Inventors: Wen-Chuan Lin, Jin-Bin Wu, Hui-Ya Ho, Hung-Bo Hsiao
  • Patent number: 8513395
    Abstract: The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilize a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: August 20, 2013
    Assignee: Biosynth AS
    Inventor: Einar Bakstad
  • Publication number: 20130122073
    Abstract: The invention relates to a composition, particularly in the form of liquid to be used externally as a rinsing contact lenses, containing nanocrystalline photocatalyst active in visible light, and optionally hydrogen peroxide.
    Type: Application
    Filed: April 23, 2011
    Publication date: May 16, 2013
    Applicant: UNIWERSYTET JAGIELLONSKI
    Inventors: Przemyslaw Labuz, Wojchiech Maccyk, Grazyna Stochel, Piotr Heczko, Magdalena Strus
  • Patent number: 8436155
    Abstract: A 7,2?-dehydrate puerarin represented by formula (I) and salt derivatives thereof. The compounds are prepared from puerarin by intramolecular mitsunobu reaction. They are capable of shortening arrhythmia duration and prolonging coagulation time. They can be prepared into oral formulations or injections for treatment of cardiovascular and cerebrovascular diseases including arrhythmia, coronary heart disease, angina pectoris, myocardial infarction, and cerebral infarction.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: May 7, 2013
    Assignee: Shandong University
    Inventors: Hongxiang Lou, Jian Gao, Xia Xue
  • Patent number: 8426568
    Abstract: The present invention provides compositions and methods useful for preparing and using analogs, derivatives, and modifications of kaempferols that have anti-neoplastic activity. More specifically, the compounds are analogs, derivatives, and modifications of SLO1O1. The invention further provides compounds that are inhibitors of rsk activity. The invention further provides compounds that selectively inhibit excessive rsk activity in cancers. The present invention further provides methods for treating cancer using compounds of the invention.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: April 23, 2013
    Assignee: University of Virginia Patent Foundation
    Inventors: Jeffrey A. Smith, Sidney M. Hecht, Deborah A. Lannigan-Macara, David J. Maloney
  • Patent number: 8425960
    Abstract: The present invention relates to a coloring food composition containing modified colorings of the anthocyanin family and to a process for the bathochromic modification of these colorings. This coloring composition can be used as additive or ingredient in food preparations.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: April 23, 2013
    Assignee: Diana Naturals
    Inventors: Claude Inisan, Matthieu Besnard, Cecile Bahu, Denis Megard
  • Publication number: 20130085270
    Abstract: A method for producing a polyphenol composition including a step of subjecting (A) a hardly water-soluble polyphenol and (B) one or more selected from cathechins, chlorogenic acids and methylated compounds of hardly water-soluble polyphenols to a heat treatment at from 100 to 180° C. in the presence of an aqueous medium.
    Type: Application
    Filed: June 8, 2011
    Publication date: April 4, 2013
    Applicant: KAO CORPORATION
    Inventors: Yasushi Yamada, Keigo Hanaki, Toshiteru Komatsu
  • Patent number: 8377895
    Abstract: The present invention provides a series of cyclin-dependent protein kinases (Cdks) inhibitors, Scutellaria flavonoid organic amine derivatives, synthesis and use thereof. The preparation method is as follows: taking Baicalein (or Wogonin) from Scutellaria baicalensis as lead compound, mixting it with formaldehyde solution and organic amine compounds based on the molar ratio of 1:1-1.2:1-1.2, adding methanol of duplicate weight than baicalein and reacting at 50-70° C., filtering the sediment and washing and then drying so as to get the product with a content of not less than 97% (weight). Similar to Flavopiridol and P276-00, the activity of baicalein organic amine derivatives inhibiting Cdks has an increase of 50 times compared with that of Baicalin. It can selectively induce apoptosis of the proliferative phase cancer cells, which has scarcely any influence to the normal structure, and it belongs to anticancer drugs of cell cycle inhibitor kind.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: February 19, 2013
    Inventors: Shixuan Zhang, Yongming Bao, Yuming Sun, Kangjian Li, Liang Zou, Jigang Ma, Xiaodan Sun, Haiyan Shang, Jing Li
  • Patent number: 8338624
    Abstract: Isoflavone derivatives are provided comprising a carboxyalkylene moiety linked via its alkylene chain to the aromatic ring and via its carboxy group to an aminoalkyleneamino residue, which, in turn, is covalently linked to a functional group B. The isoflavone derivatives are preferably derived from biochanin A, genistein, and daidzein, and the functional group B is preferably an amino protecting group. These isoflavone derivatives are useful for treating or preventing diseases or disorders associated with estrogen receptor functioning.
    Type: Grant
    Filed: February 20, 2008
    Date of Patent: December 25, 2012
    Assignees: Yeda Research and Development Co., Ltd., Medical Research and Infrastructure Fund of Tel-Aviv Sourasky Medical Center
    Inventors: Fortune Kohen, Dalia Somjen, Naftali Stern, Veronica Frydman, Tikva Kulik, Batya Gayer
  • Publication number: 20120245111
    Abstract: The present invention relates to food products comprising flavanones. In particular, it relates to food products comprising hesperidin having improved stability. The present invention also concerns processes for the manufacturing of food products comprising said flavanones, especially hesperidin and to the use of the food products in the manufacture of compositions for the improvement of bone and skin health. Said flavanones are subjected to heating in water to a temperature of at least 138° C.
    Type: Application
    Filed: July 22, 2010
    Publication date: September 27, 2012
    Applicant: NESTEC S.A.
    Inventor: Pascaline Hoebler
  • Publication number: 20120245112
    Abstract: A composition comprising an SL0101 [kaempferol 3-O-(3?,4?-di-O-acetyl-?-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.
    Type: Application
    Filed: August 13, 2010
    Publication date: September 27, 2012
    Inventors: Sidney M. Hecht, Deborah A. Lannigan-Macara, Jeffrey Allan Smith, George A. O'doherty, Michael Kenneth Hilinski
  • Patent number: 8252835
    Abstract: Provided herein in certain embodiments are compounds, pharmaceutical compositions and methods for modulating the functions of estrogen receptor alpha 36, for preventing and/or treating diseases related to estrogen receptor alpha 36, for preventing and/or treating respiratory diseases such as asthma, for inducing cell death and/or inhibiting cell proliferation and for preventing and/or treating diseases involving abnormal cell proliferation such as cancers.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: August 28, 2012
    Assignee: Shenogen Pharma Group Ltd.
    Inventors: Jin Li, Kun Meng
  • Patent number: 8207313
    Abstract: New and useful compounds C. roseus cultured hairy roots are provided, by Isolating flavone glycosides together with a pharmaceutically acceptable carrier. This is accomplished by immersing powdered the hairy roots in methanol to produce an extract, concentrating the extract, resuspending the extract in water, extracting the compound with organic solvent, and isolating the compound from the organic solvent.
    Type: Grant
    Filed: February 18, 2008
    Date of Patent: June 26, 2012
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, Ill-Min Chung, Ateeque Ahmad
  • Publication number: 20120087980
    Abstract: Flavonoid glycosides, such as isoquercitrin, are shown to stimulate the formation of neuritis and neuronal synapses in neurons and neuronal progenitor (stem) cells.
    Type: Application
    Filed: September 30, 2011
    Publication date: April 12, 2012
    Inventor: Marcy Zenobi-Wong
  • Patent number: 8075902
    Abstract: New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways. We unexpectedly found that surprisingly low doses of anti-hibernation compounds can substantially inhibit cancer cell growth in vitro and can successfully treat cancers, including metastatic cancer. We also unexpectedly found that antimicrobial agents and anti-HDS compounds together can increase the degree of inhibition of cancer cell growth in a synergistic fashion. We conclude that combination therapy with antimicrobial agents and anti-HDS compounds can be effective in treating human patients with cancer.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: December 13, 2011
    Inventor: Michael Powell
  • Patent number: 8008458
    Abstract: This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids including acids have between 12 and 24 carbon atoms. The phenol can be a polynuclear phenol, a polyphenol or a polyfunctional phenol having a variety of substituents. The formulation can include pharmaceutically acceptable carrier, including diluent. The formulation can be provided in an active dosage form suitable to inhibit mammalian cell growth and/or metastasis of malignant cells. The formulation can be used to induce cytotoxicity in mammalian cells particularly tumor cells or to treat and prevent cellular injury or dysfunction.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: August 30, 2011
    Assignee: Indiana University Health Inc.
    Inventors: Gary P. Zaloga, Rafat Siddiqui, William Stillwell
  • Patent number: 7998937
    Abstract: The present invention relates to a flavonoid compound having an antiviral activity, more particularly to a flavonoid compound obtained by extracting Houttuynia cordata with methanol and separating/purifying with chromatography, a method for efficient extraction and purification of the same and an antiviral composition comprising the compound as an active ingredient.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: August 16, 2011
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Dur Han Kwon, Wha Jeong Choi, Choong Hwan Lee, Jin Hee Kim, Man Bae Kim
  • Publication number: 20110195138
    Abstract: The present invention is directed to extracts of cranberries (Vaccinium macrocarpon) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-?-xylopyranoside, quercetin-3-?-glucoside, quercetin-3-?-arabinopyranoside, 3?-methoxyquercetin-3-?-xylopyranoside, quercetin-3-O-(6?-p-coumaroyl)-?-galactoside, and quercetin-3-O-(6?-benzoyl)-?-galactoside. The present invention also embodies the use of those extracts, as well as extracts comprising the cranberry flavonol compound quercetin-3-?-arabinofuranoside, for the treatment of inflammatory disorders. Pharmaceutical, food, dietary supplement, and cosmetic compositions utilizing the extracts or compounds of the present invention are also recited.
    Type: Application
    Filed: November 18, 2008
    Publication date: August 11, 2011
    Inventors: Nicholi Vorsa, Irina O. Vvedenskaya, Mou-Tuan Huang, Robert T. Rosen, Sharon L. Rosen
  • Publication number: 20110183930
    Abstract: The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-?-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.
    Type: Application
    Filed: March 21, 2011
    Publication date: July 28, 2011
    Applicant: LIBRAGEN
    Inventors: DANIEL AURIOL, Renaud Nalin, Patrick Robe, Fabrice Lefevre
  • Patent number: 7943164
    Abstract: A composition and method for treating diabetes and metabolic disorders, and for achieving weight loss in a subject comprising a combination of naturally occurring compounds is provided.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: May 17, 2011
    Inventors: Milton Joseph Ahrens, Daryl Lee Thompson
  • Patent number: 7935672
    Abstract: The invention relates to: (i) the use of osyl derivatives of genkwanin and sakuranetin having formula (I) in (a) cosmetics or dermatology and (b) therapeutics; (ii) the use of novel derivatives having formula (I) as industrial products; and (iii) the production method thereof [Formula (I)], wherein symbol [Formula (II)] represents a single or double bond, R represents H or an osyl residue, particularly with structure S1 or s2 [Formula (III)], Z represents H, an alkyl group at C1-C4, acyl at C1-C5, monosaccharide or sulphate.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: May 3, 2011
    Inventors: Michel Prost, Jacqueline Ragot, Pierre Tubery
  • Patent number: 7935673
    Abstract: It is an objective of the present invention to provide a polyphenol glycoside isolated from acerola, which has a binding mode that has not been conventionally known, and to provide the use of the same. The present invention relates to a compound represented by formula (I): and an antioxidant, a glucosidase inhibitor, a food, a cosmetic, and a skin preparation for external use, each of which comprises such compound.
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: May 3, 2011
    Assignee: Nichirei Biosciences, Inc.
    Inventors: Masakazu Kawaguchi, Kenichi Nagamine
  • Publication number: 20110028416
    Abstract: Compositions and methods for maintenance of bone health or prevention, alleviation and/or treatment of bone disorders are presented. The present invention also provides the manufacture of a nutritional product, a supplement or a medicament for promoting bone growth or for the maintenance of bone health and methods regarding same. In an embodiment, the present invention provides a composition comprising an active ingredient having an effective amount of a plant or plant extract containing at least one phytochemical having the ability to induce bone morphogenic protein expression.
    Type: Application
    Filed: February 25, 2008
    Publication date: February 3, 2011
    Applicant: NESTEC S.A.
    Inventors: Elizabeth Offord Cavin, Gary Williamson, Didier Courtois, Bernard Lemaure, Andre Touche, Grace Ing Soon, Laurent Ameye
  • Patent number: 7863248
    Abstract: A tyrosinase activity inhibitor and an ameliorant for facial blood flow that are excellent in terms of safety, and medicinal compositions, food compositions, and cosmetic preparations that contain the inhibitor and the ameliorant as active ingredients are provided. A tyrosinase activity inhibitor and an ameliorant for facial blood flow that contain anthocyan obtained by concentration or extraction of plant material, and medicinal compositions, food compositions, and cosmetic preparations that have an inhibitory action on tyrosinase activity and ameliorating action on facial blood flow are provided.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: January 4, 2011
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Hitoshi Matsumoto, Yuko Nakamura, Megumi Yamagishi, Kyoko Ito
  • Patent number: 7863428
    Abstract: This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed to yield photostable fluorescent products, and are particularly fitted for visualising enzyme-derived activities in cell-based assays.
    Type: Grant
    Filed: December 26, 2003
    Date of Patent: January 4, 2011
    Assignee: Tibotec BVBA
    Inventors: Inge Dierynck, Jan Ludwig Goeman, Koenraad Lodewijk August Van Acker, Johan Theo André Van Der Eycken
  • Publication number: 20100316748
    Abstract: The invention provides the use of an extract of a plant of the genus Elephantorrhiza and at least one compound selected from quercitin-3?-O-glucoside, trans-3-O-galloyl-3,3?,5,5?,7-pentahydroxyflavan, taxifolin-3?-O-glucoside, catechin and epicatechin in the preparation of a medicament for the treatment of benign prostatic hyperplasia (BPH). The mode of action is by a route selected from blocking the conversion of testosterone to dihydrotestosterone by inhibiting the 5?-reductase enzyme or by reducing oxidative stress or both.
    Type: Application
    Filed: April 8, 2008
    Publication date: December 16, 2010
    Inventors: Gerda Fouche, Vinesh Jaichand Maharaj, Xolani Mthembu, Louis Ackerman, Marina Van Der Merwe
  • Publication number: 20100311676
    Abstract: The purpose of the present invention is to provide a means of enhancing the bodily absorption of sesamin-class compounds. By using sesamin-class compounds and quercetin glycosides in combination, the bodily absorption of the sesamin-class compounds can be enhanced.
    Type: Application
    Filed: December 19, 2008
    Publication date: December 9, 2010
    Applicant: Suntory Holdings Limited
    Inventors: Namino Tomimori, Yoshiko Ono
  • Patent number: 7837895
    Abstract: During the investigation of the mechanism that cellular water in woody plants growing in cold districts keeps liquid state at low temperature, the inventors have studied to identify the causative substances. As the results, the present inventors identified supercooling promoting agents in woody plants. The supercooling ability of identified flavonoid glycoside and synthesized flavonoid glycoside with similar structure was tested. It was found that the supercooling promoting agent comprising these flavonoid glycosides enables to stably supercool bulk water at low temperature for long-term. The aqueous solution containing the supercooling promoting agent of the present invention is useful to store biological materials at low temperature.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: November 23, 2010
    Assignees: National University Corporation Hokkaido University, Olympus Corporation
    Inventors: Seizo Fujikawa, Jun Kasuga, Yasuyuki Hashidoko, Keita Arakawa, Yukiharu Fukushi
  • Publication number: 20100256345
    Abstract: The present invention provides a method for preparing a glycoside of a flavonoid compound, which comprises the step of treating flavonoid and a glycosyl donor with an enzymatic agent having glycosylation activity and being derived from the genus Trichoderma (preferably Trichoderma viride or Trichoderma reesei). Such a flavonoid compound includes a catechin compound or a methylated derivative thereof, and the glycosyl donor includes a carbohydrate containing a maltotriose residue (preferably maltotriose, maltotetraose, maltopentaose, maltohexaose, maltoheptaose, dextrin, ?-cyclodextrin or soluble starch). Glycosides obtained by the present invention have higher water solubility, improved taste, and increased stability. The present invention also provides novel glycosides of catechin compounds, which are obtained by the method of the present invention.
    Type: Application
    Filed: January 18, 2008
    Publication date: October 7, 2010
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventors: Misa Ochiai, Harukazu Fukami, Masahiro Nakao, Akio Noguchi
  • Publication number: 20100197619
    Abstract: The present invention provides a series of cyclin-dependent protein kinases (Cdks) inhibitors, Scutellaria flavonoid organic amine derivatives, synthesis and use thereof. The preparation method is as follows: taking Baicalein (or Wogonin) from Scutellaria baicalensis as lead compound, mixting it with formaldehyde solution and organic amine compounds based on the molar ratio of 1:1-1.2:1-1.2, adding methanol of duplicate weight than baicalein and reacting at 50-70° C., filtering the sediment and washing and then drying so as to get the product with a content of not less than 97% (weight). Similar to Flavopiridol and P276-00, the activity of baicalein organic amine derivatives inhibiting Cdks has an increase of 50 times compared with that of Baicalin. It can selectively induce apoptosis of the proliferative phase cancer cells, which has scarcely any influence to the normal structure, and it belongs to anticancer drugs of cell cycle inhibitor kind.
    Type: Application
    Filed: July 7, 2009
    Publication date: August 5, 2010
    Inventors: Shixuan Zhang, Yongming Bao, Yuming Sun, Kangjian Li, Liang Zou, Jigang Ma, Xiaodan Sun, Haiyan Shang, Jing Li
  • Patent number: 7713940
    Abstract: An isoflavone composition which contains an ?-glucosyl isoflavone and isoflavone and optionally an isoflavone aglycone, wherein the ratio of the amount of aglycone in the isoflavone and the isoflavone aglycone in total to the amount of aglycone in the ?-glucosyl isoflavone [(the amount of aglycone in ?-glucosyl isoflavone)/(the amount of aglycone in isoflavone plus the amount of isoflavone aglycone)] is at least 2.5/1; a water-soluble isoflavone composition which contains an ?-glucosyl isoflavone, isoflavone and isoflavone aglycone, wherein the ratio of the amount of isoflavone aglycone in the composition is 0.01 to 20% to the total amount of aglycone in the composition; and beverages, cosmetics, pharmaceuticals, or feeds, which contain any one of the above compositions.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: May 11, 2010
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Taketoshi Kido, Yoshihisa Iida, Takashi Yumoto, Toshi Miyake
  • Publication number: 20100093984
    Abstract: The present invention relates to a process for the preparation of tiliroside or tiliroside-containing extracts from parts of a plant selected from the Sterculiaceae family, to corresponding extracts, and to the use of the extracts or process products in cosmetics or topical applications.
    Type: Application
    Filed: December 14, 2009
    Publication date: April 15, 2010
    Inventors: Corinna WIRTH, Herwig Buchholz, Alexandre Andrade De Souza Costa
  • Publication number: 20100062492
    Abstract: Disclosed are a method for preparing icariside II represented by Formula 1, which inhibits the glycosylation of glycoprotein enzyme tyrosinase by inhibiting the enzymatic activity of alpha-glucosidase, which is an enzyme in the glycosylation of tyrosinase, as well as a skin whitening composition.
    Type: Application
    Filed: September 19, 2007
    Publication date: March 11, 2010
    Applicant: Amorepacific Corporation
    Inventors: Jun Seong Park, Hye Yoon Park, Ho Sik Rho, Soo Mi Ahn, Duck Hee Kim
  • Publication number: 20100048494
    Abstract: New and useful compounds C. roseus cultured hairy roots are provided, by Isolating flavone glycosides together with a pharmaceutically acceptable carrier This is accomplished by immersing powdered the hairy roots in methanol to produce an extract, concentrating the extract, resuspending the extract in water, extracting the compound with organic solvent, and isolating the compound from the organic solvent.
    Type: Application
    Filed: February 18, 2008
    Publication date: February 25, 2010
    Applicant: RICE UNIVERSITY
    Inventors: Ka-Yiu San, Ill-Min Chung, Ateeque Ahmad
  • Publication number: 20100029918
    Abstract: It is an objective of the present invention to provide a polyphenol glycoside isolated from acerola, which has a binding mode that has not been conventionally known, and to provide the use of the same. The present invention relates to a compound represented by formula (I): and an antioxidant, a glucosidase inhibitor, a food, a cosmetic, and a skin preparation for external use, each of which comprises such compound.
    Type: Application
    Filed: December 12, 2005
    Publication date: February 4, 2010
    Applicant: NICHIREI BIOSCIENCES INC.
    Inventors: Masakazu Kawaguchi, Kenichi Nagamine
  • Publication number: 20090302265
    Abstract: During the investigation of the mechanism that cellular water in woody plants growing in cold districts keeps liquid state at low temperature, the inventors have studied to identify the causative substances. As the results, the present inventors identified supercooling promoting agents in woody plants. The supercooling ability of identified flavonoid glycoside and synthesized flavonoid glycoside with similar structure was tested. It was found that the supercooling promoting agent comprising these flavonoid glycosides enables to stably supercool bulk water at low temperature for long-term. The aqueous solution containing the supercooling promoting agent of the present invention is useful to store biological materials at low temperature.
    Type: Application
    Filed: July 11, 2007
    Publication date: December 10, 2009
    Inventors: Seizo Fujikawa, Jun Kasuga, Yasuyuki Hashidoko, Keita Arakawa, Yukiharu Fukushi
  • Patent number: 7622450
    Abstract: The present invention relates to novel flavone C-glycoside derivatives or salts thereof, especially those showing an anti-allergic effect, and compositions containing them. Recently, cases of allergic diseases, especially pollenosis and atopic dermatitis have increased to such a degree that they have become a social problem. Flavones and their glycosides have been reported to have the effect of inhibiting histamine release from mast cells or an immunosuppressive effect and expected for application as allergy therapies. However, most flavones exhibit their effects only at high doses, so that effective compounds at lower doses are highly desired. The present invention provides novel components capable of treating allergic diseases at low doses and compositions containing them.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: November 24, 2009
    Assignee: Suntory Holdings Limited
    Inventors: Yoshiyuki Ishikura, Kuniro Tsuji, Haruo Nukaya
  • Publication number: 20090130051
    Abstract: Novel flavonoid compounds having anti-oxidant activity are described. The compounds and compositions have been shown to exhibit anti-oxidant properties and are particularly useful in the treatment of ischemia and reperfusion injuries. The invention also describes a method to chemically synthesize such flavonoid compounds and test their efficacy. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have uses in the areas of pharmaceuticals, nutraceutical, and veterinary applications.
    Type: Application
    Filed: March 10, 2006
    Publication date: May 21, 2009
    Applicants: Howard Florey Institute Of Experimental Physiology And Medicine, Neuprotect Pty Ltd
    Inventors: Bevyn Jarrott, Clive Newton May, Owen Llewellyn Woodman, Gregory James Dusting