Hetero Ring Patents (Class 544/209)
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Patent number: 6645915Abstract: The invention relates to novel substituted 1,3,5-triazines of the general formula (I) in which A represents CHR3R4 or represents C1-halogenoalkyl-substituted C3-C6-cycloalkyl, C3-C6-alkinyl or C1-C4-cyanoalkyl, where R1, R2, R3 and R4 are each as defined in the description, and to processes for their preparation, to novel intermediates, including their preparation, and to the use of the compounds of the general formula (I) as herbicides.Type: GrantFiled: July 13, 2001Date of Patent: November 11, 2003Assignees: Nihon Bayer Agrochem K. K., Bayer AktiengesellschaftInventors: Hans-Jochem Riebel, Akihiko Yanagi, Yukiyoshi Watanabe, Toshio Goto, Kristian Kather, Stefan Lehr, Katharina Voigt, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
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Patent number: 6645964Abstract: The present invention relates to cancer therapy and to novel anticancer agent having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans.Type: GrantFiled: November 28, 2000Date of Patent: November 11, 2003Assignee: Aventis Pharma S.A.Inventors: Patrick Mailliet, Jean-François Riou, Jean-Louis Mergny, Abdelazize Laoui, François Lavelle, Odile Petitgenet
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Publication number: 20030208073Abstract: The invention relates to novel substituted N-aryl nitrogen-containing heterocyclic compounds of the general formula (I) 1Type: ApplicationFiled: January 29, 2003Publication date: November 6, 2003Inventors: Karl-Heinz Linker, Kurt Findeisen, Otto Schallner, Andreas Lender, Hans-Joachim Santel, Markus Dollinger, Akihiko Yanagi, Toshio Goto
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Patent number: 6638932Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein —a1═a2—a3═a4— forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached vinyl group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxycarbonyl or substituted C1-6alkyl; each R2 independently is hydroxy, halo, optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl, C3-7cycloalkyl, C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)pR4, —NH—S(═O)pR4, —C(═O)R4, —NHC(═O)H, —C(═O)NHNH2, —NHC(═O)R4, —C(═NH)R4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-10alkyl, C2-10alkType: GrantFiled: August 2, 2001Date of Patent: October 28, 2003Assignee: Janssen Pharmaceutica N.V.Inventors: Bart De Corte, Marc René de Jonge, Jan Heeres, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici, Koen Jeanne Alfons Van Aken
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Patent number: 6638926Abstract: This invention provides novel pyrazole compounds that are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3. The compounds may be used to treat abnormal physiological function leading to diseases such as cancer, diabetes and Alzheimer's disease.Type: GrantFiled: September 14, 2001Date of Patent: October 28, 2003Assignee: Vertex Pharmaceuticals IncorporatedInventors: Robert J. Davies, Pan Li, Jean-Damien Charrier, David Bebbington
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Publication number: 20030191126Abstract: A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active ingredient: 1Type: ApplicationFiled: January 17, 2003Publication date: October 9, 2003Applicant: SUMITOMO PHARMACEUTICALS COMPANY LIMITEDInventors: Toru Kodo, Shuji Masumoto, Koji Koyama, Naoya Kinomura
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Patent number: 6630469Abstract: Amino-pyrimidine and amino-triazine derivatives having 5-HT7 antagonist activity for the treatment of sleeping disorders, depression, schizophrenia, anxiety, obsessive compulsive disorders, circadian rhythm disorders, ocular disorders and/or centrally and peripherally mediated hypertension are provided.Type: GrantFiled: April 24, 2001Date of Patent: October 7, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Poss, Ashok V. Purandare, Ronald J. Mattson, Li-Qiang Sun
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Patent number: 6630470Abstract: Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compounds.Type: GrantFiled: November 20, 2000Date of Patent: October 7, 2003Assignee: SmithKline Beecham CorporationInventors: Juan I Luengo, Kevin J Duffy
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Publication number: 20030166644Abstract: Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.Type: ApplicationFiled: December 13, 2002Publication date: September 4, 2003Inventors: Soren Ebdrup, Johannes Cornelis de Jong, Poul Jacobsen, Holger Claus Hansen, Per Vedso
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Publication number: 20030153570Abstract: The invention relates to aryl triazines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity and/or proliferation of cells such as tumor cells.Type: ApplicationFiled: October 30, 2002Publication date: August 14, 2003Applicant: Cell Therapeutics, Inc.Inventors: Rama Bhatt, Baoqing Gong, Feng Hong, Scott A. Jenkins, J. Peter Klein, Anil M. Kumar, John Tulinsky
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Publication number: 20030149041Abstract: Compounds that selectively inhibit inappropriate kinase activities and methods for their preparation are disclosed.Type: ApplicationFiled: June 28, 2002Publication date: August 7, 2003Applicant: Pharmacopeia, Inc.Inventors: Shawn David Erickson, James Inglese, Jeffrey John Letourneau, Christopher Mark Riviello
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Patent number: 6596461Abstract: A compound of formula (I) wherein n is e.g. a number from 2 to 50; R5′ and R5″ are e.g. a group of formula (II); G1, G2, G3 and G4 are e.g. C1-C4akyl; R1 is e.g. hydrogen or C1-C4alkyl; R2 is e.g. methylene; R3′ is e.g. hydrogen and R3″ is e.g. hydrogen or C1-C4alkyl; R4 is e.g. C2-C8alkylene; and X is e.g. —N(R7)R8) with R7 and R8 being independently of one another hydrogen or C1-C8alkyl, is useful for stabilizing an organic material against degradation induced by light, heat or oxidation.Type: GrantFiled: May 22, 2001Date of Patent: July 22, 2003Assignee: Ciba Specialty Chemicals CorporationInventors: Dario Lazzari, Mirko Rossi, Graziano Zagnoni, Alessandro Zedda, Valerio Borzatta, Stephen Mark Andrews
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Publication number: 20030114451Abstract: The present invention describes novel isoxazolo[1,5-a]pyrimidines of formula: 1Type: ApplicationFiled: March 27, 2002Publication date: June 19, 2003Inventor: William Eric Frietze
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Patent number: 6576631Abstract: A pyrimidinylbenzimidazole or triazinylbenzimidazole derivative represented by the general formula (I): wherein A is N or CR3, and R1, R2, R3, X, Y and n are as defined in the disclosure.Type: GrantFiled: May 8, 2001Date of Patent: June 10, 2003Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Masaru Shibata, Kiyoshi Kawai, Takechi Makihara, Norihisa Yonekura, Takehiro Kawashima, Junetsu Sakai, Norimichi Muramatsu
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Patent number: 6569856Abstract: This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.Type: GrantFiled: January 3, 2002Date of Patent: May 27, 2003Assignee: Synaptic Pharmaceutical CorporationInventors: Mohammad R. Marzabadi, Stewart A. Noble, Mahesh N. Desai
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Publication number: 20030087908Abstract: The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer and angiogenesis-related disease.Type: ApplicationFiled: April 10, 2002Publication date: May 8, 2003Inventors: Stephanie D. Geuns-Meyer, Lucian V. DiPietro, Joseph L. Kim, Vinod F. Patel
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Publication number: 20030078265Abstract: N-Heterocyclic derivatives of the formula (I): 1Type: ApplicationFiled: April 12, 2002Publication date: April 24, 2003Applicant: Berlex Laboratories, Inc.Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
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Publication number: 20030069245Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with indoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.Type: ApplicationFiled: December 19, 2001Publication date: April 10, 2003Inventors: Owen B. Wallace, Tao Wang, Kap-Sun Yeung, Bradley C. Pearce, Nicholas A. Meanwell, Zhilei Qiu, Haiquan Fang, Qiufen May Xue, Zhiwei Yin
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Publication number: 20030060452Abstract: N-Heterocyclic derivatives of the formula (I): 1Type: ApplicationFiled: April 12, 2002Publication date: March 27, 2003Applicant: Berlex Laboratories, Inc.Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
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Publication number: 20030060608Abstract: Disclosed are compositions for printing recording materials, especially textile fibre materials, paper and papery substrates and plastic films and plastic transparencies by the inkjet printing process, includingType: ApplicationFiled: September 20, 2002Publication date: March 27, 2003Inventors: Ludwig Hasemann, Reinhard Pedrazzi, Josef Geisenberger, Josef Ritter, Hans-Tobias Macholdt, Andreas Wuzik
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Publication number: 20030027794Abstract: N-Heterocyclic derivatives of the formula (I): 1Type: ApplicationFiled: April 12, 2002Publication date: February 6, 2003Applicant: Berlex Laboratories, Inc.Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
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Publication number: 20030022885Abstract: This invention describes novel pyrazole compounds of formula II: 1Type: ApplicationFiled: December 20, 2001Publication date: January 30, 2003Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Francoise Pierard
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Patent number: 6509338Abstract: The present invention describes novel pyrazolo[1,5-a]triazines of formula: wherein R3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists.Type: GrantFiled: June 14, 1999Date of Patent: January 21, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Richard Eric Olson, William Eric Frietze
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Publication number: 20030004166Abstract: This invention is directed to sorbitol dehydrogenase inhibitory compounds of formula I 1Type: ApplicationFiled: March 26, 2002Publication date: January 2, 2003Inventor: Banavara L. Mylari
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Patent number: 6492440Abstract: A product obtainable by 1) reacting a compound of the formula (&agr;) with a compound of the formula (&bgr;) in a molar ratio of 1.2:1 to 1.4:1; 2) reacting the end groups of the formula (&ggr;) being present in the product of the reaction 1) with e.g. dibutylamine in a molar ratio of 2:1.7 to 2:3; the reactions 1) and 2) being carried out in an organic solvent in the presence of an inorganic base; and 3) transferring the groups of the formula being present in the product of the reaction 2) to groups of the formula said transfer being carried out by reacting the product of the reaction 2) with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst. The products obtained are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers such as polyolefins.Type: GrantFiled: June 9, 2000Date of Patent: December 10, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli, Ivan Orban
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Publication number: 20020183323Abstract: N-Heterocyclic derivatives of the formula (I): 1Type: ApplicationFiled: April 12, 2002Publication date: December 5, 2002Applicant: Berlex Laboratories, Inc.Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
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Patent number: 6489333Abstract: This invention relates to novel heterocycles which are useful as antagonists of the &agr;v&bgr;3 integrin, the &agr;2b&bgr;3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.Type: GrantFiled: April 9, 2001Date of Patent: December 3, 2002Assignee: Bristol - Meyers Squibb Pharma CompanyInventors: William J. Pitts, Prabhakar K. Jadhav
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Publication number: 20020165203Abstract: N-Heterocyclic derivatives of the formula (I): 1Type: ApplicationFiled: April 12, 2002Publication date: November 7, 2002Applicant: Berlex Laboratories, Inc.Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
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Patent number: 6476026Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.Type: GrantFiled: March 15, 2000Date of Patent: November 5, 2002Assignee: Axys Pharmaceuticals, Inc.Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
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Patent number: 6472384Abstract: The present invention relates to ester, ether and N-alkylcarbamoyl derivatives of compound (Ia) and pharmaceutically acceptable salts thereof. These compounds exhibit excellent antibacterial activity and are useful for the treatment or prevention of bacterial infections. (wherein R1 is a hydrogen atom or a methyl group; R2a is a hydrogen atom, a protecting group for a hydroxy group, or a methyl group; R3 is a hydrogen atom or a protecting group for a hydroxy group; R4a is a hydrogen atom, a hydroxy group or a protected hydroxy group; R5 is a hydrogen atom or a protecting group for a hydroxy group; and X is a methylene group or a sulfur atom). The invention also includes compounds which are related to the aforeidentified compounds.Type: GrantFiled: January 9, 2001Date of Patent: October 29, 2002Assignee: Sankyo Company, LimitedInventors: Masatoshi Inukai, Masakatsu Kaneko, Toshio Takatsu, Hitoshi Hotoda, Masatoshi Arai, Shunichi Miyakoshi, Masaaki Kizuka, Yasumasa Ogawa
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Patent number: 6469165Abstract: Polyaminotriazines represented by formula (I) can be prepared by conducting a reduction alkylamination of a tetramethylpiperidone with a diamine represented by formula (IIb), NH2—R—NH2, in the presence of a hydrogenating catalyst, removing the catalyst upon completion of the reaction to obtain an unrefined crude product (A); and, conducting a polycondensation reaction of the unrefined crude product (A) and a dichlorotriazine in an aromatic solvent and in the presence of an inorganic base.Type: GrantFiled: December 27, 1994Date of Patent: October 22, 2002Assignee: Sumitomo Chemical Company, LimitedInventors: Kenji Kimura, Shinya Tanaka, Manji Sasaki
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Patent number: 6465645Abstract: Hindered amine compounds which are substituted by a long hydrocarbon chain are useful in a number of applications where the solubility or compatibility afforded by said substitution is needed. This is seen particularly for example with white, dyed, dipped, unscented and/or scented candle wax which is effectively stabilized against discoloration and fading by the incorporation therein of a long chain hindered amine alone or in combination with a UV absorber and/or an antioxidant.Type: GrantFiled: April 17, 2001Date of Patent: October 15, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Mervin G. Wood, Andrea R. Smith, James P. Galbo
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Publication number: 20020147181Abstract: This invention concerns the compounds of formula 1Type: ApplicationFiled: November 15, 2001Publication date: October 10, 2002Inventors: Paul A.J. Janssen, Jan Heeres, Henri E.L. Moereels, Michael Joseph Kukla, Donald W. Ludovici
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Patent number: 6451737Abstract: The invention related to novel substituted arylsulphonyl(thio)ureas wherein: A is nitrogen or a CH grouping, Q is oxygen or sulphur, R1 is hydrogen, halogen or optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy or heterocyclyloxy, R2 is hydrogen, halogen or optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy or heterocyclyloxy, R3 is hydrogen or optionally substituted alkyl, R4 is optionally substituted alkyl, alkoxy, alkenyl, alkinyl, alkenyloxy, alkinyloxy, cycloalkyl, cycloalkyloxy or cycloalkylalkyl, and R5 is hydrogen, formyl or optionally substituted alkyl, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, alkenyl, alkinyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulphonyl or heterocyclyl, and salts of compounds of the formula (I), except for the compound N-(4,6-dimethyl-pyrimidin-2-yl)-N′-[2-(1,1,2,2-tetrafluoro-ethoxy)-6-methyl-phenylsulphonyl]-urea.Type: GrantFiled: August 28, 1998Date of Patent: September 17, 2002Assignee: Bayer AktiengesellschaftInventors: Ernst Rudolf F. Gesing, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Müller, Mark Wilhelm Drewes, Johannes Rudolf Jansen, Ulrich Philipp, Hans-Jochem Riebel, Otto Schallner, Markus Dollinger, Hans-Joachim Santel
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Patent number: 6444809Abstract: Compounds of formula I wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.Type: GrantFiled: September 22, 2000Date of Patent: September 3, 2002Assignee: Zeneca LimitedInventor: Scott Carson Miller
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Patent number: 6441166Abstract: A product containing 5 to 85% of a group (A-1-a) and/or (A-1-b) and 15 to 95% of a group (A-2), the total sum of the groups (A-1-a), (A-1-b) and (A-2) being 100%, is useful for stabilizing an organic material against degradation induced by light, heat or oxidation.Type: GrantFiled: December 13, 1999Date of Patent: August 27, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Dario Lazzari, Graziano Zagnoni, Stephen Mark Andrews
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Publication number: 20020103195Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-&bgr; activity.Type: ApplicationFiled: October 31, 2001Publication date: August 1, 2002Applicant: CELL THERAPEUTICS,INC.Inventors: Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
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Publication number: 20020103201Abstract: This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.Type: ApplicationFiled: January 3, 2002Publication date: August 1, 2002Applicant: Synaptic Pharmaceutical CorporationInventors: Mohammad R. Marzabadi, Stewart A. Noble, Mahesh N. Desai
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Patent number: 6420313Abstract: The invention relates to novel thienylalkylamino-1,3,5-triazines of the general formula (I) in which A, R1, R2, R3, R4, R5 and Z are as defined in the description, to processes for their preparation, to their use as herbicides and to novel intermediates and their preparation.Type: GrantFiled: November 30, 2000Date of Patent: July 16, 2002Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem, K.K.Inventors: Rolf Kirsten, Hans-Jochem Riebel, Stefan Lehr, Katharina Voigt, Kristian Kather, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Yukiyoshi Watanabe, Toshio Goto
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Patent number: 6409941Abstract: A product obtainable by transferring groups of formula (G-I) being present in a block oligomer having a polydispersity {overscore (M)}w/{overscore (M)}n of 1 to 1.7 and corresponding to formula (I) to groups of formula (Gu-II), wherein R1 is a hydrocarbyl radical or —O—R1 is oxyl; said transfer is carried out by reaction of the block oligomer with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst; n is a number from 2 to 14; R2 is for example C2-C12alkylene; A is for example —N(R4)(R5); R4 and R5 are for example C1-C18alkyl; R is preferably a group of formula (G-I) and B and B* have one of the meanings given for A; with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R and R2 has the same or a different meaning. The products are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.Type: GrantFiled: November 18, 1999Date of Patent: June 25, 2002Assignee: Ciba Specialty Chemicals Corp.Inventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli
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Patent number: 6407041Abstract: The invention relaters to compounds of the formula: and their use as herbicides.Type: GrantFiled: July 10, 2000Date of Patent: June 18, 2002Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem, K.K.Inventors: Katharina Voigt, Hans-Jochem Riebel, Stefan Lehr, Andreas Lender, Rolf Kirsten, Markus Dollinger, Mark Wilhelm Drewes, Ingo Wetcholowsky, Yukiyoshi Watanabe, Toshio Goto, Randy Allen Myers
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Patent number: 6403680Abstract: A product obtained by 1) reacting a compound of the formula (&agr;) with a compound of the formula (&bgr;) in a stoichiometric ratio to obtain a compound of the formula (&ggr;) 2) reacting the compound of the formula (&bgr;) with the compound of the formula (&ggr;) in a molar ratio of 0.4:1 to 0.75:1; 3) reacting the end groups of the formula (&dgr;) being present in the product of the reaction 2) with e.g. dibutylamine in a molar ratio of 2:1.7 to 2:3; the reactions 1) to 3) being carried out in an organic solvent in the presence of an inorganic base; and 4) transferring the groups of the formula being present in the product of the reaction 3) to groups of the formula said transfer being carried out by reacting the product of the reaction 3) with a hydroperoxide in a hydrocarbon solvent in the presence of a peroxide decomposing catalyst; R1 is in particular a hydrocarbyl radical, B is e.g.Type: GrantFiled: November 18, 1999Date of Patent: June 11, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli, Ivan Orban
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Patent number: 6399620Abstract: There are described cycloalkyl derivatives of the formula (I) R1—Y—A—B—D—E—F—G (I) in which R1, Y, A, B, D, E, F and G have the meaning indicated herein, their preparation and their use as medicaments. The compounds according to the invention can be used as vitronectin receptor antagonists and as inhibitors of bone resorption.Type: GrantFiled: June 29, 2000Date of Patent: June 4, 2002Assignee: Aventis Pharma S.A.Inventors: Volkmar Wehner, Jochen Knolle, Hans Ulrich Stilz, Jean-Francois Gourvest, Denis Carniato, Thomas Richard Gadek, Robert McDowell, Robert Maurice Pitti, Sarah Catherine Bodary
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Patent number: 6388072Abstract: Hindered amines substituted on the N-atom with an —O—E—OH moiety are particularly effective in stabilizing polyolefin and automotive coating compositions against the deleterious effects of oxidative, thermal and actinic radiation where the presence of the OH group on the compounds adds important properties not attainable by the use of normal —O—E moieties.Type: GrantFiled: February 21, 2001Date of Patent: May 14, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: James P. Galbo, Gerald A. Capocci, Nancy N. Cliff, Robert E. Detlefsen, Michael P. DiFazio, Ramanathan Ravichandran, Peter Solera
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Patent number: 6384032Abstract: The invention relates to a compound of formula (I) which can inhibit the production of IL-12. Also disclosed is a method of inhibiting IL-12 production by administering to a patient in need thereof an effective amount of a compound of formula (I).Type: GrantFiled: June 15, 2000Date of Patent: May 7, 2002Assignee: Shionogi Bioresearch Corp.Inventors: Mitsunori Ono, Yumiko Wada, Beatrice Brunkhorst, Tadeusz Warchol, Wojciech Wrona, Dan Zhou, Nha Huu Vo, Stephen Gillies
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Publication number: 20020049212Abstract: A compound of the formula: 1Type: ApplicationFiled: January 3, 2001Publication date: April 25, 2002Inventors: Fumitaka Ito, Hirohide Noguchi, Yoriko Ohashi, Hirohisa Shimokawa
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Patent number: 6372729Abstract: This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR4 or N; n is 0, 1, 2, 3 or 4; R1 and R2 are each independently selected from hydrogen, hydroxy, C1-12alkyl, C1-12alkyloxy, C1-12alkylcarbonyl, C1-12alkyloxycarbonyl, aryl, amino, mono- or di(C1-12alkyl)amino, mono- or di(C1-12alkyl)aminocarbonyl wherein each of the aforementioned C1-12alkyl groups may optionally and each individually be substituted; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-12alkyl)aminoC1-4alkylidene; R3 is hydrogen, aryl, C1-6alkylcarbonyl, optionally substituted C1-6alkyl; and each R4 independently is hydroxy, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is —X—R5 or —X-Alk-R6; wherein R5 and R6 each independently are indanyl, indolyl or phenyl; each ofType: GrantFiled: August 8, 2000Date of Patent: April 16, 2002Assignee: Janssen Pharmaceutica N.V.Inventors: Frederik Frans Desiré Daeyaert, Bart De Corte, Marc René De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
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Patent number: 6372435Abstract: The present invention provides methods of correlating genetic variants in the beta-chemokine receptor 5 (CCR5) locus, more specifically CCR5 promoter alleles and genotypes, with HIV-1 transmission and/or disease progression in individuals and populations.Type: GrantFiled: August 11, 2000Date of Patent: April 16, 2002Assignee: UAB Research FoundationInventors: Richard A. Kaslow, Jianming Tang
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Patent number: 6372743Abstract: Disclosed are compounds of the formula: where R1, R2, R3, R4, R5, R6, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.Type: GrantFiled: September 29, 2000Date of Patent: April 16, 2002Assignees: Neurogen Corporation, Pfizer Inc.Inventors: James W. Darrow, Stephane De Lombaert, Charles Blum, Jennifer Tran, Mark Giangiordano, David Andrew Griffith, Philip Albert Carpino
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Patent number: 6346503Abstract: The invention relates to novel substituted 2-amino-4-alkylamino-1,3,5-triazines of the formula (I) in which R1 represents in each case optionally substituted alkyl having 2 to 6 carbon atoms or cycloalkyl having 3 to 6 carbon atoms, R2 represents hydrogen or represents alkyl having 1 to 4 carbon atoms, A represents oxygen or methylene, Ar represents in each case optionally substituted phenyl, naphthyl or heterocyclyl, and Z represents hydrogen, represents halogen or represents in each case optionally substituted alkyl, alkoxy, alkylcarboxyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, alkenyl or alkinyl, to processes and to novel intermediates for their preparation and to their use as herbicides.Type: GrantFiled: April 6, 1999Date of Patent: February 12, 2002Assignee: Bayer AktiengesellschaftInventors: Hans-Jochem Riebel, Stefan Lehr, Uwe Stelzer, Yukiyoshi Watanbe, Markus Dollinger