Hetero Ring Patents (Class 544/209)
  • Patent number: 6346531
    Abstract: Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compounds.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: February 12, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Juan I Luengo, Kevin J Duffy
  • Patent number: 6340683
    Abstract: This invention is directed to triazine derivatives which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: January 22, 2002
    Assignee: Synaptic Pharmaceutical Corporation
    Inventors: Mohammad R. Marzabadi, Stewart A. Noble, Mahesh N. Desai
  • Patent number: 6326368
    Abstract: The present invention provides novel compounds, and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsey, irritable bowl syndrome, immune supression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R5, Q, Z, Y, V, X and X′ are as defined herein.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: December 4, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Robert John Chorvat, Parthasarathi Rajagopalan
  • Patent number: 6303541
    Abstract: The invention relates to novel substituted thienyl(amino)sulphonyl(thio)ureas of the formula (I) in which A represents nitrogen or a CH grouping, E represents a single bond or an NH grouping, Q represents oxygen or sulphur, R1 and R2 independently of one another represent hydrogen, halogen or in each case optionally substituted alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, cycloalkyl, cycloalkyloxy, aryloxy or heterocyclyloxy, R3 represents hydrogen or optionally substituted alkyl, R4 and R5 independently of one another each represent cyano, halogen or represent in each case optionally substituted alkyl, alkoxy, alkenyl, alkenyloxy, alkinyl or alkinyloxy, and R6 represents hydrogen, cyano, halogen or represents in each case optionally substituted alkyl, alkoxy, alkenyl, alkenyloxy, alkinyl or alkinyloxy, and to salts of compounds of the formula (I), to processes for preparing the novel compounds and to their use as herbicides.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: October 16, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ernst Rudolf F. Gesing, Johannes Rudolf Jansen, Klaus-Helmut Müller, Ulrich Philipp, Markus Dollinger
  • Patent number: 6297299
    Abstract: Compounds of the formula (I) in which the polydispersity {overscore (M)}w/{overscore (M)}n is 1; n is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15; the radicals R1 are for example hydrogen or C1-C8alkyl; R2 is for example C2-C12alkylene; the radicals A are independently of one another —OR3, —N(R4)(R5) or a group of the R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of the formula with Y being —O—, —CH2—, —CH2CH2— or >N—CH3; X is —O— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; R is preferably a group of the formula and the radicals B have independently of one another one of the definitions given for A; with the proviso that in the individual recurrent units of the formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning, are useful as ligh
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: October 2, 2001
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Valerio Borzatta, Fabrizio Guizzardi
  • Patent number: 6288228
    Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: September 11, 2001
    Assignee: Abbott Laboratories
    Inventors: Jack Henkin, Donald J. Davidson, George S. Sheppard, Keith W. Woods, Richard W. McCroskey
  • Patent number: 6284710
    Abstract: The invention relates to novel substituted 2-amino-4-alkylamino-1,3,5-triazines of the formula (I) in which R1 represents optionally substituted methyl, R2 represents hydrogen or alkyl, Y represents in each case optionally substituted benzyl, naphthylmethyl, heterocyclylmethyl or heterocyclyloxy, and Z represents hydrogen, represents halogen or represents in each case optionally substituted alkyl, alkoxy, alkylcarboxyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, alkenyl or alkinyl, to processes and to novel intermediates for their preparation and to their use as herbicides.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: September 4, 2001
    Assignees: Bayer Aktiengesellschaft, Nihon Bayer Agrochem K.L.
    Inventors: Hans-Jochem Riebel, Stefan Lehr, Uwe Stelzer, Yukiyoshi Watanabe, Markus Dollinger, Peter Dahmen, Seishi Ito, Toshio Goto, Akihiko Yanagi
  • Patent number: 6271178
    Abstract: The invention relates to novel substituted 2,4-diamino-1,3,5-triazines of the formula (I) In which R1 represents hydrogen or optionally substitued alkyl, R2 represents formyl or represents in each case optionally substituted alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, arylcarbonyl or arylsulphonyl, R3 represents in each case optionally substituted alkyl or cycloalkyl, R4 represents hydrogen or alkyl, A represents oxygen or methylene, Ar represents in each case optionally substituted aryl or heterocyclyl, and z represents hydrogen, hydroxyl, cyano, nitrogen, halogen or represents in each case optionally substituted alkyl, alkoxy, alkylcarbonyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, alkenyl or alkinyl, (except for three prior-art compounds), to processes and to novel intermediates for preparation of the novel compounds and to their use as herbicides.
    Type: Grant
    Filed: April 7, 1999
    Date of Patent: August 7, 2001
    Assignees: Bayer AG, Nihon Bayer Agrochem K.K.
    Inventors: Hans-Jochem Riebel, Stefan Lehr, Uwe Stelzer, Yukiyoshi Watanabe, Markus Dollinger, Toshio Goto
  • Patent number: 6265473
    Abstract: Compounds of formula (I), in which the polydispersity Mw/Mn is for example 1; n is 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 the radicals R1 are for example C1-C18alkyl or C5-C12cycloalkyl; R2 is for example C-Cl2alkylene; the radicals A and B* are independently of one another —OR3, —N(R4)(R5) or a group of formula (II); R3, R4 and R5, which are identical or different, are for example hydrogen or C1-C18alkyl, or —N(R4)(R5) is additionally a group of formula (III) with Y being —0—, —CH2—, —CH2, —CH2— or >N—CH3; X is —0— or >N—R6; R6 is for example hydrogen or C1-C18alkyl; R is preferably a group of formula (IV); and B has one of the meanings given for A; with the proviso that in the individual recurrent units of formula (I), each of the radicals B, R, R1 and R2 has the same or a different meaning.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: July 24, 2001
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: James Peter Galbo, Nicola Lelli, Valerio Borzatta, Jean-Pierre Wolf, Michael Ackerman, Piero Piccinelli
  • Patent number: 6265348
    Abstract: Compounds of the formula (I) and salts thereof in which R1 to R6, W, X, Y and Z are defined as in claim 1, have herbicidal or plant growth-regulatory properties. They can be prepared by processes analogous to known processes (cf. claim 5), in some cases via novel intermediate products (cf.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: July 24, 2001
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Heinz Kehne, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6254669
    Abstract: A compound of the Formula (1) and salts thereof: wherein: Ar, Ar1, J, J1, X, X1 W, W1, L and m are as defined in the description. The compounds of Formula (1) are useful as additives in inks, especially ink jet printing inks, for reducing color bleed between adjacent printed regions. Also claimed are inks containing a compound of the Formula (1), a method of ink jet printing using the inks, a substrate printed with the ink and an ink jet printer cartridge containing the ink.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: July 3, 2001
    Assignee: Zeneca Limited
    Inventors: Aidan Joseph Lavery, Prahalad Manibhai Mistry, Ronald Wynford Kenyon
  • Patent number: 6251900
    Abstract: Heterocyclic compounds in which s-triazine or pyrimidine is substituted with benzimidazole and morpholine and which are represented by the Formula I or phermaceutically acceptable acid addition salts thereof: wherein X and Y respectively represent nitrogen atom or one of them represents nitrogen atom and the other represents C—R7 wherein R7 represents hydrogen or halogen atom; R1, R2, R4, R5 and R6 represent hydrogen atom or C1-C6 alkyl; R3 represents morpholino, piperidino, piperazinyl, thiomorpholino, benzimidazolyl, cyano or the like.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: June 26, 2001
    Assignee: Zenyaku Kogyo Kabushiki Kaisha
    Inventors: Seiichiro Kawashima, Toshiyuki Matsuno, Shinichi Yaguchi, Tetsuo Watanabe, Masahiro Inaba
  • Patent number: 6239071
    Abstract: Compounds of the formula (I) and their salts in which R1 is optionally substituted (C1-C6)alkyl or optionally substituted phenyl, A is an optionally substituted hydrocarbon diradical and R2, R3, R4, R5, X and n are as defined in claim 1, are suitable as herbicides and plant growth regulators. The compounds (I) can be prepared according to processes as claimed in claim 6 by means of intermediates which are novel in some cases, e.g. of the formula (IV) as claimed in claim 10.
    Type: Grant
    Filed: August 22, 1996
    Date of Patent: May 29, 2001
    Assignee: Hoecht Schering AgrEvo GmbH
    Inventors: Wolfgang Giencke, Klemens Minn, Lothar Willms, Hermann Bieringer, Klaus Bauer, Christopher Rosinger
  • Patent number: 6200984
    Abstract: A compound of the general formula I: is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions, processes for preparing the compounds and methods of treatment are also disclosed.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: March 13, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Allen B. Reitz, James J. McNally, Pauline Sanfilippo
  • Patent number: 6191131
    Abstract: Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: February 20, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Liqi He, Paul Gilligan, Robert Chorvat, Argyrios Georgios Arvanitis
  • Patent number: 6174940
    Abstract: The present invention relates to mixtures comprising the compound I in a proportion of 65-95% by weight, the compound II in a proportion of 5-35% by weight and the compound III in a proportion of 0-10% by weight wherein the substituents are as defined in the description, and to mixtures with other compounds. The mixtures are suitable for stabilizing organic material against the effect of light and heat.
    Type: Grant
    Filed: August 13, 1998
    Date of Patent: January 16, 2001
    Assignee: Clariant GmbH
    Inventors: Thomas St{umlaut over (a)}hrfeldt, Mathias Mehrer, Matthias Z{umlaut over (a)}h, Gerhard Pfahler
  • Patent number: 6150360
    Abstract: This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR.sup.4 or N; n is 0, 1, 2, 3 or 4; R.sup.1 and R.sup.2 are each independently selected from hydrogen, hydroxy, C.sub.1-12 alkyl, C.sub.1-12 alkyloxy, C.sub.1-12 alkylcarbonyl, C.sub.1-12 -alkyloxycarbonyl, aryl, amino, mono- or di(C.sub.1-12 alkyl)amino, mono- or di(C.sub.1-12 alkyl)aminocarbonyl wherein each of the aforementioned C.sub.1-12 alkyl groups may optionally and each individually be substituted; or R.sup.1 and R.sup.2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C.sub.1-12 alkyl)aminoC.sub.1-4 alkylidene; R.sup.3 is hydrogen, aryl, C.sub.1-6 alkylcarbonyl, optionally substituted C.sub.1-6 alkyl; and each R.sup.4 independently is hydroxy, halo, C.sub.1-6 alkyl, C.sub.1-6 -alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is --X--R.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: November 21, 2000
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Frederik Frans Desire Daeyaert, Bart De Corte, Marc Rene De Jonge, Jan Heeres, Chih Yung Ho, Paul Adriaan Jan Janssen, Robert W. Kavash, Lucien Maria Henricus Koymans, Michael Joseph Kukla, Donald William Ludovici
  • Patent number: 6136827
    Abstract: The present invention is directed to cyclic amines of the formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: October 24, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Charles G. Caldwell, Paul E. Finke, Malcolm Maccoss, Laura C. Meurer, Sander G. Mills, Bryan Oates
  • Patent number: 6120562
    Abstract: Amino- and/or alkoxytriazines containing at least one C.sub.1 -C.sub.10 -alkyl group which possesses a vinylsulfonyl group or a radical capable of forming a vinylsulfonyl group and may be substituted further, are used as fixation aids when using anionic dyes on hydroxyl- or nitrogen-containing organic substrates and as crosslinkers for regenerated cellulose or materials containing cellulose.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: September 19, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Manfred Patsch, Reinhold Krallmann, Wolfgang Reuther, Thomas Grosser
  • Patent number: 6114420
    Abstract: A compound of the formula (I) ##STR1## wherein n is an integer from 1 to 4; the radicals R.sub.1 are for example a group of the formula ##STR2## R.sub.3 is for example hydrogen, C.sub.1 -C.sub.8 alkyl or C.sub.5 -C.sub.12 cycloalkoxy; Z and R.sub.2 are for example a group ##STR3## the radicals A and E are, for example, independently of one another --N(R.sub.11)(R.sub.12) or a group of the formula ##STR4## R.sub.11 and R.sub.12 are for example C.sub.1 -C.sub.12 alkyl; R.sub.13 has for example one of the meanings given for R.sub.3 ; E* has for example one of the meanings given for A or is a group of the formula ##STR5## The compounds of the formula (I) are useful as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers such as polyolefins.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: September 5, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Alessandro Zedda, Gianluca Ferri
  • Patent number: 6069114
    Abstract: Compounds of the formula (I) and their salts ##STR1## in which R.sup.1 to R.sup.6, Y.sup.1, to Y.sup.2, Y.sup.3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepared analogously to known processes using intermediates of the formula (V) (cf. claim 6).
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: May 30, 2000
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Klemens Minn, Lothar Willms, Klaus Bauer, Hermann Bieringer, Christopher Rosinger
  • Patent number: 6046304
    Abstract: Compounds of the formula (I) ##STR1## in which the polydispersity Mw/Mn is 1; n is 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15; the radicals R.sub.1 are for example hydrogen or C.sub.1 -C.sub.8 alkyl; R.sub.2 is for example C.sub.2 -C.sub.12 alkylene; the radicals A are independently of one another --OR.sub.3, --N(R.sub.4)(R.sub.5) or a group of the formula ##STR2## R.sub.3, R.sub.4 and R.sub.5, which are identical or different, are for example hydrogen or C.sub.1 -C.sub.18 alkyl,or --N(R.sub.4)(R.sub.5) is additionally a group of the formula ##STR3## with Y being --O--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or >N--CH.sub.3 ; X is --O-- or >N--R.sub.6 ; R.sub.6 is for example hydrogen or C.sub.1 -C.sub.18 alkyl; R is preferably a group of the formula ##STR4## and the radicals B have independently of one another one of the definitions given for A; with the proviso that in the individual recurrent units of the formula (I), each of the radicals B, R, R.sub.1 and R.sub.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: April 4, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Valerio Borzatta, Fabrizio Guizzardi
  • Patent number: 6036731
    Abstract: The process for crosslinking cellulosic fiber materials, especially cellulosic fiber materials which are 20 to 100% by weight natural or regenerated cellulose fibers, comprises applying to the cellulosic fiber materials in which the cellulosic fibers comprise natural or regenerated cellulose at least one product of the general formula (1) ##STR1## where A is a colorless aliphatic, aromatic or heteroaromatic radical, R is a fiber-reactive radical and n is 1, 2, 3 or 4, with the proviso that the radical [R].sub.n includes at least two fiber-reactive groups, and is useful for achieving permanent finish effects, for example in the area of easy care, dimensional stability and shrink resistance.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: March 14, 2000
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Peter Scheibli, Peter Aeschlimann
  • Patent number: 6013797
    Abstract: At least bis-imido 1,3,5-triazines and processes of preparing the same are disclosed. Also disclosed are prepolymers having at least bis-imido functionality and curable compositions comprising at least bis-imido 1,3,5-triazines or prepolymers thereof in combination with active hydrogen and/or epoxy functional materials. The at least bis-imido 1,3,5-triazines and prepolymers may be advantageously employed as crosslinking agents which crosslink by a ring opening reaction that eliminates the release of volatile organic compounds.
    Type: Grant
    Filed: March 20, 1998
    Date of Patent: January 11, 2000
    Assignee: Cytec Technology Corp.
    Inventors: Lon-Tang Wilson Lin, Robert G. Lees, William F. Jacobs, III, Subban Ramesh
  • Patent number: 5972248
    Abstract: The present invention relates to novel stabilizers of the formula (I) ##STR1## in which the substituents have the meaning defined in the description. These novel stabilizers are particularly suitable for stabilizing organic material, such as plastics, oils, paints and coatings, against degradation by light, radiation, heat and oxygen.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: October 26, 1999
    Assignee: Clariant GmbH
    Inventors: Thomas Stahrfeldt, Josef Wiedemann, Matthias Zah
  • Patent number: 5968482
    Abstract: The invention relates to the use of .alpha.-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the .alpha.-hydroxyketoalkyl group being linked, if appropriate via a spacer, to a chromophoric group which has an absorption maximum in a wavelength range of between 280 and 400 nm and has a conjugated .pi.-electron system of at least 8 .pi.-electrons, and to new .alpha.-hydroxyalkyl derivatives, processes for their preparation and pharmaceutical and cosmetic formulations comprising these derivatives as light protection substances.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: October 19, 1999
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Roland Martin, Ingeborg Stein, Ulrich Heywang, Michael Schwarz, Thekla Kurz
  • Patent number: 5969134
    Abstract: Carboxylic acid derivatives ##STR1## where R-R.sup.6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: October 19, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Hartmut Riechers, Dagmar Klinge, Wilhelm Amberg, Andreas Kling, Stefan Muller, Ernst Baumann, Joachim Rheinheimer, Uwe Josef Vogelbacher, Wolfgang Wernet, Liliane Unger, Manfred Raschack
  • Patent number: 5965641
    Abstract: A description is given of a process for stabilising an organic polymer against ozone in the ambient air, which comprises adding to the polymer as stabiliser a monomeric sterically hindered piperidine compound, or an oligomeric or polymeric sterically hindered piperidine compound containing one or several triazine units, or a secondary sterically hindered piperidine compound, the piperidine compound containing in any case at least one unit of formula I ##STR1## wherein G is hydrogen or methyl, and G.sub.1 and G.sub.2 are hydrogen, methyl or, taken together, oxygen.With this process it is possible to make a more accurate prediction of the service time of the polymer and it helps to avoid unnecessarily high dosages of the stabiliser.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: October 12, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Fran.cedilla.ois Gugumus
  • Patent number: 5948910
    Abstract: Water-soluble perylene dyestuffs, their preparation and their useThe present Application relates to water-soluble perylene dyestuffs of the formula ##STR1## in which R.sup.1 and R.sup.2 independently of one another are the radicals A--X--COOM or A--X--SO.sub.3 M;R.sup.3 and R.sup.4 independently of one another are the radicals R.sup.1 or R.sup.2, or are OR.sup.5 or NR.sup.6 R.sup.7 ;A is NR.sup.8 or S;X is a straight-chain or branched alkylene radical, a straight-chain or branched alkylene radical which is substituted by hydroxyl, carboxyl or amino, an arylene radical or an arylene radical which is optionally substituted by hydroxyl, carboxyl or sulfo;R.sup.5, R.sup.6 and R.sup.7 independently of one another are hydrogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkyl which is substitituted by one or more hydroxyl, 2-hydroxyethoxy, (C.sub.1 -C.sub.4)-alkoxy or amino groups;R.sup.
    Type: Grant
    Filed: September 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Clariant GmbH
    Inventors: Wolfgang Bauer, Dieter Baumgart, Dieter Schnaitmann, Klaus-Peter Kreutzer, Walter Zoller
  • Patent number: 5936085
    Abstract: Disclosed and claimed is a process for the preparation of a carbamate (IV)Ar--O--CO--NR--B (IV)by reaction of a saltM.sup..sym. .crclbar.NR--B (II-S)with a diaryl carbonate(ArO).sub.2 CO (III).The carbamate can be reacted, without any necessity of intermediate isolation, with a sulfonamide A--SO.sub.2 NH.sub.2 (V) to give a sulfonylurea (I) or salts thereofA--SO.sub.2 --NH--CO--NR--B (I).And thus, disclosed and claimed too is a process for the preparation of sulfonylurea (I) by (i) contacting a salt (II-S) with a diaryl carbonate (III) to form a carbamate (IV), and (ii) contacting carbamate (IV) from step (i) with or without intermediate isolation, with a sulfonamide (V). These processes avoid the use of alkali metal hydrides as a base. And, these processes can additionally include the preparation of salt (II-S) from a compound H--NR--B (II) and base M.sup..sym. Base.sup..crclbar..
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: August 10, 1999
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Gerhard Schnabel, Harald Knorr, Klemens Minn, Jan Vermehren
  • Patent number: 5931975
    Abstract: Dyes of the formula ##STR1## in which A.sub.1 and A.sub.2 independently of one another are the radical of a monoazo, polyazo, metal complex azo, anthraquinone, phthalocyanine, formazan, azomethine, dioxazine, phenazine, stilbene, triphenylmethane, xanthene, thioxanthone, nitroaryl, naphthoquinone, pyrenequinone or perylenetetracarbimide dye,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently of one another are hydrogen or substituted or unsubstituted C.sub.1 -C.sub.4 alkyl,Y.sub.1 and Y.sub.2 independently of one another are halogen, carboxypyridinium, substituted or unsubstituted amino or a heterocyclic radical bonded via a nitrogen atom andn is a number from 1 to 7,are particularly suitable for dyeing or printing fiber materials containing hydroxyl groups or nitrogen. Dyeings with good fastness properties are obtained with a high dyeing yield.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: August 3, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Bernhard Muller, Patric Nowack
  • Patent number: 5925597
    Abstract: Compounds of the formula (I) and their salts as defined in claim 1, ##STR1## in which R.sup.1 is CO--Q--R.sup.8, where R.sup.8 =H or RR.sup.2 and R.sup.3 are H or (C.sub.1 -C.sub.4)alkyl,R.sup.4 is H, R, RO, OH, RCO, RSO.sub.2, PhSO.sub.2R.sup.5 is RSO.sub.2, PhSO.sub.2, PhCO, RNHSO.sub.2, R.sub.2 NSO.sub.2, RCO, CHO, COCOR', CW--T--R.sup.9, CW--NR.sup.10 R.sup.11, CW--N(R.sup.12).sub.2 orR.sup.4 and R.sup.5 together are the chain (CH.sub.2).sub.m B or --B.sup.1 --(CH.sub.2).sub.m1 B-- where B=SO.sub.2, CO; m=3, 4; m.sup.1 =2, 3;T and W=O, S; Q=O, S, NR.sup.13 where R.sup.13 =H, R;R.sup.6 =H, R, RO, RCO, ROCO, Hal, NO.sub.2, CN;R.sup.7 =H, CH.sub.3 ; R.sup.9 =R; R.sup.10, R.sup.11 =H, R; N(R.sup.12).sub.2 =heterocycleA=pyrimidinyl and triazinyl radical or an analog thereof,where R=(substituted) aliphatic hydrocarbon radical, are suitable as selective herbicides. They are prepared by analogous processes via sulfonamides, some of which are new, of the formula (II).
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: July 20, 1999
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Klaus Lorenz, Lothar Willms, Klaus Bauer, Hermann Bieringer
  • Patent number: 5922122
    Abstract: A composition containing an organic pigment and a compound having the formula (I): ##STR1## in which R.sup.1 is a group having the formula (II): ##STR2## in which R.sup.4 and R.sup.5 represent hydrogen or alkyl, or R.sup.4 and R.sup.5 are bonded to each other to form a ring together with a nitrogen atom, X represents alkylene or alkyleneoxyalkylene, and Y represents --O--, --S-- or a group represented by --NR.sup.6 -- wherein R.sup.6 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 represent a group having the formula (II), alkyl, aralkyl, aryl, alkoxy, aralkyloxy, aryloxy, alkylamino, arylamino or a halogen atom. A photosensitive colored composition is made of the composition, a polymer having acidic group, a photopolymerizable monomer and a photopolymerization initiator.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 13, 1999
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Akihiko Takeda, Takekatsu Sugiyama
  • Patent number: 5919929
    Abstract: A process for the preparation of a product corresponding to the formula (I) ##STR1## wherein n is a number from 2 to 50; the radicals R.sub.1 are for example 2,2,6,6-tetramethyl-4-piperidyl, R.sub.2 is for example hexamethylene and E is for example t-octylamino; which comprisesa) reacting a compound of the formula (A) ##STR2## with a compound of the formula (B) ##STR3## in a molar ratio of 1:1.7 to 1:4; and b) reacting the product obtained in a) with a compound of the formula (C) ##STR4## to obtain the product corresponding to the formula (I), the molar ratio of the compound of the formula (C) to the compound of the formula (A) being 2:1 to 1:5; the reactions a) and b) being carried out in an organic solvent, in the presence of an inorganic base and in an inert atmosphere.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: July 6, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Marco Tomei
  • Patent number: 5885935
    Abstract: Herbicidal sulfonamides of the formula: ##STR1## and salts thereof, where: A represents a substituted or unsubstituted benzene ring, or a 5- or 6-membered substituted or unsubstituted heteroaromatic ring; Q is --O--, --S-- or a group --CXX'--; X and X', which may be the same or different, are each hydrogen, halogen, cyano, an optionally-substituted alkyl group, or a group --OR.sup.a, --SR.sup.a, or --COR.sup.b ; or one of X and X' represents hydroxy and the other is as defined above; or X and X' together represent .dbd.O or .dbd.S; R.sup.a is an optionally-substituted alkyl, aryl or acyl group; R.sup.b is an optionally-substituted alkyl or aryl group, or a group --OR.sup.c or --NR.sup.c R.sup.d ; R.sup.c and R.sup.d, which may be the same or different, are each hydrogen, or an optionally-substituted alkyl or aryl group; Y is nitrogen or a group CR.sup.9 ; R.sup.1 is an optionally-substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, benzoheterocyclyl or amino group; R.sup.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: March 23, 1999
    Assignee: Agrevo UK Limited
    Inventors: Peter Stuart Gates, Graham Peter Jones, David Edward Saunders
  • Patent number: 5886176
    Abstract: The invention relates to a novel process for preparing herbicidal sulphonylurea salts of the formula (I) ##STR1## in which M.sup.+ represents an alkali metal ion or an alkaline earth metal ion equivalent,Z represents N, CH or C-halogen,R.sup.1 represents in each case optionally substituted aryl, aralkyl or heteroaryl,(where R.sup.2, X and Y have the meanings given in the description).
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: March 23, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventor: Klaus-Helmut Muller
  • Patent number: 5852015
    Abstract: This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: December 22, 1998
    Assignee: American Cyanamid Company
    Inventors: Yakov Gluzman, deceased, James P. LaRocque, Bryan M. O'Hara, John E. Morin, George A. Ellestad, Boris Mitsner, Wei-Dong Ding, Yuri E. Raifeld, Antonina A. Nikitenko
  • Patent number: 5847132
    Abstract: Compounds of the formula (I) ##STR1## wherein n is a number from 1 to 20;the radicals R.sub.1 are independently of one another hydrogen, C.sub.1 -C.sub.8 alkyl, --O, --OH, --CH.sub.2 CN, C.sub.1 -C.sub.18 alkoxy, C.sub.5 -C.sub.12 cycloalkoxy, C.sub.3 -C.sub.6 alkenyl, C.sub.7 -C.sub.9 phenylalkyl which is unsubstituted or substituted on the phenyl by 1, 2 or 3 C.sub.1 -C.sub.4 alkyl; or C.sub.1 -C.sub.8 acyl;R.sub.2 has one of the meanings given for R.sub.1 ;X is C.sub.2 -C.sub.10 alkylene; andY is --O-- or >NH;with the proviso that in the individual recurrent units of the formula (I), each of the radicals R.sub.1, R.sub.2, X and Y has the same or different definitions;are very effective as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials, in particular synthetic polymers.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 8, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Valerio Borzatta, Fabrizio Guizzardi, Nicola Lelli
  • Patent number: 5840893
    Abstract: There is disclosed compound according to the formula: ##STR1## wherein A, independently,=CH.sub.3 or CH.sub.2 CH.sub.3, P=1 or 2; and ##STR2## wherein X=NH.sub.2, CH.sub.3 or CH.sub.2 CH.sub.3 ; X'=CH.sub.3 or CH.sub.2 CH.sub.3 ; Y=NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 ; and Z=H, CH.sub.3 or CH.sub.2 CH.sub.3 ; or ##STR3## wherein Y' and Z', independently,=H, NH.sub.2, NHCH.sub.3, N(CH.sub.3).sub.2 or N.sup.+ (CH.sub.3).sub.3 ; Q is N or CH; and salts thereof.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: November 24, 1998
    Assignee: The Picower Institute for Medical Research
    Inventors: Michael I. Bukrinsky, Anthony Cerami, Peter Ulrich, Bradley J. Berger
  • Patent number: 5824624
    Abstract: New herbicidal pyridine and pyrimidine derivatives of general formula (I), ##STR1## wherein Z represents a nitrogen atom or a C--H group; A represents an optionally substituted aryl group or an optionally substituted 5- or 6-membered nitrogen-containing heteroaromatic group; n represents an integer from 0 to 2 and R.sup.1 or each R.sup.1 independently represents a hydrogen atom or an optionally substituted alkyl, alkoxy, alkylthio or dialkylamino group; m represents an integer from 0 to 5 and R.sup.2 or each R.sup.2 independently represents a hydrogen or a halogen atom or an optionally substituted alkyl, haloalkyl, haloalkoxy, alkoxy, alkylthio group or a nitro, cyano or a halosulphonyl group; and X represents an oxygen or sulphur atom.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: October 20, 1998
    Assignee: American Cyanamid Company
    Inventors: Axel Kleeman, Helmut Siegfried Baltruschat, Thelka Hulsen
  • Patent number: 5807929
    Abstract: At least bis-imido 1,3,5-triazines and processes of preparing the same are disclosed. Also disclosed are prepolymers having at least bis-imido functionality and curable compositions comprising at least bis-imido 1,3,5-triazines or prepolymers thereof in combination with active hydrogen and/or epoxy functional materials. The at least bis-imido 1,3,5-triazines and prepolymers may be advantageously employed as crosslinking agents which crosslink by a ring opening reaction that eliminates the release of volatile organic compounds.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 15, 1998
    Assignee: Cytec Technology Corp.
    Inventors: Lon-Tang Wilson Lin, Robert G. Lees, William F. Jacobs, III, Subban Ramesh
  • Patent number: 5792222
    Abstract: Process for dyeing natural or synthetic polyamide fiber materials, which comprises dyeing these fiber materials with at least one anionic acid dye of the formula ##STR1## and treating the fiber material mentioned, during or after the dyeing process, with a colorless fixing agent which contains sulfo or sulfato groups and contains at least two fiber-reactive groups, whereR.sub.1 and R.sub.2 independently of one another are hydrogen or substituted or unsubstituted C.sub.1 -C.sub.4 alkyl,X.sub.1 is substituted or unsubstituted C.sub.1 -C.sub.8 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl or naphthyl, or the radical of the formula --N(R.sub.2)--X.sub.1 is a ring, which may contain further heteroatoms,Y.sub.1 is a radical of the formula ##STR2## in which B.sub.1 is a colorless organic bridge member,R.sub.3 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.4 alkyl andR.sub.4 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.8 alkyl, C.sub.5 -C.sub.7 cycloalkyl, phenyl or naphthyl, andA.sub.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: August 11, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Jean-Marie Adam, Jean-Pierre Bacher, Francine Casi
  • Patent number: 5786475
    Abstract: The invention relates to compounds of formula ##STR1## wherein the variables have the meanings given in the claims. The compounds are suitable for use as UV absorbers for the photochemical stabilization of undyed, dyed or printed textile fiber materials and for enhancing the sun protection factor thereof.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: July 28, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Francesco Fuso, Gerhard Reinert
  • Patent number: 5786476
    Abstract: The invention relates to compounds of formula ##STR1## wherein the variables are as claimed in the claims. The compounds are suitable as UV absorbers for the photochemical stabilisation of undyed or dyed cellulosic fibre materials for enhancing their sun protection factor.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: July 28, 1998
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Francesco Fuso
  • Patent number: 5770544
    Abstract: A condensed heterocyclic derivative of the formula ##STR1## (wherein R is a hydroxyl group, R.sup.3 or R.sup.4 is an alkoxy group, W is an oxygen atom, Yn is a hydrogen atom, Z is a methine group, and A is a 5- or 6-membered heterocyclic ring which may be substituted, and a herbicide, are presented. When used for paddy field treatment, upland soil treatment and foliage treatment, the condensed heterocyclic derivative of the present invention exhibits excellent herbicidal activities against gramineous and non-gramineous weeds without adversely affecting crop plants.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: June 23, 1998
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Sumio Yokota, Masafumi Matsuzawa, Nobuyuki Ohba, Toshihiro Nagata, Shigehiko Tachikawa, Takeshige Miyazawa, Katsutada Yanagisawa
  • Patent number: 5750469
    Abstract: Substituted lactic acid derivatives having an N-organic radical in the .beta.-position, of the formula I ##STR1## where substituents R to R.sup.5, X and Y have the meanings mentioned in the description and N is one of the radicals:a) --N.sub.3, --NC, --NCS or --NCOb) ##STR2## where R.sup.14 and R.sup.15 have the meanings described in the descriptionc) ##STR3## in which R.sup.16 is hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl or unsubstituted or substituted phenyl; andB is a group ##STR4## OR.sup.19 or --NR.sup.14 R.sup.15, where R.sup.14, R.sup.15, R.sup.17 and R.sup.19 have the meanings described in the description, or ##STR5## where R.sup.14 and R.sup.15.sub.1, have the abovementioned meanings; or ##STR6## where R.sup.20 and R.sup.21, which can be identical or different, are: hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or phenyl, where the organic radicals can in each case be substituted;or R.sup.20 and R.sup.21 together form an unsubstituted or substituted C.sub.4 -C.sub.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: May 12, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Ernst Baumann, Joachim Rheinheimer, Uwe Josef Vogelbacher, Matthias Gerber, Wilhelm Rademacher, Helmut Walter, Karl-Otto Westphalen
  • Patent number: 5747423
    Abstract: The novel 6-thienyl pyridines and 4-thienyl pyrimidines of formula I: ##STR1## (A, R.sub.1 to R.sub.5 and Z are defined in the specification) show selective herbicidal activity.The new compounds can be prepared according to known methods and can be used as herbicides in agriculture and related fields.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: May 5, 1998
    Assignee: American Cyanamid Company
    Inventors: Stefan Scheiblich, Thomas Maier, Helmut Siegfried Baltruschat, Joseph Luke Pont
  • Patent number: 5736628
    Abstract: The present invention is directed to novel benzenesulfonylurea derivatives having herbicidal activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 7, 1998
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Dae-Whang Kim, Young Kwan Ko, Jin-Seog Kim, Dong Whan Ku
  • Patent number: 5700295
    Abstract: The invention relates to compounds of formula ##STR1## wherein the variables have the meanings given in the claims. The compounds are suitable for use as UV absorbers for the photochemical stabilisation of undyed, dyed or printed textile fiber materials and for enhancing the sun protection factor thereof.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: December 23, 1997
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Francesco Fuso, Gerhard Reinert
  • Patent number: 5696262
    Abstract: The invention relates to novel water-soluble triazines of formula ##STR1## wherein the variables are as defined in the claims, to a process for their preparation and to the use thereof for the photochemical and thermal stabilisation of dyed or undyed polyamide fiber materials.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: December 9, 1997
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Francesco Fuso, Gerhard Reinert