Plural Benzothiazoles (including Hydrogenated) Patents (Class 548/156)
  • Patent number: 11427575
    Abstract: A compound as shown in formula I. R1 is selected from the group consisting of —OH, —CH3, —CH2CH3, —OCH3, —OCH2CH3; R2 is selected from the group consisting of —H, —OH, —CH3, —CH2CH3, —CH2CH2CH3, —OCH3, —OCH2CH2CH3; R3 is selected from the group consisting of —F, —Cl, —Br, —I, —CF3; R4 is selected from the group consisting of —H, —F, —Cl, —Br, —I, —CF3; and R5 is selected from the group consisting of —H, —CH3, —CH2CH3.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: August 30, 2022
    Assignee: SIMCERE PHARMACEUTICAL CO., LTD.
    Inventor: Jianwei Zhou
  • Patent number: 11022904
    Abstract: Provided an electrophotographic member having an excellent electroconductivity and being capable of forming a high quality electrophotographic image even in long-term use. The electrophotographic member comprises an electroconductive substrate and an electroconductive layer on the substrate, the electroconductive layer containing a matrix polymer, and a specific imidazolium salt.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: June 1, 2021
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Hideya Arimura, Masaki Yamada, Hiroaki Komatsu
  • Patent number: 9855276
    Abstract: The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: January 2, 2018
    Assignee: The General Hospital Corporation
    Inventor: David R. Elmaleh
  • Patent number: 9097667
    Abstract: The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: F—Y=???Formula II and wherein Z— is a counterion, Y is a bridge unit permitting electron delocalization between F and ?, and F is a moiety having the structure: The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: August 4, 2015
    Assignee: BIOTIUM, INC.
    Inventors: Fei Mao, Wai-Yee Leung, Ching-Ying Cheung, Hye Eun Hoover
  • Patent number: 9089603
    Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 28, 2015
    Assignee: LI-COR, INC.
    Inventors: Xinshe Xu, Daniel R. Draney, Mark Cradduck, Lael Cheung, Kousik Kundu, William M. Volcheck
  • Publication number: 20150141656
    Abstract: Methods of producing OLED materials containing fluorene ring systems in which two alkyl substituents at the 9-position of fluorene ring are alkyl substituted through key intermediates generically represented by the formula: where X represents a substituent that increases the acidity of the hydrogen atoms on the adjoining methylene group (which is immediately adjacent the fluorene ring systems 9-position).
    Type: Application
    Filed: May 9, 2013
    Publication date: May 21, 2015
    Inventor: Gene Carl Koch
  • Publication number: 20150105560
    Abstract: The invention relates to formulations comprising ionic organic compounds for use in electron transport layers or electron collecting layers of organic electronic (OE) devices, more specifically in organic photovoltaic (OPV) devices, to electron transport layers comprising or being made through the use of such formulations, and to OE and OPV devices comprising such formulations or electron transport layers.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 16, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Stephane Berny, Amy Phillips, Priti Tiwana, Toby Cull, Miguel Carrasco-Orozco, Nicolas Blouin
  • Publication number: 20150044143
    Abstract: The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Application
    Filed: October 23, 2014
    Publication date: February 12, 2015
    Applicant: PHANOS TECHNOLOGIES, INC.
    Inventor: Brian D. Gray
  • Publication number: 20150031686
    Abstract: Disclosed are phenyl-oxazolyl derivatives having a general formula (I), a preparation method thereof, and an application of the phenyl-oxazolyl derivatives as an inosine monophosphate dehydrogenase (IMPDH) inhibitor.
    Type: Application
    Filed: March 6, 2013
    Publication date: January 29, 2015
    Inventors: Zhaojin Zhong, Zhuorong Li, Dajun Zhang, Yuhuan Li, Zhen Wang, Rongmei Gao, Jiajia Shen
  • Patent number: 8933190
    Abstract: Disclosed is a process for preparing a polyester or copolymer containing ester functionalities. The process can comprise: providing an optionally substituted lactone having a ring size of from 6 to 40 carbon atoms; and subjecting said lactone to metal mediated ring-opening polymerization using as catalyst a compound according to general formula (I): wherein M can be Al, Cr, Mn and Co; X and X? are independently a heteroatom; Y and Y? can be, independently, selected from O, N, S, P, C, Si, and B; Z can be selected from hydrogen, borohydrides, aluminum hydrides, carbyls, silyls, hydroxide, alkoxides, aryloxides, carboxylates, carbonates, carbamates, amidos, thiolates, phosphides, and halides; L1 and L2 can be independently an organic ligand linking X and Y together and linking X? and Y? together, respectively; and L3 is an optional organic ligand linking Y and Y? together.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: January 13, 2015
    Assignee: Saudi Basic Industries Corporation
    Inventors: Inge van der Meulen, Saskia Huijser, Erik Gubbels, Andreas Heise, Robert Duchateau, Cornelis Erne Koning
  • Patent number: 8920785
    Abstract: Cosmetic or dermatological preparations having an effective content of one or more thiazoles of the general formula.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: December 30, 2014
    Assignee: Beiersdorf AG
    Inventors: Ludger Kolbe, Cathrin Scherner
  • Publication number: 20140350227
    Abstract: The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is able to emit light using an LED light source. A novel coumarin derivative multi-fluorescent substance according to the present invention has an optimal emission wavelength band of 512 nm to 590 nm and thereby is effective in improving a signal intensity and stability since light emission using an LED light source is possible. In addition, higher fluorescence reactivity is exhibited compared to coumarin fluorescent substances known in the related arts since one molecule has a plurality of fluorescent substances, and the problem of the coumarin fluorescent substance possibly binding to a binding site of the antigen of the antibody is solved since fluorescence detection is possible even when a minimum number of fluorescent substance molecules bind to an antibody.
    Type: Application
    Filed: March 5, 2012
    Publication date: November 27, 2014
    Applicants: ACCOBIOTECH SDN BHD., GENBODY INC.
    Inventors: Hyun Park, Hak Sung Kim, Hyun Ok Song, Chom Kyu Chong, Sung Yeon Kim
  • Patent number: 8884029
    Abstract: A photoelectric conversion device capable of improving conversion efficiency is provided. The photoelectric conversion device includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided. The dye contains a cyanine compound that has a methine chain, an indolenine skeleton bonded with both ends of the methine chain, and anchor groups introduced to a nitrogen atom included in the indolenine skeleton. Electron injection efficiency to the metal oxide semiconductor layer is improved, and the dye is hardly exfoliated from the metal oxide semiconductor layer.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: November 11, 2014
    Assignee: Adeka Corporation
    Inventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Mitsuhiro Okada, Toru Yano, Yohei Aoyama, Yusuke Kubota
  • Patent number: 8858767
    Abstract: This invention is directed to a polyamic acid represented by the following formula (I), and an electrode having an active layer made from the polyamic acid of formula (I).
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: October 14, 2014
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Yaw-Terng Chern, Hsiao-Chien Chen, Rung-Ywan Tsai
  • Publication number: 20140235857
    Abstract: The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, Ax is an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, Ay is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group having 2 to 18 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, or the like. Ax and Ay optionally bond to each other to form a ring, and Q is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like.).
    Type: Application
    Filed: April 27, 2012
    Publication date: August 21, 2014
    Applicant: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama, Yasushi Nakano
  • Publication number: 20140227225
    Abstract: The present invention discloses thioflavine S and primuline derivatives which inhibit hepatitis C virus helicase and protease activity. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are useful as antiviral agents. The present invention further relates to pharmaceutical compositions containing the aforementioned compounds and methods of treating an HCV infection.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 14, 2014
    Applicants: UWM RESEARCH FOUNDATION, INC., UNIVERSITY OF KANSAS
    Inventors: Jeffrey Aube, Brian Scott Jonathan Blagg, Kevin John Frankowski, David Norman Frick, Kelin Li, Frank John Schoenen
  • Patent number: 8759534
    Abstract: The present invention relates to a trimethine cyanine represented by the formula (1): wherein all symbols are defined as in the specification.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: June 24, 2014
    Assignee: Orgchem Technologies, Inc.
    Inventors: Chin-Kang Sha, Cheng-Fen Yang, Hsin-Jen Lee, Ching-Jung Chang
  • Publication number: 20140142147
    Abstract: Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.
    Type: Application
    Filed: July 18, 2012
    Publication date: May 22, 2014
    Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Maged Henary, W. David Wilson
  • Publication number: 20140142266
    Abstract: The present invention relates to a polymerizable compound represented by a formula (I). The present invention provides a polymerizable compound, a polymerizable composition, a polymer, and an optically anisotropic article that are capable of obtaining an optical film having a low melting point, having excellent solubility, capable of being manufactured at low cost, and capable of uniform polarized light conversion across a broad wavelength region. [In formula: Y1 to Y6 are independently a chemical single bond, —O—, —O—C(?O)—, —C(?O)—O— etc.; G1 and G2 are independently a divalent C1-C20 aliphatic group etc.; Z1 and Z2 are independently C2-C10 alkenyl group that is substituted with a halogen atom etc.; Ax is a C2-C30 organic group that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring; Ay is a hydrogen atom, a C1-C20 alkyl group, a C2-C20 alkenyl group, a C3-C12 cycloalkyl group etc.; A1 is a trivalent aromatic group etc.
    Type: Application
    Filed: April 27, 2012
    Publication date: May 22, 2014
    Applicant: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama
  • Publication number: 20140061620
    Abstract: This disclosure relates to compounds for use in light-emitting devices are described herein. These compounds may include a biphenyl that includes four substituents, such as benzoxazolyl, benzothiazolyl, or benzimidazolyl substituents, such as a compound represented by Formula 1. These compounds can incorporated into a nanostructure material or a plurality of nanostructures, which can be useful for light-scattering or light-extraction, for example, to increase the efficiency of light-emitting devices.
    Type: Application
    Filed: August 27, 2013
    Publication date: March 6, 2014
    Applicant: NITTO DENKO CORPORATION
    Inventor: David T. Sisk
  • Patent number: 8604204
    Abstract: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: December 10, 2013
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Praveen Pande, Zaiguo Li, Maciej Szczepanik, Wayne Forrest Patton
  • Patent number: 8586743
    Abstract: The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: November 19, 2013
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Aleksey Rukavishnikov, Diane M. Witczak
  • Publication number: 20130270112
    Abstract: This invention is directed to a polyamic acid represented by the following formula (I), and an electrode having an active layer made from the polyamic acid of formula (I).
    Type: Application
    Filed: April 12, 2012
    Publication date: October 17, 2013
    Applicant: Chang Gun University
    Inventors: Mu-Yi Hua, Yaw-Terng Chern, Hsiao-Chien Chen, Rung-Ywan Tsai
  • Publication number: 20130252842
    Abstract: Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.
    Type: Application
    Filed: May 24, 2013
    Publication date: September 26, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jason DALLWIG, David Hagen, Ching-Ying Cheung, Gerald Thomas, Stephen Yue
  • Patent number: 8541596
    Abstract: Novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: September 24, 2013
    Assignee: Probiodrug AG
    Inventors: Ulrich Heiser, Daniel Ramsbeck, Torsten Hoffmann, Livia Boehme
  • Publication number: 20130230460
    Abstract: Radiolabeled compounds useful as diagnostic imaging agents of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
    Type: Application
    Filed: November 15, 2011
    Publication date: September 5, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Clare Jones, James Nairne
  • Patent number: 8524894
    Abstract: The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: September 3, 2013
    Assignee: Laboratorios Salvat, S.A.
    Inventors: Juan Lorenzo Catena Ruiz, Carme Serra Comas, Oscar Rey Puiggros, Albert Antolin Hernandez, Esther Monlleo Mas
  • Publication number: 20130217059
    Abstract: The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
    Type: Application
    Filed: January 3, 2013
    Publication date: August 22, 2013
    Applicant: ENZO LIFE SCIENCES, INC.
    Inventor: ENZO LIFE SCIENCES, INC.
  • Publication number: 20130209357
    Abstract: A molecular probe for use in the detection of myelin in a subject includes a compound having the general formula selected from the group consisting of: formula (I), and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 30, 2011
    Publication date: August 15, 2013
    Applicant: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Yanming Wang, Changning Wang
  • Patent number: 8471036
    Abstract: A rhodacyanine derivative represented by the following General Formula (1), wherein, in General Formula (1), R1, R2, and R3 each independently represent an alkyl group which may be substituted; Y1 and Y2 each independently represent a hydrogen atom, a chlorine atom, or a fluorine atom provided that Y1 and Y2 do not represent hydrogen atoms at the same time; and X represents a counter anion. A pharmaceutical composition for treating leishmaniasis including the rhodacyanine derivative and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: June 25, 2013
    Assignees: FUJIFILM Corporation, Hoshi University
    Inventors: Masataka Ihara, Isamu Itoh
  • Patent number: 8378120
    Abstract: Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: February 19, 2013
    Assignee: GE Healthcare UK Limited
    Inventors: Richard Martin West, Rahman Aziz Ismail
  • Publication number: 20130039870
    Abstract: Cosmetic or dermatological preparations having an effective content of one or more thiazoles of the general formula
    Type: Application
    Filed: February 21, 2011
    Publication date: February 14, 2013
    Applicant: Beiersdorf AG
    Inventors: Ludger Kolbe, Cathrin Scherner
  • Publication number: 20130005963
    Abstract: An organic photoelectric conversion material for use in an organic thin-film photoelectric conversion device, containing a compound represented by formula 1; and an organic thin-film photoelectric conversion device having a photoelectric conversion layer which containing the organic photoelectric conversion material: wherein D represents an electron-donating aromatic substituent whose bonding site atom is a sp2 carbon atom; and a plurality of D may be the same or different from each other.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 3, 2013
    Applicant: FUJIFILM CORPORATION
    Inventor: Tetsu KITAMURA
  • Publication number: 20120220639
    Abstract: A rhodacyanine derivative represented by the following General Formula (1), wherein, in General Formula (1), R1, R2, and R3 each independently represent an alkyl group which may be substituted; Y1 and Y2 each independently represent a hydrogen atom, a chlorine atom, or a fluorine atom provided that Y1 and Y2 do not represent hydrogen atoms at the same time; and X represents a counter anion. A pharmaceutical composition for treating leishmaniasis including the rhodacyanine derivative and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: October 6, 2010
    Publication date: August 30, 2012
    Applicants: HOSHI UNIVERSITY, FUJIFILM CORPORATION
    Inventors: Masataka Ihara, Isamu Itoh
  • Patent number: 8193224
    Abstract: The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: June 5, 2012
    Assignees: Fujifilm Corporation
    Inventors: Masataka Ihara, Kiyosei Takasu, Khanitha Pudhom, Hiroshi Kitaguchi, Masayuki Kawakami, Kozo Sato
  • Patent number: 8168327
    Abstract: An imide derivative represented by the following formula (A): wherein Ra and Rb are each a hydrogen atom, a halogen atom, a cyano group, an alkyl group, a fluoroalkyl group or an aryl group; at least one of Ra and Rb is a fluoroalkyl group; and Rc and Rd are each a substituted or unsubstituted benzyl group, an aryl group, a heterocycle, a fluoroalkyl group or an imide group.
    Type: Grant
    Filed: January 4, 2007
    Date of Patent: May 1, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Hironobu Morishita, Hisayuki Kawamura, Chishio Hosokawa
  • Publication number: 20120095235
    Abstract: This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.
    Type: Application
    Filed: December 2, 2011
    Publication date: April 19, 2012
    Inventors: William E. KLUNK, Chester A. Mathis, JR., Yanming Wang
  • Publication number: 20120041207
    Abstract: A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.
    Type: Application
    Filed: August 10, 2011
    Publication date: February 16, 2012
    Applicant: Sterix Limited
    Inventors: Nigel Vicker, Su Xiangdong, Dharshini Ganeshapillai, Atul Purohit, Michael John Reed, Barry Victor Lloyd Potter
  • Publication number: 20120035187
    Abstract: The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: wherein in General formula 1, R1 through R3 independently represent a hydrogen atom or an appropriate substituent; Z1 represents a heterocyclic ring and Z2 represents the same or different heterocyclic or aromatic ring as in Z1, wherein the heterocyclic and aromatic rings optionally have a substituent; represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R1 and R2 do not exist when o is 0, while, when p is 0, R3 does not exist and the binding between the carbon atom to which R2 binds and Z2 is a single bond; X1? represents an appropriate counter anion and q represents an integer of 1 or 2.
    Type: Application
    Filed: January 25, 2010
    Publication date: February 9, 2012
    Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO
    Inventors: Hitomi Ohta, Kenji Akita, Tsunetaka Ohta, Toshio Kawata, Shigeharu Fukuda
  • Publication number: 20120015992
    Abstract: Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
    Type: Application
    Filed: September 21, 2011
    Publication date: January 19, 2012
    Applicant: Burnham Institute for Medical Research
    Inventor: Maurizio Pellecchia
  • Publication number: 20120009141
    Abstract: A compound of Formula 1: or a salt thereof, and methods for the use thereof, especially as an IAP inhibitor, as well as related compounds, compositions, and methods.
    Type: Application
    Filed: August 7, 2009
    Publication date: January 12, 2012
    Applicant: PHARMASCIENCE INC.
    Inventors: Alain Laurent, Melanie Proulx, James B. Jaquith, Irina Denissova
  • Publication number: 20120001157
    Abstract: Disclosed are an organic composition including a compound represented by Chemical Formula 1, and an organic light emitting device including the composition. In Chemical Formula 1, A1, A2, A3, A4, B1, B2, B3 and B4 are independently selected from hydrogen, a C1 to C20 alkyl group, a C1 to C20 alkenyl group, an amino group, a C1 to C20 ether group, a C1 to C20 carboxyl group, a C1 to C20 ester group, a nitro group, a cyano group, a C3 to C30 aromatic group, and a halogen-containing group, provided that at least one of A1 to A4 and at least one of B1 to B4 are a substituted or unsubstituted aromatic group and form a fused ring structure by being bound to an adjacent substituent, M is a divalent or trivalent metal, X is oxygen (O) or sulfur (S), and y is 2 or 3.
    Type: Application
    Filed: June 20, 2011
    Publication date: January 5, 2012
    Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.
    Inventors: Yuji HAMADA, Kwan-Hee LEE
  • Publication number: 20110312996
    Abstract: The embodiments provide compounds of the general Formulae VI, VII, VIII, IX, X, XI, XII, XIII, XIV, and XV as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
    Type: Application
    Filed: May 16, 2011
    Publication date: December 22, 2011
    Applicant: InterMune, Inc.
    Inventors: Brad Buckman, John B. Nicholas, Vladimir Serebryany, Scott D. Seiwert
  • Patent number: 8076379
    Abstract: The present invention relates to a novel proton-conducting polymer membrane based on aromatic polyazoles which contain sulfonic acid groups and in which the sulfonic acid groups are covalently bound to the aromatic ring of the polymer and which can, owing to their excellent chemical and thermal properties, be used for a variety of purposes. Such materials are particularly useful for the production of polymer electrolyte membranes (PEMs) in PEM fuel cells.
    Type: Grant
    Filed: June 14, 2003
    Date of Patent: December 13, 2011
    Assignee: BASF Fuel Cell GmbH
    Inventors: Gordon Calundann, Michael J. Sansone, Oemer Uensal, Joachim Kiefer
  • Publication number: 20110262388
    Abstract: Novel heterocyclic derivatives as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
    Type: Application
    Filed: April 21, 2011
    Publication date: October 27, 2011
    Applicant: PROBIODRUG AG
    Inventors: Ulrich Heiser, Daniel Ramsbeck, Torsten Hoffmann, Livia Boehme
  • Publication number: 20110236310
    Abstract: The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as exposure of an ocular tissue or injection of a staining agent into the ocular tissue or a nerve tissue linking to the ocular tissue, a method of noninvasively labeling an intraocular tissue of a living individual, and a screening method using the labeling composition for the intraocular tissues. The composition contains a compound capable of labeling at least a photoreceptor cell layer of a retina, wherein the compound is a staining compound having a particular structure as a partial structure thereof.
    Type: Application
    Filed: December 24, 2009
    Publication date: September 29, 2011
    Applicant: Canon Kabushiki Kaisha
    Inventors: Kohei Watanabe, Taichi Shintou, Tsuyoshi Nomoto, Takeshi Miyazaki, Toshio Tanaka, Yuhei Nishimura, Yasuhito Shimada, Norihiro Nishimura
  • Patent number: 8017637
    Abstract: A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: September 13, 2011
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Marie-Odile Galcera-Contour, Dennis Bigg, Grégoire Prevost, Alban Sidhu
  • Publication number: 20110202942
    Abstract: An aspect of the present invention relates to an optical information recording medium comprising a recording layer, wherein the recording layer comprises a cationic dye and a polynuclear azo metal complex dye comprising an azo dye and a metal ion, and a method of recording information comprising recording information on the recording layer comprised in the optical recording medium, and conducting the recording by irradiation of a laser beam having a wavelength of equal to or shorter than 440 nm onto the optical information recording medium. Another aspect of the present invention relates to a photo sensitizer.
    Type: Application
    Filed: October 9, 2009
    Publication date: August 18, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Taisuke Fujimoto, Kousuke Watanabe, Taro Hashizume
  • Publication number: 20110196158
    Abstract: A compound represented by a Formula 1: wherein Ph1, Ar1, Ar2, Ar3 Bz1, Bz2, and Bz3 are described herein. Light-emitting devices containing the compound of Formula are also described herein.
    Type: Application
    Filed: February 3, 2011
    Publication date: August 11, 2011
    Inventor: Shijun Zheng
  • Publication number: 20110155249
    Abstract: A photoelectric conversion device capable of improving conversion efficiency is provided. The photoelectric conversion device includes a work electrode, an opposed electrode, and an electrolyte-containing layer. In the work electrode, a metal oxide semiconductor layer supporting a dye is provided. The dye contains a cyanine compound that has a methine chain, an indolenine skeleton bonded with both ends of the methine chain, and anchor groups introduced to a nitrogen atom included in the indolenine skeleton. Electron injection efficiency to the metal oxide semiconductor layer is improved, and the dye is hardly exfoliated from the metal oxide semiconductor layer.
    Type: Application
    Filed: September 9, 2009
    Publication date: June 30, 2011
    Applicants: TDK CORPORATION, ADEKA CORPORATION
    Inventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Mitsuhiro Okada, Toru Yano, Yohei Aoyama, Yusuke Kubota