Chalcogen Bonded Directly To Ring Carbon Of The Thiazole Ring Patents (Class 548/157)
  • Publication number: 20150118677
    Abstract: Described herein are methods and reagents for identifying and analyzing at least one microorganism (e.g. bacteria) in a sample and reducing the background signal intensity obtained when analyzing the sample by flow cytometry. The sample is prepared by combining the sample with a background signal-reducing molecule or with a nucleic acid stain covalently linked to a quencher. A portion of the particulate matter in the sample can optionally be removed with a resin prior to staining with a nucleic acid stain.
    Type: Application
    Filed: April 4, 2013
    Publication date: April 30, 2015
    Applicant: BECTON, DICKINSON AND COMPANY
    Inventors: Xiao Li, Yongqiang Zhang, Kenneth Anthony Kopher, John D. Mantlo, William Alfred Pope, Song Shi, Axel A. Yup
  • Patent number: 8586743
    Abstract: The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: November 19, 2013
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Aleksey Rukavishnikov, Diane M. Witczak
  • Publication number: 20130005982
    Abstract: The present invention provides a diaryl sulfone compound represented by Formula (1): wherein R1 to R4 and R1? to R4? are the same or different, and each represents hydrogen, C1-4 alkyl, or halogen, and R5 represents C2-6 alkenyl, C1-4 alkyl, or aromatic heterocyclic group; a method for producing the diaryl sulfone compound represented by Formula (1) by reacting a 4,4?-dihaloarylsulfone compound with thiol salt compound having an alkylene group; and a method for producing the diaryl sulfone compound represented by Formula (1) by reacting a 4,4?-dihaloarylsulfone compound with a thiol salt compound having a hydroxyl group, and subjecting the resulting compound to reaction with a halogenating agent, followed by a dehydrohalogenation reaction.
    Type: Application
    Filed: March 9, 2011
    Publication date: January 3, 2013
    Applicant: SUMITOMO SEIKA CHEMICALS CO., LTD.
    Inventors: Paul Kuad, Hisaaki Kanda, Takeshi Fujiwara, Hiroyuki Shiraishi
  • Publication number: 20110170209
    Abstract: Compounds of the formula I or (I?), wherein R1 and R?1 for example are hydrogen, C3-C8cycloalkyl or C1-C12alkyl, R2 and R2? for example are hydrogen; unsubstituted C1-C20alkyl or substituted C1-C20alkyl; and R8 and R9 for example are hydrogen, C1-C12alkyl which optionally is substituted, or phenyl which optionally is substituted; exhibit an unexpectedly good performance in photopolymerization reactions.
    Type: Application
    Filed: May 27, 2009
    Publication date: July 14, 2011
    Applicant: BASF SE
    Inventors: Akira Matsumoto, Hisatoshi Kura
  • Publication number: 20090264459
    Abstract: Compounds of formula (I) in free or a pharmaceutically acceptable salt form, wherein X1, L and Q have the meanings as indicated in the specification, are useful for treating obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Application
    Filed: June 28, 2007
    Publication date: October 22, 2009
    Inventors: Stephen Paul Collingwood, Robin Alec Fairhurst, Neil John Press
  • Publication number: 20090061143
    Abstract: A recording layer including a novel organic compound for a high density optical recording medium is provided. The information may be recorded on the recording layer at a 2× speed or higher speed with a relatively lower writing power so that heat distribution of the recording layer in the irradiated area is not likely to become steep both in time and space. The organic compound incorporated in the recording layer has the following general chemical structural formula (I).
    Type: Application
    Filed: September 5, 2007
    Publication date: March 5, 2009
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ming-Chia Li, An-Tse Lee, Chien-Liang Huang, Chung-Ta Cheng, Kuo-Chi Chiu, Tzuan-Ren Jeng
  • Patent number: 6908726
    Abstract: Infrared absorbing compounds that absorb at 800 nm±50 nm and at 1050 nm±50 nm, the two different regions of the infrared spectrum typically used for imaging, are disclosed. Thermally imageable elements that comprise these infrared absorbing compounds can be imaged with radiation in either of these two regions of the infrared spectrum. The elements are especially useful as lithographic printing plate precursors.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: June 21, 2005
    Assignee: Kodak Polychrome Graphics LLC
    Inventors: Lee Korionoff, Ting Tao, Kevin B. Ray
  • Patent number: 6869913
    Abstract: Novel pyridazin-3-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R1 is haloalkyl; R2 and R3 are hydrogen, alkyl, haloalkyl, or alkoxyalkyl; and Q is [Q-1], [Q-2], [Q-3], [Q-4] or [Q-5]. Also provided are their use and intermediates for their production.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: March 22, 2005
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tadashi Katayama, Shinichi Kawamura, Yuzuru Sanemitsu, Yoko Mine
  • Publication number: 20040210062
    Abstract: The solution concerns a process of production of N-alkyl-2-benzthiazolylsulfeneimides by means of a reaction of 2-benzthiazolylsulfenyl chloride with an excess of a corresponding alkylamine in an anhydrous reaction medium. Removement of water and moisture from the reaction medium is ensured by azeotropic distillation of a part of the solvent. The method solves also trapping of the excess amine by extraction with water to recycle it in the process, removing of the unconverted raw material from the crude product by chemical refining with aqueous lye and extraction of by-products and pitches by elutriating the product in an organic solvent with the aim to obtain pure benzthiazolylsulfeneimide containing no less than 95% of the active substance, which can be used as a vulcanization accelerator in ruber mixtures.
    Type: Application
    Filed: March 15, 2004
    Publication date: October 21, 2004
    Inventors: Karol Krizanovic, Gabriel Sereda, Alzbetta Strauchove, Jozef Pinter, Kamil Vali
  • Publication number: 20040197697
    Abstract: Infrared absorbing compounds that absorb at 800 nm±50 nm and at 1050 nm±50 nm, the two different regions of the infrared spectrum typically used for imaging, are disclosed. Thermally imageable elements that comprise these infrared absorbing compounds can be imaged with radiation in either of these two regions of the infrared spectrum. The elements are especially useful as lithographic printing plate precursors.
    Type: Application
    Filed: April 7, 2003
    Publication date: October 7, 2004
    Inventors: Lee Korionoff, Ting Tao, Kevin B. Ray
  • Publication number: 20040063755
    Abstract: The invention provides novel &bgr;2 adrenergic receptor agonist compounds of formula (I): 1
    Type: Application
    Filed: August 18, 2003
    Publication date: April 1, 2004
    Inventors: Edmund J. Moran, John R. Jacobsen, Michael R. Leadbetter, Matthew B. Nodwell, Sean G. Trapp, James Aggen, Timothy J. Church
  • Publication number: 20040063584
    Abstract: Cyclohexenone derivatives of benzazolones of the formula I 1
    Type: Application
    Filed: May 29, 2003
    Publication date: April 1, 2004
    Inventors: Guido Mayer, Ulf Miblitz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Michel Hofmann, Thorsten Volk, Matthias Witschel, Cyrill Zagar, Andreas Landes, Klaus Langemann
  • Publication number: 20040023999
    Abstract: Compounds of Formula (IA) and Formula (IB) 1
    Type: Application
    Filed: March 21, 2003
    Publication date: February 5, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Younes Bekkali, Rajashehar Betageri, Mario G. Cardozo, Thomas A. Gilmore, Christian Hanke Justus Joachim Harcken, Thomas M. Kirrane, Daniel Kuzmich, John Robert Proudfoot, Doris Riether, Hidenori Takahashi, David S. Thomson, Ji Wang, Renee Zindell, Hossein Razavi
  • Publication number: 20040009995
    Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Nalin Subasinghe, Ehab Khalil, Kristi Leonard, Farah Ali, Heather Rae Hufnagel, Jeremy M. Travins, Shelley K. Ballentine, Kenneth T. Wilson, Maxwell D. Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen, M. Jonathan Rudolph, Hui Huang
  • Publication number: 20030180221
    Abstract: A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.
    Type: Application
    Filed: December 20, 2002
    Publication date: September 25, 2003
    Applicant: Schering AG
    Inventors: Naoto Miwa, Michihito Inagaki, Hiroaki Eguchi, Masafumi Okumura, Yoshio Inagaki, Toru Harada
  • Publication number: 20020169185
    Abstract: Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPAR&ggr;. In particular, the compounds of the invention modulate the function of PPAR&ggr;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
    Type: Application
    Filed: June 27, 2001
    Publication date: November 14, 2002
    Inventors: Lawrence R. McGee, Jonathan B. Houze, Steven M. Rubenstein, Atsushi Hagiwara, Noboru Furukawa, Hisashi Shinkai
  • Publication number: 20020099074
    Abstract: The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same.
    Type: Application
    Filed: December 19, 2001
    Publication date: July 25, 2002
    Applicant: Kowa Company, Ltd.,Japan
    Inventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toshiyuki Edano, Mitsuteru Hirata, Chiyoka Ozaki
  • Publication number: 20010039351
    Abstract: The invention relates to a process for preparing benzothiazolone compounds having pharmacological activity and to intermediates used in their preparation.
    Type: Application
    Filed: April 27, 2001
    Publication date: November 8, 2001
    Applicant: AstraZeneca AB
    Inventor: Stephen Ch. Eyley
  • Patent number: 6281238
    Abstract: This invention provides compounds of Formula I having the structure wherein B and D are each, independently, hydrogen, halogen, —CN, alkyl of 1-6 carbon atoms, aryl, or aralkyl of 6-12 carbon atoms; R1 is hydrogen, alkyl of 1-6 carbon atoms, —CH(R2)W, —C(CH3)2CO2R3, 5-thiazolidine-2,4-dione, —CH(R4)CH2CO2R3, —COR3, or —PO3(R3)2; R2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, aryl, —CH2(1H-imidazol-4-yl), —CH2(3-1H-indolyl), —CH2CH2(1,3-dioxo-1,3-dihydro-isoindol-2-yl), —CH2CH2(1-oxo-1,3-dihydro-isoindol-2-yl), or —CH2(3-pyridyl); W is —CO2R3, —CONH2, —CONHOH, —CN, CONH(CH2)2CN, 5-tetrazole, or —PO3(R3)2; R3 is hydrogen, alkyl of 1-6 carbon atoms, or aryl; R4 is hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: August 28, 2001
    Assignee: American Home Products Corporation
    Inventors: Jay E. Wrobel, Zenan Li
  • Patent number: 6225331
    Abstract: This invention involves compounds having the following structure: as described in the claims; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: May 1, 2001
    Assignee: The Procter & Gamble Company
    Inventors: Thomas Lee Cupps, Sophie Eva Bogdan, Raymond Todd Henry, Russell James Sheldon, William Lee Seibel, Jeffrey Joseph Ares
  • Patent number: 6184385
    Abstract: A process for the manufacture of a sulfenimide by reacting sulfenamide in slurry with a water immiscible organic solvent with an acid to yield a solvent slurry comprising sulfenimide product. The product is recovered from the solvent slurry by a method comprising the addition of water to the solvent slurry and the isolating of the product by a single filtration step. While water is added to the solvent slurry an azeotrope of solvent and water may be distilled under vacuum until substantially all solvent is separated from product and product becomes part of an aqueous slurry. Alternatively, water may be added to the solvent slurry while the resulting mixture is being agitated, followed by filtering the mixture in the single filtration step for recovery of product from the mixture.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: February 6, 2001
    Assignee: Flexsys America L.P.
    Inventors: Jayant S. Lodaya, Donald L. Fields, Jr., Raymond T. Parker, Phillip B. Balderson
  • Patent number: 6180795
    Abstract: There is disclosed a process for the preparation of sulfenimides comprising: mixing, in a hydrocarbon solvent, a sulfenamide of the formula with an aldehyde of the formula R4CHO where X is a sulfur atom, a —C═N— group, or a —C═C— group, R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and aryl or may be joined to form a saturated or unsaturated ring or aromatic ring, R3 is alkyl or cycloalkyl, and R4 is a hydrocarbon radical wherein the carbon bearing the aldehyde function is bonded only to other carbon atoms, a substituted or unsubstituted aryl ring, or a heteroaromatic ring; and heating the mixture at a temperature and for a period of time sufficient to convert the sulfenamide to the sulfenimide.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: January 30, 2001
    Assignee: Uniroyal Chemical Company, Inc.
    Inventors: Joseph F. Stieber, Franklin H. Barrows
  • Patent number: 6139782
    Abstract: Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon-carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group.Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: October 31, 2000
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva
  • Patent number: 6045991
    Abstract: Compounds which generate red chemiluminescence on reaction with a phosphatase enzyme are provided as well as intermediates useful for their preparation. The chemiluminescent compounds comprise a luciferin ring system and an exocyclic enol phosphate group where the position on the luciferin ring system adjacent to the double bond is disubstituted. The chemiluminescent compounds are useful alone or within compositions containing a cationic aromatic compound in methods for producing chemiluminescence. The chemiluminescent reactions can be applied in assays for phosphatase enzymes and in assays employing enzyme-labeled specific binding pairs.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: April 4, 2000
    Assignee: Lumigen, Inc.
    Inventor: Hashem Akhavan-Tafti
  • Patent number: 5942547
    Abstract: This invention provides a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.3 independently are hydrogen, --CHO, --COCH.sub.3, --COR.sup.7, --A--Ar--(Q).sub.z, etc.; wherein D is a C.sub.1-6 linear, C.sub.3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc.; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH.sub.2, --NHR.sub.7, etc.; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO.sub.2 W, --SOW, etc.; wherein Y is hydrogen, alkyl, alkenyl, --B--NH.sub.2, --B--NHR.sup.8, etc.; wherein W is alkyl, alkenyl, --B--NH.sub.2, etc.; wherein A nd B independently are a bond, or a C.sub.1-6 linear, C.sub.3-8 branched or cyclic linking group having from 1 to about 15 atoms, consisting of C, optionally interrupted by N, S, P and O; wherein A and B independently are unsubstituted or substituted with --OH, NH.sub.2, etc.; wherein R.sup.7 is an alkyl, a branched alkyl, etc.; wherein R.sup.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: August 24, 1999
    Assignee: Scriptgen Pharmaceuticals, Inc.
    Inventors: Gary R. Gustafson, David G. Powers, Mark A. Wuonola
  • Patent number: 5716756
    Abstract: Sulfonic acid esters are used as (a) compounds for forming a strong acid on irradiation in radiation-sensitive, positive or negative working mixtures also comprising (b) either a compound with at least one acid-decomposable C--O--C or C--O--Si bond (for positive working mixtures) or a compound with at least acid-cross-linkable groups (for negative working mixtures) and c) a binder which is insoluble in water but soluble or at least swellable in aqueous alkaline solutions, wherein said sulfonic acid esters are formula?R.sup.1 --CR.sup.2 (CF.sub.3)--O--SO.sub.2 --!.sub.n R.sup.3(I)orR.sup.1 ?--CR.sup.2 (CF.sub.3)--O--SO.sub.2 --R.sup.3 !m (II)wherein R.sup.1, R.sup.2, R.sup.3, n and n are defined with the body of the disclosure. These mixtures are particularly suitable for exposure to deep UV radiation in the formation of recording materials suitable for the production of photoresists, electronic components, and printing plates.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: February 10, 1998
    Assignees: Hoechst Aktiengesellschaft, Herberts GmbH
    Inventors: Georg Pawlowski, Walter Spiess, Horst Roeschert, Wolfgang Appel, Walter Herr
  • Patent number: 5424442
    Abstract: A water-soluble methine compound represented by the following general formula (I): ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents a non-metallic atomic group required for forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring; R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl group; Q.sub.1 and Q.sub.2 each represents an atomic group required, in combination, for forming a 4-thiazolidinone ring, a 5-thiazolidinone ring, a 4-imidazolidinone ring, a 4-oxazolidinone ring, a 5-oxazolidinone ring, a 5-imidazolidinone ring or a 4-dithiolanone ring; L.sub.1, L.sub.2, L.sub.3, L.sub.4 and L.sub.5, which may be the same or different, each represents a methine group; R represents a hydrogen atom, an alkyl group, an aryl group or a heterocyclic group; m represents 1 or 2; i and h each represents 0 or 1; l represents 1 or 2; and j and k each represents 0, 1, 2 or 3.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: June 13, 1995
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Keizo Koya, Toshinao Ukai, Haruo Takei
  • Patent number: 5395854
    Abstract: Ortho-substituted phenyl-acetamides I ##STR1## (R.sup.1 =H, alkyl, cycloalkyl, alkenyl, alkynyl, phenylalkynyl, alkoxyalkyl, alkoxycarbonyl, phenyl, phenylalkyl, phenylalkenyl or phenoxyalkyl, 5- or 6-membered heterocycle with 1-3 hetero atoms to which a benzene ring or a 5- or 6-membered heterocycle can be fused; R.sup.2 and R.sup.3 =H, CN, halogen, alkyl, alkoxy; R.sub.4 and R.sup.5 =H, alkyl and R.sup.4 or R.sup.5 =alkoxy; Y=O, S, SO, SO.sub.2, N=N, O--CO, CO--O, CO--O--CH.sub.2, alkylene or haloalkylene, alkenylene, alkynylene, oxy- alkylene, thio-alkylene, alkyleneoxy, carbonylalkylene or alkylenecarbonyl, W=alkoxyimino, alkoxymethylene or alkylthiomethylene), excepting compounds where R.sup.1 is hydrogen, phenyl or 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropyl, R.sup.2 to R.sup.5 are each hydrogen, Y is carbonyloxymethylene and W is methoxymethylene or methylthiomethylene, are suitable as fungicides and for controlling pests.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: March 7, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Siegbert Brand, Eberhard Ammermann, Gisela Lorenz, Hubert Sauter, Klaus Oberdorf, Uwe Kardorff, Christoph Kuenast
  • Patent number: 5371222
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: December 6, 1994
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5371223
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: December 6, 1994
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5349001
    Abstract: Water-soluble cyclic imide thione activated polyalkylene oxides having improved hydrolytic stability are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active nucleophiles are also disclosed.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: September 20, 1994
    Assignee: Enzon, Inc.
    Inventors: Richard B. Greenwald, Anthony J. Martinez
  • Patent number: 5286870
    Abstract: Bis-benzthiazolyl alkyl sulfenimides are produced by a process in which alkyl amines are reacted with optionally substituted 2-mercaptobenzthiazoles in the presence of oxygen or oxygen-containing gases and copper and/or copper compounds and in the presence of inert organic solvents.
    Type: Grant
    Filed: August 17, 1992
    Date of Patent: February 15, 1994
    Assignee: Bayer AG
    Inventors: Adolf Sicheneder, Harro Schlesmann
  • Patent number: 5204481
    Abstract: An improved process for producing N-alkyl or N-cycloalkyl-2-benzothiazole sulfenimides uses aliphatic hydrocarbons as a reaction medium in converting N-alkyl or N-cycloalkyl-2-benzothiazole sulfenamides to the corresponding sulfenimides by reaction with an acid.
    Type: Grant
    Filed: June 8, 1992
    Date of Patent: April 20, 1993
    Assignee: Monsanto Company
    Inventors: Sharen B. Carroll, Horng-Jau Lin, Roger K. Rains
  • Patent number: 5185342
    Abstract: A fungicidal composition for agricultural use, which comprises a compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen, lower alkyl or cyclo(lower)alkyl; R.sup.3 is lower alkyl or cyclo(lower)alkyl; R.sup.4 and R.sup.5 are each hydrogen, lower alkyl, lower alkoxy, halogen-substituted lower alkyl, lower alkyl-substituted silyl, halogen or nitro; A represents an unsaturated hydrocarbon group, a halogen-substituted unsaturated hydrocarbon group, a phenyl group or a heterocyclic group, among which the phenyl group and the heterocyclic group may be optionally substituted with not more than three substituents; and Z is --CH.sub.2 --, --CH(OH)--, --CO--, --O--, --S--, --NR-- (R being hydrogen or lower alkyl), --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --OCH.sub.2 --, --SCH.sub.2 -- or --SOCH.sub.2 --.
    Type: Grant
    Filed: May 16, 1990
    Date of Patent: February 9, 1993
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Yoshio Hayase, Takahiro Kataoka, Hideyuki Takenaka, Mitsuhiro Ichinari, Michio Masuko, Toshio Takahashi, Norihiko Tanimoto
  • Patent number: 5169950
    Abstract: Compounds of the formula I ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, and R.sup.5 have the meaning given in claim 1 are formed by thermal rearrangement of the isomers of formula V ##STR2## especially in the presence of basic catalysts. The compounds are corrosion inhibitors for organic materials, in particular coating materials and lubricants. In these substrates they also act as antioxidants and light-stabilizers and are very stable to heat.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: December 8, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Adalbert Braig, Hans-Rudolf Meier, David G. Leppard, Robert C. Wasson, Emyr Phillips
  • Patent number: 5110941
    Abstract: A method of producing 1H-pyrazolo[5,1-c]-1,2,4-triazoles represented by general formula (II): ##STR1## (wherein R.sub.1, R.sub.2 and R.sub.3 each represents a hydrogen atom or a substituent group) which comprises making a compound represented by general formula (I) undergo a ring closure reaction: ##STR2## (wherein R.sub.1, R.sub.2 and R.sub.3 each represents a hydrogen atom, or a substituent group), and a method of producing a pyrazol derivative represented by general formula (I) by reacting a compound represented by general formula (III) and general formula (IV): ##STR3## wherein R.sub.1, R.sub.2 and R.sub.3 have the same meaning as in general formula (I); Y represents an acid radical; and n represents 0 to 1.
    Type: Grant
    Filed: October 19, 1989
    Date of Patent: May 5, 1992
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Masato Taniguchi, Tadahisa Sato
  • Patent number: 5103007
    Abstract: Lipid derivatives represented by the formula: ##STR1## wherein R.sup.1 stands for an optionally substituted higher alkyl group, R.sup.2 stands for an optionally substituted lower alkyl group or an optionally substituted nitrogen-containing heterocyclic group, R.sup.3 stands for a tertiary amino group or a quaternary ammonium group, J stands for oxygen atom or S(O)t (where t deontes 0, 1 or 2), m and n respectively denotes 1 or 2, p denotes 0, 1 or 2, q and r respectively denote an integer of 2 to 5.and salts thereof have antitumor activities including differentiation-inducing activity and are useful as antitumor agents.
    Type: Grant
    Filed: October 27, 1989
    Date of Patent: April 7, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Hiroshi Akimoto, Keizo Inoue
  • Patent number: 5081245
    Abstract: A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group;R.sup.1 represents a higher alkyl group which may be substituted;R.sup.2 represents a hydrogen atom or a lower alkyl group, a lower alkanoyl group or a nitrogen-containing 5- to 7-membered heterocyclic group each of which may be substituted; X represents a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --wherein p represents an integer of 1 to 5, a divalent group represented by the formula:--O(CH.sub.2).sub.q --wherein q represents an integer of 3 to 8, or a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --J--(CH.sub.2).sub.q --wherein J represents an oxygen atom or a group represented by the formula: --S(O).sub.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: January 14, 1992
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hiroaki Nomura, Hiroshi Akimoto, Eiko Imamiya, Keizo Inoue
  • Patent number: 5073279
    Abstract: Sulfur-coupled hydrocarbyl derived mercaptobenzothiazole adducts have been found to be effective multifunctional antiwear additives for fuels and lubricants.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: December 17, 1991
    Assignee: Mobil Oil Corporation
    Inventors: Liehpao O. Farng, Andrew G. Horodysky, James G. Murray
  • Patent number: 5055477
    Abstract: A pyrazolyl acrylic acid derivative having plant fungicidal activity of formula (I): ##STR1## wherein: R.sub.1 and R.sub.2 are independently hydrogen or C.sub.1 -C.sub.5 alkyl;A is a group of the formula: ##STR2## wherein X is independently hydrogen; halogen; cyano; nitro; C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.11 alkenyl, C.sub.1 -C.sub.10 alkoxy, C.sub.2 -C.sub.11 alkenyloxy, C.sub.2 -C.sub.11 alkynyloxy, C.sub.2 -C.sub.11 alkylcarbonyl or C.sub.2 -C.sub.11 alkylcarbonyloxy optionally substituted with one or more substituents selected from halogen, nitro, cyano, trifluoromethyl and C.sub.1 -C.sub.5 alkoxy; or C.sub.7 -C.sub.13 arylcarbonyl, C.sub.4 -C.sub.9 cycloalkylcarbonyloxy, C.sub.7 -C.sub.13 arylcarbonyloxy, C.sub.6 -C.sub.12 aryl, C.sub.6 -C.sub.12 aryloxy, C.sub.2 -C.sub.13 heteroaryl having 1-3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, C.sub.2 -C.sub.13 heteroaryloxy having 1-3 heteroatom(s) selected from oxygen, sulfur, and nitrogen, C.sub.7 -C.sub.12 aralkyl or C.sub.7 -C.sub.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: October 8, 1991
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Masatsugu Oda, Toshiro Sakaki, Kazuhiko Kikutake
  • Patent number: 5055582
    Abstract: This invention relates to a process for preparing useful thromboxane A.sub.2 inhibiting (.+-.)7-[3.alpha.-[1-[[(phenylamino)thioxomethyl]hydrazono]ethyl]-1.alpha. ,4.alpha.-bicyclo[2.2.1]hept-2.beta.-yl]-heptenoic acids and useful derivatives thereof from (.+-.)octahydro-1.alpha.-methyl-3a.alpha.,7a.alpha.-4.alpha.,7.alpha.-meth ano-2H-inden-2-ones.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: October 8, 1991
    Assignee: National Research Development Corporation
    Inventors: Robert B. Garland, Masateru Miyano
  • Patent number: 5032590
    Abstract: Substituted hydroxylamines of the formula ##STR1## in which R.sup.1 stands for an aromatic or heterocyclic radical,are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis.
    Type: Grant
    Filed: March 8, 1990
    Date of Patent: July 16, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
  • Patent number: 4968681
    Abstract: Substituted hydroxylamines of the formula ##STR1## in which R.sup.1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia and atherosclerosis.
    Type: Grant
    Filed: November 15, 1988
    Date of Patent: November 6, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt
  • Patent number: 4937255
    Abstract: For inhibiting 3-hydroxy-3-methylglutaryl coenzyme A and cholesterol biosynthesis, the novel disubstituted pyrroles of the formula ##STR1## in which R.sup.1 is aryl or heteroaryl,R.sup.2 is cycloalkyl or optionally substituted alkyl,R.sup.3 is hydrogen or cycloalkyl, or optionally substituted alkyl, aryl or heteroaryl,X is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,A is ##STR2## R.sup.6 is hydrogen or alkyl, and R.sup.7 is hydrogen, a cation or alkyl, aryl or aralkyl.
    Type: Grant
    Filed: March 16, 1989
    Date of Patent: June 26, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Hubsch, Rolf Angerbauer, Peter Fey, Hilmar Bischoff, Dieter Petzinna, Delf Schmidt, Gunter Thomas
  • Patent number: 4914206
    Abstract: The present invention provides lankacidin derivatives of the formula ##STR1## and procedures for the production thereof. The lankacidin derivatives [1] show excellent antimicrobial activities and thus can be used for prophylaxis and treatment of infectious disease in animals.
    Type: Grant
    Filed: December 15, 1988
    Date of Patent: April 3, 1990
    Assignee: Takeda Chemical Industries, LTD.
    Inventors: Isao Minamida, Naoto Hashimoto
  • Patent number: 4873346
    Abstract: The present invention provides certain novel substituted benzothiazoles, benzimidazoles and benzoxazoles which are useful as inhibitors of leukotriene biosynthesis and/or as inhibitors of the action of lipoxygenase and/or as inhibitors of mucus secretion in mammalian metabolism. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: October 10, 1989
    Assignee: The Upjohn Company
    Inventor: David J. Anderson
  • Patent number: 4746351
    Abstract: This invention relates to herbicidally active substituted benzoxazole (or benzothiazole) compounds and to the use of such compounds to control the growth of noxious plants, i.e., weeds.
    Type: Grant
    Filed: May 12, 1986
    Date of Patent: May 24, 1988
    Assignee: PPG Industries, Inc.
    Inventor: Donald R. Nielsen
  • Patent number: 4724201
    Abstract: A photoresponsive material containing a dye compound having a cyclodextrin or its derivative as a substituent. The photoresponsive material exhibits increased light absorptivity by increasing the amount of spectral sensitizer, the dye compound. The photoresponsive material is useful as a photographic emulsion and the like.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: February 9, 1988
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Masaki Okazaki, Akihiko Ikegawa, Haruo Takei
  • Patent number: 4701512
    Abstract: The adducts of isocyanates wtih benzoxazolones or benzoxazinediones are novel compounds which may be employed as blocked isocyanates and are particularly useful as latent, epoxide curing agents. At typical epoxide curing temperatures, the isocyanate is oxirane or hydroxyl reactive and the benzoxazole or benzoxazinedione acts like a di- or trifunctional phenol, respectively.
    Type: Grant
    Filed: October 29, 1985
    Date of Patent: October 20, 1987
    Assignee: The Dow Chemical Company
    Inventor: Theodore L. Parker
  • Patent number: 4591647
    Abstract: 2,2'-dibenzothiazolyl disulphide produced from an alkali metal salt of 2-mercaptobenzothiazole by oxidation using chlorine is obtained substantially free from acid by-products if oxidation is carried out under such conditions that the reaction mixture still contains at least 2.5%, by weight, of the alkali metal salt of 2-mercaptobenzothiazole at the end of the reaction.
    Type: Grant
    Filed: August 16, 1984
    Date of Patent: May 27, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventor: Alfredo Wust