Abstract: Diphenylamine-benzobisthiazole-diphenylamine monomers having two-photon absorption cross-sections and high solubility in organic solvents are provided. Also provided are the corresponding organo-soluble, wholly conjugated and two-photon absorbing benzobisthiazole-triarylamine polymers.

Abstract: The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiazolyl and indazolyl; p is an integer ranging from 0 to 5; R1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5; or corresponds to a group R5; each R2 is independently hydrogen, fluorine or C1-4alkyl; n is 2, 3, 4, or 5; R3 is C1-4alkyl; R4 is hydrogen, or a C1-4alkyl group, a benzyl group, a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5;or R4 is a —SR6 group; R5 is selected from a group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido- 2-isothi

Abstract: The solution concerns a process of production of N-alkyl-2-benzthiazolylsulfeneimides by means of a reaction of 2-benzthiazolylsulfenyl chloride with an excess of a corresponding alkylamine in an anhydrous reaction medium. Removement of water and moisture from the reaction medium is ensured by azeotropic distillation of a part of the solvent. The method solves also trapping of the excess amine by extraction with water to recycle it in the process, removing of the unconverted raw material from the crude product by chemical refining with aqueous lye and extraction of by-products and pitches by elutriating the product in an organic solvent with the aim to obtain pure benzthiazolylsulfeneimide containing no less than 95% of the active substance, which can be used as a vulcanization accelerator in ruber mixtures.

Abstract: The invention provides methods of using a compound as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and kits for performing these methods.

Abstract: The invention relates to a process for the production of 2,2′-dithiazolyl disulfides by oxidation of 2-mercaptothiazoles with peroxidic compounds in an aqueous suspension in a specific pH range.

Abstract: Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

Abstract: The invention relates to a process for the production of 2,2′-dithiazolyl disulfides by oxidation of 2-mercaptothiazoles with peroxidic compounds in an aqueous suspension in a specific pH range.

Abstract: A cyanine dye having the formula 1

Abstract: The invention relates to a new process for the preparation of dithiazolyl-(2,2′)-disulfides by oxidation of 2-mercaptothiazoles, to the dithiazolyl-(2,2′)-disulfides that can be obtained in this way, and to the use thereof.

Abstract: There is disclosed a process for the preparation of sulfenimides comprising: mixing, in a hydrocarbon solvent, a sulfenamide of the formula with an aldehyde of the formula R4CHO where X is a sulfur atom, a —C═N— group, or a —C═C— group, R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and aryl or may be joined to form a saturated or unsaturated ring or aromatic ring, R3 is alkyl or cycloalkyl, and R4 is a hydrocarbon radical wherein the carbon bearing the aldehyde function is bonded only to other carbon atoms, a substituted or unsubstituted aryl ring, or a heteroaromatic ring; and heating the mixture at a temperature and for a period of time sufficient to convert the sulfenamide to the sulfenimide.

Abstract: The invention relates to a new process for the preparation of dithiazolyl-(2,2')-disulfides by oxidation of 2-mercaptothiazoles, to the dithiazolyl-(2,2')-disulfides that can be obtained in this way, and to the use thereof.

Abstract: A method of stabilizing non-halogen containing 3-isothiazolone microbicides against chemical degradation by the introduction of aromatic disulfide compounds (except 2,2'-dithiobisbenzoic acid) is disclosed.

Abstract: The present invention is concerned with the use of certain 3-aminopyrazolo-heterocyclic compounds for the colorimetric determination of hydrogen peroxide, hydrogen peroxide-forming systems, peroxidase, peroxidate-active substances and electron-rich aromatic compounds. The present invention is also concerned with corresponding processes of determination and with agents appropriate therefor. Furthermore, the present invention is concerned with new 3-aminopyrazolo-heterocyclic compounds.

Abstract: There are provided 1H-pyrazolo[1,5-b]-1,2,4-triazole magenta couplers or 1H-pyrazolo[5,1-c]-1,2,4-triazole magenta couplers characterized by having at the 6-position a phenoxy group, on the ortho-position of which is an alkoxy group or an aryloxy group. A photographic material comprising the magenta coupler is excellent in color reproducibility and exhibits superior photographic characteristics in any of sensitivity, gradation, and color density.

Abstract: Sulfur-coupled hydrocarbyl derived mercaptobenzothiazole adducts have been found to be effective multifunctional antiwear additives for fuels and lubricants.

Abstract: An improved process for the manufacture of 2,2'-dithiobis(benzothiazole). More particularly, the invention relates to an improved process for preparing 2,2'-dithiobis(benzothiazole) using various nonionic and cationic surfactants to reduce or eliminate the formation of large particles in the product.

Abstract: An improved process for preparing certain nitrogen-containing mono- and bicyclic ACE inhibitors comprising reacting an .alpha.-alkyl amino acid with a disulfide compound to form a thioester intermediate, which intermediate is then amidated with a mono- or bicyclic amino acid. The invention also relates to the novel thioester intermediates prepared by the first step of the process.

Abstract: There is disclosed a preparation of (optionally substituted) 2,2'-dithiobis(benzothiazole) by the oxidation of 2-mercaptobenzothiazole using bromate salts as the oxidant in an acidified aqueous reaction medium. The process of this invention provides an efficient and practical step in a procedure for the production of 2,2'-dithiobis(benzothiazole) that is virtually pollution free.

Abstract: There is disclosed a preparation of (optionally substituted) 2,2'-dithiobis(benzothiazole) by the oxidation of 2-mercaptobenzothiazole using bromate salts as the oxidant in an aqueous/alcohol reaction medium. The process of this invention provides an efficient and practical step in a procedure for the production of 2,2'-dithiobis(benzothiazole) that is virtually pollution free.

Abstract: 2,2'-dibenzothiazolyl disulphide produced from an alkali metal salt of 2-mercaptobenzothiazole by oxidation using chlorine is obtained substantially free from acid by-products if oxidation is carried out under such conditions that the reaction mixture still contains at least 2.5%, by weight, of the alkali metal salt of 2-mercaptobenzothiazole at the end of the reaction.

Abstract: A process for the preparation of dithiazolyl disulfides by the catalytic oxidation of a 2-mercaptothiazole with ammonia and either oxygen or an oxygen-containing gas at a temperature of between 0.degree. and 150.degree. C.

Abstract: A continuous process for preparing benzothiazyl disulfide. More particularly, the invention relates to an improved continuous process for preparing benzothiazyl disulfide by oxidizing sodium mercaptobenzothiazole with chlorine under controlled conditions of pH, reactant concentrations, oxidation-reduction potential and agitation.

Abstract: There is disclosed an improved method of preparing dibenzothiazolyl disulfides by oxidizing mercaptobenzothiazole with hydrogen peroxide in the presence of an amine. The invention has particular utility by providing a relatively pollution free method of preparing dibenzothiazolyl disulfides.

Abstract: Disclosed is a novel process for the preparation of 2-amino-6-nitrobenzothiazole which comprises contacting 2-mercapto-6-nitrobenzothiazole with hydrogen peroxide in the presence of ammonia. The reaction is conveniently conducted in an aqueous medium. The mole ratio of hydrogen peroxide to mercaptan is preferably about 4:1 and the reaction is conducted at a temperature of about 50.degree. to 100.degree. C.

Abstract: A process for the preparation of dibenzothiazyl disulfide by oxidation of mercaptobenzothiazole in aqueous suspension by means of hydrogen peroxide, in which the oxidation is effected in the presence of ethylenediaminetetraacetic acid or an alkali metal salt derived therefrom.

Abstract: This disclosure relates to a novel process for preparing a class of dithiazolyl-(2,2')-disulfides by the catalytic oxidation of 2-mercaptothiazoles. In particular the present invention involves a process for preparing dibenzothiazyl-disulfides upon the oxidation of a 2-mercaptobenzothiazole in the presence of a tertiary amine.