The Chalcogen, X, Is In A -c(=x)- Group Patents (Class 548/261)
  • Publication number: 20090088361
    Abstract: The present invention provides a cleaning agent for cleaning a semiconductor device having copper wiring on the surface thereof following a chemical mechanical polishing process in a production process of a semiconductor device, including a compound represented by the following formula (I): X1-L—X2??formula (I) wherein, in formula (I), X1 and X2 each independently represent a monovalent substituent formed by removing one hydrogen atom from a heterocycle containing at least one nitrogen atom, and L represents a divalent linking group; and provides a cleaning method using the cleaning agent.
    Type: Application
    Filed: September 11, 2008
    Publication date: April 2, 2009
    Applicant: FUJIFILM CORPORATION
    Inventor: Yoshinori NISHIWAKI
  • Patent number: 7511152
    Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, age-related mild cognitive impairment, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, irritable bowel syndrome, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: March 31, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Mark L. Greenlee, Dongfang Meng, Donald M. Sperbeck, Kenneth J. Wildonger
  • Patent number: 7511042
    Abstract: Disclosed are compounds of formula (I) Where Ar1, X, R3, R4, R5 and R6 are defined herein. The compounds of the invention inhibit production of cytokines and are thus useful for treating cytokine mediated diseases. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: March 31, 2009
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Derek Cogan, Daniel R. Goldberg, Abdelhakim Hammach, Matthew Russell Netherton, Ronald A. Aungst
  • Publication number: 20080287503
    Abstract: The invention relates to carbamoylbenzotriazole derivatives of general formula (I), which are defined as cited in the description, to their pharmaceutically applicable salts and to their use as medicaments.
    Type: Application
    Filed: April 9, 2008
    Publication date: November 20, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Stefan Petry, Gerhard Zoller, Norbert Tennagels, Gunter Muller
  • Publication number: 20080269228
    Abstract: The present invention relates to novel hydrazide-containing compounds of Formula I or Formula II, including pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Application
    Filed: April 26, 2007
    Publication date: October 30, 2008
    Inventors: JOEL D. MOORE, ERIC L. ELLIOTT, YAT SUN OR, ZHE WANG
  • Publication number: 20080221086
    Abstract: The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein R1 represents heteroaryl; -carbocyclyl-heteroaryl; -alkenylheteroaryl or -alkylheteroaryl; R2 represents alkyl which may optionally be substituted by hydroxy; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl and hydroxy; aryl; -aryl-heteroaryl; -heteroaryl-aryl; -aryl-heterocyclyl; H; heteroaryl; or heterocyclyl, which may optionally be substituted by one or more groups selected from alkyl oxo and hydroxy; R3 represents alkyl which may optionally be substituted by one of more groups selected from alkoxy, amine, hydroxy and —C(O)Oalkyl; carbocyclyl, which may optionally be substituted by one or more groups selected from alkyl haloalkyl, alkoxy, amine, hydroxy and —C(O)Oalkyl; -alkyl-aryl; -alkyl(aryl)2; -alkyl-heteroaryl; -alkyl(he
    Type: Application
    Filed: November 8, 2007
    Publication date: September 11, 2008
    Applicant: PROBIODRUG AG
    Inventors: Michael Thormann, Michael Altmstetter, Andreas Treml, Ulrich Heiser, Mirko Buchholz, Andre J. Niestroj
  • Publication number: 20080221675
    Abstract: Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization.
    Type: Application
    Filed: May 22, 2008
    Publication date: September 11, 2008
    Applicant: ALCON, INC.
    Inventor: Douglas C. Schlueter
  • Patent number: 7402606
    Abstract: Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: July 22, 2008
    Assignee: SmithKline Beecham Corporation
    Inventors: David Gene Barrett, John G. Catalano, David Norman Deaton, Aaron Bayne Miller, John A. Ray, Vicente Samano
  • Patent number: 7388006
    Abstract: The present invention relates to non-steroidal progestins of the general formula (I) wherein R1 and R2 are independently of each other —H or —F, R3 is —CH3 or —CF3, and Ar is or a pharmaceutically acceptable derivative or analogue thereof. These progestins are suitable for selectively modulating progesterone receptor mediated effects in different target tissues, particularly in uterine tissue versus breast tissue. Therefore, the progestins of the present invention, optionally in combination with estrogens, may be used for contraception (in particular in estrogen-free oral contraceptives), hormone replacement therapy and the treatment of gynecological disorders. The present invention furthermore relates to methods for selectively modulating progesterone receptor mediated effects in different target tissues or organs.
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: June 17, 2008
    Assignee: Bayer Schering Pharma AG
    Inventors: Norbert Schmees, Manfred Lehmann, Ulrike Fuhrmann, Peter Muhn, Christa Hegele-Hartung, Michael Klotzbuecher
  • Publication number: 20080132507
    Abstract: A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic or prophylactic agents for diseases associated with thrombus formation. wherein R1a, R1b, R1c and R1d each independently represent hydrogen, etc., R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc., Z1, Z2 and Z3 each independently represent hydrogen, etc., Z4 represents hydrogen, etc. and X represents a single bond or —CO—, etc.
    Type: Application
    Filed: October 13, 2005
    Publication date: June 5, 2008
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Richard Clark, Shinsuke Hirota, Hiroshi Azuma, Kazunobu Kira, Nobuhisa Watanabe, Tadashi Nagakura, Tatsuo Horizoe
  • Publication number: 20080119648
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 22, 2008
    Inventors: Jerome C. Bressi, Anthony R. Gangloff, Lily Kwok
  • Publication number: 20080119658
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 22, 2008
    Inventors: Jerome C. Bressi, Anthony R. Gangloff, Lily Kwok
  • Publication number: 20080114037
    Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with HDAC that comprise a compound selected from the group consisting of: wherein the substituents are as defined herein.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 15, 2008
    Inventors: Jerome C. Bressi, Anthony R. Gangloff, Lily Kwok
  • Publication number: 20080114177
    Abstract: Fluorinated benzotriazole compounds may be prepared by contacting a fluorochemical monofunctional compound, such a fluorinated alcohol, with a carboxybenzotriazole in the presence of a coupling agent, and an optional amine catalyst.
    Type: Application
    Filed: November 15, 2006
    Publication date: May 15, 2008
    Inventors: Larry D. BOARDMAN, George W. Griesgraber
  • Patent number: 7361767
    Abstract: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: April 22, 2008
    Assignee: 3M Innovative Properties Company
    Inventors: Karl E. Benson, Moses M. David, Cary A. Kipke, Brinda B. Lakshmi, Charles M. Leir, George G. Moore, Rahul Shah
  • Patent number: 7157586
    Abstract: Benzotriazole UV absorbers substituted with a ultra long ester or amide moiety wherein the ester or amide group is a hydrocarbyl group of 25 to 100 carbon atoms or is a group of alkyl of 25 to 100 carbon atoms interrupted by 5 to 39 oxygen atoms and terminated with an omega-OH or an omega-OR group exhibit excellent stabilization efficacy while they concomitantly do not bloom when incorporated into polyolefin films. These benzotriazole UV absorbers also provide excellent protection to white, dyed, dipped, unscented and/or scented candle wax from discoloration and degradation.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: January 2, 2007
    Assignee: Ciba Specialty Chemcials Corporation
    Inventors: Mervin Wood, Ramanathan Ravichandran, Douglas Wayne Horsey, Anunay Gupta, Deborah DeHessa, Luther A. R. Hall, Andrea Smith, Stephen Mark Andrews
  • Patent number: 7084280
    Abstract: The invention relates to benzotriazol-1-yl-aminoacetonitrile compounds and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: August 1, 2006
    Inventors: Pierre Ducray, Thomas Goebel, Noelle Gauvry
  • Patent number: 7019003
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 28, 2006
    Assignee: Smithkline Beecham Corporation
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen, IV, Jinhwa Lee, Daniel J. Mercer
  • Patent number: 6949556
    Abstract: The present invention relates to compounds of general formula (I), wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH—(C1-C3-alkyl), B and C are independently CH2 or CH—(C1-C3-alkyl), and R5 is an aryl or heteroaryl group optionally substituted by the substituents listed in the specification.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: September 27, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Hartmut Strobel, Paulus Wohlfart
  • Patent number: 6939967
    Abstract: Process for production of non-proteinogenic L-amino acids by direct fermentation of a microorganism strain known per se having a deregulated cysteine metabolism in a manner known per se, which comprises adding, during the fermentation, a nucleophilic compound to the fermentation batch in a manner such that this leads to the production of non-proteinogenic L-amino acids by the microorganism strain.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 6, 2005
    Assignee: Consortium für elektrochemische Industrie GmbH
    Inventor: Thomas Maier
  • Patent number: 6930136
    Abstract: Benzotriazole adducts contain a benzotriazole segment and a segment with a curable and polymerizable functionality, or an adhesion promoting functionality, particularly suitable for use on metal substrates or in adhesive, sealant or coating compositions for use in proximity to metal substrates.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: August 16, 2005
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Osama M. Musa, Harry Richard Kuder
  • Patent number: 6869913
    Abstract: Novel pyridazin-3-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R1 is haloalkyl; R2 and R3 are hydrogen, alkyl, haloalkyl, or alkoxyalkyl; and Q is [Q-1], [Q-2], [Q-3], [Q-4] or [Q-5]. Also provided are their use and intermediates for their production.
    Type: Grant
    Filed: February 9, 2004
    Date of Patent: March 22, 2005
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tadashi Katayama, Shinichi Kawamura, Yuzuru Sanemitsu, Yoko Mine
  • Patent number: 6800676
    Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position and/or the 5-position of the phenyl ring by a phenyl moiety which is substituted by a heteroatom are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: October 5, 2004
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Mervin G. Wood, Stephen D. Pastor, Jacqueline Lau, Michael DiFazio, Joseph Suhadolnik
  • Patent number: 6790955
    Abstract: The invention relates to the preparation of compounds (I) in which A═H or acyl and R1, R2, R3, R, n, X, Y and Z are as defined in claim 1 by halogenation and rearrangement of compounds (II) (optionally salt) to give compounds (III) a) ammonolysis of (III) to (IV), reduction of the nitro group and reaction with carbamate (salts) (VI) of the formula Ar—OCO—N(M)-Het, where Ar=phenyl, M═H or cation and Het=heterocycle from formula (I), to give compounds (I) (A═H), or b) ammonolysis of (III) to (IV), reaction with carbamate (salt) (VI) and reduction of resulting compounds (VII) at the NO2 group to give compounds (I) (A═H), or c) reaction of (III) with cyanates and amines (VII) of the formula HNR3-Het and reduction of the resulting compound (VII) at the NO2 group to give compounds (I) (A═H) and optional acylation if A is to be other than H.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: September 14, 2004
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Gerhard Schnabel, Jan Vermehren, Lothar Willms
  • Publication number: 20040167186
    Abstract: The invention relates to the novel modification A or A′ of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide of the formula 1
    Type: Application
    Filed: February 26, 2004
    Publication date: August 26, 2004
    Inventors: Robert Portmann, Urs Christoph Hofmeier, Andreas Burkhard, Walter Scherrer, Martin Szelagiewicz
  • Publication number: 20040127484
    Abstract: Benzotriazoles of formula I 1
    Type: Application
    Filed: October 14, 2003
    Publication date: July 1, 2004
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Stefan Petry, Karl-Heinz Baringhaus, Norbert Tennagels, Guenter Mueller, Hubert Heuer
  • Patent number: 6703510
    Abstract: Compounds of formula I or II where R is an aryl moiety, such as phenyl, naphthyl or biphenylyl, or is phenyl substituted by one or more trifluoromethyl, bromo or cyano, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a arylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: March 9, 2004
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Stephen D. Pastor, Andrew B. Naughton, Robert Detlefsen, Mervin G. Wood, Joseph Suhadolnik, Anthony DeBellis, Deborah DeHessa
  • Patent number: 6664395
    Abstract: The present invention relates to novel benzotriazoles of the formula I wherein Het is an optionally substituted 5-membered heterocycle containing one to two heteroatoms selected from nitrogen, sulfur and oxygen wherein at least one of said heteroatoms atoms must be nitrogen; R2 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; R3 is selected from the group consisting of hydrogen, (C1-C6)alkyl or other suitable substituents; s is an integer from 0-5; to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, repurfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: December 16, 2003
    Assignee: Pfizer Inc
    Inventors: Michael A. Letavic, Mark A. Dombroski, Kim F. McClure, Ellen R. Laird
  • Patent number: 6653308
    Abstract: The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: November 25, 2003
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company
    Inventors: Huiping Guan, Congxin Liang, Li Sun, Peng Cho Tang, Chung Chen Wei, Tomas Vojkovsky, Qingwu Jin, Paul M. Herrinton, Michael A. Mauragis
  • Patent number: 6653484
    Abstract: Triazine, benzotriazole and benzophenone derivatives which are substituted or bridged with polyoxyalkylene groups, according to claim 1, and their use as UV absorbers, especially in photographic materials, in inks, including inkjet inks and printing inks, in transfer prints, in paints and varnishes, organic polymeric materials, plastics, rubber, glass, packaging materials, in sunscreens of cosmetic preparations and in skin protection compositions.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: November 25, 2003
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Vien Van Toan, Andreas Valet, Pascal Hayoz
  • Publication number: 20030204085
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: July 30, 2002
    Publication date: October 30, 2003
    Inventors: Arthur G. Taveras, Cynthia J. Aki, Richard W. Bond, Jianping Chao, Michael Dwyer, Johan A. Ferreira, Jonathan A. Pachter, John J. Baldwin, Bernd Kaiser, Ge Li, J. Robert Merritt, Kingsley H. Nelson, Laura L. Rokosz
  • Publication number: 20030191242
    Abstract: The invention relates to metathesis polymers wherein an aromatic group that has UV-light absorbing properties is attached with a bridge group to the polymer. Also disclosed is a polymerisable composition comprising a catalytically effective amount of a penta- or hexavalent ruthenium or osmium carbene catalyst, the process for preparing the metathesis polymer by applying the reaction conditions of Ring Opening Metathesis Polymerisation (=ROMP) to the polymerisable composition; and various technical applications of the metathesis polymers.
    Type: Application
    Filed: November 29, 2002
    Publication date: October 9, 2003
    Inventors: Alessandro Zedda, Dario Lazzari, Massimiliano Sala, Michela Bonora, Manuele Vitali, Paul Adriaan Van Der Schaaf
  • Publication number: 20030149072
    Abstract: Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.
    Type: Application
    Filed: December 4, 2002
    Publication date: August 7, 2003
    Inventors: Patrick Mailliet, Marc Capet, Gilles Tiraboschi, Thomas Caulfield
  • Patent number: 6562972
    Abstract: The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous alkaline suspension of a 5- or 6-halomethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: May 13, 2003
    Assignee: Air Products and Chemicals, Inc.
    Inventor: Juan Jesus Brudeniuc
  • Patent number: 6559308
    Abstract: The present invention relates to a method for preparing quinoxaline-5- and 6-carboxylic acids. The method comprises contacting an aqueous suspension of a 5- or 6-hydroxymethyl quinoxaline with oxygen in the presence of a transition metal catalyst, to form the respective quinoxaline-5- or 6-carboxylic acid. The method for oxidizing benzylic methyl groups may also be employed to prepare a wide variety of heterocyclic carboxylic acid compounds.
    Type: Grant
    Filed: August 9, 2001
    Date of Patent: May 6, 2003
    Assignee: Air Products and Chemicals, Inc.
    Inventor: Juan Jesus Burdeniuc
  • Patent number: 6548678
    Abstract: Disclosed is a method for producing 5-phenoxycarbonylbenzotriazole (I): by reacting 1H-benzotriazole-5-carboxylic acid (II): with diphenyl carbonate (III):
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: April 15, 2003
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Keiko Yamamoto, Takashi Kamikawa
  • Patent number: 6548525
    Abstract: The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D is substituted ortho to G on E and may be CH2NH2, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: April 15, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Robert A. Galemmo, Jr., Lori L. Bostrom, Donald J. P. Pinto, Karen A. Rossi
  • Patent number: 6541423
    Abstract: The invention relates to pyrazolyl derivatives of benzo-condensated, unsaturated 5-membered nitrogen heterocycles of the general formula (I), wherein X represents N or a group C—R3; Y is O, S, SO, SO2 or NR4 or X—Y is S═N, and wherein X means sulfur, and the variables R1, R2 and Pz have the meanings indicated in claim 1. The invention, further relates to a method of producing said compounds, to agents that contain them and to their use as herbicidal agents.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: April 1, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Guido Mayer, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Ulf Misslitz, Ulf Neidlein, Matthias Witschel, Michael Rack, Thorsten Volk, Martina Otten, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6515124
    Abstract: Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: February 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Patent number: 6500851
    Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: December 31, 2002
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milot, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
  • Patent number: 6498004
    Abstract: This invention provides a photographic element comprising at least one silver halide emulsion layer in which the silver halide is sensitized with a compound of the formula (a): &Dgr;−(t)m−XY′  (a) XY′−(t)m−&Dgr;  (b) &Dgr;−(t)m−XY′−(t)m−&Dgr;  (c) wherein &Dgr; is protective group that is eliminated during development of the photographic element, t is a timing group, m is an integer from 0 to 3, and XY′ is a fragmentable electron donor moiety in which X is an electron donor group and Y′ is a leaving proton H or a leaving group Y, with the proviso that if Y′ is a proton, a base, &bgr;−, is present in the emulsion or is covalently linked directly or indirectly to X, and wherein: 1) X—Y′ has an oxidation potential between 0 and about 1.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: December 24, 2002
    Assignee: Eastman Kodak Company
    Inventors: Jerome R. Lenhard, Annabel A. Muenter, Stephen A. Godleski, Paul A. Zielinski, Deepak Shukla, Donald R. Diehl
  • Patent number: 6489383
    Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position or at the 5-position of the phenyl ring by a 1,1-diphenylalkyl moiety, particularly a 1,1-diphenylethyl group, are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: December 3, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Mervin G. Wood, Ramanathan Ravichandran, Joseph Suhadolnik, David Bramer, Jacqueline Lau, Anthony DeBellis
  • Patent number: 6469004
    Abstract: The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as MEK inhibitors, particularly in the treatment of proliferative diseases such as cancer.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: October 22, 2002
    Assignee: Warner-Lambert Company
    Inventors: Stephen Barrett, Haile Tecle, Alexander J. Bridges
  • Patent number: 6452018
    Abstract: 2-(2′-hydroxyphenyl)benzotriazoles having general formula (I). The above 2-(2′-hydroyzphenyl)benzotriazoles having general formula (I) are useful as heat, oxygen and light stabilizers for organic polymers. In particular they are useful as UV stabilizers for organic polymers.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: September 17, 2002
    Assignee: Great Lakes Chemical Italia S. r. L.
    Inventors: Rosa Maria Riva, Carlo Neri, Barbara Granelli
  • Patent number: 6451887
    Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position and/or the 5-position of the phenyl ring by &agr;-cumyl moiety which is substituted by a heteroatom are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: September 17, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Mervin G. Wood, Joseph Suhadolnik, Ramanathan Ravichandran, Jacqueline Lau, Carmen Hendricks-Guy, Christophe Bulliard
  • Patent number: 6407254
    Abstract: 2-(2′-hydroxyphenyl)benzotriazoles having general formula (I). The above 2-(2′-hydroxyphenyl)benzotriazoles are useful as light stabilizers for organic polymers.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: June 18, 2002
    Assignee: Great Lakes Chemical (Europe) GmbH
    Inventors: Rosa Maria Riva, Carlo Neri, Rosalba Colombo
  • Patent number: 6392056
    Abstract: 2H-Benzotriazole UV absorbers substituted at the 3-position or at the 5-position of the phenyl ring by a 1,1-diphenylalkyl moiety, particularly a 1,1-diphenylethyl group, are particularly photostable in automotive coatings, and are of low color and exhibit low volatility in thermoplastic compositions.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: May 21, 2002
    Assignee: Ciba Specialty Chemical Corporation
    Inventors: Mervin G. Wood, Ramanathan Ravichandran, Joseph Suhadolnik, David Bramer, Jacqueline Lau, Anthony DeBellis
  • Patent number: 6387992
    Abstract: Compounds of formula I or II where R is a heteroaryl moiety, such as 3-pyridyl, or T is a heteroaryl moiety, such as thien-2,5-diyl, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like, are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a heteroarylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: May 14, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Stephen D. Pastor, Anthony DeBellis, Mervin G. Wood, Joseph Suhadolnik, Deborah DeHessa, Ramanathan Ravichandran
  • Patent number: 6376065
    Abstract: The invention provides compounds having the formula: wherein Rf is CnF2n+1—(CH2)m—, wherein n is 1 to 22 and m is 0, or an integer from 1 to 3; X is —CO2—, —SO3—, —CONH—, —O—, —S— a covalent bond, —SO2NR—, or —NR—, wherein R is H or C1 to C5 alkylene; Y is —CH2— wherein z is 0 or 1; and R1 is H, lower alkyl or Rf—X—Yz— with the provisos that when X is —S—, or —O—, m is 0, sand z is 0, n is ≧7 and when X is a covalent bond, m or z is at least 1, and uses thereof.
    Type: Grant
    Filed: September 20, 2000
    Date of Patent: April 23, 2002
    Assignee: 3M Innovative Properties Company
    Inventors: Gary A. Korba, Mark E. Mueller, Robert A. Sinclair
  • Patent number: 6372759
    Abstract: This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: April 16, 2002
    Assignee: Eli Lilly and Company
    Inventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Steven Edward Hall, David Kent Herron, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milot, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee