Patent number: 6326500
Abstract: Compounds of formula (I)
and salts thereof, wherein
R1 is hydrogen, halo, cyano, cyanoalkyl, alkyl, alkoxy, phenoxy, phenyl, alkoxycarbonyl, —NR13R14, —N(R15)SO2R16, haloalkoxy, haloalkyl, arylalkoxy, hydroxy, phenylalkyl, alkoxycarbonylvinyl, —SOnR7, alkoxycarbonylalkyl, carboxylalkyl, —CONR11R12, carbamoylvinyl, —O—SO2R21, 4,5-dihydrothiazol-2-yl, 4,4-dimethyl-2-oxazolin-2-yl, —NR60R61 or —(O)z—L3—G (G=−NR22R23, —SOmR26, CONR27R28 or —OR29);
R2 and R3 are independently hydrogen halo, alkyl, alkoxy, —NR13R14, haloalkoxy, haloalkyl, hydroxy, —SOnR7 or —NR60R61;
L1 is a bond, alkylene, cycloalkylene or cycloalkylidene;
T is a bond, O, S, SO, SO2, CO or 1,3-dioxolan-2-ylidene;
L2 is alkylene, cycloalkylene or cycloalkylidene;
R6 is hydrogen or alkyl;
Q is alkylene; and
Y is imidazolyl,
which are antiinflammatory, antiallergic and immunodulant agents.
Type:
Grant
Filed:
December 27, 2000
Date of Patent:
December 4, 2001
Assignee:
Abbott Laboratories
Inventors:
David John Calderwood, Adrian John Fisher, James Edward Jeffery, Colin Gerhart Pryce Jones, Paul Rafferty
Patent number: 6242474
Abstract: Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided.
wherein Nu represents a 5- or 6-membered aromatic ring; ch1 and ch2 each represents a cross-linking group; and A represents an aromatic ring.
These compounds have blood sugar-depressing activity or PDE 5 inhibitory activity and are useful as medicines for treating impaired glucose tolerance, diabetes, diabetic complications, syndrome of insulin-resistance, polycystic ovary syndrome, hyperlipidemia, atherosclerosis, cardiovascular disorders, hyperglycemia, hypertension, stenocardia, pulmonary hypertension, congestive heart failure, glomerulopathy, tubulointerstitial disorders, renal failure, angiostenosis, distal angiopathy, cerebral apoplexy, chronic reversible obstructions, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by enteromotility disorders, impotence, nephritis, cachexia, pancreatitis, restenosis after PTCA, etc.
Type:
Grant
Filed:
March 21, 2000
Date of Patent:
June 5, 2001
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
Inventors:
Noritsugu Yamasaki, Takafumi Imoto, Takahiro Hiramura, Osamu Onomura, Masahiro Nishikawa, Hiroshi Kayakiri, Yoshito Abe, Hitoshi Hamashima, Hitoshi Sawada