Patent number: 5847159
Abstract: 1-?.omega.-(3,4-Dihydro-2-naphthalenyl)alkyl!cyclic amine derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are H, halogen, OH, alkyl, alkoxy, hydroxymethyl, etc., or R.sup.1 and R.sup.2 combine to form methylenedioxy, trimethylene, etc., R.sup.3 is H, etc., R.sup.4 is H, OH, alkyl, etc., R.sup.5 is H, alkyl, etc., p is integer of from 2 to 6, and q is integer of from 3 to 7, provided that when p is 2, and q is 5, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are not simultaneously H, or salts thereof, or N-oxide derivatives thereof, or a process for preparing the same, or pharmaceutical composition containing the same. The compounds of the present invention show potent inhibitory effect on the micturition reflex, and are useful as agents for treatment of frequent urination and urinary incontinence.
Type:
Grant
Filed:
October 14, 1997
Date of Patent:
December 8, 1998
Assignee:
Dainippon Pharmaceutical Co., Ltd.
Inventors:
Naoki Kai, Aki Kanehira, Toshiya Morie, Katsuhiko Hino, Katsuyoshi Kawashima, Isao Shimizu, Kazuhisa Akiyama
Patent number: 5506260
Abstract: Substituted-1-arylpyrrole compounds of general formula (I) below, are useful as pesticides, in particular for the control of insects, arachnids, and nematodes. Processes to make the compounds and intermediates used for their preparation are described. Additionally, compositions containing the compounds and methods of use therefore are provided. Preferred compounds are the compounds of general formula (I) ##STR1## wherein typically preferred substituents are: X is halogen or a group R.sup.5 S(O).sub.n, in which n is 0, 1, or 2 and R.sup.5 is CH.sub.3, CF.sub.3, CCl.sub.3, CF.sub.2 Cl, CFCl.sub.2, CF.sub.2 Br, CHF.sub.2, CHCl.sub.2 or CHClF;R.sup.1 is H, F, Cl, Br, OCH.sub.3, SCH.sub.3, or CH.sub.3 optionally substituted;R.sup.2 is CN;R.sup.3 is H, F, Cl, Br, OCH.sub.3, or CH.sub.3 optionally substituted;Y is CF.sub.3, CF.sub.3 O, H, F, Cl or Br;X.sup.1 and X.sup.4 are individually H, F, Cl, Br, CH.sub.3, OCH.sub.3 or SCH.sub.3 ; andX.sup.2 and X.sup.3 are each H.
Type:
Grant
Filed:
February 10, 1993
Date of Patent:
April 9, 1996
Assignee:
Rhone-Poulenc AG Company
Inventors:
Russell J. Outcalt, Philip R. Timmons, Susan M. Cramp, Patricia L. Kwiatkowski, Anibal Lopes, Paul A. Cain, David N. Sinodis, Lee S. Hall, Jean-Pierre A. Vors
Patent number: 5232978
Abstract: Novel 1-(2-arylethyl)-pyrrolidines of the formula ##STR1## in which, Ar is a phenyl group which is unsubstituted or monosubstituted by OH, --O--CO--NH.sub.2, --O--CO--NHA, --O--CO--NA.sub.2, NH.sub.2, --NH--CHO, --NH--CO--A, --NH--CO--NH.sub.2, --NH--CO--NHA or NH--SO.sub.2 --A,R.sup.1 is A,R.sup.2 is a phenyl, naphthyl, thienyl, benzothienyl or pyridyl group which is unsubstituted or mono- or disubstituted by A, Hal, CF.sub.3, OH, OA, --O--CO--NH.sub.2, --O--CO--NHA, --O--CO--NA.sub.2, NO.sub.2, NH.sub.2, --NH--CHO, --NH--CO--A, --NH--CO--NH.sub.2, --NH--CO--NHA, --NH--SO.sub.2 A, --CO--A, --CONH.sub.2, --CONHA, --CONA.sub.2, --CH.sub.2 --CONH.sub.2 and/or --O--CH.sub.2 --CONH.sub.2,R.sup.3 is OH or CH.sub.2 OH,A is alkyl with 1-4 C atoms andHal is F, Cl, Br or I,or a pharmaceutically acceptable salt thereof for use as an analgesic in humans and veterinary medicine.
Type:
Grant
Filed:
November 1, 1991
Date of Patent:
August 3, 1993
Assignee:
Merck Patent Gesellschaft Mit Beschrankter Haftung
Inventors:
Rudolf Gottschlich, Karl-August Ackermann, Helmut Prucher, Andrew Barbar, Anton Haase, Hartmut Greiner, Gerd Bartoszyk