Abstract: Polyfunctional .alpha.-diazo-.beta.-keto esters of the general formula I are described ##STR1## in which R.sup.1 denotes an aliphatic, cycloaliphatic or araliphatic or aromatic radical having 4 to 20 carbon atoms, in which individual CH.sub.2 groups can be replaced by oxygen or sulfur atoms or by N-- or NH groups and/or contain keto groups,X denotes an aliphatic, cycloaliphatic, carbocyclic, heterocyclic or araliphatic radical having 2 to 22 carbon atoms, in which individual CH.sub.2 groups can be replaced by oxygen or sulfur atoms or by the groups ##STR2## in which R.sup.2 and R.sup.3 independently of one another represent hydrogen or an aliphatic, carbocyclic or araliphatic radical,m denotes an integer from 2 to 10 andn denotes an integer from 0 to 2,whereinm-n is .gtoreq.2.The compounds mentioned are used as photoactive components in radiation-sensitive mixtures.

Abstract: The invention relates to a new process for the purification, by distillation, of thermolabile compounds wherein a thermolabile compound is introduced into a twin screw extruder which is heated, in at least one zone, to the boiling temperature of the compound. The volatilized compound is drawn off and condensed.

Abstract: Lactones of the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom or an alkyl group and n represents an integer of 0 to 10, are produced by reacting a diol, formaldehyde and carbon monoxide in the presence of copper (I) or silver carbonyl complex catalyst in a strong acid.

Abstract: The invention relates to a meso-lactide having a melting point of 52.8.degree. C., processes for its preparation, and its use in the preparation of resorbable polymers and copolymers.

Abstract: The process described makes it possible to obtain optically pure 4-amino-3-hydroxycarboxylic acids by means of a series of stereoselective steps. The starting material is an alpha-amino acid in the L or D configuration, with which Meldrum's acid is reacted. The resulting pyrrolone derivative is reduced prior to opening of the pyrrolidine ring. The invention also relates to the new products obtained by the said process and to the pyrrolone derivatives obtained as intermediates.

Abstract: A process for the preparation of optically active 3-demethylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups.

Abstract: A stereoselective process is described for preparing optically active alpha,beta-disubstituted carbonyl compounds, comprising forming an acetal between an alpha,beta-unsaturated aldehyde or ketone and tartaric acid or a derivative thereof, halogenating the product thus obtained, and restoring the carbonyl compound.

Abstract: Disclosed is a process for the production of highly pure lactide, especially having a sufficiently high purity to be usable as a raw material for the synthesis of polymers, by heating a 2-halopropionate in a non-aqueous solvent.

Abstract: Disclosed are new 1,3-dioxenones having the formulae ##STR1## in an optically pure state, a process for preparing same and the use thereof.

Abstract: 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.

Abstract: This invention relates to an improved process for preparing highly pure cyclic esters by heating a polymer of the corresponding .alpha.-hydroxy acid or its ester or a copolymer of .alpha.-hydroxy acid or its ester and a thermally stable polyether in the presence of an inert gas at atmospheric pressure. The cyclic ester is carried from the reaction with the inert gas to a solvent system.

Abstract: Novel substituted dioxanones obtained from (R)-3-hydroxybutyric acid, for example 2,2-dimethoxy-6-methyl-1,3-dioxan-4-one, a method for their preparation and processes using the dioxanones as starting material. The dioxanones can be used in particular as intermediates in the preparation of (S)-4-methyl-.beta.-butyrolactone.

Abstract: The invention relates to a method for preparing high molecular polylactic acid or copolymers of lactic acids using lactide that is purified by extraction with water.

Abstract: 6-Etherified hydroxy -2-(4',8',12'-trimethyl-5'-tridecenyl)-2,5,7,8-tetramethylchromans with an oxo or hydroxy substituent at the 2' position which may be substituted with an arylsulfonyl or a carboxyalkyl at the 3' position and containing a single or double bond at the 11 position, said chromans being intermediates for producing natural vitamin E.

Abstract: A process for making highly pure cyclic esters by heating a copolymer of .alpha.-hydroxy acid or its ester on a thermally stable polyether core.

Abstract: New compounds of the formula ##STR1## a process for their preparation and their use as intermediates for insecticides.

Abstract: The synthesis of novel strained bicyclic lactones and their ring-opening polymerization to high molecular weight polyester polymers is disclosed.

Abstract: A process for the purification of glycolide which comprises dissolving the glycolide to be purified in a suitable organic solvent, adding alumina to the resulting solution to form a slurry wherein the alumina is in intimate contact with the dissolved glycolide, stirring the slurry under controlled conditions for a period of 1 to 60 minutes, and filtering to remove the alumina and, if desired, evaporating to remove the solvent and recovering the purified glycolide; and the production of suture-grade polyglycolic acid by the polymerization of the resulting purified glycolide.

Abstract: A process for producing Meldrum's acid in excellent yield wherein acetic anhydride is added in a slow, controlled manner to a mixture of acetone, malonic acid and an acid catalyst.

Abstract: A process for producing 1,3-dioxin-4-one derivatives having a lower alkyl group at 2-position and useful as a starting raw material for prostaglandins, with a high yield is provided, which process comprises reacting formyl Meldrum's acid with a lower aliphatic carbonyl compound of 2 to 4 carbon atoms in a solvent containing the carbonyl compound at 100.degree. to 120.degree. C., while portionwise adding the acid into the solvent, the total quantity of the acid added being 0.2 mol or less per liter of the solvent.

Abstract: Disclosed are novel 5-halo-4H-1,3-dioxin-4-ones and their preparation by treating a compound having the formula ##STR1## with X.sub.2 or SO.sub.2 X.sub.2 wherein X is Cl or Br.

Abstract: Disclosed herein are antisecretory agents represented by the formula ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is lower alkylthio, (2-thienylmethyl)thio or SCH.sub.2 -- COOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl, or R.sup.1 and R.sup.2 are independently a lower alkylthio or (2-thienylmethyl)thio, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a 2-imidazolidinylidene; and R.sup.3 and R.sup.4 are each the same lower alkyl, or R.sup.3 and R.sup.4 together with the carbon atoms to which they are attached form a cyclohexane wherein said carbon atom is a spiro atom in common with the cyclohexane ring and the adjoining dioxane ring.

Abstract: An alkyl 3-hydroxy-4-(4-hydroxyphenoxy)pentanoate having the formula ##STR1## wherein R is an alkyl or substituted alkyl group ranging from about 1 to about 18 carbon atoms.

Abstract: The present invention relates to a process for the production of organic polyisocyanates containing at least partly blocked isocyanate groups characterized in that specific cyclic dicarbonyl compounds are used as the blocking agent. The present invention also relates to the polyisocyanates containing at least partly blocked isocyanate groups obtainable by this process and to the use of the polyisocyanates containing at least partly blocked isocyanate groups obtainable by this process as reactants for isocyanate-reactive compounds for the production of isocyanate polyaddition products.The present invention also relates to the use of polyisocyanates containing at least partly blocked isocyanate groups obtainable by the above process for the production of aqueous stoving lacquers and to the use of these polyisocyanates for the production of aqueous polyisocyanate solutions or dispersions.

Abstract: The invention concerns the novel compounds dialkyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate IIIa and dialkyl 2-(3-fluoro-4-aminophenyl)-2-methylmalonate IVa useful as intermediates in an improved process for making 2-(2-fluoro-4-biphenylyl)propionic acid, known as flurbiprofen, having the formula ##STR1## and ester thereof. It has anti-inflammatory activity which is about 240 times that of aspirin and analgesic activity which is about 180 times that of aspirin in standard laboratory tests. However, despite this high activity, the toxicity (LD.sub.50) is only 1.2 to 2.4 times greater than that of aspirin in standard laboratory tests.Also within the invention is a novel method of making the above intermediates and analogs thereof useful to prepare corresponding biaryl compounds which have pharmaceutical uses.

Abstract: 4-methyl-2,5-dioxabicyclo-[4,4,0]-decan-3-one having the formula ##STR1## its synthesis, its use as a perfumery agent and as an olefactant component in perfume compositions and as an odorant agent for technical products.

Abstract: 3-(2-Methoxy-phenoxy)-3-methyl-benzo-2,4-dioxacyclohexanone of formula ##STR1## a process for its preparation through reaction among the chloride of acetylsalicylic acid, guaiacole and pyridine; pharmaceutical compositions containing it.

Abstract: Carbamate-sulfenyl-carba moyl fluoride compounds are valuable insecticidal compositions and are also useful intermediates in the production of bis-carbamate compounds.