The Lactone Ring Is Six-membered Patents (Class 549/273)
  • Patent number: 10287312
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: May 14, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adam R. Renslo, Erica M. W. Lauterwasser, Shaun D. Fontaine, Benjamin B. Spangler, James A. Wells
  • Patent number: 10202624
    Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: February 12, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Kechun Zhang, Mingyong Xiong
  • Patent number: 10160741
    Abstract: Methods for recovering monomers from polymers, such as polyurethanes (including thermoset polyurethanes) include heating the polymer to depolymerize the polymer and release the monomer. The monomer may be directly recovered. The polymer may include a poly(?-methyl-?-valerolactone) (PMVL) block and the monomer recovered may be ?-methyl-?-valerolactone (MVL).
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: December 25, 2018
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Marc Andrew Hillmyer, Tessie Rose Panthani, Marie Elizabeth Vanderlaan, Deborah Kay Schneiderman, Alexander Michael Rauch Mannion, Derek Charles Batiste, Christopher Ward Macosko, Jay Z. Wang, Frank S. Bates
  • Patent number: 9815808
    Abstract: Methods for recovering monomers from polymers, such as polyurethanes (including thermoset polyurethanes) include heating the polymer to depolymerize the polymer and release the monomer. The monomer may be directly recovered. The polymer may include a poly(?-methyl-?-valerolactone) (PMVL) block and the monomer recovered may be ?-methyl-?-valerolactone (MVL).
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: November 14, 2017
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Marc Andrew Hillmyer, Tessie Rose Panthani, Marie Elizabeth Vanderlaan, Deborah Kay Schneiderman, Alexander Michael Rauch Mannion, Derek Charles Batiste, Christopher Ward Macosko, Jay Z. Wang, Frank S. Bates
  • Patent number: 9796812
    Abstract: Provided is a polymer obtained by homopolymerizing a lactone monomer. The polymer contains a structural unit having a lactone ring containing three or more carbon atoms, wherein at least one of the carbon atoms, except for C of —C(?O)O—, of the lactone ring forms a part of a main chain; and wherein at least one of the carbon atoms, except for C of —C(?O)O—, which forms the lactone ring and is other than the carbon atom(s) forming a part of the main chain is bridged with an atom of the main chain.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: October 24, 2017
    Assignees: THE UNIVERSITY OF TOKYO, FUJIFILM Corporation
    Inventors: Takafumi Hosokawa, Toshihide Yoshitani, Shingo Ito, Kyoko Nozaki, Ryo Nakano
  • Publication number: 20150118382
    Abstract: The object of this application is to non-enzymatically improve flavor of a butter oil and fat composition. The present invention can enrich lactones in the oil and fat composition by the following steps of keeping temperature of the oil and fat composition containing between 300 ppm and 1200 ppm of moisture content at the temperature where a solid fat exists in the oil and fat composition, and non-enzymatically producing ?-lactone or ?-lactone from triglyceride containing 4- or 5-hydroxy fatty acid in the oil and fat composition, or adding to the oil and fat composition an additive agent (such as, sucrose) which has an ability to form hydrogen bonds with water molecules, keeping temperature of the oil and fat composition at the temperature between 40 and 60° C., and non-enzymatically producing ?-lactone or ?-lactone from triglyceride containing 4- or 5-hydroxy fatty acid in the oil and fat composition.
    Type: Application
    Filed: January 11, 2013
    Publication date: April 30, 2015
    Inventor: Mitsuya Shimoda
  • Patent number: 9017919
    Abstract: A resist composition containing a base component (A) which exhibits changed solubility in a developing solution under the action of acid, and an acid generator component (B) which generates acid upon exposure, wherein the acid generator component (B) includes an acid generator (B1) having a group represented by general formula (b1-1) shown below in the cation moiety.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: April 28, 2015
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Yoshiyuki Utsumi, Akiya Kawaue, Yoshitaka Komuro, Kenichiro Miyashita
  • Publication number: 20140303385
    Abstract: The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound comprising a conjugated-bond system under conditions such that the compounds undergo an asymmetric 1,4- or 1,6-conjugate addition reaction, generating a chiral compound in a stereoisomeric excess. The reaction is performed in the presence of a metal catalyst, which catalyst preferably comprises a non-racemic chiral ligand.
    Type: Application
    Filed: October 12, 2012
    Publication date: October 9, 2014
    Applicant: Isis Innovation Limited
    Inventors: Stephen P. Fletcher, Rebecca M. Maksymowicz, Philippe M.C. Roth
  • Patent number: 8802870
    Abstract: A method for converting trans-cis nepetalactone to cis-trans nepetalactone using molecular sieves. The molecular sieves may, for example, have a pH in water of at least about 9, and/or may be activated prior to use by heating.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: August 12, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Yamaira Gonzalez, David Richard Corbin
  • Publication number: 20140094618
    Abstract: Described is a method to make liquid chemicals. The method includes deconstructing cellulose to yield a product mixture comprising levulinic acid and formic acid, converting the levulinic acid to ?-valerolactone, and converting the ?-valerolactone to pentanoic acid. Alternatively, the ?-valerolactone can be converted to a mixture of n-butenes. The pentanoic acid can be decarboxylated yield 1-butene or ketonized to yield 5-nonanone. The 5-nonanone can be hydrodeoxygenated to yield nonane, or 5-nonanone can be reduced to yield 5-nonanol. The 5-nonanol can be dehydrated to yield nonene, which can be dimerized to yield a mixture of C9 and C18 olefins, which can be hydrogenated to yield a mixture of alkanes.
    Type: Application
    Filed: December 2, 2013
    Publication date: April 3, 2014
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: James A. Dumesic, Juan Carlos Serrano Ruiz, Ryan M. West
  • Patent number: 8623912
    Abstract: Novel Fostriecin (or FST) derivatives represented by formula (I), the pharmaceutical compositions and preparation methods thereof. The pharmaceutical uses of these compounds, especially the use for the preparation of pharmaceutical compositions for treating tumor, inhibiting cell over growth, or lowering myocardial infarction and the injury to cells.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: January 7, 2014
    Assignees: Beijing Biostar Technologies, Ltd., Dalian University of Technology
    Inventors: Li Tang, Rongguo Qiu
  • Patent number: 8609172
    Abstract: A method of using organic compounds and providing slow release flavoring in or for food products wherein flavor precursors are added to flavor compositions and/or food products and release flavor compounds upon consumption of the food products, and novel flavor precursor compounds. The flavor precursors can be prepared from mono- and/or diglycerides and lactone flavor compounds.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 17, 2013
    Assignee: Givaudan SA
    Inventor: Willi Grab
  • Patent number: 8598303
    Abstract: The invention provides a process for the preparation of valerolactone, said process comprising reacting levulinic acid with hydrogen by using a solid Ru catalyst, characterized in that the process is carried out in the presence of at least 0.08% (w/w) water relative to the amount of levulinic acid. Said process may be faster and more selective. This process advantageously allows the production of valerolactone from renewable sources. The valerolactone may be used in the preparation of methylpentenoate, adipic acid dimethylester, adipic acid, hexamethylenediamine, and polyamide 6,6 (all claimed).
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: December 3, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Anna Maria Cornelia Francisca Castelijns, Michele Catherine Christianne Janssen, Henricus Wilhemus Leonardus Marie Vaessen
  • Patent number: 8569362
    Abstract: The present invention relates to a polyketide molecule of the following formula (I): or a pharmaceutically acceptable salt thereof, where R1 is a hydrogen atom or a (C1-C7) alkyl group, as well as the method of preparation and use thereof, in particular as an anticancer agent.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: October 29, 2013
    Assignees: Pierre Fabre Medicament, Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Development (IRD)
    Inventors: Isabelle Carletti, Georges Massiot, Cécile Debitus
  • Publication number: 20130217898
    Abstract: The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ?-caprolactone was obtained at an isolated yield of 82%.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 22, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Kazuaki Ishihara, Muhammet Uyanik
  • Patent number: 8466299
    Abstract: The process relates to a process for preparing delta-valerolactone (VLO) in the gas phase by catalytic dehydrogenation over at least two different catalysts.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: June 18, 2013
    Assignee: BASF SE
    Inventors: Rolf Pinkos, Christophe Bauduin, Axel Paul, Gerhard Fritz, Hans Wagner
  • Patent number: 8420833
    Abstract: The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: April 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L Fortman, Jay D Keasling
  • Publication number: 20120329981
    Abstract: The invention provides a process for the preparation of valerolactone, said process comprising reacting levulinic acid with hydrogen by using a solid Ru catalyst, characterised in that the process is carried out in the presence of at least 0.08% (w/w) water relative to the amount of levulinic acid. Said process may be faster and more selective. This process advantageously allows the production of valerolactone from renewable sources. The valerolactone may be used in the preparation of methylpentenoate, adipic acid dimethylester, adipic acid, hexamethylenediamine, and polyamide 6,6 (all claimed).
    Type: Application
    Filed: June 20, 2012
    Publication date: December 27, 2012
    Applicant: DSM IP ASSETS B.V.
    Inventors: Anna Maria Cornelia Francisca Castelijns, Michele Catherine Christianne Janssen, Henricus Wilhemus Leonardus Marie Vaessen
  • Publication number: 20120315681
    Abstract: The patent application relates to a method of producing a monomer component from a genetically modified polyhydroxyalkanoate (PHA) biomass, wherein the biomass is heated in the presence of a catalyst to release a monomer component from the PHA.
    Type: Application
    Filed: February 11, 2011
    Publication date: December 13, 2012
    Inventors: Johan van Walsem, Erik Anderson, John Licata, Kevin A. Sparks, Christopher Mirley, M.S. Sivasubramanian
  • Publication number: 20120156255
    Abstract: A polymeric matrix for delivery of an HMG CoA reductase inhibitor such as a statin to tissue such as cardiac tissue in need thereof for the treatment or prevention of a disease or defect such as atrial fibrillation has been developed. In the preferred embodiment, a statin is delivered by means of a patch sutured to cardiac tissue at the time of cardiothoracic surgery. In the most preferred embodiment, the patch is a biodegradable material providing controlled or sustained release over a prolonged period of time, such as a week. Suitable materials include extracellular matrix, or other biodegradable hydrogels or polymeric materials providing sustained or controlled release of statin at the site of application.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Inventors: Jaipal Singh, Nicolas Chronos
  • Publication number: 20110237806
    Abstract: The process relates to a process for preparing delta-valerolactone (VLO) in the gas phase by catalytic dehydrogenation over at least two different catalysts.
    Type: Application
    Filed: December 2, 2009
    Publication date: September 29, 2011
    Applicant: BASF SE
    Inventors: Rolf Pinkos, Christophe Bauduin, Axel Paul, Gerhard Fritz, Hans Wagner
  • Publication number: 20110082200
    Abstract: Compositions containing 5,6,7-trihydroxyheptanoic acid and analogs and their use for treating posterior segment ocular diseases and diseases characterized by cellular hyperproliferation or angiogenesis, are disclosed.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 7, 2011
    Applicant: ALCON, INC.
    Inventors: Peter G. KLIMKO, Mark R. HELLBERG, David P. BINGAMAN, Daviel A. GAMACHE
  • Publication number: 20110021790
    Abstract: The present invention provides for a non-naturally occurring polyketide synthase (PKS) capable of synthesizing a carboxylic acid or a lactone, and a composition such that a carboxylic acid or lactone is included. The carboxylic acid or lactone, or derivative thereof, is useful as a biofuel. The present invention also provides for a recombinant nucleic acid or vector that encodes such a PKS, and host cells which also have such a recombinant nucleic acid or vector. The present invention also provides for a method of producing such carboxylic acids or lactones using such a PKS.
    Type: Application
    Filed: April 29, 2009
    Publication date: January 27, 2011
    Applicant: The Regents of the University of California
    Inventors: Leonard Katz, Jeffrey L. Fortman, Jay D. Keasling
  • Patent number: 7875327
    Abstract: A nematic liquid crystal compound represented by any one of formulas (a-1) to (a-6): in formulas (a-1) to (a-6), Ra and Rb are each independently hydrogen or alkyl having 1 to 10 carbons, provided that in the alkyl, —CH2- may be replaced by —O—, —(CH2)2- may be replaced by —CH?CH—, and hydrogen may be replaced by a halogen; ring A1 and ring A2 are each independently trans-1,4-cyclohexylene or 1,4-phenylene, provided that in these rings hydrogen may be replaced by a halogen, and in the case where the ring is trans-1,4-cyclohexylene, —CH2- may be replaced by —O—, and —CH2CH— may be replaced by —CH?C—; and Z1 and Z2 are each independently a single bond, —COO—, —OCO—, —OCH2-, —CH2O— or —CH2CH2-, provided that in formula (a-3), in the case where ring A2 is trans-1,4-cyclohexylene, Z2 is a single bond, —COO—, —OCO—, —OCH2- or —CH2O—, in the case where Ra is —C3H7, Rb is —OC2H5, and Z2 is a single bond, ring A2 is trans-1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 2-fluoro- 1,4-phenylene, 3-fluoro-1,4-phenylene, 2-f
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: January 25, 2011
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventors: Mayumi Goto, Teruyo Sugiura, Norikatsu Hattori
  • Publication number: 20100305339
    Abstract: The present invention provides a process for preparing lactones from optionally substituted, saturated aliphatic diols having from five to 20 carbon atoms between the two ring-closing hydroxyl groups by catalytic dehydrogenation and cyclization in the liquid phase over at least one catalyst.
    Type: Application
    Filed: October 12, 2007
    Publication date: December 2, 2010
    Applicant: BASF SE
    Inventors: Rolf Pinkos, Daniel Breuninger
  • Publication number: 20100266717
    Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.
    Type: Application
    Filed: April 20, 2010
    Publication date: October 21, 2010
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Ratnakar Asolkar, Sarahann Dow, Huazhang Huang, Marja Koivunen, Pamela Marrone, Stephanie Shu
  • Publication number: 20100216072
    Abstract: A positive photosensitive composition ensuring wide exposure latitude and reduced line edge roughness not only in normal exposure (dry exposure) but also in immersion exposure, a pattern forming method using the positive photosensitive composition, and a novel resin contained in the positive photosensitive composition are provided, which are a positive photosensitive composition comprising (A) a resin having a specific lactone structure in the side chain and being capable of increasing the solubility in an alkali developer by the action of an acid and (B) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, a pattern forming method using the positive photosensitive composition, and a novel resin contained in the positive photosensitive composition.
    Type: Application
    Filed: September 11, 2008
    Publication date: August 26, 2010
    Applicant: FUJIFILM CORPORATION
    Inventors: Yuko Tada, Kazuto Shimada, Shuji Hirano
  • Patent number: 7741344
    Abstract: A process for resolution of racemic BEL into its individual enantiomeric constituents by chiral HPLC. A method for determining the role of specific isoforms of iPLA2 in biologic processes.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: June 22, 2010
    Assignee: Washington University in St. Louis
    Inventor: Richard W. Gross
  • Publication number: 20100130754
    Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with bidentate ligands, having one amino or imino coordinating group and one phosphino coordinating group, in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 27, 2010
    Inventors: Lionel Saudan, Philippe Dupau, Jean-Jacques Riedhauser, Patrick Wyss
  • Publication number: 20100113460
    Abstract: Disclosed are compounds having the ability to inhibit cytochrome P450 2A6, 2A13, and/or 2B6 and tobacco products comprising them. Also disclosed are pharmaceutical compositions comprising them.
    Type: Application
    Filed: March 20, 2008
    Publication date: May 6, 2010
    Applicant: Givaudan SA
    Inventors: Boris Schilling, Wolf D. Woggon, Antoinette Chougnet, Thierry Granier, Georg Frater, Andreas Hanhart
  • Patent number: 7678778
    Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: March 16, 2010
    Assignee: DEKK-TEC, Inc.
    Inventor: Lee Roy Morgan
  • Patent number: 7642363
    Abstract: The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula 1, where X stands for a leaving group, and R1, R2, and R3 each independently stand for an alkyl group with 1-3 carbon atoms from 4-hydroxy-6-X-substituted-methyl-tetrahydropyran-2-one compounds, where X is as defined above, with the aid of an acetalization agent, in the presence of an acid catalyst. The invention also relates to the novel compounds of formula 1 as well as salts and acids to be prepared from these, with the OR3 group in formula 1 being replaced by an OY group, where X, R1 and R2 have the meanings defined above and where Y stands for an alkaline (earth) metal or a substituted or unsubstituted ammonium group or stands for hydrogen, and to the novel compounds of formula 2. The products concerned are, after conversion into the t-butyl ester of 2-(6-hydroxymethyl-1,3-dioxane-4-yl)acetic acid, important as intermediary products in the preparation of statins.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: January 5, 2010
    Assignee: AstraZeneca UK Ltd.
    Inventors: Jacob Hermanus Mattheus Hero Kooistra, Hubertus Josephus Marie Zeegers, Daniel Mink, Joannes Maria Cornelis Antonius Mulders
  • Publication number: 20090305239
    Abstract: A method of determining a level of biologically active PON enzyme is provided. The method comprising determining lactonase activity of the PON enzyme, the lactonase activity being indicative of the level of biologically active PON enzyme. Also provided are novel compounds which may be used for measuring a lactonase activity of an enzyme.
    Type: Application
    Filed: August 14, 2006
    Publication date: December 10, 2009
    Inventors: Dan S. Tawfik, Olga Khersonsky
  • Patent number: 7622498
    Abstract: Pesticidal compounds of general formula (I) Wherein ?represents a double bond; A— represents ?C(R5)—C(?O)—, wherein R represents hydrogen or halogen, R1 and R2 represent, independently, hydrogen, halogen, alkoxy, substituted alkoxy or an ester group; or R1 and R2, together with the carbon atoms to which they are attached, represent an oxirane ring; or R1 and R2, taken together, represent an alkylidenedioxy or substituted alkylidenedioxy group; and R3 represents —CH2R6, wherein R6 represents an ester group, oxiranyl, or a group of formula wherein R7 represents hydrogen or alkyl, R8 represents phenylsulfanyl, phenylselenyl, phenylsulfoxy or phenylselenoxy, and R9 represents hydrogen, ethoxycarbonyl or carbamoyl and R4 represents, independently, hydrogen, alkoxy or substituted alkoxy; and methods of making the compounds of formula (I) and methods for controlling pests wherein the pest dies as a result of contact with a compound of formula (I).
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: November 24, 2009
    Assignees: Instituto Politecnico de Santarem/Escoal Superior Agraria, Faculdade de Ciencias da Universidade de Lisboa, University of Newcastle
    Inventors: Jorge Alberto Guerra Justino, Amelia Pilar Grases Santos Silva Rauter, Tana Lukeba Canda, Richard Wilkins
  • Patent number: 7618688
    Abstract: A nematic liquid crystal compound represented by any one of formulas (a-1) to (a-6): in formulas (a-1) to (a-6), Ra and Rb are each independently hydrogen or alkyl having 1 to 10 carbons, provided that in the alkyl, —CH2- may be replaced by —O—, —(CH2)2- may be replaced by —CH?CH—, and hydrogen may be replaced by a halogen; ring A1 and ring A2 are each independently trans-1,4-cyclohexylene or 1,4-phenylene, provided that in these rings hydrogen may be replaced by a halogen, and in the case where the ring is trans-1,4-cyclohexylene, —CH2- may be replaced by —O—, and —CH2CH— may be replaced by —CH?C—; and Z1 and Z2 are each independently a single bond, —COO—, —OCO—, —OCH2-, —CH2O— or —CH2CH2-, provided that in formula (a-3), in the case where ring A2 is trans-1,4-cyclohexylene, Z2 is a single bond, —COO—, —OCO—, —OCH2- or —CH2O—, in the case where Ra is —C3H7, Rb is —OC2H5, and Z2 is a single bond, ring A2 is trans-1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 2-fluoro-1,4-phenylene, 3-fluoro-1,4-phenylene, 2-fl
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: November 17, 2009
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventors: Mayumi Goto, Teruyo Sugiura, Norikatsu Hattori
  • Patent number: 7615231
    Abstract: The present invention provides inexpensive, safe and reliable methods for improving the morphology, tone, texture and/or appearance of the skin and/or hair of a mammal, preferably without using one or more surfactants (or other chemicals) that can strip away, or otherwise remove, one or more protective lipids from the skin and/or hair. These methods comprise topically applying to the skin and/or hair at least three applications on a regular basis of a composition in an effective amount including: (a) a Meadowlactone in an amount that is effective for enhancing the morphology, tone, texture and/or appearance of the skin and/or hair, and having the chemical structure set forth herein; and (b) a cosmetically acceptable base in an amount that is effective for acting as a carrier vehicle for the Meadowlactone.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: November 10, 2009
    Assignee: Fan Tech, Ltd.
    Inventor: Alan Wohlman
  • Publication number: 20090263552
    Abstract: A method of using organic compounds and providing slow release flavoring in or for food products wherein flavor precursors are added to flavor compositions and/or food products and release flavor compounds upon consumption of the food products, and novel flavor precursor compounds. The flavor precursors can be prepared from mono- and/or diglycerides and lactone flavor compounds.
    Type: Application
    Filed: July 25, 2007
    Publication date: October 22, 2009
    Inventor: Willi Grab
  • Publication number: 20090198065
    Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.
    Type: Application
    Filed: March 26, 2009
    Publication date: August 6, 2009
    Applicant: Mitsubishi Rayon Co., Ltd.
    Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
  • Patent number: 7528268
    Abstract: The present invention relates to a process for the oxidation, in an inert solvent, of a non-aromatic or non-enonic ethylenic bond or of a non-conjugated cyclic ketones into the corresponding epoxides, respectively lactone, using H2O2 as oxidant, a content in water of the reaction medium below 15% w/w and, as sole catalyst, an alkaline or alkaline earth salt or complex.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: May 5, 2009
    Assignee: Firmenich SA
    Inventor: Hubert Mimoun
  • Patent number: 7491833
    Abstract: A valerolactone compound represented by the formula (I): wherein each of R1 and R2 is independently a hydrogen atom, a methyl group or an ethyl group wherein when R1 is a hydrogen atom, R2 is not a hydrogen atom; and wherein when R2 is a hydrogen atom, R1 is not a hydrogen atom, R3 is a hydrogen atom or a methyl group, and R4 is a propyl group, a 1-propenyl group or a phenyl group; a valerolactone compound represented by the formula (II): a process for preparing the same; and a perfume composition comprising the above-mentioned valerolactone compound.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: February 17, 2009
    Assignee: Kao Corporation
    Inventors: Sakuya Tanaka, Kazuyuki Fukuda, Takahiro Asada
  • Patent number: 7473790
    Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: January 6, 2009
    Assignee: Pfizer Inc.
    Inventors: Allen Borchardt, Javier Gonzalez, Hui Li, Maria Angelica Linton, John Howard Tatlock
  • Publication number: 20080269508
    Abstract: A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), wherein R is, and wherein R1 and R2 are methyl and R3 is hydrogen or methyl, comprising the steps of, heating a compound of formula (II), wherein R is as defined before, and R4 is hydrogen, NH4+ or an alkali metal, in a solvent mixture consisting of an aromatic hydrocarbon and a ketone in an inert atmosphere at a temperature of between 60° C. to 92° C. in the absence or presence of orthophosphoric acid or its alkali dihydrogen salts or alkali hydrogen salts of a dibasic acid, followed by optional neutralization of the reaction mixture with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization. The process leads to formation of derivatives of formula I in high purity with dimmer impurity (III) less than 0.1% and anhydro impurity (IV) below 0.15%.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 30, 2008
    Inventors: Milind Moreshwar Gharpure, Swapnil Panditrao Sonawane, Srihari Shivaji Mane, Rajendra Dagesing Mahale
  • Patent number: 7341818
    Abstract: The disclosed invention relates to novel norborne-type monomers containing pendent lactone or sultone groups. The invention also relates to norborne-type polymers and copolymers containing pendent lactone or sultone groups. These polymers and copolymers are useful in making photoimagable materials. The photoimagable materials are particularly suitable for use in photoresist compositions useful in 193 and 157 nm photolithography.
    Type: Grant
    Filed: January 10, 2005
    Date of Patent: March 11, 2008
    Assignee: Promerus LLC
    Inventors: Xiaoming Wu, Larry F. Rhodes, Lawrence Seger
  • Patent number: 7314942
    Abstract: Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: January 1, 2008
    Assignee: E. I. duPont de Nemours & Co.
    Inventors: Keith W. Hutchenson, Leo E. Manzer
  • Patent number: 7230125
    Abstract: Methods of performing cycloadditions are described that include (a) combining a first reactant and a second reactant in a hydrogen bonding solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form a cycloadduct. Methods of performing asymmetric catalytic reactions are also described that include (a) combining a first reactant, a second reactant, and a catalytic amount of a chiral hydrogen-bond donor in a solvent to form a reaction mixture; and (b) reacting the first reactant and the second reactant to form an enantiomeric excess of a reaction product. Reaction mixtures corresponding to these methods are also described.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: June 12, 2007
    Assignee: The University of Chicago
    Inventors: Viresh H. Rawal, Yong Huang, Aditya K. Unni, Avinash N. Thadani
  • Patent number: 7214708
    Abstract: Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A where RA through RE and XA are as defined herein.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: May 8, 2007
    Assignee: Kosan Biosciences Incorporated
    Inventors: Kurt F. Sundermann, Simon James Shaw, Daniel V. Santi
  • Patent number: 7192982
    Abstract: Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: March 20, 2007
    Assignees: Ligand Pharmaceuticals, Inc., Eli Lilly and Company
    Inventors: Dawn Alisa Brooks, Alan M. Warshawsky, Chahrzad Montrose-Rafezadeh, Anne-Reifel Miller, Lourdes Prieto, Isabel Rojo, Jose Alfredo Martin, Maria Rosario Gonzales Garcia, Alicia Torrado, Rafael Ferritto Crespo, Carlos Lamas-Peteira, Robert J. Ardecky, Maria Martin-Ortega Finger
  • Patent number: 7183421
    Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 27, 2007
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Hideo Tanaka, Yutaka Kameyama
  • Patent number: 7141602
    Abstract: Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicillium genus, Streptomyces, Actinomadura, Micromonospora, some are obtained by treating the fermentation products using the method of chemical synthesis or they are the products of total chemical synthesis. The purity of the active ingredient is an important factor for manufacturing the safe and effective pharmaceutical, especially if the pharmaceutical product must be taken on a longer term basis in the treatment or prevention of high plasma cholesterol. The accumulation of the impurities from the pharmaceuticals of lower purity may cause many side effects during the medical treatment.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 28, 2006
    Assignee: LEK Pharmaceuticals d.d.
    Inventors: Rok Grahek, Dusan Milivojevic, Andrej Bastarda
  • Patent number: 7101654
    Abstract: The disclosed invention relates to novel norbornene-type monomers containing pendent lactone or sultone groups. The invention also relates to norbornene-type polymers and copolymers comprising one or more repeating units represented by the formula: and containing pendent lactone or sultone groups. These polymers and copolymers are useful in making photoimagable materials. The photoimagable materials are particularly suitable for use in photoresist compositions useful in 193 and 157 nm photolithography.
    Type: Grant
    Filed: January 14, 2004
    Date of Patent: September 5, 2006
    Assignee: Promerus LLC
    Inventors: Xiaoming Wu, Larry F. Rhodes, Lawrence Seger