At Least Two Additional Chalcogens Bonded Directly To The Tetracyclo Ring System Patents (Class 549/278)
  • Publication number: 20140243404
    Abstract: This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
    Type: Application
    Filed: September 13, 2011
    Publication date: August 28, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Scott Alan Snyder, Daniel S. Treitler, Alexandria P. Brucks, Andreas Gollner, Maria I. Chiriac, Nathan E. Wright, Jason J. Pflueger, Steven P. Breazzano
  • Publication number: 20140187799
    Abstract: Improved processes for the extraction of quassinoids such as quassin and neoquassin from natural substances containing these compounds are described. The process uses compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration. In a first embodiment, the process includes a sonication method using water and no organic solvent. The process is highly efficient and comprises fewer steps than other processes known in the art. In a second embodiment, a method of extracting quassinoids from natural substance comprising bark of a plant of the plant family Simaroubaceae is also disclosed. In a third embodiment, indirect sonication of quassinoids is described using a mixture of polar and non-polar organic solvents.
    Type: Application
    Filed: July 31, 2013
    Publication date: July 3, 2014
    Applicant: UNIVERSITY OF THE WEST INDIES
    Inventors: Trevor Herbert YEE, Helen Marjorie JACOBS
  • Patent number: 8710247
    Abstract: A means for the extraction and crystallization of quassinoids such as quassin and neoquassin from natural sources containing these compounds, using compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration is provided. In particular, a means for extraction that does not require use of lead acetate, chloroform, methanol, or diethyl ether is provided. The process includes a means of removing non-polar and very polar substances from an extracted residue to enhance crystallization of quassinoids from the residue.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: April 29, 2014
    Assignee: The University of the West Indies
    Inventors: Trevor Herbert Yee, Helen Marjorie Jacobs
  • Publication number: 20130344174
    Abstract: The present invention discloses the utility of factions and compounds from Polygonum chinense Linn in anti-diarrhea. The invention also includes their preparation and application method for anti-diarrhea treatment.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 26, 2013
    Applicant: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang BIAN, Haitao XIAO, Shilin CHEN, Dajian YANG, Hongxi XU, Aiping LU, Albert Sun-Chi CHAN
  • Patent number: 8568794
    Abstract: Pharmaceutical or dermo-cosmetic compositions for topical and intravaginal application for treatment of human and veterinary affections caused by anaerobic organisms or parasites are provided comprising quassinoids or plant extracts containing these phytochemicals, in effective amounts. Such compositions can be administered topically or intravaginally to patients in need thereof in various pharmaceutical dosage forms.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: October 29, 2013
    Assignee: Life Science Investments, Ltd.
    Inventors: Christian Diehl, Silvia Chami De Diehl
  • Patent number: 8519163
    Abstract: A novel chemical moiety triterpenoid AECHL-1 isolated from root bark of Ailanthus excelsa having the structure:
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: August 27, 2013
    Assignees: National Centre for Cell Science, Department of Biotechnology
    Inventors: Sandhya Sitasawad, Manish Lavhale, Santosh Kumar, Shrihari Mishra
  • Publication number: 20130112218
    Abstract: The invention relates to the use of one or more compounds selected from ellagic acid, ethers thereof, ellagic acid salts and ellagic acid ether salts, as an anti-dandruff agent; and to a cosmetic treatment method associated with such a use.
    Type: Application
    Filed: March 1, 2011
    Publication date: May 9, 2013
    Inventor: Tiphaine Derkx
  • Publication number: 20130035304
    Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 31, 2011
    Publication date: February 7, 2013
    Inventors: Loren D. Walensky, Michelle L. Stewart, Nicole Cohen
  • Publication number: 20130012726
    Abstract: A means for the extraction and crystallization of quassinoids such as quassin and neoquassin from natural sources containing these compounds, using compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration is provided. In particular, a means for extraction that does not require use of lead acetate, chloroform, methanol, or diethyl ether is provided. The process includes a means of removing non-polar and very polar substances from an extracted residue to enhance crystallization of quassinoids from the residue.
    Type: Application
    Filed: July 10, 2012
    Publication date: January 10, 2013
    Inventors: Trevor Herbert YEE, Helen Marjorie JACOBS
  • Patent number: 8299275
    Abstract: Catalytic processes for the production of carnosol from carnosic acid using hydrogen peroxide or a peracid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron salts, a minor amount of water, rosemary needles, or a mixture thereof.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: October 30, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Andreas Kleefeldt, Christof Wehrli
  • Patent number: 8299274
    Abstract: Novel catalytic processes for the production of carnosol from carnosic acid using hydrogen peroxide or a peracid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron salts, a minor amount of water, rosemary needles, or a mixture thereof.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: October 30, 2012
    Assignee: DSM IP Assets B.V.
    Inventor: Christof Wehrli
  • Patent number: 8227508
    Abstract: The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
    Type: Grant
    Filed: November 22, 2007
    Date of Patent: July 24, 2012
    Assignees: DSM IP Assets B.V., Nestec S.A.
    Inventors: Ann Fowler, Regina Goralczyk, Claus Kilpert, Hasan Mohajeri, Daniel Raederstorff, Antoine De Saizieu, Goede Schueler, Ying Wang-Schmidt, Christof Wehrli
  • Patent number: 8217187
    Abstract: A means for the extraction and crystallization of quassinoids such as quassin and neoquassin from natural sources containing these compounds, using compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration is provided. In particular, a means for extraction that does not require use of lead acetate, chloroform, methanol, or diethyl ether is provided. The process includes a means of removing non-polar and very polar substances from an extracted residue to enhance crystallization of quassinoids from the residue.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: July 10, 2012
    Assignee: The University of the West Indies
    Inventors: Trevor Herbert Yee, Helen Marjorie Jacobs
  • Publication number: 20120164243
    Abstract: Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.
    Type: Application
    Filed: December 23, 2011
    Publication date: June 28, 2012
    Applicant: Amazentis SA
    Inventors: Christopher L. Rinsch, William Blanco-Bose, Bernard Schneider, Charles Thomas, Carmen Sandi, Johan Auwerx, Penelope Andreux, Richardus Houtkooper, Eija Pirinen, Laurent Mouchiroud, David Genoux
  • Publication number: 20110295021
    Abstract: Carnosol can be crystallized from a plant extract by contacting the extract with acetic acid, and collecting the crystals so formed.
    Type: Application
    Filed: September 15, 2009
    Publication date: December 1, 2011
    Inventor: Christof Wehrli
  • Publication number: 20110144357
    Abstract: Catalytic processes for the production of carnosol from carnosic acid using hydrogen peroxide or a peracid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron salts, a minor amount of water, rosemary needles, or a mixture thereof.
    Type: Application
    Filed: August 4, 2009
    Publication date: June 16, 2011
    Inventors: Andreas Kleefeldt, Christof Wehrli
  • Publication number: 20110144096
    Abstract: Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-membered rings and a substituted or unsubstituted C5 or C6 heteroaryl or hetero-cycloalkyl ring and pharmaceutically acceptable salts, prodrugs, and derivatives thereof. Specifically, methods and compounds for the treatment of disorders including neurologic, neuropsychiatric, and metabolic disorders are provided. For example, a method is provided of treating or reducing the risk of depression, anxiety, or obesity in a subject, which includes selecting a subject with or at risk of developing depression, anxiety, or obesity, and administering to the subject a therapeutically effective amount of the described compounds.
    Type: Application
    Filed: July 28, 2009
    Publication date: June 16, 2011
    Applicant: EMORY UNIVERSITY
    Inventor: Keqiang Ye
  • Publication number: 20110112181
    Abstract: Disclosed is a composition for modulating the release of a neurotransmitter, which includes naturally extracted polyphenols as an active ingredient. The disclosed composition suppresses the formation of a SNARE complex, thereby modulating the release of a neurotransmitter, and thus can be used as a modulator for a reaction within a cell related to the SNARE complex. Such an inhibitor of the SNARE complex formation can be used as a composition for reducing wrinkles and relieving pain.
    Type: Application
    Filed: March 12, 2008
    Publication date: May 12, 2011
    Applicant: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION
    Inventors: Dae-Hyuk Kweon, Yeon-Kyun Shin, Chang-Hwa Jung, Yoo-Soo Yang
  • Patent number: 7919636
    Abstract: Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: April 5, 2011
    Assignee: The Regents of the University of California
    Inventors: Navindra P. Seeram, David Heber
  • Publication number: 20110065662
    Abstract: Aspects of the invention relate to compounds, extracts and compositions thereof, and methods of using of the same, to treat neurodegenerative disorders and/or improve brain health. In certain embodiments, said compounds are pomegranate flavonoids.
    Type: Application
    Filed: July 23, 2010
    Publication date: March 17, 2011
    Applicant: Amazentis SA
    Inventors: Christopher L. Rinsch, Philippe V. L. Dupraz
  • Patent number: 7897791
    Abstract: Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: March 1, 2011
    Assignee: The Regents of the University of California
    Inventors: Navindra P. Seeram, David Heber
  • Publication number: 20110028416
    Abstract: Compositions and methods for maintenance of bone health or prevention, alleviation and/or treatment of bone disorders are presented. The present invention also provides the manufacture of a nutritional product, a supplement or a medicament for promoting bone growth or for the maintenance of bone health and methods regarding same. In an embodiment, the present invention provides a composition comprising an active ingredient having an effective amount of a plant or plant extract containing at least one phytochemical having the ability to induce bone morphogenic protein expression.
    Type: Application
    Filed: February 25, 2008
    Publication date: February 3, 2011
    Applicant: NESTEC S.A.
    Inventors: Elizabeth Offord Cavin, Gary Williamson, Didier Courtois, Bernard Lemaure, Andre Touche, Grace Ing Soon, Laurent Ameye
  • Publication number: 20100311987
    Abstract: A novel chemical moiety triterpenoid AECHL-1 isolated from root bark of Ailanthus excelsa having anti-cancer properties exhibiting remarkable activity in treatment of various forms of tumors with specificity wherein it blocks the growth of four tumor cell lines with distinct origins and of different p53 status (B16F10 mouse melanoma, PC3 human prostate cancer, MCF-7 and MDA-MB-231 human breast cancer), having following characteristic IR, NMR and mass spectra IR (KBr): 3425, 3419 (hydroxyl group), 2972, 2966, 2923, 2873 (alkyl C—H stretch), 1733 (? lactone), 1718 (Bi acetyl), 1680 (C?O conjugation with alkene), 1652 (—C?C stretching), 1600 (aromatic), 1492, 1454, 1394 (methyl stretching), 1222 (? lactone), 1184, 1110, 1051, 1031 (acetals), 1018 nm (alkanes). 1H-NMR (DMSO, 400 Hz) ?: 0.95 (3H, t, 4?-CH3), ?:1.15 (3H, d, H-24), ?:1.235 (3H, d, 5?-CH3), ?: 1.5 (2H, ddd, 5?-CH2), ?: 1.73 (3H, ddd, H-21), ?: 1.83 (1H, s, H-9), ?: 1.87 (1H, s, H-14), ?: 1.9 (2H, s, H-18), ?: 2.16 (3H, s, H-18), ?: 2.
    Type: Application
    Filed: December 2, 2008
    Publication date: December 9, 2010
    Applicants: National Centre For Cell Science, Department of Biotechnology
    Inventors: Sandhya Sitasawad, Manish Lavhale, Santosh Kumar, Shrihari Mishra
  • Publication number: 20100210859
    Abstract: Novel catalytic processes for the production of carnosol from carnosic acid using hydrogen peroxide or a peracid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron salts, a minor amount of water, rosemary needles, or a mixture thereof.
    Type: Application
    Filed: October 21, 2008
    Publication date: August 19, 2010
    Inventor: Christof Wehrli
  • Publication number: 20100048688
    Abstract: The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
    Type: Application
    Filed: November 22, 2007
    Publication date: February 25, 2010
    Applicants: DSM IP ASSETS B.V., NESTEC S.A.S.
    Inventors: Ann Fowler, Regina Goralczyk, Claus Kilpert, Hasan Mohajeri, Daniel Raederstorff, Antoine De Saizieu, Goede Schueler, Ying Wang-Schmidt, Christof Wehrli
  • Patent number: 7638640
    Abstract: Compositions of purified and biologically active ellagitannins are provided by separation from pomegranate husk using a method of extraction and purification using a solid polymeric adsorbent and the uses of the said compounds.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: December 29, 2009
    Assignee: The Regents of the University of California
    Inventors: Navindra P. Seeram, David Heber
  • Publication number: 20090171102
    Abstract: A means for the extraction and crystallization of quassinoids such as quassin and neoquassin from natural sources containing these compounds, using compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration is provided. In particular, a means for extraction that does not require use of lead acetate, chloroform, methanol, or diethyl ether is provided. The process includes a means of removing non-polar and very polar substances from an extracted residue to enhance crystallization of quassinoids from the residue.
    Type: Application
    Filed: July 29, 2008
    Publication date: July 2, 2009
    Inventors: Trevor Herbert Yee, Helen Marjorie Jacobs
  • Patent number: 7153946
    Abstract: A molecular conjugate is provided having the formula: wherein R1 is a de-hydroxyl or de-amino moiety respectively of a hydroxyl-bearing or amino-bearing biologically active molecule or an analog or derivative thereof, and Z is —O— or —NH—, respectively, Y is a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups; and R2 is —CH?CH(W), —CH(OH)CH(OH)W, or —C(O)H, where W can be H, a straight or branched alkyl having 1 to 20 carbons that may be optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl groups, electron-withdrawing groups, or electron-donating groups.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: December 26, 2006
    Assignee: Tapestry Pharmaceuticals, Inc.
    Inventors: James D. McChesney, Madhavi C. Chander, Teruna J. Siahaan, Christine R. Xu, Sterling K. Ainsworth
  • Publication number: 20020095046
    Abstract: Dibenzonaphthyrone of formula (I) 1
    Type: Application
    Filed: June 13, 2001
    Publication date: July 18, 2002
    Inventors: Peter Nesvadba, Joachim Jandke
  • Publication number: 20020086898
    Abstract: The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the present inventive method. The compounds and their derivatives may be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the growth or replication of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2.
    Type: Application
    Filed: June 22, 2001
    Publication date: July 4, 2002
    Inventors: Michael R. Boyd, John H. Cardellina, Kirk R. Gustafson, James B. McMahon, Richard W. Fuller, Gordon M. Cragg, Yoel Kashman, Doel Soejarto
  • Patent number: 6277879
    Abstract: Calanolide analogues that demonstrate potent antiviral activity against many viruses are provided. Also provided is a method of using calanolide analogues for treating or preventing viral infections. The calanolide analogues provided are obtained via syntheses employing chromene 4 and chromanone 7 as key intermediates.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: August 21, 2001
    Assignee: Sarawak Medichem Pharmaceuticals, Inc.
    Inventors: Ze-Qi Xu, Michael T. Flavin, David Zembower
  • Patent number: 6083978
    Abstract: A sulphamate compound suitable for use as an inhibitor of both oestrone sulphatase activity and aromatase activity. The compound can have the general formula (II) wherein F represents a phenolic ring structure (the first ring structure), J represents the third ring structure; I represents a phenolic ring structure (the second ring structure), G is an optional double bond, H is a link joining the second ring structure to the third ring structure, and Y represents a suitable second group; wherein any one of ring structures F, J and I has bound thereto a sulphamate group.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: July 4, 2000
    Assignee: Sterix Limited
    Inventors: Michael J. Reed, Barry V. Potter
  • Patent number: 6043271
    Abstract: A method of preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided. According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal or paraldehyde in the presence of an acid catalyst with heating, or a two-step reaction including an aldol reaction with acetaldehyde and cyclization either under acidic conditions or neutral Mitsunobu conditions, to produce chromanone 7. Reduction of chromanone 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A. A method for resolving (.+-.)-calanolide A into its optically active forms by a chiral HPLC system or by enzymatic acylation and hydrolysis is also disclosed. Finally, a method for treating or preventing a viral infections using (.+-.)-calanolide or (-)-calanolide is provided.
    Type: Grant
    Filed: August 2, 1995
    Date of Patent: March 28, 2000
    Assignee: Sarawak MediChem Pharmaceuticals, Inc.
    Inventors: Michael T. Flavin, Ze-Qi Xu, John D. Rizzo, Alla Kucherenko, Albert Khilevich, Abram Kivovich Sheinkman, Vilayphone Vilaychack, Lin Lin, Wei Chen, William A. Boulanger
  • Patent number: 6022497
    Abstract: Described are novel photochromic six-membered heterocyclic-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted six-membered heterocyclic group fused to one side of the naphtho portion of the naphthopyran and having certain substituents at the position ortho to the oxygen atom of the naphthopyran ring. These compounds may be represented by the following graphic formula: ##STR1## Also described are polymeric organic host materials that contain or that are coated with such compounds or combinations thereof with complementary photochromic compounds, e.g., certain other naphthopyrans, benzopyrans, and spiro(indoline) type compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: February 8, 2000
    Assignee: PPG Industries Ohio, Inc.
    Inventor: Anil Kumar
  • Patent number: 5892060
    Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: April 6, 1999
    Assignee: Sarawak MediChem Pharmaceuticals, Inc.
    Inventors: Michael T. Flavin, Ze-Qi Xu, Albert Khilevich, David Zembower, John D. Rizzo, Shuyuan Liao, Aye Mar, Lin Lin, Vilayphone Vilaychak, Darko Brankovic, Sergey Dzekhster, Jinjun Liu
  • Patent number: 5872264
    Abstract: A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (.+-.)-8a. Separation and enzyme-mediated resolution of (.+-.)-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (.+-.)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: February 16, 1999
    Assignee: Sarawak MediChem Pharmaceuticals, Inc.
    Inventors: Michael T. Flavin, Ze-Qi Xu, Albert Khilevich, David Zembower, John D. Rizzo, Shuyuan Liao, Aye Mar, Lin Lin, Vilayphone Vilaychack, Darko Brankovic, Sergey Dzekhster, Jinjun Liu
  • Patent number: 5608085
    Abstract: A method of synthesis of the four optically active stereoisomers of calanolide A and B which produces the compounds in high yields and in a high degree of purity.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: March 4, 1997
    Assignee: The University of Tennessee Research Corporation
    Inventors: David C. Baker, Prashant P. Deshtande, Shijia Yan, Frank Tagliaferri, Samuel F. Victory
  • Patent number: 5489697
    Abstract: A method for preparing (.+-.)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. Useful intermediates for preparing (.+-.)-calanolide A and its derivatives are also provided.According to the disclosed method, chromene 4 intermediate was reacted with acetaldehyde diethyl acetal in the presence of an acid catalyst with heating to produce chromanone 7. Reduction of chromene 7 with sodium borohydride, in the presence of cerium trichloride, produced (.+-.)-calanolide A, which was purified chromatographically.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: February 6, 1996
    Assignee: MediChem Research, Inc.
    Inventors: William A. Boulanger, Michael T. Flavin, Alla Kucherenko, Abram K. Sheynkman
  • Patent number: 5231193
    Abstract: A process for producing ellagic acid comprising reacting a tannin having gallic acid residues attached as constituents with an oxidizing agent at pH 7 or higher.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: July 27, 1993
    Assignee: Kikkoman Corporation
    Inventors: Kiyoshi Mizusawa, Yasuhiko Imai, Katsumi Yuasa, Hirokazu Koyama, Nobuyuki Yamaji, Shigehiro Kataoka, Tetsuya Oguma
  • Patent number: 5061695
    Abstract: An antitumor substance BE-12406 or a pharmaceutically acceptable salt thereof, which is represented by the general formula ##STR1## and a method of producing the novel substance.
    Type: Grant
    Filed: January 30, 1990
    Date of Patent: October 29, 1991
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Hiroyuki Suda, Katuhisa Kojiri, Akira Okura, Koutaro Funaishi, Kenji Kawamura, Masanori Okanishi
  • Patent number: 4665201
    Abstract: Novel antineoplastic ailanthone derivatives (IIb) represented by the following formula wherein R.sub.2 is C.sub.5 -C.sub.18 .alpha.,.beta.-unsaturated acyl group and its related compounds are disclosed. ##STR1## Particularly, some of the above compounds are far more effective than mitomycin C against mouse lymphocytic leucemia p388.These compounds can be synthesized from known ailanthone via important intermediates, triacyloxy ailanthone, represented by the formula: ##STR2## wherein R.sub.1 is acyl group.
    Type: Grant
    Filed: January 15, 1985
    Date of Patent: May 12, 1987
    Assignee: Suntory, Limited
    Inventors: Tadashi Honda, Kayoko Imao, Nobuo Nakatsuka, Toshihiro Nakanishi
  • Patent number: 4599409
    Abstract: The present invention relates to new bisamidine derivatives of polycyclic compounds such as 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrene-6(5H)-phenanthridone and 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrenephenanthridine and to a process for their preparation. The polycyclic bisamidines according to the invention are distinguished by valuable chemotherapeutic properties, such as, for example, an action against amoebas and trichomonads.
    Type: Grant
    Filed: February 15, 1984
    Date of Patent: July 8, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Balbir S. Bajwa, deceased, Dipak K. Chatterjee, Bimal N. Ganguli, Jurgen Reden, Noel J. de Souza
  • Patent number: 4476131
    Abstract: Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R.sub.1 is H or certain acyl groups; Q is CO.sub.2 R.sub.4, COR.sub.5, C(OR.sub.7)R.sub.5 R.sub.6, CN, CONR.sub.9 R.sub.10, CH.sub.2 NR.sub.9 R.sub.10, CH.sub.2 NHCOR.sub.11, CH.sub.2 NHSO.sub.2 R.sub.12, 5-tetrazolyl or when n is 1, Q and OR.sub.1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.
    Type: Grant
    Filed: March 16, 1982
    Date of Patent: October 9, 1984
    Assignee: Pfizer Inc.
    Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4414226
    Abstract: 1,4-naphthoquinone derivatives represented by the following general formula: ##STR1## (wherein R.sup.1 represents a hydrogen atom, a hydroxy group, a lower alkoxy group or an arylthio group, R.sup.2 represents a carboxy group, an esterified carboxy group or an amidated carboxy group or, when taken together, R.sup.1 and R.sup.2 form a group of ##STR2## R.sup.3 represents a hydrogen atom or a lower alkyl group, R.sup.4 represents a lower alkyl group, R.sup.5 represents a hydrogen atom or a halogen atom, and R.sup.6 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group), and the salts of the carboxy group thereof, which are novel compounds having an anticoccidium activity, and which can be obtained by synthesis or, partly, by cultivation of Streptomyces auranticolor.
    Type: Grant
    Filed: October 30, 1981
    Date of Patent: November 8, 1983
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Koichi Ikushima, Hirokazu Tanaka, Ohe Osamu, Eiko Kino, Masanobu Kohsaka, Hatsuo Aoki, Akira Arakawa, Hiroshi Imanaka
  • Patent number: 4360595
    Abstract: A polycyclic antitumor antibiotic designated herein as anandimycin is produced by fermentation of Streptomyces anandii subsp. araffinosus strain C-22,437 (ATCC 31431). Anandimycin possesses antibacterial activity and inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: November 23, 1982
    Assignee: Bristol-Myers Company
    Inventors: David M. Balitz, James A. Bush, Frances A. O'Herron, Donald E. Nettleton, Jr.