Bicyclo Ring System Having The Lactone Ring As One Of The Cyclos Patents (Class 549/283)
  • Patent number: 10211403
    Abstract: An organic photovoltaic device includes an anode and a cathode. The organic photovoltaic device includes an active layer between the anode and the cathode. The active layer includes a p-type material. The p-type material includes a donor-acceptor (DA) polymer. An acceptor unit of the DA polymer includes a functionalized pyranopyran-dione compound or a functionalized naphthyridine-dione compound.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: February 19, 2019
    Assignee: International Business Machines Corporation
    Inventors: Brandon M. Kobilka, Jason T. Wertz
  • Patent number: 9896456
    Abstract: This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against ACAT2.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: February 20, 2018
    Assignee: School Juridical Person Kitasato Institute
    Inventors: Hiroshi Tomoda, Masaki Ohtawa, Satoshi Omura, Tohru Nagamitsu
  • Patent number: 9688652
    Abstract: Disclosed are methods for treating catmint oil. The process allows the separation of sulfur-containing compounds from the catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: June 27, 2017
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Christopher Jackson, Leo Ernest Manzer, Henry Max Schleinitz, Mark A Scialdone, Keith W Hutchenson
  • Patent number: 9521844
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone, and from which formulated products may be prepared.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: December 20, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: John Charles Fisher, Keith W Hutchenson, Scott Christopher Jackson, Leo Ernest Manzer, Mark A Scialdone, Mayis Seapan
  • Publication number: 20150087698
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone, and from which formulated products may be prepared.
    Type: Application
    Filed: September 24, 2013
    Publication date: March 26, 2015
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: JOHN CHARLES FISHER, KEITH W. HUTCHENSON, SCOTT CHRISTOPHER JACKSON, LEO ERNEST MANZER, MARK A. SCIALDONE, MAYIS SEAPAN
  • Patent number: 8952182
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: February 10, 2015
    Assignee: E I du Pont de Nemours and Company
    Inventors: Scott Christopher Jackson, Leo Ernest Manzer, Henry Max Schleinitz, Mark A Scialdone, Keith W Hutchenson
  • Patent number: 8940184
    Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: January 27, 2015
    Assignee: MERCK PATENT GmbH
    Inventors: Andreas Taugerbeck, Achim Goetz
  • Patent number: 8871799
    Abstract: Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 28, 2014
    Assignee: Kineta, Inc.
    Inventors: Shawn P. Iadonato, Kristin Bedard
  • Publication number: 20140301975
    Abstract: Methods of treating blood disorders are described.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventor: Susan P. Perrine
  • Publication number: 20140296232
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Application
    Filed: March 27, 2014
    Publication date: October 2, 2014
    Applicants: Massachusetts General Hospital, The Broad Institute, Inc.
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • Patent number: 8815844
    Abstract: The present invention relates to the compounds useful in the prevention and/or treatment of tumors. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumors presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumor glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: August 26, 2014
    Assignees: Universite de Geneve, Hopitaux Universitaires de Geneve
    Inventors: Virginie Clement, Ivan Radovanovic
  • Patent number: 8802870
    Abstract: A method for converting trans-cis nepetalactone to cis-trans nepetalactone using molecular sieves. The molecular sieves may, for example, have a pH in water of at least about 9, and/or may be activated prior to use by heating.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: August 12, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Yamaira Gonzalez, David Richard Corbin
  • Patent number: 8765975
    Abstract: This invention provides a process for producing dihydronepetalactone using mixtures comprising both trans-cis nepetalactone and cis-trans nepetalactone. A reaction mixture comprising trans-cis nepetalactone and cis-trans nepetalactone is first contacted with hydrogen in the presence of at least one hydrogenation catalyst under conditions that optimise the preferential conversion of trans-cis nepetalactone to dihydronepetalactone. Cis-trans nepetalactone is subsequently converted to dihydronepetalactone by contact with hydrogen in the presence of at least one hydrogenation catalyst.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: July 1, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Keith W. Hutchenson, Scott Christopher Jackson, Leo Ernest Manzer, Mark A. Scialdone, Mayis Seapan
  • Patent number: 8697390
    Abstract: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI).
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: April 15, 2014
    Assignee: ChemoMetec A/S
    Inventors: Mette Elena Skindersø, Helle Frobøse Sørensen, Søren Kjaerulff
  • Patent number: 8680137
    Abstract: This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: March 25, 2014
    Assignee: Nono Inc.
    Inventors: Xiujun Sun, Michael Tymianski, Jonathan David Garman
  • Patent number: 8633325
    Abstract: Dihydronepetalactone, a minor natural constituent of the essential oil of catmints (Nepeta spp.) such as Nepeta cataria, has been identified as an effective insect repellent compound. Synthesis of dihydronepetalactone may be achieved by hydrogenation of nepetalactone, the major constituent of catmint essential oils. This compound, which also has fragrance properties, may be used commercially for its insect repellent properties, and methods for making an composition thereof are disclosed.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: January 21, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: David L. Hallahan, Leo Ernest Manzer
  • Publication number: 20140018551
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone.
    Type: Application
    Filed: September 24, 2013
    Publication date: January 16, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: SCOTT CHRISTOPHER JACKSON, LEO ERNEST MANZER, HENRY MAX SCHLEINITZ, MARK A. SCIALDONE, KEITH W. HUTCHENSON
  • Patent number: 8592007
    Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (polymer stabilized) or PSA (polymer sustained alignment) type.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: November 26, 2013
    Assignee: Merck Patent GmbH
    Inventors: Achim Goetz, Erdal Durmaz, Malgorzata Rillich, Andreas Taugerbeck
  • Publication number: 20130308081
    Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Application
    Filed: December 27, 2011
    Publication date: November 21, 2013
    Applicant: Merck Patent GmbH
    Inventors: Andreas Taugerbeck, Achim Goetz, Alexander Hahn, Martin Engel
  • Patent number: 8558015
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone, and from which formulated products may be prepared.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: October 15, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: John Charles Fisher, Keith W. Hutchenson, Scott Christopher Jackson, Leo Ernest Manzer, Mark A. Scialdone, Mayis Seapan
  • Patent number: 8552210
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: October 8, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Scott Christopher Jackson, Leo Ernest Manzer, Henry Max Schleinitz, Mark A. Scialdone, Keith W. Hutchenson
  • Publication number: 20130116247
    Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts there-of. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
    Type: Application
    Filed: April 5, 2011
    Publication date: May 9, 2013
    Applicant: MANNKIND CORPORATION
    Inventors: Qingping Zeng, Andras Toro, John Bruce Patterson, Warren Stanfield Wade, Zoltan Zubovics, Yun Yang, Zhipeng Wu
  • Publication number: 20130079394
    Abstract: This invention relates to novel coumarin derivatives, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents. This invention also relates to novel methods for modeling and/or predicting the repellency of unknown compounds.
    Type: Application
    Filed: September 21, 2012
    Publication date: March 28, 2013
    Applicants: CNRS (CENTRE NATIONAL RECHERCHE SCIENTIFIQUE), MERIAL LIMITED
    Inventors: Jean Delaveau, Pierre Nicolas Stebe, Nathalie Marchand-Geneste
  • Publication number: 20130026341
    Abstract: A photoelectric conversion material is provided and includes an organic material having an absorbing coefficient of about 1.5×105 (cm?1) or more and that is represented by the following formula (1). In the formula (1), each of R1 to R20, and each of X1 to X8 is one of a hydrogen atom and a substituent.
    Type: Application
    Filed: March 14, 2011
    Publication date: January 31, 2013
    Applicant: SONY CORPORATION
    Inventors: Masaki Murata, Ayumi Nihei
  • Publication number: 20120329832
    Abstract: This invention relates to novel coumarin derivative, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 27, 2012
    Inventors: Jean Delaveau, Emile Vialle, Marc Lemaire, Stephane Pellet-Rostaing, Bruno Andrioletti
  • Patent number: 8338401
    Abstract: The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: December 25, 2012
    Assignee: Institute of Materia Medica Chinese Academy of Medical Sciences
    Inventors: Shiping Xu, Xiaoguang Chen, Song Xu, Lanmin Li, Longfei Xie, Hongyan Li, Yan Li, Guifang Cheng
  • Patent number: 8309743
    Abstract: The present invention provides a compound having absorbing and luminescence wavelengths at relatively longer wavelength side of the visible area, and having thermal stability, which acts as a dye and/or a luminescence material and has practical utility therefor, and a production method thereof.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: November 13, 2012
    Assignee: The University of Tokyo
    Inventors: Hiroshi Nishihara, Mikihiro Hayashi, Fumiyuki Toshimitsu
  • Publication number: 20120259267
    Abstract: Compositions are provided in which dendrimers and/or nanoparticles are synthesized with multi-photon responsive elements and self-immolative oligomers. The compositions may be utilized to selectively deliver Payloads within tissue by irradiating the compositions. The compositions may also be used to amplify sensitivity to irradiation.
    Type: Application
    Filed: September 23, 2010
    Publication date: October 11, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Adah Almutairi, Nadezda Fomina, Jagadis Sankaranarayanan
  • Publication number: 20120214996
    Abstract: Dibenzylidene and heterobenzylideneacetone derivatives, related 4-piperidones, related 4-thiopyranones and the corresponding sulfinyl- and sulfonyl-analogues for their use for prophylaxis or treatment of trypanosomiasis and leishmaniasis.
    Type: Application
    Filed: September 20, 2010
    Publication date: August 23, 2012
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Elisabeth Davioud-Charvet, Ingrid Nicole Wenzel, Thomas J.J. Muller, Gilles Hanquet, Don Antoine Lanfranchi, Frederic Leroux, Thibault Gendron
  • Publication number: 20120208850
    Abstract: The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in vitro or in vivo. The invention also relates to sulfonate ester prodrugs of 1,3PDS as well as Gemini dimmers and oligomers of 1,3PDS for the prevention or treatment of associated diseases and conditions.
    Type: Application
    Filed: August 6, 2010
    Publication date: August 16, 2012
    Applicant: BELLUS HEALTH INC.
    Inventors: Xianqi Kong, Nigel Levens, Abderrahim Bouzide, Stephane Ciblat, Richard Frenette, Johanne Renaud
  • Publication number: 20120182516
    Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Application
    Filed: August 30, 2010
    Publication date: July 19, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Andreas Taugerbeck, Achim Goetz
  • Publication number: 20120108526
    Abstract: Antimicrobial compounds from Epicoccum purpurascens (syn. E. negrum) for use against plant and fungi pathogens. An orange yellow metabolite was isolated, the structure elucidated as a small group of compounds Epipyrone A-C and fungicidal activity demonstrated against plant pathogens, for example Botrytis cinerea and Lecanicillium muscarium. Agricultural and pharmaceutical compositions are provide, and use thereof in treating microbial infections in an animal or plant are also provided.
    Type: Application
    Filed: August 24, 2011
    Publication date: May 3, 2012
    Inventors: Roel van Ginkel, Andrew Ian Selwood, Alistair Lawrence Wilkins, Stephen Ford, Cody Calder
  • Publication number: 20110312013
    Abstract: The present invention provides simple, rapid methods and procedures for analyzing cells, hereunder quantitative and qualitative assessment of cells. The present invention relates to the use of N-(9-acridinyl)maleimide (NAM) or to the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species (e.g., sulphur-containing species) present in higher concentrations in intact (e.g., living) cells than in non-intact (e.g., dead) cells. The present invention also relates to the use of NAM or to the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI), particularly detectable upon its reaction with species present in intact and/or non-intact cells. Moreover, the present invention relates to the use of measuring techniques and/or instruments coupled with the use of NAM or with the use of 7-diethylamino-3-((4?-(iodoacetyl)amino)phenyl)-4-methylcoumarin (CPI).
    Type: Application
    Filed: July 14, 2009
    Publication date: December 22, 2011
    Applicant: CHEMOMETEC A/S
    Inventors: Mette Elena Skindersø, Helle Frobøse Sørensen, Søren Kjærulff
  • Patent number: 8067619
    Abstract: The present invention is directed to coumarin derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: November 29, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Nareshkumar F. Jain, Zhihua Sui
  • Publication number: 20110275707
    Abstract: Compounds of Formulas I are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
    Type: Application
    Filed: December 16, 2009
    Publication date: November 10, 2011
    Inventors: Kuo-Hsiung Lee, Yizhou Dong, Qian Shi, Kenneth F. Bastow, Pei-Chi Wu
  • Patent number: 8053585
    Abstract: The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing visible light, releases the organic moiety. Also disclosed is a method of making a photolabile compound that releases a biologically active compound upon absorbing visible light by providing an organic moiety and binding a coumarin family caging group to the organic moiety under conditions effective to make the photolabile compound. The present invention also relates to a method of obtaining a biologically active compound in a sample. The method involves adding to a sample a photolabile compound including a coumarin family caging group covalently bound to an organic moiety. The sample is then illuminated with visible light under conditions effective to obtain a biologically active compound including the organic moiety.
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: November 8, 2011
    Assignee: Cornell Research Foundation, Inc.
    Inventors: George P. Hess, Barry K. Carpenter, Vishakha R. Shembekar, Yongli Chen
  • Patent number: 8048889
    Abstract: The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: November 1, 2011
    Assignee: XTL Biopharmaceuticals Ltd.
    Inventors: Bin Xu, Qiang Zhu, Hyun-Joon Cho, Reza Fathi, Zhen Yang, Anthony Sandrasagra, Yixin Liu
  • Publication number: 20110251182
    Abstract: This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity.
    Type: Application
    Filed: December 13, 2010
    Publication date: October 13, 2011
    Applicant: NoNO, Inc.
    Inventors: Xiujun Sun, Michael Tymianski, Jonathan David Garman
  • Publication number: 20110205482
    Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (polymer stabilised) or PSA (polymer sustained alignment) type.
    Type: Application
    Filed: September 29, 2009
    Publication date: August 25, 2011
    Applicant: MERCH PATENT GESELLSCHAFT MIT BESCHRANKTE HAFTUNG
    Inventors: Achim Goetz, Erdal Durmaz, Malgorzata Rillich, Andreas Taugerbeck
  • Publication number: 20110077416
    Abstract: The present invention provides a compound having absorbing and luminescence wavelengths at relatively longer wavelength side of the visible area, and having thermal stability, which acts as a dye and/or a luminescence material and has practical utility therefor, and a production method thereof.
    Type: Application
    Filed: March 12, 2010
    Publication date: March 31, 2011
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Hiroshi Nishihara, Mikihiro Hayashi, Fumiyuki Toshimitsu
  • Patent number: 7833691
    Abstract: The present invention relates to a heterocycle-containing onium salt useful as, for example, a cationic photopolymerization initiator and an acid generator for a chemically amplified resist, and provides a heterocycle-containing onium salt shown in the specification.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: November 16, 2010
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Masami Ishihara, Yoji Urano, Masahiro Takahashi
  • Publication number: 20100267653
    Abstract: The invention provides coumarin compounds, in particular glycosidic coumarin compounds, useful in the treatment of dermatophyte fungal infections.
    Type: Application
    Filed: June 5, 2007
    Publication date: October 21, 2010
    Inventor: Colin Stewart
  • Patent number: 7815950
    Abstract: Ketomethionine ketals and hemiketals and derivatives thereof are useful as feed additives, in particular for the nutrition of ruminants.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: October 19, 2010
    Assignee: Evonik Degussa GmbH
    Inventors: Christoph Kobler, Martin Hateley, Philipp Roth, Barbara Jaeger, Rainer Peter, Christoph Weckbecker, Klaus Huthmacher
  • Publication number: 20100261915
    Abstract: A method for converting trans-cis nepetalactone to cis-trans nepetalactone using molecular sieves. The molecular sieves may, for example, have a pH in water of at least about 9, and/or may be activated prior to use by heating.
    Type: Application
    Filed: November 26, 2008
    Publication date: October 14, 2010
    Inventor: Yamaira Gonzalez
  • Publication number: 20100256142
    Abstract: A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
    Type: Application
    Filed: September 25, 2009
    Publication date: October 7, 2010
    Inventors: Jeffrey Aube, Bryan L. Roth, Partha Ghosh, Kevin J. Frankowski
  • Patent number: 7777056
    Abstract: A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), wherein R is, and wherein R1 and R2 are methyl and R3 is hydrogen or methyl, comprising the steps of, heating a compound of formula (II), wherein R is as defined before, and R4 is hydrogen, NH4+ or an alkali metal, in a solvent mixture consisting of an aromatic hydrocarbon and a ketone in an inert atmosphere at a temperature of between 60° C. to 92° C. in the absence or presence of orthophosphoric acid or its alkali dihydrogen salts or alkali hydrogen salts of a dibasic acid, followed by optional neutralization of the reaction mixture with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization. The process leads to formation of derivatives of formula I in high purity with dimmer impurity (III) less than 0.1% and anhydro impurity (IV) below 0.15%.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: August 17, 2010
    Assignee: Lupin Ltd.
    Inventors: Milind Moreshwar Gharpure, Swapnil Panditrao Sonawane, Srihari Shivaji Mane, Rajendra Dagesing Mahale
  • Publication number: 20100168447
    Abstract: This invention provides a process for producing dihydronepetalactone using mixtures comprising both trans-cis nepetalactone and cis-trans nepetalactone. A reaction mixture comprising trans-cis nepetalactone and cis-trans nepetalactone is first contacted with hydrogen in the presence of at least one hydrogenation catalyst under conditions that optimise the preferential conversion of trans-cis nepetalactone to dihydronepetalactone. Cis-trans nepetalactone is subsequently converted to dihydronepetalactone by contact with hydrogen in the presence of at least one hydrogenation catalyst.
    Type: Application
    Filed: December 20, 2007
    Publication date: July 1, 2010
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Keith W. Hutchenson, Ccott Christopher Jackson, Leo Ernest Manzer, Mark A. Scialdone, Mayis Seapan
  • Publication number: 20100145078
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone, and from which formulated products may be prepared.
    Type: Application
    Filed: December 20, 2007
    Publication date: June 10, 2010
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: John Charles Fisher, Keith W. Hutchenson, Scott Chirstopher Jackson, Leo Ernest Manzer, Mark A. Scialdone, Mayis Seapan
  • Publication number: 20100145077
    Abstract: Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the insect repellent, dihydronepetalactone.
    Type: Application
    Filed: December 20, 2007
    Publication date: June 10, 2010
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Christopher Jackson, Leo Ernest Manzer, Henry Max Schleinitz, Mark A. Scialdone
  • Publication number: 20100093955
    Abstract: The present invention relates to a photoreactive polymer that comprises a multi-cyclic compound in a main chain, and a polymerization method thereof. Since the photoreactive polymer according to the present invention comprises a multi-cyclic compound having a high glass transition temperature as a main chain, the thermal stability is excellent, and since the mobility of the main chain is relatively high as compared to that of an additional polymer, a photoreactive group can be freely moved in the main chain of the polymer. Accordingly, it is possible to overcome a slow photoreactive rate that is considered a disadvantage of a polymer material used to prepare an alignment film for known liquid crystal display devices.
    Type: Application
    Filed: March 21, 2008
    Publication date: April 15, 2010
    Inventors: Dai-Seung Choi, Hye-Young Jung, Sung-Ho Chun, Heon Kim, Sung-Don Hong, Dong-Woo Yoo