The Other Cyclo Of The Bicyclo Ring System Is Benzene (e.g., Phthalides, Etc.) Patents (Class 549/307)
  • Patent number: 9884835
    Abstract: A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: February 6, 2018
    Assignee: EVERFRONT BIOTECH INC.
    Inventor: Wen-Sen Li
  • Publication number: 20150045564
    Abstract: The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield.
    Type: Application
    Filed: January 3, 2013
    Publication date: February 12, 2015
    Inventors: Santhosh Rekula Reddy, Kishore Prasad Pragati, Kiran Naga, Arumugam Sudalai
  • Patent number: 8835639
    Abstract: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: September 16, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: John DeMattei, Adam R. Looker, Bobbianna J. Neubert-Langille, Martin Trudeau, Stefanie Roeper, Michael P. Ryan, Dahrika Milfred Yap Guerette, Brian R. Krueger, Peter Diederik Jan Grootenhuis, Fredrick F. Van Goor, Martyn Curtis Botfield, Gregor Zlokarnik
  • Patent number: 8653284
    Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: February 18, 2014
    Assignee: Milliken & Company
    Inventor: Jusong Xia
  • Patent number: 8604221
    Abstract: Disclosed is a method for producing a halogen-substituted phthalide, which includes a reaction step of reacting a halogen-substituted phthalic anhydride with sodium borohydride.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: December 10, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Hagiya, Yasutaka Aoyagi
  • Publication number: 20130245287
    Abstract: The present invention relates to a method comprising (A) reacting a ?-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an ?-methyl-?-keto acid; and (C) reducing the resulting ?-methyl-?-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 19, 2013
    Applicant: Takasago International Corporation
    Inventors: Kenji Yagi, Yasuhiro Komatsuki, Hideo Ujihara, Kenya Ishida
  • Patent number: 8518302
    Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation comprise as stabilizers at least one compound of the formula I wherein the general symbols are as defined in claim 1. The compounds of formula I are especially useful as stabilizers for protecting polymers and lubricants against oxidative, thermal or light-induced degradation and as scavengers for oxidized developer in color photographic material.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: August 27, 2013
    Assignee: BASF SE
    Inventors: Michèle Gerster, Peter Nesvadba
  • Publication number: 20130217898
    Abstract: The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ?-caprolactone was obtained at an isolated yield of 82%.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 22, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Kazuaki Ishihara, Muhammet Uyanik
  • Patent number: 8481759
    Abstract: The present invention relates to a method comprising (A) reacting a ?-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an ?-methyl-?-keto acid; and (C) reducing the resulting ?-methyl-?-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: July 9, 2013
    Assignee: Takasago International Corporation
    Inventors: Kenji Yagi, Yasuhiro Komatsuki, Hideo Ujihara, Kenya Ishida
  • Publication number: 20130072522
    Abstract: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
    Type: Application
    Filed: November 6, 2012
    Publication date: March 21, 2013
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventor: Vertex Pharmaceuticals Incorporated
  • Publication number: 20130059853
    Abstract: Novel biaryl compounds with phosphodiesterase inhibitory activity of the general formula (I), wherein R1, R2, R3, X, Y, Z1, Z2, Z3, and Z4 have the meanings defined herein, as well as their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
    Type: Application
    Filed: April 28, 2011
    Publication date: March 7, 2013
    Applicant: LEO PHARMA A/S
    Inventors: Simon Feldbaek Nielsen, Anne Marie Horneman, Jesper Lau, Jens Christian Hojland Larsen
  • Publication number: 20130030193
    Abstract: The present invention relates to a method comprising (A) reacting a ?-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an ?-methyl-?-keto acid; and (C) reducing the resulting ?-methyl-?-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof.
    Type: Application
    Filed: May 30, 2012
    Publication date: January 31, 2013
    Inventors: Kenji Yagi, Yasuhiro Komatsuki, Hideo Ujihara, Kenya Ishida
  • Publication number: 20120231141
    Abstract: [Object] To improve bitterness or astringency, for example, to reduce stimulative bitterness or astringency of bitter or astringent food and drink, without imparting unnecessary taste or aroma to the food and drink. [Solution] A bitterness- or astringency-improving agent for bitter or astringent food and drink includes phthalides as an active ingredient. Addition of a very small amount of phthalides that are not sensed as aroma to food and drink improves undesirable bitterness or astringency of various bitter or astringent food and drink products and enhances or provides pleasant bitterness or astringency.
    Type: Application
    Filed: November 12, 2010
    Publication date: September 13, 2012
    Inventors: Yoshiko Kurobayashi, Setsuko Nakai, Kikue Kubota
  • Publication number: 20120225180
    Abstract: [Object] To improve saltiness, for example, to reduce feeling of stimulation of saltiness of salty food and drink, without imparting unnecessary taste or aroma to the food and drink. [Solution] A saltiness-improving agent for salty food and drink includes phthalides as an active ingredient. Addition of a very small amount of phthalides that are not sensed as aroma to food and drink improves undesirable saltiness of various salty food and drink products and enhances or provides pleasant saltiness.
    Type: Application
    Filed: November 12, 2010
    Publication date: September 6, 2012
    Inventors: Yoshiko Kurobayashi, Setsuko Nakai, Kikue Kubota
  • Patent number: 8247416
    Abstract: 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: August 21, 2012
    Assignee: Kudos Pharmaceuticals Limited
    Inventors: Keith Allan Menear, Anthony Peter Ottridge, Derek John Londesbrough, Michael Raymond Hallett, Keith Raymond Mulholland, John David Pittam, David Dermot Patrick Laffan, Ian Woodward Ashworth, Martin Francis Jones, Janette Helen Cherryman
  • Publication number: 20120142946
    Abstract: Disclosed is a method for producing a halogen-substituted phthalide, which includes a reaction step of reacting a halogen-substituted phthalic anhydride with sodium borohydride.
    Type: Application
    Filed: May 19, 2010
    Publication date: June 7, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Koji Hagiya, Yasutaka Aoyagi
  • Patent number: 8105504
    Abstract: Organic materials which possess outstanding stability to oxidative, thermal or light-induced degradation comprise as stabilizers at least one compound of the formula (I) wherein the general symbols are as defined in claim 1. The compounds of formula I are especially useful as stabilizers for protecting polymers and lubricants against oxidative, thermal or light-induced degradation and as scavengers for oxidized developer in color photographic material.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: January 31, 2012
    Assignee: BASF SE
    Inventors: Michèle Gerster, Peter Nesvadba
  • Publication number: 20110130574
    Abstract: The present invention relates to an esterification catalyst composition that includes a zirconium compound and a method for producing an ester compound, which includes the steps of esterifying alcohol and carboxylic acid compounds by using the same, and it may be applied to a mass synthesis process.
    Type: Application
    Filed: January 28, 2011
    Publication date: June 2, 2011
    Inventors: Dai-Seung CHOI, Yu-Chan Kang, Sung-Ho Chun, Heon Kim, Dong-Woo Yoo
  • Publication number: 20110123464
    Abstract: Described is the use of specific lactone compounds for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding antioxidant properties.
    Type: Application
    Filed: June 19, 2009
    Publication date: May 26, 2011
    Applicant: BASF SE
    Inventors: Oliver Reich, Michael Schork
  • Publication number: 20100298427
    Abstract: The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R1 is butyl or butyryl if R2 is hydroxyl but is butyl if R2 is hydrogen; or R1 and R2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3-(?,?-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is X1, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation.
    Type: Application
    Filed: June 18, 2010
    Publication date: November 25, 2010
    Applicant: DSM IP ASSETS B.V.
    Inventors: Ann Fowler, Daniel Raederstorff, Goede Schuler, Joseph Schwager
  • Publication number: 20100184852
    Abstract: The present invention refers to compounds of the general formula (I) wherein R1 is hydrogen or hydroxy; R2 is butyl or butyryl if R1 is hydroxy, but R2 is butyl if R1 is hydrogen; or R3 and R2 taken together are 1-propylidene or 1-butylidene optionally substituted by hydroxy, methyl, or 3-(?, ?-dimethylacryloyloxy); the dotted line is an optional bond; X is an optionally substituted aliphatic C4-residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is X1, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 and R4 are, independently from each other, hydrogen or hydroxy; and R5 is hydroxy or butyryl, for use in the treatment of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions containing such compounds, and their uses.
    Type: Application
    Filed: August 10, 2007
    Publication date: July 22, 2010
    Inventors: Antoine De Saizieu, Regina Goralczyk, Goede Schueler
  • Publication number: 20100105739
    Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
    Type: Application
    Filed: January 7, 2010
    Publication date: April 29, 2010
    Inventors: Sara S. Hadida Ruah, Mark T. Miller, Brian Bear, Jason McCartney, Peter D.J. Grootenhuis
  • Patent number: 7692006
    Abstract: 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: April 6, 2010
    Assignee: Kudos Pharmaceuticals Limited
    Inventors: Keith Allan Menear, Anthony Peter Ottridge, Derek John Londesbrough, Michael Raymond Hallett, Keith Raymond Mulholland, John David Pittam, David Dermot Patrick Laffan, Ian Woodward Ashworth, Martin Francis Jones, Janette Helen Cherryman
  • Publication number: 20100010124
    Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.
    Type: Application
    Filed: September 18, 2009
    Publication date: January 14, 2010
    Inventor: Jusong Xia
  • Publication number: 20090306408
    Abstract: A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug antagonizes the action of group II metabotropic glutamate receptors and shows high activity in oral administration A 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative represented by formula [I] [wherein R1 and R2 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; X represents a hydrogen atom or a fluorine atom; Y represents —OCHR3R4 or the like (wherein R3 and R4 are identical or different, and each represents a hydrogen atom, a C1-10alkyl group or the like; and n represents integer 1 or 2)], a pharmaceutically acceptable salt thereof or a hydrate thereof.
    Type: Application
    Filed: July 29, 2009
    Publication date: December 10, 2009
    Applicant: TAISHO PHARMACEUTICAL CO., LTD.
    Inventors: Akito YASUHARA, Kazunari Sakagami, Hiroshi Ohta, Atsuro Nakazato
  • Patent number: 7601853
    Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: October 13, 2009
    Assignee: Milliken & Company
    Inventor: Jusong Xia
  • Patent number: 7569576
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: August 4, 2009
    Assignee: XenoPort, Inc.
    Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Publication number: 20090192218
    Abstract: The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
    Type: Application
    Filed: March 27, 2009
    Publication date: July 30, 2009
    Inventors: Daniel D'Orazio, Antoine De Saizieu, Goede Schueler, Daniel Raederstorff, Sandra Renata Teixeira, Ying Wang Schmidt, Peter Weber, Swen Wolfram
  • Patent number: 7528266
    Abstract: The present invention relates to a first compound having the formula wherein R is halogen, R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkyl, C1-C8haloalkyl, aryl-C1-C8-alkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R3 is C2-C5alkyl or C1-C5haloalkyl, or a salt thereof. The present invention is also directed to a second compound having the formula wherein R is fluorine, bromine, iodine, R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkyl, C1-C8- haloalkyl, aryl-C1-C8alkyl or aryl; n is 0, 1, 2 or 3; X is O or S; and R2 is hydrogen, C1-C4alkyl or C1-C4haloalkyl, with the proviso that R1 is different from C1-C8 alkyl or aryl if X is S, R is different from iodine if R2 is methyl, and R is different from fluorine, bromine or iodine if R2 is hydrogen.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: May 5, 2009
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Anita Schnyder, Marco Passafaro, Thomas Rapold
  • Publication number: 20080237544
    Abstract: Most carbon-centered free radical antioxidants are generated through hydrogen abstraction. Disclosed herein a new class of antioxidant precursor compounds of the formula A-B, wherein upon exposure of the compounds to an increase in temperature, the compounds undergo at least partial dissociation into free radicals Ao and Bo at least one of which may be functional as an antioxidant. Preferably, each of Ao and Bo is a carbon centered free radical.
    Type: Application
    Filed: January 21, 2005
    Publication date: October 2, 2008
    Inventor: Juan C. Scaiano
  • Publication number: 20080217585
    Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.
    Type: Application
    Filed: May 19, 2008
    Publication date: September 11, 2008
    Inventor: Jusong Xia
  • Patent number: 7411077
    Abstract: A process for the preparation of citalopram and the pharmaceutically acceptable salts therof is disclosed by reacting 5-cyanophthalide with a 4-fluorophenyl magnesium halide, reducing the 3-hydroxymethyl-4-(4-fluorobenzoyl)benzonitrile with an agent reducing ketones to alcohols, submitting the thus-obtained 3-hydroxymethyl-4-[(4-fluorophenyl)hydroxymethyl)benzonitrile to a cyclization reaction to give 1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile without 1,1-bis(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile and treating 1,1-bis(4 fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile with a 3-(dimetylamino)propyl halide in the presence of a base.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: August 12, 2008
    Assignee: Adorken Technology SpA
    Inventors: Giovanni Cotticelli, Leone Dall'Asta, Gianluca Di Lernia
  • Patent number: 7408060
    Abstract: This invention relates to nonsteroidal progesterone receptor modulators of general formula I, a process for their production, the use of progesterone receptor modulators for the production of pharmaceutical agents as well as pharmaceutical compositions that contain these compounds. The compounds according to the invention are suitable for therapy and prophylaxis of gynecological diseases, such as endometriosis, leiomyomas of the uterus, dysfunctional bleeding and dysmenorrhea, as well as for the therapy and prophylaxis of hormone-dependent tumors and for use for female birth control as well as for hormone replacement therapy.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: August 5, 2008
    Assignee: Schering AG
    Inventors: Norbert Schmees, Ulrich Bothe, Wolfgang Schwede, Carsten Moeller, Ulrike Fuhrmann, Anja Schmidt
  • Patent number: 7390912
    Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: June 24, 2008
    Assignee: Milliken & Company
    Inventor: Jusong Xia
  • Patent number: 7271273
    Abstract: The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: September 18, 2007
    Assignee: H. Lundbeck A/S
    Inventors: Hans Petersen, Michael Harold Rock
  • Patent number: 7192939
    Abstract: The present invention relates to the novel isolated 12–30 strain of Pestalotiopsis microspora capable of producing novel antioxidant and antimycotic agents. The present invention also relates to the novel isolated 3,5,7 trisubstituted isobenzofuranone and derivatives thereof, methods of isolating the novel isobenzofuranone from cultures P. microspora 12–30, and to novel uses of the compound as an antioxidant and antimycotic agent. The present invention further relates to a novel 1,5,7 trisubstituted 1,3-dihydroisobenzofuran and derivatives thereof, methods of isolating this novel compound from cultures of Pestalotiopsis microspora 12–30, and to uses thereof.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: March 20, 2007
    Assignee: Montana State University
    Inventors: Gary Strobel, Eugene Ford, James K. Harper
  • Patent number: 7183421
    Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 27, 2007
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Hideo Tanaka, Yutaka Kameyama
  • Patent number: 7122687
    Abstract: In one aspect, the present invention provides a process for producing a sodium salt of an immunosupressant of Formula I
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: October 17, 2006
    Assignee: Sunesis Pharmaceuticals, Inc.
    Inventors: Acharya Poornaprajna, Gopeekrishnan Sreenilayam, Sambasivam Ganesh
  • Patent number: 7038065
    Abstract: A process for catalytically generating organic substances by partial oxidation of an organic feedstock in the presence of molecular oxygen at temperatures in the range from 200 to 500° C. in at least one cooling-tube reactor, wherein 40 to 100 wt-% of the total amount of catalyst is disposed as a coating on the outside of the cooling tubes.
    Type: Grant
    Filed: July 11, 2001
    Date of Patent: May 2, 2006
    Assignee: MG Technologies AG
    Inventors: Volker Franz, Helmuth Domes
  • Patent number: 7026351
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: April 11, 2006
    Assignee: Xenoport, Inc.
    Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Patent number: 6911548
    Abstract: A method for the preparation of 5-cyanophthalide comprising treatment of a compound of formula IV wherein X is O or S; R1-R2 are each independently selected from hydrogen and C1-6 alkyl, or R1 and R2 together form a C2-5 alkylene chain thereby forming a spiro-ring; R3 is selected from hydrogen and C1-6 alkyl, R4 is selected from hydrogen, C1-6 alkyl, a carboxy group or a precursor group therefore, or R3 and R4 together form a C2-5 alkylene chain thereby forming a spiro-ring; with a dehydration agent or alternatively where X is S, thermally cleavage of the thiazoline ring or treatment with a radical initiator, such as peroxide or with light, to form 5-cyanophthalide, which is an important intermediate used in the preparation of the antidepressant drug citalopram.
    Type: Grant
    Filed: July 8, 2002
    Date of Patent: June 28, 2005
    Assignee: H. Lundbeck A/S
    Inventor: Hans Petersen
  • Patent number: 6888010
    Abstract: There is described a process for the preparation of 5-formylphthalide by hydrogenation of a halide of 5-carboxyphthalide, dissolved in a dipolar aprotic solvent, in the presence of a catalyst. Furthermore, the use of 5-formylphthalide in the preparation of citalopram is described.
    Type: Grant
    Filed: January 31, 2004
    Date of Patent: May 3, 2005
    Assignee: Infosint SA
    Inventors: Leone Dall'Asta, Giovanni Cotticelli
  • Patent number: 6872839
    Abstract: Benzofuran-2-ones, compositions comprising benzofuranones, processes for preparing them, and their use as colorants for high or low molecular mass organic material.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: March 29, 2005
    Assignee: Cibaspecialty Chemicals Corp.
    Inventors: Leonhard Feiler, Thomas Ruch, Olof Wallquist, Peter Nesvadba
  • Patent number: 6868215
    Abstract: A dye thin film containing a dye compound represented by the general formula (I), an optical switch, an optical distributor, an optical modulator and an optical switch array having the dye thin film, as well as a method for producing a dye thin film are provided. The method includes the step of coating the solution of the dye compound on a substrate: where R1 and R2 may be identical or different from each other and each represents, respectively, a linear alkyl group or a branched alkyl group, the dye thin film having high thermal stability, having intense absorption at approximately 1.3 ?m and having ultrafast response characteristic.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: March 15, 2005
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Minquan Tian, Makoto Furuki, Satoshi Tatsuura, Yasuhiro Sato, Izumi Iwasa, Lyong Sun Pu
  • Patent number: 6864254
    Abstract: An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is useful especially as a remedy for kidney diseases, cerebrovascular diseases, or circulatory diseases. The novel hydroxyformamidine derivative or pharmacologically acceptable salt thereof is also provided.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: March 8, 2005
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Masakazu Sato, Noriyuki Miyata, Takaaki Ishii, Yuko Kobayashi, Hideaki Amada
  • Patent number: 6858743
    Abstract: The invention relates to a method for the production of 2-coumarone or substituted 2-coumarones, whereby cyclohexanone or substituted cyclohexanone is reacted with a carboxyl-containing acylating agent a) to give methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetate or substituted methyl 2-(2-oxo-cyclohexyl)-2-hydroxyacetates, which are either a1) directly converted to 2-coumarone or substituted 2-coumarones by means of catalytic gas-phase dehydrogenation, or a2) dehydrated by means of azeotropic distillation under basic conditions, or by use of a strong acid, or a strongly acidic ion exchanger to a mixture of methyl 2-oxocyclohexylidenacetate and the enol-lactone of the 2-oxocyclohexylidenacetic acid, or a mixture of substituted methyl 2-oxocyclohexylidenacetate and the enol-lactone of the substituted 2-oxocyclohexylidenacetic acid, which is finally converted in turn by catalytic gas-phase dehydrogenation to 2-coumarone, or substituted 2-coumarones, or b) are directly converted under acidic or basic conditions into a
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: February 22, 2005
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co, KG
    Inventors: Michael Stanek, Peter Hildebrand, Curt Zimmermann, Marianne Castelijns
  • Patent number: 6825363
    Abstract: A dibenzofuranonylium methylate compound represented by the following formula (I), having maximum absorption wavelength of over 1 &mgr;m, high thermal stability and good solubility in organic solvents, and a production method thereof are provided: where R1 and R2 may be identical or different from each other and each represents a linear alkyl group or a branched alkyl group, respectively.
    Type: Grant
    Filed: April 2, 2003
    Date of Patent: November 30, 2004
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Minquan Tian, Makoto Furuki, Lyong Sun Pu, Yasuhiro Sato, Izumi Iwasa, Satoshi Tatsuura
  • Publication number: 20040225136
    Abstract: There is described a process for the preparation of 5-formylphthalide by hydrogenation of a halide of 5-carboxyphthalide, dissolved in a dipolar aprotic solvent, in the presence of a catalyst. Furthermore, the use of 5-formylphthalide in the preparation of citalopram is described.
    Type: Application
    Filed: January 31, 2004
    Publication date: November 11, 2004
    Inventors: Leone Dall'Asta, Giovanni Cotticelli
  • Patent number: 6809208
    Abstract: The invention describes novel compounds of the formula (I) wherein the general symbols are as defined in claim (1) and R1 is an aromatic radical with electron withdrawing substituents, as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation and as scavengers for oxidized developer in color photographic material.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: October 26, 2004
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Michael Tinkl, Oliver Dosenbach, Peter Nesvadba, Martin Wolff, Bruno Rotzinger, Dietmar Mäder
  • Patent number: 6797830
    Abstract: The present invention provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound thereon and an oxidative catalyst thereon, and oxidizing the alcohol compound in the presence of an oxidizing agent, giving an oxide higher in oxidizing degree than the alcohol compound, and also provides a process for producing an oxide from an alcohol compound, the process comprising the steps of causing silica gel to carry the alcohol compound, and subjecting the alcohol compound to an electrolytic oxidation, giving an oxide higher in oxidizing degree than the alcohol compound.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: September 28, 2004
    Assignee: Otsuka Kagaku Kabushiki Kaisha
    Inventors: Hideo Tanaka, Yutaka Kameyama