Acyclic -c(=x)-, Wherein X Is Chalcogen, Attached Directly Or Indirectly To The Lactone Ring By Nonionic Bonding Patents (Class 549/318)
  • Patent number: 10968397
    Abstract: A method for conversion of levulinic acid and to a hydrocarbon composition obtainable by the method. The method includes a step of providing a feedstock, a conversion step of subjecting the feedstock to a C—C coupling reaction and a hydrotreatment, and a hydrodeoxygenation step. The content of levulinic acid dimer derivatives having 4 oxygen atoms subjected to the hydrodeoxygenation step is 20 wt.-% or more.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: April 6, 2021
    Assignee: NESTE OYJ
    Inventors: Jukka Myllyoja, Marina Lindblad, Mats Käldström, Rami Piilola, Elias Ikonen
  • Patent number: 9139547
    Abstract: The present invention relates to a multi-stage method for preparing alkali metal salts of specific 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters of the formula (I), in which M and R1 are as defined in the description, which proceeds from malonic ester and does not require isolation of intermediates.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: September 22, 2015
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Wahed Ahmed Moradi, Christian Funke, Taraneh Farida, Albert Schnatterer, Reiner Rosellen, Volker Brehme, Stefanie Rinker
  • Publication number: 20150126753
    Abstract: The art relates to provision of a method for manufacturing an (meth)acrylic polymerizable monomer that can be used in various applications, such as an optical material, a resist material, a coating material and a laminate material, and provision of a new ?-(meth)acryloyloxy-?-butyrolactone compound by applying the manufacturing method. The method for manufacturing the ?-(meth)acryloyloxy-?-butyrolactone compound is described, in which a (meth)acrylate compound having a carbonyl group and a ketene compound are condensed and isomerized. Further, the manufacturing method is applied to the new ?-(meth)acryloyloxy-?-butyrolactone compound.
    Type: Application
    Filed: April 23, 2013
    Publication date: May 7, 2015
    Applicant: JNC CORPORATION
    Inventors: Akihiro Ezoe, Hideki Hayashi, Shunji Oshima
  • Publication number: 20150105460
    Abstract: Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases.
    Type: Application
    Filed: June 4, 2012
    Publication date: April 16, 2015
    Inventors: Weiwei Su, Yonggang Wang, Fengyin Liang, Ning Wang, Zhong Pei, Haibin Liu
  • Patent number: 9005874
    Abstract: There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern the compound represented by general formula (1-1): wherein each of R1 and R3 independently represents a single bond or a divalent linking group; A represents a divalent linking group; each of R2 and R4 independently represents a hydroxyl group, a hydrocarbon group which may have a substituent, or a group represented by general formula (1-an1), (1-an2) or (1-an3), provided that at least one of R2 and R4 represents a group represented by general formula (1-an1), (1-an2) or (1-an3); and n0 is preferably 0 or 1, and wherein Y1 represents a single bond or —SO2—; R5 represents a linear or branched monovalent hydrocarbon group of 1 to 10 carbon atoms, cyclic monovalent hydrocarbon group of 3 to 20 carbon atoms or monovalent hydrocarbon group of 3 to 20 carbon atoms having a cyclic partial structure which may be substituted with a fluorine atom; and M+ represents an organic ca
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: April 14, 2015
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Yoshitaka Komuro, Yoshiyuki Utsumi, Akiya Kawaue, Masatoshi Arai
  • Patent number: 8980795
    Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: March 17, 2015
    Assignee: King Abdullah University of Science and Technology
    Inventors: Salim Al-Babili, Adrian Alder
  • Publication number: 20140287924
    Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.
    Type: Application
    Filed: April 25, 2012
    Publication date: September 25, 2014
    Inventors: Salim Al-Babili, Adrian Alder
  • Patent number: 8822383
    Abstract: Provided is a novel compound which can germinate seeds of root parasitic plants, more specifically, a compound represented by the formula: wherein R1, R2, R3, R4, and R5 are the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group, or R1 and R2 are linked together to form a lower alkylenedioxy group, or R1 and R2 together with the adjacent carbon atoms form a benzene ring, or R2 and R3 are linked together to form a lower alkylenedioxy group, or R2 and R3 together with the adjacent carbon atoms form a benzene ring, R6 represents a hydrogen atom or a lower alkyl group, X and Y are the same or different and each represents an oxygen atom and a sulfur atom, and n represents an integer of 0, 1 or 2, and a method for controlling root parasitic plants.
    Type: Grant
    Filed: March 30, 2011
    Date of Patent: September 2, 2014
    Assignees: National University Corporation KOBE UNIVERSITY, Sumitomo Chemical Company, Limited
    Inventors: Mitsuru Sasaki, Yukihiro Sugimoto, Hirosato Takikawa, Hideyoshi Miyake, Noritada Matsuo
  • Publication number: 20140220492
    Abstract: A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, including a base component containing a polymeric compound having a structural unit derived from a compound represented by general formula (a0-1). R1 and R2 each independently represents a group represented by general formula (a0-2) or a functional group; V1 and V2 each represents a single bond or an alkylene group of C1 to C10 which may have a substituent; Y1 represents a single bond or a divalent linking group; Y2 represents a fluorinated alkylene group of C1 to C4 which may have a substituent; L1 represents O or a group represented by —NR?1—(R?1 represents H or an alkyl group of C1 to C5); Mm+ represents an organic cation having a valency of m; and m represents an integer of 1 or more.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Takaaki Kaiho, Yoshitaka Komuro
  • Publication number: 20140147481
    Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 29, 2014
    Applicants: UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Lena Gerwick, Huykjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
  • Publication number: 20140148604
    Abstract: Process for preparing sodium or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters, comprising the reaction of a malonic ester with potassium hydroxide to give the corresponding malonic ester potassium salt of the formula (III) which is then reacted further with a chloroacetic ester to give a compound of the formula (V) followed by a ring closure reaction in which the compound of the formula (V) is reacted with a sodium or potassium alkoxide of the formula ZOR1 where R1, R2, R3 and K are each as defined in the description.
    Type: Application
    Filed: February 29, 2012
    Publication date: May 29, 2014
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Christian Funke, Taraneh Farida, Stefan Beeck, Norbert Lui, Berndt Maiwald
  • Publication number: 20140011845
    Abstract: Disclosed are cyclic dione derivatives represented by formula (I), wherein the substituents are as defined in the description. The preparation method, intermediate and use thereof are also provided.
    Type: Application
    Filed: December 30, 2011
    Publication date: January 9, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Stephane Andre Marie Jeanmart, Long Lu, Yaming Wu, Lisheng Mao, Michel Muehlbeach
  • Publication number: 20130085068
    Abstract: Provided is a novel compound which can germinate seeds of root parasitic plants, more specifically, a compound represented by the formula: wherein R1, R2, R3, R4, and R5 are the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group, or R1 and R2 are linked together to form a lower alkylenedioxy group, or R1 and R2 together with the adjacent carbon atoms form a benzene ring, or R2 and R3 are linked together to form a lower alkylenedioxy group, or R2 and R3 together with the adjacent carbon atoms form a benzene ring, R6 represents a hydrogen atom or a lower alkyl group, X and Y are the same or different and each represents an oxygen atom and a sulfur atom, and n represents an integer of 0, 1 or 2, and a method for controlling root parasitic plants.
    Type: Application
    Filed: March 30, 2011
    Publication date: April 4, 2013
    Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, National University Corporation KOBE UNIVERSITY
    Inventors: Mitsuru Sasaki, Yukihiro Sugimoto, Hirosato Takikawa, Hideyoshi Miyake, Noritada Matsuo
  • Patent number: 8318955
    Abstract: Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates of the formula (I) and/or (I?) comprising the reaction of a haloacetyl chloride compound of the formula (II) with a malonic ester of the formula (III) in which Hal, R1 and R2 have the definitions stated in the application, in the presence of a suitable base and optionally in the presence of a solvent; the addition of a sufficient amount of water to the reaction mixture; and the isolation of the desired 2,4-dioxotetrahydrofuran-3-carboxylate.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: November 27, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich, Christian Funke
  • Publication number: 20120276546
    Abstract: A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 1, 2012
    Applicant: Kao Corportation
    Inventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
  • Patent number: 7927780
    Abstract: A compound represented by formula (I); and a compound represented by formula (b1-1): wherein X represents —O—, —S—, —O—R3— or —S—R4—, wherein each of R3 and R4 independently represents an alkylene group of 1 to 5 carbon atoms; R2 represents an alkyl group of 1 to 6 carbon atoms, an alkoxy group of 1 to 6 carbon atoms, a halogenated alkyl group of 1 to 6 carbon atoms, a halogen atom, a hydroxyalkyl group of 1 to 6 carbon atoms, a hydroxyl group or a cyano group; a represents an integer of 0 to 2; Q1 represents an alkylene group of 1 to 12 carbon atoms or a single bond; Y1 represents an alkylene group of 1 to 4 carbon atoms or a fluorinated alkylene group; M+ represents an alkali metal ion; and A+ represents an organic cation.
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: April 19, 2011
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Akiya Kawaue, Takeshi Iwai, Hideo Hada, Shinichi Hidesaka, Tsuyoshi Kurosawa, Natsuko Maruyama, Kensuke Matsuzawa, Takehiro Seshimo, Hiroaki Shimizu, Tsuyoshi Nakamura
  • Publication number: 20110060147
    Abstract: Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates of the formula (I) and/or (I?) comprising the reaction of a haloacetyl chloride compound of the formula (II) with a malonic ester of the formula (III) in which Hal, R1 and R2 have the definitions stated in the application, in the presence of a suitable base and optionally in the presence of a solvent; the addition of a sufficient amount of water to the reaction mixture; and the isolation of the desired 2,4-dioxotetrahydrofuran-3-carboxylate.
    Type: Application
    Filed: August 11, 2010
    Publication date: March 10, 2011
    Applicant: Bayer CropScience AG
    Inventors: Norbert Lui, Jens-Dietmar Heinrich, Christian Funke
  • Publication number: 20100316954
    Abstract: Disclosed is a novel monomer having a lactone skeleton, which is useful typically as a monomer component typically for a highly functional polymer, because, when the monomer is applied typically to a resist resin, the resin is satisfactory stable and resistant typically to chemicals, is highly soluble in organic solvents, and has improved hydrolyzability and/or water solubility after hydrolysis. The monomer having a lactone skeleton is represented by following Formula (1), wherein Ra represents a hydrogen atom, halogen atom, or substituted or unsubstituted alkyl group having 1 to 6 carbon atoms; R1 represents a group having a lactone skeleton; and Y represents a bivalent organic group having 1 to 6 carbon atoms.
    Type: Application
    Filed: January 21, 2009
    Publication date: December 16, 2010
    Inventors: Hiroshi Koyama, Mari Sumida, Hiroki Tanaka
  • Patent number: 7838693
    Abstract: The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-?-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: November 23, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Miall Cedilote, Thomas Cleary, Hans Iding, Pingsheng Zhang
  • Patent number: 7759044
    Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
  • Publication number: 20100050719
    Abstract: The present invention concerns the field of bacterial biocontrol. More precisely, the invention relates to the identification of chemicals which promote the growth of bacteria inactivating NAHL, such as gamma-caprolactone (GCL) and 4-heptanolide (HTN) and their use in soil additives.
    Type: Application
    Filed: January 18, 2008
    Publication date: March 4, 2010
    Inventors: Denis Faure, Amélie Cirou, Yves Dessaux
  • Publication number: 20080103191
    Abstract: Pharmaceutical composition comprising one or more entacapone derivatives and one or more pharmaceutically acceptable carriers, a process for producing the pharmaceutical composition, specific entacapone derivatives, a process for the preparation of entacapone derivatives, and the use of the entacapone derivatives for the preparation of a medicament.
    Type: Application
    Filed: June 14, 2007
    Publication date: May 1, 2008
    Inventors: Klaus Hansen, Robert Kraemer, Thomas Lauterbach, Dirk Schmidt, Fritz Paar, Petra Pfeiffer, Detlef Geffken, Wolfgang Thimann, Katharina Wehner
  • Patent number: 7026351
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: April 11, 2006
    Assignee: Xenoport, Inc.
    Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Patent number: 6838128
    Abstract: The invention relates to chiral nonracemic liquid crystal compounds which are useful as components in liquid crystal compositions to impart high polarization to the mixture. The materials of this invention can be combined with liquid crystal host materials to impart improved properties to mixtures. Chiral nonracemic compounds of this invention can function as additives or dopants in host materials to impart chirality into an LC material.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: January 4, 2005
    Assignee: Displaytech, Inc.
    Inventors: Michael Wand, Xin Hua Chen
  • Patent number: 6828276
    Abstract: There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radicals, X1 is a hetero atom, X2 is a chain of carbon atoms, L is a chain-like element, R1, R2, R3, R4, R5 are various radicals, and Y and Z are monoatomic bridge elements.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: December 7, 2004
    Assignee: Aventis CropScience GmbH
    Inventors: Thomas Seitz, Andreas van Almsick, Lothar Willms, Hermann Bieringer, Thomas Auler, Hubert Menne
  • Patent number: 6489492
    Abstract: The present invention relates to a novel chiral derivative of Garcinia acid bearing lactone ring moiety of formula I, wherein: R1=R3=alkali salt of carboxyl acid, or acid chloride or lower esters or part of N-substituted cyclic imides. R2=hydroxyl or protected hydroxyl group and a process for preparing the same.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: December 3, 2002
    Assignee: Department of Science and Technology
    Inventors: Ibrahim Ibnu Saud, Grace Thomas, Paleappadam Vavan Sasi
  • Patent number: 6486196
    Abstract: The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I).
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: November 26, 2002
    Assignee: Dr. Reddy's Research Foundation
    Inventors: Srinivas Nanduri, Sairam Pothukuchi, Sriram Rajagopal, Venkateswarlu Akella, Sunilkumar Bhadramma Kochunarayana Pillai, Ranjan Chakrabarti
  • Publication number: 20020133028
    Abstract: In industrial production of &ohgr;-hydroxyaliphatic acid being an important intermediate for large cyclic lactone-based perfumes, using dicarboxylate ester which is inexpensive and readily obtainable, a method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided.
    Type: Application
    Filed: January 14, 2002
    Publication date: September 19, 2002
    Applicant: Soda Aromatic Co., Ltd.
    Inventors: Hideaki Takaoka, Sigeru Wada, Nobuhiko Ito, Akio Hasebe, Shinzo Imamura, Hideo Muraoka
  • Patent number: 6395724
    Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: May 28, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin
  • Patent number: 6388101
    Abstract: Proposed is a chemical-sensitization positive-working photoresist composition for photolithographic patterning in the manufacture of semiconductor devices having high transparency even to ultraviolet light of very short wavelength such as ArF excimer laser beams of 193 nm wavelength to exhibit high photosensitivity and capable of giving a patterned resist layer with high pattern resolution. The composition comprises (A) a resinous ingredient which is subject to an increase of the solubility in an aqueous alkaline developer solution in the presence of an acid and (B) a radiation-sensitive acid-generating compound. Characteristically, the resinous ingredient as the component (A) is a (meth)acrylic copolymer of which from 20% to 80% by moles of the monomeric units are derived from a (meth)acrylic acid ester of which the ester-forming group has a specific oxygen-containing heterocyclic ring structure.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: May 14, 2002
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Hideo Hada, Kazufumi Sato, Hiroshi Komano
  • Publication number: 20020010341
    Abstract: The use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis is provided.
    Type: Application
    Filed: April 17, 2001
    Publication date: January 24, 2002
    Inventors: Gebre-mariam Mesfin, Richard K. Jensen
  • Publication number: 20010051734
    Abstract: In industrial production of &ohgr;-hydroxyaliphatic acid being an important intermediate for large cyclic lactone-based perfumes, using dicarboxylate ester which is inexpensive and readily obtainable, a method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided.
    Type: Application
    Filed: June 28, 2001
    Publication date: December 13, 2001
    Applicant: Soda Aromatic Co., Ltd.
    Inventors: Hideaki Takaoka, Sigeru Wada, Nobuhiko Ito, Akio Hasebe, Shinzo Imamura, Hideo Muraoka
  • Patent number: 6313321
    Abstract: The present invention provides a process for preparing &bgr;-hydroxy-&ggr;-butyrolactone or &bgr;-methyl-&bgr;-hydroxy-&ggr;-butyrolactone represented by the formula (1): wherein R1 is hydrogen or methyl, which entails a) cyanating glycidol or 2-methyl-2,3-epoxypropanol, b) hydrolyzing the product of step a), and c) lactonizing the product of step b).
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: November 6, 2001
    Assignee: Mitsubishi Rayon Co., Ltd.
    Inventors: Naoshi Murata, Kunihiko Sakano, Tetsuya Ikemoto
  • Patent number: 6271180
    Abstract: The present invention relates to novel compounds of the formula (I) in which Het represents one of the groups in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and to their use as pesticides and herbicides.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: August 7, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
  • Patent number: 6225288
    Abstract: Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: May 1, 2001
    Assignee: Merk Frosst Canada & Co.
    Inventors: Yongxin Han, Andre Giroux, Erich Grimm, Renee Aspiotis, Sebastien Francoeur, Robert Zamboni, Petpiboon Prasit, Christopher Bayly, Dan McKay, Cameron Black
  • Patent number: 6166070
    Abstract: Kodaistatins A and B, compounds of the molecular formula C.sub.35 H.sub.34 O.sub.11, and Kodaistatins C and D, compounds of the molecular formula C.sub.35 H.sub.34 O.sub.12, have antidiabetic activity.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: December 26, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Nirogi Venkata Satya Ramakrishna, Keshavapura Hosamane Sreedhara Swamy, Erra Koreswara Satya Vijayakumar, Suresh Rudra Nadkarni, Kenia Jayvanti, Andreas Herling, Herbert Kogler, Laszlo Vertesy, Rajan Mukund Panshikar, Kota Sridevi, Mythili Raman, Roda Maneck Dalal
  • Patent number: 6147228
    Abstract: A process for the isolation of Garcinia acid from the fresh or dried rinds of the fruits of Garcinia indica, Garcinia cambogia and/or Garcinia atroviridis.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: November 14, 2000
    Assignee: Department of Science and Technology Government of India
    Inventors: Ibrahim Ibnusaud, Tom Thomas Puthiaparampil, Beena Thomas
  • Patent number: 6100292
    Abstract: This invention relates to ketones represented by the following formula ##STR1## and to drugs in which such a ketone or pharmacologically acceptable salt thereof is an effective component.The ketones of the present invention encourage the production of platelets, red blood cells, white blood cells and the like, and can be used to prevent or treat cytopaenia brought about by cancer chemotherapy, radiotherapy, bone marrow transplantation and drug therapy, or by immunological abnormality or anaemia, and the like.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: August 8, 2000
    Assignee: Toray Industries, Inc.
    Inventors: Tsuyoshi Matsumoto, Hideki Kawai, Kiyoshi Okano, Katsuyuki Mori, Yasumoto Adachi
  • Patent number: 6060046
    Abstract: An antifouling composition that comprises an effective amount of a furanone of the structure shown and a suitable carrier therefor. In the figure, substituents R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom, a hydroxyl group, an alkyl group containing from 1 to 10 carbon atoms, an ether group containing from 1 to 10 carbon atoms, an ester group containing from 1 to 10 carbon atoms or a halogenated alkene containing from 1 to 10 carbon atoms or R.sub.2 and R.sub.3 together may comprise an unsubstituted or a halogenated alkene containing from 1 to 10 carbon atoms and R.sub.4 is a hydrogen or halogen atom, and a suitable carrier therefor.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: May 9, 2000
    Assignee: Unisearch Limited
    Inventors: Peter D. Steinberg, Peter C. De Nys
  • Patent number: 6017951
    Abstract: Novel nonpeptides characterized as having a carbamic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds are useful in treating elevated levels of endothelin and are therefore useful in the treatment of hypertension, myocardial infarction, diabetes, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythminas, asthma, chronic and acute renal failure, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, stroke, head injury, and ischemic bowel syndrome.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: January 25, 2000
    Assignee: Warner-Lambert Company
    Inventors: William C. Patt, Bill R. Reisdorph, Joseph T. Repine
  • Patent number: 5998408
    Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: December 7, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, Andrew Kotliar, William H. Parsons, Kathleen M. Rupprecht
  • Patent number: 5922759
    Abstract: Novel nonpeptides characterized as having a carbarimic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds as useful in treating elevated levels of endothelin and are therefore used in the treatment of hypertension, myocardial infarction, diabetes, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, chronic and acute renal failure, preeclamnpsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, stroke, head injury, and ischemic bowel syndrome.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: July 13, 1999
    Assignee: Warner-Lambert Company
    Inventors: William C. Patt, Bill R. Reisdorph, Joseph T. Repine
  • Patent number: 5905090
    Abstract: Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.
    Type: Grant
    Filed: April 29, 1998
    Date of Patent: May 18, 1999
    Assignee: Italfarmaco S.p.A.
    Inventors: Giorgio Bertolini, Mauro Biffi, Flavio Leoni, Maria Letizia Marchetti, Jacques Mizrahi, Flavio Somenzi, Paolo Mascagni
  • Patent number: 5869524
    Abstract: This invention provides compounds of formula 1 having the structure ##STR1## wherein: R.sup.1 is hydrogen, halogen, alkyl, alkoxy, fluoroalkoxy, trifluoromethyl, alkylthio, or SCF.sub.3R.sup.2 and R.sup.3 are each independently, hydrogen or alkyl, or R.sup.2 and R.sup.3 may be taken together to form a saturated cycloalkyl ring; andR.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each independently, hydrogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogen, fluoroalkoxy, CF.sub.3, or SCF.sub.3 which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: February 9, 1999
    Assignee: American Home Products Corporation
    Inventor: Amedeo A. Failli
  • Patent number: 5849217
    Abstract: An optically active compound represented by the formula R.sub.1 --A.sub.1 --A.sub.2 --X.sub.1 --A.sub.3 --(CH.sub.2).sub.p --L--A.sub.4 --R.sub.2, in which R.sub.1 is F, CN or straight chain, branched or cyclic alkyl and R.sub.2 is H, F, CH or straight chain or branched alkyl; A.sub.3 is 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl, pyrazine-2,5-diyl, pyridazine-3,6-diyl, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3-ditiane-2,5-diyl, thiophene-2,5-diyl, thiazole-2,5-diyl, thiaziazole-2,5-diyl, benzoxazole-2,5-diyl, benzoxazole-2,6-diyl, benzothiazole-2,5-diyl, benzothiazole-2,6-diyl, benzofuran-2,5-diyl, benzofuran-2,6-diyl, quinoxaline-2,6-diyl, quinoline-2,6-diyl, 2,6-naphthylene, indane-2,5-diyl, 2-alkylindane-2,5-diyl, indanone-2,6-diyl, 2-alkylindane-2,6-diyl, coumarane-2,5-diyl and 2-alkylcoumarane-2,5-diyl; A.sub.1, A.sub.2 and A.sub.4 are single bond or A.sub.3 ; X.sub.1 ' is a single bond, --COO--, --OCO--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: December 15, 1998
    Assignee: Canon Kabushiki Kaisha
    Inventors: Shinichi Nakamura, Takao Takiguchi, Takashi Iwaki, Takeshi Togano, Yoko Kosaka
  • Patent number: 5714484
    Abstract: Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a first portion which targets a desired cysteine protease and positions the inhibitor near the thiolate anion portion of the active site of the protease, and a second portion which covalently bonds to the cysteine protease and irreversibly deactivates that protease by providing a carbonyl or carbonyl-equivalent which is attacked by the thiolate anion of the active site of the cysteine protease to sequentially cleave a .beta.-dicarbonyl enol ether leaving group.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 3, 1998
    Assignee: Prototek, Inc.
    Inventors: Mary P. Zimmerman, Robert E. Smith, Mark Becker
  • Patent number: 5691373
    Abstract: Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: November 25, 1997
    Assignee: Warner-Lambert Company
    Inventors: Kent Alan Berryman, Annette Marian Doherty, Jeremy John Edmunds, William Chester Patt, Mark Stephen Plummer, Joseph Thomas Repine
  • Patent number: 5691374
    Abstract: The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 25, 1997
    Assignee: Merck Frosst Canada Inc.
    Inventors: Cameron Black, Erich Grimm, Zhaoyin Wang, Serge Leger
  • Patent number: 5610122
    Abstract: The present invention relates to a new 3-aryl-4-hydroxy-.DELTA..sup.3 -dihydrofuranone derivatives of the general formula (I) ##STR1## in which the radicals A, B, G, X, Y, Z and n have the meaning given in the description, to a plurality of processes for their preparation, and to their use as pesticides.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: March 11, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Thomas Bretschneider, Bernd-Wieland Kr uger, Hans-Joachim Santel, Markus Dollinger, Ulrike Wachendorff-Neumann, Christoph Erdelen
  • Patent number: 5596124
    Abstract: There is provided a method for safening herbicides in cereal crop plants by using 5-aryloxy-1,2 -(disubstituted)benzene compounds of formula I ##STR1## Further provided are compositions comprising a 5-aryloxy-1,2-(disubstituted)benzene compound of formula I.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: January 21, 1997
    Assignee: American Cyanamid Company
    Inventors: Gail E. Cary, Peter J. Wepplo, Barbara A. Bench