Acyclic -c(=x)-, Wherein X Is Chalcogen, Attached Directly Or Indirectly To The Lactone Ring By Nonionic Bonding Patents (Class 549/318)
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Patent number: 10968397Abstract: A method for conversion of levulinic acid and to a hydrocarbon composition obtainable by the method. The method includes a step of providing a feedstock, a conversion step of subjecting the feedstock to a C—C coupling reaction and a hydrotreatment, and a hydrodeoxygenation step. The content of levulinic acid dimer derivatives having 4 oxygen atoms subjected to the hydrodeoxygenation step is 20 wt.-% or more.Type: GrantFiled: December 28, 2016Date of Patent: April 6, 2021Assignee: NESTE OYJInventors: Jukka Myllyoja, Marina Lindblad, Mats Käldström, Rami Piilola, Elias Ikonen
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Patent number: 9139547Abstract: The present invention relates to a multi-stage method for preparing alkali metal salts of specific 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters of the formula (I), in which M and R1 are as defined in the description, which proceeds from malonic ester and does not require isolation of intermediates.Type: GrantFiled: July 29, 2013Date of Patent: September 22, 2015Assignee: BAYER CROPSCIENCE AGInventors: Wahed Ahmed Moradi, Christian Funke, Taraneh Farida, Albert Schnatterer, Reiner Rosellen, Volker Brehme, Stefanie Rinker
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Publication number: 20150126753Abstract: The art relates to provision of a method for manufacturing an (meth)acrylic polymerizable monomer that can be used in various applications, such as an optical material, a resist material, a coating material and a laminate material, and provision of a new ?-(meth)acryloyloxy-?-butyrolactone compound by applying the manufacturing method. The method for manufacturing the ?-(meth)acryloyloxy-?-butyrolactone compound is described, in which a (meth)acrylate compound having a carbonyl group and a ketene compound are condensed and isomerized. Further, the manufacturing method is applied to the new ?-(meth)acryloyloxy-?-butyrolactone compound.Type: ApplicationFiled: April 23, 2013Publication date: May 7, 2015Applicant: JNC CORPORATIONInventors: Akihiro Ezoe, Hideki Hayashi, Shunji Oshima
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Publication number: 20150105460Abstract: Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases.Type: ApplicationFiled: June 4, 2012Publication date: April 16, 2015Inventors: Weiwei Su, Yonggang Wang, Fengyin Liang, Ning Wang, Zhong Pei, Haibin Liu
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Patent number: 9005874Abstract: There are provided a novel compound, a polymeric compound, a resist composition, an acid generator and a method of forming a resist pattern the compound represented by general formula (1-1): wherein each of R1 and R3 independently represents a single bond or a divalent linking group; A represents a divalent linking group; each of R2 and R4 independently represents a hydroxyl group, a hydrocarbon group which may have a substituent, or a group represented by general formula (1-an1), (1-an2) or (1-an3), provided that at least one of R2 and R4 represents a group represented by general formula (1-an1), (1-an2) or (1-an3); and n0 is preferably 0 or 1, and wherein Y1 represents a single bond or —SO2—; R5 represents a linear or branched monovalent hydrocarbon group of 1 to 10 carbon atoms, cyclic monovalent hydrocarbon group of 3 to 20 carbon atoms or monovalent hydrocarbon group of 3 to 20 carbon atoms having a cyclic partial structure which may be substituted with a fluorine atom; and M+ represents an organic caType: GrantFiled: April 18, 2012Date of Patent: April 14, 2015Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Yoshitaka Komuro, Yoshiyuki Utsumi, Akiya Kawaue, Masatoshi Arai
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Patent number: 8980795Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.Type: GrantFiled: April 25, 2012Date of Patent: March 17, 2015Assignee: King Abdullah University of Science and TechnologyInventors: Salim Al-Babili, Adrian Alder
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Publication number: 20140287924Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.Type: ApplicationFiled: April 25, 2012Publication date: September 25, 2014Inventors: Salim Al-Babili, Adrian Alder
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Patent number: 8822383Abstract: Provided is a novel compound which can germinate seeds of root parasitic plants, more specifically, a compound represented by the formula: wherein R1, R2, R3, R4, and R5 are the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group, or R1 and R2 are linked together to form a lower alkylenedioxy group, or R1 and R2 together with the adjacent carbon atoms form a benzene ring, or R2 and R3 are linked together to form a lower alkylenedioxy group, or R2 and R3 together with the adjacent carbon atoms form a benzene ring, R6 represents a hydrogen atom or a lower alkyl group, X and Y are the same or different and each represents an oxygen atom and a sulfur atom, and n represents an integer of 0, 1 or 2, and a method for controlling root parasitic plants.Type: GrantFiled: March 30, 2011Date of Patent: September 2, 2014Assignees: National University Corporation KOBE UNIVERSITY, Sumitomo Chemical Company, LimitedInventors: Mitsuru Sasaki, Yukihiro Sugimoto, Hirosato Takikawa, Hideyoshi Miyake, Noritada Matsuo
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Publication number: 20140220492Abstract: A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, including a base component containing a polymeric compound having a structural unit derived from a compound represented by general formula (a0-1). R1 and R2 each independently represents a group represented by general formula (a0-2) or a functional group; V1 and V2 each represents a single bond or an alkylene group of C1 to C10 which may have a substituent; Y1 represents a single bond or a divalent linking group; Y2 represents a fluorinated alkylene group of C1 to C4 which may have a substituent; L1 represents O or a group represented by —NR?1—(R?1 represents H or an alkyl group of C1 to C5); Mm+ represents an organic cation having a valency of m; and m represents an integer of 1 or more.Type: ApplicationFiled: February 3, 2014Publication date: August 7, 2014Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Takaaki Kaiho, Yoshitaka Komuro
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Publication number: 20140147481Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.Type: ApplicationFiled: June 3, 2011Publication date: May 29, 2014Applicants: UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: William Gerwick, Lena Gerwick, Huykjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
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Publication number: 20140148604Abstract: Process for preparing sodium or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters, comprising the reaction of a malonic ester with potassium hydroxide to give the corresponding malonic ester potassium salt of the formula (III) which is then reacted further with a chloroacetic ester to give a compound of the formula (V) followed by a ring closure reaction in which the compound of the formula (V) is reacted with a sodium or potassium alkoxide of the formula ZOR1 where R1, R2, R3 and K are each as defined in the description.Type: ApplicationFiled: February 29, 2012Publication date: May 29, 2014Applicant: Bayer Intellectual Property GmbHInventors: Christian Funke, Taraneh Farida, Stefan Beeck, Norbert Lui, Berndt Maiwald
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Publication number: 20140011845Abstract: Disclosed are cyclic dione derivatives represented by formula (I), wherein the substituents are as defined in the description. The preparation method, intermediate and use thereof are also provided.Type: ApplicationFiled: December 30, 2011Publication date: January 9, 2014Applicant: SYNGENTA PARTICIPATIONS AGInventors: Stephane Andre Marie Jeanmart, Long Lu, Yaming Wu, Lisheng Mao, Michel Muehlbeach
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Publication number: 20130085068Abstract: Provided is a novel compound which can germinate seeds of root parasitic plants, more specifically, a compound represented by the formula: wherein R1, R2, R3, R4, and R5 are the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group, or R1 and R2 are linked together to form a lower alkylenedioxy group, or R1 and R2 together with the adjacent carbon atoms form a benzene ring, or R2 and R3 are linked together to form a lower alkylenedioxy group, or R2 and R3 together with the adjacent carbon atoms form a benzene ring, R6 represents a hydrogen atom or a lower alkyl group, X and Y are the same or different and each represents an oxygen atom and a sulfur atom, and n represents an integer of 0, 1 or 2, and a method for controlling root parasitic plants.Type: ApplicationFiled: March 30, 2011Publication date: April 4, 2013Applicants: SUMITOMO CHEMICAL COMPANY, LIMITED, National University Corporation KOBE UNIVERSITYInventors: Mitsuru Sasaki, Yukihiro Sugimoto, Hirosato Takikawa, Hideyoshi Miyake, Noritada Matsuo
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Patent number: 8318955Abstract: Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates of the formula (I) and/or (I?) comprising the reaction of a haloacetyl chloride compound of the formula (II) with a malonic ester of the formula (III) in which Hal, R1 and R2 have the definitions stated in the application, in the presence of a suitable base and optionally in the presence of a solvent; the addition of a sufficient amount of water to the reaction mixture; and the isolation of the desired 2,4-dioxotetrahydrofuran-3-carboxylate.Type: GrantFiled: August 11, 2010Date of Patent: November 27, 2012Assignee: Bayer Cropscience AGInventors: Norbert Lui, Jens-Dietmar Heinrich, Christian Funke
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Publication number: 20120276546Abstract: A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.Type: ApplicationFiled: June 21, 2012Publication date: November 1, 2012Applicant: Kao CorportationInventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
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Patent number: 7927780Abstract: A compound represented by formula (I); and a compound represented by formula (b1-1): wherein X represents —O—, —S—, —O—R3— or —S—R4—, wherein each of R3 and R4 independently represents an alkylene group of 1 to 5 carbon atoms; R2 represents an alkyl group of 1 to 6 carbon atoms, an alkoxy group of 1 to 6 carbon atoms, a halogenated alkyl group of 1 to 6 carbon atoms, a halogen atom, a hydroxyalkyl group of 1 to 6 carbon atoms, a hydroxyl group or a cyano group; a represents an integer of 0 to 2; Q1 represents an alkylene group of 1 to 12 carbon atoms or a single bond; Y1 represents an alkylene group of 1 to 4 carbon atoms or a fluorinated alkylene group; M+ represents an alkali metal ion; and A+ represents an organic cation.Type: GrantFiled: September 10, 2008Date of Patent: April 19, 2011Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Akiya Kawaue, Takeshi Iwai, Hideo Hada, Shinichi Hidesaka, Tsuyoshi Kurosawa, Natsuko Maruyama, Kensuke Matsuzawa, Takehiro Seshimo, Hiroaki Shimizu, Tsuyoshi Nakamura
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Publication number: 20110060147Abstract: Process for preparing 2,4-dioxotetrahydrofuran-3-carboxylates of the formula (I) and/or (I?) comprising the reaction of a haloacetyl chloride compound of the formula (II) with a malonic ester of the formula (III) in which Hal, R1 and R2 have the definitions stated in the application, in the presence of a suitable base and optionally in the presence of a solvent; the addition of a sufficient amount of water to the reaction mixture; and the isolation of the desired 2,4-dioxotetrahydrofuran-3-carboxylate.Type: ApplicationFiled: August 11, 2010Publication date: March 10, 2011Applicant: Bayer CropScience AGInventors: Norbert Lui, Jens-Dietmar Heinrich, Christian Funke
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Publication number: 20100316954Abstract: Disclosed is a novel monomer having a lactone skeleton, which is useful typically as a monomer component typically for a highly functional polymer, because, when the monomer is applied typically to a resist resin, the resin is satisfactory stable and resistant typically to chemicals, is highly soluble in organic solvents, and has improved hydrolyzability and/or water solubility after hydrolysis. The monomer having a lactone skeleton is represented by following Formula (1), wherein Ra represents a hydrogen atom, halogen atom, or substituted or unsubstituted alkyl group having 1 to 6 carbon atoms; R1 represents a group having a lactone skeleton; and Y represents a bivalent organic group having 1 to 6 carbon atoms.Type: ApplicationFiled: January 21, 2009Publication date: December 16, 2010Inventors: Hiroshi Koyama, Mari Sumida, Hiroki Tanaka
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Patent number: 7838693Abstract: The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-?-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.Type: GrantFiled: December 11, 2007Date of Patent: November 23, 2010Assignee: Hoffmann-La Roche Inc.Inventors: Miall Cedilote, Thomas Cleary, Hans Iding, Pingsheng Zhang
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Patent number: 7759044Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.Type: GrantFiled: January 25, 2008Date of Patent: July 20, 2010Assignee: International Business Machines CorporationInventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
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Publication number: 20100050719Abstract: The present invention concerns the field of bacterial biocontrol. More precisely, the invention relates to the identification of chemicals which promote the growth of bacteria inactivating NAHL, such as gamma-caprolactone (GCL) and 4-heptanolide (HTN) and their use in soil additives.Type: ApplicationFiled: January 18, 2008Publication date: March 4, 2010Inventors: Denis Faure, Amélie Cirou, Yves Dessaux
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Publication number: 20080103191Abstract: Pharmaceutical composition comprising one or more entacapone derivatives and one or more pharmaceutically acceptable carriers, a process for producing the pharmaceutical composition, specific entacapone derivatives, a process for the preparation of entacapone derivatives, and the use of the entacapone derivatives for the preparation of a medicament.Type: ApplicationFiled: June 14, 2007Publication date: May 1, 2008Inventors: Klaus Hansen, Robert Kraemer, Thomas Lauterbach, Dirk Schmidt, Fritz Paar, Petra Pfeiffer, Detlef Geffken, Wolfgang Thimann, Katharina Wehner
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Patent number: 7026351Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.Type: GrantFiled: March 20, 2003Date of Patent: April 11, 2006Assignee: Xenoport, Inc.Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
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Patent number: 6838128Abstract: The invention relates to chiral nonracemic liquid crystal compounds which are useful as components in liquid crystal compositions to impart high polarization to the mixture. The materials of this invention can be combined with liquid crystal host materials to impart improved properties to mixtures. Chiral nonracemic compounds of this invention can function as additives or dopants in host materials to impart chirality into an LC material.Type: GrantFiled: February 5, 2002Date of Patent: January 4, 2005Assignee: Displaytech, Inc.Inventors: Michael Wand, Xin Hua Chen
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Patent number: 6828276Abstract: There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radicals, X1 is a hetero atom, X2 is a chain of carbon atoms, L is a chain-like element, R1, R2, R3, R4, R5 are various radicals, and Y and Z are monoatomic bridge elements.Type: GrantFiled: August 30, 2001Date of Patent: December 7, 2004Assignee: Aventis CropScience GmbHInventors: Thomas Seitz, Andreas van Almsick, Lothar Willms, Hermann Bieringer, Thomas Auler, Hubert Menne
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Patent number: 6489492Abstract: The present invention relates to a novel chiral derivative of Garcinia acid bearing lactone ring moiety of formula I, wherein: R1=R3=alkali salt of carboxyl acid, or acid chloride or lower esters or part of N-substituted cyclic imides. R2=hydroxyl or protected hydroxyl group and a process for preparing the same.Type: GrantFiled: September 5, 2001Date of Patent: December 3, 2002Assignee: Department of Science and TechnologyInventors: Ibrahim Ibnu Saud, Grace Thomas, Paleappadam Vavan Sasi
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Patent number: 6486196Abstract: The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I).Type: GrantFiled: May 4, 2001Date of Patent: November 26, 2002Assignee: Dr. Reddy's Research FoundationInventors: Srinivas Nanduri, Sairam Pothukuchi, Sriram Rajagopal, Venkateswarlu Akella, Sunilkumar Bhadramma Kochunarayana Pillai, Ranjan Chakrabarti
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Publication number: 20020133028Abstract: In industrial production of &ohgr;-hydroxyaliphatic acid being an important intermediate for large cyclic lactone-based perfumes, using dicarboxylate ester which is inexpensive and readily obtainable, a method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided.Type: ApplicationFiled: January 14, 2002Publication date: September 19, 2002Applicant: Soda Aromatic Co., Ltd.Inventors: Hideaki Takaoka, Sigeru Wada, Nobuhiko Ito, Akio Hasebe, Shinzo Imamura, Hideo Muraoka
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Patent number: 6395724Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.Type: GrantFiled: June 7, 1999Date of Patent: May 28, 2002Assignee: Advanced Medicine, Inc.Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin
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Patent number: 6388101Abstract: Proposed is a chemical-sensitization positive-working photoresist composition for photolithographic patterning in the manufacture of semiconductor devices having high transparency even to ultraviolet light of very short wavelength such as ArF excimer laser beams of 193 nm wavelength to exhibit high photosensitivity and capable of giving a patterned resist layer with high pattern resolution. The composition comprises (A) a resinous ingredient which is subject to an increase of the solubility in an aqueous alkaline developer solution in the presence of an acid and (B) a radiation-sensitive acid-generating compound. Characteristically, the resinous ingredient as the component (A) is a (meth)acrylic copolymer of which from 20% to 80% by moles of the monomeric units are derived from a (meth)acrylic acid ester of which the ester-forming group has a specific oxygen-containing heterocyclic ring structure.Type: GrantFiled: May 2, 2000Date of Patent: May 14, 2002Assignee: Tokyo Ohka Kogyo Co., Ltd.Inventors: Hideo Hada, Kazufumi Sato, Hiroshi Komano
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Publication number: 20020010341Abstract: The use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis is provided.Type: ApplicationFiled: April 17, 2001Publication date: January 24, 2002Inventors: Gebre-mariam Mesfin, Richard K. Jensen
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Publication number: 20010051734Abstract: In industrial production of &ohgr;-hydroxyaliphatic acid being an important intermediate for large cyclic lactone-based perfumes, using dicarboxylate ester which is inexpensive and readily obtainable, a method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided.Type: ApplicationFiled: June 28, 2001Publication date: December 13, 2001Applicant: Soda Aromatic Co., Ltd.Inventors: Hideaki Takaoka, Sigeru Wada, Nobuhiko Ito, Akio Hasebe, Shinzo Imamura, Hideo Muraoka
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Patent number: 6313321Abstract: The present invention provides a process for preparing &bgr;-hydroxy-&ggr;-butyrolactone or &bgr;-methyl-&bgr;-hydroxy-&ggr;-butyrolactone represented by the formula (1): wherein R1 is hydrogen or methyl, which entails a) cyanating glycidol or 2-methyl-2,3-epoxypropanol, b) hydrolyzing the product of step a), and c) lactonizing the product of step b).Type: GrantFiled: June 26, 2000Date of Patent: November 6, 2001Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Naoshi Murata, Kunihiko Sakano, Tetsuya Ikemoto
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Patent number: 6271180Abstract: The present invention relates to novel compounds of the formula (I) in which Het represents one of the groups in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, and to their use as pesticides and herbicides.Type: GrantFiled: April 14, 2000Date of Patent: August 7, 2001Assignee: Bayer AktiengesellschaftInventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
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Patent number: 6225288Abstract: Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.Type: GrantFiled: March 16, 2000Date of Patent: May 1, 2001Assignee: Merk Frosst Canada & Co.Inventors: Yongxin Han, Andre Giroux, Erich Grimm, Renee Aspiotis, Sebastien Francoeur, Robert Zamboni, Petpiboon Prasit, Christopher Bayly, Dan McKay, Cameron Black
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Patent number: 6166070Abstract: Kodaistatins A and B, compounds of the molecular formula C.sub.35 H.sub.34 O.sub.11, and Kodaistatins C and D, compounds of the molecular formula C.sub.35 H.sub.34 O.sub.12, have antidiabetic activity.Type: GrantFiled: October 18, 1999Date of Patent: December 26, 2000Assignee: Aventis Pharma Deutschland GmbHInventors: Nirogi Venkata Satya Ramakrishna, Keshavapura Hosamane Sreedhara Swamy, Erra Koreswara Satya Vijayakumar, Suresh Rudra Nadkarni, Kenia Jayvanti, Andreas Herling, Herbert Kogler, Laszlo Vertesy, Rajan Mukund Panshikar, Kota Sridevi, Mythili Raman, Roda Maneck Dalal
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Patent number: 6147228Abstract: A process for the isolation of Garcinia acid from the fresh or dried rinds of the fruits of Garcinia indica, Garcinia cambogia and/or Garcinia atroviridis.Type: GrantFiled: July 30, 1999Date of Patent: November 14, 2000Assignee: Department of Science and Technology Government of IndiaInventors: Ibrahim Ibnusaud, Tom Thomas Puthiaparampil, Beena Thomas
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Patent number: 6100292Abstract: This invention relates to ketones represented by the following formula ##STR1## and to drugs in which such a ketone or pharmacologically acceptable salt thereof is an effective component.The ketones of the present invention encourage the production of platelets, red blood cells, white blood cells and the like, and can be used to prevent or treat cytopaenia brought about by cancer chemotherapy, radiotherapy, bone marrow transplantation and drug therapy, or by immunological abnormality or anaemia, and the like.Type: GrantFiled: May 25, 1999Date of Patent: August 8, 2000Assignee: Toray Industries, Inc.Inventors: Tsuyoshi Matsumoto, Hideki Kawai, Kiyoshi Okano, Katsuyuki Mori, Yasumoto Adachi
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Patent number: 6060046Abstract: An antifouling composition that comprises an effective amount of a furanone of the structure shown and a suitable carrier therefor. In the figure, substituents R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom, a hydroxyl group, an alkyl group containing from 1 to 10 carbon atoms, an ether group containing from 1 to 10 carbon atoms, an ester group containing from 1 to 10 carbon atoms or a halogenated alkene containing from 1 to 10 carbon atoms or R.sub.2 and R.sub.3 together may comprise an unsubstituted or a halogenated alkene containing from 1 to 10 carbon atoms and R.sub.4 is a hydrogen or halogen atom, and a suitable carrier therefor.Type: GrantFiled: February 18, 1997Date of Patent: May 9, 2000Assignee: Unisearch LimitedInventors: Peter D. Steinberg, Peter C. De Nys
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Patent number: 6017951Abstract: Novel nonpeptides characterized as having a carbamic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds are useful in treating elevated levels of endothelin and are therefore useful in the treatment of hypertension, myocardial infarction, diabetes, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythminas, asthma, chronic and acute renal failure, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, stroke, head injury, and ischemic bowel syndrome.Type: GrantFiled: February 10, 1999Date of Patent: January 25, 2000Assignee: Warner-Lambert CompanyInventors: William C. Patt, Bill R. Reisdorph, Joseph T. Repine
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Patent number: 5998408Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.Type: GrantFiled: October 8, 1997Date of Patent: December 7, 1999Assignee: Merck & Co., Inc.Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, Andrew Kotliar, William H. Parsons, Kathleen M. Rupprecht
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Patent number: 5922759Abstract: Novel nonpeptides characterized as having a carbarimic group which are antagonists of endothelin I are described, as well as methods for their preparation and pharmaceutical compositions containing the same. The compounds as useful in treating elevated levels of endothelin and are therefore used in the treatment of hypertension, myocardial infarction, diabetes, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, chronic and acute renal failure, preeclamnpsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, stroke, head injury, and ischemic bowel syndrome.Type: GrantFiled: December 15, 1997Date of Patent: July 13, 1999Assignee: Warner-Lambert CompanyInventors: William C. Patt, Bill R. Reisdorph, Joseph T. Repine
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Patent number: 5905090Abstract: Analogues of the active metabolite of leflunomide, and to the use thereof as immunosuppressive and/or antinflammatory agents.Type: GrantFiled: April 29, 1998Date of Patent: May 18, 1999Assignee: Italfarmaco S.p.A.Inventors: Giorgio Bertolini, Mauro Biffi, Flavio Leoni, Maria Letizia Marchetti, Jacques Mizrahi, Flavio Somenzi, Paolo Mascagni
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Patent number: 5869524Abstract: This invention provides compounds of formula 1 having the structure ##STR1## wherein: R.sup.1 is hydrogen, halogen, alkyl, alkoxy, fluoroalkoxy, trifluoromethyl, alkylthio, or SCF.sub.3R.sup.2 and R.sup.3 are each independently, hydrogen or alkyl, or R.sup.2 and R.sup.3 may be taken together to form a saturated cycloalkyl ring; andR.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are each independently, hydrogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, halogen, fluoroalkoxy, CF.sub.3, or SCF.sub.3 which are useful in the treatment of arthritic disorders, colorectal cancer, and Alzheimer's disease.Type: GrantFiled: October 28, 1997Date of Patent: February 9, 1999Assignee: American Home Products CorporationInventor: Amedeo A. Failli
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Patent number: 5849217Abstract: An optically active compound represented by the formula R.sub.1 --A.sub.1 --A.sub.2 --X.sub.1 --A.sub.3 --(CH.sub.2).sub.p --L--A.sub.4 --R.sub.2, in which R.sub.1 is F, CN or straight chain, branched or cyclic alkyl and R.sub.2 is H, F, CH or straight chain or branched alkyl; A.sub.3 is 1,4-phenylene, pyridine-2,5-diyl, pyrimidine-2,5-diyl, pyrazine-2,5-diyl, pyridazine-3,6-diyl, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3-ditiane-2,5-diyl, thiophene-2,5-diyl, thiazole-2,5-diyl, thiaziazole-2,5-diyl, benzoxazole-2,5-diyl, benzoxazole-2,6-diyl, benzothiazole-2,5-diyl, benzothiazole-2,6-diyl, benzofuran-2,5-diyl, benzofuran-2,6-diyl, quinoxaline-2,6-diyl, quinoline-2,6-diyl, 2,6-naphthylene, indane-2,5-diyl, 2-alkylindane-2,5-diyl, indanone-2,6-diyl, 2-alkylindane-2,6-diyl, coumarane-2,5-diyl and 2-alkylcoumarane-2,5-diyl; A.sub.1, A.sub.2 and A.sub.4 are single bond or A.sub.3 ; X.sub.1 ' is a single bond, --COO--, --OCO--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.Type: GrantFiled: November 13, 1996Date of Patent: December 15, 1998Assignee: Canon Kabushiki KaishaInventors: Shinichi Nakamura, Takao Takiguchi, Takashi Iwaki, Takeshi Togano, Yoko Kosaka
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Patent number: 5714484Abstract: Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a first portion which targets a desired cysteine protease and positions the inhibitor near the thiolate anion portion of the active site of the protease, and a second portion which covalently bonds to the cysteine protease and irreversibly deactivates that protease by providing a carbonyl or carbonyl-equivalent which is attacked by the thiolate anion of the active site of the cysteine protease to sequentially cleave a .beta.-dicarbonyl enol ether leaving group.Type: GrantFiled: June 7, 1995Date of Patent: February 3, 1998Assignee: Prototek, Inc.Inventors: Mary P. Zimmerman, Robert E. Smith, Mark Becker
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Patent number: 5691373Abstract: Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.Type: GrantFiled: February 6, 1995Date of Patent: November 25, 1997Assignee: Warner-Lambert CompanyInventors: Kent Alan Berryman, Annette Marian Doherty, Jeremy John Edmunds, William Chester Patt, Mark Stephen Plummer, Joseph Thomas Repine
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Patent number: 5691374Abstract: The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.Type: GrantFiled: May 18, 1995Date of Patent: November 25, 1997Assignee: Merck Frosst Canada Inc.Inventors: Cameron Black, Erich Grimm, Zhaoyin Wang, Serge Leger
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Patent number: 5610122Abstract: The present invention relates to a new 3-aryl-4-hydroxy-.DELTA..sup.3 -dihydrofuranone derivatives of the general formula (I) ##STR1## in which the radicals A, B, G, X, Y, Z and n have the meaning given in the description, to a plurality of processes for their preparation, and to their use as pesticides.Type: GrantFiled: September 9, 1994Date of Patent: March 11, 1997Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Thomas Bretschneider, Bernd-Wieland Kr uger, Hans-Joachim Santel, Markus Dollinger, Ulrike Wachendorff-Neumann, Christoph Erdelen
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Patent number: 5596124Abstract: There is provided a method for safening herbicides in cereal crop plants by using 5-aryloxy-1,2 -(disubstituted)benzene compounds of formula I ##STR1## Further provided are compositions comprising a 5-aryloxy-1,2-(disubstituted)benzene compound of formula I.Type: GrantFiled: December 9, 1994Date of Patent: January 21, 1997Assignee: American Cyanamid CompanyInventors: Gail E. Cary, Peter J. Wepplo, Barbara A. Bench