Additional Chalcogen Bonded Directly To The Lactone Ring Patents (Class 549/313)
  • Patent number: 11611041
    Abstract: The present disclosure provides an organic thin film and a method for preparing the same, a display device, and an optical device, in which the method includes: providing a base substrate; forming an isomerization generating layer on the base substrate, the isomerization generating layer including a first region and a second region; adding a precursor solution on a surface of the isomerization generating layer away from the base substrate, and allowing surface energy of the second region to be greater than surface energy of the first region, so as to form the organic thin film from the precursor solution, the precursor solution being at least partially located in the second region.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: March 21, 2023
    Assignees: HEFEI BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Xun Gu, Wenjuan Mei, Dan Liu, Baochao Li, Changjun Zhang
  • Patent number: 11434182
    Abstract: A process for the oligomerization of C3- to C5-olefins proceeds in the presence of a catalyst, wherein the oligomerization is carried out in at least one reaction stage which includes at least one reactor and at least one distillation column. The content of oligomers in the feed stream to the at least one reaction stage after removal of the oligomers in the at least one distillation column is less than 0.4% by weight.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: September 6, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Guido Stochniol, Stephan Peitz, Fabian Nadolny, Benjamin William Berntsson, Helene Reeker, Reiner Bukohl, Niklas Paul
  • Patent number: 11332421
    Abstract: The present invention relates to a process for oligomerization of C2- to C8-olefins in at least two reaction stages, wherein in the last distillation column the reaction mixture is fractionated such that only very small amounts of the reactant olefins and the analogous alkanes remain in the bottom of the distillation column.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: May 17, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Stephan Peitz, Guido Stochniol, Armin Matthias Rix, Niklas Paul, Tatina Valèrie Six
  • Patent number: 10793488
    Abstract: A process is used for oligomerizing C2- to C8-olefins in several reaction stages in which the starting mixture and the respective outputs from the reaction stages are separated and are fed to different reaction stages.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: October 6, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Guido Stochniol, Jörg Schallenberg, Stephan Peitz
  • Patent number: 9802911
    Abstract: A method of photooxygenating furfural in a photooxygenating system, whereby a liquid mixture comprising furfural, a photosensitizer, and a reaction solvent is passed through a reaction section of the photooxygenating system, wherein the liquid mixture is exposed to solar radiation, while a portion of the furfural is oxidized in presence of the photosensitizer and a furanone compound is produced. Various embodiments of the photocatalytic water splitting reactor, and the water splitting system are also provided.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: October 31, 2017
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Chanbasha Basheer, Ahmed Abdi Hassan
  • Patent number: 9751849
    Abstract: A method of photooxygenating furfural in a photooxygenating system, whereby a liquid mixture comprising furfural, a photosensitizer, and a reaction solvent is passed through a reaction section of the photooxygenating system, wherein the liquid mixture is exposed to solar radiation, while a portion of the furfural is oxidized in presence of the photosensitizer and a furanone compound is produced. Various embodiments of the photocatalytic water splitting reactor, and the water splitting system are also provided.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: September 5, 2017
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Chanbasha Basheer, Ahmed Abdi Hassan
  • Patent number: 9308527
    Abstract: This describes bidentate ferrocene-linked phosphine-phosphoramidate compounds. Hydroformylation catalyst compositions and methods of hydroformylation using the compounds are also disclosed. Methods of making the compounds are also disclosed.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: April 12, 2016
    Assignee: Eastman Chemical Company
    Inventors: Rebecca How, Matt Clarke, Robert Thomas Hembre, James A. Ponasik, Ginette S. Tolleson
  • Publication number: 20150119458
    Abstract: The present invention discloses a 4-((substituted phenyl)difluoromethyl)phenoxycarboxylic acid derivative and preparation process and use thereof. More specifically, the present invention relates to a compound of the following formula I, which is defined in the specification. The compounds according to the present invention can be used as PPAR agonists, and demonstrates a strong effect on reducing the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) in blood plasma, and thus the compound according to the present invention can be used in the preparation of a medicament for treating or preventing hyperlipoidemia or cardio-cerebrovascular diseases caused by hyperlipoidemia, such as diabetes, atherosclerosis, stroke, coronary heart disease, etc. The present invention also relates to a novel intermediate compound for the preparation of the compound of formula I and preparation method thereof.
    Type: Application
    Filed: April 25, 2013
    Publication date: April 30, 2015
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Hua Bai, Jian Hong, Lifeng Cai, Hegeng Wei, Xiaoyu Liu, Xiaohe Zheng
  • Patent number: 8980795
    Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: March 17, 2015
    Assignee: King Abdullah University of Science and Technology
    Inventors: Salim Al-Babili, Adrian Alder
  • Patent number: 8981123
    Abstract: A compound represented by the following General Formula (1): where R1 represents a protective group for a hydroxyl group or a hydrogen atom, and R2 represents a methyl group or an ethyl group.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: March 17, 2015
    Assignee: Microbial Chemistry Research Foundation
    Inventors: Masakatsu Shibasaki, Naoya Kumagai
  • Patent number: 8946453
    Abstract: Disclosed are cyclic dione derivatives represented by formula (I), wherein the substituents are as defined in the description. The preparation method, intermediate and use thereof are also provided.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: February 3, 2015
    Assignee: Syngenta Participations AG
    Inventors: Stephane Andre Marie Jeanmart, Long Lu, Yaming Wu, Lisheng Mao, Michel Muehlebach
  • Publication number: 20140364629
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Application
    Filed: March 5, 2014
    Publication date: December 11, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • Publication number: 20140296539
    Abstract: A compound represented by the following General Formula (1): where R1 represents a protective group for a hydroxyl group or a hydrogen atom, and R2 represents a methyl group or an ethyl group.
    Type: Application
    Filed: June 11, 2014
    Publication date: October 2, 2014
    Inventors: Masakatsu SHIBASAKI, Naoya KUMAGAI
  • Publication number: 20140287924
    Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.
    Type: Application
    Filed: April 25, 2012
    Publication date: September 25, 2014
    Inventors: Salim Al-Babili, Adrian Alder
  • Patent number: 8822706
    Abstract: The invention relates to a method for preparing 2-hydroxybutyrolactone (2HBL) from a compound or its salt or its oligomers, said compound fitting formula (I) CH3—S—CH2CH2CR1R2R3 Wherein R1 represents H R2 represents a group selected from OH; OR4 and OCOR4 wherein R4 represents a group selected from linear, cyclic, alicyclic or branches alkyl groups having from 1 to 10 carbon atoms, and aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, halogens and hydroxyl, amino, nitro and alkoxy groups having from 1 to 10 carbon atoms; and OSiRR?R? wherein R, R? and R? are selected independently of each other from linear, cyclic, alicyclic or branched alkyl groups having from 1 to 10 carbon atoms, aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, or R1 and R2 represent together ?O, R3 r
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: September 2, 2014
    Assignee: Adisseo France S.A.S.
    Inventors: Vivien Henryon, Jerome Monbrun
  • Publication number: 20140194632
    Abstract: Natural and synthetic compounds of Formulae Ia-Ie having a lactone structure, in particular Securolide, have been determined to be effective anti-tumor compounds which target the hrad9 gene and/or protein encoded thereby or complex containing the protein and/or the p53 gene and/or protein. Securolide is cytoselective for mutants of hRad9 based on studies conducted in Rad9 mutant yeast strains. Securolide appears to interact with mutant hRad9 in cancer cells to produce DNA lesions which result in apoptosis. Studies have demonstrated that Securolide is useful for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer, and to alleviate pain associated with the cancer.
    Type: Application
    Filed: August 5, 2013
    Publication date: July 10, 2014
    Applicant: Magnachem International Laboratories, Inc.
    Inventors: Federico M. Gomez, C. Federico Gomez Garcia-Godoy, David Terrero
  • Publication number: 20140186769
    Abstract: A resist composition having excellent lithography properties, which generates an acid upon exposure and exhibits changed solubility in a developing solution by the action of an acid, the resist composition containing a base material component (A) which exhibits changed solubility in a developing solution by the action of an acid, and the base material component (A) containing a high-molecular weight compound (A1) having a constituent unit (a0) derived from a compound represented by the following general formula (a0-1); a method for forming a resist pattern using the resist composition; and a high-molecular weight compound (A1) having a constituent unit (a0) derived from a compound represented by the following general formula (a0-1), are disclosed.
    Type: Application
    Filed: December 10, 2013
    Publication date: July 3, 2014
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Takaaki Kaiho, Yoshiyuki Utsumi, Jun Iwashita, Masahito Yahagi
  • Publication number: 20140178821
    Abstract: A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, including a base component (A) which exhibits changed solubility in a developing solution under action of acid, and a photo-decomposable quencher (D0) containing a compound represented by general formula (d0) shown below. In the formula, R1 represents a hydrocarbon group of 4 to 20 carbon atoms which may have a substituent; Y1 represents a single bond or a divalent linking group; R2 and R3 each independently represents a substituent of 0 to 20 carbon atoms other than a fluorine atom; one of R2 and R3 may form a ring with Y1; Mm+ represents an organic cation having a valency of m; and m represents an integer of 1 or more.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 26, 2014
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Akiya Kawaue, Takaaki Kaiho, Tsuyoshi Nakamura
  • Patent number: 8669379
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: March 11, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • Publication number: 20140058021
    Abstract: A composition, which comprises a) an organic material susceptible to oxidative, thermal or light-induced degradation; and b) a compound of formula I (Formula I) (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently from each other H, C1-C8-alkyl, C4-C8-cycloalkyl, phenyl, C1-C4-alkoxy or halogen; n is 1, 2, 3, or 4; and when n is 1 A is —C(=0)-OR?1, —C(=0)-N(R?2)(R?3), —CN, phenyl, which is unsubstituted or substituted by one or more C1-C8-alkyl, C4-C8-alkoxy, C5-C7-cycloalkyl or halogen, —H or —S02-phenyl; when n is 2 A is —C(=0)-O—Z1—O—C(=0)-, —C(=0)-N(R?1)—Z2—N(R?2)—C(=0)- or piperazine-N,N?-biscarbonyl.
    Type: Application
    Filed: April 25, 2012
    Publication date: February 27, 2014
    Applicant: BASF SE
    Inventors: Walter Fischer, Abdel-Ilah Basbas, Kai-Uwe Schoning, Cinzia Tartarini, Werner Holzl, Bruno Rotzinger
  • Publication number: 20130267474
    Abstract: The present invention describes phytochemicals present in maple syrup and maple tree extracts by butanol, ethyl acetate and methanol. Novel compounds are isolated from maple syrups, including one compound Quebecol generated in the maple syrup manufacturing process. Also described are digesting extract of maple syrup. The phytochemicals may be used for the treatment or prevention of cancers, metabolic syndromes, diabetes, microorganism infections and/or antioxidants.
    Type: Application
    Filed: August 19, 2011
    Publication date: October 10, 2013
    Applicants: UNIVERSITY OF RHODE ISLAND, FÉDÉRATION DES PRODUCTEURS ACÉRICOLES DU QUÉBEC
    Inventors: Navindra P. Seeram, Liya Li, Geneviéve Béland, Julie Barbeau
  • Patent number: 8546444
    Abstract: Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. Initial studies have shown that patients can be taken off of morphine when the preferred alpha-methylene-gamma-butyrolactone is administered in a dosage of between 60 and 120 mg/day intramuscularly.
    Type: Grant
    Filed: May 28, 2012
    Date of Patent: October 1, 2013
    Assignee: Magnachem International Laboratories, Inc.
    Inventors: Federico M. Gomez, C. Federico Gomez Garcia-Godoy
  • Publication number: 20130217898
    Abstract: The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ?-caprolactone was obtained at an isolated yield of 82%.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 22, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Kazuaki Ishihara, Muhammet Uyanik
  • Publication number: 20130203688
    Abstract: The present document describes a nutraceutical or cosmeceutical composition for the prophylaxis of an ailment comprising a therapeutically effective amount of a sugar plant syrup filtration residue in association with a pharmaceutically acceptable carrier. The present document also describes a nutraceutical or cosmeceutical composition for improving health condition of skin. The present document describes a method of producing a sugar plant syrup-derived product; wherein the improvement is characterized in the step of: collecting a sugar plant syrup residue during the production of sugar or syrup to produce a syrup-derived by-product.
    Type: Application
    Filed: August 19, 2011
    Publication date: August 8, 2013
    Applicant: FÉDÉRATION DES PRODUCTEURS ACÉRI-COLES DU QUÉBEC
    Inventors: Julie Barbeau, Geneviève Béland
  • Publication number: 20130204016
    Abstract: The invention relates to a method for preparing 2-hydroxybutyrolactone (2HBL) from a compound or its salt or its oligomers, said compound fitting formula (I) CH3—S—CH2CH2CR1R2R3 Wherein R1 represents H R2 represents a group selected from OH; OR4 and OCOR4 wherein R4 represents a group selected from linear, cyclic, alicyclic or branches alkyl groups having from 1 to 10 carbon atoms, and aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, halogens and hydroxyl, amino, nitro and alkoxy groups having from 1 to 10 carbon atoms; and OSiRR?R? wherein R, R? and R? are selected independently of each other from linear, cyclic, alicyclic or branched alkyl groups having from 1 to 10 carbon atoms, aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, or R1 and R2 represent together ?O, R3
    Type: Application
    Filed: October 17, 2011
    Publication date: August 8, 2013
    Applicant: ADISSEO FRANCE S.A.S.
    Inventors: Vivien Henryon, Jerome Monbrun
  • Patent number: 8501431
    Abstract: Natural and synthetic compounds of Formulae Ia-Ie having a lactone structure, in particular Securolide, have been determined to be effective anti-tumor compounds which target the hrad9 gene and/or protein encoded thereby or complex containing the protein and/or the p53 gene and/or protein. Securolide is cytoselective for mutants of hRad9 based on studies conducted in Rad9 mutant yeast strains. Securolide appears to interact with mutant hRad9 in cancer cells to produce DNA lesions which result in apoptosis. Studies have demonstrated that Securolide is useful for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer, and to alleviate pain associated with the cancer.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: August 6, 2013
    Assignee: Magnachem International Laboratories, Inc.
    Inventors: David Terrero, Federico M. Gomez, C. Federico Gomez Garcia-Godoy
  • Patent number: 8492539
    Abstract: The present invention provides (i) processes for preparing a 2?-deoxy-2?-fluoro-2?-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2?-deoxy-2?-fluoro-2?-C-methyl-?-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: July 23, 2013
    Assignee: Gilead Pharmasset LLC
    Inventors: Byoung-Kwon Chun, Peiyuan Wang, Jinfa Du, Suguna Rachakonda
  • Publication number: 20130035304
    Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 31, 2011
    Publication date: February 7, 2013
    Inventors: Loren D. Walensky, Michelle L. Stewart, Nicole Cohen
  • Patent number: 8367720
    Abstract: The present invention relates to an andrographolide derivative of the formula (I), wherein R1, R2 and R3 are same or different substituents selected from hydrogen, substituted or unsubstituted organic acid radicals, inorganic acid radicals, alkyl, aryl or heteroaryl, and at least one of R1, R2 and R3 is R-lipoic acid, S-lipoic acid or a mixture thereof, or corresponding dihydrolipoic acids thereof, or N-acetylcysteine radical. The derivative has good antitumor effect, can induce apoptosis of tumor cells, can directly kill Gram-positive bacteria (staphylococcus aureus) and drug resistance bacteria (MRSA5676 and MRSA5677), can inhibit the QS-system of Gram-negative bacteria (Pseudomonas aeruginosa), can inhibit and destroy the formation of biofilm of Pseudomonas aeruginosa; and exhibits significant hypoglycemic effect, so that it can be used in manufacture of medicaments for treatment of cancers, inflammation, diabetes, and bacterial and viral infections.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: February 5, 2013
    Assignee: Panorama Research Inc.
    Inventors: Yuqiang Wang, Xiaojian Jiang, Jie Jiang, Zaijun Zhang, Zhaoqi Yang, Pei Yu
  • Publication number: 20120276546
    Abstract: A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 1, 2012
    Applicant: Kao Corportation
    Inventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
  • Publication number: 20120226055
    Abstract: The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
    Type: Application
    Filed: February 24, 2012
    Publication date: September 6, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Himanshu Hemant Dhamankar, Collin Hunter Martin, Kristala Lanett Jones Prather
  • Publication number: 20120178927
    Abstract: The invention relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which J, X, Y, m and CKE are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the cycloalkylphenyl-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The invention furthermore relates to increasing the activity of crop protection compositions comprising compounds of the formula (I) by adding ammonium or phosphonium salts and, if appropriate, penetrants.
    Type: Application
    Filed: July 12, 2011
    Publication date: July 12, 2012
    Applicant: Bayer CropScience AG
    Inventors: Reiner FISCHER, Thomas BRETSCHNEIDER, Stefan LEHR, Dieter FEUCHT, Eva-Maria FRANKEN, Olga MALSAM, Alfred ANGERMANN, Guido BOJACK, Christian ARNOLD, Martin Jeffery HILLS, Heinz KEHNE, Christopher Hugh ROSINGER
  • Patent number: 8188145
    Abstract: Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. Initial studies have shown that patients can be taken off of morphine when the preferred alpha-methylene-gamma-butyrolactone is administered in a dosage of between 60 and 120 mg/day intramuscularly.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: May 29, 2012
    Assignee: Magnachem International Laboratories, Inc.
    Inventors: Federico M. Gomez, C. Federico Gomez Garcia-Godoy
  • Publication number: 20110213160
    Abstract: The invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I), in which CKE, W, X and Y are as defined above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides, and also to selective herbicidal compositions comprising firstly the 2,4,6-phenyl-substituted cyclic ketoenols and secondly at least one compound which improves crop plant tolerance.
    Type: Application
    Filed: April 15, 2011
    Publication date: September 1, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Thomas BRETSCHNEIDER, Reiner Fischer, Oliver Gaertzen, Klaus Kunz, Stefan Lehr, Dieter Feucht, Peter Lösel, Olga Malsam, Guido Bojack, Christian Arnold, Thomas Auler, Jeffrey Martin Hills, Heinz Kehne, Chris Rosinger
  • Patent number: 8008512
    Abstract: A pyridazine compound represented by formula (1): has an excellent plant disease controlling effect.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: August 30, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Morishita, Akio Manabe
  • Patent number: 7985771
    Abstract: The invention relates to a method of treating with furanone derivatives and the pharmaceutically acceptable salts thereof, one or more conditions of the skin, in particular regulating skin condition, regulating signs of skin aging, treating a number of conditions such as contact dermatitis, skin irritation, rosacea, acne, psoriasis, and preventing and protecting skin tissue against age-related damage or damage resulting from insults such as harmful (UV) radiation or environmental pollution, stress and fatigue.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: July 26, 2011
    Assignee: Monsanto Technology LLC
    Inventors: Sekhar Boddupalli, Gail Walkinshaw, Bing Wang
  • Publication number: 20110092368
    Abstract: The present invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I) in which W, X, Y and CKE have the meanings given in the disclosure, to a plurality of processes for their preparation and to their use as pesticides and/or herbicides. The invention further relates to selectively herbicidal compositions containing 2,4,6-phenyl-substituted cyclic ketoenols and a compound which improves crop plant tolerance.
    Type: Application
    Filed: December 17, 2010
    Publication date: April 21, 2011
    Inventors: Reiner Fischer, Klaus Kunz, Stefan Lehr, Michael Ruther, Udo Schneider, Markus Dollinger, Mark Wilhelm Drewes, Dieter Feucht, Jörg Konze, Ulrike Wachendorff-Neumann, Guido Bojack, Thomas Auler, Martin Jeffrey Hills, Thomas Bretschneider, Olga Malsam, Christoph Erdelen, Angelika Lubos-Erdelen, Alfred Angermann, Hein Kehne, Christopher Hugh Rosinger
  • Patent number: 7902383
    Abstract: A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting materials. A heterocyclic mercapto compound represented by Formula (1) (wherein X represents any structure of —O—, —S—, —NH—, and —NR1—; R1 represents any of an alkyl group, alkoxy group and alkoxyalkyl group each having 1 to 6 carbon atoms; Y represents an oxygen atom, a sulfur atom or —NR2—; R2 represents a hydrogen atom or alkyl group having 1 to 6 carbon atoms; and Z1 represents a divalent organic residue having at least one mercapto group) is produced by reacting a metal sulfide or a metal hydrosulfide with a compound represented by Formula (2) (wherein X and Y are as defined in Formula (1); and Z2 represents a divalent organic residue having at least one halogen group) in the presence of a solvent at a pH of 7.0 to 11.0.
    Type: Grant
    Filed: May 28, 2007
    Date of Patent: March 8, 2011
    Assignee: Showa Denko K.K.
    Inventors: Shinichi Yorozuya, Hidemasa Aoki
  • Patent number: 7834200
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 16, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Patent number: 7834196
    Abstract: A process for the production of N-alkylpyrrolidone from ?-butyrolactone and monoalkylamine in the liquid phase comprising the steps of: feeding monoalkylamine and ?-butyrolactone, in the absence of water or in the presence of less than about 1 wt % of water, to a reaction zone to form a reaction mixture; heating the reaction mixture; withdrawing a product stream from the reaction zone and passing the stream to a distillation zone comprising at least one distillation column operated at sub-atmospheric pressure; adding water to the distillation zone; isolating at least one overhead stream from the distillation zone comprising monoalkylamine, water and optionally N-alkyl-pyrrolidone and condensing the overhead stream against cooling water.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: November 16, 2010
    Assignee: Davy Process Technology Limited
    Inventors: John Richard Hensman, Riyaz Ezzuddin Khambati
  • Publication number: 20100184796
    Abstract: The present invention relates to agonists of the human bitter-taste receptors hTAS2R46, hTAS2R47 and hTAS2R50 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R46, hTAS2R47 and hTAS2R50 bitter taste transduction or bitter taste response.
    Type: Application
    Filed: March 31, 2008
    Publication date: July 22, 2010
    Applicant: DEUTSCHES INSTITUT FÜR ERNÄHRUNGSFORSCHUNG POTSDAM-REHBRÜCKE
    Inventors: Maik Behrens, Anne Brockhoff, Wolfgang Meyerhof, Giovanni Appendino, Valeria D' Auria
  • Patent number: 7759044
    Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
  • Publication number: 20100144866
    Abstract: Disclosed is a composition which is safe for a human body and an animal, can be ingested continuously on a daily basis, has an anti-fatigue activity, and is effective for the prevention or treatment of a disease or condition associated with fatigue. Specifically disclosed is an anti-fatigue agent comprising andrographolide optionally together with an ?-lipoic acid as an active ingredient(s). Also disclosed is a novel oral composition comprising andrographolide and an ?-lipoic acid. The anti-fatigue agent and the oral composition are useful for the prevention or treatment of chronic fatigue syndrome, overfatigue, physical fatigue, mental fatigue and organ fatigue.
    Type: Application
    Filed: May 30, 2008
    Publication date: June 10, 2010
    Applicant: Suntory Holdings Limited
    Inventors: Sumio Asami, Kayo Saito, Akifumi Maeda, Norifumi Tateishi
  • Publication number: 20100137618
    Abstract: Natural and synthetic compounds of Formulae Ia-Ie having a lactone structure, in particular Securolide, have been determined to be effective anti-tumor compounds which target the hrad9 gene and/or protein encoded thereby or complex containing the protein and/or the p53 gene and/or protein. Securolide is cytoselective for mutants of hRad9 based on studies conducted in Rad9 mutant yeast strains. Securolide appears to interact with mutant hRad9 in cancer cells to produce DNA lesions which result in apoptosis. Studies have demonstrated that Securolide is useful for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer, and to alleviate pain associated with the cancer.
    Type: Application
    Filed: October 26, 2009
    Publication date: June 3, 2010
    Inventors: Federico M. Gomez, C. Federico Gomez Garcia-Godoy, David Terrero
  • Publication number: 20100050719
    Abstract: The present invention concerns the field of bacterial biocontrol. More precisely, the invention relates to the identification of chemicals which promote the growth of bacteria inactivating NAHL, such as gamma-caprolactone (GCL) and 4-heptanolide (HTN) and their use in soil additives.
    Type: Application
    Filed: January 18, 2008
    Publication date: March 4, 2010
    Inventors: Denis Faure, Amélie Cirou, Yves Dessaux
  • Patent number: 7666904
    Abstract: The present invention provides a compound of formula I and the use thereof for the inhibition of bacterial cell wall biosynthesis and for the therapeutic treatment of bacterial infection or disease in a patient in need thereof. The present invention also provides the use of the formula I compound for the control of ecto- or endoparasites in homeothermic animals.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: February 23, 2010
    Assignee: Wyeth LLC
    Inventors: Craig Eugene Caufield, Schuyler Adam Antane, Koi Michele Morris, Shaughnessy McGrath Naughton, Dominick Anthony Quagliato, Patrick Michael Andrae, Annmarie Enos, John F. Chiarello
  • Publication number: 20090318715
    Abstract: The present invention relates to a process for preparing compounds of the formula (I) by reacting compounds of the formula (II) with thiolates (RS)nM. The present invention further relates to a process for preparing compounds of the formula (II) from ?-butyrolactone.
    Type: Application
    Filed: August 15, 2007
    Publication date: December 24, 2009
    Inventors: Patrick Deck, Kai Michael Exner, Boris Buschhaus
  • Publication number: 20090281301
    Abstract: The present invention relates to more improved process for preparing 2?-deoxy-2?,2?-difluoronucleoside and its intermediate. The present invention provide a process for preparing an erythro enantiomer in greater than 98% purity, comprising forming a lactone ring by hydrolyzing ethyl (3RS)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyloxolan-4-yl)propionate is hydrolyzed in the presence of hydrolysis reagents selected from acetic acid or chloroacetic acid, water and a mixture of organic solvents selected from the group comprising acetonilrile, dioxane, tetrahydrofuran or toluene, introducing a substituted benzoyl protecting group at the 3-position and 5-position, and recrys- tallizing said erythro enantiomer. Further, the present invention provides a process for selectively preparing, in greater than 99% purity, a beta-anomer 2?-deoxy-2?,2?-difluoronucleoside at the 3?-position and 5?-position that are protected by a substituted benzoyl in a 2:3 alpha/beta anomeric ratio.
    Type: Application
    Filed: December 11, 2006
    Publication date: November 12, 2009
    Applicant: DONG-A-PHARM.CO LTD
    Inventors: Moon-Sung Kim, Yong-Jik Kim, Jun-Ho Choi, Hong-Gyu Lim, Dae-Won Cha
  • Publication number: 20090247626
    Abstract: A method for treatment and or/prevention of dyslipidemia is provided. The invention relates to reducing low density lipoprotein cholesterol concentration by using naturally occurring diterpene (16?-hydroxycleroda-3,13(14)Z-dien-15,16-olide, a compound having formula (1)) isolated from leaves of Polyalthia longifolia.
    Type: Application
    Filed: November 25, 2008
    Publication date: October 1, 2009
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Koneni Vankata Sashidhara, Anju Puri, Jammikuntla Naga Rosaiah
  • Patent number: 7569518
    Abstract: A pyridazine compound represented by formula (1): has an excellent plant disease controlling effect.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: August 4, 2009
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Morishita, Akio Manabe